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1. The effect of cigarette smoking in plasma fibrinogen level and platelet count in male Smokers in Nnewi, Anambra State, Nigeria

Author

null ONWURAH OW, null EZE HT, null EZEAGWUNA DA, null NWACHUKWU EP, null EZE CG, null ONWUASUANYA UF, and null UZOEWULU NG

Abstract

Cigarette Smoking has been shown to induce hypercoagulability and a hyper thrombotic state, possibly by increased platelet aggregation and adhesiveness as a result of its nicotine content. During tissue and vascular injury, Fibrinogen (factor I) is converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot. This study was aimed to determine the effect of cigarette smoking in plasma fibrinogen and platelet levels in male smoker in Nnewi, Anambra state. Apparently healthy 80 male cigarette smokers and 80 male non cigarette smokers, aged between 18 and 40 years, resident in Nnewi were recruited for this study. Four milliliters of blood were collected from each participants (test and control samples), 2ml in trisodium citrate anticoagulated tubes and 2ml in EDTA for the estimation of plasma fibrinogen levels and platelets count respectively. Fibrinogen was estimated using the method described by Clauss. Platelets were estimated using Mythic 22 Automated Hematological Analyzers. The results showed a significant difference between the mean plasma Fibrinogen level in cigarette smokers and non-cigarette smokers (365.90±66.79 vs 203.02±47.40; p= 0.001). There was no significant difference observed in the mean platelets count of cigarette smokers when compared to the mean values of non-cigarette smokers (242.80±94.70 VS 202.84±76.31; p = 0.564). The study concluded that cigarettes smoking elicits an increase in the plasma fibrinogen level.

Published
2022
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2. Impact of early versus delayed umbilical cord clamping on term neonates' haemoglobin levels: a randomized controlled trial.

Author

Enyinna KP, Eleje GU, Odugu BU, Nevo CO, Ofor IJ, Mbachu II, Eze CC, Okoh DS, Ikwuka DC, Awkadigwe FI, Okafor CC, Malachy DE, Ortuanya KE, Eze HT, Okoro CC, and Okafor CG

Subjects
Humans, Female, Infant, Newborn, Pregnancy, Adult, Time Factors, Umbilical Cord surgery, Delivery, Obstetric methods, Term Birth blood, Constriction, Hemoglobins analysis, Hemoglobins metabolism, Umbilical Cord Clamping methods
Abstract

Objective: To compare the effects of early and delayed cord clamping on the haemoglobin levels of neonates delivered at term., Methods: This randomized controlled trial enrolled pregnant women during the second stage of labour. They were randomized into either the early cord clamping (ECC) group or the delayed cord clamping (DCC) group in the ratio of 1:1. Following delivery of the baby, the umbilical cords of participants in the ECC group were clamped within 30 s of delivery of the neonate while those of participants in the DCC group were clamped after 2 min from the delivery of the neonate. The primary outcome measure was the effect of ECC and DCC on the haemoglobin levels of neonates delivered at term., Results: A total of 270 pregnant women were enrolled in the study. Their baseline sociodemographic and clinical characteristics were similar in both groups. There was no significant difference in the mean haemoglobin level between ECC and DCC groups at birth. The mean haemoglobin level of the neonates at 48 h postpartum was significantly higher in the DCC group than the ECC group., Conclusion: DCC at birth was associated with a significant increase in neonatal haemoglobin levels at 48 h postpartum when compared with ECC. Trial Registration: The trial was registered at Pan African Clinical Trial Registry with approval number PACTR202206735622089., Competing Interests: Declaration of conflicting interestThe authors declare that there are no conflicts of interest.

Published
2024
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