173 results on '"Eyelid tumor"'
Search Results
2. Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors
- Author
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Yingfeng Zheng, Principal Investigator
- Published
- 2024
3. Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
- Published
- 2023
4. Congenital solitary osseous choristoma of the left lateral canthus: a case report
- Author
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Hatim Najmi, Shaikha Aleid, Fatimah Badghaish, and Yara Alnashwan
- Subjects
Eyelid tumor ,Lateral canthus ,Osseous choristoma ,Osteoma cutis ,Ophthalmology ,RE1-994 - Abstract
Abstract Background An ocular osseous choristoma is a growth of mature, compact bone in the ocular or periocular soft tissue, and it is the rarest form of ocular choristoma, accounting for only 1.7% of all epibulbar choristomas. Case presentation Herein we present the case of a 20-month-old girl who was referred to the oculoplasty clinic with a progressively growing mass in the left lateral canthus. It had been present since birth without ocular involvement. Upon examination the mass was firm with a smooth surface, measured 9 × 6 × 3 mm, and exhibited no episcleral attachment or ocular involvement. An excisional biopsy was performed, and the histopathological findings were consistent with osseous choristoma of the left lateral canthus. Conclusions This report highlights the importance of considering osseous choristoma in the differential diagnosis of eyelid lesions, particularly those that have been present since birth. It also emphasizes the need for further studies investigating associations between osseous choristomas and ocular canthi.
- Published
- 2024
- Full Text
- View/download PDF
5. Solitary Clear Cell Renal Cell Carcinoma Metastasis to the Eyelid: A Case Report
- Author
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Ognjen Zrinšćak, Armin Kasumović, Iva Krolo, Renata Ivekovic, Maja Malenica Ravlić, Igor Tomašković, and Zoran Vatavuk
- Subjects
eyelid tumor ,eye metastasis ,renal carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: This study is a case of solitary clear cell renal cell carcinoma (ccRCC) eyelid metastasis in a 66-year-old man as the first sign of a primary tumor. ccRCC usually spreads to the lungs, mediastinum, bones, liver, and brain, while ocular metastases are rare. Case Presentation: Solitary metastasis presented as a solid mass in the central third of the upper eyelid, which has been growing for 3 weeks. Treatment included tumor removal and blepharoplasty. Histopathological examination showed metastasis of clear cell renal carcinoma. A thorough examination revealed a primary tumor on the lower pole of the right kidney. A right nephrectomy was performed, and histopathology showed ccRCC. Postoperative examinations showed no signs of local or systemic disease. Sunitinib malate was administered to the patient. Conclusion: The eyelid metastasis in this case was still solitary and had been discovered before the existence of the primary tumor was known. Ocular metastasis of renal carcinoma is a rare initial manifestation of the disease and therefore requires a multidisciplinary approach in the treatment of these patients.
- Published
- 2024
- Full Text
- View/download PDF
6. Congenital solitary osseous choristoma of the left lateral canthus: a case report.
- Author
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Najmi, Hatim, Aleid, Shaikha, Badghaish, Fatimah, and Alnashwan, Yara
- Subjects
ECTOPIC tissue ,COMPACT bone ,OPHTHALMIC plastic surgery ,DIFFERENTIAL diagnosis ,HISTOPATHOLOGY - Abstract
Background: An ocular osseous choristoma is a growth of mature, compact bone in the ocular or periocular soft tissue, and it is the rarest form of ocular choristoma, accounting for only 1.7% of all epibulbar choristomas. Case presentation: Herein we present the case of a 20-month-old girl who was referred to the oculoplasty clinic with a progressively growing mass in the left lateral canthus. It had been present since birth without ocular involvement. Upon examination the mass was firm with a smooth surface, measured 9 × 6 × 3 mm, and exhibited no episcleral attachment or ocular involvement. An excisional biopsy was performed, and the histopathological findings were consistent with osseous choristoma of the left lateral canthus. Conclusions: This report highlights the importance of considering osseous choristoma in the differential diagnosis of eyelid lesions, particularly those that have been present since birth. It also emphasizes the need for further studies investigating associations between osseous choristomas and ocular canthi. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
- Author
-
Dowell-Esquivel, Caitlin, Lee, Raphael, DiCaprio III, Robert C., and Nouri, Keyvan
- Abstract
Sebaceous carcinoma (SC) is a very rare and aggressive form of skin cancer that arises from the sebaceous glands. SC can occur anywhere on the body, but most commonly affects the head and neck, especially the upper eyelid. SC is the third most common malignancy of the eyelid and has the potential to metastasize and be fatal; therefore, it is vital for dermatologists to remain acquainted with this malignancy and its most current treatment options. Most commonly presenting as a painless lump or thickening of skin on the eyelid, SC has an insidious progression that may not prompt the patient to seek medical attention immediately. To avoid the potential of metastasis, early diagnosis and treatment is paramount. To assess if the cancer has spread, ophthalmology, imaging, and sentinel lymph node biopsy are recommended. This article provides a comprehensive review of SC’s pathogenesis, current diagnostic methods, and treatments, including wide local excision, Mohs micrographic surgery, orbital exenteration, radiation, and other topicals. The prognosis of SC depends on several factors, including size, location, stage, and treatment method. After treatment of the neoplasm, diligent post-treatment surveillance remains the cornerstone of patient care. Continued dermatologic follow-ups are essential for early detection of reoccurrence, ensuring timely intervention and optimal long-term outcomes. In conclusion, this comprehensive review aims to equip dermatologists and other physicians with a nuanced understanding of SC, enabling them to provide effective care to support patients encountering this malignancy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Solitary Clear Cell Renal Cell Carcinoma Metastasis to the Eyelid: A Case Report.
- Author
-
Zrinšćak, Ognjen, Kasumović, Armin, Krolo, Iva, Ivekovic, Renata, Malenica Ravlić, Maja, Tomašković, Igor, and Vatavuk, Zoran
- Subjects
- *
METASTASIS , *EYELIDS , *RENAL cell carcinoma , *SUNITINIB - Abstract
Introduction: This study is a case of solitary clear cell renal cell carcinoma (ccRCC) eyelid metastasis in a 66-year-old man as the first sign of a primary tumor. ccRCC usually spreads to the lungs, mediastinum, bones, liver, and brain, while ocular metastases are rare. Case Presentation: Solitary metastasis presented as a solid mass in the central third of the upper eyelid, which has been growing for 3 weeks. Treatment included tumor removal and blepharoplasty. Histopathological examination showed metastasis of clear cell renal carcinoma. A thorough examination revealed a primary tumor on the lower pole of the right kidney. A right nephrectomy was performed, and histopathology showed ccRCC. Postoperative examinations showed no signs of local or systemic disease. Sunitinib malate was administered to the patient. Conclusion: The eyelid metastasis in this case was still solitary and had been discovered before the existence of the primary tumor was known. Ocular metastasis of renal carcinoma is a rare initial manifestation of the disease and therefore requires a multidisciplinary approach in the treatment of these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Eyelid Metastasis from Cervical Cancer: A Case Report
- Author
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Jing Wen, Chunlian Huang, Nina Guo, Wenwen Wang, and Bo Sheng
- Subjects
cervical cancer ,eyelid tumor ,tumor metastasis ,case report ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Metastatic malignant lesions of the eyelids are less than 1% of all eyelid tumors. Eyelid metastasis from the cervix, particularly the first sign of metastasis, has not been reported. A female presented to an ophthalmologist with a gradually increasing mass on the lateral edge of the lower eyelid for 2 months and was diagnosed with stage IB1 cervical cancer 3 years ago. We performed wide local excision of the eyelid mass. The mass was histologically and immunohistochemically similar to cervical cancer. Upon metastatic examination, no lesions involving other sites or lymph nodes were found. Subsequently, local radiation therapy yielded the desired results. In the present case, the possibility of metastasis from the cervix was not considered for the first time. More attention should be paid when identifying unexplained masses in patients with a history of malignant tumors.
