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1. Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study

Author

Desalegn, Anteneh, Schillemans, Tessa, Papadopoulou, Eleni, Sakhi, Amrit K., Haug, Line S., Henriette Caspersen, Ida, Rodriguez-Carrillo, Andrea, Remy, Sylvie, Schoeters, Greet, Covaci, Adrian, Laeremans, Michelle, Fernández, Mariana F, Pedraza-Diaz, Susana, Kold Jensen, Tina, Frederiksen, Hanne, Åkesson, Agneta, Cox, Bianca, Cynthia D’Cruz, Shereen, Rambaud, Loïc, Riou, Margaux, Kolossa-Gehring, Marike, Gerofke, Antje, Murawski, Aline, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Dimosthenis, Barbone, Fabio, Rosolen, Valentina, Lignell, Sanna, Karin Lindroos, Anna, Snoj Tratnik, Janja, Stajnko, Anja, Kosjek, Tina, Tkalec, Žiga, Fabelova, Lucia, Palkovicova Murinova, Lubica, Kolena, Branislav, Wimmerova, Sona, Szigeti, Tamás, Középesy, Szilvia, van den Brand, Annick, Zock, Jan-Paul, Janasik, Beata, Wasowicz, Wojciech, De Decker, Annelies, De Henauw, Stefaan, Govarts, Eva, and Iszatt, Nina

Published
2024
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2. Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Remy, Sylvie, Koppen, Gudrun, Wauters, Natasha, Mustieles, Vicente, Desalegn, Anteneh, Iszatt, Nina, den Hond, Elly, Verheyen, Veerle J., Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Esteban, Marta, Poyatos, Rafael M., Govarts, Eva, van Nuijs, Alexander L.N., Covaci, Adrian, Schoeters, Greet, Olea, Nicolás, and Fernández, Mariana F.

Published
2024
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3. Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Salamanca-Fernández, Elena, den Hond, Elly, Verheyen, Veerle J., Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Remy, Sylvie, Govarts, Eva, Schoeters, Greet, Olea, Nicolás, Freire, Carmen, and Fernández, Mariana F.

Published
2023
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4. PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Remy, Sylvie, Koppen, Gudrun, Wauters, Natasha, Freire, Carmen, Olivas-Martínez, Alicia, Schillemans, Tessa, Åkesson, Agneta, Desalegn, Anteneh, Iszatt, Nina, den Hond, Elly, Verheyen, Veerle, Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Cox, Bianca, Govarts, Eva, Baken, Kirsten, Tena-Sempere, Manuel, Olea, Nicolás, Schoeters, Greet, and Fernández, Mariana F.

Published
2023
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5. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet

Published
2023
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6. Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021

Author

Vogel, Nina, Schmidt, Phillipp, Lange, Rosa, Gerofke, Antje, Sakhi, Amrit K., Haug, Line S., Jensen, Tina Kold, Frederiksen, Hanne, Szigeti, Tamás, Csákó, Zsófia, Murinova, Lubica Palkovicova, Sidlovska, Miroslava, Janasik, Beata, Wasowicz, Wojciech, Tratnik, Janja Snoj, Mazej, Darja, Gabriel, Catherine, Karakitsios, Spyros, Barbone, Fabio, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Murawski, Aline, Leseman, Daan, Koppen, Gudrun, Covaci, Adrian, Lignell, Sanna, Lindroos, Anna Karin, Zvonar, Martin, Andryskova, Lenka, Fabelova, Lucia, Richterova, Denisa, Horvat, Milena, Kosjek, Tina, Sarigiannis, Denis, Maroulis, Marios, Pedraza-Diaz, Susana, Cañas, Ana, Verheyen, Veerle J., Bastiaensen, Michiel, Gilles, Liese, Schoeters, Greet, Esteban-López, Marta, Castaño, Argelia, Govarts, Eva, Koch, Holger M., and Kolossa-Gehring, Marike

Published
2023
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7. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Published
2023
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8. Exposure to flame retardants in European children — Results from the HBM4EU aligned studies

Author

van der Schyff, Veronica, Kalina, Jiři, Govarts, Eva, Gilles, Liese, Schoeters, Greet, Castaño, Argelia, Esteban-López, Marta, Kohoutek, Jiři, Kukučka, Petr, Covaci, Adrian, Koppen, Gudrun, Andrýsková, Lenka, Piler, Pavel, Klánová, Jana, Jensen, Tina Kold, Rambaud, Loic, Riou, Margaux, Lamoree, Marja, Kolossa-Gehring, Marike, Vogel, Nina, Weber, Till, Göen, Thomas, Gabriel, Catherine, Sarigiannis, Dimosthenis A., Sakhi, Amrit Kaur, Haug, Line Småstuen, Murinova, Lubica Palkovicova, Fabelova, Lucia, Tratnik, Janja Snoj, Mazej, Darja, and Melymuk, Lisa

