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O Planejamento Estratégico do Tribunal de Justiça de Pernambuco (TJPE), desde 2016, reafirma a urgência da Agenda 2030 da Organização das Nações Unidas (ONU), relacionada aos Objetivos do Desenvolvimento Sustentável (ODS). Nessa perspectiva, em 2017, o TJPE firmou contratos voltados à coleta seletiva junto ao Fórum Desembargador Rodolfo Aureliano (FDRA). O objetivo do trabalho foi traçar o escopo do TJPE para a sustentabilidade decorrente do contrato com a Cooperativa de Trabalho de Catadores de Resíduos Sólidos Recicláveis (COOPAGRES) nos anos de 2019 a 2021. O método teve abordagem quali-quantitativa, descritiva pesquisa de natureza exploratória, classificada como aplicada e documental de estudo de caso. Os dados de Resíduos Sólidos Recicláveis (RSR) são provenientes do Planejamento Logístico Sustentável (PLS) e de visitas à COOPAGRES e FDRA. Foi detectado aumento na arrecadação e destinação correta de RSR no PLS/2019; em 2020, as metas foram reajustadas devido à pandemia de COVID 19; em 2021, o resultado foi superior à meta, devido ao retorno ao trabalho presencial. Na arrecadação convencional do FDRA no RSR analisado, em 2019, o papel prevalece em 45%, os demais RSR representam 29%, enquanto o recolhimento ocasional teve média de 26%. Em março/2022, a participação chegou a 59%. Em relação ao índice FDRA per capita, em 2019, foi de 155,55 kg/hab/ano: em 2020, 14,71 kg/habitante/ano e em 2021, 20,33 kg/habitante/ano. No período, o FDRA obteve um aperfeiçoamento, mas o planejamento na gestão da RSR precisa difundir uma postura que vise o entrelaçamento das dimensões da sustentabilidade compatíveis com os elementos do desenvolvimento sustentável, mandamento civilizatório global.

La conciencia tributaria se refiere a motivaciones intrínsecas de las personas a pagar voluntariamente los impuestos y a las actitudes, creencias y percepciones de las personas, es decir los aspectos no coercitivos, que motivan la disposición a cooperar con el sistema tributario de un país (Bravo, 2011). La universidad se considera un espacio privilegiado para la educación tributaria, por lo que la intervención para formar la conciencia tributaria debería involucrar a los estudiantes universitarios (Blasco, 2018). En ese sentido, la Administración Tributaria del Perú en convenio con la Universidad ha replicado un modelo internacional de intervención denominado “Programa NAF” para formar conciencia tributaria en los estudiantes que tendrá efecto replicador en la ciudadanía. El objetivo de la presente investigación fue determinar la influencia del “Programa NAF” en la formación de conciencia tributaria en estudiantes universitarios. Fue de enfoque cuantitativo, tipo aplicada, diseño pre-experimental teniendo como muestra a 22 estudiantes de la facultad de contabilidad de una universidad peruana. Para esta investigación se ha empleado un instrumento confiable y debidamente validado que mide el nivel de conciencia tributaria. En los resultados se determinó que la implementación del Programa NAF influye positiva y significativamente en la formación de conciencia tributaria de los estudiantes, obteniéndose entre los datos del pre test y post test, un incremento de la mediana de datos de moderada a alta, una T de Wilcoxon = 0 que es menor a 65 (valor crítico) y un nivel de significancia de p = 0.000 que es menor a 0.05.

Este articulo tiene como objetivo resaltar las contribuciones del proyecto “Impactos de las nanotecnologias en la salud de los trabajadores” desarrollado por Fundacentro, Brasil, entre 2006 y 2019, para la formacion de trabajadores con miras a la gobernanza participativa en nanotecnologia. Como indicadores de estos aportes se utilizo la descripcion de las acciones desarrolladas y una coleccion de citas encontradas en Internet sobre el proyecto, especialmente las producidas por sindicatos u organizaciones de trabajadores. De esta forma, destacando las acciones llevadas a cabo y las referencias que se hacen sobre estas acciones en Internet y las publicaciones sobre el tema, es posible no solo garantizar la relevancia del proyecto, sino tambien obtener una indicacion coherente del alcance y difusion de los conocimientos abordados.

SummaryThe Rio Branco is a river with unique biogeographic and ecological features, threatened by the Brazilian Government’s plan to build a major hydroelectric dam and associated hydroway along its course. The river crosses one of Amazonia’s largest rainfall gradients and a major geomorphological boundary along a savanna/forest ecotone, marked by the Bem Querer rapids. Above the rapids, the upper Rio Branco runs through the Boa Vista sedimentary formation and crosses the crystalline rocks of the Guiana Shield, and its margins are flanked by gallery forests. Downriver, it runs through a low-lying sedimentary basin, with Amazonian floodplain forests along its margins. Here, we present the results of ∼ 15 years of ornithological research on the Branco and its major tributaries, providing baseline data and evaluating potential threats to the riverine avifauna. Our surveys included opportunistic observations and standardized surveys along the entire length of the river in 16 systematically distributed localities. We catalogued 439 bird species, 87% of which are documented by physical evidence (specimens, recordings, photographs). Forty-six percent are restricted to single habitats, suggesting a high degree of habitat specialisation. A third of the species are widely distributed along the river, whereas 45% are restricted to either the upper or the lower Rio Branco, including 40 and 30 Indicator Species, respectively. Twenty-five species are threatened at global or national levels, including two ‘Critically Endangered’, nine ‘Vulnerable’, and 14 ‘Near Threatened’. We present a list of 50 bird species that are candidates for monitoring studies. Threats to the avifauna from dam construction include permanent flooding above the dam, eliminating gallery forests, river islands, and sandy beaches, and the disruption of the flood pulse along the river, affecting river island and floodplain forest specialists, many of which are globally threatened with extinction. If built, the Bem Querer dam will wipe out the ecotone region and affect dramatically the river’s avifauna.