- Published
- 2023
- Full Text
- View/download PDF
10. Post-oncological full-thickness eyelid defect reconstruction: An aesthetical overview.
- Author
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Yolcu, Demet
- Subjects
EYELIDS ,BLEPHAROPLASTY ,MUSCULOCUTANEOUS flaps ,SCARS ,OPERATIVE surgery ,EYELASHES ,WOUND healing - Abstract
Purpose of the current study was to introduce a new detailed aesthetical subunit (ASU) involvement chart to localize the defect configuration on the eyelids, and, to evaluate the aesthetical and functional outcomes of the post-oncological full-thickness eyelid defect reconstruction surgery by using a modified aesthetical rating guideline. Medical records of subjects who were diagnosed with a primary malignant full thickness eyelid tumor involving the eyelid margin and underwent full-thickness eyelid defect reconstruction surgery between April 2016 and May 2022 were retrospectively reviewed. Age, sex, pathological diagnosis, follow-up time, the ASU of the eyelid involvement, and surgical methods used to reconstruct the anterior and posterior lamella were examined from medical records. The reconstructed eyelid photos were scored according to the modified aesthetical rating guideline to analyze the aesthetical and functional outcomes of the surgeries. A total of 31 subjects were included to the study, and the overall mean aesthetical score was 3.5. Seventeen subjects with aesthetical scores greater than 3.5 were included in the more aesthetically pleasing (AP) group, and 14 subjects with aesthetical score less than 3.5 were included in less AP group. Anterior lamella repair was mainly performed using myo-cutaneous flaps in the more AP group and multiple flap combinations in the less AP group (P: 0.13). Posterior lamella reconstruction was performed using tarso-conjunctival tissue in both groups. In more AP group, tissue scarring, lash line disruption, eyelid thickness, and retraction or ectropion scores were significantly higher when compared with less AP group (P:0.03, P:0.03, P:0.02, and P:0.01, respectively). Subjects with fair eyelash color were significantly more common in more AP group (P: 0.009). The ASU involvement chart and outcomes of the current study may aid novice surgeons to determine which method will provide the best result for an individual patient for full-thickness eyelid defect repair and may offer some insight into the different surgical techniques used for repairing similar wounds. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
11. Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.
- Author
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Huasheng Yang, Sun Yat-sen University
- Published
- 2021
12. Merkel Cell Carcinoma of Eyelid (MCC)
- Author
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Khalaila, Soltan, Novoa, Rosa, Samueli, Benzion, Tsumi, Erez, Ben Simon, Guy, editor, Greenberg, Gahl, editor, and Landau Prat, Daphna, editor
- Published
- 2022
- Full Text
- View/download PDF
13. Standard and modified glabellar flap for medial canthus reconstruction following mass removal in three dogs and two cats.
- Author
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Sarfaty, Havi, Ezra‐Elia, Raaya, Kahane, Nili, Sandalon, Shai, Segev, Yifat, and Sebbag, Lionel
- Subjects
- *
EYELIDS , *CATS , *MAST cell tumors , *SURGICAL site , *SURGICAL flaps , *DOGS , *SURGICAL complications - Abstract
Purpose: To describe the surgical technique and clinical outcomes of the glabellar flap and its modification for the reconstruction of the medial canthus following resection of tumors in three dogs and two cats. Methods: Three dogs (7‐, 7‐, and 12.5‐year‐old mixed breeds) and two cats (10‐ and 14‐year‐old Domestic shorthair) presented with a 7–13 mm tumor affecting the eyelid and/or conjunctiva in the medial canthal region. Following en bloc mass excision, an inverted V‐shaped skin incision was made in the glabellar region (i.e., the area between the eyebrows in humans). The apex of the inverted V‐shaped flap was rotated in three cases, whereas a horizontal sliding movement was performed in the other two cases to better cover the surgical wound. The surgical flap was then trimmed to fit the surgical wound and sutured in place in two layers (subcutaneous and cutaneous). Results: Tumors were diagnosed as mast cell tumors (n = 3), amelanotic conjunctival melanoma (n = 1), and apocrine ductal adenoma (n = 1). No recurrence was noted in a follow‐up time of 146 ± 84 days. Satisfactory cosmetic outcome with normal eyelids closure was achieved in all cases. Mild trichiasis was present in all patients and mild epiphora was noted in 2/5 patients, but there were no associated clinical signs such as discomfort or keratitis. Conclusions: The glabellar flap was easy to perform and provided a good outcome in terms of cosmetic, eyelid function, and corneal health. Postoperative complications from trichiasis appear to be minimized by the presence of the third eyelid in this region. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. Eyelid Metastasis from Cervical Cancer: A Case Report.
- Author
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Wen, Jing, Huang, Chunlian, Guo, Nina, Wang, Wenwen, and Sheng, Bo
- Subjects
- *
CERVICAL cancer , *EYELIDS , *SURGICAL excision , *METASTASIS , *LYMPH nodes ,CERVIX uteri tumors - Abstract
Metastatic malignant lesions of the eyelids are less than 1% of all eyelid tumors. Eyelid metastasis from the cervix, particularly the first sign of metastasis, has not been reported. A female presented to an ophthalmologist with a gradually increasing mass on the lateral edge of the lower eyelid for 2 months and was diagnosed with stage IB1 cervical cancer 3 years ago. We performed wide local excision of the eyelid mass. The mass was histologically and immunohistochemically similar to cervical cancer. Upon metastatic examination, no lesions involving other sites or lymph nodes were found. Subsequently, local radiation therapy yielded the desired results. In the present case, the possibility of metastasis from the cervix was not considered for the first time. More attention should be paid when identifying unexplained masses in patients with a history of malignant tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
