Search

DEHP can pose a threat to human health. However, there is no available study on the exposure levels and risk assessment of DEHP in adults nationwide. This study collected data on the concentrations of DEHP metabolites in the urine of Chinese adults through a literature review to evaluate the exposure levels and health risks of DEHP. Thirty-four articles including 15955 subjects from 2000 to 2018 were included in the study. The results showed a substantial decrease in the exposure levels of DEHP among Chinese adults from 2000 to 2018, dropping from 81.66 μg/gCr to 43.34 μg/gCr. Compared to other provinces, Shanghai (81.40 μg/gCr) and Tianjin (80.97 μg/gCr) had higher levels of DEHP. The DEHP levels for males and females were 50.27 μg/gCr and 57.64 μg/gCr, respectively. The exposure levels in the 18 ∼ 40-year-old group and above 40-year-old group were 50.84 μg/gCr and 58.23 μg/gCr, respectively. HQs were less than 1. CR values exceeded 10−6, indicating that exposure to DEHP could increase the risk of developing cancer. This study revealed that the exposure levels of DEHP for Chinese adults have shown a remarkable downward trend over time, and exposure to DEHP may pose potential health risks to Chinese adults. [ABSTRACT FROM AUTHOR]

Benzene is associated with diverse occupational and public health hazards. It exhibits an ability to rapidly permeate the skin and contaminate water and food sources, leading to dermal and ingestion exposures. Despite numerous studies examining the associations between benzene and various indicators of harm, the findings have yielded inconsistent results. Furthermore, relying solely on air concentration as a measure of benzene exposure is limited, as it fails to account for internal exposure dose and individual susceptibility. This study aimed to conduct a comprehensive review in order to present current knowledge on benzene biomarkers and their significance in evaluating exposure levels and associated health hazards. The search methodology adhered to the PRISMA guidelines and involved the application of specific inclusion and exclusion criteria across multiple databases including PubMed, Embase, and Web of Science. Two researchers independently extracted and evaluated the relevant data based on predetermined criteria. Following the screening process, a total of 80 articles were considered eligible out of the initially retrieved 1053 articles after undergoing screening and assessment for inclusion. As the level of exposure decreased, specific biomarkers demonstrated a gradual increase in limitations, including heightened background concentrations and vulnerability to confounding factors. The advancement of sampling and analysis techniques will yield new biomarkers. Additionally, when conducting practical work, it is crucial to employ a comprehensive utilization of diverse biomarkers while excluding individual metabolic variations and combined exposure factors. [ABSTRACT FROM AUTHOR]

BackgroundPer- and polyfluoroalkyl substances (PFAS) are a class of persistent organic pollu-tants. Industrial production and consumer use of PFAS are the primary sources of exposure in urban areas. E-waste recycling activities are also a significant source of environmental PFAS exposure. ObjectiveTo compare exposure profiles between traditional and emerging PFAS in neonatal cord blood collected from an e-waste recycling area and a general exposure area characterized by modern economic development (hereafter referred to as general exposure area). MethodsBased on a birth cohort study conducted in 2018, 85 pregnant women were recruited (36 participants from an e-waste recycling area and 49 participants from a general exposure area). Neonatal cord blood was collected at delivery. Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to detect 28 common PFAS in the blood. A structured questionnaire was used to gather sociodemographic characteristics of the pregnant women. Mann-Whitney U tests were used to compare PFAS exposure levels in neonatal cord blood between the e-waste recycling area and the general exposure area. Multiple linear regression models were used to explore the influence of residing in the e-waste recycling area on neonatal PFAS exposure, with area as the independent variable and the natural logarithm of PFAS exposure levels as the dependent variable. ResultsA total of 22 PFAS were positive in neonatal cord blood, of which 13 congeners were 100% detectable in the samples from both areas. The median ∑PFAS exposure levels in neonatal cord blood were 14.19 ng·mL−1 and 14.02 ng·mL−1 for the e-waste recycling area and the general exposure area, respectively, with linear perfluorooctanoic acid (L-PFOA) showing the highest median concentration (5.49 ng·mL−1 and 6.39 ng·mL−1, respectively). The results of Mann-Whitney U tests showed that the median exposure levels of long-chain perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid (PFTrDA), as well as emerging alternatives 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) and 8:2 chlorinated polyfluorinated ether sulfonate (8:2 Cl-PFESA), were higher in the e-waste recycling area than in the general exposure area. In contrast, the median exposure levels of short-chain perfluoropentanoic acid (PFPeA) and perfluorohexanoic acid (PFHxA), as well as perfluorooctanoic acid (PFOA) branched isomers, including perfluoro-6-methylheptanoic acid (iso-PFOA), perfluoro-5-methylheptanoic acid (5m-PFOA), and perfluoro-4-methylheptanoic acid (4m-PFOA), were lower in the e-waste recycling area than in the general exposure area (P

BackgroundPer- and polyfuoroalkyl substances (PFAS) are categorized as persistent organic pollutants and commonly detected in humans, and their toxicity has attracted widespread attention. However, few studies have reported comparison of PFAS levels and potential factors between women pregnant using assisted reproduction technology (ART) and women pregnant naturally. ObjectiveTo analyze and compare serum concentrations and sociodemographic determinants of PFAS in pregnant women conceiving through ART and conceiving naturally from Shanghai. MethodsBased on the China National Birth Cohort (CNBC) in Shanghai from 2017 to 2019, 333 pregnant women conceiving through ART and 689 pregnant women conceiving naturally were recruited during the same period as study subjects. The concentrations of 32 PFAS were measured in early-pregnancy serum of all pregnant women, and four PFAS with the highest co-exposure levels in both groups were included in the subsequent analysis. Multiple linear regression models were performed to evaluate the associations of sociodemographic factors with serum PFAS concentrations in the two groups respectively. Beta coefficients and 95% confidence intervals (CI) were exponentiated to calculate the ratio of the geometric mean (GM) of PFAS concentrations after each unit change in the independent variable.ResultsPerfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), 6∶2 chlorinated polyfluoroethersulfonic acid (6∶2 Cl-PFESA), and perfluorohexanesulfonic acid (PFHxS) were four major PFAS in serum of pregnant women conceiving through ART and conceiving naturally, and the concentrations of PFOA, PFOS, and 6∶2 Cl-PFESA were higher in pregnant women conceiving through ART than in pregnant women conceiving naturally (P 300000 CNY had lower serum concentrations of PFOA [GM ratio (95%CI): 0.82 (0.72, 0.95) and 0.89 (0.81, 0.97), respectively] and PFHxS [GM ratio (95%CI): 0.66 (0.51, 0.86) and 0.77 (0.66, 0.90), respectively] than those women whose household annual income

