Search

Your search keyword '"Ewend, Matthew G."' showing total 315 results
Start Over Author "Ewend, Matthew G."
315 results on '"Ewend, Matthew G."'

2. Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D’Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Brain Disorders, Brain Cancer, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Rare Diseases, Neurosciences, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Glioblastoma, Temozolomide, Prospective Studies, Brain Neoplasms, Recurrence, Dendritic Cells, Vaccination, Public Health and Health Services, Oncology and carcinogenesis
Abstract

ImportanceGlioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.ObjectiveTo investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.Design, setting, and participantsThis phase 3, prospective, externally controlled nonrandomized trial compared overall survival (OS) in patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) treated with DCVax-L plus SOC vs contemporaneous matched external control patients treated with SOC. This international, multicenter trial was conducted at 94 sites in 4 countries from August 2007 to November 2015. Data analysis was conducted from October 2020 to September 2021.InterventionsThe active treatment was DCVax-L plus SOC temozolomide. The nGBM external control patients received SOC temozolomide and placebo; the rGBM external controls received approved rGBM therapies.Main outcomes and measuresThe primary and secondary end points compared overall survival (OS) in nGBM and rGBM, respectively, with contemporaneous matched external control populations from the control groups of other formal randomized clinical trials.ResultsA total of 331 patients were enrolled in the trial, with 232 randomized to the DCVax-L group and 99 to the placebo group. Median OS (mOS) for the 232 patients with nGBM receiving DCVax-L was 19.3 (95% CI, 17.5-21.3) months from randomization (22.4 months from surgery) vs 16.5 (95% CI, 16.0-17.5) months from randomization in control patients (HR = 0.80; 98% CI, 0.00-0.94; P = .002). Survival at 48 months from randomization was 15.7% vs 9.9%, and at 60 months, it was 13.0% vs 5.7%. For 64 patients with rGBM receiving DCVax-L, mOS was 13.2 (95% CI, 9.7-16.8) months from relapse vs 7.8 (95% CI, 7.2-8.2) months among control patients (HR, 0.58; 98% CI, 0.00-0.76; P

Published
2023

3. First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Tran, David D, Campian, Jian L, Trusheim, John E, Cobbs, Charles S, Heth, Jason A, Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D, Iwamoto, Fabio M, Dropcho, Edward J, Moshel, Yaron A, Walter, Kevin A, Pillainayagam, Clement P, Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A, Bota, Daniela A, Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A, Lillehei, Kevin O, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R, Brenner, Andrew J, Brem, Steven, Ewend, Matthew G, Khagi, Simon, Portnow, Jana, Kim, Lyndon J, Loudon, William G, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E, Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P, Duma, Christopher, Etame, Arnold B, Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S, New, Pamela Z, Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J, Tse, Victor, Green, Richard M, Villano, John L, Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P, Maida, Anthony E, Prins, Robert M, Cloughesy, Timothy F, Mulholland, Paul, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Brain Cancer, Neurosciences, Immunization, Clinical Research, Cancer, Brain Disorders, Rare Diseases, Patient Safety, Prevention, Vaccine Related, Orphan Drug, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Brain Neoplasms, Cancer Vaccines, Dendritic Cells, Endpoint Determination, Female, Glioblastoma, Humans, Male, Middle Aged, Prognosis, Survival Analysis, Treatment Outcome, Young Adult, Immunotherapy, Dendritic cell, Vaccine, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundStandard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard therapy for newly diagnosed glioblastoma.MethodsAfter surgery and chemoradiotherapy, patients were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or temozolomide and placebo (n = 99). Following recurrence, all patients were allowed to receive DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); the secondary endpoint was overall survival (OS).ResultsFor the intent-to-treat (ITT) population (n = 331), median OS (mOS) was 23.1 months from surgery. Because of the cross-over trial design, nearly 90% of the ITT population received DCVax-L. For patients with methylated MGMT (n = 131), mOS was 34.7 months from surgery, with a 3-year survival of 46.4%. As of this analysis, 223 patients are ≥ 30 months past their surgery date; 67 of these (30.0%) have lived ≥ 30 months and have a Kaplan-Meier (KM)-derived mOS of 46.5 months. 182 patients are ≥ 36 months past surgery; 44 of these (24.2%) have lived ≥ 36 months and have a KM-derived mOS of 88.2 months. A population of extended survivors (n = 100) with mOS of 40.5 months, not explained by known prognostic factors, will be analyzed further. Only 2.1% of ITT patients (n = 7) had a grade 3 or 4 adverse event that was deemed at least possibly related to the vaccine. Overall adverse events with DCVax were comparable to standard therapy alone.ConclusionsAddition of DCVax-L to standard therapy is feasible and safe in glioblastoma patients, and may extend survival. Trial registration Funded by Northwest Biotherapeutics; Clinicaltrials.gov number: NCT00045968; https://clinicaltrials.gov/ct2/show/NCT00045968?term=NCT00045968&rank=1 ; initially registered 19 September 2002.

Published
2018

4. Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Tran, David D, Campian, Jian L, Trusheim, John E, Cobbs, Charles S, Heth, Jason A, Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D, Iwamoto, Fabio M, Dropcho, Edward J, Moshel, Yaron A, Walter, Kevin A, Pillainayagam, Clement P, Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A, Bota, Daniela A, Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A, Lillehei, Kevin O, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R, Brenner, Andrew J, Brem, Steven, Ewend, Matthew G, Khagi, Simon, Portnow, Jana, Kim, Lyndon J, Loudon, William G, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E, Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P, Duma, Christopher, Etame, Arnold B, Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S, New, Pamela Z, Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J, Tse, Victor, Green, Richard M, Villano, John L, Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P, Maida, Anthony E, Prins, Robert M, Cloughesy, Timothy F, Mulholland, Paul, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Neurosciences, Brain Disorders, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section.