15. Göz Kapaklarının Primer Kötü Huylu Tümörlerinin Klinik ve Histopatolojik Özellikleri.
- Author
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MUTAF, Çağrı and ŞİMŞEK, Ali
- Subjects
- *
BIOPSY , *RETROSPECTIVE studies , *CANCER relapse , *DESCRIPTIVE statistics , *HISTOLOGY , *BASAL cell carcinoma , *SQUAMOUS cell carcinoma , *SYMPTOMS ,EYELID tumors - Abstract
Background: To determine the clinical and histopathological characteristics of malignant tumors of the eyelid in terms of our region. Materials and Methods: 120 patients' files who were diagnosed with malignant eyelid tumor and followed up between January 2018 and September 2021 were scanned retrospectively in our clinic. Demographic and clinical characteristics, clinical and histopathological diagnoses, methods and follow-up results in surgical cases were recorded from the patients' files. Excisional biopsy material was obtained in all patients who underwent surgery. Results: 120 cases were included in the study. 54 (45%) of the patients were male and 66 (55%) were female. The mean age was 62.5 (35-80) years. The mean follow-up term was 20,4 months (3-36 months) for all cases. In 80% (n=96) of malignant eyelid tumors, clinical preliminary diagnosis and histopathological examination results were found to be compatible. Preoperative clinical diagnosis and postoperative histopathological diagnosis differed in 24 cases (20%). The recurrence rate was found to be 3% in all of our patients. The recurrence rates were 2% in Basal Cell Carcinoma cases and 5% in Squamous Cell Carcinoma cases. Considering the location of the tumors, 80 patients had left eyelid involvement and 40 patients had right eyelid involvement. Conclusions: Surgical excision and histopathological examination in malignant eyelid tumors are the most accurate and reliable options as they provide both diagnosis and treatment at the same time. When a malignant eyelid tumor is suspected, patients should be referred to an oculoplastic surgeon experienced in ocular oncology. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
16. Telemedicine Follow-up for Routine, Low-Risk Oculoplastic Surgery
- Published
- 2020
17. Noninvasive identification of Benign and malignant eyelid tumors using clinical images via deep learning system
- Author
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Shiqi Hui, Li Dong, Kai Zhang, Zihan Nie, Xue Jiang, Heyan Li, Zhijia Hou, Jingwen Ding, Yue Wang, and Dongmei Li
- Subjects
Deep learning ,Eyelid tumor ,Clinical image ,Computer engineering. Computer hardware ,TK7885-7895 ,Information technology ,T58.5-58.64 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract Eyelid tumors accounts for 5–10% of skin tumors. It is important but difficult to identify malignant eyelid tumors from benign lesions in a cost-effective way. Traditional screening methods for malignancy in eyelid tumors require laborious and time-consuming histopathological process. Therefore, we aimed to develop a deep learning (DL)-based image analysis system for automatic identification of benign and malignant eyelid tumors. Using a common digital camera, we collected clinical images from patients who were histopathologically diagnosed with eyelid tumors. We trained 8 convolutional neural network (CNN) models to identify benign and malignant eyelid tumors, including ResNet-50, ResNet-101, InceptionV3, and InceptionResNetV2. Another group of patients with eyelid tumors were also collected as the prospective validation dataset. Performance of DL models and human clinicians in prospective validation dataset were evaluated and compared. A total of 309 images from 209 patients were used for training DL system, all eight models reached an average accuracy greater than 0.958 in the internal cross-validation. 36 images from 36 patients were included for the prospective validation, the models reached the best performance in accuracy, sensitivity, specificity, and area under curve (AUC) of 0.889 (95% CI 0.747–0.956), 0.933 (95% CI 0.702–0.988), 0.857 (95% CI 0.654–0.950), and 0.966 (95% CI 0.850–0.993), respectively. DL system had a similar performance as the senior ophthalmologists, and outreached the performance of junior ophthalmologists and medical students. DL system can identify benign and malignant tumors through common clinical images, with a better performance than most ophthalmologists. Combining DL system with smartphone may enable patients’ self-monitoring for eyelid tumors and assist in doctors’ clinical decision making.
- Published
- 2022
- Full Text
- View/download PDF
18. Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis
- Author
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Michael H. Froehlich, Keith R. Conti, Ivy I. Norris, Jordan J. Allensworth, Nicole A. Ufkes, Shaun A. Nguyen, Evelyn T. Bruner, Joel Cook, and Terry A. Day
- Subjects
endocrine mucin-producing sweat gland carcinoma ,cutaneous adnexal tumor ,eyelid tumor ,Dermatology ,RL1-803 - Abstract
Background Endocrine mucin-producing sweat gland carcinoma is a rare, under-reported cutaneous adnexal tumor that is often misdiagnosed and has an unknown incidence of metastasis. Objective To determine the incidence of metastasis and tumor recurrence, as well as diagnostic accuracy and current trends in treatment modality. Methods A search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Tumor pathology and clinical data concerning demographics, presentation, diagnosis, treatment and follow-up were assessed. Results A total of 36 publications with 110 cases were identified. Initial pathological diagnosis was incorrect in 45.5% of cases. One case of metastatic disease was reported. The incidence of locoregional recurrence was 10.6% over a mean follow-up period of 21.3 months. Of cases with known methods of resection, 34.6% were resected by excisional biopsy, 42.8% were resected by wide surgical excision, and 31.3% were cleared by Mohs micrographic surgery. Limitations The low reported incidence and level of evidence was suboptimal with only case reports and retrospective case studies being reported. Conclusion Reported cases of this pathology demonstrate poor diagnostic accuracy. High rates of misdiagnosis and inadequate definitive treatment suggest the need for more comprehensive work-up and management of lesions suspicious for this pathology.
- Published
- 2022
- Full Text
- View/download PDF
19. Atypical presentation of invasive myoepithelioma in a pediatric patient.
- Author
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Chang, Angela Y., Tran, Ann Q., Plum, William, Tooley, Andrea A., Purushothaman, Sonya, and Kazim, Michael
- Subjects
- *
CHILD patients , *DISEASE relapse , *IMMUNOSTAINING , *SKELETAL muscle , *EYELIDS - Abstract
A 15-year-old girl presented with a mobile lesion with yellowish hue on the posterior lamella of the right lower eyelid adjacent to the punctum. Four years prior, a lesion thought to be a chalazion was excised from the same location. There was subsequent progressive painless enlargement. The patient ultimately underwent an internal excision of the mass. Histopathology demonstrated infiltrative nests and cords of epithelioid and plasmacytoid cells with abundant eosinophilic myxoid-collagenous stroma along with focal infiltration of skeletal muscle with immunohistochemical staining consistent with an invasive myoepithelioma of mixed-cell type. Given concern for invasive disease, the patient underwent subsequent Mohs resection resulting in a 25% full thickness eyelid defect, which was repaired with direct closure of the wedge defect. There has been no recurrence of the disease for 7 months since the Mohs resection. This case illustrates the atypical presentation of an invasive myoepithelioma of the eyelid in a pediatric patient. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. Unusual Presentation of Lobular Capillary Hemangioma on the Eyelid (A Case Report).
- Author
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Kamal, Fatema and Shaikh, M. Yusuf
- Subjects
- *
HEMANGIOMAS , *EYELIDS , *CAPILLARIES , *BENIGN tumors , *AMBLYOPIA , *LOBULAR carcinoma - Abstract
A lobular capillary hemangioma is a benign vascular tumor which most commonly occurs during childhood. We present the case of a 12-year-old male with acquired lobular capillary hemangioma of the left upper eyelid treated with surgical intervention. This patient developed no other lesions at the time of presentation. This case is being reported to call attention to the common occurrence in children as well as to discuss the different diagnostic and therapeutic modalities that can be used in the management of such cases. Although some cases resolve spontaneously, other cases may require intervention for cosmetic reasons or to prevent serious complications such as amblyopia and bleeding. [ABSTRACT FROM AUTHOR]
- Published
- 2023
21. Glutathione S-transferase expression in benign and malignant eyelid tumors.
- Author
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Saygın, Efe, Karadağ, Remzi, Ozkanli, Şeyma, Bozer, Büşra, Oğuztüzün, Serpil, Azari, Amir A., Özsoy Saygın, Işılay, and Bayramlar, Hüseyin
- Subjects
- *
GLUTATHIONE transferase , *EYELIDS , *GLUTATHIONE , *BENIGN tumors - Abstract
Eyelid tumors commonly originate from the skin and its appendages. Environmental toxins and oxidants affect eyelid carcinogenesis. Glutathione S-transferases (GST) are antioxidants that participate in pathogenesis. We investigated GST levels in malignant and benign eyelid tumors in otherwise healthy individuals. We used 57 malignant eyelid biopsies, benign eyelid biopsies, and tissue removed during blepharoplasty and entropion operations culled from pathology archives. Specimens were divided into three groups: malignant lesions, benign lesions and controls consisting of eyelid tissue removed during routine blepharoplasty and entropion surgery. Specimens were immunostained for seven GST (GST-A, GST-P, GST-Z, GST-S, GST-K, GST-O, GST-T) and the intensity of staining was quantified. In the malignant group, GST-O and GST-P staining was less intense than for the control group. In the benign group, the GST-P level was less than for the control group. We found no significant difference between the intensity of staining in malignant and benign groups. Our findings suggest that GST-O and GST-P enzymes may play significant roles in eyelid carcinogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
22. Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital
- Author
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Norihiro Shimizu, Toshiyuki Oshitari, Jiro Yotsukura, Hirotaka Yokouchi, Takayuki Baba, and Shuichi Yamamoto
- Subjects
Orbital tumor ,Eyelid tumor ,Malignant lymphoma ,IgG4-related diseases ,Histopathology ,Ophthalmology ,RE1-994 - Abstract
Abstract Background The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan. Methods We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. In addition, we examined the annual changes in the major types of tumors including malignant lymphomas and IgG4-related diseases (IgG4-RDs). Results There were 270 conjunctival or eyelid tumors with 166 benign and 104 malignant. There were 102 orbital tumors with 55 benign, 47 malignant tumors, and 21 cases of IgG4-RDs. Ten cases of adenoma (2.7%), another benign tumor, was also diagnosed. The major malignant tumors were malignant lymphoma in 74 cases, sebaceous gland carcinoma (SGC) in 28 cases, basal cell carcinoma in 15 cases, and squamous cell carcinoma in 8 cases. The SGCs were the most common malignant eyelid tumor at 54%. Among the malignant lymphomas, extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type, MALT lymphomas, was the most common at 51 cases and the second most common was the diffuse large B-cell lymphoma at 11 cases. The ratio of MALT lymphomas to that of all malignant lymphomas increased significantly with years. The serum IgG4 values were measured more often in the last 5 years (70%) than in the former 5 years (33%). Conclusions We conclude that malignant lymphoma is a major malignant tumor in Japan and pathological biopsies should be done proactively to prevent missing IgG4-positive MALT lymphomas.
