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16 results on '"Ezzell, Jennifer A."'

1. Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

Author

Zhang, Wencheng, Wang, Xicheng, Lanzoni, Giacomo, Wauthier, Eliane, Simpson, Sean, Ezzell, Jennifer Ashley, Allen, Amanda, Suitt, Carolyn, Krolik, Jonah, Jhirad, Alexander, Dominguez-Bendala, Juan, Cardinale, Vincenzo, Alvaro, Domenico, Overi, Diletta, Gaudio, Eugenio, Sethupathy, Praveen, Carpino, Guido, Adin, Christopher, Piedrahita, Jorge A, Mathews, Kyle, He, Zhiying, and Reid, Lola McAdams

Published
2023
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2. A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

Author

Zhang, Wencheng, Wang, Xicheng, Lanzoni, Giacomo, Wauthier, Eliane, Simpson, Sean, Ezzell, Jennifer Ashley, Allen, Amanda, Suitt, Carolyn, Krolik, Jonah, Jhirad, Alexander, Dominguez-Bendala, Juan, Cardinale, Vincenzo, Alvaro, Domenico, Overi, Diletta, Gaudio, Eugenio, Sethupathy, Praveen, Carpino, Guido, Adin, Christopher, Piedrahita, Jorge A, Mathews, Kyle, He, Zhiying, and Reid, Lola McAdams

Published
2023
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3. Patch grafting of organoids of stem/progenitors into solid organs can correct genetic-based disease states

Author

Zhang, Wencheng, Wauthier, Eliane, Lanzoni, Giacomo, Hani, Homayoun, Yi, Xianwen, Overi, Diletta, Shi, Lei, Simpson, Sean, Allen, Amanda, Suitt, Carolyn, Ezzell, Jennifer Ashley, Alvaro, Domenico, Cardinale, Vincenzo, Gaudio, Eugenio, Carpino, Guido, Prestwich, Glenn, Dominguez-Bendala, Juan, Gerber, David, Mathews, Kyle, Piedrahita, Jorge, Adin, Christopher, Sethupathy, Praveen, He, Zhiying, and Reid, Lola M.

Published
2022
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4. The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma

Author

Karachaliou, Georgia Sofia, Alkallas, Rached, Carroll, Sarah B., Caressi, Chongshan, Zakria, Danny, Patel, Nirali M., Trembath, Dimitri G., Ezzell, Jennifer A., Pegna, Guillaume J., Googe, Paul B., Galeotti, Jonathan P., Ayvali, Fatih, Collichio, Frances A., Lee, Carrie B., Ollila, David W., Gulley, Margaret L., Johnson, Douglas B., Kim, Kevin B., Watson, Ian R., and Moschos, Stergios J.

Published
2022
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5. TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis

Author

Evangelista, Baggio Angelo, primary, Ragusa, Joey Vincent, additional, Pellegrino, Kyle, additional, Wu, Yija, additional, Quiroga-Barber, Ivana, additional, Cahalan, Shannon R, additional, Arooji, Omeed K, additional, Madren, Jillann A, additional, Schroeter, Sally, additional, Cozzarin, Joe, additional, Xie, Ling, additional, Chen, Xian, additional, White, Kristen K, additional, Ezzell, Jennifer Ashley, additional, Iannone, Marie Anne, additional, Cohen, Sarah, additional, Traub, Rebecca E, additional, Li, Xiaoyan, additional, Bedlack, Richard, additional, Phanstiel, Douglas H, additional, Meeker, Rick, additional, Stanley, Natalie, additional, and Cohen, Todd J, additional

Published
2024
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6. RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

Author

Necarsulmer, Julie, primary, Simon, Jeremy, additional, Evangelista, Baggio, additional, Chen, Youjun, additional, Tian, Xu, additional, Nafees, Sara, additional, Gonzalez, Ariana Marquez, additional, Jiang, Huijun, additional, Wang, Ping, additional, Ajit, Deepa, additional, Nikolova, Viktoriya, additional, Harper, Kathryn, additional, Ezzell, Jennifer, additional, Lin, Feng-Chang, additional, Beltran, Adriana, additional, Moy, Sheryl, additional, and Cohen, Todd, additional