BackgroundPesticide exposure may impact the reproductive health of women undergoing assisted reproductive technology (ART). However, data on pesticide exposure levels in women undergoing ART in China are scarce, and current research on influencing factors is limited. ObjectiveTo evaluate the preconceptional pesticide exposure levels and identify potential determinants among women undergoing ART. MethodsThis study was designed as a cross-sectional survey and recruited 508 women undergoing ART from July 2017 to December 2018 at the fertility clinic of the International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Gas chromatography/liquid chromatography-tandem mass spectrometry was used to determine the metabolite concentrations of organophosphate pesticides (OPs), pyrethroid pesticides (PYRs), and neonicotinoid pesticides (NEOs) in urine. The sum of molar concentrations of the three pesticide classes (∑2OPs, ∑2PYRs, and ∑2NEOs) were calculated. A questionnaire was used to collect demographic characteristics, dietary habits, and behavioral information. Multiple linear regression was employed to analyze the associations of demographic characteristics, dietary habits, and behavioral variables with the concentrations of pesticide metabolites in urine among the participants. ResultsThe median creatinine-adjusted concentrations of ∑2OPs, ∑2PYRs, and ∑2NEOs in this study were 419.77, 2.95, and 20.36 nmol·g−1, respectively. The multiple linear regression results showed that the urinary concentration of ∑2OPs was 42.88% higher in the participants with daily vegetable intake than in those who consumed vegetables ≤3 d per week (P

Korea's aquaculture sector primarily cultivates aquatic life, with fish seed production as a focus. Formalin, a parasiticide, consists of 37% formaldehyde mixed with yellow No. 4 dye. Formaldehyde vaporization poses cancer risks, classified as a carcinogen. Korea regulates formaldehyde as a hazardous substance, requiring workplace environment measurements. Few aquaculture farms have conducted these checks in recent years. In this study, we investigated actual formaldehyde exposure levels among Korean aquaculture workers, highlighting a critical safety concern. A field survey was conducted to measure formaldehyde exposure at 10 aquaculture farms in areas where Korean aquaculture is concentrated. Short-term and long-term personal samples, local samples, and direct-reading measurements were conducted. Formaldehyde exposure levels were detected in short-term personal samples from six farms and in long-term personal samples from two farms, and formaldehyde was detected in all local samples. In direct-reading measurements, a high concentration of formaldehyde was sustained for short periods. Long-term (8-hour) personal samples were mostly non-detectable, except for farms A and D, which had levels of 0.0009 ppm and 0.0017 ppm, respectively. Short-term (15-minute) samples were non-detectable in four farms, with an average of 0.0158 (±0.0130) ppm in the remaining six farms. Local samples from all farms had an average of 0.0384 (±0.0957) ppm of formaldehyde. For farms A and D, where long-term sampling detected formaldehyde, real-time measurements showed a sustained high concentration in farm A for about 48 minutes before decreasing. Farm D had no detectable formaldehyde throughout the monitoring period. According to the formaldehyde exposure level assessment, short term exposure to formaldehyde during and immediately after application of formalin nearly exceeded the ACGIH TLV STEL in one farm. However, concentration of long term samples appeared at 10% of ACGIH TLV TWA. Additional study is recommended to determine whether exposure to formaldehyde poses a health risk for aquaculture workers during application of formalin. [ABSTRACT FROM AUTHOR]

ObjectiveTo study the association between the concentration of calcium, iron, zinc, copper, and magnesium and their ratios in whole blood and the risk of recurrent pneumonia in infants and young children, and to provide guidelines for the prevention and control of recurrent pneumonia in the population. MethodsA case-control study was conducted among 86 children (< 36 months of age) with recurrent pneumonia who were hospitalized between September 2018 and February 2019, and 174 age-matched healthy children who underwent physical examinations during the same period at Tongshan County People's Hospital in Hubei province. Relevant information on the participants was obtained from the hospital's electronic medical records, and venous blood samples were collected to measure the concentrations of the five metal elements and their ratios. Multivariate logistic regression analysis was used to assess risk factors for recurrent pneumonia in infants and young children; and receiver operating cure (ROC) analysis was used to determine the significance of ratios of mental elements in predicting recurrent pneumonia. ResultsThe cases had a lower calcium concentration than the controls (1.59 ± 0.22 vs. 1.66 ± 0.17 mmol/L), with a deficiency rate of 22.09%, but a higher copper concentration (17.62 ± 6.18 vs. 14.11 ± 2.97 μmol/L) and a higher magnesium/calcium ratio (0.95 ± 0.14 vs. 0.90 ± 0.12) and copper/zinc ratio (0.25 ± 0.07 vs. 0.20 ± 0.04). Multivariate logistic regression analysis showed that low blood calcium (odds ratio [OR] = 0.120, 95% confidence interval [CI] : 0.027 to 0.530), high blood copper (OR = 1.209, 95%CI: 1.127 to 1.298), high magnesium/calcium ratio (OR = 1.039, 95%CI: 1.015 to 1.063), and high copper/zinc ratio (OR = 1.216, 95%CI: 1.137 to 1.301) were associated with an increased risk of recurrent pneumonia in infants and young children. ROC curve analysis showed that the area under the curve (AUC) of magnesium/calcium ratio, copper/zinc ratio, and their combination in predicting recurrent pneumonia in infants were 0.608, 0.707, and 0.758, respectively (P < 0.05 for all). ConclusionThe children less than 36 months of age with recurrent pneumonia have reduced whole blood calcium but increased calcium deficiency rate, copper concentration, magnesium/calcium ratio, and copper/zinc ratio, and magnesium/calcium and copper/zinc ratios could predict the risk of recurrent pneumonia in the children to some extent.

