Author: "F, Francesca" - Searchworks@Jio Institute Digital Library Search Results

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1. The role of external beam radiation therapy for post prostatectomy stress urinary incontinence in transobturator male sling outcomes. A multicentric experience

Author: S. Morselli, V. Li Marzi, R. Baldesi, R. Fantechi, L. Gemma, A. Liaci, M. Di Camillo, C. Traversi, A. Tosto, F. Francesca, M. Gerolamo, and S. Serni
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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2. Natural history of KBG syndrome in a large European cohort

Author: Loberti, L. (Lorenzo), Bruno, L. P. (Lucia Pia), Granata, S. (Stefania), Doddato, G. (Gabriella), Resciniti, S. (Sara), Fava, F. (Francesca), Carullo, M. (Michele), Rahikkala, E. (Elisa), Jouret, G. (Guillaume), Menke, L. A. (Leonie A.), Lederer, D. (Damien), Vrielynck, P. (Pascal), Ryba, L. (Lukáš), Brunetti-Pierri, N. (Nicola), Lasa-Aranzasti, A. (Amaia), Cueto-González, A. M. (Anna Maria), Trujillano, L. (Laura), Valenzuela, I. (Irene), Tizzano, E. F. (Eduardo F.), Spinelli, A. M. (Alessandro Mauro), Bruno, I. (Irene), Currò, A. (Aurora), Stanzial, F. (Franco), Benedicenti, F. (Francesco), Lopergolo, D. (Diego), Santorelli, F. M. (Filippo Maria), Aristidou, C. (Constantia), Tanteles, G. A. (George A.), Maystadt, I. (Isabelle), Tkemaladze, T. (Tinatin), Reimand, T. (Tiia), Lokke, H. (Helen), Õunap, K. (Katrin), Haanpää, M. K. (Maria K.), Holubová, A. (Andrea), Zoubková, V. (Veronika), Schwarz, M. (Martin), Žordania, R. (Riina), Muru, K. (Kai), Roht, L. (Laura), Tihveräinen, A. (Annika), Teek, R. (Rita), Thomson, U. (Ulvi), Atallah, I. (Isis), Superti-Furga, A. (Andrea), Buoni, S. (Sabrina), Canitano, R. (Roberto), Scandurra, V. (Valeria), Rossetti, A. (Annalisa), Grosso, S. (Salvatore), Battini, R. (Roberta), Baldassarri, M. (Margherita), Mencarelli, M. A. (Maria Antonietta), Lo Rizzo, C. (Caterina), Bruttini, M. (Mirella), Mari, F. (Francesca), Ariani, F. (Francesca), Renieri, A. (Alessandra), Pinto, A. M. (Anna Maria), Loberti, L. (Lorenzo), Bruno, L. P. (Lucia Pia), Granata, S. (Stefania), Doddato, G. (Gabriella), Resciniti, S. (Sara), Fava, F. (Francesca), Carullo, M. (Michele), Rahikkala, E. (Elisa), Jouret, G. (Guillaume), Menke, L. A. (Leonie A.), Lederer, D. (Damien), Vrielynck, P. (Pascal), Ryba, L. (Lukáš), Brunetti-Pierri, N. (Nicola), Lasa-Aranzasti, A. (Amaia), Cueto-González, A. M. (Anna Maria), Trujillano, L. (Laura), Valenzuela, I. (Irene), Tizzano, E. F. (Eduardo F.), Spinelli, A. M. (Alessandro Mauro), Bruno, I. (Irene), Currò, A. (Aurora), Stanzial, F. (Franco), Benedicenti, F. (Francesco), Lopergolo, D. (Diego), Santorelli, F. M. (Filippo Maria), Aristidou, C. (Constantia), Tanteles, G. A. (George A.), Maystadt, I. (Isabelle), Tkemaladze, T. (Tinatin), Reimand, T. (Tiia), Lokke, H. (Helen), Õunap, K. (Katrin), Haanpää, M. K. (Maria K.), Holubová, A. (Andrea), Zoubková, V. (Veronika), Schwarz, M. (Martin), Žordania, R. (Riina), Muru, K. (Kai), Roht, L. (Laura), Tihveräinen, A. (Annika), Teek, R. (Rita), Thomson, U. (Ulvi), Atallah, I. (Isis), Superti-Furga, A. (Andrea), Buoni, S. (Sabrina), Canitano, R. (Roberto), Scandurra, V. (Valeria), Rossetti, A. (Annalisa), Grosso, S. (Salvatore), Battini, R. (Roberta), Baldassarri, M. (Margherita), Mencarelli, M. A. (Maria Antonietta), Lo Rizzo, C. (Caterina), Bruttini, M. (Mirella), Mari, F. (Francesca), Ariani, F. (Francesca), Renieri, A. (Alessandra), and Pinto, A. M. (Anna Maria)
Abstract: KBG syndrome (KBGS) is characterized by distinctive facial gestalt, short stature and variable clinical findings. With ageing, some features become more recognizable, allowing a differential diagnosis. We aimed to better characterize natural history of KBGS. In the context of a European collaborative study, we collected the largest cohort of KBGS patients (49). A combined array- based Comparative Genomic Hybridization and next generation sequencing (NGS) approach investigated both genomic Copy Number Variants and SNVs. Intellectual disability (ID) (82%) ranged from mild to moderate with severe ID identified in two patients. Epilepsy was present in 26.5%. Short stature was consistent over time, while occipitofrontal circumference (median value: −0.88 SD at birth) normalized over years. Cerebral anomalies, were identified in 56% of patients and thus represented the second most relevant clinical feature reinforcing clinical suspicion in the paediatric age when short stature and vertebral/dental anomalies are vague. Macrodontia, oligodontia and dental agenesis (53%) were almost as frequent as skeletal anomalies, such as brachydactyly, short fifth finger, fifth finger clinodactyly, pectus excavatum/carinatum, delayed bone age. In 28.5% of individuals, prenatal ultrasound anomalies were reported. Except for three splicing variants, leading to a premature termination, variants were almost all frameshift. Our results, broadening the spectrum of KBGS phenotype progression, provide useful tools to facilitate differential diagnosis and improve clinical management. We suggest to consider a wider range of dental anomalies before excluding diagnosis and to perform a careful odontoiatric/ear-nose-throat (ENT) evaluation in order to look for even submucosal palate cleft given the high percentage of palate abnormalities. NGS approaches, following evidence of antenatal ultrasound anomalies, should include ANKRD11.
Published: 2022

3. Paediatric rheumatologists do not score the physician’s global assessment of juvenile idiopathic arthritis disease activity in the same way

Author: Backström, M. (Maria), Tarkiainen, M. (Maarit), Gottlieb, B. S. (Beth S), Trincianti, C. (Chiara), Qiu, T. (Tingting), Morgan, E. (Esi), Lovell, D. J. (Daniel J), Bovis, F. (Francesca), Löyttyniemi, E. (Eliisa), Ruperto, N. (Nicolino), Vähäsalo, P. (Paula), Consolaro, A. (Alessandro), Backström, M. (Maria), Tarkiainen, M. (Maarit), Gottlieb, B. S. (Beth S), Trincianti, C. (Chiara), Qiu, T. (Tingting), Morgan, E. (Esi), Lovell, D. J. (Daniel J), Bovis, F. (Francesca), Löyttyniemi, E. (Eliisa), Ruperto, N. (Nicolino), Vähäsalo, P. (Paula), and Consolaro, A. (Alessandro)
Abstract: Objectives: To assess the heterogeneity in factors affecting physician’s global assessment of disease activity (PhGA) and in PhGA scoring of multiple JIA patient’s case scenarios. Methods: An electronic web-based questionnaire of factors potentially considered in PhGA was sent worldwide to members of PRINTO and the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN). The respondents were asked to rate from 0 to 100 the relevance of 17 factors possibly affecting PhGA scoring and to derive a PhGA score of 17 detailed JIA patient cases. The median and interquartile range was used to measure the heterogeneity in the scoring. To demonstrate the consistency among the PhGA scores of the patient cases provided by multiple physicians, we assessed the inter-rater reliability using intra-class correlation. Results: The questionnaire was completed by 491 respondents. A large individual variation was observed in the impact of different factors on PhGA when assessing JIA. For non-systemic JIA the presence of fever had the largest variation and swollen joint count had the smallest. For sJIA, the largest variation was seen in the presence of erosions and the smallest in the presence of fever. The intra-class correlation of the group for PhGA scoring of patient cases was 0.53 (95% CI 0.38, 0.72). Conclusions: In a sample of worldwide respondents, the scoring of the PhGA is divergent. Consensus on PhGA scoring guidelines is required to obtain a consistent assessment of patients.
Published: 2023

4. Seasonal and spatial variation of stream macroinvertebrate taxonomic and functional diversity across three boreal regions

Author: Baker, N. J. (Nathan Jay), Welti, E. A. (Ellen A. R.), Pilotto, F. (Francesca), Jourdan, J. (Jonas), Beudert, B. (Burkhard), Huttunen, K.-L. (Kaisa-Leena), Muotka, T. (Timo), Paavola, R. (Riku), Göthe, E. (Emma), Haase, P. (Peter), Baker, N. J. (Nathan Jay), Welti, E. A. (Ellen A. R.), Pilotto, F. (Francesca), Jourdan, J. (Jonas), Beudert, B. (Burkhard), Huttunen, K.-L. (Kaisa-Leena), Muotka, T. (Timo), Paavola, R. (Riku), Göthe, E. (Emma), and Haase, P. (Peter)
Abstract: 1. The exploration of biodiversity has predominantly been based on taxonomic measures, whereas functional diversity, a key component of biodiversity, is comparatively understudied. Therefore, studies simultaneously investigating patterns of taxonomic and functional diversity change in biological communities are of increasing interest. 2. We collated high-resolution macroinvertebrate and environmental data from 70 boreal headwater stream sites across three European countries (Germany, Finland, Sweden) to (1) investigate seasonal variation in taxonomic diversity, functional diversity, and redundancy, and (2) identify their potential drivers of spatial and seasonal variation. 3. Seasonal changes in boreal macroinvertebrate taxonomic diversity were decoupled from changes in functional diversity. Seasonal shifts in environmental conditions, including acidity and nutrient variability, drove fluctuations in taxonomic diversity which were far more pronounced than those of functional diversity. 4. Seasonal shifts in environmental conditions including variation in the quantity, quality, and state of organic carbon (dissolved vs particulate) facilitate an exchange of taxa, leading to taxonomically unique communities that exploit the pool of available seasonal resources. Thus, similar levels of functional diversity across seasons—even as taxonomic diversity changes—suggest limited differences in interspecific changes in community function, potentially indicating functional resistance rooted in redundancy. 5. We highlight the spatial and seasonal discrepancies of freshwater communities, emphasising the need for both taxonomic and functional diversity patterns to be assessed in future biodiversity monitoring programmes.
Published: 2023

5. A computational model for assessing experts’ trustworthiness

Author: Primiero, G. (Giuseppe), Ceolin, D. (Davide), Doneda, F. (Francesca), Primiero, G. (Giuseppe), Ceolin, D. (Davide), and Doneda, F. (Francesca)
Abstract: The algorithmic detection of disinformation online is currently based on two strategies: on the one hand, research focuses on automated fact-checking; on the other hand, models are being developed to assess the trustworthiness of information sources, including both empirical and theoretical research on credibility and content quality. For debates among experts, in particular, it might be hard to discern (less) reliable information, as all actors by definition are qualified. In these cases, the use of trustworthiness metrics on sources is a useful proxy for establishing the truthfulness of contents. We introduce an algorithmic model for automatically generating a dynamic trustworthiness hierarchy among information sources based on several parameters, including fact-checking. The method is novel and significant, especially in two respects: first, the generated hierarchy represents a helpful tool for laypeople to navigate experts’ debates; second, it also allows to identify and overcome biases generated by intuitive rankings held by agents at the beginning of the debates. We provide an experimental analysis of our algorithmic model applied to the debate on the SARS-CoV-2 virus, which took place among Italian medical specialists between 2020 and 2021.
Published: 2023
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6. Geometric multigrid method for solving Poisson's equation on octree grids with irregular boundaries

Author: Teunissen, H.J. (Jannis), Schiavello, F. (Francesca), Teunissen, H.J. (Jannis), and Schiavello, F. (Francesca)
Abstract: A method is presented to include irregular domain boundaries in a geometric multigrid solver. Dirichlet boundary conditions can be imposed on an irregular boundary defined by a level set function. Our implementation employs quadtree/octree grids with adaptive refinement, a cell-centered discretization and pointwise smoothing. Boundary locations are determined at a subgrid resolution by performing line searches. For grid blocks near the interface, custom operator stencils are stored that take the interface into account. For grid block away from boundaries, a standard second-order accurate discretization is used. The convergence properties, robustness and computational cost of the method are illustrated with several test cases. New version program summary: Program Title: Afivo CPC Library link to program files: https://doi.org/10.17632/5y43rjdmxd.2 Developer's repository link: https://github.com/MD-CWI/afivo Licensing provisions: GPLv3 Programming language: Fortran Journal reference of previous version: Comput. Phys. Commun. 233 (2018) 156–166. https://doi.org/10.1016/j.cpc.2018.06.018 Does the new version supersede the previous version?: Yes. Reasons for the new version: Add support for internal boundaries in the geometric multigrid solver. Summary of revisions: The geometric multigrid solver was generalized in several ways: a coarse grid solver from the Hypre library is used, operator stencils are now stored per grid block, and methods for including boundaries via a level set function were added. Nature of problem: The goal is to solve Poisson's equation in the presence of irregular boundaries that are not aligned with the computational grid. It is assumed these irregular boundaries are defined by a level set function, and that a Dirichlet type boundary condition is applied. The main applications are 2D and 3D simulations with octree-based adaptive mesh refinement, in which the mesh frequently changes but the irregular boundaries do not. Solution method: A geometric
Published: 2023
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7. Surgeons' perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey: results from an international survey

Author: Cobianchi, L. (Lorenzo), Piccolo, D. (Daniele), Dal Mas, F. (Francesca), Agnoletti, V. (Vanni), Ansaloni, L. (Luca), Balch, J. (Jeremy), Biffl, W. (Walter), Butturini, G. (Giovanni), Catena, F. (Fausto), Coccolini, F. (Federico), Denicolai, S. (Stefano), De Simone, B. (Belinda), Frigerio, I. (Isabella), Fugazzola, P. (Paola), Marseglia, G. (Gianluigi), Marseglia, G. (Giuseppe Roberto), Martellucci, J. (Jacopo), Modenese, M. (Mirko), Previtali, P. (Pietro), Ruta, F. (Federico), Venturi, A. (Alessandro), Kaafarani, Haytham M., Loftus, Tyler. J, Mascagni, P. (Pietro), Rodriguez Luna, M. (Maria Rita), and Seeliger, B. (Barbara)
Subjects: Sciences du Vivant [q-bio]/Ingénierie biomédicale
Abstract: BACKGROUND: Artificial intelligence (AI) is gaining traction in medicine and surgery. AI-based applications can offer tools to examine high-volume data to inform predictive analytics that supports complex decision-making processes. Time-sensitive trauma and emergency contexts are often challenging. The study aims to investigate trauma and emergency surgeons' knowledge and perception of using AI-based tools in clinical decision-making processes. METHODS: An online survey grounded on literature regarding AI-enabled surgical decision-making aids was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was advertised to 917 WSES members through the society's website and Twitter profile. RESULTS: 650 surgeons from 71 countries in five continents participated in the survey. Results depict the presence of technology enthusiasts and skeptics and surgeons' preference toward more classical decision-making aids like clinical guidelines, traditional training, and the support of their multidisciplinary colleagues. A lack of knowledge about several AI-related aspects emerges and is associated with mistrust. DISCUSSION: The trauma and emergency surgical community is divided into those who firmly believe in the potential of AI and those who do not understand or trust AI-enabled surgical decision-making aids. Academic societies and surgical training programs should promote a foundational, working knowledge of clinical AI.
Published: 2023

8. Modulating T Cell Responses by Targeting CD3

Author: Menon, A.P. (Ashwathi Puravankara), Moreno, B. (Beatriz), Meraviglia-Crivelli, D. (Daniel), Nonatelli, F. (Francesca), Villanueva-Ruiz, M.E. (María Elena), Barainka, M. (Martin), Zheleva, A. (Angelina), van-Santen, H.M. (Hisse M.), and Pastor, F. (Fernando)
Subjects: T cell engager, Cancer immunotherapy, T cell modulation, CD3, Aptamers, TCR, Antibodies
Abstract: Simple Summary CD3 complex provides the first signal sensed by the TCR of the lymphocyte to trigger its activation. Thus, it becomes a very attractive receptor to determine the fate of the immune response in different contexts from tolerance induction to immune activation. We discuss CD3-TCR complex assembly and the current and emerging approaches to harvest CD3 activity for immunotherapy. Harnessing the immune system to fight cancer has become a reality with the clinical success of immune-checkpoint blockade (ICB) antibodies against PD(L)-1 and CTLA-4. However, not all cancer patients respond to ICB. Thus, there is a need to modulate the immune system through alternative strategies for improving clinical responses to ICB. The CD3-T cell receptor (TCR) is the canonical receptor complex on T cells. It provides the first signal that initiates T cell activation and determines the specificity of the immune response. The TCR confers the binding specificity whilst the CD3 subunits facilitate signal transduction necessary for T cell activation. While the mechanisms through which antigen sensing and signal transduction occur in the CD3-TCR complex are still under debate, recent revelations regarding the intricate 3D structure of the CD3-TCR complex might open the possibility of modulating its activity by designing targeted drugs and tools, including aptamers. In this review, we summarize the basis of CD3-TCR complex assembly and survey the clinical and preclinical therapeutic tools available to modulate CD3-TCR function for potentiating cancer immunotherapy.
Published: 2023

9. Heterogeneity of Cholangiocarcinoma immune biology

Author: Vita, F. (Francesca), Olaizola, I. (Irene), Amato, F. (Francesco), Rae, C. (Colin), Marco, S. (Sergi), Banales, J.M. (Jesús M.), and Braconi, C. (Chiara)
Subjects: Cancer stem cells, Immune cells, Advanced biliary cancer, Dendritic cells, Cholangiocarcinoma, Matrix metalloproteinases, Liver, Tumor microenvironment, Hepatic stellate cells, Mesenchymal transition, Hepatocellular-carcinoma, Heterogeneity, Cancer-associated fibroblasts, Neutrophil-lymphocyte ratio, Intrahepatic cholangiocarcinoma
Abstract: Cholangiocarcinomas (CCAs) are aggressive tumors arising along the biliary tract epithelium, whose incidence and mortality are increasing. CCAs are highly desmoplastic cancers characterized by a dense tumor microenvironment (TME), in which each single component plays a fundamental role in shaping CCA initiation, progression and resistance to therapies. The crosstalk between cancer cells and TME can affect the recruitment, infiltration and differentiation of immune cells. According to the stage of the disease and to intra- and inter-patient heterogeneity, TME may contribute to either protumoral or antitumoral activities. Therefore, a better understanding of the effect of each immune cell subtype may open the path to new personalized immune therapeutic strategies for the management of CCA. In this review, we describe the role of immune cells in CCA initiation and progression, and their crosstalk with both cancer-associated fibroblasts (CAFs) and the cancer-stem-cell-like (CSC) niche.
Published: 2023

10. Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey: Results from an international survey