- Published
- 2021
- Full Text
- View/download PDF
23. Noninvasive identification of Benign and malignant eyelid tumors using clinical images via deep learning system.
- Author
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Hui, Shiqi, Dong, Li, Zhang, Kai, Nie, Zihan, Jiang, Xue, Li, Heyan, Hou, Zhijia, Ding, Jingwen, Wang, Yue, and Li, Dongmei
- Subjects
EYELIDS ,DEEP learning ,MEDICAL students ,DIAGNOSTIC imaging ,CONVOLUTIONAL neural networks ,SKIN tumors ,BENIGN tumors - Abstract
Eyelid tumors accounts for 5–10% of skin tumors. It is important but difficult to identify malignant eyelid tumors from benign lesions in a cost-effective way. Traditional screening methods for malignancy in eyelid tumors require laborious and time-consuming histopathological process. Therefore, we aimed to develop a deep learning (DL)-based image analysis system for automatic identification of benign and malignant eyelid tumors. Using a common digital camera, we collected clinical images from patients who were histopathologically diagnosed with eyelid tumors. We trained 8 convolutional neural network (CNN) models to identify benign and malignant eyelid tumors, including ResNet-50, ResNet-101, InceptionV3, and InceptionResNetV2. Another group of patients with eyelid tumors were also collected as the prospective validation dataset. Performance of DL models and human clinicians in prospective validation dataset were evaluated and compared. A total of 309 images from 209 patients were used for training DL system, all eight models reached an average accuracy greater than 0.958 in the internal cross-validation. 36 images from 36 patients were included for the prospective validation, the models reached the best performance in accuracy, sensitivity, specificity, and area under curve (AUC) of 0.889 (95% CI 0.747–0.956), 0.933 (95% CI 0.702–0.988), 0.857 (95% CI 0.654–0.950), and 0.966 (95% CI 0.850–0.993), respectively. DL system had a similar performance as the senior ophthalmologists, and outreached the performance of junior ophthalmologists and medical students. DL system can identify benign and malignant tumors through common clinical images, with a better performance than most ophthalmologists. Combining DL system with smartphone may enable patients' self-monitoring for eyelid tumors and assist in doctors' clinical decision making. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
24. Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
- Author
-
Froehlich, Michael H., Conti, Keith R., Norris, Ivy I., Allensworth, Jordan J., Ufkes, Nicole A., Nguyen, Shaun A., Bruner, Evelyn T., Cook, Joel, and Day, Terry A.
- Subjects
- *
SWEAT glands , *MOHS surgery , *CLINICAL pathology , *DISEASE relapse , *METASTASIS - Abstract
Endocrine mucin-producing sweat gland carcinoma is a rare, under-reported cutaneous adnexal tumor that is often misdiagnosed and has an unknown incidence of metastasis. To determine the incidence of metastasis and tumor recurrence, as well as diagnostic accuracy and current trends in treatment modality. A search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Tumor pathology and clinical data concerning demographics, presentation, diagnosis, treatment and follow-up were assessed. A total of 36 publications with 110 cases were identified. Initial pathological diagnosis was incorrect in 45.5% of cases. One case of metastatic disease was reported. The incidence of locoregional recurrence was 10.6% over a mean follow-up period of 21.3 months. Of cases with known methods of resection, 34.6% were resected by excisional biopsy, 42.8% were resected by wide surgical excision, and 31.3% were cleared by Mohs micrographic surgery. The low reported incidence and level of evidence was suboptimal with only case reports and retrospective case studies being reported. Reported cases of this pathology demonstrate poor diagnostic accuracy. High rates of misdiagnosis and inadequate definitive treatment suggest the need for more comprehensive work-up and management of lesions suspicious for this pathology. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
25. Eyelid malignancies in young individuals: clinical peculiarities.
- Author
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Biazim, Débora F., Osaki, Midori H., Kikkawa, Don O., Liu, Catherine Y., Leonardo, Fabio, and Osaki, Tammy H.
- Abstract
Objective: The incidence of malignant eyelid tumors is considerably increasing, even in young patients. The purpose of this study was to identify particularities in individuals under 40 years of age affected by eyelid malignancies. Methods: Clinical charts of patients under 40 years of age who underwent eyelid tumor excision from 2014 to 2020 in two reference centers, one in Brazil and one in the USA, were reviewed. Demographic and outcome measures included: age, gender, skin phototype, comorbidities, diagnosis, time until diagnosis, lesion location, recurrence and metastasis. In addition, associated characteristics, including chronic sun exposure, intentional tanning (outdoor or artificial), history of smoking, use of sunscreen, family history of skin cancer and exposure to pesticides or herbicides, were reviewed. Results: A total of 24 malignant eyelid tumors from 17 patients were identified. Twelve (70.6%) patients were female, and the most prevalent tumor was basal cell carcinoma (62.5%). Three (17.6%) patients had xeroderma pigmentosum and presented with multiple lesions. Family history of skin cancer was reported by 47% of patients. Prolonged sun exposure was reported by 41.2%; history of smoking and intentional tanning were reported by 23.5 and 17.6%, respectively, and might have played a role in carcinogenesis. Conclusions: Although uncommon in young subjects, eyelid malignancies present some peculiarities in individuals under 40 years of age. Our results suggest that women with family history of skin cancer and history of chronic exposure to ultraviolet radiation are at risk. Association with genetic syndromes is also relevant among younger age groups. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
26. Hordeolum und Chalazion: (Differenzial‑)Diagnose und Therapie.
- Author
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Loth, Christiane, Miller, Christina V., Haritoglou, Christos, and Messmer, Elisabeth M.
