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2. Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric surgery: Densidad mineral ósea y mecanismos de absorción de calcio dependientes de la expresión del receptor de la vitamina D en el intestino proximal después de la cirugía bariátrica

Author

Elias, E., Casselbrant, A., Werling, M., Abegg, K., Vincent, R. P., Alaghband-Zadeh, J., Olbers, T., le Roux, C. W., Fändriks, L, and Wallenius, V.

Published
2014

19. Abstracts of the Hans Selye Symposium on Neuroendocrinology and Stress: September 13–15, 1989 Estérel, Quebec, Canada

Author

Amjad, Hassan, Jafary, H. A., Bakke, H. K., Murison, R., Burks, T. F., Peterson, Julia M., Cho, C. H., Koq, M. W. L., Oqle, C. W., Evangelista, S., Renzi, D., Meli, A., Fändriks, L., Flemström, G., Garner, A., Gregory, H., Hampson, S. E., Stanier, A. M., Willshire, I. R., Young, J. A., Gilloteaux, J., Pomerants, B. J., Kelly, T. R., Menu, R., Pelletier, G., Vanderhaeghen, J. J., Glavin, G. B., Gompertz, R. H. K., Goodlad, R. A., Wright, N. A., Michalowski, A., Baron, J. H., Williamson, R. C. N., Mathie, R. T., Michalowskit, A., Guth, P., Hanson, W. R., Houseman, K. A., Collins, P. W., Henke, P. G., Hernandez, D. E., Walker, C. H., Xue, B. G., Fitts, N., Zhao, A. B., Valenzuela, J. E., Mason, G. A., Holzer, P., Japundžić, I., Levi, E., Rakić, L. J., Japundžić, M., Kauffman, Jr., G. L., Kitajima, M., Konturek, S. J., Krantis, A., McKay, A., Duchesne, L., Kuwayama, H., Matsuo, Y., Eastwood, G. L., Liu, Jun-Li, Zhang, Xi-Jin, Wang, Chih-Chun, Yao, De-Jia, Huang, Jin, Wei, Ning, MacOueen, G., Bienenstock, J., Perdue, M. H., Miller, T. A., Smith, G. S., Stanislawska, M., Phan, T. M., Henagan, J. M., Morales, R. E., Johnson, B., Szabo, S., Morris, G. P., Mózsik, Gy., Király, á., Garamszegi, M., Nagy, L., SütŐ, G., Tóth, Gy., Vincze, á., Jávor, T., Osumi, Y., Okuma, Y., Yokotani, K., Nagata, M., Paré, W. P., Redei, E., Rangachari, P. K., Prior, T., Bell, R. A., Shanahan, Fergus, Sikirić, P., Rotkvić, I., Miše, S., Petek, M., Ručman, R., Seiwerth, S., Marshall, J. F., Neumeyer, J. L., Taché, Y., Wallace, John L., Weiner, H., Xing, L., King, J., Bryan, R., Yabana, T., Kondo, Y., Yachi, A., Yagci, R. V., Alptekin, N., Rossowski, W. J., Brown, A., Coy, D. H., Ertan, A., Yeginsu, A. O., Hammer, R. A., Arimura, A., Zhang, W. -R., Robert, A., Zheng Z. T., Wang Z. Y., Zhang L., Huang C. W., Bertók, L., Vattay, P., Kato, K., Folkman, J., Pozo, F., Fueyo, A., Esteban, M. M., Marín, B., and Rojo-Ortega, J. M.

Published
1989
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20. Abstracts of the sixth international conference on experimental ulcer