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico Os projetos arquitetônicos dos galpões de triagem de materiais recicláveis são orientados por documentos e manuais técnicos que têm-se mostrado insuficientes para a concepção de espaços funcionais e habitáveis. A inadequação dos projetos é um dos fatores que explica a precariedade e a baixa produtividade dos galpões de triagem de materiais recicláveis. Este trabalho contribui para a elaboração de diretrizes espaciais e organizacionais para orientar os processos de concepção e as reformas de galpões, atendendo a uma demanda frequente das associações de triadores: melhorar suas condições de trabalho e aumentar a produtividade. Dentro da cadeia produtiva da reciclagem, a triagem é ao mesmo tempo a etapa que mais agrega valor aos materiais e o principal gargalo. O foco deste trabalho é a triagem em bancada de silo em uma cooperativa de Belo Horizonte. Através da análise ergonômica do trabalho, buscou-se uma compreensão mais detalhada sobre a complexidade da atividade de triagem, que vem sendo reduzida nos manuais tradicionais. Baseando-se em conceitos de Christopher Alexander, este trabalho propõe uma linguagem de padrões como um guia prático de construção. A linguagem de padrões serve como instrumento de comunicação entre o técnico e os usuários, permitindo que eles participem não apenas como informantes, mas também como agentes que decidem sobre o projeto. A base do método é estabelecer diretrizes técnicas com recomendações gerais sobre a configuração do projeto, cujos detalhes devem ser definidos em cada contexto. Este trabalho desenvolve padrões para a atividade de triagem em bancada na forma de fichas técnicas que trazem considerações dos fatores que incidirão na configuração espacial dos postos de trabalho e que devem ser levados em conta na concepção do projeto arquitetônico. The design of shed projects for the separation of recyclable materials is guided by several manuals and official documents that are considered insufficient for conceiving habitable and functional spaces. This aspect, among others, explains the precarious conditions and the low productivity of these sheds. The objective of this work is to contribute to the elaboration of directives both spatial and organizational to help the process of designing and reforming sheds and to answer to a demand of affected workers: improve their work conditions and increase their productivity. Within the recycling chain, the separation of materials is at the same time the one that adds most value to collected materials and the main bottleneck. The focus of this work is a case study of bench separation in an association of workers in Belo Horizonte, Brazil. The ergonomic analysis of labor in this case revealed the complexity of the separation activity, which has been oversimplified in current guiding manuals. Based upon the concepts and methodologies of Christopher Alexander, this work aims at proposing a language of patterns as a practical guide for construction. This language provides a communication tool that promotes the interaction between architect and users, allowing them to contribute and participate in the decisions about the project. The essence of the method is to establish broad technical directives with general recommendations about the project and leave the details to be defined according to each concrete context. This work develops several patterns for the bench separation of materials and presents those directives in the form of a technical file in which are discussed factors that influence the separation activity and thus must be taken into account by designers.

One of the major genetic insights into the pathogenesis of polycythaemia vera included the identification of the somatic point gain-of-function mutations in Janus kinase 2 gene—first JAK2V617F on exon 14, present in 95%–97% of the cases, and later on exon 12. In the literature, we can find some reported studies where different exon 12 mutations are identified. Unlike patients with JAK2V617F mutation in exon 14, the mutation at exon 12 is not usually associated with an increase in the three haematopoietic series (erythrocytosis, leucocytosis and thrombocytosis). It appears to be associated with a distinct syndrome, mostly characterised by isolated and more marked erythrocytosis, independently of the mutational variant. We report here the case of a patient who is JAK2exon 12 positive, presenting a novel mutation—c.1605G>T (p.Met535Ile)—associated with c.1612C>T (p.His538Tyr) mutation previously described, evidencing an atypical clinical phenotype.

High resolution genome-wide copy number analysis, routinely used in clinical diagnosis for several years, retrieves new and extremely rare copy number variations (CNVs) that provide novel candidate genes contributing to disease etiology. The aim of this work was to identify novel genetic causes of neurodevelopmental disease, inferred from CNVs detected by array comparative hybridization (aCGH), in a cohort of 325 Portuguese patients with intellectual disability (ID)., This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the projects: PIC/IC/83026/2007, PIC/IC/83013/2007 and POCI-01-0145-FEDER-007038. This work has also been funded by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). FL was supported by Foundation for Science and Technology (FCT) through the fellowship SFRH/BD/90167/2012.