Published
2018

5. 3 Nasal Flaps and Reconstruction

Author

Klatt-Cromwell, Cristine, Thorp, Brian, Ebert, Charles S., Jr, Sasaki-Adams, Deanna, Ewend, Matthew G., Zanation, Adam M., Evans, James J., editor, Kenning, Tyler J., editor, Farrell, Christopher, editor, and Kshettry, Varun R., editor

Published
2019
Full Text
View/download PDF

8. Supplementary Figure and Data from Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair

Author

Lu, Yanxin, primary, Kwintkiewicz, Jakub, primary, Liu, Yang, primary, Tech, Katherine, primary, Frady, Lauren N., primary, Su, Yu-Ting, primary, Bautista, Wendy, primary, Moon, Seog In, primary, MacDonald, Jeffrey, primary, Ewend, Matthew G., primary, Gilbert, Mark R., primary, Yang, Chunzhang, primary, and Wu, Jing, primary

Published
2023
Full Text
View/download PDF

9. Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial.

Author

Liau, Linda M, Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D'Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, Bosch, Marnix L, Liau, Linda M, Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D'Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, and Bosch, Marnix L

Abstract

ImportanceGlioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.ObjectiveTo investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.Design, setting, and participantsThis phase 3, prospective, externally controlled nonrandomized trial compared overall survival (OS) in patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) treated with DCVax-L plus SOC vs contemporaneous matched external control patients treated with SOC. This international, multicenter trial was conducted at 94 sites in 4 countries from August 2007 to November 2015. Data analysis was conducted from October 2020 to September 2021.InterventionsThe active treatment was DCVax-L plus SOC temozolomide. The nGBM external control patients received SOC temozolomide and placebo; the rGBM external controls received approved rGBM therapies.Main outcomes and measuresThe primary and secondary end points compared overall survival (OS) in nGBM and rGBM, respectively, with contemporaneous matched external control populations from the control groups of other formal randomized clinical trials.ResultsA total of 331 patients were enrolled in the trial, with 232 randomized to the DCVax-L group and 99 to the placebo group. Median OS (mOS) for the 232 patients with nGBM receiving DCVax-L was 19.3 (95% CI, 17.5-21.3) months from randomization (22.4 months from surgery) vs 16.5 (95% CI, 16.0-17.5) months from randomization in control patients (HR = 0.80; 98% CI, 0.00-0.94; P = .002). Survival at 48 months from randomization was 15.7% vs 9.9%, and at 60 months, it was 13.0% vs 5.7%. For 64 patients with rGBM receiving DCVax-L, mOS was 13.2 (95% CI, 9.7-16.8) months from relapse vs 7.8 (95% CI, 7.2-8.2) months among control patients (HR, 0.58; 98% CI, 0.00-0.76; P < .001). Survival at 24 and 30 months after rec

Published
2023

10. List of Contributors

Author

Rudmik, Luke, primary, Barnes, Martyn L., additional, Batra, Pete S., additional, Brasnu, Daniel F., additional, Breuskin, Ingrid, additional, Cates, Daniel J., additional, de Champlain, Katie, additional, Chau, Justin, additional, Conrad, David, additional, DelGaudio, John M., additional, Ebert, Charles S., additional, Ewend, Matthew G., additional, Farhood, Zachary, additional, Hartl, Dana M., additional, Hwang, Euna, additional, Jandali, Danny, additional, Klatt-Cromwell, Cristine N., additional, Levy, Joshua M., additional, Lui, Justin, additional, Luk, Lauren J., additional, Maresh, Alison, additional, Massa, Sean T., additional, Merati, Albert L., additional, Misono, Stephanie, additional, Modi, Vikash K., additional, Quintanilla-Dieck, Lourdes, additional, Randall, Derrick R., additional, Rosbe, Kristina, additional, Sasaki-Adams, Deanna M., additional, Schuman, Theodore A., additional, Shao, Angus, additional, Shindo, Maisie, additional, Spielmann, Patrick M., additional, Stewart, Michael G., additional, Tajudeen, Bobby A., additional, Thorp, Brian D., additional, Tse, Darren, additional, Walen, Scott G., additional, White, Paul S., additional, Wise, Sarah K., additional, and Zanation, Adam M., additional

Published
2018
Full Text
View/download PDF

11. Evidence-Based Practice

Author

Klatt-Cromwell, Cristine N., primary, Schuman, Theodore A., additional, Thorp, Brian D., additional, Ebert, Charles S., additional, Sasaki-Adams, Deanna M., additional, Ewend, Matthew G., additional, and Zanation, Adam M., additional

Published
2018
Full Text
View/download PDF

17. Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer

Author

Bullitt, Elizabeth, Lin, Nancy U., Ewend, Matthew G., Zeng, Donglin, Winer, Eric P., Carey, Lisa A., Smith, J. Keith, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Larsen, Rasmus, editor, Nielsen, Mads, editor, and Sporring, Jon, editor