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The number of units in the agricultural trailer and tractor park is increasing day by day. The benches, tools and machines used in the manufacturing processes of these units accelerate the production process in terms of quality and quantity in parallel with the developing technologies. However, this intensive production processes can create vulnerabilities in terms of employee health and work safety. In this study, it is aimed to examine and evaluate the agricultural trailer manufacturing process and some environmental conditions in a case workplace. In accordance with this purpose, benches and machines used in agricultural trailer production at Çanakkale were investigated. Noise and lighting levels during the operation of these machines and benches were determined in a sample workplace. In addition, evaluations were made in order to reduce the effects of the obtained noise and lighting on the employees. When the noise measurement results obtained for machines LAeq (the level of sound pressure) values were in the range of 61.74-93.33 dB(A), Lmax (the level of measured sound pressure) values were in the range of 79.53-94.3 dB(A), and LEX (exposure level) values were in the range of 47.38-80.02 dB(A). Considering the results of the study and the noise regulation, suggestions were made to reduce the effects of noise on workers. Suggestions were presented to protect them from these physical, physiological and psychological effects and to increase their working efficiency. When the measurement data results for the machines were analyzed, it was specified that the maximal illumination value which was found in the hydraulic press machine with 951 lux at Measurement 1 before noon and 1082 lux at Measurement 2 in the afternoon. It was specified that the minimal value illumination was the gas welding machine with 107 lux at Measurement 1 before noon and the lathe with 54.4 lux at Measurement 2 in the afternoon. Based on the information determined within the scope of the study, suggestions were also presented for lighting, luminaire selection, lighting calculation and lighting conditions. [ABSTRACT FROM AUTHOR]

Objective To understand the prevalence situation of stroke among urban and rural residents over 40 years old in Yibin City and the difference in the exposure levels of stroke risk factors between urban and rural areas, in order to provide a basis for formulating the appropriate prevention and control measures for stroke prevention. Methods According to the Stroke Prevention and Treatment Project of National Health Commission, the stroke survey questionnaire, physical examination and auxiliary examination were conducted among the permanent residents aged over 40 years old in two sampled towns/communities in Yibin City. The data were analyzed by SPSS22.0 software, including the general description analysis and univariate X² test. Results A total of 4 621 permanent residents aged 40 years old and above were investigated in this study, including 112 stroke patients, with a prevalence rate of 2. 42%. Among them, there were 576 cases in the high-risk groups and 778 cases in the medium-risk groups in the urban population, which were significantly higher than those in the township population, while 69 cases with previous stroke history in the urban population were also significantly more than those in the township population. The top 3 in the exposure level of stroke risk factors in the urban area of Yibin city were in turn hypertension, dyslipidemia and lack of exercise, which in the tawnship areas were in turn dyslipidemia, hypertension and smoking history. Conclusion The prevalence rate of stroke in Yibin City is similar to that in the province, but there are differences in the exposure levels of risk factors between urban and rural populations. The common risk factors in urban and rural areas include hypertension, diabetes, dyslipidemia, smoking, lack of exercise, family history of stroke, etc. [ABSTRACT FROM AUTHOR]

Objective To explore the association between whole blood lead concentration and advanced colorectal neoplasia (CRN) and to provide evidence for colorectal cancer (CRC) prevention and control. Methods The cases of the study were 272 advanced CRN identified from April 2014 to December 2016 in the participants of a CRC early diagnosis and treatment program including face-to-face questionnaire interview, physical examination and laboratory test conducted among the residents of Jiashan county, Zhejiang province; the 605 controls were gender- and age (± 5 years)-frequency matched healthy participants of the program. Results The geometric mean (geometric standard error) of whole blood lead concentration (μg/L) were 28.11(1.64) and 26.87 (0.93) for the cases and controls, without statistically significant difference (P > 0.05). After adjusting for gender, age, education, smoking, alcohol consumption, physical exercise, family history of CRC and body mass index (BMI), unconditional multivariate logistic regression analysis demonstrated that the participants with the highest quintile (Q5) of whole blood lead concentration were at an increased risk of advanced CRN (odds ratio [OR] = 1.87, 95% confidence interval [95%CI] : 1.15 – 3.04) compared to those with the lowest quintile (Q1) and the increased risk was much higher for the male participants (Q5 vs. Q1: OR = 2.12, 95%CI : 1.05 – 4.30). Furthermore after base 10 logarithm conversion, each unit increment in blood lead concentration was associated with a 1.86 (OR = 2.86, 95%CI : 1.28 – 6.35) and 3.98 (OR = 4.98, 95%CI : 1.62 – 15.35) times higher risk of advanced CRN for the all and the male participants, respectively. Restricted cubic spline analysis revealed a significant linear correlation between the increment of whole blood concentration and the increased risk of advanced CRN after adjusting for potential confounders mentioned above (χ2 total = 8.79, Ptotal = 0.012; χ2 non-linearity = 2.17, Pnon-linearity = 0.141). ConclusionBlood lead concentration may be associated with an increased risk of advanced colorectal neoplasia, suggesting a potential role of lead exposure in the etiology of colorectal carcinogenesis.

BackgroundParabens, a widely used class of preservatives, are suspected to be potential obesogens as emerging endocrine disrupting chemicals with reproductive and developmental toxicity. ObjectiveTo analyze five urinary parabens (PBs) and estimate the associations of exposure to PBs with adiposity measures in 10-year-old school-age children. MethodsA total of 471 school-age children aged 10 years from the Sheyang Mini Birth Cohort were enrolled in this study. A questionnaire survey was conducted to collect socio-demographic information, physical activity, and dietary intake. Weight, height, and waist circumference of children were measured, and age- and sex-adjusted body mass index (BMI-Z score) was calculated. Spot urine samples were collected during the follow-up visits. Urinary concentrations of five PBs including methyl-paraben (MeP), ethyl-paraben (EtP), propyl-paraben (PrP), butyl-paraben (BuP), and benzyl-paraben (BzP) were detected by gas chromatography-tandem mass spectrometry (GC-MS/MS). Generalized linear models (GLMs) and Bayesian kernel machine regression (BKMR) models were applied to estimate associations of individual/overall urinary PBs concentrations with BMI Z-score and waist circumference. ResultsThe positive rates of selected five urinary PBs were in the range from 78.98% to 98.94%. The urinary PBs concentrations (geometric mean) were in the range of 0.31-5.43 μg·L−1. The children's BMI Z-score and waist circumference (mean ± standard deviation) were (0.56±1.40) and (67.62±10.07) cm respectively. The GLMs results showed that the urinary BzP concentration was negatively associated with waist circumference (b=−0.08, 95%CI: −0.14, −0.02; P=0.01). In sex-stratified analysis, the urinary concentration of BzP was negatively associated with BMI-Z score (b=−0.59, 95%CI: −0.88, −0.30; P

Plastic products are widely used in various fields, and the discarded plastics in the environment can be degraded into microplastics (MPs) or even nanoplastics (NPs), which significantly increases the risk of organism exposure. MPs/NPs have been found in aquatic organisms, birds of prey, and even humans. The detection of plastic particles in biological samples is more complicated than that in environmental samples. Biological samples are mainly composed of various organic substances such as proteins and lipids, which makes the pretreatment process particularly critical. Effective detection and accurate quantification of MPs/NPs are crucial to health risk assessment. In this paper, the exposure levels and composition of MPs/NPs in different tissues and organs of the human body, aquatic organisms, and birds of prey were reviewed. The digestion of biological samples (acids, bases, enzymes, and hydrogen peroxide digestion protocols) and MPs/NPs identification methods (spectroscopy and chromatography) were compared and their advantages and disadvantages were assessed, providing a methodological basis for plastic exposure risk assessment and pollution control.