Author

Aho, P., Lindén, I. -B., Nissinen, E., Pohto, P., Arvidsson, Stefan, Carter, Katharine, Silen, William, Avunduk, C., Polakouski, N. J., Quimby, G. F., Eastwood, G. L., Batzri, Shmuel, Bank, S., Greenberg, R. E., Kranz, V., Ilardl, C., Chemer, J. A., Singh, G., Naik, L., Chiverton, S. G., Hunt, R. H., Dammann, H. G., Kangah, R., Dreyer, M., Müller, P., Simon, B., Ezer, E., Fändriks, L., Jönson, C., Lisander, B., Frydman, G., O'Brien, P., Phelan, D., Flemström, G., Holmes, R., Malcontenti, C., Gompertz, R. H., Man, W. K., Li, S. K., Baron, J. H., Spencer, J., Michalowski, A. S., Gyires, Klara, Kovacs, Aniko, Gutknecht, John, Inauen, W., Rohner, C., Koelz, H. R., Herdmann, J., Schürer-Maly, C. C., Halter, F., Harmon, John, Hakki, Faris, Malthaner, Richard, Saini, Nirmal, Tay, Howard, Japundžić, L., Levi, E., Rakić, Lj., Holzer, P., Lippe, I. Tb., Pabst, H. A., Lorbach, M., Xing, L., Washington, J., Kauffman, G., Kawamura, Takeshi, Koizumi, Fumiaki, Ishimori, Akira, Kivilaakso, E., Kiviluoto, T., Mustonen, H., Konturek, S. J., Brzozowski, T., Dembinski, A., Uarzecha, Z., Konturek, J. W., Bielanski, W., Bogdał, J., Oleksy, J., Krämling, H. -J, Wiesinger, H., Merkle, T., Merkle, R., Enders, G., Drozdowicz, D., Garlicki, J., Kromer, W., Gönne, S., Lam SK, Chen BW, Hul WM, Ng MMT, Cho CH, Luk CT, Ligumsky, M., Sestieri, M., Karmeli, F., Rachmilewitz, D., Evangelista, S., Rovero, P., Mózsik, Gy., Fiegler, M., Garamszegi, M., Jáyor, T., Nagy, L., Sütő, G., Vincze, Á., Odes, HS, Hogan, DL, Ballesteros, MA, Wolosin, JD, Koss, MA, Isenberg, JI, Jávor, T., Vinoze, A., Steinbach, JH, Okabe, S., Kuwahara, Y., Nishida, T., Wang, J. Y., Nagai, H., Takeuchi, K., Palitzsch, K. D., Szabo, S., Pettersson, A., Peitsch, W., Lange, W., Parekh, D., Segal, I., Lawson, H. H., van der Walt, L. A., Sewing, K. -Fr., Beinborn, M., Seidler, U., Jansons, R., Silen, W., Spill, W. F., Pihan, G., Starlinger, H., Schiessel, R., Wenzl, E., Feil, W., Taché, Yvette, Keshavarzian, A., Wibowo, A., Fields, J. Z., Koji-Takeuchi, Nishiwaki, Hideyuki, Okabe, Susumu, Okada, Megumu, Niida, Hiromiti, Takeuchi, Koji, Vantrappen, G., Tarnawski, A., Hollander, D., Krause, W. J., Gergely, H., Yahav, J., Fradkin, A., Diver-Haber, A., Jonas, A., Allen, A., Leonard, A. J., and Pearson, J. P.

Published
1988
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21. Abstracts