Published
2006
Full Text
View/download PDF

18. Contributors

Author

Araújo, Érica S.S., primary, Bashashati, Mohammad, additional, Bassi, Shivani, additional, Cirino, Giuseppe, additional, Collichio, Frances A., additional, Davies, Michael A., additional, Duchnowska, Renata, additional, Engelman, Alexander, additional, Esmaeilzadeh, Majid, additional, Ewend, Matthew G., additional, Fine, Robert Lance, additional, Fontanella, Caterina, additional, Forsyth, Peter A., additional, Gandhoke, Gurpreet S., additional, Glitza, Isabella C., additional, Gulati, Anthony Paul, additional, Guo, Jun, additional, Hayat, M.A., additional, Heimberger, Amy, additional, Helseth, Eirik, additional, Hong, Angela M., additional, Ianaro, Angela, additional, Jassem, Jacek, additional, Kavecansky, Juraj, additional, Kee, Damien, additional, Keramati, Mohammad Reza, additional, Khoury, Michael N., additional, Krepischi, Ana C.V., additional, Kwok, Young, additional, Lau, Peter, additional, Lal, Supriya, additional, Leclerc, Estelle, additional, Lee, Carrie B., additional, Long, Georgina V., additional, Lunsford, L. Dade, additional, Lyle, Megan, additional, Mao, Lili, additional, Meling, Torstein R., additional, Missios, Symeon, additional, Monaco, Edward A., additional, Moschos, Stergios J., additional, Nichols, Elizabeth, additional, Niranjan, Ajay, additional, Osa, Etin-Osa, additional, Pavlick, Anna C., additional, Pramio, Dimitrius T., additional, Puglisi, Fabio, additional, Rogne, Siril G., additional, Shivalingam, Brindha, additional, Sulman, Erik P., additional, Svokos, Konstantina, additional, Tanaka, Toshihide, additional, Tarhini, Ahmad A., additional, Thompson, John F., additional, Toms, Steven A., additional, Tran, Nam D., additional, Trembath, Dimitri, additional, Weiss, Sarah A., additional, and Zagar, Timothy M., additional

Published
2016
Full Text
View/download PDF

19. Brain Metastases from Cutaneous Melanoma

Author

Moschos, Stergios J., primary, Trembath, Dimitri, additional, Collichio, Frances A., additional, Lee, Carrie B., additional, Zagar, Timothy M., additional, and Ewend, Matthew G., additional

Published
2016
Full Text
View/download PDF

20. Multidisciplinary Management of Breast Cancer Brain Metastases

Author

Zagar, Timothy M., Van Swearingen, Amanda E.D., Kaidar-Person, Orit, Ewend, Matthew G., and Anders, Carey K.

Subjects
Breast cancer -- Development and progression -- Care and treatment, Levetiracetam, Cancer metastasis -- Development and progression -- Care and treatment, Epidemiology, Radiation (Physics), Anticonvulsants, Cancer patients, Surgery, Neurosurgery, Physicians, Company business management, Health
Abstract

This review summarizes the most up-to-date approach to the multidisciplinary management of patients with breast cancer brain metastases. A brief overview of the epidemiology and biology of breast cancer brain metastasis is provided. The perspectives of radiation oncology, neurosurgery, and medical oncology--and landmark studies from each discipline--are all discussed. We also offer practical tips to help guide the treating physician, including data on antiseizure medications. Finally, we introduce the concept of a multidisciplinary clinic that combines input from medical and radiation oncology, neurosurgery, and support services, which we developed at the University of North Carolina as a coordinated and optimal approach to the management of patients with this complex disease., Introduction Brain metastases are a challenging consequence of advanced cancer. It is estimated that there are over 150,000 cases of brain metastases diagnosed annually across all tumor types.[1] Breast cancer [...]

Published
2016

21. Comparative Outcomes by Surgical Approach in Patients with Malignant Sinonasal Disease.

Author

Lenze, Nicholas R., Quinsey, Carolyn, Sasaki-Adams, Deanna, Ewend, Matthew G., Thorp, Brian D., Ebert Jr., Charles S., and Zanation, Adam M.

Subjects
PARANASAL sinuses, SURGICAL complications, ENDOSCOPIC surgery, SQUAMOUS cell carcinoma, CARCINOMA
Abstract

Objective  There is a paucity of data on comparative outcomes for open versus endoscopic surgery for patients with malignant sinonasal pathology. Most of the available studies are limited by a sample size <100 patients. Design  This is a retrospective cohort study. Setting  The findings of this study come from a single-institution tertiary care center from 2008 to 2019. Participants  In total, 199 patients who underwent surgery for malignant sinonasal disease participated in this study. Main Outcome Measures  The main outcome measures were perioperative complications and reoperation. Results  Patients in our sample had a mean age of 59.7 years (SD, 20.4). In total, 62% were male and 72% were white. An endoscopic-only approach was used in 41% of patients and an open or combined approach in 59% of patients. Squamous cell carcinoma was the most common pathology (43.0%), followed by sarcoma (9.5%), skin cancer (6.5%), sinonasal undifferentiated carcinoma (6.5%), and adenocarcinoma (5.5%). The all-cause complication rate was 14.6%. Patients with an open resection had a higher rate of intraoperative complications (5.9 vs. 0%; p  = 0.043), postoperative complications (19.5 vs. 3.7%; p  = 0.001), and all-cause complications (21.0 vs. 3.7%; p  < 0.001). The likelihood of early reoperation (<6 months) or late reoperation (>6 months) did not significantly differ by surgical approach (p  = 1.000 and 0.741, respectively). Conclusion  The endoscopic approach for resection of malignant sinonasal disease is viable for select patients and may be associated with a favorable complication rate compared with the open approach. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

23. Brain Tumor Microenvironment and Angiogenesis in Melanoma Brain Metastases

Author

Trembath, Dimitri G., primary, Davis, Eric S., additional, Rao, Shanti, additional, Bradler, Evan, additional, Saada, Angelica F., additional, Midkiff, Bentley R., additional, Snavely, Anna C., additional, Ewend, Matthew G., additional, Collichio, Frances A., additional, Lee, Carrie B., additional, Karachaliou, Georgia-Sofia, additional, Ayvali, Fatih, additional, Ollila, David W., additional, Krauze, Michal T., additional, Kirkwood, John M., additional, Vincent, Benjamin G., additional, Nikolaishvilli-Feinberg, Nana, additional, and Moschos, Stergios J., additional