Occupational noise exposure is the most prominent problem in industrial enterprises in Jiangsu Province. Since 2019, China has established the National Surveillance System for Occupational Hazards in the workplace to grasp the current occupational hazards in critical industries, including occupational noise. According to the Work Plan for Surveillance of Occupational Hazards in the Workplace (2022) issued by the National Health Commission of the People’s Republic of China, the noise exposure level of 3,142 enterprises in our province was monitored, the median and interquartile range (IQR) were calculated, and the distribution of noise exposure level was described by industry classification, enterprise-scale and ownership type of the enterprise. The railway, shipping, aerospace, and other transportation equipment manufacturing industries exhibited the highest proportion (42.9%) of individual noise exposure levels exceeding 85 dB(A), followed by the motor vehicles manufacturing industry (36.4%). The proportion of individual noise exposure levels exceeding 85 dB(A) was higher in medium and small enterprises, with rates of 28.1 and 28.6%, respectively. The highest proportion of personal noise exposure levels exceeding 85 dB(A) was observed in Hong Kong, Macao and Taiwan investment enterprises (37.5%), followed by incorporated companies (34.6%) and limited liability companies (28.1%), the lowest was state-owned enterprises(15.5%). The areas with excessive noise are primarily concentrated in grinding, welding, machining, cutting, and other related operations, accounting for 61.2% of the total. Among these operations, grinding accounts for 29.8%. The highest environmental noise and individual noise intensity were found in sandblasting and grinding positions, with individual noise intensities of 115.5 dB(A) and 108.4 dB(A), respectively. The noise exposure risk is so high that cannot be ignored in the manufacturing industry, especially in Hong Kong, Macao, and Taiwan investment enterprises, incorporated companies and medium and small enterprises.

Parabens and alkylphenols pose serious hazards to human health, yet there are few studies on their exposure profiles and health risks in rural Chinese populations. In this study, 804 participants were selected from the Henan Rural Cohort in mid-eastern China. The plasma levels of parabens (methylparaben, ethylparaben, propylparaben, butylparaben (BuP)) and alkylphenols (4-tert-butylphenol (4-t-BP), 4-tert-octylphenol (4-t-OP)) were analyzed via liquid chromatography–tandem mass spectrometry. Linear regression models were used to investigate factors that may influence pollutant exposure levels. The correlation between contaminants was assessed using Spearman's correlation. The human contaminant intake was estimated using the estimated daily intake (EDI). The health risk was assessed using the hazard quotient (HQ). The detection frequency of four parabens and two alkylphenols exceeded 75%, with median concentrations of 0.444, 0.067, 0.078, 0.053, 8.810, and 6.401 ng/mL, respectively. Significant correlations were observed between parabens, as well as between 4-t-BP and 4-t-OP. Regarding gender, paraben concentrations were higher in women than in men, except for BuP. The EDI for pollutants except 4-t-OP was lower than their respective tolerable/acceptable daily intake. In total, 85.70% of participants had 4-t-OP HQ > 1. A widespread exposure to parabens and alkylphenols among the rural population was found. The high health risks of alkylphenol exposure indicate that alkylphenols should be used with caution. [ABSTRACT FROM AUTHOR]

The continuous growth of the technology allows the companies to purchase manufacturing equipment according to their needs and standards. While designing the production system the focus should be not only on the productivity but also on the ergonomic design of the workplace. One of the crucial factors for designing an ergonomic workplace is the noise. The noise in a manufacturing plant is generated from different sources depending on the industry, mainly from the machines and equipment. In this paper the level of personal noise exposure at 4 different departments in a manufacturing plant will be presented. The noise measurements were performed with dosimeters in three series. The results were downloaded and analyzed using a noise monitoring tool. According to the results presented in this paper the noise exposure level in a manufacturing plant varies depending on the noise sources located near the measurement point. [ABSTRACT FROM AUTHOR]

ObjectiveTo measure perfluoroalkyl and polyfluoroalkyl substances （PFASs） in cord blood of newborns in Henan province and explore influencing factors of PFASs exposure.MethodsThe present study was based on the birth cohort established in Henan Province from 2013 to 2015. The levels of 11 PFASs in cord blood samples （n＝336） were detected. Generalized linear regression was used to analyze the effects of maternal socio­demographic characteristics， life style and dietary intake on the level of PFASs in umbilical blood of newborns.ResultsThe newborns of older mothers （GM ratio 1.03-1.05）， higher average monthly family income （GM ratio 1.30-1.63）， pregnancy smoking （GM ratio 2.90， 95% CI：1.11， 7.56） and passive smoking （GM ratio 1.84， 95%CI： 1.02， 3.32） tend to show higher PFAS exposure in cord blood. Newborns whose mothers worked during pregnancy （GM ratio 0.82， 95%CI：0.67，1.00）， and with multiparous mothers （GM ratio 0.65， 95% CI： 0.51， 0.82） had lower concentrations of PFASs. Mothers who had higher intake frequency of beef or mutton， pumpkin， garlic seedlings and pickles during pregnancy tend to have increased concentrations of PFASs in cord blood （GM ratio was 1.33-1.80）， while the concentration was lower during mothers who consumed more oranges， milk， cabbage and eggplant during pregnancy （GM ratio was 0.68-0.82）.ConclusionMaternal age， family income， history of smoke and passively smoke during pregnancy， parity， frequency of beef or mutton， and plant­based foods intake may affect PFASs exposure of newborns.

Parabens and alkylphenols pose serious hazards to human health, yet there are few studies on their exposure profiles and health risks in rural Chinese populations. In this study, 804 participants were selected from the Henan Rural Cohort in mid-eastern China. The plasma levels of parabens (methylparaben, ethylparaben, propylparaben, butylparaben (BuP)) and alkylphenols (4-tert-butylphenol (4-t-BP), 4-tert-octylphenol (4-t-OP)) were analyzed via liquid chromatography–tandem mass spectrometry. Linear regression models were used to investigate factors that may influence pollutant exposure levels. The correlation between contaminants was assessed using Spearman’s correlation. The human contaminant intake was estimated using the estimated daily intake (EDI). The health risk was assessed using the hazard quotient (HQ). The detection frequency of four parabens and two alkylphenols exceeded 75%, with median concentrations of 0.444, 0.067, 0.078, 0.053, 8.810, and 6.401 ng/mL, respectively. Significant correlations were observed between parabens, as well as between 4-t-BP and 4-t-OP. Regarding gender, paraben concentrations were higher in women than in men, except for BuP. The EDI for pollutants except 4-t-OP was lower than their respective tolerable/acceptable daily intake. In total, 85.70% of participants had 4-t-OP HQ > 1. A widespread exposure to parabens and alkylphenols among the rural population was found. The high health risks of alkylphenol exposure indicate that alkylphenols should be used with caution.