Published
2023
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7. Increased Tryptophan, But Not Increased Glucose Metabolism, Predict Resistance of Pembrolizumab in Stage III/IV Melanoma

Author

Oldan, Jorge D., primary, Giglio, Benjamin C., additional, Smith, Eric, additional, Zhao, Weiling, additional, Bouchard, Deeanna M., additional, Ivanovic, Marija, additional, Lee, Yueh Z., additional, Collichio, Frances A., additional, Meyers, Michael, additional, Wallack, Diana E., additional, Abernethy-Leinwand, Amber, additional, Long, Patricia K., additional, Trembath, Dimitri G., additional, Googe, Paul B., additional, Kowalski, Madeline H., additional, Ivanova, Anastasia, additional, Ezzell, Jennifer, additional, Feinberg, Nana, additional, Thomas, Nancy E., additional, Wong, Terence Z., additional, Ollila, David W., additional, Li, Zibo, additional, and Moschos, Stergios J., additional

Published
2022
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8. A TDP-43 acetylation-mimic mutation that disrupts RNA-binding drives FTLD-like neurodegeneration in a mouse model of sporadic TDP-43 proteinopathy

Author

Necarsulmer, Julie, primary, Simon, Jeremy, additional, Evangelista, Baggio, additional, Chen, Youjun, additional, Tian, Xu, additional, Nafees, Sara, additional, Gonzalez, Ariana Marquez, additional, Wang, Ping, additional, Ajit, Deepa, additional, Nikolova, Viktoriya, additional, Harper, Kathryn, additional, Ezzell, Jennifer, additional, Beltran, Adriana, additional, Moy, Sheryl, additional, and Cohen, Todd, additional

Published
2022
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9. Additional file 1 of The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma

Author

Karachaliou, Georgia Sofia, Alkallas, Rached, Carroll, Sarah B., Caressi, Chongshan, Zakria, Danny, Patel, Nirali M., Trembath, Dimitri G., Ezzell, Jennifer A., Pegna, Guillaume J., Googe, Paul B., Galeotti, Jonathan P., Ayvali, Fatih, Collichio, Frances A., Lee, Carrie B., Ollila, David W., Gulley, Margaret L., Johnson, Douglas B., Kim, Kevin B., Watson, Ian R., and Moschos, Stergios J.

Abstract

Additional file 1: Supplementary Data.

Published
2022
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11. Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.

Author

Oldan, Jorge D., Giglio, Benjamin C., Smith, Eric, Zhao, Weiling, Bouchard, Deeanna M., Ivanovic, Marija, Lee, Yueh Z., Collichio, Frances A., Meyers, Michael O., Wallack, Diana E., Abernethy-Leinwand, Amber, Long, Patricia K., Trembath, Dimitri G., Googe, Paul B., Kowalski, Madeline H., Ivanova, Anastasia, Ezzell, Jennifer A., Nikolaishvili-Feinberg, Nana, Thomas, Nancy E., and Wong, Terence Z.

Subjects
IPILIMUMAB, MELANOMA, GLUCOSE metabolism, ESSENTIAL amino acids, TRYPTOPHAN, POSITRON emission tomography, PEMBROLIZUMAB, PROGNOSIS
Abstract

Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essential. We immunohistochemically stained tissues along the nevus-to-MM progression pathway for tryptophan-metabolizing enzymes (TMEs; TPH1, TPH2, TDO2, IDO1) and the tryptophan transporter, LAT1. We assessed tryptophan and glucose metabolism by performing baseline C11-labeled α-methyl tryptophan (C11-AMT) and fluorodeoxyglucose (FDG) PET imaging of tumor lesions in a prospective clinical trial of pembrolizumab in MM (clinicaltrials.gov, NCT03089606). We found higher protein expression of all TMEs and LAT1 in melanoma cells than tumor-infiltrating lymphocytes (TILs) within MM tumors (n = 68). Melanoma cell-specific TPH1 and LAT1 expressions were significantly anti-correlated with TIL presence in MM. High melanoma cell-specific LAT1 and low IDO1 expression were associated with worse overall survival (OS) in MM. Exploratory optimal cutpoint survival analysis of pretreatment 'high' vs. 'low' C11-AMT SUVmax of the hottest tumor lesion per patient revealed that the 'low' C11-AMT SUVmax was associated with longer progression-free survival in our clinical trial (n = 26). We saw no such trends with pretreatment FDG PET SUVmax. Treatment of melanoma cell lines with telotristat, a TPH1 inhibitor, increased IDO expression and kynurenine production in addition to suppression of serotonin production. High melanoma tryptophan metabolism is a poor predictor of pembrolizumab response and an adverse prognostic factor. Serotoninergic but not kynurenine pathway activation may be significant. Melanoma cells outcompete adjacent TILs, eventually depriving the latter of an essential amino acid. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Patch Grafting of Stem/Progenitor Organoids, Strategies for Cell Therapies for Solid Organs, and Exemplified in Liver and Pancreas