Author

Abdullah, Lubna H., Buchanan, K. D., Akopyan, T. N., Arzumanyan, A. M., Arutunyan, A. A., Berger, H., Oehme, P., Atkinson, M. E., Chaggar, J. S., Bailey, S. J., Featherstone, R. L., Jordan, C. C., Morton, I. K. M., Balfe, A., Skrabanek, P., Powell, D., Barja, F., Mathison, R., Huggel, H., Bittiger, H., Heid, J., Björkroth, Ulla, Rosell, Sune, Boyd, N. D., Anthony, M. P., Leeman, S. E., Briggs, I., Growcott, J. W., Jamieson, A., Tarpey, Ann V., Brodin, E., Meyerson, B. A., Brown, J. R., Hayes, A. G., Meecham, K. G., Tyers, M. B., Burcher, E., Bynke, G., Håkanson, R., Hörig, J., Cann, John R., Rahim, Iffat, Vatter, Albert, Stewart, John M., Cascieri, Margaret A., Liang, Tehming, Cheeseman, H. J., Pinnock, R. O., Henderson, G., Constantinidis, J., Bouras, C., Taban, C. H., Guntern, R., Couture, R., Cuello, A. C., Dalsgaard, C. -J., Jonsson, C. -E., Arvidsson, J., Risling, M., Hökfelt, T., Schultzberg, M., Vincent, S. R., Elfvin, L. -G., de Beaurepaire, R., Iversen, S. D., Delbro, D., Lisander, B., Fändriks, L., Andersson, S. A., Del Fiacco, M., Dessi, M. L., Levarvti, M. C., Del Rio, J., Naranjo, J. R., Domschke, S., Bloom, S. R., Adrian, T. E., Lux, G., Bryant, M. G., McGregor, G. P., Domschke, W., Donnerer, J., Barthó, L., Holzer, P., Lembeck, F., Skofitsch, G., Elliott, P. J., Bannon, M. J., Alpert, J. E., Ferri, G. -L, McGregor, G., Vezzadini, P., Labo, G., Polak, J. M., Fontaine-Perus, J. C., Chanconie, M., Foreman, J. C., Piotrowski, W., Fox, J. E. T., Daniel, E. E., Jury, J., Domoto, T., Berezin, I., Gaudino, G., Mondardini, L., Fasolo, A., Gazelius, B., Kahan, T., Panopoulos, P., Olgart, L., Gintzler, Alan R., Jaffe, Bernard M., Baron, Sheri A., GrÖnstad, K. O., Ahlman, H., Zinner, M. J., Jaffe, B. M., Yeo, C., Gu, J., Huang, W. M., lslam, K. N., Terenghi, G., Morrison, J., Güllner, H. -G., Haeusler, Guenther, Handelmann, Gail E., Selsky, Joyce H., Helme, R. D., White, D. M., Höfler, H., Heitzt, Ph. U., Auböck, L., Petsche, Ulrike, Lippe, Irmgard, Hylden, Janice L. K., Wilcox, George L., Inoue, Atsuko, Nakata, Yoshihiro, Segawa, Tomio, Jakubowska-Naziemblo, B., Potargowicz, E., Traczyk, W. Z., Cannon, D., Rohde, W., JancsÓ, G., Király, E., Karcsú, S., Szebeni, A., Bácsy, E., Jones, R. S. G., Olpe, H. -R., Wrightt, D. M., Jurna, I., Kerdelhué, B., Lenoir, V., Pasqualini, C., El Abed, A., Morel, G., Dubois, P., Hublot, P., Tartar, A., Klingmúller, D., Waltz, C., Kramer, H. J., Koop, H., Luster, W., Gropp, C., Havemenn, K., Arnold, R., Krause, James E., McKelvy, Jeffrey F., Krivoy, W., Couch, J., Strand, F., Leander, S., Folkers, K., Lee, C. M., Snyder, S. H., Lindberg, P., Dahlström, A., Lundberg, J. M., Lindefors, N., Ungerstedt, U., Liu-Chen, L. -Y., Liszczak, T., Mayberg, M. R., Moskowitz, M. A., Lundberg, Jan M., Saria, Alois, Brodin, Ernst, Martling, Claes-Roland, Hökfelt, Tomas, Lundblad, Lars, Änggård, Anders, McGeeney, K. F., O'Donnell, M. D., Blank, M. A., Manolas, K., Linger, W. G., Allen, J. M., Maggio, J. E., Sandberg, B. E. B., Bradley, C. V., Iversen, L. L., Santikarn, S., Williams, D. H., Hunter, J. C., Hanley, M. R., Magnusson, I., Thulin, L., Mandahl, Agneta, Bill, Anders, Manning, Maurice, Martensson, H., Akande, B., Stofer, P., Chappuis, G., Immer, H., Groog, P., Matthews, Margaret R., Connaughton, M., Moratalla, R., Nobin, Anders, Emson, Piers, Sundler, Frank, O'Donohue, T. L., Shults, C. W., Quirion, R., Moody, T. W., Chase, T. N., Otsuka, M., Konishi, S., Yanagisawa, M., Akagi, H., Otten, U., Rüegg, U. T., Pawlik, W., Konturek, S. J., Kania, J., Gustaw, P., Cosgrove, Patricia G., Pazoles, Christopher J., Priestley, J. V., Jensen, R. T., Pert, C. B., Regoli, D., Mizrahi, J., D'Orléans-Juste, P., Caranikas, S., Escher, E., Folkers, Karl, Rüegg, Urs T., Bishai, W. R., Saria, A., Rama Sastry, B. V., Jaiswal, Neelam, Tayeb, Osama S., Schultheiss, Hartmut, Hörig, Joachim, Scott, T. M., Shanahan, F., Befus, A. D., Fox, J., Denburg, J. A., Bienenstock, J., Sheppard, M. N., Kurian, S. S., Siegel, R. A., Weidenfeld, J., Globus, M., Melamed, E., Sjödin, L., Srivastava, G., Hall, Michael E., Suhar, A., Turk, V., Marks, N., Szkudlarek, U., Tarkkanen, A., Tervo, T., Tervo, K., Eränkö, L., Eränkö, O., Huang, W. -M., Morrison, J. F. B., Unger, W. G., Tessler, A., Himes, B. T., Murray, M., Goldberger, M. E., Torrens, Y., Beaujouan, J. C., Viger, A., Glowinski, J., Casanueva, F. F., Knuth, E., Havlicek, V., Friesen, H. G., Triepel, J., Weindl, A., Reinecke, M., Mader, J., Forssmann, W. G., Unger, Thomas, Becker, Hans, König, Manfred, Ganten, Detlev, Lang, Rudolf E., Vacca, L. L., Naftchi, N. E., Guan, X. -M., Ai, M. -K., Vijayan, E., Wang, Y. M., Mashford, M. L., Watson, Stephen P., Sandberg, Bengt E. B., Iversen, Leslie L., Weihe, E., Hartschuh, W., Kuchling, G., Winter, E. A., Keen, P., Yeo, C. J., Ylikoski, Jukka, Tervo, Timo, Tervo, Kaarina, Eränko, Liisa, and Cuello, Claudio