Author: Cobianchi, L. (Lorenzo), Dal Mas, F. (Francesca), Agnoletti, V. (Vanni), Ansaloni, L. (Luca), Biffl, W. (Walter), Butturini, G. (Giovanni), Campostrini, S. (Stefano), Catena, F. (Fausto), Denicolai, S. (Stefano), Fugazzola, P. (Paola), Martellucci, J. (Jacopo), Massaro, M. (Maurizio), Previtali, P. (Pietro), Ruta, F. (Federico), Venturi, A. (Alessandro), Woltz, S. (Sarah), Kaafarani, Haytham M., Loftus, Tyler J., Mascagni, P. (Pietro), Rodriguez Luna, M. (Maria Rita) R. (Rita), and Seeliger, B. (Barbara)
Subjects: Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Abstract: BACKGROUND: Shared decision-making (SDM) between clinicians and patients is one of the pillars of the modern patient-centric philosophy of care. This study aims to explore SDM in the discipline of trauma and emergency surgery, investigating its interpretation as well as the barriers and facilitators for its implementation among surgeons. METHODS: Grounding on the literature on the topics of the understanding, barriers, and facilitators of SDM in trauma and emergency surgery, a survey was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was sent to all 917 WSES members, advertised through the society's website, and shared on the society's Twitter profile. RESULTS: A total of 650 trauma and emergency surgeons from 71 countries in five continents participated in the initiative. Less than half of the surgeons understood SDM, and 30% still saw the value in exclusively engaging multidisciplinary provider teams without involving the patient. Several barriers to effectively partnering with the patient in the decision-making process were identified, such as the lack of time and the need to concentrate on making medical teams work smoothly. DISCUSSION: Our investigation underlines how only a minority of trauma and emergency surgeons understand SDM, and perhaps, the value of SDM is not fully accepted in trauma and emergency situations. The inclusion of SDM practices in clinical guidelines may represent the most feasible and advocated solutions.
Published: 2023

11. On the Hunt for Next-Generation Antimicrobial Agents:An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9–10 December 2021

Author: Antraygues, K. (Kevin), Compagne, N. (Nina), Ruggieri, F. (Francesca), Djaout, K. (Kamel), Edoo, Z. (Zainab), Eveque, M. (Maxime), Faïon, L. (Léo), Gioia, B. (Bruna), Tangara, S. (Salia), Vieira Da Cruz, A. (Anais), Villemagne, B. (Baptiste), Flipo, M. (Marion), Baulard, A. (Alain), willand, N. (nicolas), Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 [M2SV], and Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Abstract: The restrictions posed by the COVID-19 pandemic obliged the French Society for Medicinal Chemistry (Société de chimie thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) to organize their joint autumn symposium (entitled “On the hunt for next-generation antimicrobial agents”) online on 9–10 December 2021. The meeting attracted more than 200 researchers from France and abroad with interests in drug discovery, antimicrobial resistance, medicinal chemistry, and related disciplines. This review summarizes the 13 invited keynote lectures. The symposium generated high-level scientific dialogue on the most recent advances in combating antimicrobial resistance. The University of Lille, the Institut Pasteur de Lille, the journal Pharmaceuticals, Oxeltis, and INCATE, sponsored the event. 15 4
Published: 2022

12. Occupational complexity and cognition in the FINGER multidomain intervention trial

Author: Rydström, A. (Anders), Darin-Mattsson, A. (Alexander), Kåreholt, I. (Ingemar), Ngandu, T. (Tiia), Lehtisalo, J. (Jenni), Solomon, A. (Alina), Antikainen, R. (Riitta), Bäckman, L. (Lars), Hänninen, T. (Tuomo), Laatikainen, T. (Tiina), Levälahti, E. (Esko), Lindström, J. (Jaana), Paajanen, T. (Teemu), Havulinna, S. (Satu), Peltonen, M. (Markku), Sindi, S. (Shireen), Soininen, H. (Hilkka), Neely, A. S. (Anna Stigsdotter), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Kivipelto, M. (Miia), Mangialasche, F. (Francesca), Rydström, A. (Anders), Darin-Mattsson, A. (Alexander), Kåreholt, I. (Ingemar), Ngandu, T. (Tiia), Lehtisalo, J. (Jenni), Solomon, A. (Alina), Antikainen, R. (Riitta), Bäckman, L. (Lars), Hänninen, T. (Tuomo), Laatikainen, T. (Tiina), Levälahti, E. (Esko), Lindström, J. (Jaana), Paajanen, T. (Teemu), Havulinna, S. (Satu), Peltonen, M. (Markku), Sindi, S. (Shireen), Soininen, H. (Hilkka), Neely, A. S. (Anna Stigsdotter), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Kivipelto, M. (Miia), and Mangialasche, F. (Francesca)
Abstract: Introduction: Lifetime exposure to occupational complexity is linked to late-life cognition, and may affect benefits of preventive interventions. Methods: In the 2-year multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated, through post hoc analyses (N = 1026), the association of occupational complexity with cognition. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Results: Higher levels of occupational complexity were associated with better baseline cognition. Measures of occupational complexity had no association with intervention effects on cognition, except for occupational complexity with data, which was associated with the degree of intervention-related gains for executive function. Discussion: In older adults at increased risk for dementia, higher occupational complexity is associated with better cognition. The cognitive benefit of the FINGER intervention did not vary significantly among participants with different levels of occupational complexity. These exploratory findings require further testing in larger studies.
Published: 2022

13. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19:a three-stage modelling study

Author: Wu, Y. (Yao), Li, S. (Shanshan), Zhao, Q. (Qi), Wen, B. (Bo), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), Iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), De'Donato, F. (Francesca), Rao, S. (Shilpa), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), Zanotti Stagliorio Coelho, M. d. (Micheline de Sousa), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Nascimento Saldiva, P. H. (Paulo Hilario), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), Guo, Y. (Yuming), Wu, Y. (Yao), Li, S. (Shanshan), Zhao, Q. (Qi), Wen, B. (Bo), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), Iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), De'Donato, F. (Francesca), Rao, S. (Shilpa), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), Zanotti Stagliorio Coelho, M. d. (Micheline de Sousa), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Nascimento Saldiva, P. H. (Paulo Hilario), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), and Guo, Y. (Yuming)
Abstract: Background: Increased mortality risk is associated with short-term temperature variability: However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° degrees from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1753392 deaths (95% CI 1159 901–2357 718) were associated with temperature variability per year, ac
Published: 2022

14. Intervention services for autistic adults:an ASDEU study of autistic adults, carers, and professionals’ experiences

Author: Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Roge, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leosdottir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Celia), Budisteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia Garcia), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), Scattoni, M. L. (Maria Luisa), Schendel, D. (Diana), Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Roge, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leosdottir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Celia), Budisteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia Garcia), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), Scattoni, M. L. (Maria Luisa), and Schendel, D. (Diana)
Abstract: The Autism Spectrum Disorders in the European Union (ASDEU) survey investigated local services’ use experiences of autistic adults, carers and professionals with interventions for autistic adults. The majority of the 697 participants experienced recommended considerations prior to deciding on intervention and during the intervention plan and implementation. Psychosocial interventions were the most commonly experienced interventions, while pharmacological interventions NOT recommended for core autistic symptoms were reported by fairly large proportions of participants. Family interventions were experienced slightly more commonly by carers than adults or professionals. Less than the 26% of autistic adult responders who had experienced challenging behaviors reported receiving an intervention to change them. These results provide insights for improving gaps in service provision of interventions among autistic adults.
Published: 2022

15. LongITools:dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author: Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), and Sebert, S. (Sylvain)
Abstract: The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.
Published: 2022

16. The isolated Erebia pandrose Apennine population is genetically unique and endangered by climate change

Author: Sistri, G. (Ginevra), Menchetti, M. (Mattia), Santini, L. (Luca), Pasquali, L. (Lorenzo), Sapienti, S. (Sofia), Cini, A. (Alessandro), Platania, L. (Leonardo), Balletto, E. (Emilio), Barbero, F. (Francesca), Bonelli, S. (Simona), Casacci, L. P. (Luca Pietro), Dincă, V. (Vlad), Vila, R. (Roger), Mantoni, C. (Cristina), Fattorini, S. (Simone), Dapporto, L. (Leonardo), Sistri, G. (Ginevra), Menchetti, M. (Mattia), Santini, L. (Luca), Pasquali, L. (Lorenzo), Sapienti, S. (Sofia), Cini, A. (Alessandro), Platania, L. (Leonardo), Balletto, E. (Emilio), Barbero, F. (Francesca), Bonelli, S. (Simona), Casacci, L. P. (Luca Pietro), Dincă, V. (Vlad), Vila, R. (Roger), Mantoni, C. (Cristina), Fattorini, S. (Simone), and Dapporto, L. (Leonardo)
Abstract: 1. Climate change is causing shifts in the distribution of many species and populations inhabiting mountain tops are particularly vulnerable to these threats because they are constrained in altitudinal shifts. Apennines are a relatively narrow and low mountain chain located in Southern Europe, which hosts many isolated populations of mountain species. The butterfly Erebia pandrose was recorded for the last time in the Apennines in 1977, on the top of a single massif (Monti della Laga). 2. We confirmed the presence of a small, isolated population of E. pandrose in the Apennines, at a distance of more than 400 km to any other known populations. Then, we examined the cytochrome c oxidase subunit 1 mitochondrial DNA marker of this species across the Palaearctic area and estimated the potential decline over the Alps and the Apennines due to future climatic changes. 3. The Apennine population represents an endemic lineage characterised by eight mutations over the 658 bp analysed (1.2%). In the Alps and Apennines, this species has shifted uphill more than 3 m per year since the end of the 19th century and more than 22 m per year since 1995. Species distribution models suggested that these mountain populations will experience a generalised loss of climatic suitability, which, according to our projections, could lead to the extinction of the Apennine population in a few decades. 4. Erebia pandrose has the potential to become a flagship species for advertising the risk of losing unique fractions of genetic diversity for mountain species.
Published: 2022

17. Preface

Author: Spezzano, F. (Francesca), Amaral, A. (Adriana), Ceolin, D. (Davide), Fazio, L. (Lisa), Serra, E. (Edoardo), Spezzano, F. (Francesca), Amaral, A. (Adriana), Ceolin, D. (Davide), Fazio, L. (Lisa), and Serra, E. (Edoardo)
Published: 2022

18. Preface

Author: Symeonidou, D. (Danai), Yu, R. (Ran), Ceolin, D. (Davide), Poveda, M. (María), Audrito, D. (Davide), Di Caro, L. (Luigi), Grasso, F. (Francesca), Nai, R. (Roberto), Sulis, E. (Emilio), Ekaputra, F.J. (Fajar), Kutz, O. (Oliver), Troquard, N. (Nicolas), Poveda-Villálon, M. (María), Dsouza, A. (Alishiba), Roussey, C. (Catherine), Cheng, G. (Gong), Galarraga, L. (Luis), Pernelle, N. (Nathalie), Tempelmeier, N. (Nicolas), Dietze, S. (Sefan), Gottschalk, S. (Simon), Adebayo, K. (Kolawole), Basile, V. (Valerio), Boella, G. (Guido), Esteves, B. (Beatriz), Ferrara, A. (Alfio), Montanelli, S. (Stefano), Nanda, R. (Rohan), Navas Loro, M. (María), Palmirani, M. (Monica), Pandit, H.J. (Harshvardhan), Robaldo, L. (Livio), Rodríguez-Doncel, V. (Víctor), Sapienza, S. (Salvatore), Sartor, G. (Galileo), Siragusa, G. (Giovanni), Tagarelli, A. (Andrea), Symeonidou, D. (Danai), Yu, R. (Ran), Ceolin, D. (Davide), Poveda, M. (María), Audrito, D. (Davide), Di Caro, L. (Luigi), Grasso, F. (Francesca), Nai, R. (Roberto), Sulis, E. (Emilio), Ekaputra, F.J. (Fajar), Kutz, O. (Oliver), Troquard, N. (Nicolas), Poveda-Villálon, M. (María), Dsouza, A. (Alishiba), Roussey, C. (Catherine), Cheng, G. (Gong), Galarraga, L. (Luis), Pernelle, N. (Nathalie), Tempelmeier, N. (Nicolas), Dietze, S. (Sefan), Gottschalk, S. (Simon), Adebayo, K. (Kolawole), Basile, V. (Valerio), Boella, G. (Guido), Esteves, B. (Beatriz), Ferrara, A. (Alfio), Montanelli, S. (Stefano), Nanda, R. (Rohan), Navas Loro, M. (María), Palmirani, M. (Monica), Pandit, H.J. (Harshvardhan), Robaldo, L. (Livio), Rodríguez-Doncel, V. (Víctor), Sapienza, S. (Salvatore), Sartor, G. (Galileo), Siragusa, G. (Giovanni), and Tagarelli, A. (Andrea)
Published: 2022

19. Chest CT-assessed comorbidities and all-cause mortality risk in COPD patients in the BODE cohort

Author: Ezponda, A. (Ana), Casanova, C. (Ciro), Divo, M. (Miguel), Marín-Oto, M. (Marta), Marin, J.M. (José M.), Bastarrika, G. (Gorka), Pinto-Plata, V. (Víctor), Martin-Palmero, A. (Ángela), Polverino, F. (Francesca), Celli, B.R. (Bartolomé R.), and Torres, J.P. (Juan P.) de
Subjects: Chest CT, COPD, Comorbidity, All-cause mortality, Tomography
Abstract: Background and objective: The availability of chest computed tomography (CT) imaging can help diagnose comorbidities associated with chronic obstructive pulmonary disease (COPD). Their systematic identification and relationship with allcause mortality have not been explored. Furthermore, whether their CT-detected prevalence differs from clinical diagnosis is unknown. Methods: The prevalence of 10 CT-assessed comorbidities was retrospectively determined at baseline in 379 patients (71% men) with mild to severe COPD attending pulmonary clinics. Anthropometrics, smoking history, dyspnoea, lung function, exercise capacity, BODE (BMI, Obstruction, Dyspnoea and Exercise capacity) index and exacerbations rate were recorded. The prevalence of CT-determined comorbidities was compared with that recorded clinically. Over a median of 78 months of observation, the independent association with all-cause mortality was analysed. A ‘CT-comorbidome’ graphically expressed the strength of their association with mortality risk. Results: Coronary artery calcification, emphysema and bronchiectasis were the most prevalent comorbidities (79.8%, 62.7% and 33.9%, respectively). All were underdiagnosed before CT. Coronary artery calcium (hazard ratio [HR] 2.09; 95% CI 1.03–4.26, p = 0.042), bronchiectasis (HR 2.12; 95% CI 1.05–4.26, p = 0.036) and low psoas muscle density (HR 2.61; 95% CI 1.23–5.57, p = 0.010) were independently associated with all-cause mortality and helped define the ‘CT-comorbidome’. Conclusion: This study of COPD patients shows that systematic detection of 10 CT-diagnosed comorbidities, most of which were not detected clinically, provides information of potential use to patients and clinicians caring for them.
Published: 2022

20. Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats

Author: Verhaeghe, R. (Remy), Gao, V. (Vance), MORLEY-FLETCHER, S. (Sara), Bouwalerh, H. (Hammou), Van Camp, G. (Gilles), Cisani, F. (Francesca), Nicoletti, F. (Ferdinando), Maccari, S. (Stefania), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], and Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Subjects: Early life stress, Sex differences, Brain aging, Behaviors, Hormones
Abstract: Brain aging may be programmed by early-life stress. Aging affects males and females differently, but how perinatal stress (PRS) affects brain aging between sexes is unknown. We showed behavioral and neurobiological sex differences in non-stressed control rats that were strongly reduced or inverted in PRS rats. In particular, PRS decreased risk-taking behavior, spatial memory, exploratory behavior, and fine motor behavior in male aged rats. In contrast, female aged PRS rats displayed only increased risk-taking behavior and reduced exploratory behavior. PRS induced large reductions in the expression of glutamate receptors in the ventral and dorsal hippocampus and prefrontal cortex only in male rats. PRS also reduced the expression of synaptic vesicle-associated proteins, glucocorticoid receptors (GR), and mineralocorticoid receptors (MR) in the ventral hippocampus of aged male rats. In contrast, in female aged rats, PRS enhanced the expression of MRs and brain-derived neurotrophic factor (BDNF) in the ventral hippocampus and the expression of glial fibrillary acidic protein (GFAP) and BDNF in the prefrontal cortex. A common PRS effect in both sexes was a reduction in exploratory behavior and metabotropic glutamate (mGlu2/3) receptors in the ventral hippocampus and prefrontal cortex. A multidimensional analysis revealed that PRS induced a demasculinization profile in glutamate-related proteins in the ventral and dorsal hippocampus and prefrontal cortex, as well as a demasculinization profile of stress markers only in the dorsal hippocampus. In contrast, defeminization was observed only in the ventral hippocampus. Measurements of testosterone and 17-β-estradiol in the plasma and aromatase in the dorsal hippocampus were consistent with a demasculinizing action of PRS. These findings confirm that the brains of males and females differentially respond to PRS and aging suggesting that females might be more protected against early stress and age-related inflammation and neurodegeneration. Taken together, these results may contribute to understanding how early environmental factors shape vulnerability to brain aging in both sexes and may lay the groundwork for future studies aimed at identifying new treatment strategies to improve the quality of life of older individuals, which is of particular interest given that there is a high growth of aging in populations around the world.
Published: 2021

21. Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease

Author: López, B. (Beatriz), Alvarez-Erviti, L. (Lydia), De-Santis, B. (Barbara), Izco, M. (María), López-Calvo, S. (Silvia), Marzo-Sola, M.E. (María Eugenia), Debegnach, F. (Francesca), Lizarraga, E. (Elena), Lopez-de-Cerain, A. (Adela), Gonzalez-Peñas, E. (Elena), and Vettorazzi, A. (Ariane)
Subjects: Sterigmatocystin, Parkinson's disease, Ochratoxin A, Mycotoxins, Alzheimer's disease, Human exposure, Neurodegenerative disease
Abstract: Exposure to environmental contaminants might play an important role in neurodegenerative disease pathogenesis, such as Parkinson ' s disease (PD) and Alzheimer's disease (AD). For the first time in Spain, the plasmatic levels of 19 mycotoxins from patients diagnosed with a neurodegenerative disease (44 PD and 24 AD) and from their healthy companions (25) from La Rioja region were analyzed. The studied mycotoxins were aflatoxins B1, B2, G1, G2 and M1, T-2 and HT-2, ochratoxins A (OTA) and B (OTB), zearalenone, sterigmatocystin (STER), nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxy-deoxynivalenol, neosolaniol, diacetoxyscirpenol and fusarenon-X. Samples were analyzed by LC-MS/MS before and after treatment with beta-glucuronidase/arylsulfatase in order to detect potential metabolites. Only OTA, OTB and STER were detected in the samples. OTA was present before (77% of the samples) and after (89%) the enzymatic treatment, while OTB was only detectable before (13%). Statistically significant differences in OTA between healthy companions and patients were observed but the observed differences might seem more related to gender (OTA levels higher in men, p-value = 0.0014) than the disease itself. STER appeared only after enzymatic treatment (88%). Statistical analysis on STER, showed distributions always different between healthy controls and patients (patients' group > controls, p-value < 0.0001). Surprisingly, STER levels weakly correlated positively with age in women (rho = 0.3384), while OTA correlation showed a decrease of levels with age especially in the men with PD (rho = -0.4643).
Published: 2021