Author

Zhang, Wencheng, primary, Lanzoni, Giacomo, additional, Hani, Homayoun, additional, Yi, Xianwen, additional, Overi, Diletta, additional, Shi, Lei, additional, Simpson, Sean, additional, Allen, Amanda, additional, Suitt, Carolyn, additional, Ezzell, Jennifer Ashley, additional, Alvaro, Domenico, additional, Cardinale, Vincenzo, additional, Gaudio, Eugenio, additional, Carpino, Guido, additional, Prestwich, Glenn, additional, Dominguez-Bendala, Juan, additional, Gerber, David, additional, Sethupathy, Praveen, additional, Mathews, Kyle, additional, Piedrahita, Jorge, additional, Adin, Christopher, additional, He, Zhiying, additional, Wauthier, Eliane, additional, and Reid, Lola, additional

Published
2021
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13. High intratumoral tryptophan metabolism is a poor predictor of response to pembrolizumab (pembro) in metastatic melanoma (MM): Results from a prospective trial using baseline C11-labeled alpha-methyl tryptophan (C11-AMT) PET imaging for response prediction.

Author

Oldan, Jorge D., primary, Ollila, David W., additional, Giglio, Ben C., additional, Smith, Eric, additional, Bouchard, Deeanna M., additional, Ivanovic, Marija, additional, Lee, Yueh Z., additional, Collichio, Frances A., additional, Meyers, Michael O., additional, Wallack, Diana E., additional, Khandani, Amir H., additional, Abernathy-Leinwand, Amber, additional, Long, Patricia K., additional, Ezzell, Jennifer Ashley, additional, Trembath, Dimitri G., additional, Li, Zibo, additional, Wong, Terence Z., additional, and Moschos, Stergios J., additional

Published
2020
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14. Patch Grafting of Cells into Solid Organs Such as Liver and Pancreas

Author

Zhang, Wencheng, primary, Lanzoni, Giacomo, additional, Hani, Homayoun, additional, Yi, Xianwen, additional, Overi, Diletta, additional, Wauthier, Eliane, additional, Simpson, Sean, additional, Tokarz, Debra, additional, Jhirad, Alexander, additional, Adin, Christopher, additional, Pitman, Wendy, additional, Allen, Amanda, additional, Shi, Lei, additional, Ezzell, Jennifer Ashley, additional, Suitt, Caroline, additional, Gerber, David, additional, Prestwich, Glenn, additional, Lozoya, Oswaldo A., additional, Dominguez-Bendala, Juan, additional, Cardinale, Vincenzo, additional, Alvaro, Domenico, additional, Gaudio, Eugenio, additional, Carpino, Guido, additional, Sethupathy, Praveen, additional, Matthews, Kyle, additional, Piedrahita, Jorge, additional, and Reid, Lola, additional

Published
2020
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15. Expression of tryptophan metabolizing enzymes (TMEs) and its transporter, LAT1, in metastatic melanoma (MM): Prognostic and therapeutic implications.

Author

Trembath, Dimitri G., primary, Googe, Paul B., additional, Frank, Jill S., additional, Kowalski, Madeline H, additional, Spearman, Marcus, additional, Lagler, Taylor Marie, additional, Ezzell, Jennifer Ashley, additional, Thomas, Nancy E., additional, Ollila, David W., additional, and Moschos, Stergios J., additional

Published
2019
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