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Endometriosis continues to be an unsolved/unsolvable problem of modern gynecology. There are only 3 most common clinical phenotypes of this disorder: superficial peritoneal endometriosis, cystic ovarian endometriosis and deeply infiltrative endometriosis. In view of significantly reduced quality of life in patients with endometriosis resulting from algological symptoms and endometriosis-associated infertility, it is necessary to consider the features of clinical management of a patient with the “favorite” endometriosis localization to provide effective clinical management and improve the therapy efficacy.

Today, endometrial hyperplasia (EH) is among the most relevant gynecological entities. Arterial hypertension, diabetes mellitus and obesity, the combination of which is referred to as metabolic syndrome, are the key risk factors of EH. The incidence of EH and endometrial cancer grows proportionally based on the rapid increase in the prevalence of this set of symptoms among patients in the 21st century. Currently, there is a clear histological gradation of EH into atypical form and EH without atypia, which represents a key factor of the clinical management strategy (conser-vative or surgical) determination. However, high EH relapse rate after conservative treatment is the most important challenge of EH. In this re-gard, it is necessary to consider modern options for prevention of recurrent EH without atypia in patients of different ages.

Today, pelvic floor dysfunction (PFD) is one of the most pressing issues of modern gynecology. In patients with no macroscopic defects of the pelvic floor myofascial compartment, vaginal relaxation syndrome (VRS) that is highly prevalent among sexually active patients of child-bearing age represents the major PFD phenotype. Pregnancy and vaginal delivery constitute one of the most important etiological factors of VRS deter-mining high prevalence of the disorder. Furthermore, PFD results from the age-induced hypoestrogenism observed in peri- and postmenopausal patients. In such cases VRS and gaping vaginal opening may occur as early precursors of PFD. Based on the foregoing, it is important to consider the intimate contouring surgery as one of the most accessible and effective VRS correction methods for pelvic health restoration, improvement of the quality of life in general and sexual function in particular.

Pelvic floor dysfunction found in women regardless of their age has long been and remains one of the most controversial issues of modern gyne-cology. Numerous correction methods, from extensive surgical interventions to minimally invasive approaches, have been often opposed one an-other. However, to date we have formulated a clear recommendation: defects of the pelvic fascia and pelvic floor muscle compartment are the un-contested imperative indications for reconstructive surgery. Meanwhile, the issue of correcting early signs of pelvic floor dysfunction in patients with no myofascial defects is still a matter of debate, since surgical correction is often impossible or even more often not feasible in such cases. In this regard, it is necessary to consider perineal thread lifting as one of the most advanced and effective methods for treatment of the gaping vaginal opening that does not require surgical correction.

The drastic increase in life expectancy of the population, referred to as “silver tsunami” and demanding the development of such an entirely new branch of medical science as “anti-age medicine”, is one of the most pressing issues of modern demography. It is believed that aging of the body is inevitably associated with reduced quality of life, however, this postulate is currently urgently refuted, that is why the term “successful growing-up” is most relevant for the 21st century. There is a number of scientific studies focused on certain mechanisms underlying cellular senescence, which should be the therapeutic targets for prediction of age-related disorders. Thus, it is necessary to summarize the scientific evidence available and structure the modern approaches that contribute to “successful growing-up” under the innovation anti-aging concept.