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8. Presence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study

Author

Stolnicu, Simona, Allison, Douglas, Tessier-Cloutier, Basile, Momeni-Boroujeni, Amir, Hoang, Lien, Ieni, Antonio, Felix, Ana, Terinte, Cristina, Pesci, Anna, Mateoiu, Claudia, Hodgson, Anjelica, Guerra, Esther, de Brot, Louise, Lastra, Ricardo R., Kiyokawa, Takako, Ali-Fehmi, Rouba, Kheil, Mira, Dundr, Pavel, Roma, Andres, Fadare, Oluwole, Turashvili, Gulisa, Oliva, Esther, Devins, Kyle M., Baiocchi, Glauco, Cibula, David, and Soslow, Robert A.

Published
2024
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12. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer – Update 2023

Author

Cibula, David, Rosaria Raspollini, Maria, Planchamp, François, Centeno, Carlos, Chargari, Cyrus, Felix, Ana, Fischerová, Daniela, Jahnn-Kuch, Daniela, Joly, Florence, Kohler, Christhardt, Lax, Sigurd, Lorusso, Domenica, Mahantshetty, Umesh, Mathevet, Patrice, Raj Naik, Mr, Nout, Remi A, Oaknin, Ana, Peccatori, Fedro, Persson, Jan, Querleu, Denis, Rubio Bernabé, Sandra, Schmid, Maximilian P., Stepanyan, Artem, Svintsitskyi, Valentyn, Tamussino, Karl, Zapardiel, Ignacio, and Lindegaard, Jacob Christian

Published
2023
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14. Clinical correlation of lymphovascular invasion and Silva pattern of invasion in early-stage endocervical adenocarcinoma: proposed binary Silva classification system

Author

Stolnicu, Simona, Hoang, Lien, Almadani, Noorah, De Brot, Louise, Baiocchi, Glauco, Bovolim, Graziele, Brito, Maria Jose, Karpathiou, Georgia, Ieni, Antonio, Guerra, Esther, Kiyokawa, Takako, Dundr, Pavel, Parra-Herran, Carlos, Lérias, Sofia, Felix, Ana, Roma, Andres, Pesci, Anna, Oliva, Esther, Park, Kay J., Soslow, Robert A., and Abu-Rustum, Nadeem R.

Published
2022
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17. Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis.

Author

Ven, Luna van de, Félix, Ana Clara, Suarez, Joana, Dias, Jorge, Pinto, Fátima F., and Laranjo, Sérgio

Subjects
RESISTANCE training, EXERCISE therapy, AEROBIC exercises, CARDIAC rehabilitation, AEROBIC capacity
Abstract

Background and Objectives: Despite advances in the surgical management of patients with Fontan circulation, their exercise capacity and quality of life remain significantly impaired. Exercise-based cardiac rehabilitation (CR) offers promising improvements in these areas, but the implementation and adherence to these programmes are often inconsistent. This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients. Materials and Methods: A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted on 24 August 2023. Studies were screened and assessed for quality using the Cochrane RoB Tool 2 and STROBE checklist. Meta-analysis was performed using a continuous random-effects model to determine the effectiveness of various CR interventions, including aerobic exercise training (AET), resistance training, and inspiratory muscle training (IMT). Results: A total of 26 studies (7 RCTs, 19 cohorts) comprising 22 distinct cohorts were included, with a total sample size of 428 Fontan patients. The interventions ranged from 4 weeks to 24 months and included AET (18 studies), resistance training (11 studies), and IMT (6 studies). The meta-analysis revealed significant improvements in exercise capacity, with a pooled mean difference in peak VO2 of 1.947 (95% CI: 1.491 to 2.402, p < 0.001). Subgroup analyses showed that combined AET and resistance training had the most robust effect, with a mean difference of 2.11 (95% CI: 1.57 to 2.65, p < 0.001). Home-based interventions showed significant benefits, while supervised and hybrid interventions did not show statistically significant differences. Publication bias was identified, particularly in home-based interventions, where smaller studies demonstrated larger effect sizes, as confirmed by Egger's test (Intercept = 2.417, 95% CI: 1.498 to 3.337, p = 0.001). However, no significant bias was detected in supervised or hybrid interventions, which displayed symmetrical distributions in funnel plots and non-significant Egger's test results. Conclusions: CR appears to be an effective intervention for improving exercise capacity in Fontan patients, particularly when combining AET with resistance training. Home-based programmes offer promising results, though the potential for publication bias, especially in smaller studies, warrants cautious interpretation of these findings. Further research is needed to refine protocols, explore long-term outcomes, and determine the underlying mechanisms, particularly for patients with more severe clinical presentations. The low incidence of adverse events across the studies reinforces the safety of these interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The Effect of Cardiac Rehabilitation in Paediatric Fontan Circulation Patients: A Prospective Intervention Study.