Published
2021
Full Text
View/download PDF

28. Contributors

Author

Aarabi, Bizhan, primary, Abbott, Rick, additional, Abdulrauf, Saleem I., additional, Acosta, Frank L., additional, Adler, John R., additional, Agazaryan, Nzhde, additional, Aghi, Manish, additional, Ahn, Edward S., additional, Alaraj, Ali, additional, Albert, Gregory W., additional, Albright, Leland, additional, Albuquerque, Felipe C., additional, Alden, Tord D., additional, Alexander, Michael J., additional, Alexandrov, Andrei V., additional, Al-Mefty, Ossama, additional, Alterman, Ron L., additional, Álvarez, Lázaro, additional, Amankulor, Nduka M., additional, Amenta, Peter S., additional, Ames, Christopher P., additional, Amin-Hanjani, Sepideh, additional, Ammirati, Mario, additional, Anderson, Carryn, additional, Anderson, Richard C.E., additional, Anderson, William S., additional, Angevine, Peter D., additional, Arif, Hiba, additional, Arle, Jeffrey E., additional, Armonda, Rocco, additional, Arnold, Paul M., additional, Asadi-Moghaddam, Kaveh, additional, Asghar, Ferhan A., additional, Ashley, William W., additional, Aydin, Sabri, additional, Aygun, Nafi, additional, Baehring, Joachim M., additional, Bagley, Jacob H., additional, Bahgat, Diaa, additional, Bailes, Julian E., additional, Ball, Jonathon R., additional, Baltuch, Gordon H., additional, Bambakidis, Nicholas C., additional, Baraban, Scott C., additional, Barani, Igor J., additional, Barbaro, Nicholas M., additional, Barker, Frederick G., additional, Barnett, Gene H., additional, Barnwell, Stanley L., additional, Barone, Constance M., additional, Barrow, Daniel L., additional, Bartolomei, Fabrice, additional, Bartolomei, Juan, additional, Batchelor, Tracy T., additional, Batjer, H. Hunt, additional, Bauer, Andrew M., additional, Bauman, Joel A., additional, Baumann, Thomas K., additional, Baumgartner, James E., additional, Bayouth, John, additional, Beaumont, Andrew, additional, Bederson, Joshua B., additional, Beisse, Rudolf, additional, Bell, Randy S., additional, Belzberg, Allan, additional, Benabid, Alim Louis, additional, Benarroch, Eduardo E., additional, Benazzouz, Abdelhamid, additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berenstein, Alejandro, additional, Berger, Mitchel S., additional, Bergsneider, Marvin, additional, Bertalanffy, Helmut, additional, Bhalla, Tarun, additional, Bidros, Dani S., additional, Biller, José, additional, Bilsky, Mark H., additional, Binder, Devin K., additional, Bingaman, William, additional, Birch, Rolfe, additional, Bishop, Allen T., additional, Black, Peter M., additional, Blount, Jeffrey P., additional, Blumbergs, Peter C., additional, Bohman, Leif-Erik, additional, Boomsaad, Zackary E., additional, Boop, Frederick A., additional, Bou-Haidar, Pascal, additional, Boué, Daniel R., additional, Bourgeois, Blaise F.D., additional, Bowman, Robin M., additional, Bozinov, Oliver, additional, Bramlett, Helen M., additional, Brem, Henry, additional, Brem, Steven, additional, Britz, Gavin W., additional, Brockmeyer, Douglas L., additional, Brooks, David J., additional, Browd, Samuel R., additional, Brown, Paul D., additional, Brown, Robert D., additional, Bruce, Jeffrey N., additional, Brunstrom-Hernandez, Janice E., additional, Buatti, John, additional, Bullock, M. Ross, additional, Burchiel, Kim J., additional, Burger, Peter C., additional, Bussière, Marc R., additional, Bydon, Mohamad, additional, Byrne, Richard W., additional, Calcagnotto, Maria Elisa, additional, Campbell, Victoria A., additional, Campbell, William, additional, Cannon, George M., additional, Caragine, Louis P., additional, Carson, Benjamin S., additional, Cascino, Gregory D., additional, Cascio, Ethan, additional, Castinetti, Frédéric, additional, Cawley, C. Michael, additional, Cetas, Justin S., additional, Chabardès, Stéphan, additional, Chang, Edward F., additional, Chang, Eric C., additional, Chang, Eric L., additional, Chang, Steven D., additional, Chang, Steven W., additional, Chang, Susan M., additional, Chao, Kevin, additional, Chapman, Paul H., additional, Charbel, Fady T., additional, Chauvel, Patrick, additional, Chen, Grace, additional, Cheng, Boyle C., additional, Cheng, Joseph S., additional, Chern, Joshua J., additional, Chiocca, E. Antonio, additional, Choutka, Ondrej, additional, Chowdhry, Shakeel A., additional, Christian, Cindy W., additional, Chuang, Kathy, additional, Claassen, Jan, additional, Clatterbuck, Richard E., additional, Claus, Elizabeth B., additional, Cleary, Daniel R., additional, Coffey, Robert J., additional, Cohen, Alan R., additional, Cole, Andrew J., additional, Connolly, E. Sander, additional, Connolly, Patrick J., additional, Copay, Anne G., additional, Coppens, Jeroen R., additional, Corbett, James J., additional, Corcos, Daniel M., additional, Coric, Domagoj, additional, Cosgrove, Garth Rees, additional, Couldwell, William T., additional, Craig, Stirling, additional, Crawford, Neil R., additional, Crino, Peter B., additional, Crowley, R. Webster, additional, Curt, Bradford A., additional, Czosnyka, Marek, additional, Czosnyka, Zofia, additional, Dadashev, Vladimir Y., additional, Dailey, Andrew T., additional, Danan, Deepa, additional, Danish, Shabbar F., additional, Dashti, Shervin R., additional, David, Carlos A., additional, David, David J., additional, Day, Arthur L., additional, De Salles, Antonio A.F., additional, Dehdashti, Amir R., additional, Del Brutto, Oscar H., additional, Delashaw, Johnny B., additional, Delman, Bradley, additional, DeLong, Mahlon R., additional, DeMonte, Franco, additional, Dhall, Sanjay S., additional, Dias, Mark S., additional, Dickman, Curtis A., additional, Dietrich, W. Dalton, additional, DiLuna, Michael L., additional, Di Meco, Francesco, additional, Dirks, Peter, additional, Dixon, C. Edward, additional, Donoghue, Jacob A., additional, Dorward, Ian G., additional, Doshi, Amish H., additional, Drake, James, additional, Drzymalski, Dan, additional, Du, Rose, additional, Ducruet, Andrew, additional, Duhaime, Ann-Christine, additional, Dumont, Aaron S., additional, Duntsch, Christopher