Copy number variations (CNVs) at the 7q33 cytoband are very rarely described in the literature, and almost all of the cases comprise large deletions affecting more than just the q33 segment. We report seven patients (two families with two siblings and their affected mother and one unrelated patient) with neurodevelopmental delay associated with CNVs in 7q33 alone. All the patients presented mild to moderate intellectual disability (ID), dysmorphic features, and a behavioral phenotype characterized by aggressiveness and disinhibition. One family presents a small duplication in cis affecting CALD1 and AGBL3 genes, while the other four patients carry two larger deletions encompassing EXOC4, CALD1, AGBL3, and CNOT4. This work helps to refine the phenotype and narrow the minimal critical region involved in 7q33 CNVs. Comparison with similar cases and functional studies should help us clarify the relevance of the deleted genes for ID and behavioral alterations., FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the projects PIC/IC/83026/2007, PIC/IC/83013/2007, and POCI-01-0145-FEDER-007038. This work has also been funded by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), info:eu-repo/semantics/publishedVersion

The project which is presented in the following article aims to the inclusion of the information and communication technology (ICT) in the field of Primary Education, within the area of Physical Education. There is no doubt that we are currently immersed in a digital revolution which affects different contexts, including formal education. In the field of Primary Education, the inclusion of the information and communication technologies is necessary in order to use the technological resources in the school curriculum. There is evidence that teacher do not possess enough digital competence to develop ICT related activities. The present article aims to analyze the introduction of these technologies in a specific context: the Physical Education area. We aimed to assess the knowledge, training and the utility of ICT by teachers, to be able to work with them in the classroom. The general aim is to consolidate the use of technologies of the information as a great teaching tool in the context of Physical Education.

While many published maps of avian species richness indicate northern Amazonia to be somewhat species-poor, recent surveys reveal that this area actually possesses one of the most species-rich avifaunas in the Neotropical lowlands. Our surveys indicate that at least 520 bird species occur in Virua National Park (VNP) and adjacent areas, which is located in the Brazilian state of Roraima (northern Amazonia). Here, we present the results of our ornithological efforts since 2001, based on audio-visual and mist-netting surveys, vouchered by tape and digital recordings, photographs, and collected specimens. VNP is dominated by Amazonian white-sand forest (locally known as campina and campinarana) on an extensive foodplain influenced by muddy-, clear-, and black-water rivers, forming a complex mosaic of habitats that includes varzea, igapo, and hilltop “islands” with terra-firme forest. Te high avian diversity found at VNP is likely due to both biogeographic- and local-scale processes. Each habitat contains a particular avian assemblage. Patches of terra-firme forest have a typical Guianan avifauna. Campina and campinarana contain unique species, including some poorly known and range-restricted (e.g., Aprositornis disjuncta), as well as species typical of the northern Roraiman savannas (e.g., Icterus nigrogularis). Te varzea of the Rio Branco (with its associated river islands) is particularly species-rich, including the endemic Cercomacra carbonaria and isolated populations of white-river-island specialists (e.g., Mazaria propinqua). VNP protects important ecological ecotones and biogeographical contact zones, as well as 27 threatened and 45 migratory bird species. On the other hand, 71 species reported for our study area have been found outside the current boundaries of the park. Ongoing proposals of expanding the limits of the park would absorb most of these species. With its outstanding bird species richness and wide variety of habitats, VNP emerges as an important site for Amazonian avian research, tourism, and conservation. Despite the park’s protected status, the Brazilian government plans to build a hydroelectric dam in the region, representing the main threat to its avifauna and overall biodiversity.

A formação em Arquitetura e Urbanismo com sua característica generalista envolve, em sua natureza, conhecimentos de diversas áreas (tecnologia, teoria, história, representação, projetação), sendo o espaço da concepção projetual o local onde a síntese destes conhecimentos se reflete de forma mais clara. Acreditamos que o trabalho integrado nos currículos de arquitetura pode proporcionar uma visão global do projeto, contribuindo assim para uma melhor formação do arquiteto. O presente trabalho se propõe a refletir sobre o papel da integração e a interdisciplinaridade no ensino de projeto de arquitetura. Este tema vem sendo trabalhado de forma recorrente por críticos na área de ensino de projeto e nos eventos da área como os seminários do Projetar, sendo destacada por vários autores a busca da integração como uma postura pedagógica essencial ao ensino de projeto. O trabalho pretende contribuir para uma reflexão e conscientização dos envolvidos na importância da integração nos processos de projetos do curso de arquitetura. Para isto analisamos as potencialidades e limites deste processo no Curso de Arquitetura e Urbanismo (CAU) da Universidade Potiguar (UnP) de Mossoró, que possui a integração e interdisciplinaridade registrada desde o Projeto Pedagógico do Curso. Esta análise será realizada através da observação do desenvolvimento do “trabalho interdisciplinar” da quinta série durante o semestre de 2014.1. A pesquisa diz respeito a um estudo exploratório de natureza qualitativa que pretende investigar temas específicos sobre o ensino/aprendizagem de projeto de arquitetura e sobre a integração nos cursos de arquitetura, seguindo de uma observação não participativa nas aulas de projeto de arquitetura na quinta série do CAU/UnP/Mossoró e análise dos produtos finais, que seriam os trabalhos da última unidade do semestre, chamados de “trabalhos Interdisciplinares”. Foram também aplicados, via e-mail, e analisados, questionários com os professores que participaram do processo. A reflexão corrobora diversas outras já realizadas no sentido de identificar as dificuldades inerentes à aplicação destes princípios de forma satisfatória. Ressalta-se, contudo, que a interdisciplinaridade, de fato, vai muito além da integração e é ainda mais difícil de ser alcançada. Além de um projeto pedagógico que incorpore estes princípios, como é o caso do Curso de Arquitetura e Urbanismo da UNP-Mossoró, faz-se necessário a adesão completa por parte do corpo docente e discente desta filosofia de ensino. Training in Architecture and Urbanism with its general characteristic involves, in its nature, knowledge of various areas (technology, theory, history, representation, and design), being the space of design conception that place where the synthesis of this knowledge is reflected more clearly. We believe that the integrated work in the architectural curriculum can provide an overview of the project, thus contributing to better training of the architect. This research aims to reflect on the role of integration and interdisciplinary in teaching architectural design. This theme has been work recurrently by critics in the teaching area of project and events of the area as the seminars of the Projetar, highlighted by several authors to search integration as an essential pedagogical approach to design education. The work aims to contribute to reflection and awareness of those involved on the importance of integration in the architectural course of project processes. For this, we analyzed the potential and limits of this process in Architecture and Urbanism Course (CAU) at the Universidade Potiguar (UNP) Mossoró, which has the integration and interdisciplinary recorded since the Pedagogical Project of the Course. This analysis will be performed by observing the development of “interdisciplinary work” in the fifth term during the first half of 2014.1. This research concerns an exploratory qualitative study that aims to investigate specific issues on the teaching/learning architecture project and the integration in architecture courses, following a non-participant observation in architectural design classes in the fifth term of CAU/UnP/ Mossoró, and analysis of final products, which would be the work of the last unit of the semester, called “Interdisciplinary work”. Questionnaires for the teachers who participated in the process has been apply via email and analyzed. Reflection supports several other already carried out to identify the difficulties inherent in applying these principles satisfactorily. Noting, however, that interdisciplinarity, in fact, it goes beyond integration and is even more difficult to achieve. In addition to an educational project that incorporates these principles, such as the course of Architecture and Urbanism of the UNP-Mossoró, full adhesion it is necessary by the faculty and students of this teaching philosophy.