Author

Ven, Luna van de, Félix, Ana Clara, Suarez, Joana, Rodrigues, Bruno, Dias, Jorge, Pinto, Fátima F., and Laranjo, Sérgio

Subjects
AEROBIC capacity, QUALITY of life, EXERCISE therapy, AEROBIC exercises, CARDIAC surgery
Abstract

Background and Objectives: The Fontan procedure, a palliative surgery for univentricular heart physiology, often reduces exercise capacity and quality of life. This study aimed to evaluate the impact of cardiac rehabilitation (CR) on improving outcomes in Fontan patients to inform evidence-based care. Materials and Methods: Fontan patients aged 8–30 participated in a structured CR program for at least three months. The program included weekly aerobic and resistance training sessions with educational and nutritional guidance. Baseline and post-CR assessments included cardiac function, fitness, daily activity, and health-related quality of life (HRQOL). Results: The cohort included ten Fontan patients, of whom six had a right systemic ventricle. CR significantly improved cardiorespiratory fitness, as seen in VO2 max (from 27.92 ± 5.15 to 34.69 ± 1.14 mL/kg/min, p = 0.0089) and percent predicted VO2 (from 0.67 ± 0.18 to 0.90 ± 0.02, p = 0.005). VCO2 increased by +8.68 ± 8.59 mL/kg/min but did not reach statistical significance (p = 0.05). Most haemodynamic and ventilatory parameters showed no significant improvement. All the SF-36 questionnaire domains showed significant HRQOL gains (p < 0.001). High adherence (85–93%), no adverse events, and reduced NT-proBNP levels supported the program's safety. Conclusions: This study's findings have important implications for the care of Fontan patients. CR significantly improved exercise capacity and HRQOL in Fontan patients across various anatomies, particularly in the right systemic ventricle. Integrating physical conditioning into standard care could reduce long-term morbidity and mortality; however, further research is needed to refine the protocols and confirm sustained benefits. [ABSTRACT FROM AUTHOR]

Published
2024
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22. RISCO DE QUEDA NEONATAL NO TRANSPORTE INTRA-HOSPITALAR: PROPOSTAS DE INTERVENÇÕES COM BASE NO DIAGRAMA DE CAUSA-EFEITO

Author

Brito, Lívia Karoline Torres, primary, Cavalcante, Laysla de Oliveira, additional, Félix, Ana Letícia Martins, additional, Freitas, Lucas Lemos, additional, Rebouças, Nathália Patrício, additional, Moura, Larissa Brenda da Costa, additional, Soares, Noemi Andrelle, additional, Marinho, Larissa Régia da Fonsêca, additional, Silva, Roberta Luana da Conceição de Araújo, additional, Maciel, Nathanael de Souza, additional, Neto, Francisco Alves da Costa, additional, and Lopes, Emeline Moura, additional

Published
2022
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23. FORMANDO PESSOAS PARA UMA SOCIEDADE SUSTENTÁVEL