- Abstract
Copyright of Der Ophthalmologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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- View/download PDF
27. Advancements in the repair of large upper eyelid defects: A 10-year review.
- Author
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Jennings, Erin, Krakauer, Mark, Nunery, William R., and Aakalu, Vinay Kumar
- Subjects
- *
BLEPHAROPLASTY , *EYELIDS , *PLASTIC surgery , *CONJUNCTIVA , *SURGICAL complications , *AUTHORSHIP - Abstract
The reconstruction of large (>50%) upper eyelid margin defects can be technically challenging, with multiple approaches described in the literature. We sought to review the recent literature for new techniques or modifications to existing techniques. We conducted a Pubmed search for technique papers on the reconstruction of large upper eyelid defects published within the past ten years with a minimum of four patients. We identified ten articles, and divided them into techniques that use a bridging flap from the lower eyelid and those that do not. The number of upper eyelids repaired in each article ranged from 4 to 17. Most techniques could be considered either a modification of the Cutler-Beard technique or a novel anterior lamella flap laid over a graft for the posterior lamella. Postoperative complications included upper or lower eyelid cicatricial retraction, trichiasis, entropion, and lagophthalmos. Surgeons continue to innovate for this challenging reconstructive surgery. Overall, the trend was to use a graft, most commonly tarsoconjunctiva from the contralateral upper lid, to replace the posterior lamella, and a skin flap, from the lower eyelid or from the adjacent periorbital area, to replace the anterior lamella. Bridging techniques utilized the skin; the skin, orbicularis, and conjunctiva; or a tarsoconjunctival flap from the lower eyelid. Non-bridging techniques generally used a tarsoconjunctival or substitute graft for the posterior lamella, and a skin flap for the anterior lamella. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
28. Solitary fibrofolliculoma of the upper eyelid in a 68-year old female: a case report
- Author
-
Wenqiu Wang and Jinwei Cheng
- Subjects
Solitary fibrofolliculoma ,Eyelid tumor ,Diagnosis ,Surgery ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Fibrofolliculoma is a benign, perifollicular, connective tissue tumor, and it usually arises in the form of multiple lesions, but rarely as a solitary lesion. We report a case of solitary fibrofolliculoma on the eyelid. Case presentation A 68-year-old female presented with an asymptomatic mass on the right upper eyelid. The lesion appeared as a flesh-colored, dome-shaped, smooth nodule being the size of 5 × 5 × 4 mm, with eyelashes protruding from the surface, and located on the upper lid margin. Shave excision was performed, and the diagnosis of fibrofolliculoma was confirmed finally through histological exam. Conclusions Solitary fibrofolliculomas rarely arises on the eyelid. However, it should be suspected when a flesh-colored and doom-shaped lesion of the eyelid is encountered. The benign tumor on the lid margin can be removed by shave biopsy.
- Published
- 2020
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29. Epibulbar complex choristoma with simultaneous involvement of eyelid: a case report
- Author
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Yun Hsia, Huang-Chun Lien, I-Jong Wang, Shu-Lang Liao, and Yi-Hsuan Wei
- Subjects
Epibulbar complex choristoma ,Eyelid tumor ,Congenital tumor ,Case report ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Epibulbar complex choristoma, a rare congenital epibulbar tumor, has many diverse forms. Reviewing the literature, it can present clinically as either a circumferential or isolated epibulbar mass, limbal tumor, lateral canthal mass, aggregate of ectopic cilia in the upper eyelid, eyelid mass mimicking chalazion, or lacrimal caruncle mass. The management depends on the extent of involvement, the risk of amblyopia, and cosmetic concerns. Here, we report an atypical presentation of epibulbar complex choristoma with simultaneous eyelid involvement. Case presentation A 1-month-old full-term boy was brought to our clinic with congenital epibulbar mass of the right eye with simultaneous eyelid involvement. Dilated fundus examination was unremarkable. Survey for linear nevus sebaceous Jadassohn was negative. Due to concerns of possible amblyopia and cosmetics, lamellar keratectomy, sclerotomy, and conjunctivoplasty were performed to remove the epibulbar lesion. The eyelid defect was reconstructed with 6–0 Vicryl sutures. Histopathological examination reported complex choristoma. Upon three-year follow-up, low astigmatism and favorable cosmetics results were achieved. Conclusions Congenital complex choristoma can present clinically as an epibulbar mass with eyelid involvement. The management depends on the extent of involvement, the risk of amblyopia, and cosmetic concerns. The method of eyelid reconstruction should be tailored according to the residual eyelid defect.
- Published
- 2019
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- View/download PDF
30. Thinking beyond chalazion!!!
- Author
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Harikrishnan Marappan, P Deepika Makam, and Dhatri Himanshu Karanam
- Subjects
chalazion ,eyelid tumor ,meibomian gland carcinoma ,Ophthalmology ,RE1-994 - Abstract
A 57-year-old male complained of painless swelling in the left eye upper lid for 5 months and increasing in size for 2 months. On examination, a round well-defined, firm swelling, nontender measuring 5 mm horizontally and 7 mm vertically above the lid margin in lateral part of the upper eyelid with small yellowish pustule at the lid margin corresponding to the site of lesion. The architecture of the lid and lid margin was maintained, no telangiectasia and there were no loss of eyelashes. A provisional diagnosis of marginal chalazion was made. Then incision and curettage were done. Biopsy showed invasive meibomian gland carcinoma with malignant sebocytes, numerous mitoses, and necrosis. Later, wide excision with reconstruction by tenzels flap done after edge clearance. Sebaceous gland carcinoma though rare is an aggressive tumor, and is a great mimicker of many benign conditions leading to diagnostic difficulty. Hence thinking beyond chalazion is necessary in old age, recurrent chalazion, unilateral blepharitis, keratoconjunctivitis should arise suspicion to decease the morbidity and mortality associated with the tumor.
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- 2021
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31. Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital.
- Author
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Shimizu, Norihiro, Oshitari, Toshiyuki, Yotsukura, Jiro, Yokouchi, Hirotaka, Baba, Takayuki, and Yamamoto, Shuichi
- Subjects
EYE-socket tumors ,HOSPITALS ,B cell lymphoma ,RETROSPECTIVE studies - Abstract
Background: The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.Methods: We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. In addition, we examined the annual changes in the major types of tumors including malignant lymphomas and IgG4-related diseases (IgG4-RDs).Results: There were 270 conjunctival or eyelid tumors with 166 benign and 104 malignant. There were 102 orbital tumors with 55 benign, 47 malignant tumors, and 21 cases of IgG4-RDs. Ten cases of adenoma (2.7%), another benign tumor, was also diagnosed. The major malignant tumors were malignant lymphoma in 74 cases, sebaceous gland carcinoma (SGC) in 28 cases, basal cell carcinoma in 15 cases, and squamous cell carcinoma in 8 cases. The SGCs were the most common malignant eyelid tumor at 54%. Among the malignant lymphomas, extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type, MALT lymphomas, was the most common at 51 cases and the second most common was the diffuse large B-cell lymphoma at 11 cases. The ratio of MALT lymphomas to that of all malignant lymphomas increased significantly with years. The serum IgG4 values were measured more often in the last 5 years (70%) than in the former 5 years (33%).Conclusions: We conclude that malignant lymphoma is a major malignant tumor in Japan and pathological biopsies should be done proactively to prevent missing IgG4-positive MALT lymphomas. [ABSTRACT FROM AUTHOR]- Published
- 2021
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32. The Cutler-Beard flap for upper eyelid reconstruction: Surgical indications revisited.
- Author
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Franzolin E, Quaranta Leoni F, and Quaranta Leoni FM
- Abstract
Purpose: To present the long-term outcome of the Cutler-Beard two-stage technique in patients with large full-thickness upper eyelid defects after tumor excision., Methods: The medical records of 24 patients with large full-thickness upper eyelid defects reconstructed with the Cutler-Beard technique from January 2000 to January 2021 were retrospectively reviewed. All the defects involved ≥ 60% of the horizontal length of the upper eyelid and extended vertically for at least 15 mm from the eyelid margin. Patients with follow-up < 24 months were excluded. Long-term postoperative complications, functional outcome, and patient's satisfaction at the end of the follow-up were evaluated., Results: Patients' age ranged from 36 to 88 (mean 66.0 ± 10.7 years) and 58.3% were females. Seven patients (29.2%) had had previous eyelid surgeries. The most common diagnosis was basal cell carcinoma (62.5%), followed by sebaceous gland carcinoma (12.5%), squamous cell carcinoma (8.3%), and Merkel cell carcinoma (8.3%). The mean duration of follow-up was 53.0 ± 16.9 months. Eleven patients (45.8%) developed upper eyelid entropion: 9 were treated conservatively with a therapeutic contact lens, 2 patients required a third operating stage. Most patients achieved a satisfactory functional and aesthetical outcome at the end of the follow-up., Conclusions: Although non-bridging techniques are usually favored to reconstruct large upper eyelid defects, the Cutler-Beard bridge flap is a valuable technique in case of large horizontal defects where the vertical gap is greater than 15 mm. Further surgical steps are rarely necessary; however, alternative techniques should be considered following excision of highly malignant tumors., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
33. Hornhautveränderungen bei Liderkrankungen.
- Author
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Messmer, Elisabeth M.