Ozone (O3) pollution is one of the predominant environmental problems, and exposure to high O3 concentrations has a significant negative influence on both human health and ecosystems. Therefore, it is essential to analyze spatio-temporal characteristics of O3 distribution and to evaluate O3 exposure levels. In this study, O3 monitoring and satellite data were used to estimate O3 daily, seasonal and one-year exposure levels based on the Bayesian maximum entropy (BME) model with a spatial resolution of 1 km × 1 km in the Beijing-Tianjin-Hebei (BTH) region, China. Leave-one-out cross-validation (LOOCV) results showed that R2 for daily and one-year exposure levels were 0.81 and 0.69, respectively, and the corresponding values for RMSE were 19.58 μg/m3 and 4.40 μg/m3, respectively. The simulation results showed that the heavily polluted areas included Tianjin, Cangzhou, Hengshui, Xingtai, and Handan, while the clean areas were mainly located in Chengde, Qinhuangdao, Baoding, and Zhangjiakou. O3 pollution in summer was the most severe with an average concentration of 134.5 μg/m3. In summer, O3 concentrations in 87.7% of the grids were more than 100 μg/m3. In contrast, winter was the cleanest season in the BTH region, with an average concentration of 51.1 μg/m3. [ABSTRACT FROM AUTHOR]

This study aims to investigate methylmercury (MeHg) demethylation processes in human gut. Here, we determined the compositions and MeHg demethylation rates of gut microbiota in residents from different Hg exposure levels (Wanshan (WS) town and Yangtou (YT) town) and different Hg exposure sources (Zhuchang (ZC) town and YT town) regions. MeHg and inorganic Hg exposure levels in residents of WS town were significantly higher than those of YT and ZC town. Desulfovibrio and Methanogens, which related to Hg methylation/demethylation, showed significantly higher abundance in WS and ZC, comparing with YT. In vitro experiments demonstrated that human intestinal microbiota could degrade MeHg directly. Besides, gut microbiota in WS and ZC exhibited significantly higher demethylation rates than YT, suggesting Desulfovibrio and Methanogens may play important roles in intestinal MeHg demethylation. This study highlights Hg exposure levels and sources may affect demethylation efficiency of gut microbiota, which provides new insights for MeHg demethylation processes in human body. [ABSTRACT FROM AUTHOR]

Exposure to ambient air pollution is associated with an increased risk of menstrual disorders and infertility. This study examined the relationships between the levels and duration of air pollution exposure and the risk of polycystic ovarian syndrome (PCOS) using Korean population-based cohort data (2015–2019). Real-time data on PM10, PM2.5, O3, CO, SO2, and NO2 were provided by the Korean Ministry of Environment. The average monthly air pollutant concentration from 1 January 2014 to 31 December 2018 was analyzed. To assess individual-level exposure to air pollutants, a spatial prediction model and an area-averaging approach were used. In total, 237,582 PCOS cases were analyzed. The annual age-adjusted PCOS incidence was 6.70, 8.28, 9.73, 11.58, and 11.97% from 2015–2019, respectively. The PCOS risk increased 1.29–1.32, 1.43–1.52, and 1.32-fold following exposure to the 2-year and 3-year average levels of PM2.5, O3, and NO2, respectively, compared to their 1-year average levels. The PCOS risk increased 1.75-fold (95% confidence interval: 1.66–1.85) in the fourth-quartile for the NO2 level. Increased SO2 and CO levels in the second- and third-quartiles were also associated with an increased PCOS risk. Exposure to air pollutants thus increased the risk for PCOS in the Korean population. [ABSTRACT FROM AUTHOR]

Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic has rapidly spread across the whole world and brought strong psychological impact. This study aimed to evaluate the prevalence of post-traumatic stress disorders (PTSD) in the general people of southwestern China and associated factors 1 month after the outbreak of the COVID-19. Methods This study was started on 4–10 Feb 2020 based on online survey. The present work was carried out in the provinces of southeastern China, including Sichuan Province, Guizhou Province, Yunnan Province, and Chongqing City.1593 respondents aged 18 years and above administered to this study. Data on whether they have experienced confirmed or suspected COVID-19 of themselves/family members/acquaintances were also collected, and based on ‘yes’ answers, the number of affected individuals (via COVID-19) were categorized into four exposure levels i.e., non-affected, less, moderately, or significantly affected. The civilian version of the PTSD checklist and the self-reported information about COVID-19 were used. Results The prevalence of PTSD was approximately 25.2%(n = 401/1593). The chances of developing PTSD were 6.053(OR = 6.053, 95% CI 1.394 to 26.280) or 3.673(OR = 3.673, 95% CI 1.738 to 7.765) times higher among respondents who had been significantly and moderately affected than those who had not been affected, accordingly. Male (OR = 1.484, 95% CI 1.147 to 1.920),younger age individuals (40 ~ 49 age group/

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children. [ABSTRACT FROM AUTHOR]

Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years. [ABSTRACT FROM AUTHOR]