Author

Lima, Cristina Aparecida Barbosa de, primary, Almeida, Heloísa Santa Rosa de, additional, Costa, Leonardo Oliveira da, additional, Cruz, Vitória Sena, additional, Muniz, Iranice Gonçalves, additional, Teixeira, Vinícius de Souza, additional, Oliveira, Letícia Andrade Alves de, additional, Santos, Maria Gabriela Galdino dos, additional, Santos, Natinelle de Meneses Pinheiro, additional, Araújo, Albertina Maria Ribeiro Brito de, additional, Calisto, Júlia Kelly Pacheco, additional, Rangel, Izabela de Souza Lopes, additional, Barbosa, Rinaldo da Costa, additional, Melo, David Marx Antunes de, additional, Silva, Wedson Aleff Oliveira, additional, Rodrigues, Gabriel Torres, additional, Reis, Eduarda Fernandes dos, additional, Araújo, Alexandre Eduardo de, additional, Lemos, Augusto César Bezerra, additional, Bezerra, Ana Patrícia Almeida, additional, Pascoal, Leonardo Augusto Fonseca, additional, Filho, Alexandre Lemos de Barros Moreira, additional, Almeida, Gessica Caitano de, additional, Zafalan, Luisa Quarezemin, additional, Silva, Larissa Nicacio da, additional, Neto, Manoel Alexandre Diniz, additional, Diniz, Belísia Lúcia Moreira Toscano, additional, Mariano, Líllian Diniz, additional, Barreto, Paulo César Carneiro, additional, Santos, Teófilo de Medeiros, additional, Araújo, Sérgio Siddiney Borges de, additional, Silva, Diogo Fernandes da, additional, Figueiredo, Mateus Caldeira, additional, Barbosa, Lucas Brás, additional, Silva, Wedson Aleff Oliveira da, additional, Silva, Gerson João da, additional, Araujo, Alexandre Eduardo de, additional, Silva, Jurema Souza, additional, Araujo, Alexandre Eduardo, additional, Neto, José Lucivaldo Torquato, additional, Yogi, Euriko dos Santos, additional, Junior, Walfredo Ferreira de S., additional, Wanderley, Maria José Araújo, additional, Bandeira, Catarina de Medeiros, additional, Bandeira, Lucas Borchartt, additional, Félix, Ana Clara Almeida, additional, Santos, Djulian Leticia Lima dos, additional, Silva, Adelmo Ferreira, additional, Coaracy, Thiago do Nascimento, additional, Dantas, Aline Cavalcante, additional, Bezerra, Francisco Thiago Coelho, additional, Almeida, Jazielly Nascimento da Rocha, additional, Rangel, Izabela Sousa Lopes, additional, Cruz, George Rodrigo Beltrão da, additional, Santos, Maria das Graças dos, additional, Silva, Janaína Ribeiro da, additional, Alves, Marcus Vinicius de Fontes, additional, Nascimento, Silvânia Maria de Souza Gomes, additional, Libera, Rodrigo Della, additional, Araújo, Tiago Marques de, additional, and Macena, Djailson Januário, additional

Published
2022
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24. ESTUDO RETROSPECTIVO DA ANESTESIA INTRAVENOSA TOTAL (TRIPLE DRIP) DE EQUINOS EM CONDIÇÕES AMBULATORIAIS

Author

Ramos, Laís Caroline Gomes, primary, Freire, Claudio César dos Santos, additional, Félix, Ana Paula Menezes, additional, Oliveira, Aline dos Santos, additional, Feitosa, José Alan de Melo, additional, Lopes, José Witlley Castanha, additional, Souza, Ibenny Emanoel dos Santos, additional, Caldas Júnior, Neusvaldo de Medeiros, additional, and Calheiros, André Sampaio, additional

Published
2022
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28. Plagiocephaly and malocclusion

Author

Santos Félix, Ana Luiza, Stefani Soares, Sabrina, Ferreira Lima, Viviane, Santiago Júnior, Orlando, Santos Félix, Ana Luiza, Stefani Soares, Sabrina, Ferreira Lima, Viviane, and Santiago Júnior, Orlando

