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Brain connectivity of individuals with autism spectrum disorders (ASD) is heterogenous, as are the behavioral manifestations. The current study investigated brain-behavior relationships in the context of social skills and executive function profiles with data from the Autism Brain Imaging Database Exchange II. We calculated connectivity measures from diffusion tensor imaging using Bayesian estimation and probabilistic tractography. Subsequently, we performed structural equation modeling by regressing three latent factors, yielded from an exploratory factor analysis, onto total default mode network (DMN) connectivity. Both social regulation processing and self-directed cognitive processing factors moderately, negatively correlated with total DMN connectivity. Our findings indicate social regulation processing difficulties in youth with ASD may be attributable to impaired connectivity between the anterior and posterior DMN., Author(s): Jessica Blume [sup.1] , Chanaka Kahathuduwa [sup.2] , Ann Mastergeorge [sup.1] Author Affiliations: (1) grid.264784.b, 0000 0001 2186 7496, Department of Human Development and Family Sciences, Texas Tech University, [...]

The present study evaluated the hypothesis that the strength of the relationship between executive function (EF) and repetitive behaviors and restricted interests (RBRI) symptomatology is moderated by the degree to which concurrent demands are placed on multiple aspects of EF. An eye movement task was used to evaluate inhibition and task switching ability (both together and in isolation) in a sample of 22 children with autism spectrum disorder (ASD). The Repetitive Behavior Scale-Revised (RBS-R) was used to assess the severity of RBRI symptoms. Results provide preliminary support for the aforementioned hypothesis. RBS-R scores were significantly correlated with task performance when simultaneous demands were placed on switching and inhibition; however, no such relationship was found for inhibition-only or switching-only task conditions., Author(s): Mackenzie N. Cissne [sup.1] , Lindsay E. Kester [sup.1] , Amanda J. Moffitt Gunn [sup.2] [sup.3] , Kimberly E. Bodner [sup.4] [sup.5] , Judith H. Miles [sup.2] [sup.6] , [...]

The main objective of the present study was to examine the direct and indirect relations between reading deficits, executive functions, and social adjustment problems in a sample of 210 adolescents. Results demonstrated significant positive correlations between reading deficits, executive function deficits, and social adjustment problems. Furthermore, the findings from two multimethation models indicated that, of three behavioral regulation deficits, inhibition, and, of five metacognitive deficits, initiate and working memory were significant methators of the reading deficit-social adjustment problem association. We conclude that specific executive function deficits explain the association between reading deficits and social adjustment problems. Implications of the current findings are discussed along with suggestions for interventions to improve reading abilities and executive functions to make adolescents better able to adjust in their social context. KEYWORDS: reading deficits, behavioral regulation, metacognition, executive functions, social adjustment problems, Reading deficits are a group of heterogeneous developmental conditions that are characterized primarily by poor comprehension and inefficient phonological processing. Commonly, reading deficits are explained in terms of difficulties in [...]

Executive function (EF), the set of cognitive processes that govern goal-directed behavior, varies within developmental samples and clinical populations. Here, we perform a conceptual replication of prior work (Dajani et al. in Sci Rep 6:36566, 2016) in an independent sample of typically developing children (n = 183) and children with autism spectrum disorder (n = 104). Consistent with previous work, the latent profile analysis of parent-report EF measures provided evidence for three EF classes, which exhibited differential proportions of diagnostic groups. Additionally, children in the impaired EF group exhibited greater levels of social impairment. These results highlight the heterogeneity of EF ability among clinical and non-clinical populations and the link between EF and social abilities., Author(s): Adriana C. Baez [sup.1] , Dina R. Dajani [sup.1] , Willa Voorhies [sup.1] [sup.2] , Meaghan V. Parladé [sup.1] , Michael Alessandri [sup.1] , Jennifer C. Britton [sup.1] , [...]

Performance on the task-switching paradigm is greatly affected by the amount of conflict between tasks. Compared to adults, children appear to be particularly influenced by this conflict, and this suggests that the ability to resolve interference between tasks improves with age. The authors used the task-switching paradigm to investigate how this ability develops in mid-childhood. Experiment 1 compared the ability of 5- to 8-year-olds and of 9- to 11-year-olds to switch between decisions about the color and shape of an object. The 5- to 8-year-olds were slower to switch task and experienced more interference from the irrelevant task than did the 9- to 11-year-olds, which suggests a developmental improvement in resolving conflict between tasks during mid-childhood. In Experiment 2, the influence of stimulus and response interference at different ages was examined by separating the color and shape dimensions of the stimulus and reducing overlap between responses. The results support the development of conflict resolution in task switching during mid-childhood. They also revealed that a complex interplay of factors, including the tasks used and previous experience with the task, affected children's shifting performance. Keywords: executive function, task switching, development, congruence

Purpose: There is little empirical translation of multi-modal cognitive activity programs in 'real-world' community-based settings. This study sought to demonstrate in a short-term pilot randomized trial that such an activity program improves components of cognition critical to independent function among sedentary older adults at greatest risk. Design and Methods: We randomized 149 older adults to Experience Corps[R] (EC) or a wait-list control arm. Participants randomized to EC trained in teams to help elementary school children with reading achievement, library support, and classroom behavior for 15 hr/week during an academic year. We compared baseline and follow-up assessments of memory, executive function (EF), and psychomotor speed at 4 to 8 months by intervention arm, adjusting for exposure duration. We observed a range of EF abilities at baseline and stratified analyses according to the presence of baseline impairment using established norms. Results: Overall, EC participants tended to show improvements in EF and memory relative to matched controls (ps < .10). EC participants with impaired baseline EF showed the greatest improvements, between 44% and 51% in EF and memory at follow-up, compared to declines among impaired-EF controls (ps < .05). Implications: Short-term participation in this community-based program designed to increase cognitive and physical activity in a social, real-world setting may train memory and, particularly, executive functions important to functional independence. This community-based program represents one potentially effective model to bring high doses of sustainable cognitive exercise to the greatest proportion of older adults, particularly those sedentary individuals at elevated risk for health disparities. Key Words: Cognitive activity, Executive dysfunction, Activity intervention, Health disparities, Community-Based