In recent years, the precision of exposure assessment methods has been rapidly improved and more widely adopted in epidemiological studies. However, such methodological advancement has introduced additional heterogeneity among studies. The precision of exposure assessment has become a potential confounding factors in meta-analyses, whose impacts on effect calculation remain unclear. To explore, we conducted a meta-analysis to integrate the long- and short-term exposure effects of PM 2.5 , NO 2 , and O 3 on all-cause, cardiovascular, and respiratory mortality in the Chinese population. Literature was identified through Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure before August 28, 2023. Sub-group analyses were performed to quantify the impact of exposure assessment precisions and pollution levels on the estimated risk. Studies achieving merely city-level resolution and population exposure are classified as using traditional assessment methods, while those achieving sub-kilometer simulations and individual exposure are considered finer assessment methods. Using finer assessment methods, the RR (under 10 μg/m3 increment, with 95% confidence intervals) for long-term NO 2 exposure to all-cause mortality was 1.13 (1.05–1.23), significantly higher (p-value = 0.01) than the traditional assessment result of 1.02 (1.00–1.03). Similar trends were observed for long-term PM 2.5 and short-term NO 2 exposure. A decrease in short-term PM 2.5 levels led to an increase in the RR for all-cause and cardiovascular mortality, from 1.0035 (1.0016–1.0053) and 1.0051 (1.0021–1.0081) to 1.0055 (1.0035–1.0075) and 1.0086 (1.0061–1.0111), with weak between-group significance (p-value = 0.13 and 0.09), respectively. Based on the quantitative analysis and literature information, we summarized four key factors influencing exposure assessment precision under a conceptualized framework: pollution simulation resolution, subject granularity, micro-environment classification, and pollution levels. Our meta-analysis highlighted the urgency to improve pollution simulation resolution, and we provide insights for researchers, policy-makers and the public. By integrating the most up-to-date epidemiological research, our study has the potential to provide systematic evidence and motivation for environmental management. [Display omitted] • The meta-analysis integrated local air pollutant exposure evidence for China. • Finer exposure assessment and lower level tend to derive higher exposure effect. • Exposure effects of NO 2 response significant to exposure assessment precisions. • We identified four key factors in exposure assessment. • Refined exposure assessment is urgent for precise environmental management. [ABSTRACT FROM AUTHOR]

ObjectiveTo analysed nutritious and harmful elements found in liquid milk marketed in different regions across China, analyzed the intake of elements from drinking milk, assessed exposure to elements and health risks in adults, and provided basis for relevant standards.MethodsAs many as 110 milk samples were collected in seven geographic regions across China. A total of 15 elements, Mg, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Mo, Cd and Pb, were determined with microwave digestion - inductively coupled plasma mass spectrometry to analyze regional differences. Recommended Nutrient Intake (RNI) and Adequate Intake (AI) were used to assess nutrition status while Margin of Exposure (MOE) and Provisional Tolerable Monthly Intake (PTMI) were used to assess health risks.ResultsThe result showed that milk generally has high level of Ca (430-939 mg/kg). The levels of 9 elements, namely Fe, Cr, Co, Mn, V, Ni, Pb, As and Cd, varied geographically. The measured concentrations of As, Pb and Cr in liquid milk were all lower than the limits of the Chinese standards. According to the result of exposure assessment, the RNIs of Mg, Ca, Se and Mo were higher than 10%. The MOE of Pb was much higher than 1. The PTMI of Cd was lower than 0.1 μg/kg BW/month, and the MOE of Ni was much higher than 10.ConclusionMilk contains abundant nutritious elements and is an important supplementary to human nutrition. In addition, milk generally contains low levels of harmful elements, which poses low risk to human health.

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to investigate smoking behaviors and nicotine exposure levels of cigarette smokers after switching to using heated tobacco products, 50 volunteers who regularly smoked cigarettes were recruited and randomly divided into two groups, one switched to a heated tobacco product known as IQOS and the other group to a domestic heated tobacco product M. Their general smoking characteristics were collected via questionnaires and their smoking parameters were recorded by a CReSS pocket analyzer. The contents of nicotine exposure biomarker in the volunteers'urine samples before and after switching were determined by HPLC-MS/MS. The results showed that: 1) The smoking behaviors of the smokers were basically unchanged after switching to the heated tobacco products, the puffing volume and duration did not change significantly. However, the puffing interval of the two groups significantly shortened from (14.3±8.0) s and (15.3±9.0) s to (9.8±8.3) s and (9.7± 5.4) s, respectively. 2) The contents of total nicotine metabolites and nicotine exposure biomarkers (i.e. cotinine) in the volunteers'urine samples did not change significantly after switching to the heated tobacco products. 3) There was no significant difference of the smoking behaviors between the volunteers switched to IQOS and those to M, and the levels of total nicotine metabolites and cotinine in the urine samples of the two groups were also quite similar. [ABSTRACT FROM AUTHOR]

After decades of development, the indoor environment in China has changed. A systematic review was conducted from peer‐reviewed scientific papers with field test data of indoor radon in China from 2000 to 2020 for three types of buildings. The mean concentrations of indoor radon for dwellings, school buildings, and office buildings are 54.6, 56.1, and 54.9 Bq/m3. The indoor radon concentration was related to seasons, climate regions, ventilation, decoration, and other factors such as soil and outdoor air. Colder seasons, especially in severe colder areas of China, newer decorated buildings, closed windows, and doors were all associated with higher indoor radon concentrations. Variables like climate region and ventilation showed statistical significance in the correlation analysis. Regarding the increasing trend of indoor radon concentration in China during the last two decades, further study of indoor radon is necessary especially for school buildings and office buildings, and will help access its environmental burden of disease in China more accurately. [ABSTRACT FROM AUTHOR]

Objective A case-control study on Clostridium spp. contamination on infant population and infant formula powdered was carried out, the data on Clostridium spp. exposure in some parts of China was obtained. Methods Epidemiological information and samples were collected from 6 locations in 6 provinces in China. The isolation and identification, of Clostridium spp. were performed. Results Totally 501 infants were investigated. Among them, 247 were exclusive breastfeeding and 254 were mixed feeding. According to the month grouping, 367 were 0-6 months and 134 were 7-12 months. A total of 813 samples were collected. After testing, 246 strains of Clostridium spp. were obtained and the positive rate was 30.3% (246/813). C. sporogenes (8.4%, 68/813), C. bifermentans (6.2%, 50/813) and C. butyricum (4.6%, 37/813) had the highest detection rate.37.3% (187/501) of the stool samples were Clostridium spp. positive, followed by 22.3% (27/121) of the infant formula powder, 19.5% (25/128) of the environmental swab and 11.1% (7/63) of the food samples. The detection rate of Clostridium spp. in mixed feeding group was significantly higher than that of breast-feeding group (χ2=40.833, P

