1. Expression ofretProto-oncogene in Human Neuroblastomas
- Author
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Takashi Sugimura, Minako Nagao, Kimitoshi Kohno, Akira Nakagawara, Tomoko Tahira, Yukihito Ishizaka, Fumio Itoh, Michihiko Kuwano, and I Ikeda
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,endocrine system ,Cancer Research ,Transcription, Genetic ,endocrine system diseases ,Rna hybridization ,Gene Expression ,Dot blot ,Tumor cells ,RET proto-oncogene ,Biology ,Proto-Oncogene Mas ,Neuroblastoma ,Proto-Oncogenes ,Gene expression ,medicine ,Humans ,RNA, Messenger ,Child ,neoplasms ,Expression of ret proto‐oncogene ,Relative intensity ,Histological type ,Infant ,N‐myc amplification ,medicine.disease ,Molecular biology ,Actins ,Clinical stage ,Oncology ,Child, Preschool ,RNA ,Rapid Communication - Abstract
We examined the expression of ret proto-oncogene (proto-ret) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas examined expressed the proto-ret, the relative intensity of the hybridization ranging from 1 to 48. No correlation was found between the level of expression of proto-ret and the clinical stage. The level of expression was also not correlated with N-myc amplification, the patient's age or the histological type of the tumor. Based on the previous finding that proto-ret expression is very rarely detected in tumor cell lines other than those of neuroblastoma, proto-ret expression was suggested to be a characteristic of neuroblastomas, and possibly to be involved in the genesis of neuroblastomas.
- Published
- 1990