- Abstract
Copyright of Der Ophthalmologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
34. Solitary fibrofolliculoma of the upper eyelid in a 68-year old female: a case report.
- Author
-
Wang, Wenqiu and Cheng, Jinwei
- Subjects
EYELIDS ,SURGICAL excision ,BENIGN tumors ,CONNECTIVE tissues ,EYELASHES - Abstract
Background: Fibrofolliculoma is a benign, perifollicular, connective tissue tumor, and it usually arises in the form of multiple lesions, but rarely as a solitary lesion. We report a case of solitary fibrofolliculoma on the eyelid.Case Presentation: A 68-year-old female presented with an asymptomatic mass on the right upper eyelid. The lesion appeared as a flesh-colored, dome-shaped, smooth nodule being the size of 5 × 5 × 4 mm, with eyelashes protruding from the surface, and located on the upper lid margin. Shave excision was performed, and the diagnosis of fibrofolliculoma was confirmed finally through histological exam.Conclusions: Solitary fibrofolliculomas rarely arises on the eyelid. However, it should be suspected when a flesh-colored and doom-shaped lesion of the eyelid is encountered. The benign tumor on the lid margin can be removed by shave biopsy. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
35. Epibulbar complex choristoma with simultaneous involvement of eyelid: a case report.
- Author
-
Hsia, Yun, Lien, Huang-Chun, Wang, I-Jong, Liao, Shu-Lang, and Wei, Yi-Hsuan
- Subjects
ECTOPIC tissue ,EYELIDS ,AMBLYOPIA ,NEVUS ,LITERATURE reviews ,SEBACEOUS gland diseases ,EYE diseases ,STYE ,LACRIMAL apparatus - Abstract
Background: Epibulbar complex choristoma, a rare congenital epibulbar tumor, has many diverse forms. Reviewing the literature, it can present clinically as either a circumferential or isolated epibulbar mass, limbal tumor, lateral canthal mass, aggregate of ectopic cilia in the upper eyelid, eyelid mass mimicking chalazion, or lacrimal caruncle mass. The management depends on the extent of involvement, the risk of amblyopia, and cosmetic concerns. Here, we report an atypical presentation of epibulbar complex choristoma with simultaneous eyelid involvement.Case Presentation: A 1-month-old full-term boy was brought to our clinic with congenital epibulbar mass of the right eye with simultaneous eyelid involvement. Dilated fundus examination was unremarkable. Survey for linear nevus sebaceous Jadassohn was negative. Due to concerns of possible amblyopia and cosmetics, lamellar keratectomy, sclerotomy, and conjunctivoplasty were performed to remove the epibulbar lesion. The eyelid defect was reconstructed with 6-0 Vicryl sutures. Histopathological examination reported complex choristoma. Upon three-year follow-up, low astigmatism and favorable cosmetics results were achieved.Conclusions: Congenital complex choristoma can present clinically as an epibulbar mass with eyelid involvement. The management depends on the extent of involvement, the risk of amblyopia, and cosmetic concerns. The method of eyelid reconstruction should be tailored according to the residual eyelid defect. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
36. Eyelash hair transplantation with strip composite eyebrow graft: an enhancing technique in tarsoconjunctival flap eyelid reconstruction procedure.
- Author
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Nava-Castañeda, Ángel, Tovilla-Canales, José Luis, Solano-Leal, Paolo, and Garnica-Hayashi, Lilia
- Subjects
- *
HAIR transplantation , *EYELASHES , *EYELID surgery , *EYELIDS , *EYEBROWS , *EYE , *DESCRIPTIVE statistics - Abstract
Purpose: To describe and evaluate the eyelash transplantation with strip composite eyebrow graft to improve eyelid anatomy in tarsoconjunctival flap eyelid reconstruction procedure. Methods: Twenty two patients with eyelid tumors managed by local excision and reconstruction using tarsoconjunctival flap reconstruction procedure were included. Eyelash graft was performed during flap division by harvesting a graft from the eyebrow and creating a recipient pocket in the receptor eyelid. Patients had a 1-year follow up. Eyelash orientation and follicle survival rate were recorded. Demographic variables were analyzed with descriptive statistics. For eyelash follicles survival rate assessment, we evaluated the number of follicles found in the first postoperative day with the follicles found at the end of the study using the Wilcoxon signed rank test. P < 0.05 was considered statistically significant. Results: All eyelash grafts showed a good follicle orientation and no cases of eyelashes misdirection toward the eyeball were reported. No statistical differences (p > 0.05) were found in Wilcoxon signed rank test when comparing the number of follicles present at the first postoperative day and the number of follicles present at the 12th postoperative month, meaning that the vast majority of follicles survived at the end of the study. Graft ischemia, necrosis or infection were not observed. Conclusions: Tarsoconjunctival flap is an outstanding option for eyelid reconstruction and eyelash transplantation with an eyebrow composite graft is an excellent procedure to enhance and recreate a normal eyelid. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
37. Fibrosarcoma of the eyelid in two sibling Czech wolfdogs
- Author
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Laura Nordio, Sabina Fattori, and Chiara Giudice
- Subjects
Dog ,Eyelid tumor ,Sarcoma ,Siblings ,Zoology ,QL1-991 - Abstract
Most canine tumors of the eyelid are tumors generally encountered in the skin. They are most commonly of epithelial origin and benign. In this report, we describe the cases of two sibling Czech wolfdogs presented, one year apart, with a subcutaneous mass involving the left eyelid. Both lesions were histologically consistent with a diagnosis of subcutaneous fibrosarcoma. Immunohistochemical analyses of the tumors revealed a mild positivity for vimentin and negativity for GFAP, desmin, αSMA, myoglobin, S100, PNL2 and calponin, excluding all differential diagnosis (i.e. peripheral nerve sheath tumor, melanoma, perivascular sarcoma, myofibroblastic sarcoma, rhabdomyosarcoma). To the best of authors’ knowledge, this is the first report of canine eyelid fibrosarcoma. Since this rare tumor has been observed in two full siblings, we could speculate the existence of some genetic predisposition to sarcoma, however the present data did not allow any definite conclusion on the etiopathogenesis or genetic basis of these tumors.
- Published
- 2017
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- View/download PDF
38. Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
- Author
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Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, and Nouri K
- Subjects
- Humans, Prognosis, Sentinel Lymph Node Biopsy adverse effects, Mohs Surgery adverse effects, Adenocarcinoma, Sebaceous diagnosis, Adenocarcinoma, Sebaceous therapy, Adenocarcinoma, Sebaceous pathology, Sebaceous Gland Neoplasms diagnosis, Sebaceous Gland Neoplasms therapy, Sebaceous Gland Neoplasms pathology
- Abstract
Sebaceous carcinoma (SC) is a very rare and aggressive form of skin cancer that arises from the sebaceous glands. SC can occur anywhere on the body, but most commonly affects the head and neck, especially the upper eyelid. SC is the third most common malignancy of the eyelid and has the potential to metastasize and be fatal; therefore, it is vital for dermatologists to remain acquainted with this malignancy and its most current treatment options. Most commonly presenting as a painless lump or thickening of skin on the eyelid, SC has an insidious progression that may not prompt the patient to seek medical attention immediately. To avoid the potential of metastasis, early diagnosis and treatment is paramount. To assess if the cancer has spread, ophthalmology, imaging, and sentinel lymph node biopsy are recommended. This article provides a comprehensive review of SC's pathogenesis, current diagnostic methods, and treatments, including wide local excision, Mohs micrographic surgery, orbital exenteration, radiation, and other topicals. The prognosis of SC depends on several factors, including size, location, stage, and treatment method. After treatment of the neoplasm, diligent post-treatment surveillance remains the cornerstone of patient care. Continued dermatologic follow-ups are essential for early detection of reoccurrence, ensuring timely intervention and optimal long-term outcomes. In conclusion, this comprehensive review aims to equip dermatologists and other physicians with a nuanced understanding of SC, enabling them to provide effective care to support patients encountering this malignancy., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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- View/download PDF