D., additional, Dusick, Joshua R., additional, Dyve, Suzan, additional, Eberwine, James, additional, Eboli, Paula, additional, Ecker, Robert D., additional, Edwards, Richard J., additional, Eichler, Marc E., additional, Engel, Doortje C., additional, Epstein, Nancy E., additional, Ewend, Matthew G., additional, Farhat, Hamad, additional, Farrell, Christopher J., additional, Fehlings, Michael G., additional, Feiz-Erfan, Iman, additional, Feldstein, Neil A., additional, Fessler, Richard G., additional, Figueroa, Juan J., additional, Filler, Aaron G., additional, Findlay, J. Max, additional, Finn, Michael A., additional, Fiorella, David J., additional, Fisher, James L., additional, Fisher, Robert S., additional, Flamm, Eugene S., additional, Fleck, James D., additional, Flemming, Kelly D., additional, Flickinger, John C., additional, Flores-Sarnat, Laura, additional, Follett, Kenneth A., additional, Foote, Kelly D., additional, Fourney, Daryl R., additional, Fraix, Valerie, additional, Frazier, James L., additional, Fried, Itzhak, additional, Friedman, Allan H., additional, Friedman, William A., additional, Friehs, Gerhard M., additional, Fry, Donald E., additional, Fuller, Gregory N., additional, Garcia, Hector H., additional, Gardner, Paul A., additional, Garrett, Mark, additional, Garton, Hugh, additional, Gavin, Cormac G., additional, Gean, Alisa D., additional, Gennarelli, Thomas A., additional, Gerganov, Venelin, additional, Germanwala, Anand V., additional, Gerosa, Massimo, additional, Gerstner, Elizabeth R., additional, Gerszten, Peter C., additional, Ghatan, Saadi, additional, Ghostine, Samer, additional, Giannotta, Steven, additional, Gigante, Paul R., additional, Gilliam, Frank, additional, Gilmer-Hill, Holly, additional, Gjedde, Albert, additional, Glick, Roberta P., additional, Gokaslan, Ziya L., additional, Gologorsky, Yakov, additional, Golshani, Kiarash, additional, Gonzalez, Nestor R., additional, Goodrich, James Tait, additional, Gordon, Tessa, additional, Gorgulho, Alessandra A., additional, Goumnerova, Liliana C., additional, Grady, M. Sean, additional, Grafman, Jordan, additional, Grand, Sylvie, additional, Grant, Gerald A., additional, Graziano, Gregory P., additional, Greenberg, Benjamin, additional, Guest, James, additional, Guha, Abhijit, additional, Günel, Murat, additional, Gupta, Gaurav, additional, Gupta, Nalin, additional, Guridi, Jorge, additional, Guthrie, Barton L., additional, Haddad, Georges F., additional, Haglund, Michael M., additional, Haid, Regis W., additional, Haines, Stephen J., additional, Hamani, Clement, additional, Hamilton, Bronwyn E., additional, Hamilton, D. Kojo, additional, Hankinson, Todd C., additional, Happel, Leo T., additional, Haq, Ihtsham Ul, additional, Haque, Raqeeb, additional, Harbaugh, Robert E., additional, Harraher, Ciara D., additional, Harris, Leo, additional, Harrop, James S., additional, Hassaneen, Wael, additional, Hawkins, Cynthia, additional, Hawryluk, Gregory W.J., additional, Haynes, Neal G., additional, Heary, Robert F., additional, Heimberger, Amy B., additional, Heinricher, Mary M., additional, Hemmen, Thomas M., additional, Henderson, Jaimie M., additional, Heros, Roberto C., additional, Herrup, Karl, additional, Hervey-Jumper, Shawn L., additional, Heuer, Gregory G., additional, Hirsch, Lawrence J., additional, Hirschl, Robert, additional, Hoh, Brian L., additional, Hoh, Daniel J., additional, Holland, Eric C., additional, Holtzheimer, Paul E., additional, Hopkins, L. Nelson, additional, Horner, Philip J., additional, Hovda, David A., additional, Howard, Matthew A., additional, Hsieh, Patrick, additional, Hu, Yin C., additional, Hua, Sherwin E., additional, Huang, Jason H., additional, Huang, Judy, additional, Hughes, Samuel A., additional, Huisman, Thierry A.G.M., additional, Hunt, Matthew A., additional, Hurlbert, R. John, additional, Hurst, Robert W., additional, Huttner, Anita, additional, Hwang, Steven W., additional, Isaias, Ioannis U., additional, Iskandar, Bermans J., additional, Jacob, Arun, additional, Jaeckle, Kurt A., additional, Jagannathan, Jay, additional, Jakacki, Regina I., additional, Jallo, George I., additional, Jane, John A., additional, Janicki, Ryan, additional, Janigro, Damir, additional, Jeelani, N u Owase, additional, Jellinger, Kurt A., additional, Jenkins, Arthur L., additional, Jernigan, Sarah, additional, Jimenez, David F., additional, Johanson, Conrad E., additional, Johnson, J. Patrick, additional, Johnson, Matthew D., additional, Jones, G. Alexander, additional, Jutla, Rajni K., additional, Kainth, Koijan Singh, additional, Kaiser, Michael G., additional, Kakarla, U. Kumar, additional, Kalfas, Iain H., additional, Kalnins, Aleksandrs Uldis, additional, Kano, Hideyuki, additional, Kanpolat, Yucel, additional, Kanter, Adam S., additional, Karimi, Reza J., additional, Kassam, Amin B., additional, Kaufman, Bruce A., additional, Kaufman, Christian B., additional, Kawasaki, Hiroto, additional, Kelley, Brian C., additional, Kellner, Christopher P., additional, Keong, Nicole C., additional, Kestle, John R.W., additional, Khalessi, Alexander A., additional, Khan, Nadia, additional, Khurana, Vini G., additional, Kim, Daniel H., additional, Kim, Dong Gyu, additional, Kim, Dong H., additional, Kim, Jong Hyun, additional, Kim, Louis J., additional, Kim, Paul K., additional, Kim, Thomas Aquinas, additional, Kim, Won, additional, King, James A.J., additional, Kitagawa, Ryan S., additional, Kitchen, Neil D., additional, Klimo, Paul, additional, Kline, David G., additional, Kobayashi, Kazutaka, additional, Kochanek, Patrick M., additional, Kondziolka, Douglas, additional, Kongkham, Paul N., additional, Koski, Tyler R., additional, Kosztowski, Thomas, additional, Krack, Paul, additional, Krauss, Joachim K., additional, Kraut, Michael A., additional, Krayenbühl, Niklaus, additional, Kretschmer, Thomas, additional, Krishnaney, Ajit, additional, Kuntz, Charles, additional, Kuo, Jeffrey V., additional, Kwon, Brian K., additional, Laack, Nadia N. Issa, additional, Lad, Shivanand