22. The GenTree Leaf Collection:inter‐ and intraspecific leaf variation in seven forest tree species in Europe

Author: Benavides, R. (Raquel), Carvalho, B. (Barbara), Bastias, C. C. (Cristina C.), Lopez-Quiroga, D. (David), Mas, A. (Antonio), Cavers, S. (Stephen), Gray, A. (Alan), Albet, A. (Audrey), Alia, R. (Ricardo), Ambrosio, O. (Olivier), Aravanopoulos, F. (Filippos), Aunon, F. (Francisco), Avanzi, C. (Camilla), Avramidou, E. V. (Evangelia V.), Bagnoli, F. (Francesca), Ballesteros, E. (Eduardo), Barbas, E. (Evangelos), Bastien, C. (Catherine), Bernier, F. (Frederic), Bignalet, H. (Henry), Bouic, D. (Damien), Brunetto, W. (William), Buchovska, J. (Jurata), Cabanillas-Saldana, A. M. (Ana M.), Cheval, N. (Nicolas), Climent, J. M. (Jose M.), Correard, M. (Marianne), Cremer, E. (Eva), Danusevicius, D. (Darius), Dauphin, B. (Benjamin), Del Cano, F. (Fernando), Denou, J.-L. (Jean-Luc), Dokhelar, B. (Bernard), Dourthe, R. (Remi), Farsakoglou, A.-M. (Anna-Maria), Fera, A. (Andreas), Fonti, P. (Patrick), Ganopoulos, I. (Ioannis), Garcia del Barrio, J. M. (Jose M.), Gilg, O. (Olivier), Gonzalez-Martinez, S. C. (Santiago C.), Graf, R. (Rene), Grivet, D. (Delphine), Gugerli, F. (Felix), Hartleitner, C. (Christoph), Heer, K. (Katrin), Hollenbach, E. (Enja), Hurel, A. (Agathe), Issehuth, B. (Bernard), Jean, F. (Florence), Jorge, V. (Veronique), Jouineau, A. (Arnaud), Kappner, J.-P. (Jan-Philipp), Kärkkainen, K. (Katri), Kesälahti, R. (Robert), Knutzen, F. (Florian), Kujala, S. T. (Sonja T.), Kumpula, T. (Timo), Labriola, M. (Mariaceleste), Lalanne, C. (Celine), Lambertz, J. (Johannes), Lascoux, M. (Martin), Le Provost, G. (Gregoire), Liesebach, M. (Mirko), Malliarou, E. (Ermioni), Marchon, J. (Jeremy), Mariotte, N. (Nicolas), Martinez-Sancho, E. (Elisabet), Matesanz, S. (Silvia), Meischner, H. (Helge), Michotey, C. (Celia), Milesi, P. (Pascal), Morganti, S. (Sandro), Myking, T. (Tor), Nilsen, A. E. (Anne E.), Notivol, E. (Eduardo), Opgenoorth, L. (Lars), ostreng, G. (Geir), Pakull, B. (Birte), Piotti, A. (Andrea), Plomion, C. (Christophe), Poinot, N. (Nicolas), Pringarbe, M. (Mehdi), Puzos, L. (Luc), Pyhajarvi, T. (Tanja), Raffin, A. (Annie), Ramirez-Valiente, J. A. (Jose A.), Rellstab, C. (Christian), Richter, S. (Sebastian), Robledo-Arnuncio, J. J. (Juan J.), San Segundo, S. (Sergio), Savolainen, O. (Outi), Schneck, V. (Volker), Schueler, S. (Silvio), Scotti, I. (Ivan), Semerikov, V. (Vladimir), Henrik Sonstebo, J. (Jorn), Spanu, I. (Ilaria), Thevenet, J. (Jean), Tollefsrud, M. M. (Mari Mette), Turion, N. (Norbert), Vendramin, G. G. (Giovanni Giuseppe), Villar, M. (Marc), Westin, J. (Johan), Fady, B. (Bruno), and Valladares, F. (Fernando)
Subjects: tree species, leaf economics spectrum, leaf functional traits, phenotypic variation, intraspecific variability, European forests
Abstract: Motivation: Trait variation within species can reveal plastic and/or genetic responses to environmental gradients, and may indicate where local adaptation has occurred. Here, we present a dataset of rangewide variation in leaf traits from seven of the most ecologically and economically important tree species in Europe. Sample collection and trait assessment are embedded in the GenTree project (EU‐Horizon 2020), which aims at characterizing the genetic and phenotypic variability of forest tree species to optimize the management and sustainable use of forest genetic resources. Our dataset captures substantial intra‐ and interspecific leaf phenotypic variability, and provides valuable information for studying the relationship between ecosystem functioning and trait variability of individuals, and the response and resilience of species to environmental changes. Main types of variable contained: We chose morphological and chemical characters linked to trade‐offs between acquisition and conservation of resources and water use, namely specific leaf area, leaf size, carbon and nitrogen content and their ratio, and the isotopic signature of stable isotope ¹³C and ¹⁵N in leaves. Spatial location and grain: We surveyed between 18 and 22 populations per species, 141 in total, across Europe. Time period: Leaf sampling took place between 2016 and 2017. Major taxa and level of measurement: We sampled at least 25 individuals in each population, 3,569 trees in total, and measured traits in 35,755 leaves from seven European tree species, i.e. the conifers Picea abies, Pinus pinaster and Pinus sylvestris, and the broadleaves Betula pendula, Fagus sylvatica, Populus nigra and Quercus petraea. Software format: The data files are in ASCII text, tab delimited, not compressed.
Published: 2021

23. The GenTree Platform:growth traits and tree-level environmental data in 12 European forest tree species

Author: Opgenoorth, L. (Lars), Benjamin, D. (Dauphin), Benavides, R. (Raquel), Heer, K. (Katrin), Alizoti, P. (Paraskevi), Martinez-Sancho, E. (Elisabet), Alia, R. (Ricardo), Ambrosio, O. (Olivier), Audrey, A. (Albet), Aunon, F. (Francisco), Avanzi, C. (Camilla), Avramidou, E. (Evangelia), Bagnoli, F. (Francesca), Barbas, E. (Evangelos), Bastias, C. C. (Cristina C.), Bastien, C. (Catherine), Ballesteros, E. (Eduardo), Beffa, G. (Giorgia), Bernier, F. (Frederic), Bignalet, H. (Henri), Bodineau, G. (Guillaume), Bouic, D. (Damien), Brodbeck, S. (Sabine), Brunetto, W. (William), Buchovska, J. (Jurata), Buy, M. (Melanie), Cabanillas-Saldana, A. M. (Ana M.), Carvalho, B. (Barbara), Cheval, N. (Nicolas), Climent, J. M. (Jose M.), Correard, M. (Marianne), Cremer, E. (Eva), Danusevicius, D. (Darius), Del Cano, F. (Fernando), Denou, J.-L. (Jean-Luc), di Gerardi, N. (Nicolas), Dokhelar, B. (Bernard), Ducousso, A. (Alexis), Nilsen, A. E. (Anne Eskild), Farsakoglou, A.-M. (Anna-Maria), Fonti, P. (Patrick), Ganopoulos, I. (Ioannis), Garcia del Barrio, J. M. (Jose M.), Gilg, O. (Olivier), Gonzalez-Martinez, S. C. (Santiago C.), Graf, R. (Rene), Gray, A. (Alan), Grivet, D. (Delphine), Gugerli, F. (Felix), Hartleitner, C. (Christoph), Hollenbach, E. (Enja), Hurel, A. (Agathe), Issehut, B. (Bernard), Jean, F. (Florence), Jorge, V. (Veronique), Jouineau, A. (Arnaud), Kappner, J.-P. (Jan-Philipp), Karkkainen, K. (Katri), Kesälahti, R. (Robert), Knutzen, F. (Florian), Kujala, S. T. (Sonja T.), Kumpula, T. A. (Timo A.), Labriola, M. (Mariaceleste), Lalanne, C. (Celine), Lambertz, J. (Johannes), Lascoux, M. (Martin), Lejeune, V. (Vincent), Le-Provost, G. (Gregoire), Levillain, J. (Joseph), Liesebach, M. (Mirko), Lopez-Quiroga, D. (David), Meier, B. (Benjamin), Malliarou, E. (Ermioni), Marchon, J. (Jeremy), Mariotte, N. (Nicolas), Mas, A. (Antonio), Matesanz, S. (Silvia), Meischner, H. (Helge), Michotey, C. (Celia), Milesi, P. (Pascal), Morganti, S. (Sandro), Nievergelt, D. (Daniel), Notivol, E. (Eduardo), Ostreng, G. (Geir), Pakull, B. (Birte), Perry, A. (Annika), Piotti, A. (Andrea), Plomion, C. (Christophe), Poinot, N. (Nicolas), Pringarbe, M. (Mehdi), Puzos, L. (Luc), Pyhajarvi, T. (Tanja), Raffin, A. (Annie), Ramirez-Valiente, J. A. (Jose A.), Rellstab, C. (Christian), Remi, D. (Dourthe), Richter, S. (Sebastian), Robledo-Arnuncio, J. J. (Juan J.), San Segundo, S. (Sergio), Savolainen, O. (Outi), Schueler, S. (Silvio), Schneck, V. (Volker), Scotti, I. (Ivan), Semerikov, V. (Vladimir), Slamova, L. (Lenka), Sonstebo, J. H. (Jorn Henrik), Spanu, I. (Ilaria), Thevenet, J. (Jean), Tollefsrud, M. M. (Mari Mette), Turion, N. (Norbert), Vendramin, G. G. (Giovanni Giuseppe), Villar, M. (Marc), von Arx, G. (Georg), Westin, J. (Johan), Fady, B. (Bruno), Myking, T. (Tor), Valladares, F. (Fernando), Aravanopoulos, F. A. (Filippos A.), and Cavers, S. (Stephen)
Subjects: crown size, fruit number, bark thickness, DBH, regeneration, branch angle, soil depth, forking index, stem straightness, height
Abstract: Background: Progress in the field of evolutionary forest ecology has been hampered by the huge challenge of phenotyping trees across their ranges in their natural environments, and the limitation in high-resolution environmental information. Findings: The GenTree Platform contains phenotypic and environmental data from 4,959 trees from 12 ecologically and economically important European forest tree species: Abies alba Mill. (silver fir), Betula pendula Roth. (silver birch), Fagus sylvatica L. (European beech), Picea abies (L.) H. Karst (Norway spruce), Pinus cembra L. (Swiss stone pine), Pinus halepensis Mill. (Aleppo pine), Pinus nigra Arnold (European black pine), Pinus pinaster Aiton (maritime pine), Pinus sylvestris L. (Scots pine), Populus nigra L. (European black poplar), Taxus baccata L. (English yew), and Quercus petraea (Matt.) Liebl. (sessile oak). Phenotypic (height, diameter at breast height, crown size, bark thickness, biomass, straightness, forking, branch angle, fructification), regeneration, environmental in situ measurements (soil depth, vegetation cover, competition indices), and environmental modeling data extracted by using bilinear interpolation accounting for surrounding conditions of each tree (precipitation, temperature, insolation, drought indices) were obtained from trees in 194 sites covering the species’ geographic ranges and reflecting local environmental gradients. Conclusions: The GenTree Platform is a new resource for investigating ecological and evolutionary processes in forest trees. The coherent phenotyping and environmental characterization across 12 species in their European ranges allow for a wide range of analyses from forest ecologists, conservationists, and macro-ecologists. Also, the data here presented can be linked to the GenTree Dendroecological collection, the GenTree Leaf Trait collection, and the GenTree Genomic collection presented elsewhere, which together build the largest evolutionary forest ecology data collection available.
Published: 2021

24. Smoking status during first-line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study

Author: Cortellini, A. (Alessio), De Giglio, A. (Andrea), Cannita, K. (Katia), Cortinovis, D.L. (Diego L.), Cornelissen, R. (Robin), Baldesarri, C. (Cinzia), Giusti, R. (Raffaele), D'Argento, E. (Ettore), Grossi, F. (Francesco), Santoni, M. (Matteo), Catino, A. (Annamaria), Berardi, R. (Rossana), Sforza, V. (Vincenzo), Rossi, G. (Giovanni), Antonuzzo, L. (Lorenzo), Di Noia, V. (Vincenzo), Signorelli, D. (Diego), Gelibter, A. (Alain), Occhipinti, M.A. (Mario Alberto), Follador, A. (Alessandro), Rastelli, F. (Francesca), Chiari, R. (Rita), Gravara, L.D. (Luigi Della), Inno, A. (Alessandro), De Tursi, M. (Michele), Di Marino, P. (Pietro), Mansueto, G. (Giovanni), Zoratto, F. (Federica), Filetti, M. (Marco), Montrone, M. (Michele), Citarella, F. (Fabrizio), Pensieri, M.V. (Maria Vittoria), Russano, M. (Marco), Cantini, L. (Luca), Nigro, O. (Olga), Leonetti, A. (Alessandro), Bordi, P. (Paola), Minuti, G. (Gabriele), Landi, L. (Lorenza), De Toma, A. (Alessandro), Donisi, C. (Clelia), Ricciardi, S. (Serena), Migliorino, M.R. (Maria Rita), Napoli, V.M. (Valerio Maria), Leone, G. (Gianmarco), Metro, G. (Giulio), Banna, G.L. (Giuseppe L.), Friedlaender, A. (Alex), Addeo, A. (Alfredo), Ficorella, C. (Corrado), Porzio, G. (Giampiero), Cortellini, A. (Alessio), De Giglio, A. (Andrea), Cannita, K. (Katia), Cortinovis, D.L. (Diego L.), Cornelissen, R. (Robin), Baldesarri, C. (Cinzia), Giusti, R. (Raffaele), D'Argento, E. (Ettore), Grossi, F. (Francesco), Santoni, M. (Matteo), Catino, A. (Annamaria), Berardi, R. (Rossana), Sforza, V. (Vincenzo), Rossi, G. (Giovanni), Antonuzzo, L. (Lorenzo), Di Noia, V. (Vincenzo), Signorelli, D. (Diego), Gelibter, A. (Alain), Occhipinti, M.A. (Mario Alberto), Follador, A. (Alessandro), Rastelli, F. (Francesca), Chiari, R. (Rita), Gravara, L.D. (Luigi Della), Inno, A. (Alessandro), De Tursi, M. (Michele), Di Marino, P. (Pietro), Mansueto, G. (Giovanni), Zoratto, F. (Federica), Filetti, M. (Marco), Montrone, M. (Michele), Citarella, F. (Fabrizio), Pensieri, M.V. (Maria Vittoria), Russano, M. (Marco), Cantini, L. (Luca), Nigro, O. (Olga), Leonetti, A. (Alessandro), Bordi, P. (Paola), Minuti, G. (Gabriele), Landi, L. (Lorenza), De Toma, A. (Alessandro), Donisi, C. (Clelia), Ricciardi, S. (Serena), Migliorino, M.R. (Maria Rita), Napoli, V.M. (Valerio Maria), Leone, G. (Gianmarco), Metro, G. (Giulio), Banna, G.L. (Giuseppe L.), Friedlaender, A. (Alex), Addeo, A. (Alfredo), Ficorella, C. (Corrado), and Porzio, G. (Giampiero)
Abstract: Background: Improved outcome in tobacco smoking patients with non-small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first-line immunotherapy in patients with high PD-L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods: We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first-line pembrolizumab and platinum-based chemotherapy. Results: A total of 962 NSCLC patients with PD-L1 expression ≥50% who received first-line pembrolizumab and 462 NSCLC patients who received first-line platinum-based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression-free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking stat
Published: 2021
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25. Impact of baseline and newly acquired conduction disorders on need for permanent pacemakers with 3 consecutive generations of self-expanding transcatheter aortic heart valves