Published
2023
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9. Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

Author

Schillemans, Tessa, Iszatt, Nina, Remy, Sylvie, Schoeters, Greet, Fernández, Mariana F., D'Cruz, Shereen Cynthia, Desalegn, Anteneh, Haug, Line S., Lignell, Sanna, Lindroos, Anna Karin, Fábelová, Lucia, Murinova, Lubica Palkovicova, Kosjek, Tina, Tkalec, Žiga, Gabriel, Catherine, Sarigiannis, Denis, Pedraza-Díaz, Susana, Esteban-López, Marta, Castaño, Argelia, Rambaud, Loïc, Riou, Margaux, Pauwels, Sara, Vanlarebeke, Nik, Kolossa-Gehring, Marike, Vogel, Nina, Uhl, Maria, Govarts, Eva, and Åkesson, Agneta

Published
2023
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10. Cumulative risk assessment of five phthalates in European children and adolescents

Author

Lange, Rosa, Vogel, Nina, Schmidt, Phillipp, Gerofke, Antje, Luijten, Mirjam, Bil, Wieneke, Santonen, Tiina, Schoeters, Greet, Gilles, Liese, Sakhi, Amrit K., Haug, Line S., Jensen, Tina K., Frederiksen, Hanne, Koch, Holger M., Szigeti, Tamás, Szabados, Máté, Tratnik, Janja Snoj, Mazej, Darja, Gabriel, Catherine, Sarigiannis, Dimosthenis, Dzhedzheia, Vazha, Karakitsios, Spyros, Rambaud, Loïc, Riou, Margaux, Koppen, Gudrun, Covaci, Adrian, Zvonař, Martin, Piler, Pavel, Klánová, Jana, Fábelová, Lucia, Richterová, Denisa, Kosjek, Tina, Runkel, Agneta, Pedraza-Díaz, Susana, Verheyen, Veerle, Bastiaensen, Michiel, Esteban-López, Marta, Castaño, Argelia, and Kolossa-Gehring, Marike

Published
2022
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11. Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies.

Author

Salamanca-Fernández, Elena, Espín-Moreno, Lydia, Olivas-Martínez, Alicia, Pérez-Cantero, Ainhoa, Martín-Rodríguez, José L., Poyatos, Rafael M., Barbone, Fabio, Rosolen, Valentina, Mariuz, Marika, Ronfani, Luca, Palkovičová Murínová, Ľubica, Fábelová, Lucia, Szigeti, Tamás, Kakucs, Réka, Sakhi, Amrit K., Haug, Line S., Lindeman, Birgitte, Snoj Tratnik, Janja, Kosjek, Tina, and Jacobs, Griet

Subjects
CHILD Behavior Checklist, BRAIN-derived neurotrophic factor, INTERNALIZING behavior, REGRESSION analysis, METABOLITES, PHTHALATE esters
Abstract

Based on toxicological evidence, children's exposure to phthalates may contribute to altered neurodevelopment and abnormal regulation of brain-derived neurotrophic factor (BDNF). We analyzed data from five aligned studies of the Human Biomonitoring for Europe (HBM4EU) project. Ten phthalate metabolites and protein BDNF levels were measured in the urine samples of 1148 children aged 6–12 years from Italy (NACII-IT cohort), Slovakia (PCB-SK cohort), Hungary (InAirQ-HU cohort) and Norway (NEBII-NO). Serum BDNF was also available in 124 Slovenian children (CRP-SLO cohort). Children's total, externalizing and internalizing behavioral problems were assessed using the Child Behavior Checklist at 7 years of age (only available in the NACII-IT cohort). Adjusted linear and negative binomial regression models were fitted, together with weighted quantile sum (WQS) regression models to assess phthalate mixture associations. Results showed that, in boys but not girls of the NACII-IT cohort, each natural-log-unit increase in mono-n-butyl phthalate (MnBP) and Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) was cross-sectionally associated with higher externalizing problems [incidence rate ratio (IRR): 1.20; 95% CI: 1.02, 1.42 and 1.26; 95% CI: 1.03, 1.55, respectively]. A suggestive mixture association with externalizing problems was also observed per each tertile mixture increase in the whole population (WQS—IRR = 1.15; 95% CI: 0.97, 1.36) and boys (IRR = 1.20; 95% CI: 0.96, 1.49). In NACII-IT, PCB-SK, InAirQ-HU and NEBII-NO cohorts together, urinary phthalate metabolites were strongly associated with higher urinary BDNF levels, with WQS regression confirming a mixture association in the whole population (percent change (PC) = 25.9%; 95% CI: 17.6, 34.7), in girls (PC = 18.6%; 95% CI: 7.92, 30.5) and mainly among boys (PC = 36.0%; 95% CI: 24.3, 48.9). Among CRP-SLO boys, each natural-log-unit increase in ∑DINCH concentration was associated with lower serum BDNF levels (PC: −8.8%; 95% CI: −16.7, −0.3). In the NACII-IT cohort, each natural-log-unit increase in urinary BDNF levels predicted worse internalizing scores among all children (IRR: 1.15; 95% CI: 1.00, 1.32). Results suggest that (1) children's exposure to di-n-butyl phthalate (DnBP) and di(2-ethylhexyl) phthalate (DEHP) metabolites is associated with more externalizing problems in boys, (2) higher exposure to DINCH may associate with lower systemic BDNF levels in boys, (3) higher phthalate exposure is associated with higher urinary BDNF concentrations (although caution is needed since the possibility of a "urine concentration bias" that could also explain these associations in noncausal terms was identified) and (4) higher urinary BDNF concentrations may predict internalizing problems. Given this is the first study to examine the relationship between phthalate metabolite exposure and BDNF biomarkers, future studies are needed to validate the observed associations. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Exposure to Phthalates in European Children, Adolescents and Adults since 2005:A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author

Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., Kolossa-Gehring, Marike, Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., and Kolossa-Gehring, Marike

Abstract

Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across Europe is challenging. They differ widely in time periods, study samples, degree of geographical coverage, design, analytical methodology, biomarker selection, and analytical quality assurance level. The HBM4EU initiative has gathered existing HBM data of 29 studies from participating countries, covering all European regions and Israel. The data were prepared and aggregated by a harmonized procedure with the aim to describe—as comparably as possible—the EU-wide general population’s internal exposure to phthalates from the years 2005 to 2019. Most data were available from Northern (up to 6 studies and up to 13 time points), Western (11; 19), and Eastern Europe (9; 12), e.g., allowing for the investigation of time patterns. While the bandwidth of exposure was generally similar, we still observed regional differences for Butyl benzyl phthalate (BBzP), Di(2-ethylhexyl) phthalate (DEHP), Di-isononyl phthalate (DiNP), and Di-isobutyl phthalate (DiBP) with pronounced decreases over time in Northern and Western Europe, and to a lesser degree in Eastern Europe. Differences between age groups were visible for Di-n-butyl phthalate (DnBP), where children (3 to 5-year olds and 6 to 11-year olds) had lower urinary concentrations than adolescents (12 to 19-year-olds), who in turn had lower urinary concentrations than adults (20 to 39-year-olds). This study is a step towards making internal exposures to phthalates comparable across countries, although standardized data were not available, targeting European data sets harmonized with respect to data formatting and calculation of aggregated data (such as develope

Published
2023

18. Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author

Vogel, Nina, primary, Lange, Rosa, additional, Schmidt, Phillipp, additional, Rodriguez Martin, Laura, additional, Remy, Sylvie, additional, Springer, Andrea, additional, Puklová, Vladimíra, additional, Černá, Milena, additional, Rudnai, Péter, additional, Középesy, Szilvia, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Fábelová, Lucia, additional, Kolena, Branislav, additional, Petrovicova, Ida, additional, Jajcaj, Michal, additional, Eštóková, Milada, additional, Esteban-Lopez, Marta, additional, Castaño, Argelia, additional, Tratnik, Janja Snoj, additional, Stajnko, Anja, additional, Knudsen, Lisbeth E., additional, Toppari, Jorma, additional, Main, Katharina M., additional, Juul, Anders, additional, Andersson, Anna-Maria, additional, Jørgensen, Niels, additional, Frederiksen, Hanne, additional, Thomsen, Cathrine, additional, Sakhi, Amrit Kaur, additional, Åkesson, Agneta, additional, Hartmann, Christina, additional, Dewolf, Marie Christine, additional, Koppen, Gudrun, additional, Biot, Pierre, additional, Den Hond, Elly, additional, Voorspoels, Stefan, additional, Gilles, Liese, additional, Govarts, Eva, additional, Murawski, Aline, additional, Gerofke, Antje, additional, Weber, Till, additional, Rüther, Maria, additional, Gutleb, Arno C., additional, Guignard, Cedric, additional, Berman, Tamar, additional, Koch, Holger M., additional, and Kolossa-Gehring, Marike, additional

Published
2023
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19. PFAS Association with Kisspeptin and Sex Hormones in Teenagers of the HBM4EU Aligned Studies