Desde 1965 em que se colocaram as primeiras próteses osteointegradas sob os princípios de Brånemark, a implantologia sofreu uma constante e notória evolução e consiste, hoje, na primeira linha de tratamento em reabilitação oral. Os mecanismos que induzem a adesão óssea ou a união entre o implante e o osso, ainda não são perfeitamente conhecidos. As conclusões que se obtiveram das pesquisas, demostraram que a taxa de osteointegração dos impantes e o índice de sucesso relacionam-se com a composição química e com a rugosidade da superfície. Os implantes com rugosidades superficiais possuem maior estabilidade primária e modificam os mecanismos de interação das células com a superfície, quando comparados com os de superfície lisa. Quanto à composição química das superfícies dos implantes, as enriquecidas com cálcio e hidroxiapatite, favorecem e promovem o processo de cicatrização e de deposição óssea. Os estudos comparativos entre as superfícies modificadas por métodos de tratamento físicos e/ou químicos, quando comparados com as superfícies maquinadas, demonstram a superioridade das superfícies rugosas em muitos aspectos biomecânicos, sendo hoje um consenso entre a comunidade científica, a superioridade das superfícies modificadas. Independentemente das evidências científicas apontarem para maiores taxas de sucesso associadas ás superfícies tratadas, ainda há um longo caminho a percorrer para colmatar todas as falhas existentes na atualidade. O objetivo deste trabalho foi a realização de uma revisão bibliográfica, através da pesquisa de artigos da Pubmed, B-On, Science Direct, Scielo de forma a aprofundar conhecimentos das vantagens e desvantagens da rugosidade presente na superfície implantar, assim como alertar os médicos dentistas para a importância a ter com a rugosidade em excesso e tentar perceber qual a rugosidade dita ideal. Não se limitou o tempo de pesquisa mas deu-se relevância a referências científicas dos últimos 20 anos, publicados em língua portuguesa e inglesa. Since 1965, when the first osseointegrated prosthesis under the principle of Brånemark implantology has suffered a constant and notorious evolution and nowadays is the first option in treatments of oral rehabilitation. Implants with surface roughness have more stability and modify the mechanism between the cells and the surface, when compared with a plain surface. Talking about the chemical composition of the surface of the implants, the ones that have calcium and hydroxyapatite enhance the process of scarring and bone deposition. Comparatives studies show that modified surface with physical and/or chemical treatments are better than machined surface. Regardless of the scientific evidence showing that there is a more success rate on treated surfaces, there is still plenty to achieve. The purpose of this essay was to do a research based on Pubmed, B-On, Science Direct articles in order to expand the advantages and disadvantages of roughness surfaces, thus, to alert medical dentists of the importance of having an exaggerated roughness. This search was specified for the scientific references of the last 20 years that were published in Portuguese or English.