39. Postoperative clinical analyze of 450 eyelid tumors.
- Author
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Balchev G and Murgova S
- Subjects
- Humans, Retrospective Studies, Eyelids surgery, Eyelids pathology, Eyelid Neoplasms surgery, Eyelid Neoplasms epidemiology, Eyelid Neoplasms pathology, Carcinoma, Basal Cell epidemiology, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell surgery, Skin Neoplasms surgery
- Abstract
Background: The eyelids are a small anatomical structure, yet they contain several histological layers from which benign and malignant tumors can originate. Compared to other parts of the face, the eyelids are often the first place where neoplasms or disease changes are noticed., Aim: To analyze localization and its predictive malignancy of eyelid tumors over a 10-year period., Method: A retrospective study of 436 (450 eyes) patients operated on over a 10-year period. Descriptive, dispersion and correlation analyzes were performed., Results: The results provide a clear assessment of the distribution and incidence of eyelid tumors according to the localization of the defect, involvement of the lash line, inflammatory response, etc. Tumor distribution is significantly skewed in favor of the medial canthus, 80% to 20% by all tumors. The involvement of the lid margin occurs in 83% of malignant tumors and has significant predictive value., Conclusion: The lower eyelid and the medial canthus are preferred locations for malignant tumors, and the upper eyelid for benign ones. Our study does not affect the types of surgical techniques; its purpose is to show the expected malignancy of the different combinations by location. The location of the tumor is a leading factor in the choice of the oculoplastic reconstructive procedure., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
40. Ocular sebaceous gland carcinoma: an update of the literature.
- Author
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Cicinelli, Maria Vittoria and Kaliki, Swathi
- Abstract
Purpose: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment. Methods: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. Results: Globally, the overall incidence of SGC is increasing making it the third most common eyelid malignancy after basal cell carcinoma (BCC) and squamous cell carcinoma. The mainstay of treatment of ocular SGC is wide surgical resection under frozen section or Moh's micrographic surgery control followed by eyelid reconstruction. Based on histopathological features, SGC can be classified according to growth pattern, cell type, and cytoarchitecture. Based on the growth pattern, they can be classified as trabecular, lobular, papillary, and BCC-like. The cell type can be classified as basaloid, basosquamous, and epidermoid. The SGC cytoarchitecture presents either as a nodular or as an infiltrative lesion. Based on immunohistochemistry, the overexpression of ZEB2, BAG3, androgen receptor, and C-erbB-2 oncoprotein is associated with poor prognosis. The tumor is associated with systemic metastasis in 8–14% and death in 10–30%. Conclusion: Ocular SGC is an aggressive tumor associated with poor prognosis. Early identification and appropriate treatment may help improve the prognosis. New insight into its pathogenesis and the immunohistochemical profile may lead to the development of new effective treatment strategies, along with traditional therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
41. Molluscum contagiosum palpébral: à propos d'un cas.
- Author
-
Moustaine, Moulay Omar, Allali, Bouchra, El Maaloum, Loubna, El Kettani, Asmaa, and Zaghloul, Khalid
- Abstract
Molluscums contagiosum (MC) are benign skin lesions caused by Molluscipoxvirus, primarily affecting children and young adults. They manly involve the skin and rarely the mucous membranes. Clinical diagnosis is easy, confirmed by histological examination of the lesion. However there is no consensus regarding therapy. Eyelid molluscum contagiosum is rare, posing a problem of differential diagnosis especially when it is isolated as well as a therapeutic problem given the proximity of the eyeball. We report the case of a 7-year old girl with isolated eyelid lesion. The patient underwent lesion excision. Anatomopathological examination showed molluscum contagiosum. This study aims to describe the clinical, therapeutic and evolutionary features of this rare localization of molluscum contagiosum. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
42. Solitary neurofibroma of eyelid masquerading as chalazion
- Author
-
Chen N, Hsu YH, and Lee YC
- Subjects
neurofibroma ,eyelid tumor ,chalazion ,Medicine (General) ,R5-920 - Abstract
Nancy Chen,1 Yung-Hsiang Hsu,2 Yuan-Chieh Lee1,3 1Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; 2Department of Pathology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; 3Department of Ophthalmology and Visual Science, Tzu Chi University, Hualien, Taiwan Abstract: Neurofibroma, a benign peripheral nerve sheath tumor, usually appears together with café-au-lait spots, iris nodules, and other tumors within the scope of neurofibromatosis von Recklinghausen type 1 tumors. A solitary neurofibroma of the eyelid is relatively rare. In this case report, we present a 39-year-old woman who had a lesion on the eyelid crease, previously treated as a chalazion. Due to persistent wound crusting, the lesion was excised above the tarsus. Pathological examination revealed a solitary neurofibroma. The patient did not have other clinical symptoms of neurofibromatosis, and there was no recurrence of the nodule during the 1-year follow-up. Keywords: neurofibroma, eyelid tumor, chalazion
- Published
- 2017
43. Severe upper eyelid mass in a patient with mycosis fungoides.
- Author
-
Yeşiltaş, Yağmur Seda, Hoşal, Melek Banu, Yüksel, Meltem Kurt, and Heper, Aylin Okçu
- Subjects
- *
CUTANEOUS T-cell lymphoma , *EYELIDS , *MYCOSIS fungoides , *SEZARY syndrome , *TUMOR diagnosis - Abstract
Mycosis fungoides is a cutaneous T-cell lymphoma that has been rarely reported to involve ocular structures. Ophthalmic manifestations usually appear in advanced disease. A case of a 58-year-old man presenting with progressive, full thickness, giant upper eyelid mass is presented. The patient had a long history of recurrent tumoral lesions on the trunk and limbs, previously diagnosed as mycosis fungoides. The histopathological examinations of eyelid tumor supported the diagnosis of mycosis fungoides. The mycosis fungoides was stage as IIB (T3N0M0B0) by TNMB classifications and referred to the Hematology and Radiation Oncology clinics. The importance of ophthalmic involvement is being seen in advanced or refractory cases, and there is a possible relation between mycosis fungoides and poor prognosis by being an early indicator of systemic involvement. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
44. [Lacrimal canalicular transposition for lower canaliculus repair: About four cases].