Author: Kroon, H.G. (Herbert G.), Gils, L. (Lennart) van, Ziviello, F. (Francesca), Wiechen, M.P. (Maarten) van, Ooms, J. (Joris), Rahhab, Z. (Zouhair), El Faquir, N. (Nahid), Maugenest, A.M., Kardys, I. (Isabella), Daemen, J. (Joost), Jaegere, P.P.T. (Peter) de, Mieghem, N.M. (Nicolas) van, Kroon, H.G. (Herbert G.), Gils, L. (Lennart) van, Ziviello, F. (Francesca), Wiechen, M.P. (Maarten) van, Ooms, J. (Joris), Rahhab, Z. (Zouhair), El Faquir, N. (Nahid), Maugenest, A.M., Kardys, I. (Isabella), Daemen, J. (Joost), Jaegere, P.P.T. (Peter) de, and Mieghem, N.M. (Nicolas) van
Abstract: Introductions: We aimed to compare conduction dynamics and need for permanent pacemaker implantation (PPI) after CoreValve, Evolut R and PRO (transcatheter aortic valve replacement (TAVR)). Methods: Patients were stratified based on conduction at baseline; Cohort A had normal conduction, Cohort B had conduction abnormalities including atrioventricular (AV)-block, fascicular block or complete bundle branch block. Three different dynamic QRS-patterns were defined: stable QRS-duration, transient QRS-prolongation and persistent QRS-prolongation. We performed multivariable regression analysis to estimate the effect of the three separate transcatheter heart valves (THV's) on need for PPI at 30 days. Results: TAVR was performed with CoreValve (N = 113), Evolut R (N = 157) or Evolut PRO (N = 92). Conduction dynamics were similar between the different THVs. Overall, Evolut R and PRO showed a tendency towards less PPI compared to CoreValve (17% vs. 19% vs. 27%, P = 0.08), which was driven by a lower PPI rate in Cohort A (6% vs. 11% vs. 25%, P = 0.002). Need for PPI was restricted to patients with persistent QRS-prolongation in Cohort A (26/106) but did not correlate with conduction dynamics in Cohort B. In multivariable logistic regression analysis the use of Evolut R (OR 0.38, 95% CI 0.19–0.78, P = 0.008) and PRO (OR 0.41, 95% CI 0.19–0.91, P-value = 0.028) were independently associated with less need for PPI. Conclusion: The newer generations Evolut R and PRO were associated with less PPI compared to CoreValve. Acquired persistent conduction abnormalities predicted PPI after TAVR only in patients with normal conduction at baseline. Our findings may help identify eligible patients for early discharge after Evolut R/PRO TAVR.
Published: 2021
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26. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Author: Coignard, J. (Juliette), Lush, M. (Michael), Beesley, J. (Jonathan), O’Mara, T.A. (Tracy A.), Dennis, J. (Joe), Tyrer, J.P. (Jonathan P.), Barnes, D. (Daniel), McGuffog, L. (Lesley), Leslie, G. (Goska), Bolla, M.K. (Manjeet K.), Adank, M.A. (Muriel), Agata, S. (Simona), Ahearn, T. (Thomas), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Augustinsson, A. (Annelie), Azzollini, J., Barrowdale, D. (Daniel), Baynes, C. (Caroline), Becher, H. (Heko), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Białkowska, K. (Katarzyna), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Borg, Å. (Åke), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campa, D. (Daniele), Carter, B.D. (Brian D.), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B. M.), Clarke, C.L. (Christine L.), Bertrand, O. (Ophélie), Caputo, S. (Sandrine), Dupré, A. (Anaïs), Le Mentec, M. (Marine), Belotti, M. (Muriel), Birot, A.-M. (Anne-Marie), Buecher, B. (Bruno), Fourme, E. (Emmanuelle), Gauthier-Villars, M. (Marion), Golmard, L. (Lisa), Houdayer, C. (Claude), Moncoutier, V. (Virginie), de Pauw, A. (Antoine), Saule, C. (Claire), Sinilnikova, O. (Olga), Mazoyer, S. (Sylvie), Damiola, F. (Francesca), Barjhoux, L. (Laure), Verny-Pierre, C. (Carole), Léone, M. (Mélanie), Boutry-Kryza, N. (N.), Calender, A. (Alain), Giraud, S. (Sophie), Caron, O. (Olivier), Guillaud-Bataille, M. (Marine), Bressac-de Paillerets, B. (Brigitte), Bignon, Y.-J. (Yves-Jean), Uhrhammer, N. (Nancy), Lasset, C. (Christine), Bonadona, V. (Valérie), Berthet, P. (Pascaline), Vaur, D. (Dominique), Castera, L. (Laurent), Noguchi, T. (Tetsuro), Popovici, C. (Cornel), Sobol, H. (Hagay), Bourdon, V. (Violaine), Remenieras, A. (Audrey), Nogues, C. (Catherine), Coupier, I. (Isabelle), Pujol, P. (Pascal), Dumont, A. (Aurélie), Révillion, F. (Françoise), Adenis, C. (Claude), Muller, D.W. (Danièle), Barouk-Simonet, E. (Emmanuelle), Bonnet, F. (Françoise), Bubien, V. (Virginie), Sevenet, N. (Nicolas), Longy, M. (Michel), Toulas, C. (Christine), Guimbaud, R. (Rosine), Gladieff, L. (Laurence), Feillel, V. (Viviane), Leroux, D. (Dominique), Dreyfus, H. (Hélène), Rebischung, C. (Christine), Peysselon, M. (Magalie), Coron, F. (Fanny), Faivre, L. (Laurence), Baurand, A. (Amandine), Jacquot, C. (Caroline), Bertolone, G. (Geoffrey), Lizard, S. (Sarab), Prieur, F. (Fabienne), Lebrun, M. (Marine), Kientz, C. (Caroline), Ferrer, S.F., Mari, V. (Véronique), Vénat-Bouvet, L. (Laurence), Delnatte, C. (Capucine), Bézieau, S. (Stéphane), Mortemousque, I. (Isabelle), Coulet, F. (Florence), Colas, C. (Chrystelle), Soubrier, F. (Florent), Warcoin, M. (Mathilde), Sokolowska, J. (Johanna), Bronner, M. (Myriam), Collonge-Rame, M.-A., Damette, A. (Alexandre), Gesta, P. (Paul), Lallaoui, H. (Hakima), Chiesa, J. (Jean), Molina-Gomes, D. (Denise), Ingster, O. (Olivier), Gregory, H. (Helen), Miedzybrodzka, Z. (Zosia), Morrison, P.J. (Patrick J.), Ong, K.-R. (Kai-ren), Donaldson, A. (Alan), Rogers, M.T. (Mark), Kennedy, M.J. (M. John), Porteous, M.E. (Mary), Brewer, C. (Carole), Davidson, R. (Rosemarie), Izatt, L. (Louise), Brady, A. (A.), Barwell, J. (Julian), Adlard, J.W. (Julian), Foo, C. (Claire), Lalloo, F. (Fiona), Side, L.E. (Lucy E.), Eason, J. (Jacqueline), Henderson, A. (Alex), Walker, L. (Lisa), Eeles, R. (Rosalind), Cook, J. (Jackie), Snape, K. (Katie), Eccles, D. (Diana), Murray, A. (Alexandra), McCann, E. (Emma), Collée, J.M. (J. Margriet), Conroy, D.M. (Don M.), Czene, K. (Kamila), Daly, M.B. (Mary B.), Devilee, P. (Peter), Diez, O. (Orland), Ding, Y.C. (Yuan Chun), Domchek, S.M. (Susan), Dörk, T. (Thilo), Santos Silva, I. (Isabel) dos, Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D.G. (D. Gareth), Fasching, P.A. (Peter), Flyger, H. (Henrik), Fostira, F. (Florentia), Friedman, E. (Eitan), Fritschi, L. (Lin), Frost, D. (Debra), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Garcia-Barberan, V. (Vanesa), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A.), Gaudet, M.M. (Mia M.), Gayther, S.A. (Simon), Gehrig, A. (Andrea), Georgoulias, V. (Vassilios), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Radice, P. (Paolo), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Guénel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), He, W. (Wei), Hogervorst, F.B.L. (Frans B. L.), Hollestelle, A. (Antoinette), Hopper, J.L. (John), Horcasitas, D.J. (Darling J.), Hulick, P.J. (Peter J.), Hunter, D.J. (David J.), Imyanitov, E.N. (Evgeny), Fox, S.B. (Stephen), Campbell, I. (Ian), Spurdle, A. (Amanda), Webb, P. (Penny), De Fazio, A. (Anna), Tassell, M. (Margaret), Kirk, J. (Judy), Lindeman, G.J. (Geoffrey), Price, M. (Melanie), Southey, M.C. (Melissa), Milne, R.L. (Roger), Deb, S. (Sid), Bowtell, D. (David), Hout, A.H. (Annemarie) van der, Ouweland, A.M.W. (Ans) van den, Mensenkamp, A.R. (Arjen R.), Deurzen, C.H.M. (Carolien) van, Kets, C.M. (Marleen), Seynaeve, C.M. (Caroline), van Asperen, C.J. (Christi J.), Aalfs, C.M. (Cora), Gómez Garcia, E.B. (Encarna B.), Leeuwen, F.E. (Flora) van, Bock, G.H. (Geertruida) de, Meijers-Heijboer, E.J. (Hanne), Obdeijn, A.I.M. (Inge-Marie), Gille, J.J.P. (J. J.P.), Oosterwijk, J.C. (Jan), Wijnen, J.T. (Juul), Kolk, L.E. (Lizet) van der, Hooning, M.J. (Maartje), Ausems, M.G.E.M. (Margreet), Mourits, M.J. (Marjan), Blok, M.J. (Marinus J.), Rookus, M.A. (Matti), van der Luijt, R.B. (Rob B.), Cronenburg, T.C.T.E.F. van, Pol, C. (Carmen) van der, Russell, N.S. (Nicola), Siesling, S. (Sabine), Overbeek, L.I.H. (Lucy), Wijnands, R. (R.), Lange, J.L. (J.) de, Clarke, C. (Christine), Graham, D. (Dinny), Sachchithananthan, M. (Mythily), Marsh, D. (Deborah), Scott, R.J. (Rodney), Baxter, R. (Robert), Yip, D. (Desmond), Carpenter, T.A. (Adrian), Davis, A. (Alison), Pathmanathan, N. (Nirmala), Simpson, P. (Peter), Jager, A. (Agnes), Jakubowska, A. (Anna), James, M. (Margaret), Jensen, U.B. (Uffe Birk), John, E.M. (Esther), Jones, M.E. (Michael E.), Kaaks, R. (Rudolf), Kapoor, P.M. (Pooja Middha), Karlan, B.Y. (Beth), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kiiski, J.I. (Johanna I.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kurian, A.W. (Allison W.), Laitman, Y. (Yael), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lester, J. (Jenny), Lesueur, F. (Fabienne), Lindstrom, T. (Tricia), Lopez-Fernández, A. (Adria), Loud, J.T. (Jennifer T.), Luccarini, C. (Craig), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J.W.M. (John), Mebirouk, N. (Noura), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger L.), Montagna, M. (Marco), Nathanson, K.L. (Katherine), Floris, O.A.M., Nevanlinna, H. (Heli), Nielsen, F.C. (Finn C.), O’Brien, K.M. (Katie M.), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Osorio, A. (Ana), Ottini, L. (Laura), Park-Simon, T.-W. (Tjoung-Won), Parsons, M. (Marilyn), Pedersen, I.S. (Inge Sokilde), Peshkin, B. (Beth), Peterlongo, P. (Paolo), Peto, J. (Julian), Pharoah, P.D.P. (Paul), Phillips, K.-A. (Kelly-Anne), Polley, E.C. (Eric C.), Poppe, B. (Bruce), Presneau, N. (Nadege), Pujana, M.A. (Miquel Angel), Punie, K. (Kevin), Rantala, J. (Johanna), Rashid, M.U. (Muhammad), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Robson, M. (Mark), Romero, A. (Atocha), Rossing, M. (Maria), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Santella, R.M. (Regina), Scheuner, M.T. (Maren T.), Schmidt, M.K. (Marjanka K.), Schmidt, G. (Gunnar), Scott, C. (Christopher), Sharma, P. (Priyanka), Soucy, P. (Penny), Southey, M.C. (Melissa C.), Spinelli, J.J. (John J.), Steinsnyder, Z. (Zoe), Stone, J. (Jennifer), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Taylor, J.A. (Jack A.), Terry, M.B. (Mary Beth), Teulé, A. (Alex), Thull, D.L. (Darcy L.), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Trainer, A.H. (Alison H.), Truong, T. (Thérèse), Tung, N. (Nadine), Vachon, C. (Celine), Vega, A. (Ana), Joseph, V. (Vijai), Wang, Q. (Qin), Wappenschmidt, B. (Barbara), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wendt, C. (Camilla), Wolk, K. (Kerstin), Yadav, S. (Siddhartha), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Park, S.K. (Sue K.), Thomassen, M. (Mads), Offit, K. (Kenneth), Schmutzler, R.K. (Rita), Couch, F.J. (Fergus), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Adamo, P. (Pio) d', Andrieu, N. (Nadine), Antoniou, A.C. (Antonis C.), Coignard, J. (Juliette), Lush, M. (Michael), Beesley, J. (Jonathan), O’Mara, T.A. (Tracy A.), Dennis, J. (Joe), Tyrer, J.P. (Jonathan P.), Barnes, D. (Daniel), McGuffog, L. (Lesley), Leslie, G. (Goska), Bolla, M.K. (Manjeet K.), Adank, M.A. (Muriel), Agata, S. (Simona), Ahearn, T. (Thomas), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene L.), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arnold, N. (Norbert), Aronson, K.J. (Kristan J.), Arun, B.K. (Banu), Augustinsson, A. (Annelie), Azzollini, J., Barrowdale, D. (Daniel), Baynes, C. (Caroline), Becher, H. (Heko), Bermisheva, M. (Marina), Bernstein, L. (Leslie), Białkowska, K. (Katarzyna), Blomqvist, C. (Carl), Bojesen, S.E. (Stig), Bonnani, B. (Bernardo), Borg, Å. (Åke), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria A.), Campa, D. (Daniele), Carter, B.D. (Brian D.), Castelao, J.E. (Jose ), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B. M.), Clarke, C.L. (Christine L.), Bertrand, O. (Ophélie), Caputo, S. (Sandrine), Dupré, A. (Anaïs), Le Mentec, M. (Marine), Belotti, M. (Muriel), Birot, A.-M. (Anne-Marie), Buecher, B. (Bruno), Fourme, E. (Emmanuelle), Gauthier-Villars, M. (Marion), Golmard, L. (Lisa), Houdayer, C. (Claude), Moncoutier, V. (Virginie), de Pauw, A. (Antoine), Saule, C. (Claire), Sinilnikova, O. (Olga), Mazoyer, S. (Sylvie), Damiola, F. (Francesca), Barjhoux, L. (Laure), Verny-Pierre, C. (Carole), Léone, M. (Mélanie), Boutry-Kryza, N. (N.), Calender, A. (Alain), Giraud, S. (Sophie), Caron, O. (Olivier), Guillaud-Bataille, M. (Marine), Bressac-de Paillerets, B. (Brigitte), Bignon, Y.-J. (Yves-Jean), Uhrhammer, N. (Nancy), Lasset, C. (Christine), Bonadona, V. (Valérie), Berthet, P. (Pascaline), Vaur, D. (Dominique), Castera, L. (Laurent), Noguchi, T. (Tetsuro), Popovici, C. (Cornel), Sobol, H. (Hagay), Bourdon, V. (Violaine), Remenieras, A. (Audrey), Nogues, C. (Catherine), Coupier, I. (Isabelle), Pujol, P. (Pascal), Dumont, A. (Aurélie), Révillion, F. (Françoise), Adenis, C. (Claude), Muller, D.W. (Danièle), Barouk-Simonet, E. (Emmanuelle), Bonnet, F. (Françoise), Bubien, V. (Virginie), Sevenet, N. (Nicolas), Longy, M. (Michel), Toulas, C. (Christine), Guimbaud, R. (Rosine), Gladieff, L. (Laurence), Feillel, V. (Viviane), Leroux, D. (Dominique), Dreyfus, H. (Hélène), Rebischung, C. (Christine), Peysselon, M. (Magalie), Coron, F. (Fanny), Faivre, L. (Laurence), Baurand, A. (Amandine), Jacquot, C. (Caroline), Bertolone, G. (Geoffrey), Lizard, S. (Sarab), Prieur, F. (Fabienne), Lebrun, M. (Marine), Kientz, C. (Caroline), Ferrer, S.F., Mari, V. (Véronique), Vénat-Bouvet, L. (Laurence), Delnatte, C. (Capucine), Bézieau, S. (Stéphane), Mortemousque, I. (Isabelle), Coulet, F. (Florence), Colas, C. (Chrystelle), Soubrier, F. (Florent), Warcoin, M. (Mathilde), Sokolowska, J. (Johanna), Bronner, M. (Myriam), Collonge-Rame, M.-A., Damette, A. (Alexandre), Gesta, P. (Paul), Lallaoui, H. (Hakima), Chiesa, J. (Jean), Molina-Gomes, D. (Denise), Ingster, O. (Olivier), Gregory, H. (Helen), Miedzybrodzka, Z. (Zosia), Morrison, P.J. (Patrick J.), Ong, K.-R. (Kai-ren), Donaldson, A. (Alan), Rogers, M.T. (Mark), Kennedy, M.J. (M. John), Porteous, M.E. (Mary), Brewer, C. (Carole), Davidson, R. (Rosemarie), Izatt, L. (Louise), Brady, A. (A.), Barwell, J. (Julian), Adlard, J.W. (Julian), Foo, C. (Claire), Lalloo, F. (Fiona), Side, L.E. (Lucy E.), Eason, J. (Jacqueline), Henderson, A. (Alex), Walker, L. (Lisa), Eeles, R. (Rosalind), Cook, J. (Jackie), Snape, K. (Katie), Eccles, D. (Diana), Murray, A. (Alexandra), McCann, E. (Emma), Collée, J.M. (J. Margriet), Conroy, D.M. (Don M.), Czene, K. (Kamila), Daly, M.B. (Mary B.), Devilee, P. (Peter), Diez, O. (Orland), Ding, Y.C. (Yuan Chun), Domchek, S.M. (Susan), Dörk, T. (Thilo), Santos Silva, I. (Isabel) dos, Dunning, A.M. (Alison M.), Dwek, M. (Miriam), Eccles, D.M. (Diana M.), Eliassen, A.H. (A. Heather), Engel, C. (Christoph), Eriksson, M. (Mikael), Evans, D.G. (D. Gareth), Fasching, P.A. (Peter), Flyger, H. (Henrik), Fostira, F. (Florentia), Friedman, E. (Eitan), Fritschi, L. (Lin), Frost, D. (Debra), Gago-Dominguez, M. (Manuela), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Garcia-Barberan, V. (Vanesa), García-Closas, M. (Montserrat), García-Sáenz, J.A. (José A.), Gaudet, M.M. (Mia M.), Gayther, S.A. (Simon), Gehrig, A. (Andrea), Georgoulias, V. (Vassilios), Giles, G.G. (Graham G.), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Radice, P. (Paolo), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Guénel, P. (Pascal), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C.A. (Christopher), Håkansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P.A. (Patricia A.), Hart, S.N. (Steven N.), He, W. (Wei), Hogervorst, F.B.L. (Frans B. L.), Hollestelle, A. (Antoinette), Hopper, J.L. (John), Horcasitas, D.J. (Darling J.), Hulick, P.J. (Peter J.), Hunter, D.J. (David J.), Imyanitov, E.N. (Evgeny), Fox, S.B. (Stephen), Campbell, I. (Ian), Spurdle, A. (Amanda), Webb, P. (Penny), De Fazio, A. (Anna), Tassell, M. (Margaret), Kirk, J. (Judy), Lindeman, G.J. (Geoffrey), Price, M. (Melanie), Southey, M.C. (Melissa), Milne, R.L. (Roger), Deb, S. (Sid), Bowtell, D. (David), Hout, A.H. (Annemarie) van der, Ouweland, A.M.W. (Ans) van den, Mensenkamp, A.R. (Arjen R.), Deurzen, C.H.M. (Carolien) van, Kets, C.M. (Marleen), Seynaeve, C.M. (Caroline), van Asperen, C.J. (Christi J.), Aalfs, C.M. (Cora), Gómez Garcia, E.B. (Encarna B.), Leeuwen, F.E. (Flora) van, Bock, G.H. (Geertruida) de, Meijers-Heijboer, E.J. (Hanne), Obdeijn, A.I.M. (Inge-Marie), Gille, J.J.P. (J. J.P.), Oosterwijk, J.C. (Jan), Wijnen, J.T. (Juul), Kolk, L.E. (Lizet) van der, Hooning, M.J. (Maartje), Ausems, M.G.E.M. (Margreet), Mourits, M.J. (Marjan), Blok, M.J. (Marinus J.), Rookus, M.A. (Matti), van der Luijt, R.B. (Rob B.), Cronenburg, T.C.T.E.F. van, Pol, C. (Carmen) van der, Russell, N.S. (Nicola), Siesling, S. (Sabine), Overbeek, L.I.H. (Lucy), Wijnands, R. (R.), Lange, J.L. (J.) de, Clarke, C. (Christine), Graham, D. (Dinny), Sachchithananthan, M. (Mythily), Marsh, D. (Deborah), Scott, R.J. (Rodney), Baxter, R. (Robert), Yip, D. (Desmond), Carpenter, T.A. (Adrian), Davis, A. (Alison), Pathmanathan, N. (Nirmala), Simpson, P. (Peter), Jager, A. (Agnes), Jakubowska, A. (Anna), James, M. (Margaret), Jensen, U.B. (Uffe Birk), John, E.M. (Esther), Jones, M.E. (Michael E.), Kaaks, R. (Rudolf), Kapoor, P.M. (Pooja Middha), Karlan, B.Y. (Beth), Keeman, R. (Renske), Khusnutdinova, E.K. (Elza), Kiiski, J.I. (Johanna I.), Ko, Y.-D. (Yon-Dschun), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kurian, A.W. (Allison W.), Laitman, Y. (Yael), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lester, J. (Jenny), Lesueur, F. (Fabienne), Lindstrom, T. (Tricia), Lopez-Fernández, A. (Adria), Loud, J.T. (Jennifer T.), Luccarini, C. (Craig), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J.W.M. (John), Mebirouk, N. (Noura), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger L.), Montagna, M. (Marco), Nathanson, K.L. (Katherine), Floris, O.A.M., Nevanlinna, H. (Heli), Nielsen, F.C. (Finn C.), O’Brien, K.M. (Katie M.), Olopade, O.I. (Olofunmilayo), Olson, J.E. (Janet), Olsson, H. (Håkan), Osorio, A. (Ana), Ottini, L. (Laura), Park-Simon, T.-W. (Tjoung-Won), Parsons, M. (Marilyn), Pedersen, I.S. (Inge Sokilde), Peshkin, B. (Beth), Peterlongo, P. (Paolo), Peto, J. (Julian), Pharoah, P.D.P. (Paul), Phillips, K.-A. (Kelly-Anne), Polley, E.C. (Eric C.), Poppe, B. (Bruce), Presneau, N. (Nadege), Pujana, M.A. (Miquel Angel), Punie, K. (Kevin), Rantala, J. (Johanna), Rashid, M.U. (Muhammad), Rennert, G. (Gad), Rennert, H.S. (Hedy S.), Robson, M. (Mark), Romero, A. (Atocha), Rossing, M. (Maria), Saloustros, E. (Emmanouil), Sandler, D.P. (Dale P.), Santella, R.M. (Regina), Scheuner, M.T. (Maren T.), Schmidt, M.K. (Marjanka K.), Schmidt, G. (Gunnar), Scott, C. (Christopher), Sharma, P. (Priyanka), Soucy, P. (Penny), Southey, M.C. (Melissa C.), Spinelli, J.J. (John J.), Steinsnyder, Z. (Zoe), Stone, J. (Jennifer), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Tamimi, R. (Rulla), Tapper, W.J. (William J.), Taylor, J.A. (Jack A.), Terry, M.B. (Mary Beth), Teulé, A. (Alex), Thull, D.L. (Darcy L.), Tischkowitz, M. (Marc), Toland, A.E. (Amanda), Torres, D. (Diana), Trainer, A.H. (Alison H.), Truong, T. (Thérèse), Tung, N. (Nadine), Vachon, C. (Celine), Vega, A. (Ana), Joseph, V. (Vijai), Wang, Q. (Qin), Wappenschmidt, B. (Barbara), Weinberg, C.R. (Clarice R.), Weitzel, J.N. (Jeffrey), Wendt, C. (Camilla), Wolk, K. (Kerstin), Yadav, S. (Siddhartha), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Ziogas, A. (Argyrios), Zorn, K.K. (Kristin K.), Park, S.K. (Sue K.), Thomassen, M. (Mads), Offit, K. (Kenneth), Schmutzler, R.K. (Rita), Couch, F.J. (Fergus), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Adamo, P. (Pio) d', Andrieu, N. (Nadine), and Antoniou, A.C. (Antonis C.)
Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
Published: 2021
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27. Missing not at random in end of life care studies: multiple imputation and sensitivity analysis on data from the ACTION study