Author

Rodríguez-Carrillo, Andrea, primary, Remy, Silvie, additional, Koppen, Gudrun, additional, Wauters, Natasha, additional, Freire, Carmen, additional, Olivas-Martínez, Alicia, additional, Schillemans, Tessa, additional, Akesson, Agneta, additional, Desalegn, Anteneh, additional, Iszatt, Nina, additional, Hond, Elly den, additional, Verheyen, Veerle J., additional, Fábelová, Lucia, additional, Murinova, Lubica Palkovicova, additional, Díaz, Susana Pedraza, additional, Castano, Argelia, additional, García-Lario, José Vicente, additional, Cox, Bianca, additional, Govarts, Eva, additional, Baken, Kirsten, additional, Tena-Sempere, Manuel, additional, Olea, Nicolás, additional, Schoeters, Greet, additional, and Fernández, Mariana F., additional

Published
2023
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21. Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

Author

Gilles, Liese, primary, Govarts, Eva, additional, Rodriguez Martin, Laura, additional, Andersson, Anna-Maria, additional, Appenzeller, Brice M. R., additional, Barbone, Fabio, additional, Castaño, Argelia, additional, Coertjens, Dries, additional, Den Hond, Elly, additional, Dzhedzheia, Vazha, additional, Eržen, Ivan, additional, López, Marta Esteban, additional, Fábelová, Lucia, additional, Fillol, Clémence, additional, Franken, Carmen, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Haug, Line Småstuen, additional, Horvat, Milena, additional, Halldórsson, Thórhallur Ingi, additional, Janasik, Beata, additional, Holcer, Nataša Janev, additional, Kakucs, Réka, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klánová, Jana, additional, Kold-Jensen, Tina, additional, Kolossa-Gehring, Marike, additional, Konstantinou, Corina, additional, Koponen, Jani, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Morrens, Bert, additional, Murínová, Ľubica Palkovičová, additional, Namorado, Sónia, additional, Pedraza-Diaz, Susana, additional, Peisker, Jasmin, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rosolen, Valentina, additional, Rucic, Enrico, additional, Rüther, Maria, additional, Sarigiannis, Dimosthenis, additional, Tratnik, Janja Snoj, additional, Standaert, Arnout, additional, Stewart, Lorraine, additional, Szigeti, Tamás, additional, Thomsen, Cathrine, additional, Tolonen, Hanna, additional, Eiríksdóttir, Ása, additional, Van Nieuwenhuyse, An, additional, Verheyen, Veerle J., additional, Vlaanderen, Jelle, additional, Vogel, Nina, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Zock, Jan-Paul, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional

Published
2022
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23. Prenatal Exposure to Food Chemicals and Cognitive Development in Pre-School Aged Children from the EDEN Mother-Child Cohort

Author

Fábelová, Lucia, primary, Kadawathagedara, Manik, additional, Traoré, Thiéma, additional, Sirot, Véronique, additional, Forhan, Anne, additional, Bernard, Jonathan Y., additional, Charles, Marie-Aline, additional, de Lauzon-Guillain, Blandine, additional, Heude, Barbara, additional, and Botton, Jérémie, additional

Published
2018
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24. Associations of Bedtime Schedules in Childhood with Obesity Risk in Adolescence

Author

Mireku, Michael Osei, Fábelová, Lucia, Mireku, Michael Osei, and Fábelová, Lucia

Abstract

We investigated whether bedtime schedules and bedtimes in childhood were associated with obesity risk and adiposity in adolescence. We analysed the data of 12,645 singleton children classified as not obese at 7 years from the Millennium Cohort Study in the United Kingdom. Bedtimes and the regularity of bedtimes of 7-year-olds were reported by parents. Bio-electric impedance body fat percentage (BFP) measurements and obesity at 11 and 14 years were the considered outcomes. The International Obesity Task Force age- and sex-specific thresholds were used to define obesity. Obesity risk at 11 and 14 years was higher among children with never-regular bedtimes at 7 years compared with those with always-regular bedtimes (risk ratio, RR, 2.8 (95% CI, 1.8–1.4) and 2.3 (95% CI, 1.5–3.6), respectively). An increasing irregularity in childhood bedtime was associated with an increasing risk of obesity at both 11 and 14 years in a dose–response manner (p trend < 0.001; and p trend = 0.002, respectively). BFP at 11 years increased by 1.1% (95% CI, 0.8–1.5) for boys and 1.0% (95% CI, 0.6–1.4) for girls for every hour delay in childhood bedtime. Irregular bedtime schedules and later bedtimes in childhood were associated with an increased risk of obesity in early- and mid-adolescence in a dose–response manner. There was marginal, but significant, increases in BFP during adolescence for children with later bedtimes.

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