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15 results on '"Eyestone, Will"'

3. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

Author

Mohiuddin, Muhammad M., primary, Goerlich, Corbin E., additional, Singh, Avneesh K., additional, Zhang, Tianshu, additional, Tatarov, Ivan, additional, Lewis, Billeta, additional, Sentz, Faith, additional, Hershfeld, Alena, additional, Braileanu, Gheorghe, additional, Odonkor, Patrick, additional, Strauss, Erik, additional, Williams, Brittney, additional, Burke, Allen, additional, Hittman, Jamie, additional, Bhutta, Adnan, additional, Tabatabai, Ali, additional, Gupta, Anuj, additional, Vaught, Todd, additional, Sorrells, Lori, additional, Kuravi, Kasinath, additional, Dandro, Amy, additional, Eyestone, Will, additional, Kaczorowski, David J., additional, Ayares, David, additional, and Griffith, Bartley P., additional

Published
2022
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4. Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood

Author

Miura, Shuhei, primary, Habibabady, Zahra A., additional, Pollok, Franziska, additional, Connolly, Margaret, additional, Pratts, Shannon, additional, Dandro, Amy, additional, Sorrells, Lori, additional, Karavi, Kasinath, additional, Phelps, Carol, additional, Eyestone, Will, additional, Ayares, David, additional, Burdorf, Lars, additional, Azimzadeh, Agnes, additional, and Pierson, Richard N., additional

Published
2022
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5. hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood

Author

Cimeno, Arielle, primary, Kuravi, Kasinath, additional, Sorrells, Lori, additional, Dandro, Amy, additional, Sendil, Selin, additional, Burdorf, Lars, additional, Parsell, Dawn M., additional, Eyestone, Will, additional, Phelps, Carol, additional, Ayares, David, additional, Azimzadeh, Agnes M., additional, Pierson, Richard N., additional, Barth, Rolf N., additional, and LaMattina, John C., additional

Published
2022
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7. Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 Months

Author

Mohiuddin, Muhammad, primary, Goerlich, Corbin, additional, Singh, Avneesh, additional, Zhang, Tianshu, additional, Tatarov, Ivan, additional, Lewis, Billeta, additional, Sentz, Faith, additional, Hershfeld, Alena, additional, Braileanu, Gheorghe, additional, Odonkor, Patrick, additional, Strauss, Erik, additional, Williams, Brittney, additional, Burke, Allen, additional, Hittman, Jamie, additional, Bhutta, Adnan, additional, Tabatabai, Ali, additional, Gupta, Anuj, additional, Vaught, Todd, additional, Sorrells, Lorri, additional, Kuravi, Kasinath, additional, Dandro, Amy, additional, Eyestone, Will, additional, Kaczorowski, David, additional, Ayares, David, additional, and Griffith, Bartley, additional

Published
2021
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9. Growth hormone receptor knockout: Relevance to xenotransplantation.

Author

Iwase, Hayato, Ball, Suyapa, Adams, Kent, Eyestone, Will, Walters, Anneke, and Cooper, David K. C.

Subjects
SOMATOTROPIN receptors, XENOTRANSPLANTATION, GENE knockout, TRANSPLANTATION of organs, tissues, etc., METABOLIC regulation
Abstract

Xenotransplantation research has made considerable progress in recent years, largely through the increasing availability of pigs with multiple genetic modifications, effective immunosuppressive therapy, and anti‐inflammatory therapy to protect pig tissues from the primate immune and inflammatory responses and correct molecular incompatibilities. Further study is required regarding identification and investigation of physiological incompatibilities. Although the exact cause remains uncertain, we and others have observed relatively rapid growth of kidney xenografts after transplantation into nonhuman primates (NHPs). There has also been some evidence of growth, or at least ventricular hypertrophy, of the pig heart after orthotopic transplantation into NHPs. Rapid growth could be problematic, particularly with regard to the heart within the relatively restricted confines of the chest. It has been suggested that the problem of rapid growth of the pig organ after transplantation could be resolved by growth hormone receptor (GHR) gene knockout in the pig. The GHR, although most well‐known for regulating growth, has many other biological functions, including regulating metabolism and controlling physiological processes. Genetically modified GHRKO pigs have recently become available. We provide data on their growth compared to comparable pigs that do not include GHRKO, and we have reviewed the literature regarding the effect of GHRKO, and its relevance to xenotransplantation. [ABSTRACT FROM AUTHOR]

Published
2021
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10. TALEN-Mediated Modification of the Bovine Genome for Large-Scale Production of Human Serum Albumin

Author

Moghaddassi, Shaida, Eyestone, Will, Bishop, Colin E., Moghaddassi, Shaida, Eyestone, Will, and Bishop, Colin E.

Abstract

As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimulated homology-directed repair (HDR). Pedigreed bovine fibroblasts were co-transfected with TALENs and an 11.5-kb human serum albumin (HSA) minigene donor construct, designed to simultaneously disrupt and replace bovine serum albumin (BSA) expression with controlled rHSA expression in both the liver and the milk. Targeted integration of the HSA minigene was confirmed in transfected fibroblasts at a frequency of approximately 11% and transgenic bovine embryos were produced from targeted fibroblasts using somatic cell nuclear transfer (SCNT). The research delineated here lays the foundation for the future generation of transgenic rHSA cattle with the potential to provide a large-scale, reliable, and quality-controlled source of rHSA.

Published
2014
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14. Generation Of Transgenic Dairy Cattle Using ‘in vitro’ Embryo Production

Author

Krimpenfort, Paul, primary, Rademakers, Adriana, additional, Eyestone, Will, additional, van der Schans, Adriaan, additional, van den Broek, Sandra, additional, Kooiman, Patricia, additional, Kootwijk, Erika, additional, Platenburg, Gerard, additional, Pieper, Frank, additional, Strijker, Rein, additional, and de Boer, Herman, additional

Published
1991
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15. Generation Of Transgenic Dairy Cattle Using ‘in vitro’ Embryo Production

Author

Krimpenfort, Paul, Rademakers, Adriana, Eyestone, Will, van der Schans, Adriaan, van den Broek, Sandra, Kooiman, Patricia, Kootwijk, Erika, Platenburg, Gerard, Pieper, Frank, Strijker, Rein, and de Boer, Herman

Abstract

We have combined gene transfer, by microinjection, with ‘in vitro’ embryo production technology, enabling us to carry out non-surgical transfer, to recipient cows, of microinjected embryos that have been cultured from immature oocytes. Using this approach, we have established 21 pregnancies from which 19 calves were born. Southern blot analysis proved that in two cases the microinjected DNA had been integrated in the host genome.

Published
1991
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