Author: Carreras, G. (Giulia), Miccinesi, G. (Guido), Wilcock, A. (Andrew), Preston, N.J. (Nancy J.), Nieboer, D. (Daan), Deliens, L. (Luc), Groenvold, M. (Mogensm), Lunder, U. (Urska), Heide, A. (Agnes) van der, Baccini, M. (Michela), Korfage, I.J. (Ida), Rietjens, J.A.C. (Judith), Jabbarian, L.J. (Lea), Polinder, S. (Suzanne), Delden, J.J.M. (Hans) van, Kars, M.C. (Marijke), Zwakman, M. (Marieke), Verkissen, M.N. (Mariëtte N.), Eecloo, K. (Kim), Faes, K. (Kristof), Pollock, K. (Kristian), Seymour, J. (Jane), Caswell, G. (Glenys), Bramley, L. (Louise), Payne, S. (Sheila), Dunleavy, L. (Lesley), Sowerby, E. (Eleanor), Bulli, F. (Francesco), Ingravallo, F. (Francesca), Toccafondi, A. (Alessandro), Gorini, G. (Giuseppe), Červ, B. (Branka), Simonič, A. (Anja), Mimić, A. (Alenka), Kodba-Čeh, H. (Hana), Ozbič, P. (Polona), Groenvold, M. (M.), Arnfeldt, C. (Caroline), Thit Johnsen, A. (Anna), Carreras, G. (Giulia), Miccinesi, G. (Guido), Wilcock, A. (Andrew), Preston, N.J. (Nancy J.), Nieboer, D. (Daan), Deliens, L. (Luc), Groenvold, M. (Mogensm), Lunder, U. (Urska), Heide, A. (Agnes) van der, Baccini, M. (Michela), Korfage, I.J. (Ida), Rietjens, J.A.C. (Judith), Jabbarian, L.J. (Lea), Polinder, S. (Suzanne), Delden, J.J.M. (Hans) van, Kars, M.C. (Marijke), Zwakman, M. (Marieke), Verkissen, M.N. (Mariëtte N.), Eecloo, K. (Kim), Faes, K. (Kristof), Pollock, K. (Kristian), Seymour, J. (Jane), Caswell, G. (Glenys), Bramley, L. (Louise), Payne, S. (Sheila), Dunleavy, L. (Lesley), Sowerby, E. (Eleanor), Bulli, F. (Francesco), Ingravallo, F. (Francesca), Toccafondi, A. (Alessandro), Gorini, G. (Giuseppe), Červ, B. (Branka), Simonič, A. (Anja), Mimić, A. (Alenka), Kodba-Čeh, H. (Hana), Ozbič, P. (Polona), Groenvold, M. (M.), Arnfeldt, C. (Caroline), and Thit Johnsen, A. (Anna)
Abstract: Background: Missing data are common in end-of-life care studies, but there is still relatively little exploration of which is the best method to deal with them, and, in particular, if the missing at random (MAR) assumption is valid or missing not at random (MNAR) mechanisms should be assumed. In this paper we investigated this issue through a sensitivity analysis within the ACTION study, a multicenter cluster randomized controlled trial testing advance care planning in patients with advanced lung or colorectal cancer. Methods: Multiple imputation procedures under MAR and MNAR assumptions were implemented. Possible violation of the MAR assumption was addressed with reference to variables measuring quality of life and symptoms. The MNAR model assumed that patients with worse health were more likely to have missing questionnaires, making a distinction between single missing items, which were assumed to satisfy the MAR assumption, and missing values due to completely missing questionnaire for which a MNAR mechanism was hypothesized. We explored the sensitivity to possible departures from MAR on gender differences between k
Published: 2021
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28. Computable trustworthiness ranking of medical experts in Italy during the SARS-CoV-19 pandemic

Author: Ceolin, D. (Davide), Doneda, F. (Francesca), Primiero, G. (Giuseppe), Ceolin, D. (Davide), Doneda, F. (Francesca), and Primiero, G. (Giuseppe)
Abstract: Source trustworthiness can help discerning reliable and truthful information. We offer a computable model for the dynamic assessment of sources trustworthiness based on their popularity, knowledge-ability, and reputation. We apply it to the debate among medical experts in Italy during three distinct phases of the SARS-CoV-19 pandemic, and validate it against a dataset of newspaper articles. The model shows promising results in the analysis of expert debates their impact on public opinion.
Published: 2021
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29. Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019:a three-stage modelling study

Author: Zhao, Q. (Qi), Guo, Y. (Yuming), Ye, T. (Tingting), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Van Dung, D. (Do), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), de'Donato, F. (Francesca), Di Ruscio, F. (Francesco), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), de Sousa Zanotti Stagliorio Coelho, M. (Micheline), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Saldiva, P. H. (Paulo Hilario Nascimento), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Rao, S. (Shilpa), Fratianni, S. (Simona), Dang, T. N. (Tran Ngoc), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), Li, S. (Shanshan), Zhao, Q. (Qi), Guo, Y. (Yuming), Ye, T. (Tingting), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Van Dung, D. (Do), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), de'Donato, F. (Francesca), Di Ruscio, F. (Francesco), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), de Sousa Zanotti Stagliorio Coelho, M. (Micheline), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Saldiva, P. H. (Paulo Hilario Nascimento), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Rao, S. (Shilpa), Fratianni, S. (Simona), Dang, T. N. (Tran Ngoc), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), and Li, S. (Shanshan)
Abstract: Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. A three-stage analysis strategy was used. First, the temperature–mortality association was fitted for each location by use of a time-series regression. Second, a multivariate meta-regression model was built between location-specific estimates and meta-predictors. Finally, the grid-specific temperature–mortality association between 2000 and 2019 was predicted by use of the fitted meta-regression and the grid-specific meta-predictors. Excess deaths due to non-optimal temperatures, the ratio between annual excess deaths and all deaths of a year (the excess death ratio), and the death rate per 100 000 residents were then calculated for each grid across the world. Grids were divided according to regional groupings of the UN Statistics Division. Findings: Globally, 5 083 173 deaths (95% empirical CI [eCI] 4 087 967–5 965 520) were associated with non-optimal temperatures per year, accounting for 9·43% (95% eCI 7·58–11·07) of all deaths (8·52% [6·19–10·47] were cold-related and 0·91% [0·56–1·36] were heat-related). There were 74 temperature-related excess deaths per 100 000 residents (95% eCI 60–87). The mortality burden varied geographically. Of all excess deaths, 2 617 322 (51·49%) occurred in Asia. Eastern Europe had the highest heat-related excess death rate and Sub-Saharan Africa had the highest cold-related excess death rate. From 2000–03 to 2016–19, the global cold-related excess death ratio changed by −0·51 percentage points (95% eCI −0·61 to −0·42) and the global heat-related excess death ratio increased by 0·21 percentage points (0·13–0·31), l
Published: 2021

30. Real-world experiences in autistic adult diagnostic services and post-diagnostic support and alignment with services guidelines:results from the ASDEU study

Author: Scattoni, M. L. (Maria Luisa), Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Rogé, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leósdóttir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Célia), Budişteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia García), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), Schendel, D. (Diana), Scattoni, M. L. (Maria Luisa), Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Rogé, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leósdóttir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Célia), Budişteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia García), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), and Schendel, D. (Diana)
Abstract: Research providing an evidence-base for autistic adult services is sparse. The Autism Spectrum Disorders in the European Union (ASDEU) network implemented an on-line survey to determine gaps in autistic adult diagnostic evaluation and post-diagnostic support services. More than 55% in all groups experienced most of the recommended features for diagnostic evaluation for autistic adults. In contrast, < 2% of adults or carers, and < 21% of professionals experienced each of the recommended features for post-diagnostic support. In contrast to 61% of professionals, only about 30% of autistic adults and carers had knowledge of good local services models for autism diagnosis in adulthood. There are major differences between good practice guidelines for diagnostic and post-diagnostic care for autistic adults, and what is actually experienced by services users and professionals.
Published: 2021

31. Autistic adult health and professional perceptions of it:evidence from the ASDEU project

Author: Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Rogé, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leósdóttir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Célia), Budişteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia García), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), Scattoni, M. L. (Maria Luisa), Schendel, D. (Diana), Micai, M. (Martina), Ciaramella, A. (Antonio), Salvitti, T. (Tommaso), Fulceri, F. (Francesca), Fatta, L. M. (Laura Maria), Poustka, L. (Luise), Diehm, R. (Robert), Iskrov, G. (Georgi), Stefanov, R. (Rumen), Guillon, Q. (Quentin), Rogé, B. (Bernadette), Staines, A. (Anthony), Sweeney, M. R. (Mary Rose), Boilson, A. M. (Andrew Martin), Leósdóttir, T. (Thora), Saemundsen, E. (Evald), Moilanen, I. (Irma), Ebeling, H. (Hanna), Yliherva, A. (Anneli), Gissler, M. (Mika), Parviainen, T. (Tarja), Tani, P. (Pekka), Kawa, R. (Rafal), Vicente, A. (Astrid), Rasga, C. (Célia), Budişteanu, M. (Magdalena), Dale, I. (Ian), Povey, C. (Carol), Flores, N. (Noelia), Jenaro, C. (Cristina), Monroy, M. L. (Maria Luisa), Primo, P. G. (Patricia García), Charman, T. (Tony), Cramer, S. (Susanne), Warberg, C. K. (Christine Kloster), Canal-Bedia, R. (Ricardo), Posada, M. (Manuel), Scattoni, M. L. (Maria Luisa), and Schendel, D. (Diana)
Abstract: The Autism Spectrum Disorders in the European Union (ASDEU) survey investigated the knowledge and health service experiences of users and providers to generate new hypotheses and scientific investigations that would contribute to improvement in health care for autistic adults. An online survey designed for autistic adults, carers of autistic adults, and professionals in adult services was translated into 11 languages and distributed electronically by organizations and in-country adult service facilities in 2017; 522 autistic adults, 442 carers, and 113 professionals provided answers to the health questions. Professionals, the majority in non-medical services, appeared to be poorly informed about whether certain co-occurring conditions were more frequent in autistic adults than typical adults—especially some medical conditions, suicide attempts, accidents, and pain. A minority of autistic adults reported preventive health behaviors such as routine health check-ups. The majority of users and providers expressed the desire to make health care services more user-friendly for autistic adults. Among the three groups, <20% of responders knew an organization or clinician which has developed a way to monitor health, and prevent poor health, that works well for adults on the autism spectrum. The results point to means for better management of co-occurring conditions associated with autism in adulthood in order to reduce hospital admissions and potential areas of improvement in health and social services for autistic adults. Specifically, efforts should be focused on (1) professionals’ education on risks for co-occurring conditions in autistic adults; (2) promoting preventive health behaviors; (3) making services user-friendly for autistic adults and their families; and (4) encouraging knowledge of good local services.
Published: 2021

32. Health systems strengthening to arrest the global disability burden:empirical development of prioritised components for a global strategy for improving musculoskeletal health

Author: Briggs, A. M. (Andrew M.), Huckel Schneider, C. (Carmen), Slater, H. (Helen), Jordan, J. E. (Joanne E), Parambath, S. (Sarika), Young, J. J. (James J.), Sharma, S. (Saurab), Kopansky- Giles, D. (Deborah), Mishrra, S. (Swatee), Akesson, K. E. (Kristina E.), Ali, N. (Nuzhat), Belton, J. (Joletta), Betteridge, N. (Neil), Blyth, F. M. (Fiona M.), Brown, R. (Richard), Debere, D. (Demelash), Dreinhöfer, K. E. (Karsten E.), Finucane, L. (Laura), Foster, H. E. (Helen E.), Gimigliano, F. (Francesca), Haldeman, S. (Scott), Haq, S. A. (Syed A.), Horgan, B. (Ben), Jain, A. (Anil), Joshipura, M. (Manjul), Kalla, A. A. (Asgar A.), Lothe, J. (Jakob), Matsuda, S. (Shuichi), Mobasheri, A. (Ali), Mwaniki, L. (Lillian), Nordin, M. C. (Margareta C.), Pattison, M. (Marilyn), Reis, F. J. (Felipe J. J.), Soriano, E. R. (Enrique R.), Tick, H. (Heather), Waddell, J. (James), Wiek, D. (Dieter), Woolf, A. D. (Anthony D.), March, L. (Lyn), Briggs, A. M. (Andrew M.), Huckel Schneider, C. (Carmen), Slater, H. (Helen), Jordan, J. E. (Joanne E), Parambath, S. (Sarika), Young, J. J. (James J.), Sharma, S. (Saurab), Kopansky- Giles, D. (Deborah), Mishrra, S. (Swatee), Akesson, K. E. (Kristina E.), Ali, N. (Nuzhat), Belton, J. (Joletta), Betteridge, N. (Neil), Blyth, F. M. (Fiona M.), Brown, R. (Richard), Debere, D. (Demelash), Dreinhöfer, K. E. (Karsten E.), Finucane, L. (Laura), Foster, H. E. (Helen E.), Gimigliano, F. (Francesca), Haldeman, S. (Scott), Haq, S. A. (Syed A.), Horgan, B. (Ben), Jain, A. (Anil), Joshipura, M. (Manjul), Kalla, A. A. (Asgar A.), Lothe, J. (Jakob), Matsuda, S. (Shuichi), Mobasheri, A. (Ali), Mwaniki, L. (Lillian), Nordin, M. C. (Margareta C.), Pattison, M. (Marilyn), Reis, F. J. (Felipe J. J.), Soriano, E. R. (Enrique R.), Tick, H. (Heather), Waddell, J. (James), Wiek, D. (Dieter), Woolf, A. D. (Anthony D.), and March, L. (Lyn)
Abstract: Introduction: Despite the profound burden of disease, a strategic global response to optimise musculoskeletal (MSK) health and guide national-level health systems strengthening priorities remains absent. Auspiced by the Global Alliance for Musculoskeletal Health (G-MUSC), we aimed to empirically derive requisite priorities and components of a strategic response to guide global and national-level action on MSK health. Methods: Design: mixed-methods, three-phase design. Phase 1: qualitative study with international key informants (KIs), including patient representatives and people with lived experience. KIs characterised the contemporary landscape for MSK health and priorities for a global strategic response. Phase 2: scoping review of national health policies to identify contemporary MSK policy trends and foci. Phase 3: informed by phases 1–2, was a global eDelphi where multisectoral panellists rated and iterated a framework of priorities and detailed components/actions. Results: Phase 1: 31 KIs representing 25 organisations were sampled from 20 countries (40% low and middle income (LMIC)). Inductively derived themes were used to construct a logic model to underpin latter phases, consisting of five guiding principles, eight strategic priority areas and seven accelerators for action. Phase 2: of the 165 documents identified, 41 (24.8%) from 22 countries (88% high-income countries) and 2 regions met the inclusion criteria. Eight overarching policy themes, supported by 47 subthemes, were derived, aligning closely with the logic model. Phase 3: 674 panellists from 72 countries (46% LMICs) participated in round 1 and 439 (65%) in round 2 of the eDelphi. Fifty-nine components were retained with 10 (17%) identified as essential for health systems. 97.6% and 94.8% agreed or strongly agreed the framework was valuable and credible, respectively, for health systems strengthening. Conclusion: An empirically derived framework, co-designed and strongly supported by multis
Published: 2021

33. Evaluation of the ERA5 reanalysis-based Universal Thermal Climate Index on mortality data in Europe

Author: Urban, A. (Aleš), Di Napoli, C. (Claudia), Cloke, H. L. (Hannah L.), Kyselý, J. (Jan), Pappenberger, F. (Florian), Sera, F. (Francesco), Schneider, R. (Rochelle), Vicedo-Cabrera, A. M. (Ana M.), Acquaotta, F. (Fiorella), Ragettli, M. S. (Martina S.), Íñiguez, C. (Carmen), Tobias, A. (Aurelio), Indermitte, E. (Ene), Orru, H. (Hans), Jaakkola, J. J. (Jouni J. K.), Ryti, N. R. (Niilo R. I.), Pascal, M. (Mathilde), Huber, V. (Veronika), Schneider, A. (Alexandra), de’ Donato, F. (Francesca), Michelozzi, P. (Paola), Gasparrini, A. (Antonio), Urban, A. (Aleš), Di Napoli, C. (Claudia), Cloke, H. L. (Hannah L.), Kyselý, J. (Jan), Pappenberger, F. (Florian), Sera, F. (Francesco), Schneider, R. (Rochelle), Vicedo-Cabrera, A. M. (Ana M.), Acquaotta, F. (Fiorella), Ragettli, M. S. (Martina S.), Íñiguez, C. (Carmen), Tobias, A. (Aurelio), Indermitte, E. (Ene), Orru, H. (Hans), Jaakkola, J. J. (Jouni J. K.), Ryti, N. R. (Niilo R. I.), Pascal, M. (Mathilde), Huber, V. (Veronika), Schneider, A. (Alexandra), de’ Donato, F. (Francesca), Michelozzi, P. (Paola), and Gasparrini, A. (Antonio)
Abstract: Air temperature has been the most commonly used exposure metric in assessing relationships between thermal stress and mortality. Lack of the high-quality meteorological station data necessary to adequately characterize the thermal environment has been one of the main limitations for the use of more complex thermal indices. Global climate reanalyses may provide an ideal platform to overcome this limitation and define complex heat and cold stress conditions anywhere in the world. In this study, we explored the potential of the Universal Thermal Climate Index (UTCI) based on ERA5 — the latest global climate reanalysis from the European Centre for Medium-Range Weather Forecasts (ECMWF) — as a health-related tool. Employing a novel ERA5-based thermal comfort dataset ERA5-HEAT, we investigated the relationships between the UTCI and daily mortality data in 21 cities across 9 European countries. We used distributed lag nonlinear models to assess exposure-response relationships between mortality and thermal conditions in individual cities. We then employed meta-regression models to pool the results for each city into four groups according to climate zone. To evaluate the performance of ERA5-based UTCI, we compared its effects on mortality with those for the station-based UTCI data. In order to assess the additional effect of the UTCI, the performance of ERA5-and station-based air temperature (T) was evaluated. Whilst generally similar heat- and cold-effects were observed for the ERA5-and station-based data in most locations, the important role of wind in the UTCI appeared in the results. The largest difference between any two datasets was found in the Southern European group of cities, where the relative risk of mortality at the 1st percentile of daily mean temperature distribution (1.29 and 1.30 according to the ERA5 vs station data, respectively) considerably exceeded the one for the daily mean UTCI (1.19 vs 1.22). These differences were mainly due to the effect o
Published: 2021

34. Weather conditions and COVID-19 incidence in a cold climate:a time-series study in Finland

Author: Heibati, B. (Behzad), Wang, W. (Wenge), Ryti, N. R. (Niilo R. I.), Dominici, F. (Francesca), Ducatman, A. (Alan), Zhang, Z. (Zhijie), Jaakkola, J. J. (Jouni J. K.), Heibati, B. (Behzad), Wang, W. (Wenge), Ryti, N. R. (Niilo R. I.), Dominici, F. (Francesca), Ducatman, A. (Alan), Zhang, Z. (Zhijie), and Jaakkola, J. J. (Jouni J. K.)
Abstract: Background: The current coronavirus disease 2019 (COVID-19) is spreading globally at an accelerated rate. There is some previous evidence that weather may influence the incidence of COVID-19 infection. We assessed the role of meteorological factors including temperature (T) and relative humidity (RH) considering the concentrations of two air pollutants, inhalable coarse particles (PM₁₀) and nitrogen dioxide (NO₂) in the incidence of COVID-19 infections in Finland, located in arctic-subarctic climatic zone. Methods: We retrieved daily counts of COVID-19 in Finland from Jan 1 to May 31, 2020, nationwide and separately for all 21 hospital districts across the country. The meteorological and air quality data were from the monitoring stations nearest to the central district hospital. A quasi-Poisson generalized additional model (GAM) was fitted to estimate the associations between district-specific meteorological factors and the daily counts of COVID-19 during the study period. Sensitivity analyses were conducted to test the robustness of the results. Results: The incidence rate of COVID-19 gradually increased until a peak around April 6 and then decreased. There were no associations between daily temperature and incidence rate of COVID-19. Daily average RH was negatively associated with daily incidence rate of COVID-19 in two hospital districts located inland. No such association was found nationwide. Conclusions: Weather conditions, such as air temperature and relative humidity, were not related to the COVID-19 incidence during the first wave in the arctic and subarctic winter and spring. The inference is based on a relatively small number of cases and a restricted time period.
Published: 2021