- Author
-
Tana C and Wavreille O
- Subjects
- Humans, Eyelids surgery, Lacrimal Apparatus surgery, Lacrimal Apparatus Diseases diagnosis, Lacrimal Apparatus Diseases etiology, Lacrimal Apparatus Diseases surgery, Eyelid Neoplasms surgery, Plastic Surgery Procedures
- Abstract
The main function of the eyelids is to support and protect the globe. The lower eyelid and medial canthus are often the location of malignant tumors that can be locally aggressive and require disfiguring surgeries. Chronic epiphora often appears in cases of inadequate reconstruction in this location and can require secondary procedures. We report four cases of medial canthus repair after tumor removal with loss of the inferior canaliculus. The ipsilateral superior canaliculus was removed before being transposed into the lower eyelid. This simple method allows for complete canalicular reconstruction. It obviates the need for artificial material and its potential associated complications. It has the advantage of a one-step eyelid and canalicular reconstruction and prevents epiphora after tumor resection., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
45. A Giant Mass in the Eyelid: Peripheral T-Cell Lymphoma, Not Otherwise Specified.
- Author
-
Yuksel N, Koc SI, Can F, and Dilek I
- Abstract
Purpose: To report a case with an unusual giant mass in the eyelid which was diagnosed as peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)., Methods: A 40-year-old woman was referred with a 1-year history of rapidly and constantly growing eyelid mass., Results: The patient underwent an incisional biopsy and histopathological examination revealed a PTCL-NOS. After achieving regression by the combination of cyclophosphamide, hydroxydoxorubicin, vincristine (oncovin), etoposide, and prednisolone therapy, the remaining crusts were debrided, the eyelids were separated, and the wound was left to heal by secondary intention. Cicatricial ectropion of the lower eyelid occurred during follow-up and it was corrected with a free skin graft successfully., Conclusion: PTCL-NOS is uncommon but it may reach massive dimensions in the eyelid region., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Journal of Current Ophthalmology.)
- Published
- 2023
- Full Text
- View/download PDF
46. Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia.
- Author
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Wohaib, Manar Al, Ahmadi, Reem Al, Essa, Dalal Al, Maktabbi, Azza, Khandekar, Rajiv, Sharif, Eman Al, Katan, Hind Al, Schellini, Silvana Artioli, and Shaikh, Osama Al
- Subjects
- *
BASAL cell carcinoma , *DEMOGRAPHIC surveys , *PRECANCEROUS conditions , *DISEASE prevalence , *TERTIARY care - Abstract
PURPOSE: Data on basal cell carcinoma (BCC) from the Middle East are deficient. We present the features and management outcomes for BCC over the last 36 years in Saudi Arabia. SUBJECTS AND METHODS: This retrospective chart review included BCC patients diagnosed and treated at Saudi Arabia between 1980 and 2016. Data were collected on patient demographics, clinical and histopathological characteristics of the lesions, management, and follow-up. RESULTS: One hundred and twenty-six patients with BCC were included in this study. The incidence of BCC in Saudi Arabia is 0.8 cases a year. The median age of the patients was 71 years. BCC affected 58.9% of males. The lower lid was the most common site of occurrence (52.7%). Clinically, BCC was most commonly recognized as a mixed lesion (41.1%) and 50.4% were histologically nodular. Risk factors for poor prognosis included tumor localization in the medial aspect of the lid, tumor size > 5 mm, histological subtype being ulcerative or morphea forms, affected margins, and recurrent lesions. CONCLUSION: BCC is a rare condition in Saudi Arabia. The clinical features and histopathology of BCC in Saudi Arabia are similar to the patterns observed in other regions of the world. Early detection and timely management mitigates the extensive destructive ocular/orbital damage due to BCC and results in better patient outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
47. Eyelid Tumor Excision and Reconstruction
- Author
-
Khan, Taj G., Stasior, George O., Stasior, Orkan George, and Brazzo, Brian G., editor
- Published
- 2003
- Full Text
- View/download PDF
48. Fibrosarcoma of the eyelid in two sibling Czech wolfdogs.
- Author
-
Nordio, Laura, Fattori, Sabina, and Giudice, Chiara
- Subjects
- *
EYELID diseases , *FIBROSARCOMA , *WOLFDOGS , *ANIMAL diseases , *IMMUNOSTAINING - Abstract
Most canine tumors of the eyelid are tumors generally encountered in the skin. They are most commonly of epithelial origin and benign. In this report, we describe the cases of two sibling Czech wolfdogs presented, one year apart, with a subcutaneous mass involving the left eyelid. Both lesions were histologically consistent with a diagnosis of subcutaneous fibrosarcoma. Immunohistochemical analyses of the tumors revealed a mild positivity for vimentin and negativity for GFAP, desmin, αSMA, myoglobin, S100, PNL2 and calponin, excluding all differential diagnosis (i.e. peripheral nerve sheath tumor, melanoma, perivascular sarcoma, myofibroblastic sarcoma, rhabdomyosarcoma). To the best of author's knowledge, this is the first report of canine eyelid fibrosarcoma. Since this rare tumor has been observed in two full siblings, we could speculate the existence of some genetic predisposition to sarcoma, however the present data did not allow any definite conclusion on the etiopathogenesis or genetic basis of these tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
49. Caracterización clinicoepidemiológica de pacientes con tumores palpebrales malignos Clinical and epidemiological characterization of patients with malignant eyelid tumors
- Author
-
Julio Cesar Arias Soto, Dania Santos Silva, Madeline de Jesús García Gali, Marlene Ortiz Silveira, and Sulli de la Caridad Matienzo Vergara
- Subjects
tumor palpebral ,carcinoma basocelular ,carcinoma escamocelular ,carcinoma epidermoide ,consulta de oftalmología ,eyelid tumor ,basal cell epithelioma ,squamous-cell carcinoma ,epidermoid carcinoma ,ophthalmology department ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Se efectuó un estudio observacional, descriptivo y transversal de 61 pacientes con tumores palpebrales malignos, atendidos en la consulta de Oftalmología del Instituto Nacional de Oncología y Radiobiología de Ciudad de La Habana, durante el 2011, a fin de caracterizarles según variables clinicoepidemiológicas de interés para la investigación. En la serie, los más afectados fueron el sexo masculino (68,6 %) y los pacientes de piel blanca (86,9 %); predominaron el grupo etario de 61-70 años (37,0 %), el carcinoma basocelular como el tumor palpebral maligno más frecuente (73,8 %) y la agricultura como la labor fundamental que realizaban los enfermos (67,2 %).An observational, descriptive and cross-sectional study was conducted in 61 patients with malignant eyelid tumors, treated at the Ophthalmology Department of the National Institute of Oncology and Radiobiology, Havana, during 2011, in order to characterize them according to clinical and epidemiological variates of interest to research. Male sex (68.6%) and white patients (86.9%) were the most affected in the series. Also, the age group of 61-70 years (37.0%), basal cell epithelioma as the most frequent malignant eyelid tumor (73.8%) and agriculture as the essential work performed by patients (67.2%) prevailed.
- Published
- 2012
50. Thinking beyond chalazion!!!
- Author
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P Deepika Makam, Harikrishnan Marappan, and Dhatri Himanshu Karanam
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,chalazion ,Lesion ,Biopsy ,eyelid tumor ,medicine ,Blepharitis ,Telangiectasia ,medicine.diagnostic_test ,business.industry ,RE1-994 ,medicine.disease ,Curettage ,eye diseases ,Surgery ,body regions ,Ophthalmology ,medicine.anatomical_structure ,Chalazion ,meibomian gland carcinoma ,Sebaceous gland carcinoma ,Eyelid ,sense organs ,medicine.symptom ,business - Abstract
A 57-year-old male complained of painless swelling in the left eye upper lid for 5 months and increasing in size for 2 months. On examination, a round well-defined, firm swelling, nontender measuring 5 mm horizontally and 7 mm vertically above the lid margin in lateral part of the upper eyelid with small yellowish pustule at the lid margin corresponding to the site of lesion. The architecture of the lid and lid margin was maintained, no telangiectasia and there were no loss of eyelashes. A provisional diagnosis of marginal chalazion was made. Then incision and curettage were done. Biopsy showed invasive meibomian gland carcinoma with malignant sebocytes, numerous mitoses, and necrosis. Later, wide excision with reconstruction by tenzels flap done after edge clearance. Sebaceous gland carcinoma though rare is an aggressive tumor, and is a great mimicker of many benign conditions leading to diagnostic difficulty. Hence thinking beyond chalazion is necessary in old age, recurrent chalazion, unilateral blepharitis, keratoconjunctivitis should arise suspicion to decease the morbidity and mortality associated with the tumor.
- Published
- 2021
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