Given the importance of green lacewings as agents of biological pest control, the present study aimed to evaluate the toxicity of insecticides used on coffee crops on the eggs and larvae of Chrysoperla externa . The insecticides tested were (g or mL a.i./L) chlorpyrifos (2.25), cartap hydrochloride (1.66), pyriproxyfen (0.33), profenofos/lufenuron (1.33/0.13), fenpropathrin (0.40), triazophos/deltamethrin (0.70/0.02) and zetacypermethrin (0.05). The insecticides, when applied directly on the eggs, caused no adverse effects on the duration of the embryonic period. After the application of triazophos/deltamethrin, pyriproxyfen, profenofos/lufenuron and zetacypermethrin, a reduction in egg viability was induced. The insecticides triazophos/ deltamethrin, chlorpyrifos, and profenofos/lufenuron reduced the survival of newly hatched first instar larvae from treated eggs. The first instar larvae that were treated directly were sensitive to the effects of the products used, with the effect of triazophos and chlorpyrifos/deltamethrin being high. The survival of the second instar larvae was reduced by zetacypermethrin, fenpropathrin, profenofos/lufenuron, and cartap hydrochloride. The products chlorpyrifos and triazophos/deltamethrin also did not allow second instar larvae survival. For treated third instar larvae, chlorpyrifos and triazophos/deltamethrin allowed survival of only 20.0 and 57.5%. Eggs and larvae of C. externa showed sensitiveness to insecticides chlorpyrifos and triazophos, being needed more studies in semi-field and field conditions for the confirmation or not of the toxicity aiming the conservation of this predator specie on the coffee agroecosystem.

O trabalho foca alguns aspectos relativos à usabilidade e acessibilidade de caixas bancários de auto-atendimento (CAA), aspectos esses que ficam evidenciados como sendo problemas quando os usuários são pessoas idosas e, como tais, podem ter implicações sobre a saúde e os estados de saúde dos mesmos. A pesquisa foi conduzida tendo como objeto de análise os CAA instalados em agências de dois bancos estatais, tendo sido a interação dos usuários avaliada utilizando-se metodologia de análise quantitativa, através de uma amostra constituída por 70 clientes idosos. A pesquisa de campo demonstrou que, nas situações de interação com os CAA, prevalecem os estados de intranqüilidade entre os usuários idosos, e que esses usuários estão expostos a uma grande carga psíquica. O estudo discrimina tanto algumas das características negativas que foram observadas nesses ambientes, bem como adverte porque essas características são desfavoráveis para as pessoas idosas. Além disso, assinala para a necessidade de aperfeiçoamentos nesses serviços, bem como para o desenvolvimento de pesquisas que avaliem o impacto dessa carga psíquica sobre a saúde das pessoas idosas.This study focuses on some aspects related to the usability and accessibility of automated teller machines (ATM), identified as problematic for elderly users. Some of these problems can interfere with the health and the health status of these users. This study was carried out in two ATMs installed in agencies of two public bank institutions. The interaction of the users with the ATMs was evaluated by quantitative analysis, using a sample of 70 aged customers. The results demonstrated that the elderly felt uneasy using the ATMs, suffering great psychic pressure. This study not only rejects some of the negative characteristics observed in these environments but also alerts to their unfavorable impacts upon the health of the elderly. Moreover, it points to the need for improving these services and for investigations evaluating the impact of the psychic pressure upon the health of elderly people.

Flooded forests represent an important part of Amazonian diversity, yet the distribution, ecology, and evolutionary history of the avifauna of these forests have received little attention. We conducted ornithological surveys in the Rio Branco Basin, which is entirely in the Brazilian State of Roraima. In this paper, we discuss the presence of 20 bird species recorded along the lower Rio Branco, 16 of which represent new records for the State of Roraima and the entire Rio Branco Basin. Among our most interesting records are four species of white-water river specialists (Synallaxis propinqua, Stigmatura napensis, Serpophaga hypoleuca, and Conirostrum bicolor) that have populations on the lower Rio Branco, isolated from other Amazonian white-water river systems by the black waters of the Rio Negro where they do not occur. We also discovered new localities for the endemic and endangered Rio Branco Antbird (Cercomacra carbonaria), doubling the size of its known range. We discuss the implications of th...

O trabalho foi definido tendo como objetivo discutir e explicitar algumas das diferenças existentes, quanto ao acesso à informação e à comunicação, entre aquelas pessoas que, embora possuam deficiências semelhantes, vivenciam discapacidades diferentes. O recorte metodológico aplicado foca especificamente as pessoas com deficiência visual e as com deficiência auditiva, não simultâneas, com ênfase às pessoas com surdez e às com cegueira. O arcabouço conceitual utilizado é o mesmo que o adotado pela classificação CIF-OMS, sendo o referencial teórico complementado com os aportes de outros autores que desenvolvem estudos relacionados com o tema da discapacidade. Além das pesquisas bibliográficas, integram a metodologia dados coletados em pesquisas de campo, conduzidas em trabalhos anteriores, e os resultantes de observações de pessoas adultas em situações que demandam por acessibilidade à informação e à comunicação. Os resultados encontrados evidenciam a diversidade existente entre as pessoas com um mesmo tipo de deficiência sensorial e assinalam alguns dos equívocos e prejuízos que podem ocorrer quando essa diversidade não é considerada. Ao longo do texto, fica constatado que as diferenças encontradas entre as pessoas com um mesmo tipo de deficiência sensorial são definidas tanto em função de suas preferências individuais, bem como das limitações e capacidades que são peculiares a cada um desses indivíduos.

Philadelphia chromosome (Ph1), which results from the reciprocal translocation t(9;22)(q34;q11), is the hallmark of almost all the cases of chronic myeloid leukemia (CML). Most patients express eit...

Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric manifestations. Chromosomal regions 1q21.1, 3q29, 15q11.2, 15q13.3, 16p11.2, 16p13.1 and 22q11 harbour rare but recurrent CNVs that have been uncovered as being important risk factors for several of these disorders. These rearrangements may underlie a broad phenotypical spectrum, ranging from normal development, to learning problems, intellectual disability (ID), epilepsy and psychiatric diseases, such as autism spectrum disorders (ASDs) and schizophrenia (SZ). The highly increased risk of developing neurodevelopmental phenotypes associated with some of these CNVs makes them an unavoidable element in the clinical context in paediatrics, neurology and psychiatry. However, and although finding these risk loci has been the goal of neuropsychiatric genetics for many years, the translation of this recent knowledge into clinical practice has not been trivial. In this article, we will: (1) review the state of the art on recurrent CNVs associated with NDs, namely ASD, ID, epilepsy and SZ; (2) discuss the models used to dissect the underlying neurobiology of disease, (3) discuss how this knowledge can be used in clinical practice., FEDER through the Programa Operacional Factores de Competitividade — COMPETE and by Portuguese national funds through Fundação para a Ciência e Tecnologia

Abordam-se aspectos referentes à usabilidade e acessibilidade de conteúdos digitais multimídia. São analisados os princípios do projeto de produtos baseados na usabilidade que se aplicam à produção desses documentos digitais, inovando-se ao interpretar os princípios de usabilidade sob o enfoque da acessibilidade. Os cuidados que devem ser tomados para que os documentos digitais adquiram as qualidades da usabilidade e da acessibilidade são assinalados. Uma ênfase especial é dada às situações relacionadas à interação, mediante a utilização de ajudas técnicas, com a informação disponibilizada no espaço digital. Palavras-chave Conteúdos digitais; Acessibilidade; Usabilidade; Ajudas técnicas; Sistemas de leitura de tela; Espaço digital. Multimedia digital contents: an approach on usability and accessibility Abstract Aspects related to the usability and accessibility of multimedia digital contents are discussed. The principles of the project of products, based on the usability are analyzed and considered with reference to the application of the same ones to production of digital documents. The innovation consists in the interpretation of the usability principles under the focus of the accessibility. The cares which must be taken for the digital documents to have usability and accessibility quality are pointed out. A special emphasis is laid on the situations related to the interaction, by use of technical aids, with information which are available in the digital space. Keywords Digital contents; Accessibility; Usability; Technical aids; Screen readers, Digital space.

O trabalho aborda aspectos referentes à acessibilidade no espaço digital. Uma ênfase especial é dada às situações relacionadas à interação das pessoas portadoras de deficiência com a informação, em ambientes de bibliotecas. O texto propõe algumas adequações para a acessibilidade ao espaço digital, conforme categorias de usuários, com o intuito de contribuir para um maior nível de acessibilidade à informação, nesse espaço. The work approaches aspects concerning to the accessibility in the digital space. A special emphasis is given to the situations related to the persons with disabilities and their interaction with the information, in libraries's environment. The text proposes some adaptations for the accessibility to the digital space, according to users' categories and has the intention of contributing for a larger accessibility level to the information, in that space.

Este trabalho surge da tentativa de compreender estratégias formais e informais de triagem dos públicos escolares dentro da própria organização escolar. Surge também da constatação empírica de que os alunos que os professores incluem no conceito de aluno ideal pertencem a escalões superiores da estrutura social, são alunos que não põem em causa a eficácia das técnicas de trabalho dos professores e que correspondem à sua própria definição de sucesso. Na verdade, existiu sempre uma dicotomização nas representações sociais, positivas para o ensino liceal e estigmatizantes para o ensino técnico-profissional bem como uma correlação clara entre o nível de instrução dos pais e a frequência do ensino profissional pelos filhos. Sendo que os recursos se encontram distribuídos de modo socialmente muito desigual, apesar de tudo se passar num quadro normativo formalmente igualitário, a democratização da educação não pode limitar-se à garantia de acesso igual para todos. Cabe às organizações escolares não ignorarem as necessidades e legítimas aspirações das classes socialmente desfavorecidas que se resumem a confiar que a escola não renuncie ao seu papel na aproximação possível à igualdade de oportunidades. A aposta numa correta orientação, divulgação e dignificação de toda a oferta formativa pode surgir, enquanto medida organizacional, como resposta direcionada à heterogeneidade dos alunos. This work arises from the attempt to understand formal and informal screening strategies of public school within the school organization. Also arises from the empirical observation that the students that teachers include in the concept of ideal student belong to the upper echelons of the social structure, are students who do not question the effectiveness of the technical work of teachers and match your own definition of success. In fact, there was always a dichotomy in social representations, positive for secondary education and stigmatizing for technical and vocational education, as well as a clear correlation between the level of parental education and the frequency of vocational education for their children. Once resources are distributed very unevenly socially, despite everything happens in a framework formally egalitarian, democratization of education can’t be limited to ensuring equal access for all. It is up to school organizations not to ignore the needs and legitimate aspirations of socially disadvantaged classes that boil down to trust that the school does not renounce its role in possible approach to equal opportunities. A bet on a correct orientation, disclosure and dignity of all educational supply may arise while organizational measure as a response directed to the heterogeneity of students.