35. «Che cosa pensa un medico...» Rileggendo Nel museo di Reims di Daniele Del Giudice

Author: Casadei, Alberto, Fedi, Francesca, Nacinovich, Annalisa, Torre, Andrea, Casadei, A ( Alberto ), Fedi, F ( Francesca ), Nacinovich, A ( Annalisa ), Torre, A ( Andrea ), De Marchi, Pietro, Casadei, Alberto, Fedi, Francesca, Nacinovich, Annalisa, Torre, Andrea, Casadei, A ( Alberto ), Fedi, F ( Francesca ), Nacinovich, A ( Annalisa ), Torre, A ( Andrea ), and De Marchi, Pietro
Published: 2021

36. Exile

Author: Gragnolati, Manuele, Lombardi, Elena, Southerden, Francesca, Gragnolati, M ( Manuele ), Lombardi, E ( Elena ), Southerden, F ( Francesca ), Bartuschat, Johannes; https://orcid.org/0000-0003-0268-1324, Gragnolati, Manuele, Lombardi, Elena, Southerden, Francesca, Gragnolati, M ( Manuele ), Lombardi, E ( Elena ), Southerden, F ( Francesca ), and Bartuschat, Johannes; https://orcid.org/0000-0003-0268-1324
Abstract: This chapter examines the way the poet represents his exile. It is composed of three parts: the first considers the way Dante handles his exile in relation to authorship, and reveals how he constructs his authority from his position as an exile in the Convivio, De vulgari eloquentia, and his Epistles. The second analyses exile as a major element of the autobiographical dimension of the Commedia. It shows that the necessity to grasp the moral lesson of the exile constitutes the very heart of the poem. The third part explores the relationship between exile and pilgrimage, the latter being, from the Vita Nuova onwards, a symbol of the human condition, and demonstrates how Dante interprets his experience both as an exile and as a wanderer in the other world in the light of pilgrimage.
Published: 2021

37. Il valore della guerra: il bottino di Giornico nella memoria collettiva e nella storiografia dei cantoni svizzeri

Author: Ostinelli, Paolo, Luisoni, Francesca, Ostinelli, P ( Paolo ), Luisoni, F ( Francesca ), Ostinelli, Paolo, Luisoni, Francesca, Ostinelli, P ( Paolo ), and Luisoni, F ( Francesca )
Published: 2021

38. Germanic names, vernacular sounds, and Latin spellings in early Anglo-Saxon and Alemannic charters

Author: Gallagher, Robert, Roberts, Edward, Tinti, Francesca, Gallagher, R ( Robert ), Roberts, E ( Edward ), Tinti, F ( Francesca ), Seiler, Annina; https://orcid.org/0000-0003-3576-1435, Gallagher, Robert, Roberts, Edward, Tinti, Francesca, Gallagher, R ( Robert ), Roberts, E ( Edward ), Tinti, F ( Francesca ), and Seiler, Annina; https://orcid.org/0000-0003-3576-1435
Abstract: This chapter focuses on the graphemic representation of names in early single-sheet charters from Anglo-Saxon England and from the abbey of St Gall. Personal and place-names in Latin charters are among the earliest written evidence for Old English and Old High German. Given their ambiguous lexico-semantic status, scribes could choose whether to treat names as vernacular items or as part of the Latin (con)text. This is reflected in the spellings which they use for the representation of specifically Germanic sounds as well as in their choice of inflectional endings. An analysis of the distribution of these features shows that there is a strong correlation between spellings/endings and different sections of the charters: Latinized spellings and case endings dominate in the dispositive section of charters, whereas more vernacular forms are used in the witness list and, for the St Gall charters, in the charter drafts. A second factor that influences the written representation of names is the social status of the people involved: the names of important people, such as kings, counts or bishops, are more often Latinized than those of more ordinary witnesses. Moreover, the type of name also plays a role as place-names generally display a higher degree of vernacular features than personal names. Thus, the graphemic variation attested in these charters turns out to be highly functional and is indicative of different communicative purposes attached to separate sections of the charters.
Published: 2021

39. IPython notebook with 'Computable Trustworthiness Ranking of Medical Experts in Italy during the SARS-CoV-19 Pandemic'

Author: Ceolin, D. (Davide), Doneda, F. (Francesca), Primiero, G. (Giuseppe), Ceolin, D. (Davide), Doneda, F. (Francesca), and Primiero, G. (Giuseppe)
Published: 2021

40. Data with 'Computable Trustworthiness Ranking of Medical Experts in Italy during the SARS-CoV-19 Pandemic'

Author: Ceolin, D. (Davide), Doneda, F. (Francesca), Primiero, G. (Giuseppe), Ceolin, D. (Davide), Doneda, F. (Francesca), and Primiero, G. (Giuseppe)
Published: 2021

41. Report of the Working Group on Biological Parameters (WGBIOP) 2020

Author: Aanestad, J., Allegaert, Wim, Beier, U., Bekaert, K. (Karen), Canha, A.M.L. (Ángela M.L.), Carbonara, P. (Pierluigi), Davies, J.L. (Julie Coad), Farias, Inês, Follesa, M.C. (Maria Cristina), Gault, Mandy, Gillespie-Mules, R. (Ruadhán), Haase, S. (Stephanie), Hilvarsson, A. (Annelie), Hüssy, K. (Karin), Korta, M. (María), Krüger-Johnsen, M. (María), Krumme, U. (Uwe), Landa, J. (Jorge), Mahé, K. (Kélig), Maxwell, David, McCormick, H. (Helen), Mirny, Zuzanna, Nunes, C. (Cristina), Ofridopoulou, Konstantina, Pérez-Rodríguez, A. (Alfonso), Piñeiro-Álvarez, C.G. (Carmen Gloria), Raid, Tiit, Raitaniemi, J. (Jari), Sapounidis, Argyris, Sauger, Carine, Smith, J., Stransky, C. (Christoph), Tomkiewicz, J., Torreele, E. (Els), Torres-Cutillas, P. (Pedro), Ulleweit, J. (Jens), van Damme, C.J.G. (Cindy), Visconti, V., Vxtale, F. (Francesca), Carbonara, P. (Pierluigi), Coad Davies, J., and van Damme, C.J.G. (Cindy)
Subjects: biological parameters, fish, graphs, training, Centro Oceanográfico de Santander, nutrient cycles, gloria, Pesquerías, quality assurance, natural resources, symbionts, data processing
Abstract: The main objective of the Working Group on Biological Parameters (WGBIOP) is to review the status, issues, developments, and quality assurance of biological parameters for use in assess-ments and management that are in line with the requirements of end-users. In this final year of the three-year term, WGBIOP operated under challenging circumstances due to COVID-19 measures. The initial action plan was replaced by a more flexible one, where online plenary and subgroup meetings were spread over the year with intersessional work to finalize the proposed deliverables. WGBIOP continued the review of past exchanges and workshops under the remit of the working group. Since 2019, these calibrations on age, maturity, and larvae identification have been carried out in SmartDots, an online platform for sharing images and facilitating the reading of otoliths, staging of gonads, and identification of early life stages. Developments are underway to include an improved calculation of modal age and error matrices in the SmartDots standard report. WGBIOP investigated ways to incorporate error matrices into assessments and studied the effect of this inclusion together with stock assessors. Requests for new exchanges and workshops were reviewed, with a focus on stocks to be bench-marked in the coming years. Issue lists were scrutinized, problems identified, and information provided to stock coordinators via regular channels and through the Stock Identification Data-base (SID). Despite close cooperation with stock assessors and continued efforts, it has not been possible to further streamline the WGBIOP workflow with the benchmark process. This will be addressed with the Advisory Committee. The need for validation studies was stressed by the repeated low levels of agreement between readers of some stocks and recurring issues and recommendations to WGBIOP. Lack of resources is the main obstacle. As a first step for measures to prioritize validation studies, WGBIOP iden-tified precision, trueness, and feasibility of validation methods (as well as the urgency for the assessment). WGBIOP continued investigations into new life-history parameters for integrated assessment and advice in cooperation with end-users (Working Group on Integrative, Physical-biological and Ecosystem Modelling-WGIPEM and Regional Coordination Groups-RCGs). This included a standardization and quality assurance action plan for stomach sampling. Efforts have also been taken to streamline data and workflows across databases and groups. A step has been taken in the standardization of quality assurance procedures at the regional level. Institute-level overviews of methods and quality assurance protocols used for ageing and maturity are now available. Also, a new method for quality grading was developed, tested, and implemented in SmartDots.
Published: 2020

42. Phenotype and genotype of 87 patients with Mowat–Wilson syndrome and recommendations for care

Author: Ivanovski, I. (Ivan), Djuric, O. (Olivera), Caraffi, S.G. (Stefano Giuseppe), Santodirocco, D. (Daniela), Pollazzon, M. (Marzia), Rosato, S. (Simonetta), Cordelli, D.M. (Duccio M.), Abdalla, E. (Ebtesam), Accorsi, P. (Patrizia), Adam, M.P. (Margaret), Ajmone, P.F. (Paola Francesca), Badura-Stronka, M. (Magdalena), Baldo, C. (Chiara), Baldi, M. (Maddalena), Bayat, A. (Allan), Bigoni, S. (Stefania), Bonvicini, F. (Federico), Breckpot, J. (Jeroen), Callewaert, L., Cocchi, G. (Guido), Cuturilo, G. (Goran), De Brasi, D. (Daniele), Devriendt, K. (Koenraad), Dinulos, M.B. (Mary Beth), Hjortshøj, T.D. (Tina Duelund), Epifanio, R. (Roberta), Faravelli, F. (Francesca), Fiumara, A. (Agata), Formisano, D. (Debora), Giordano, L. (Lucio), Grasso, M. (Marina), Grønborg, S. (Sabine), Iodice, A. (Alessandro), Iughetti, L. (Lorenzo), Kuburovic, V. (Vladimir), Kutkowska-Kazmierczak, A. (Anna), Lacombe, D. (Didier), Lo Rizzo, C. (Caterina), Luchetti, A. (Anna), Malbora, B. (Baris), Mammi, I. (Isabella), Mari, F. (Francesca), Montorsi, G. (Giulia), Moutton, S. (Sebastien), Møller, R.S. (Rikke), Muschke, P. (Petra), Nielsen, J.E.K. (Jens Erik Klint), Obersztyn, E. (Ewa), Pantaleoni, C. (Chiara), Pellicciari, A. (Alessandro), Pisanti, M.A. (Maria Antonietta), Prpic, I. (Igor), Poch-Olive, M.L. (Maria Luisa), Raviglione, F. (Federico), Renieri, A. (Alessandra), Ricci, E. (Emilia), Rivieri, F. (Francesca), Santen, G.W.E. (Gijs), Savasta, S. (Salvatore), Scarano, G. (Gioacchino), Schanze, I. (Ina), Selicorni, A. (Angelo), Silengo, M.C., Smigiel, R. (Robert), Spaccini, L. (Luigina), Sorge, G. (Giovanni), Szczaluba, K. (Krzysztof), Tarani, L. (Luigi), Tone, L.G. (Luis Gonzaga), Toutain, A. (Annick), Trimouille, A. (Aurelien), Valera, E.T. (Elvis Terci), Vergano, S.S. (Samantha Schrier), Zanotta, N. (Nicoletta), Zenker, M. (Martin), Conidi, A. (Andrea), Zollino, M., Rauch, A., Zweier, C. (Christiane), Garavelli, L. (Livia), Ivanovski, I. (Ivan), Djuric, O. (Olivera), Caraffi, S.G. (Stefano Giuseppe), Santodirocco, D. (Daniela), Pollazzon, M. (Marzia), Rosato, S. (Simonetta), Cordelli, D.M. (Duccio M.), Abdalla, E. (Ebtesam), Accorsi, P. (Patrizia), Adam, M.P. (Margaret), Ajmone, P.F. (Paola Francesca), Badura-Stronka, M. (Magdalena), Baldo, C. (Chiara), Baldi, M. (Maddalena), Bayat, A. (Allan), Bigoni, S. (Stefania), Bonvicini, F. (Federico), Breckpot, J. (Jeroen), Callewaert, L., Cocchi, G. (Guido), Cuturilo, G. (Goran), De Brasi, D. (Daniele), Devriendt, K. (Koenraad), Dinulos, M.B. (Mary Beth), Hjortshøj, T.D. (Tina Duelund), Epifanio, R. (Roberta), Faravelli, F. (Francesca), Fiumara, A. (Agata), Formisano, D. (Debora), Giordano, L. (Lucio), Grasso, M. (Marina), Grønborg, S. (Sabine), Iodice, A. (Alessandro), Iughetti, L. (Lorenzo), Kuburovic, V. (Vladimir), Kutkowska-Kazmierczak, A. (Anna), Lacombe, D. (Didier), Lo Rizzo, C. (Caterina), Luchetti, A. (Anna), Malbora, B. (Baris), Mammi, I. (Isabella), Mari, F. (Francesca), Montorsi, G. (Giulia), Moutton, S. (Sebastien), Møller, R.S. (Rikke), Muschke, P. (Petra), Nielsen, J.E.K. (Jens Erik Klint), Obersztyn, E. (Ewa), Pantaleoni, C. (Chiara), Pellicciari, A. (Alessandro), Pisanti, M.A. (Maria Antonietta), Prpic, I. (Igor), Poch-Olive, M.L. (Maria Luisa), Raviglione, F. (Federico), Renieri, A. (Alessandra), Ricci, E. (Emilia), Rivieri, F. (Francesca), Santen, G.W.E. (Gijs), Savasta, S. (Salvatore), Scarano, G. (Gioacchino), Schanze, I. (Ina), Selicorni, A. (Angelo), Silengo, M.C., Smigiel, R. (Robert), Spaccini, L. (Luigina), Sorge, G. (Giovanni), Szczaluba, K. (Krzysztof), Tarani, L. (Luigi), Tone, L.G. (Luis Gonzaga), Toutain, A. (Annick), Trimouille, A. (Aurelien), Valera, E.T. (Elvis Terci), Vergano, S.S. (Samantha Schrier), Zanotta, N. (Nicoletta), Zenker, M. (Martin), Conidi, A. (Andrea), Zollino, M., Rauch, A., Zweier, C. (Christiane), and Garavelli, L. (Livia)
Abstract: Purpose: Mowat–Wilson syndrome (MWS) is a rare intellectual disability/multiple congenital anomalies syndrome caused by heterozygous mutation of the ZEB2 gene. It is generally underestimated because its rarity and phenotypic variability sometimes make it difficult to recognize. Here, we aimed to better delineate the phenotype, natural history, and genotype–phenotype correlations of MWS. Methods: In a collaborative study, we analyzed clinical data for 87 patients with molecularly confirmed diagnosis. We described the prevalence of all clinical aspects, including attainment of neurodevelopmental milestones, and compared the data with the various types of underlying ZEB2 pathogenic variations. Results: All anthropometric, somatic, and behavioral features reported here outline a variable but highly consistent phenotype. By presenting the most comprehensive evaluatio
Published: 2018
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43. Migraine and cluster headache - the common link

Author: Vollesen, A.L. (Anne Luise), Benemei, S. (Silvia), Cortese, F. (Francesca), Labastida-Ramirez, A. (Alejandro), Marchese, F. (Francesca), Pellesi, L. (Lanfranco), Romoli, M. (Michele), Ashina, M. (Messoud), Lampl, C. (Christian), Vollesen, A.L. (Anne Luise), Benemei, S. (Silvia), Cortese, F. (Francesca), Labastida-Ramirez, A. (Alejandro), Marchese, F. (Francesca), Pellesi, L. (Lanfranco), Romoli, M. (Michele), Ashina, M. (Messoud), and Lampl, C. (Christian)
Abstract: Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
Published: 2018
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44. The role of external beam radiation therapy for post prostatectomy stress urinary incontinence in transobturator male sling outcomes. A multicentric experience

Author: V. Li Marzi, Andrea Liaci, M. Di Camillo, Simone Morselli, Cinzia Traversi, Aldo Tosto, M. Gerolamo, R. Fantechi, Sergio Serni, Luca Gemma, Ramona Baldesi, and F. Francesca
Subjects: medicine.medical_specialty, business.industry, Male sling, Urology, External beam radiation, Urinary incontinence, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, medicine, medicine.symptom, business, Post prostatectomy
Published: 2020

45. P1446Cavo-tricuspid atrial flutter catheter ablation with a real zero fluoroscopic approach

Author: Serafina Valente, Claudia Baiocchi, Sergio Mondillo, Filippo Lamberti, F F Francesca Falciani, Nicolò Sisti, and Antonio Santoro
Subjects: medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, medicine.medical_treatment, medicine, Zero (complex analysis), Cardiology, Catheter ablation, Cardiology and Cardiovascular Medicine, medicine.disease, business, Atrial flutter
Abstract: Funding Acknowledgements none Background Catheter ablation(CA)is the first-line therapy of cavo-tricuspid isthmus(CTI)atrial flutter. Sometimes an inversion of ablation catheter is necessary to obtain a complete bidirectional line block. Purpose.The aim of this study was to describe this CA approach using electro-anatomical mapping(EAM)system with a zero-fluoroscopy(ZF)approach.Methods.Ninety-four patients that performed CA of CTI were retrospectively enrolled since 2017 to 2019.The studied population were divided in two groups.Group1(44patients) was composed of patients who underwent CA using ablation catheter without shaft visualization catheter(NSVC)on EAM.Group2(50patients)was composed of patients who underwent CA using ablation catheter with a shaft visualization(SVC). The catheter was looped at the Eustachian ridge after 200 seconds of RF without elimination of local electrogram. Results.ZF CTI ablation was obtained in all patients of group 2 without fluoroscopy use.In six patients of group 1, the catheter inversion was used to obtain a complete CTI block.In NSVC group, the catheter inversion was obtained using fluoroscopy to avoid damages during loop of catheter ablation.In overall population studied SVC had a linear correlation with ZF approach(β=0.629;p Conclusions.A real ZF catheter ablation of atrial flutter is safe and feasible.The use of SVC could improve the reproducibility of a successful zero-fluoroscopy CA.The visualization of the shaft’s catheter permit to invert the catheter safely to overcome anatomic complexity of some CTI without fluoroscopy use. detailed results Detailed results Group 1(44 CA) Group 2(50 CA) p value Procedure time (min) 83.4 ± 22.4 80.2 ± 34.7 NS AFL at begin CA (n.) 36 23 FT (min) 9.1 ± 9.8 0 ± 0 < 0.001 PWRF (W) 32 ±2.5 33.6 ±2.2 NS CA line length (mm) 28.1 ± 4.1 27.9 ± 5.5 NS Total RF (min) 27.8 ± 6.3 13.6 ± 7.2 < 0.01 SR during RF 35 23 Conductional block after 30 min 44 50 NS 6 months recurrences 1 1 NS AFL: atrial flutter; FT: fluoroscopy time; PWRF: power radiofrequencies; CA line length: length of line of radiofrequencies; RF: radiofrequencies; SR: sinus rhythm. Detailed results. Abstract Figure.
Published: 2020

46. Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Author: Andelic, N. (Nada), Røe, C. (Cecilie), Brunborg, C. (Cathrine), Zeldovich, M. (Marina), Løvstad, M. (Marianne), Løke, D. (Daniel), Borgen, I.M. (Ida M.), Voormolen, D.C. (Daphne), Howe, E.I. (Emilie I.), Forslund, M.V. (Marit V.), Dahl, H.M. (Hilde M.), Von Steinbuechel, N. (Nicole), Åkerlund, C. (Cecilia), Amrein, K. (Krisztina), Andreassen, L. (Lasse), Anke, A. (Audny), Antoni, A. (Anna), Audibert, G. (Gérard), Azouvi, P. (Philippe), Azzolini, M.L. (Maria Luisa), Bartels, R.H.M.A. (Ronald), Barzo, P. (P.), Beauvais, R. (Romuald), Beer, R. (Ronny), Bellander, B.-M. (Bo-Michael), Belli, A. (Antonio), Benali, H. (Habib), Berardino, M. (Maurizio), Beretta, L. (Luigi), Blaabjerg, M. (Morten), Bragge, P. (Peter), Brazinova, A. (Alexandra), Brinck, V. (Vibeke), Brooker, J. (Joanne), Brorsson, C. (Camilla), Buki, A. (Andras), Bullinger, M. (Monika), Cabeleira, M. (Manuel), Caccioppola, A. (Alessio), Calappi, E. (Emiliana), Calvi, M.R. (Maria Rosa), Cameron, P. (Peter), Lozano, G.C. (Guillermo Carbayo), Carbonara, M. (Marco), Cavallo, S. (Simona), Chevallard, G. (Giorgio), Chieregato, A. (Arturo), Citerio, G. (Giuseppe), Ceyisakar, I.E. (Iris), Clusmann, H. (Hans), Coburn, M. (Mark), Coles, J.P. (Jonathan P.), Cooper, J.D. (Jamie D), Correia, M. (Marta), Covic, A. (Amra), Curry, N. (Nicola), Czeiter, E. (Endre), Czosnyka, M. (Marek), Dahyot-Fizelier, C. (Claire), Dark, P. (Paul), Dawes, H. (Helen), Keyser, V. (Véronique), Degos, V. (Vincent), Corte, F.D. (Francesco Della), Boogert, H. (Hugo), Depreitere, B. (Bart), Đilvesi, Đ. (Đula), Dixit, A. (Abhishek), Donoghue, E. (Emma), Dreier, J.P. (Jens), Dulière, G.-L. (Guy -Loup), Ercole, A. (Ari), Esser, P. (Patrick), Ezer, E. (Erzsébet), Fabricius, M. (Martin), Feigin, V.L. (Valery L), Foks, K. (Kelly), Frisvold, S.K. (Shirin Kordasti), Furmanov, A. (Alex), Gagliardo, P. (Pablo), Galanaud, D. (Damien), Gantner, D. (Dashiell), Gao, G. (Guoyi), George, P. (Pradeep), Ghuysen, A. (Alexandre), Giga, L. (Lelde), Glocker, B. (Ben), Golubovic, J. (Jagoš), Gomez, P.A. (Pedro A), Gratz, J. (Johannes), Gravesteijn, B. (Benjamin), Grossi, F. (Francesca), Gruen, R.L. (Russell), Gupta, D. (Deepak), Haagsma, J.A. (Juanita), Haitsma, I. (Iain), Helbok, R. (Raimund), Helseth, E. (Eirik), Horton, L. (Lindsay), Huijben, J. (Jilske), Hutchinson, P.J. (Peter J.), Jacobs, B.C. (Bart), Jankowski, S. (Stefan), Jarrett, M. (Mike), Jiang, J.-Y. (Ji-Yao), Johnson, F. (Faye), Jones, K.M. (Kelly M.), Karan, M. (Mladen), Kolias, A.G. (Angelos G.), Kompanje, E.J.O. (Erwin), Kondziella, D. (Daniel), Koraropoulos, E. (Evgenios), Koskinen, L.-O. (Lars-Owe), Kovács, N. (Noémi), Kowark, A. (Ana), Lagares, A. (Alfonso), Lanyon, L. (Linda), Laureys, S. (Steven), Lecky, F.E. (Fiona), Ledoux, D. (Didier), Lefering, R., Legrand, V. (Valerie), Lejeune, A. (Aurelie), Levi, L. (Leon), Lightfoot, R. (Roger), Lingsma, H.F. (Hester), Maas, A.I.R. (Andrew), Castaño-León, A.M. (Ana M), Maegele, M. (Marc), Majdan, M. (Marek), Manara, A. (Alex), Manley, G. (Geoffrey), Martino, C. (Costanza), Maréchal, H. (Hugues), Mattern, J. (Julia), McMahon, C. (Catherine), Melegh, B. (Béla), Menon, D.K. (David ), Menovsky, T. (Tomas), Mikolic, A. (Ana), Misset, B. (Benoit), Muraleedharan, V. (Visakh), Murray, L. (Lynnette), Negru, A. (Ancuta), Nelson, D. (David), Newcombe, V.F. (Virginia F.), Nieboer, D. (Daan), Nyirádi, J. (József), Olubukola, O. (Otesile), Oresic, M. (Matej), Ortolano, F. (Fabrizio), Palotie, A. (Aarno), Parizel, P.M., Payen, J.-F. (Jean-François), Perera, N. (Natascha), Perlbarg, V. (Vincent), Persona, P. (Paolo), Peul, W.C. (Wilco), Piippo-Karjalainen, A. (Anna), Pirinen, M. (Matti), Ples, H. (Horia), Polinder, S. (Suzanne), Pomposo, I. (Inigo), Posti, J.P. (Jussi P), Puybasset, L. (Louis), Radoi, A. (Andreea), Ragauskas, A. (Arminas), Raj, R. (Rahul), Rambadagalla, M. (Malinka), Rhodes, J.K.J. (Jonathan K.J.), Richardson, S. (Sylvia), Richter, S. (Sophie), Ripatti, S. (Samuli), Rocka, S. (Saulius), Roe, C. (Cecilie), Roise, O. (Olav), Rosand, J. (Jonathan), Rosenfeld, J.V. (Jeffrey V), Rosenlund, C. (Christina), Rosenthal, G. (Guy), Rossaint, R. (Rolf), Rossi, S. (Sandra), Rueckert, D. (Daniel), Rusnák, M. (Martin), Sahuquillo, J. (Juan), Sakowitz, O. (Oliver), Sanchez-Porras, R. (Renan), Sandor, J. (Janos), Schäfer, N. (Nadine), Schmidt, S. (Silke), Schoechl, H. (Herbert), Schoonman, G.G. (Guus), Schou, R. (Rico), Schwendenwein, E. (Elisabeth), Sewalt, C. (Charlie), Skandsen, T. (Toril), Smielewski, P. (Peter), Sorinola, A. (Abayomi), Stamatakis, E. (Emmanuel), Stanworth, S. (Simon), Stevens, R. (Robert), Stewart, W. (William), Steyerberg, E.W. (Ewout), Stocchetti, N. (Nino), Sundström, N. (Nina), Synnot, A. (Anneliese), Takala, R. (Riikka), Tamás, V. (Viktória), Tamosuitis, T. (Tomas), Taylor, M.S. (Mark Steven), Ao, B.T. (Braden Te), Tenovuo, O. (Olli), Theadom, A. (Alice), Thomas, M. (Matt), Tibboel, D. (Dick), Timmers, M. (Marjolein), Tolias, C.M. (Christos M.), Trapani, T. (Tony), Maria Tudora, C. (Cristina), Vajkoczy, P. (Peter), Vallance, S. (Shirley), Valeinis, E. (Egils), Vámos, Z. (Zoltán), Jagt, M. (Mathieu), Steen, G. (Gregory), Naalt, J. (Joukje), Jeroen, T.J.M.D. (T.J.M. van Dijck), Essen, T.A. (Thomas A.), Hecke, W. (Wim), Heugten, C. (Caroline), Praag, D. (Dominique), Vyvere, T. (Thijs), RoelWijk, P.J. (P. J.), Vargiolu, A. (Alessia), Vega, E. (Emmanuel), Velt, K. (Kimberley), Verheyden, J. (Jan), Vespa, P.M. (Paul M), Vik, A. (Anne), Vilcinis, R. (Rimantas), Volovici, V. (Victor), Steinbüchel, N. (Nicole), Voormolen, D. (Daphne), Vulekovic, P. (Peter), Wang, K.K.W. (Kevin), Wiegers, E. (Eveline), Williams, G. (Guy), Wilson, L. (Lindsay), Winzeck, S. (Stefan), Wolf, S. (Stefan), Yang, Z. (Zhihui), Ylén, P. (Peter), Younsi, A. (Alexander), Zeiler, F.A. (Frederick A.), Zelinkova, V. (Veronika), Ziverte, A. (Agate), Zoerle, T. (Tommaso), Andelic, N. (Nada), Røe, C. (Cecilie), Brunborg, C. (Cathrine), Zeldovich, M. (Marina), Løvstad, M. (Marianne), Løke, D. (Daniel), Borgen, I.M. (Ida M.), Voormolen, D.C. (Daphne), Howe, E.I. (Emilie I.), Forslund, M.V. (Marit V.), Dahl, H.M. (Hilde M.), Von Steinbuechel, N. (Nicole), Åkerlund, C. (Cecilia), Amrein, K. (Krisztina), Andreassen, L. (Lasse), Anke, A. (Audny), Antoni, A. (Anna), Audibert, G. (Gérard), Azouvi, P. (Philippe), Azzolini, M.L. (Maria Luisa), Bartels, R.H.M.A. (Ronald), Barzo, P. (P.), Beauvais, R. (Romuald), Beer, R. (Ronny), Bellander, B.-M. (Bo-Michael), Belli, A. (Antonio), Benali, H. (Habib), Berardino, M. (Maurizio), Beretta, L. (Luigi), Blaabjerg, M. (Morten), Bragge, P. (Peter), Brazinova, A. (Alexandra), Brinck, V. (Vibeke), Brooker, J. (Joanne), Brorsson, C. (Camilla), Buki, A. (Andras), Bullinger, M. (Monika), Cabeleira, M. (Manuel), Caccioppola, A. (Alessio), Calappi, E. (Emiliana), Calvi, M.R. (Maria Rosa), Cameron, P. (Peter), Lozano, G.C. (Guillermo Carbayo), Carbonara, M. (Marco), Cavallo, S. (Simona), Chevallard, G. (Giorgio), Chieregato, A. (Arturo), Citerio, G. (Giuseppe), Ceyisakar, I.E. (Iris), Clusmann, H. (Hans), Coburn, M. (Mark), Coles, J.P. (Jonathan P.), Cooper, J.D. (Jamie D), Correia, M. (Marta), Covic, A. (Amra), Curry, N. (Nicola), Czeiter, E. (Endre), Czosnyka, M. (Marek), Dahyot-Fizelier, C. (Claire), Dark, P. (Paul), Dawes, H. (Helen), Keyser, V. (Véronique), Degos, V. (Vincent), Corte, F.D. (Francesco Della), Boogert, H. (Hugo), Depreitere, B. (Bart), Đilvesi, Đ. (Đula), Dixit, A. (Abhishek), Donoghue, E. (Emma), Dreier, J.P. (Jens), Dulière, G.-L. (Guy -Loup), Ercole, A. (Ari), Esser, P. (Patrick), Ezer, E. (Erzsébet), Fabricius, M. (Martin), Feigin, V.L. (Valery L), Foks, K. (Kelly), Frisvold, S.K. (Shirin Kordasti), Furmanov, A. (Alex), Gagliardo, P. (Pablo), Galanaud, D. (Damien), Gantner, D. (Dashiell), Gao, G. (Guoyi), George, P. (Pradeep), Ghuysen, A. (Alexandre), Giga, L. (Lelde), Glocker, B. (Ben), Golubovic, J. (Jagoš), Gomez, P.A. (Pedro A), Gratz, J. (Johannes), Gravesteijn, B. (Benjamin), Grossi, F. (Francesca), Gruen, R.L. (Russell), Gupta, D. (Deepak), Haagsma, J.A. (Juanita), Haitsma, I. (Iain), Helbok, R. (Raimund), Helseth, E. (Eirik), Horton, L. (Lindsay), Huijben, J. (Jilske), Hutchinson, P.J. (Peter J.), Jacobs, B.C. (Bart), Jankowski, S. (Stefan), Jarrett, M. (Mike), Jiang, J.-Y. (Ji-Yao), Johnson, F. (Faye), Jones, K.M. (Kelly M.), Karan, M. (Mladen), Kolias, A.G. (Angelos G.), Kompanje, E.J.O. (Erwin), Kondziella, D. (Daniel), Koraropoulos, E. (Evgenios), Koskinen, L.-O. (Lars-Owe), Kovács, N. (Noémi), Kowark, A. (Ana), Lagares, A. (Alfonso), Lanyon, L. (Linda), Laureys, S. (Steven), Lecky, F.E. (Fiona), Ledoux, D. (Didier), Lefering, R., Legrand, V. (Valerie), Lejeune, A. (Aurelie), Levi, L. (Leon), Lightfoot, R. (Roger), Lingsma, H.F. (Hester), Maas, A.I.R. (Andrew), Castaño-León, A.M. (Ana M), Maegele, M. (Marc), Majdan, M. (Marek), Manara, A. (Alex), Manley, G. (Geoffrey), Martino, C. (Costanza), Maréchal, H. (Hugues), Mattern, J. (Julia), McMahon, C. (Catherine), Melegh, B. (Béla), Menon, D.K. (David ), Menovsky, T. (Tomas), Mikolic, A. (Ana), Misset, B. (Benoit), Muraleedharan, V. (Visakh), Murray, L. (Lynnette), Negru, A. (Ancuta), Nelson, D. (David), Newcombe, V.F. (Virginia F.), Nieboer, D. (Daan), Nyirádi, J. (József), Olubukola, O. (Otesile), Oresic, M. (Matej), Ortolano, F. (Fabrizio), Palotie, A. (Aarno), Parizel, P.M., Payen, J.-F. (Jean-François), Perera, N. (Natascha), Perlbarg, V. (Vincent), Persona, P. (Paolo), Peul, W.C. (Wilco), Piippo-Karjalainen, A. (Anna), Pirinen, M. (Matti), Ples, H. (Horia), Polinder, S. (Suzanne), Pomposo, I. (Inigo), Posti, J.P. (Jussi P), Puybasset, L. (Louis), Radoi, A. (Andreea), Ragauskas, A. (Arminas), Raj, R. (Rahul), Rambadagalla, M. (Malinka), Rhodes, J.K.J. (Jonathan K.J.), Richardson, S. (Sylvia), Richter, S. (Sophie), Ripatti, S. (Samuli), Rocka, S. (Saulius), Roe, C. (Cecilie), Roise, O. (Olav), Rosand, J. (Jonathan), Rosenfeld, J.V. (Jeffrey V), Rosenlund, C. (Christina), Rosenthal, G. (Guy), Rossaint, R. (Rolf), Rossi, S. (Sandra), Rueckert, D. (Daniel), Rusnák, M. (Martin), Sahuquillo, J. (Juan), Sakowitz, O. (Oliver), Sanchez-Porras, R. (Renan), Sandor, J. (Janos), Schäfer, N. (Nadine), Schmidt, S. (Silke), Schoechl, H. (Herbert), Schoonman, G.G. (Guus), Schou, R. (Rico), Schwendenwein, E. (Elisabeth), Sewalt, C. (Charlie), Skandsen, T. (Toril), Smielewski, P. (Peter), Sorinola, A. (Abayomi), Stamatakis, E. (Emmanuel), Stanworth, S. (Simon), Stevens, R. (Robert), Stewart, W. (William), Steyerberg, E.W. (Ewout), Stocchetti, N. (Nino), Sundström, N. (Nina), Synnot, A. (Anneliese), Takala, R. (Riikka), Tamás, V. (Viktória), Tamosuitis, T. (Tomas), Taylor, M.S. (Mark Steven), Ao, B.T. (Braden Te), Tenovuo, O. (Olli), Theadom, A. (Alice), Thomas, M. (Matt), Tibboel, D. (Dick), Timmers, M. (Marjolein), Tolias, C.M. (Christos M.), Trapani, T. (Tony), Maria Tudora, C. (Cristina), Vajkoczy, P. (Peter), Vallance, S. (Shirley), Valeinis, E. (Egils), Vámos, Z. (Zoltán), Jagt, M. (Mathieu), Steen, G. (Gregory), Naalt, J. (Joukje), Jeroen, T.J.M.D. (T.J.M. van Dijck), Essen, T.A. (Thomas A.), Hecke, W. (Wim), Heugten, C. (Caroline), Praag, D. (Dominique), Vyvere, T. (Thijs), RoelWijk, P.J. (P. J.), Vargiolu, A. (Alessia), Vega, E. (Emmanuel), Velt, K. (Kimberley), Verheyden, J. (Jan), Vespa, P.M. (Paul M), Vik, A. (Anne), Vilcinis, R. (Rimantas), Volovici, V. (Victor), Steinbüchel, N. (Nicole), Voormolen, D. (Daphne), Vulekovic, P. (Peter), Wang, K.K.W. (Kevin), Wiegers, E. (Eveline), Williams, G. (Guy), Wilson, L. (Lindsay), Winzeck, S. (Stefan), Wolf, S. (Stefan), Yang, Z. (Zhihui), Ylén, P. (Peter), Younsi, A. (Alexander), Zeiler, F.A. (Frederick A.), Zelinkova, V. (Veronika), Ziverte, A. (Agate), and Zoerle, T. (Tommaso)
Abstract: Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subje
Published: 2020
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47. Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome (Pituitary, (2020), 10.1007/s11102-020-01103-6)

Author: Geer, E.B. (Eliza B.), Salvatori, R. (Roberto), Elenkova, A. (Atanaska), Fleseriu, M. (Maria), Pivonello, R. (Rosario), Witek, P. (Przemyslaw), Feelders, R.A. (Richard), Bex, M. (Marie), Borresen, S.W. (Stina W.), Puglisi, S. (Soraya), Biller, B.M.K., Cohen, F. (Fredric), Pecori Giraldi, F. (Francesca), Geer, E.B. (Eliza B.), Salvatori, R. (Roberto), Elenkova, A. (Atanaska), Fleseriu, M. (Maria), Pivonello, R. (Rosario), Witek, P. (Przemyslaw), Feelders, R.A. (Richard), Bex, M. (Marie), Borresen, S.W. (Stina W.), Puglisi, S. (Soraya), Biller, B.M.K., Cohen, F. (Fredric), and Pecori Giraldi, F. (Francesca)
Abstract: The original version of the article unfortunately contained an error in the first name and the surname of one of the authors in the author group. The last author name was incorrectly published as ‘F. Pecori Giraldi’ and the corrected name is ‘Francesca Pecori Giraldi’ (First name: Francesca; Surname: Pecori Giraldi).
Published: 2020
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48. Somatic TARDBP variants as a cause of semantic dementia

Author: Rooij, J.G.J. (Jeroen) van, Mol, M.O., Melhem, S. (Shamiram), van der Wal, P. (Pelle), Arp, P.P. (Pascal), Paron, F. (Francesca), Donker Kaat, L. (Laura), Seelaar, H. (Harro), Miedema, S.S.M. (Suzanne S M), Oshima, T. (Takuya), Eggen, B.J.L. (Bart J L), Uitterlinden, A.G. (André), van Meurs, J. (Joyce), Kesteren, R.E. (Ronald) van, Smit, A.B. (August), Buratti, E. (Emanuele), Swieten, J.C. (John) van, Rooij, J.G.J. (Jeroen) van, Mol, M.O., Melhem, S. (Shamiram), van der Wal, P. (Pelle), Arp, P.P. (Pascal), Paron, F. (Francesca), Donker Kaat, L. (Laura), Seelaar, H. (Harro), Miedema, S.S.M. (Suzanne S M), Oshima, T. (Takuya), Eggen, B.J.L. (Bart J L), Uitterlinden, A.G. (André), van Meurs, J. (Joyce), Kesteren, R.E. (Ronald) van, Smit, A.B. (August), Buratti, E. (Emanuele), and Swieten, J.C. (John) van
Abstract: The aetiology of late-onset neurodegenerative diseases is largely unknown. Here we investigated whether de novo somatic variants for semantic dementia can be detected, thereby arguing for a more general role of somatic variants in
Published: 2020
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49. Informed consent procedures in patients with an acute inability to provide informed consent