Introduction: Systemic lupus erythematosus (SLE) can affect bone metabolism and homeostasis of serum electrolytes that are associated with abnormal levels of vitamin D. Mycophenolate mofetil (MMF) is a commonly used immunosuppressant with the active metabolite mycophenolic acid (MPA). The area under the plasma concentration–time curve (AUC) of MPA is often monitored during the treatment to assess the exposure levels. This study aims to explore the association between exposure levels of MPA and 25-hydroxyvitamin D [25(OH)D] levels in children with SLE. Methods: Repeated measured data of children with SLE who were treated with MMF and under therapeutic drug monitoring (TDM) were retrospectively collected from the electronic medical records. MPA exposure levels were reflected by the area under the concentration–time curve over 24 h (AUC0–24h). Univariate and multivariate linear regression models were employed to analyze factors associated with 25(OH)D levels. Hierarchical linear models were developed to analyze the intra- and inter-individual effects of AUC0–24h on the variance of 25(OH)D levels. Results: Data from 184 children with SLE (142 female and 42 male) with 518 follow-ups were collected. The median age was 14 years (range 3–18 years) at TDM. Children with normal 25(OH)D levels had significantly higher AUC0–24h than children with low 25(OH)D levels (98.71 vs. 84.05 mg·h/L, P = 0.004). Intra- and inter-individual effects of AUC0–24h on 25(OH)D levels were similar ( γ 10 = 0.034 vs. γ 01 = 0.037) but only the intra-individual effect was significant (P = 0.001) in hierarchical models. Other associated factors include age, sex, season at measurement, glucocorticoid daily dose, and external vitamin D3 supplements. Conclusion: 25(OH)D levels are associated with MPA exposure levels, and may serve as a potential indicator to optimize the exposure level of MPA during treatment. AUC0–24h of 98.71 mg·h/L or AUC0–12h of 49.36 mg·h/L could be the targeted exposure level for children with SLE. [ABSTRACT FROM AUTHOR]

The present study was conducted to determine the variations of heavy metal (Cu, Pb, Ni, Cr, Cd, and Zn) bioaccumulation in edible muscles among the wild, pond-, gher- and cage-cultured tilapia, followed by risk assessment in humans caused by consumption of the contaminated fish. A total of 120 fishes from four different aquatic environments were collected, and the heavy metal levels were analyzed using an atomic absorption spectrophotometer (AAS). The result found the highest Zn concentration in all tilapia samples; however, the Ni was below the detection limit. The average concentrations of metals were found as Zn > Pb > Cr > Cu in wild tilapia, Zn > Pb > Cr > Cu > Cd in pond-cultured tilapia, Zn > Pb > Cr > Cd in gher-cultured tilapia, and Zn > Cd > Cr > Pb > Cu in cage-cultured tilapia. The estimated daily intake (EDI) value was lower than the maximum tolerable daily intake value, and target hazard quotient (THQ) and hazard index (HI) for adults, adolescent, and children was < 1 for wild and cultured tilapia, indicating that tilapia is safe for human consumption. However, high HI of Pb and Cd might be alarming and need further investigation in the near future. [ABSTRACT FROM AUTHOR]

Ozone (O3) pollution is one of the predominant environmental problems, and exposure to high O3 concentrations has a significant negative influence on both human health and ecosystems. Therefore, it is essential to analyze spatio-temporal characteristics of O3 distribution and to evaluate O3 exposure levels. In this study, O3 monitoring and satellite data were used to estimate O3 daily, seasonal and one-year exposure levels based on the Bayesian maximum entropy (BME) model with a spatial resolution of 1 km × 1 km in the Beijing-Tianjin-Hebei (BTH) region, China. Leave-one-out cross-validation (LOOCV) results showed that R2 for daily and one-year exposure levels were 0.81 and 0.69, respectively, and the corresponding values for RMSE were 19.58 μg/m3 and 4.40 μg/m3, respectively. The simulation results showed that the heavily polluted areas included Tianjin, Cangzhou, Hengshui, Xingtai, and Handan, while the clean areas were mainly located in Chengde, Qinhuangdao, Baoding, and Zhangjiakou. O3 pollution in summer was the most severe with an average concentration of 134.5 μg/m3. In summer, O3 concentrations in 87.7% of the grids were more than 100 μg/m3. In contrast, winter was the cleanest season in the BTH region, with an average concentration of 51.1 μg/m3.

Exposure to ambient air pollution is associated with an increased risk of menstrual disorders and infertility. This study examined the relationships between the levels and duration of air pollution exposure and the risk of polycystic ovarian syndrome (PCOS) using Korean population-based cohort data (2015–2019). Real-time data on PM10, PM2.5, O3, CO, SO2, and NO2 were provided by the Korean Ministry of Environment. The average monthly air pollutant concentration from 1 January 2014 to 31 December 2018 was analyzed. To assess individual-level exposure to air pollutants, a spatial prediction model and an area-averaging approach were used. In total, 237,582 PCOS cases were analyzed. The annual age-adjusted PCOS incidence was 6.70, 8.28, 9.73, 11.58, and 11.97% from 2015–2019, respectively. The PCOS risk increased 1.29–1.32, 1.43–1.52, and 1.32-fold following exposure to the 2-year and 3-year average levels of PM2.5, O3, and NO2, respectively, compared to their 1-year average levels. The PCOS risk increased 1.75-fold (95% confidence interval: 1.66–1.85) in the fourth-quartile for the NO2 level. Increased SO2 and CO levels in the second- and third-quartiles were also associated with an increased PCOS risk. Exposure to air pollutants thus increased the risk for PCOS in the Korean population.

There has been proliferation of mobile phone base station towers in recent years due to an expansion of mobile telephone networks. This has been accompanied by an increase in the community concern about possible radiation exposure due to the radio frequency (RF) radiation emissions from antennae mounted on the base station towers. This work presents RF measurements and information on the levels at selected markets in Ibadan, Nigeria. The highest RF power density of 499.6 μW/m2 obtained at Global System for Mobile Communication (GSM) 1800 band occurred at Apete market. The lowest RF power density of 0.1 μW/m2 was also obtained at Alesinloye for GSM 1800, Dugbe, and Ogunpa for GSM 900; at this point of measurement, the base transceiver station was not in the line of sight. The measured RF levels were compared with the maximum permissible limit for nonoccupational exposure with respect to the Radiocommunications (Electromagnetic Radiation – Human Exposure) Standard 1999 which specifies a maximum nonoccupational exposure limit of 2 W/m2 (equivalent to 200 μW/cm2) at relevant base station frequencies. The results showed that the RF exposure levels were several orders of magnitude below the maximum permissible limits around the environments of the major markets in the city of Ibadan.

Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years.

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.

Abstract Introduction We examined the correlation between the results of in vitro and in vivo chromosomal damage tests by using in-house data of 18 pharmaceutical candidates that showed positive results in the in vitro chromosomal aberration or micronucleus test using CHL/IU cells, and quantitatively analyzed them especially in regard to exposure levels of the compounds. Findings Eight compounds showed that the exposure levels [maximum plasma concentration (Cmax) and AUC0-24h] were comparable with or higher than the in vitro exposure levels [the lowest effective (positive) concentration (LEC) and AUCvitro = LEC (μg/mL) × treatment time (h)]. Among them, 3 compounds were positive in the in vivo rodent micronucleus assays using bone marrow cells. For 2 compounds, cytotoxicity might produce false-positive results in the in vitro tests. One compound showed in vitro positive results only in the condition with S9 mix which indicated sufficient concentration of unidentified active metabolite(s) might not reach the bone marrow to induce micronuclei. Conclusion These facts suggested that the in vivo exposure levels being equal to or higher than the in vitro exposure levels might be an important factor to detect in vivo chromosomal damage induced by test chemicals.