P., additional, Ladha, Alim M., additional, Ladouceur, Amos K., additional, Lam, Arthur M., additional, Lang, Frederick F., additional, Lanzino, Giuseppe, additional, Lavine, Sean D., additional, Laws, Edward R., additional, Lawton, Michael T., additional, Laxton, Adrian W., additional, Le, Tuong H., additional, LeBas, Jean François, additional, Lebed, Brett D., additional, Lebow, Richard L., additional, Lee, Amy, additional, Lee, Ian, additional, Lee, Seon-Kyu, additional, Lehmann, Emily, additional, Leiphart, James W., additional, Lekovic, Gregory P., additional, Lenz, Frederick A., additional, Leonard, Jeffrey R., additional, LeRoux, Peter D., additional, Lévêque, Marc, additional, Levi, Allan D., additional, Levy, Elad I., additional, Liau, Linda M., additional, Liauw, Jason, additional, Lichtenbaum, Roger, additional, Lichtor, Terry, additional, Limbrick, David D., additional, Lingsma, Hester, additional, Link, Michael J., additional, Linskey, Mark E., additional, Litt, Brian, additional, Litvack, Zachary N., additional, Liu, James K.C., additional, Liu, Kenneth C., additional, Loeffler, Jay S., additional, Loftus, Christopher M., additional, Lonser, Russell R., additional, Louvi, Angeliki, additional, Lozano, Andres M., additional, Lu, Daniel C., additional, Lukas, Rimas V., additional, Lunsford, L. Dade, additional, Luther, Neal, additional, Lylyk, Pedro, additional, Maas, Andrew I.R., additional, Macdonald, R. Loch, additional, Machado, Andre, additional, Macias, Raul, additional, Maciunas, Robert J., additional, Maddux, Brian N., additional, Magistretti, Pierre, additional, Malessy, Martijn J.A., additional, Malhotra, Neil R., additional, Malone, Donald A., additional, Mamelak, Adam N., additional, Mandigo, Christopher E., additional, Mangano, Francesco T., additional, Maniker, Allen H., additional, Manley, Geoffrey T., additional, Marchac, Daniel, additional, Marmarou, Anthony, additional, Maroon, Joseph C., additional, Marshall, Lawrence F., additional, Martin, Neil A., additional, Martin, Timothy J., additional, Mason, Alexander M., additional, Mathews, Marlon S., additional, Mayberg, Helen S., additional, McAllister, James P., additional, McComb, J. Gordon, additional, McCormick, Paul C., additional, McCutcheon, Ian E., additional, McDermott, Michael W., additional, McDougall, Cameron G., additional, McGehee, Matthew, additional, McIntyre, Cameron C., additional, McKhann, Guy M., additional, McKisic, M. Sean, additional, Meaney, David F., additional, Mehta, Minesh P., additional, Mehta, Vivek, additional, Melega, William P., additional, Menezes, Arnold H., additional, Mertens, Patrick, additional, Meyer, Fredric B., additional, Meyer, Scott A., additional, Meyers, Philip M., additional, Michaelides, Costas, additional, Michaud, Karine, additional, Midha, Rajiv, additional, Miele, Vincent J., additional, Miller, Jonathan, additional, Miller, Matthew L., additional, Miller, Neil R., additional, Mitrofanis, John, additional, Miyashiro, Kevin Y., additional, Mocco, J., additional, Modic, Michael T., additional, Moftakhar, Parham, additional, Mohan, Avinash, additional, Monteith, Stephen J., additional, Morcos, Jacques J., additional, Morgan, Michael, additional, Morris, David E., additional, Moss, S. David, additional, Muizelaar, J. Paul, additional, Mukhida, Karim, additional, Mummaneni, Praveen V., additional, Murad, Gregory J.A., additional, Muraszko, Karin, additional, Mussi, Antônio C.M., additional, Najm, Imad, additional, Nakaji, Peter, additional, Narayanan, Sandra, additional, Newell, David W., additional, Nicholas, M. Kelly, additional, Niimi, Yasunari, additional, Nimjee, Shahid M., additional, Niranjan, Ajay, additional, North, Richard B., additional, Novotny, Josef, additional, Nurmikko, Turo, additional, Nutt, Samuel E., additional, Oakes, W. Jerry, additional, Obeso, José A., additional, Ogden, Alfred T., additional, Ogieglo, Lissa, additional, Ogilvy, Christopher S., additional, Okonkwo, David O., additional, Okun, Michael S., additional, Oldfield, Edward H., additional, Olivi, Alessandro, additional, Olvey, Stephen E., additional, Omahen, David, additional, O'Neill, Brent, additional, Oskouian, Rod J., additional, Owen, Robert, additional, Özduman, Koray, additional, Ozturk, Ali Kemal, additional, Pamir, M. Necmettin, additional, Pang, Dachling, additional, Pardini, Jamie, additional, Parent, Andrew D., additional, Park, T.S., additional, Partington, Michael D., additional, Patel, Aman B., additional, Patil, Parag G., additional, Pavese, Nicola, additional, Penn, Richard D., additional, Perin, Noel I., additional, Persing, John A., additional, Petersen, Erika A., additional, Petraglia, Anthony L., additional, Piallat, Brigitte, additional, Piatt, Joseph H., additional, Pickard, John D., additional, Piepmeier, Joseph M., additional, Pilcher, Webster H., additional, Pineda, José, additional, Pinter, Joseph D., additional, Pisculli, Mary L., additional, Pittman, Thomas, additional, Pollack, Ian F., additional, Pollak, Pierre, additional, Pollock, Bruce E., additional, Ponce, Francisco A., additional, Porter, Alyx B., additional, Porter, Randall W., additional, Post, Kalmon D., additional, Powers, Alexander K., additional, Proctor, Mark R., additional, Prost, Robert W., additional, Pugh, Jeffrey, additional, Quiñones-Hinojosa, Alfredo, additional, Raffel, Corey, additional, Rajpal, Sharad, additional, Rangel-Castilla, Leonardo, additional, Rao, Ganesh, additional, Raslan, Ahmed, additional, Rasmussen, Peter A., additional, Ray, Dibyendu K., additional, Raza, Shaan M., additional, Reames, Davis L., additional, Reddy, Chandan G., additional, Redmond, Andy J., additional, Régis, Jean, additional, Reilly, Peter L., additional, Renier, Dominique, additional, Resnick, Daniel K., additional, Reynolds, Renee, additional, Rezai, Ali R., additional, Rhines, Laurence D., additional, Rhoton, Albert L., additional, Ribalta, Teresa, additional, Richardson, R. Mark, additional, Rigamonti, Daniele, additional, Riggins, Gregory J., additional, Riva-Cambrin, Jay, additional, Rizzo, Paolo, additional, Roberts, David