Author: van Wijk, R.P.J. (Roel P.J.), van Dijck, J.T.J.M. (Jeroen T.J.M.), Timmers, M. (Marjolein), Veen, E. (Ernest) van, Citerio, G. (Giuseppe), Lingsma, H.F. (Hester), Maas, A.I.R. (Andrew), Menon, D.K. (David K.), Peul, W.C. (Wilco C.), Stocchetti, N. (Nino), Kompanje, E.J.O. (Erwin), Åkerlund, C. (Cecilia), Amrein, K. (Krisztina), Andelic, N. (Nada), Andreassen, L. (Lasse), Anke, A. (Audny), Antoni, A. (Anna), Audibert, G. (Gérard), Azouvi, P. (Philippe), Azzolini, M.L. (Maria Luisa), Bartels, R.H.M.A. (Ronald), Barzo, P. (P.), Beauvais, R. (Romuald), Beer, R. (Ronny), Bellander, B.-M. (Bo-Michael), Belli, A. (Antonio), Benali, H. (Habib), Berardino, M. (Maurizio), Beretta, L. (Luigi), Blaabjerg, M. (Morten), Bragge, P. (Peter), Brazinova, A. (Alexandra), Brinck, V. (Vibeke), Brooker, J. (Joanne), Brorsson, C. (Camilla), Buki, A. (Andras), Bullinger, M. (Monika), Cabeleira, M. (Manuel), Caccioppola, A. (Alessio), Calappi, E. (Emiliana), Calvi, M.R. (Maria Rosa), Cameron, P. (Peter), Lozano, G.C. (Guillermo Carbayo), Carbonara, M. (Marco), Cavallo, S. (Simona), Chevallard, G. (Giorgio), Chieregato, A. (Arturo), Ceyisakar, I.E. (Iris), Coburn, M. (Mark), Coles, J.P. (Jonathan P.), Cooper, J.D. (Jamie D.), Correia, M. (Marta), Covic, A. (Amra), Curry, N. (Nicola), Czeiter, E. (Endre), Czosnyka, M. (Marek), Dahyot-Fizelier, C. (Claire), Dark, P. (Paul), Dawes, H. (Helen), De Keyser, V. (Véronique), Degos, V. (Vincent), Corte, F.D. (Francesco Della), den Boogert, H. (Hugo), Depreitere, B. (Bart), Đilvesi, Đ. (Đula), Dixit, A. (Abhishek), Donoghue, E. (Emma), Dreier, J.P. (Jens), Dulière, G.-L. (Guy-Loup), Ercole, A. (Ari), Esser, P. (Patrick), Ezer, E. (Erzsébet), Fabricius, M. (Martin), Feigin, V.L. (Valery L.), Foks, K.A. (Kelly), Frisvold, S.K. (Shirin Kordasti), Furmanov, A. (Alex), Gagliardo, P. (Pablo), Galanaud, D. (Damien), Gantner, D. (Dashiell), Gao, G. (Guoyi), George, P. (Pradeep), Ghuysen, A. (Alexandre), Giga, L. (Lelde), Glocker, B. (Ben), Golubovic, J. (Jagoš), Gomez, P.A. (Pedro A.), Gratz, J. (Johannes), Gravesteijn, B.Y. (Benjamin), Grossi, F. (Francesca), Gruen, R.L. (Russell), Gupta, D. (Deepak), Haagsma, J.A. (Juanita), Haitsma, I. (Iain), Helbok, R. (Raimund), Helseth, E. (Eirik), Horton, L. (Lindsay), Huijben, A.L.C.J.R.M. (Jilske), Hutchinson, P.J. (Peter J.), Jacobs, B.C. (Bart), Jankowski, S. (Stefan), Jarrett, M. (Mike), Jiang, J.-Y. (Ji-Yao), Johnson, F. (Faye), Jones, K.M. (Kelly M.), Karan, M. (Mladen), Kolias, A.G. (Angelos G.), Kondziella, D. (Daniel), Koraropoulos, E. (Evgenios), Koskinen, L.-O. (Lars-Owe), Kovács, N. (Noémi), Kowark, A. (Ana), Lagares, A. (Alfonso), Lanyon, L. (Linda), Laureys, S. (Steven), Lecky, F.E. (Fiona), Ledoux, D. (Didier), Lefering, R., Legrand, V. (Valerie), Lejeune, A. (Aurelie), Levi, L. (Leon), Lightfoot, R. (Roger), Castaño-León, A.M. (Ana M.), Maegele, M. (Marc), Majdan, M. (Marek), Manara, A. (Alex), Manley, G. (Geoffrey), Martino, C. (Costanza), Maréchal, H. (Hugues), Mattern, J. (Julia), McMahon, C. (Catherine), Melegh, B. (Béla), Menon, D.K. (David ), Menovsky, T. (Tomas), Misset, B. (Benoit), Mulazzi, D. (Davide), Muraleedharan, V. (Visakh), Murray, L. (Lynnette), Negru, A. (Ancuta), Nelson, D. (David), Newcombe, V.F. (Virginia F.), Nieboer, D. (Daan), Nyirádi, J. (József), Olubukola, O. (Otesile), Oresic, M. (Matej), Ortolano, F. (Fabrizio), Palotie, A. (Aarno), Parizel, P.M., Payen, J.-F. (Jean-François), Perera, N. (Natascha), Perlbarg, V. (Vincent), Persona, P. (Paolo), Peul, W.C. (Wilco), Piippo-Karjalainen, A. (Anna), Pirinen, M. (Matti), Ples, H. (Horia), Polinder, S. (Suzanne), Pomposo, I. (Inigo), Posti, J.P. (Jussi P.), Puybasset, L. (Louis), Radoi, A. (Andreea), Ragauskas, A. (Arminas), Raj, R. (Rahul), Rambadagalla, M. (Malinka), Rhodes, J.K.J. (Jonathan K.J.), Richardson, S. (Sylvia), Richter, S. (Sophie), Ripatti, S. (Samuli), Rocka, S. (Saulius), Roe, C. (Cecilie), Roise, O. (Olav), Rosand, J. (Jonathan), Rosenfeld, J.V. (Jeffrey V.), Rosenlund, C. (Christina), Rosenthal, G. (Guy), Rossaint, R. (Rolf), Rossi, S. (Sandra), Rueckert, D. (Daniel), Rusnák, M. (Martin), Sahuquillo, J. (Juan), Sakowitz, O. (Oliver), Sanchez-Porras, R. (Renan), Sandor, J. (Janos), Schäfer, N. (Nadine), Schmidt, S. (Silke), Schoechl, H. (Herbert), Schoonman, G.G. (Guus), Schou, R. (Rico), Schwendenwein, E. (Elisabeth), Sewalt, C.A. (Charlie), Skandsen, T. (Toril), Smielewski, P. (Peter), Sorinola, A. (Abayomi), Stamatakis, E. (Emmanuel), Stanworth, S. (Simon), Stevens, R. (Robert), Stewart, W. (William), Steyerberg, E.W. (Ewout), Sundström, N. (Nina), Synnot, A. (Anneliese), Takala, R. (Riikka), Tamás, V. (Viktória), Tamosuitis, T. (Tomas), Taylor, M.S. (Mark Steven), Ao, B.T. (Braden Te), Tenovuo, O. (Olli), Theadom, A. (Alice), Thomas, M. (Matt), Tibboel, D. (Dick), Tolias, C.M. (Christos M.), Trapani, T. (Tony), Tudora, C.M. (Cristina Maria), Vajkoczy, P. (Peter), Vallance, S. (Shirley), Valeinis, E. (Egils), Vámos, Z. (Zoltán), Van der Steen, G. (Gregory), Naalt, J. (Joukje) van der, van Essen, T.A. (Thomas A.), Hecke, W. (Wim) van, van Heugten, C.M. (Caroline M.), Van Praag, D. (Dominique), Vyvere, T.V. (Thijs Vande), Vargiolu, A. (Alessia), Vega, E. (Emmanuel), Velt, K.B. (Kimberley), Verheyden, J. (Jan), Vespa, P.M. (Paul M.), Vik, A. (Anne), Vilcinis, R. (Rimantas), Volovici, V. (Victor), Von Steinbüchel, N. (Nicole), Voormolen, D.C. (Daphne), Vulekovic, P. (Peter), Wang, K.K.W. (Kevin), Wiegers-Groeneweg, E.J.A. (Eveline), Williams, G. (Guy), Wilson, L. (Lindsay), Winzeck, S. (Stefan), Wolf, S. (Stefan), Yang, Z. (Zhihui), Ylén, P. (Peter), Younsi, A. (Alexander), Zeiler, F.A. (Frederick A.), Zelinkova, V. (Veronika), Ziverte, A. (Agate), Zoerle, T. (Tommaso), van Wijk, R.P.J. (Roel P.J.), van Dijck, J.T.J.M. (Jeroen T.J.M.), Timmers, M. (Marjolein), Veen, E. (Ernest) van, Citerio, G. (Giuseppe), Lingsma, H.F. (Hester), Maas, A.I.R. (Andrew), Menon, D.K. (David K.), Peul, W.C. (Wilco C.), Stocchetti, N. (Nino), Kompanje, E.J.O. (Erwin), Åkerlund, C. (Cecilia), Amrein, K. (Krisztina), Andelic, N. (Nada), Andreassen, L. (Lasse), Anke, A. (Audny), Antoni, A. (Anna), Audibert, G. (Gérard), Azouvi, P. (Philippe), Azzolini, M.L. (Maria Luisa), Bartels, R.H.M.A. (Ronald), Barzo, P. (P.), Beauvais, R. (Romuald), Beer, R. (Ronny), Bellander, B.-M. (Bo-Michael), Belli, A. (Antonio), Benali, H. (Habib), Berardino, M. (Maurizio), Beretta, L. (Luigi), Blaabjerg, M. (Morten), Bragge, P. (Peter), Brazinova, A. (Alexandra), Brinck, V. (Vibeke), Brooker, J. (Joanne), Brorsson, C. (Camilla), Buki, A. (Andras), Bullinger, M. (Monika), Cabeleira, M. (Manuel), Caccioppola, A. (Alessio), Calappi, E. (Emiliana), Calvi, M.R. (Maria Rosa), Cameron, P. (Peter), Lozano, G.C. (Guillermo Carbayo), Carbonara, M. (Marco), Cavallo, S. (Simona), Chevallard, G. (Giorgio), Chieregato, A. (Arturo), Ceyisakar, I.E. (Iris), Coburn, M. (Mark), Coles, J.P. (Jonathan P.), Cooper, J.D. (Jamie D.), Correia, M. (Marta), Covic, A. (Amra), Curry, N. (Nicola), Czeiter, E. (Endre), Czosnyka, M. (Marek), Dahyot-Fizelier, C. (Claire), Dark, P. (Paul), Dawes, H. (Helen), De Keyser, V. (Véronique), Degos, V. (Vincent), Corte, F.D. (Francesco Della), den Boogert, H. (Hugo), Depreitere, B. (Bart), Đilvesi, Đ. (Đula), Dixit, A. (Abhishek), Donoghue, E. (Emma), Dreier, J.P. (Jens), Dulière, G.-L. (Guy-Loup), Ercole, A. (Ari), Esser, P. (Patrick), Ezer, E. (Erzsébet), Fabricius, M. (Martin), Feigin, V.L. (Valery L.), Foks, K.A. (Kelly), Frisvold, S.K. (Shirin Kordasti), Furmanov, A. (Alex), Gagliardo, P. (Pablo), Galanaud, D. (Damien), Gantner, D. (Dashiell), Gao, G. (Guoyi), George, P. (Pradeep), Ghuysen, A. (Alexandre), Giga, L. (Lelde), Glocker, B. (Ben), Golubovic, J. (Jagoš), Gomez, P.A. (Pedro A.), Gratz, J. (Johannes), Gravesteijn, B.Y. (Benjamin), Grossi, F. (Francesca), Gruen, R.L. (Russell), Gupta, D. (Deepak), Haagsma, J.A. (Juanita), Haitsma, I. (Iain), Helbok, R. (Raimund), Helseth, E. (Eirik), Horton, L. (Lindsay), Huijben, A.L.C.J.R.M. (Jilske), Hutchinson, P.J. (Peter J.), Jacobs, B.C. (Bart), Jankowski, S. (Stefan), Jarrett, M. (Mike), Jiang, J.-Y. (Ji-Yao), Johnson, F. (Faye), Jones, K.M. (Kelly M.), Karan, M. (Mladen), Kolias, A.G. (Angelos G.), Kondziella, D. (Daniel), Koraropoulos, E. (Evgenios), Koskinen, L.-O. (Lars-Owe), Kovács, N. (Noémi), Kowark, A. (Ana), Lagares, A. (Alfonso), Lanyon, L. (Linda), Laureys, S. (Steven), Lecky, F.E. (Fiona), Ledoux, D. (Didier), Lefering, R., Legrand, V. (Valerie), Lejeune, A. (Aurelie), Levi, L. (Leon), Lightfoot, R. (Roger), Castaño-León, A.M. (Ana M.), Maegele, M. (Marc), Majdan, M. (Marek), Manara, A. (Alex), Manley, G. (Geoffrey), Martino, C. (Costanza), Maréchal, H. (Hugues), Mattern, J. (Julia), McMahon, C. (Catherine), Melegh, B. (Béla), Menon, D.K. (David ), Menovsky, T. (Tomas), Misset, B. (Benoit), Mulazzi, D. (Davide), Muraleedharan, V. (Visakh), Murray, L. (Lynnette), Negru, A. (Ancuta), Nelson, D. (David), Newcombe, V.F. (Virginia F.), Nieboer, D. (Daan), Nyirádi, J. (József), Olubukola, O. (Otesile), Oresic, M. (Matej), Ortolano, F. (Fabrizio), Palotie, A. (Aarno), Parizel, P.M., Payen, J.-F. (Jean-François), Perera, N. (Natascha), Perlbarg, V. (Vincent), Persona, P. (Paolo), Peul, W.C. (Wilco), Piippo-Karjalainen, A. (Anna), Pirinen, M. (Matti), Ples, H. (Horia), Polinder, S. (Suzanne), Pomposo, I. (Inigo), Posti, J.P. (Jussi P.), Puybasset, L. (Louis), Radoi, A. (Andreea), Ragauskas, A. (Arminas), Raj, R. (Rahul), Rambadagalla, M. (Malinka), Rhodes, J.K.J. (Jonathan K.J.), Richardson, S. (Sylvia), Richter, S. (Sophie), Ripatti, S. (Samuli), Rocka, S. (Saulius), Roe, C. (Cecilie), Roise, O. (Olav), Rosand, J. (Jonathan), Rosenfeld, J.V. (Jeffrey V.), Rosenlund, C. (Christina), Rosenthal, G. (Guy), Rossaint, R. (Rolf), Rossi, S. (Sandra), Rueckert, D. (Daniel), Rusnák, M. (Martin), Sahuquillo, J. (Juan), Sakowitz, O. (Oliver), Sanchez-Porras, R. (Renan), Sandor, J. (Janos), Schäfer, N. (Nadine), Schmidt, S. (Silke), Schoechl, H. (Herbert), Schoonman, G.G. (Guus), Schou, R. (Rico), Schwendenwein, E. (Elisabeth), Sewalt, C.A. (Charlie), Skandsen, T. (Toril), Smielewski, P. (Peter), Sorinola, A. (Abayomi), Stamatakis, E. (Emmanuel), Stanworth, S. (Simon), Stevens, R. (Robert), Stewart, W. (William), Steyerberg, E.W. (Ewout), Sundström, N. (Nina), Synnot, A. (Anneliese), Takala, R. (Riikka), Tamás, V. (Viktória), Tamosuitis, T. (Tomas), Taylor, M.S. (Mark Steven), Ao, B.T. (Braden Te), Tenovuo, O. (Olli), Theadom, A. (Alice), Thomas, M. (Matt), Tibboel, D. (Dick), Tolias, C.M. (Christos M.), Trapani, T. (Tony), Tudora, C.M. (Cristina Maria), Vajkoczy, P. (Peter), Vallance, S. (Shirley), Valeinis, E. (Egils), Vámos, Z. (Zoltán), Van der Steen, G. (Gregory), Naalt, J. (Joukje) van der, van Essen, T.A. (Thomas A.), Hecke, W. (Wim) van, van Heugten, C.M. (Caroline M.), Van Praag, D. (Dominique), Vyvere, T.V. (Thijs Vande), Vargiolu, A. (Alessia), Vega, E. (Emmanuel), Velt, K.B. (Kimberley), Verheyden, J. (Jan), Vespa, P.M. (Paul M.), Vik, A. (Anne), Vilcinis, R. (Rimantas), Volovici, V. (Victor), Von Steinbüchel, N. (Nicole), Voormolen, D.C. (Daphne), Vulekovic, P. (Peter), Wang, K.K.W. (Kevin), Wiegers-Groeneweg, E.J.A. (Eveline), Williams, G. (Guy), Wilson, L. (Lindsay), Winzeck, S. (Stefan), Wolf, S. (Stefan), Yang, Z. (Zhihui), Ylén, P. (Peter), Younsi, A. (Alexander), Zeiler, F.A. (Frederick A.), Zelinkova, V. (Veronika), Ziverte, A. (Agate), and Zoerle, T. (Tommaso)
Abstract: Purpose: Enrolling traumatic brain injury (TBI) patients with an inability to provide informed consent in research is challenging. Alternatives to patient consent are not sufficiently embedded in European and national legislation, which allows procedural variation and bias. We aimed to quantify variations in informed consent policy and practice. Methods: Variation was explored in the CENTER-TBI study. Policies were reported by using a questionnaire and national legislation. Data on used informed consent procedures were available for 4498 patients from 57 centres across 17 European countries. Results: Variation in the use of informed consent procedures was found between and within EU member states. Proxy informed consent (N = 1377;64%) was the most frequently used type of consent in the ICU, followed by patient informed consent (N = 426;20%) and deferred consent (N = 334;16%). Deferred consent was only actively used in 15 centres (26%), although it was considered valid in 47 centres (82%). Conclusions: Alternatives to patient consent are essential for TBI research. While there seems to be concordance amongst national legislations, there is regional variability in institutional practices with respect to the use of different informed consent procedures. Variation could be caused by several reasons, including inconsistencies in clear legislation or knowledge of such legislation amongst researchers.
Published: 2020
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50. The International Virus Bioinformatics Meeting 2020

Author: Hufsky, F. (Franziska), Beerenwinkel, N. (Niko), Meyer, I.M. (Irmtraud M.), Roux, S. (Simon), Cook, G.M. (Georgia May), Kinsella, C.M. (Cormac M.), Lamkiewicz, K. (Kevin), Marquet, M. (Mike), Nieuwenhuijse, D.F. (David F.), Olendraite, I. (Ingrida), Paraskevopoulou, S. (Sofia), Young, F. (Francesca), Dijkman, R. (Ronald), Ibrahim, B. (Bashar), Kelly, J. (Jenna), Le Mercier, P. (Philippe), Marz, M. (Manja), Ramette, A. (Alban), Thiel, V. (Volker), Hufsky, F. (Franziska), Beerenwinkel, N. (Niko), Meyer, I.M. (Irmtraud M.), Roux, S. (Simon), Cook, G.M. (Georgia May), Kinsella, C.M. (Cormac M.), Lamkiewicz, K. (Kevin), Marquet, M. (Mike), Nieuwenhuijse, D.F. (David F.), Olendraite, I. (Ingrida), Paraskevopoulou, S. (Sofia), Young, F. (Francesca), Dijkman, R. (Ronald), Ibrahim, B. (Bashar), Kelly, J. (Jenna), Le Mercier, P. (Philippe), Marz, M. (Manja), Ramette, A. (Alban), and Thiel, V. (Volker)
Abstract: The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally decided at short notice to go fully online. On the other hand, the pandemic has made us even more aware of the importance of accelerating research in viral bioinformatics. Advances in bioinformatics have led to improved approaches to investigate viral infections and outbreaks. The International Virus Bioinformatics Meeting 2020 has attracted approximately 120 experts in virology and bioinformatics from all over the world to join the two-day virtual meeting. Despite concerns being raised that virtual meetings lack possibilities for face-to-face discussion, the participants from this small community created a highly interactive scientific environment, engaging in lively and inspiring discussions and suggesting new research directions and questions. The meeting featured five invited and twelve contributed talks, on the four main topics: (1) proteome and RNAome of R
Published: 2020
Full Text: View/download PDF

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