Despite the success of imatinib mesylate (IM) in the treatment of chronic myeloid leukemia (CML), approximately 30% of patients are resistant to therapy, mostly due to unknown causes. To profile the expression signatures of drug transporters throughout IM therapy and correlate them with resistance, we quantified mRNA expression levels of the SLC22A12, ABCB1, ABCC1, ABCG2 and MVP genes in consecutive samples from peripheral blood or bone marrow of CML patients who were either responsive or resistant to IM. Additionally we identified and quantified BCR-ABL1 transcript variants and analyzed 1236TC ABCB1 and 480GC SLC22A1 polymorphisms. A relationship between the type of BCR-ABL1 transcript or ABCB1 or SLC22A1 genotype and response to treatment was not discovered. However, the studied genes had higher expression levels in follow-up compared to the diagnostic samples, demonstrating a possible induction in expression. IM-sensitive patients presented significantly higher values of SLC22A1 expression, suggesting higher drug influx. Most importantly, while responding patients demonstrated stable expression signatures in consecutive samples, there was considerable variation in IM-resistant patients, indicating that single point sampling expression signatures are not reliable in predicting clinical outcomes or prognostic features in these patients. Studies that assessed consecutive samples from CML patients in order to evaluate the variation in expression levels of transporter genes are limited yet our study emphasizes the importance of such approaches.

Resistance to imatinib in patients with chronic myeloid leukemia can lead to advanced disease and blast crisis. Conventional chemotherapy with DNA damaging agents is then used, alone or in combination with other tyrosine kinase inhibitors (TKIs). Our aim was to assess whether imatinib resistant K562 cells were also resistant to DNA damaging agents. After treatment with H 2 O 2 and doxorubicin, but not camptothecin, cell survival was higher in imatinib resistant cells compared to parental cells. DNA damage, measured by comet and g -H2AX assays, was lower in imatinib resistant cells. mRNA expression levels of 50 genes of the DNA damage response pathway showed increased expression of the base excision repair (BER) genes MBD4 and NTHL1 . Knockdown of MBD4 and NTHL1 expression in resistant cells using siRNA decreased cell survival after treatment with H 2 O 2 and doxorubicin. Our results indicate that imatinib resistant cells display cross-resistance to oxidative agents, partly through upregulation of BER genes. Expression of these genes in imatinib resistant patients was not signifi cantly diff erent compared to sensitive patients. However, the strategy followed in this study could help identify chemotherapeutic agents that are more eff ective as alternative agents in cases of resistance to TKIs.

O trabalho foca alguns aspectos relativos à usabilidade e acessibilidade de caixas bancários de auto-atendimento (CAA), aspectos esses que ficam evidenciados como sendo problemas quando os usuários são pessoas idosas e, como tais, podem ter implicações sobre a saúde e os estados de saúde dos mesmos. A pesquisa foi conduzida tendo como objeto de análise os CAA instalados em agências de dois bancos estatais, tendo sido a interação dos usuários avaliada utilizando-se metodologia de análise quantitativa, através de uma amostra constituída por 70 clientes idosos. A pesquisa de campo demonstrou que, nas situações de interação com os CAA, prevalecem os estados de intranqüilidade entre os usuários idosos, e que esses usuários estão expostos a uma grande carga psíquica. O estudo discrimina tanto algumas das características negativas que foram observadas nesses ambientes, bem como adverte porque essas características são desfavoráveis para as pessoas idosas. Além disso, assinala para a necessidade de aperfeiçoamentos nesses serviços, bem como para o desenvolvimento de pesquisas que avaliem o impacto dessa carga psíquica sobre a saúde das pessoas idosas.

This study focuses on some aspects related to the usability and accessibility of automated teller machines (ATM), identified as problematic for elderly users. Some of these problems can interfere with the health and the health status of these users. This study was carried out in two ATMs installed in agencies of two public bank institutions. The interaction of the users with the ATMs was evaluated by quantitative analysis, using a sample of 70 aged customers. The results demonstrated that the elderly felt uneasy using the ATMs, suffering great psychic pressure. This study not only rejects some of the negative characteristics observed in these environments but also alerts to their unfavorable impacts upon the health of the elderly. Moreover, it points to the need for improving these services and for investigations evaluating the impact of the psychic pressure upon the health of elderly people.

The Brazilian state of Roraima represents a meaningful biogeographical unit, enclosing the entire basin of the Rio Branco, a major river in the Amazon basin. Roraima is also an area of high habitat diversity where terra fi rme forest, seasonally fl ooded forest, white-sand forest, savanna, gallery and dry forest, and the vegetation associated with the tepuis, all occur within a relatively small area (225,000km2) by Amazonian standards. We provide the fi rst comprehensive compilation of the avifauna of the state in forty years. We integrated the results of our own fi eld work, where we recorded 512 bird species, with data gathered from museum specimens and from published sources. We present a list of 741 bird species for the state of Roraima, 38 of which are mentioned for the fi rst time for the state. We also provide a list of 15 species previously cited for Roraima that we consider hypothetical, and predict the presence of another 69 species that we consider likely to be recorded in the state with further fi eld work. We also present details on some of our most interesting records, which include the fi rst Brazilian specimen of Atalotriccus pilaris, and the second locality for Brazil of Myrmeciza disjuncta. We conclude that habitat heterogeneity (beta-diversity) is responsible for 60% of the avian diversity of Roraima, whereas regional endemism (gamma-diversity) accounts for about one third of the bird species occurring exclusively in terra fi rme forests. We analyze the biogeographical patterns of avian distributions within the state, in relation to the different habitats present in Roraima, and discuss some of the main conservation problems in the state of Roraima, driven by the expansion of monocultures such as soybean, acacia, and rice plantations which are putting at risk large expanses of savannas, wetlands, dry and gallery forests.