Abstract

The term plagiocephaly means oblique head. Most skull deformities are a result of intrapartum or utero molding but can be caused by congenital torticollis and after birth due to persistent head position of newborns staying in one head position for a long time and abusive use of strollers, car seats, car seats, swings. Its prevalence is growing fast, in 30 years it passes from 1 in each 300 babies in early nineties to 16 to 48 % in 2020. The aim of this paper is bringing the light to some serious conditions of treatment protocols in individuals with plagiocephaly. The skull deformity causes facial asymmetry that are not treatable by orthopedic or orthodontic intra or extra oral appliances, nor orthognathic surgery. Well, despite the fact that the patient or the tutors have to be notified of the facial asymmetry that persists, functional limitations will be presented. In more than 30 years of clinical experience treating these patients it was never sought the 4 first permanent molars and the 4 canines in the same Angle’s Class. In one side can be seen Class 1, but on the other it will be finding class 2 or class 3, the case reported exemplifies it, and the worst, mastication guidance will have to be very carefully done since, in most cases if it is tried to adjust the inferior and superior dental midline the vertical asymmetry of the occlusal plane (minimum vertical dimension) will worsen. Really there is no unique treatment protocol and it has to be considered case by case. It is time to deepen the knowledge in this area since the prevalence is growing. Based on the case reported, non-treated plagiocephaly can bring serious limitations to malocclusion treatment results. Further studies are necessary to a better understanding of the situation plagiocephaly versus malocclusion.

Published
2024

35. Plagiocephaly and malocclusion

Author

Santos Félix, Ana Luiza, primary, Stefani Soares, Sabrina, additional, Ferreira Lima, Viviane, additional, and Santiago Júnior, Orlando, additional

Published
2024
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36. Histopathological myocardial changes in patients with severe aortic stenosis referred for surgical valve replacement: a cardiac magnetic resonance correlation study

Author

Abecasis, João, primary, Lopes, Pedro, additional, Maltes, Sergio, additional, Santos, Rita Reis, additional, Ferreira, António, additional, Ribeiras, Regina, additional, Andrade, Maria João, additional, Uva, Miguel Sousa, additional, Gil, Victor, additional, Félix, Ana, additional, Ramos, Sancia, additional, and Cardim, Nuno, additional

Published
2024
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38. Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

Author

Ministerio de Ciencia e Innovación (España), European Commission, San-Félix, Ana [0000-0003-4271-7598], Peréz-Pérez, María-Jesús [0000-0003-1336-7760], Mingo-Casas, Patricia, Blázquez, Ana‑Belén, Gómez de Cedrón, Marta, San-Félix, Ana, Molina, Susana, Escribano‑Romero, Estela, Calvo‑Pinilla, Eva, Jiménez de Oya, Nereida, Ramírez de Molina, Ana, Saiz, Juan‑Carlos, Peréz-Pérez, María-Jesús, Martín Acebes, Miguel A., Ministerio de Ciencia e Innovación (España), European Commission, San-Félix, Ana [0000-0003-4271-7598], Peréz-Pérez, María-Jesús [0000-0003-1336-7760], Mingo-Casas, Patricia, Blázquez, Ana‑Belén, Gómez de Cedrón, Marta, San-Félix, Ana, Molina, Susana, Escribano‑Romero, Estela, Calvo‑Pinilla, Eva, Jiménez de Oya, Nereida, Ramírez de Molina, Ana, Saiz, Juan‑Carlos, Peréz-Pérez, María-Jesús, and Martín Acebes, Miguel A.

Abstract

Background Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeu‑ tic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infection with the mosquito‑borne flavivirus West Nile virus (WNV), a medically relevant neurotropic pathogen causing out‑ breaks of meningitis and encephalitis worldwide. Results A systematic literature search and meta‑analysis pointed to a misbalance of glucose homeostasis in the cen‑ tral nervous system of WNV patients. Real‑time bioenergetic analyses confirmed upregulation of aerobic glycolysis and a reduction of mitochondrial oxidative phosphorylation during viral replication in cultured cells. Transcriptom‑ ics analyses in neural tissues from experimentally infected mice unveiled a glycolytic shift including the upregula‑ tion of hexokinases 2 and 3 (Hk2 and Hk3) and pyruvate dehydrogenase kinase 4 (Pdk4). Treatment of infected mice with the Hk inhibitor, 2‑deoxy‑D‑glucose, or the Pdk4 inhibitor, dichloroacetate, alleviated WNV‑induced neuroinflammation. Conclusions These results highlight the importance of host energetic metabolism and specifically glycolysis in WNV infection in vivo. This study provides proof of concept for the druggability of the glycolytic pathway for the future development of therapies to combat WNV pathology.

Published
2023

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