Published
1983
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24. Roles of the gut in the metabolic syndrome: an overview.

Author

Fändriks, L.

Subjects
*METABOLIC syndrome, *OBESITY, *DIABETES, *CARDIOVASCULAR diseases, *MORTALITY
Abstract

The metabolic syndrome is a cluster of risk factors (central obesity, hyperglycaemia, dyslipidaemia and arterial hypertension), indicating an increased risk of diabetes, cardiovascular disease and premature mortality. The gastrointestinal tract is seldom discussed as an organ system of principal importance for metabolic diseases. The present overview connects various metabolic research lines into an integrative physiological context in which the gastrointestinal tract is included. Strong evidence for the involvement of the gut in the metabolic syndrome derives from the powerful effects of weight-reducing (bariatric) gastrointestinal surgery. In fact, gastrointestinal surgery is now recommended as a standard treatment option for type 2 diabetes in obesity. Several gut-related mechanisms that potentially contribute to the metabolic syndrome will be presented. Obesity can be caused by hampered release of satiety-signalling gut hormones, reduced meal-associated energy expenditure and microbiota-assisted harvest of energy from nondigestible food ingredients. Adiposity per se is a well-established risk factor for hyperglycaemia. In addition, a leaky gut mucosa can trigger systemic inflammation mediating peripheral insulin resistance that together with a blunted incretin response aggravates the hyperglycaemic state. The intestinal microbiota is strongly associated with obesity and the related metabolic disease states, although the mechanisms involved remain unclear. Enterorenal signalling has been suggested to be involved in the pathophysiology of hypertension and postprandial triglyceride-rich chylomicrons; in addition, intestinal cholesterol metabolism probably contributes to atherosclerosis. It is likely that in the future, the metabolic syndrome will be treated according to novel pharmacological principles interfering with gastrointestinal functionality. [ABSTRACT FROM AUTHOR]

Published
2017
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45. Surgery in the treatment of type 2 diabetes mellitus

Author

Victorzon, Mikael, Salminen, Paulina, Maleckas, A., Venclauskas, L., Wallenius, V., Lönroth, H., and Fändriks, L.

Abstract

Background and Aims: The prevalence of diabetes is increasing worldwide, and most of the cases are type 2 diabetes mellitus. The relationship between type 2 diabetes mellitus and obesity is well established, and surgical treatment is widely used for obese patients with type 2 diabetes mellitus. The aim was to present current knowledge about the possible mechanisms responsible for glucose control after surgical procedures and to review the surgical treatment results.Material and Methods: Medical literature was searched for the articles presenting the impact of surgical treatment on glycemic control, long-term results, and possible mechanisms of action among obese individuals with type 2 diabetes mellitus.Results: Remission of type 2 diabetes mellitus after bariatric surgery depends on the definition of the remission used. Complete remission rate after surgery with the new criteria is lower than was considered before. Randomized controlled studies demonstrate that surgery is superior to best medical treatment for the patients with type 2 diabetes mellitus. The recurrence of type 2 diabetes mellitus after bariatric surgery is observed in up to 40% of cases with =5?years of follow-up. Despite the recurrence of type 2 diabetes mellitus in this group, better glycemic control and lower risk of macrovascular complications are present. Incretin effects on glycemic control after bariatric surgery are well described, but the role of other possible mechanisms (bile acids, microbiota, intestinal gluconeogenesis) in humans is unclear.Conclusion: Surgery is an effective treatment of type 2 diabetes mellitus in obese patients. The most optimal surgical procedure for the treatment of obese patients with type 2 diabetes mellitus is still to be established. More research is needed to explore the mechanisms of glycemic control after bariatric surgery.

Published
2015
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