Apresenta-se a evolução do conceito da acessibilidade, inicialmente associado apenas ao projeto livre de barreiras, para o que é hoje conhecido como desenho para todos, envolvendo aspectos tanto do mundo físico como do mundo digital. Discute-se a importância de as bibliotecas universitárias adotarem critérios de acessibilidade, contribuindo para isso o espaço digital. A partir do estudo de caso feito em uma universidade federal brasileira específica, focado nos aspectos de acesso à informação e comunicação e aspectos atitudinais, são elaboradas propostas de melhorias para as condições de acessibilidade em bibliotecas universitárias. This paper presents the evolution of acessibility concept, firstly associated only with barrers-free projects to what is known as universal design and involves several aspects from fisical world and from digital world as well. It argues for how important is the adoption of acessibility criteria by pubic universities. From a case study at a Brasilian Federal University, focusing the aspects of information access, communication and attitude, improvements are proposed for the acessibility of public universities as a whole.

This research aimed to analyze the differential performance visomotoras, verbal and non-verbal tasks, students late in literacy, classified according to different causal factors, based on the existence of advance neuropathological. They were taken as a proposed 84 children of both sexes, aged 9-15 years. These children were divided into three groups (two experimental and one control) and subjected to a battery of tests visomotoras skills, verbal and non - verbal. The results showed no significant differences in performance between groups of children with learning disorders. With or without traumatic history in most tasks, contrary to that, that the estimates of many researchers specifically, in this case, the assumptions Bannatyne (1971) for differential analysis of performance in these tests by children without neurological antecedents. However, if observed through evaluations, remarkable performance differences between the groups of children considered without learning problems and those problems. It was found also that some tests have shown a greater discriminatory power than others. In conclusion, despite some counter predictions Bannatyme and especially the assumptions that support a lower performance for children with learning problems, with a history with neuropathological dysfunction history, in verbal visomotoras tasks and non - verbal. There is also the feasibility of using some of these measures in the students classification with learning disorders. Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq Esta pesquisa teve como objetivo geral analisar o desempenho diferencial em tarefas visomotoras, verbais e não verbais, de alunos com atraso na alfabetização, classificados segundo diferentes fatores causais, baseados na existência de antecedência de neuropatológicos. Tomaram-se como proposta 84 crianças de ambos os sexos, na faixa etária de 9 a 15 anos. Estas crianças foram divididas em três grupos ( dois experimentais e um de controle) e submetidas a uma bateria de testes de habilidades visomotoras, verbais e não – verbais. A análise dos resultados não apresentou diferenças significativas de desempenho entre os grupos de crianças com distúrbios de aprendizagem. Com ou sem antecedentes traumáticos, na maioria das tarefas, contrariando assim, assim, as previsões de vários estudiosos, especificamente, neste caso, os pressupostos de Bannatyne (1971) sobre a análise diferencial dos desempenho, nos referidos testes, por parte das crianças sem antecedentes neurológicos. No entanto, observaram-se, através de avaliações realizadas, marcantes diferenças de desempenho entre os grupos de crianças consideradas sem problemas de aprendizagem e aquelas com problemas. Verificou-se, ainda, que alguns testes mostraram maior poder discriminatório que outros. Conclui-se que, apesar de contrariar algumas previsões de Bannatyme e principalmente as hipóteses que apoiam um desempenho inferior para as crianças com problemas de aprendizagem, com antecedentes com antecedentes de disfunção neuropatológica, nas tarefas visomotoras verbais e não – verbais. Há também a viabilidade de se utilizarem algumas destas medidas na classificação de alunos com distúrbios de aprendizagem.

A 13-year-old boy, born prematurely and hypotonic, from non-consanguineous healthy parents, was referred to our department because of easy bruising. A slightly extensible, thin and translucent skin, associated with dysmorphic facies, acrogeria, multiple ecchymoses, hypermobility of the small joints, dorsal kyphosis, genu valgum, flat feet, elongated upper limbs, and low muscle tone were all evident. A history of learning disability and bilateral inguinal hernia was present. Blood and imaging studies were unremarkable. A skin biopsy disclosed an unremarkable dermis; electron microscopy showed abnormalities in the diameter, contour, and shape of collagen fibrils/fibers. Genetic analysis revealed heterozygosity for a novel mutation in COL3A1 gene (c.3527G>A), confirming the diagnosis of vascular Ehlers-Danlos syndrome (VEDS). The patient died at 15 years of age because of aortic dissection. Vascular Ehlers-Danlos syndrome is a rare, life-threatening, autosomal dominant variant of EDS, resulting from mutations in COL3A1 gene. Affected individuals are prone to serious and potentially fatal complications, especially vascular, intestinal, and uterine ruptures. Delay in diagnosis is common, even when the clinical presentation is typical. Therefore, dermatologists should be familiar with VEDS features because the skin findings may be the first signs. Early diagnosis will improve management of visceral complications and allow early genetic counseling.