Introduction: The present study was conducted to obtain State diagnostic reference levels (DRLs) of five routine computed tomography (CT) examinations from two CT centers in Ondo State and to identify factors responsible for dose variation and escalation in these CT centers. Material and Methods: Acquisition parameters and CT dose indices were collected from the storage drives of the two CT centers namely Federal Medical Centre, Owo and Trauma Center, Ondo, Ondo State, Nigeria, for six months on electronic spreadsheets for cranial, sinus, chest, abdomen and pelvis examinations. In addition, dose indices for multiphase examinations were collected to analyze chest and abdominal doses. Wilcoxon rank-sum test was used to assess variations in dose distributions of the two health institutions. Results: The following diagnostic reference levels (DRLs) were obtained at 91 mGy; 1943 mGy.cm, 69 mGy; 1159 mGy.cm, 45 mGy; 1064 mGy.cm, 50 mGy; 2545 mGy.cm and 26 mGy; 622 mGy.cm in cranial, sinus, chest, abdomen and pelvis examinations respectively. Conclusion: Estimated State DRLs exceed national and other DRLs indicating that there is a need to improve the quality of CT-examination for a better benefit to risk ratio. However, benchmarking DRLs to median dose levels (Achievable dose levels) instead of the upper quartile will be a good starting point in achieving the optimal dose level. [ABSTRACT FROM AUTHOR]

Occupational noise exposure is the most prominent problem in industrial enterprises in Jiangsu Province. Since 2019, China has established the National Surveillance System for Occupational Hazards in the workplace to grasp the current occupational hazards in critical industries, including occupational noise. According to the Work Plan for Surveillance of Occupational Hazards in the Workplace (2022) issued by the National Health Commission of the People's Republic of China, the noise exposure level of 3,142 enterprises in our province was monitored, the median and interquartile range (IQR) were calculated, and the distribution of noise exposure level was described by industry classification, enterprise-scale and ownership type of the enterprise. The railway, shipping, aerospace, and other transportation equipment manufacturing industries exhibited the highest proportion (42.9%) of individual noise exposure levels exceeding 85 dB(A), followed by the motor vehicles manufacturing industry (36.4%). The proportion of individual noise exposure levels exceeding 85 dB(A) was higher in medium and small enterprises, with rates of 28.1 and 28.6%, respectively. The highest proportion of personal noise exposure levels exceeding 85 dB(A) was observed in Hong Kong, Macao and Taiwan investment enterprises (37.5%), followed by incorporated companies (34.6%) and limited liability companies (28.1%), the lowest was state-owned enterprises(15.5%). The areas with excessive noise are primarily concentrated in grinding, welding, machining, cutting, and other related operations, accounting for 61.2% of the total. Among these operations, grinding accounts for 29.8%. The highest environmental noise and individual noise intensity were found in sandblasting and grinding positions, with individual noise intensities of 115.5 dB(A) and 108.4 dB(A), respectively. The noise exposure risk is so high that cannot be ignored in the manufacturing industry, especially in Hong Kong, Macao, and Taiwan investment enterprises, incorporated companies and medium and small enterprises., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhang, Wang, Wang and Zhang.)

Urban traffic is closely related to the daily life of the public,and air pollution in the traffic microenvironment has become a public health problem that cannot be ignored.This paper reviews the comparative studies of air pollutant exposure levels among different modes of transportation in multiple cities in China.By comparing the exposure levels of pollutants among different modes of transportation,this paper provides a reference for protecting the health of the public in daily transportation and selecting targeted control measures.

To explore the exposure level of pesticides and veterinary drugs in an aquaculture environment and its impact on the ecological environment, this study took the aquaculture environment in Shanghai as an example, and samples of water, sediment, and inputs from 40 major aquaculture farms were collected from July to September 2022. The types and contents of pesticides and veterinary drugs were screened using high-performance liquid chromatography-electrostatic field orbital ion trap mass spectrometry, and the risk quotient (RQ) method was used to assess the ecological risk of pesticide contamination in water and sediment. The results showed that 13 drugs were screened out from 204 samples (72 samples of water, 72 samples of mud, and 60 samples of input), namely, chlorpromazine, carbendazim, thiophanate, diazepam, florfenicol, simazine, amantidine, diazepam, trimethoprim, ciprofloxacin, ofloxacin, mebendazole, and enrofloxacin. Among them, 12 species were found in water samples with concentrations ranging from 0.016 μg·L -1 to 2.084 μg·L -1 . The concentrations of seven species in the mud samples ranged from 0.018 μg·kg -1 to 23.101 μg·kg -1 . The results showed that there were four types of inputs, ranging from 1.979 μg·kg -1 to 101.940 μg·kg -1 . Seven drugs were found in both water and sediment. The risk quotient (RQ) results showed that there were some high and middle risks in both water and sediment samples of aquaculture farms, and the ecological risks of carbendazim were the highest in both water and sediment samples of aquaculture farms; the RQ values were 3.848 and 1.580, respectively, indicating high risk. It is suggested to strengthen the control and management of exogenous pesticides and veterinary drugs in aquaculture environments to protect the ecosystem health of the aquaculture environment.

There has been proliferation of mobile phone base station towers in recent years due to an expansion of mobile telephone networks. This has been accompanied by an increase in the community concern about possible radiation exposure due to the radio frequency (RF) radiation emissions from antennae mounted on the base station towers. This work presents RF measurements and information on the levels at selected markets in Ibadan, Nigeria. The highest RF power density of 499.6 μW/m2 obtained at Global System for Mobile Communication (GSM) 1800 band occurred at Apete market. The lowest RF power density of 0.1 μW/m2 was also obtained at Alesinloye for GSM 1800, Dugbe, and Ogunpa for GSM 900; at this point of measurement, the base transceiver station was not in the line of sight. The measured RF levels were compared with the maximum permissible limit for nonoccupational exposure with respect to the Radiocommunications (Electromagnetic Radiation – Human Exposure) Standard 1999 which specifies a maximum nonoccupational exposure limit of 2 W/m2 (equivalent to 200 μW/cm2) at relevant base station frequencies. The results showed that the RF exposure levels were several orders of magnitude below the maximum permissible limits around the environments of the major markets in the city of Ibadan. [ABSTRACT FROM AUTHOR]