W., additional, Robertson, Claudia, additional, Robinson, Lawrence, additional, Robinson, Shenandoah, additional, Roche, Pierre-Hugues, additional, Rockoff, Mark A., additional, Rodts, Gerald E., additional, Romanelli, Pantaleo, additional, Rosenblum, Mark L., additional, Rosenow, Joshua M., additional, Rosner, Michael K., additional, Rovner, Eric S., additional, Runge-Samuelson, Christina L., additional, Russell, Stephen M., additional, Rutka, James T., additional, Sagher, Oren, additional, St. Clair, Eric G., additional, Samii, Madjid, additional, Sampath, Prakash, additional, Samudrala, Srinath, additional, Sanai, Nader, additional, Sanford, Robert A., additional, Santiago, Paul, additional, Santiago-Sim, Teresa, additional, Sarnat, Harvey B., additional, Sawaya, Raymond, additional, Scheld, W. Michael, additional, Shirzadi, Wouter I., additional, Schiff, Nicholas D., additional, Schirmer, Clemens M., additional, Schlesinger, David, additional, Schmidt, Meic H., additional, Schouten, Joost W., additional, Schramm, Johannes, additional, Schuler, Thomas C., additional, Schuster, James M., additional, Schwartz, Theodore H., additional, Schwartzbaum, Judith A., additional, Schweder, Patrick M., additional, Scott, R. Michael, additional, Seigneuret, Eric, additional, Selden, Nathan R., additional, Selman, Warren R., additional, Shaffrey, Christopher I., additional, Shah, Manish N., additional, Shahlaie, Kiarash, additional, Shapiro, William R., additional, Sharma, Deepak, additional, Sheehan, Jason P., additional, Sheehan, Jonas M., additional, Sherma, Arun K., additional, Shiflett, James M., additional, Shih, Helen A., additional, Shils, Jay L., additional, Shin, Alexander Y., additional, Shirzadi, Ali, additional, Siddiqui, Adnan H., additional, Sindou, Marc, additional, Slavin, Konstantin V., additional, Smith, Edward R., additional, Smith, Justin S., additional, Smith, Yoland, additional, Smyth, Matthew D., additional, Sneed, Penny K., additional, Snyder, Brian J., additional, Snyder, Kenneth V., additional, Solomon, Robert A., additional, Sonntag, Volker K.H., additional, Sørensen, Leif, additional, Soriano, Sulpicio G., additional, Souweidane, Mark M., additional, Spears, Julian, additional, Spencer, David, additional, Spencer, Dennis D., additional, Spetzler, Robert F., additional, Spinner, Robert J., additional, Stacey, Brett R., additional, Stacey, William C., additional, Starke, Robert M., additional, Starr, Philip A., additional, Steinberg, Gary K., additional, Stephens, Frederick L., additional, Stern, Barney J., additional, Stevenson, Charles B., additional, Stiner, Eric, additional, Stone, Scellig, additional, Stroud, Nicole L., additional, Stuart, Robert Morgan, additional, Subach, Brian R., additional, Sugrue, Patrick A., additional, Suki, Dima, additional, Sulaiman, Wale A.R., additional, Surdell, Daniel L., additional, Sutherling, William W., additional, Sutton, Leslie N., additional, Syed, Omar N., additional, Tagliati, Michele, additional, Takagi, Yasushi, additional, Tamargo, Rafael J., additional, Tan, Caroline C., additional, Tandon, Nitin, additional, Tatagiba, Marcos, additional, Taylor, Michael D., additional, Telian, Steven A., additional, Teo, Charles, additional, Tessier, Jeffrey M., additional, Than, Khoi D., additional, Thapar, Kamal, additional, Theodore, Nicholas, additional, Thompson, B. Gregory, additional, Tiel,, Robert, additional, Tihan, Tarik, additional, Tilton, Ann, additional, Timmons, Shelly D., additional, Toledo, Maria, additional, Tomita, Tadanori, additional, Tomycz, Nestor D., additional, Torres, Napoleon, additional, Toussaint, Charles P., additional, Trapp, Bruce D., additional, Traynelis, Vincent C., additional, Tubbs, R. Shane, additional, Tumialán, Luis M., additional, Tunkel, Allan R., additional, Umemura, Atsushi, additional, Vaccaro, Alexander R., additional, van Besien, Koen, additional, Vitek, Jerrold L., additional, Vives, Kenneth P., additional, Vogel, Timothy W., additional, Vogelbaum, Michael A., additional, Vollmer, Dennis G., additional, Von Allmen, Gretchen K., additional, von Eckardstein, Kajetan L., additional, Wackym, P. Ashley, additional, Wainwright, Mark, additional, Waldau, Ben, additional, Walker, Marion L., additional, Wallace, M. Christopher, additional, Walsh, Brian, additional, Wang, Huan, additional, Wang, Michael Y., additional, Wang, Vincent Y., additional, Warnick, Ronald E., additional, Webb, Sharon, additional, Weigel, Ralf, additional, Weil, Robert J., additional, Weingart, Jon D., additional, Weir, Bryce, additional, Weiss, Martin, additional, Weiss, Nirit, additional, Welch, William C., additional, Wellons, John C., additional, Wen, Hung Tzu, additional, Wess, Christian, additional, West, G. Alexander, additional, Wetjen, Nicholas M., additional, Whitmore, Robert G., additional, Whitworth, Louis A., additional, Wichmann, Thomas, additional, Wiemels, Joseph L., additional, Wijdicks, Eelco F.M., additional, Wilberger, Adam C., additional, Wilberger, Jack, additional, Wildrick, David M., additional, Wilson, Jason, additional, Winfree, Christopher J., additional, Winn, H. Richard, additional, Wolfla, Christopher, additional, Wong, Eric T., additional, Wormald, Peter J., additional, Wrensch, Margaret, additional, Wright, Neill M., additional, Wright, Zachary, additional, Yam, David, additional, Yamada, Shinya, additional, Yamada, Yoshiya, additional, Yang, Isaac, additional, Yang, Victor X.D., additional, Yao, Tom, additional, Yen, Chun-Po, additional, Yeoh, H. Kwang, additional, Yonekawa, Yasuhiro, additional, Yoo, Alice, additional, Yousem, David M., additional, Yuen, Eric C., additional, Zabramski, Joseph M., additional, Zacest, Andrew C., additional, Zacko, J. Christopher, additional, Zada, Gabriel, additional, Zafonte, Ross, additional, Zager, Eric L., additional, Zaidi, Hasan A., additional, Zarzour, Hekmat, additional, Zerris, Vasilios A., additional, Zivin, Justin A., additional, Zovickian, John G., additional, Zubkov, Alexander Y., additional, and Zwienenberg-Lee, Marike, additional

Published
2011
Full Text
View/download PDF

31. Brain metastases

Author

Ewend, Matthew G., Carey, Lisa A., Morris, David E., Harvey, R. Donald, and Hensing, Thomas A.

Published
2001
Full Text
View/download PDF

50. A compact VEGF signature associated with distant metastases and poor outcomes

Author

Carey Lisa A, Ewend Matthew G, Oh Daniel S, He Xiaping, Livasy Chad, Fan Cheng, Hu Zhiyuan, Subramanian Subbaya, West Robert, Ikpatt Francis, Olopade Olufunmilayo I, van de Rijn Matt, and Perou Charles M

Subjects
Medicine
Abstract

Abstract Background Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies. Methods Microarrays and immunohistochemistry were used to analyze primary breast tumors, regional (lymph node) metastases, and distant metastases in order to identify biological features associated with distant metastases. Results When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct and distinguished by the lack of expression of fibroblast/mesenchymal genes, and by the high expression of a 13-gene profile (that is, the 'vascular endothelial growth factor (VEGF) profile') that included VEGF, ANGPTL4, ADM and the monocarboxylic acid transporter SLC16A3. At least 8 out of 13 of these genes contained HIF1α binding sites, many are known to be HIF1α-regulated, and expression of the VEGF profile correlated with HIF1α IHC positivity. The VEGF profile also showed prognostic significance on tests of sets of patients with breast and lung cancer and glioblastomas, and was an independent predictor of outcomes in primary breast cancers when tested in models that contained other prognostic gene expression profiles and clinical variables. Conclusion These data identify a compact in vivo hypoxia signature that tends to be present in distant metastasis samples, and which portends a poor outcome in multiple tumor types. This signature suggests that the response to hypoxia includes the ability to promote new blood and lymphatic vessel formation, and that the dual targeting of multiple cell types and pathways will be needed to prevent metastatic spread.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results