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1. Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study

Author

Matthew Peak, Michael Griksaitis, Clare Fowler, Simon Gates, Christopher Lamb, Elizabeth Deja, Rachel Agbeko, John Pappachan, Helen Parker, Jennifer Preston, Ahmed Osman, Paula Williamson, Paul S McNamara, David Armstrong, Tracy Moitt, Ramesh Kumar, John Alexander, Kevin P Morris, Roger Parslow, Steve Cunningham, Craig Knott, Chloe Donohue, Catrin Barker, Julie Richardson, Ashley Jones, Stephanie Clarke, Malcolm G Semple, Richard Levin, James Weitz, Natasha Roberts, Vanessa Compton, Kentigern Thorburn, PHILIP MILNER, Howard W Clark, Bessie Cipriano, Nosheen Khalid, Nicolene Plaatjies, Avishay Sarfatti, Mark Terris, Santosh Sundararajan, Edgar Brincat, Natasha Thorn, Ramiya Kirupananthan, Peter J Davis, Samantha Owen, Pavanasam Ramesh, Sarah Fox, Laura Price, Hannah Clarke, Charlotte Thompson, Wendy Browne, Christine Mackerness, Laura Rad, Grace Williamson, Simone Paulson, Laura O'Malley, Zoe Oliver, Evette Allen, Clare van Miert, Ashley Best, Jens Madsen, Anne Dawson, Colin Summers, Blessing Osaghae, Madhuri Panchal, Anthony Postle, Peter Jirasek, Dawn Jones, Michael Mander, Laura Rimmer, Paul C Ritson, Chris Simons, Afeda Mohamed Ali, Cara Alexander, Hannah Child, Natalie Milburn, Holly Parkin, Harriet Payne, Carly Tooke, Helen Winmill, Katherine Baptiste, Sophie Coles, Sarah-Jayne Eames, Christina Linton, Helen Marley, Sarah Mogan, Alvin Schadenberg, John Stiven, Rob Claydon, Anna Stancombe, Kate Teeley, Kathryn Reeves, Emily Scriven, Raghu N Ramaiah, Rekha Patel, Patrick E Davies, Lindsay Crate, Kirsten Beadon, Rachel McMinnis, Frances Sinfield, Hilary Callaghan, Vicki Linton, Jeremy Lyons, Clara Nelson, Tsz-YanMilly Lo, Jackie McCormick, Andrea Wood, Ross Marscheider, Stephen D Playfor, Bernadette C Gavin, Dave J Morgan, Lara T Bunni, Claire F Jennings, Rebecca Marshall, Emma K Riley, Lorena Caruana, Amber Cook, Tracey Curtis, Nichola Etherington, Jenni McCorkell, Christie Mellish, Jenny Pond, Catherine Postlethwaite, Nicola McClelland, Holly Minchin, Joanne Tomlinson, Simona Lampariello, Tara Murray, Olivia Nugent, Samantha Reed, Christa Ronan, and Salman Siddiqi

Subjects
Medicine
Abstract

Objectives The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, including approach to consent within a limited time frame, we explored parent and staff experiences of trial involvement in the first two bronchiolitis seasons to inform subsequent trial conduct.Design A mixed-method embedded study involving a site staff survey, questionnaires and interviews with parents approached about BESS.Setting Fourteen UK paediatric intensive care units.Participants Of the 179 parents of children approached to take part in BESS, 75 parents (of 69 children) took part in the embedded study. Of these, 55/69 (78%) completed a questionnaire, and 15/69 (21%) were interviewed. Thirty-eight staff completed a questionnaire.Results Parents and staff found the trial acceptable. All constructs of the Adapted Theoretical Framework of Acceptability were met. Parents viewed surfactant as being low risk and hoped their child’s participation would help others in the future. Although parents supported research without prior consent in studies of time critical interventions, they believed there was sufficient time to consider this trial. Parents recommended that prospective informed consent should continue to be sought for BESS. Many felt that the time between the consent process and intervention being administered took too long and should be ‘streamlined’ to avoid delays in administration of trial interventions. Staff described how the training and trial processes worked well, yet patients were missed due to lack of staff to deliver the intervention, particularly at weekends.Conclusion Parents and staff supported BESS trial and highlighted aspects of the protocol, which should be refined, including a streamlined informed consent process. Findings will be useful to inform proportionate approaches to consent in future paediatric trials where there is a short timeframe for consent discussions.Trial registration number ISRCTN11746266.

Published
2024
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2. Development of an interdisciplinary microtia‐atresia care model: A single‐center 20‐year experience

Author

Krupa R. Patel, Liliya Benchetrit, Evette A. Ronner, Jessica Occhiogrosso, Tessa Hadlock, David Shaye, Alicia M. Quesnel, and Michael S. Cohen

Subjects
atresiaplasty, aural atresia, auricular reconstruction, bone conduction, Microtia, Otorhinolaryngology, RF1-547, Surgery, RD1-811
Abstract

Abstract Objectives Microtia and aural atresia are congenital ear anomalies with a wide‐ranging spectrum of phenotypes and varied functional and psychosocial consequences for patients. This study seeks to analyze the management of microtia‐atresia patients at our center over a 20‐year period and to propose recommendations for advancing microtia‐atresia care at a national level. Methods We performed a retrospective analysis of data from patients presenting to the Massachusetts Eye and Ear (Boston, MA) for initial otolaryngology consultation for congenital microtia and/or aural atresia between 1999 and 2018. Results Over the 20‐year study period, 229 patients presented to our microtia‐atresia center at a median age of 7 years. The severity of microtia was most commonly classified as grade III (n = 87, 38%), 61% (n = 140) of patients had complete atresia, the median Jahrsdoerfer grading scale score was 6 (range 0–10), and 81 patients (35%) underwent surgery for microtia repair. For hearing rehabilitation, 30 patients (64%) underwent bone conduction device implantation and 17 patients (36%) underwent atresiaplasty. The implementation of an interdisciplinary, longitudinal care model resulted in an increase in patient (r = 0.819, p

Published
2022
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3. Neighborhood-level characteristics as effect modifiers on the efficacy of the MyPEEPS mobile intervention in same-sex attracted adolescent men.

Author

Cordoba, Evette, Garofalo, Robert, Kuhns, Lisa, Pearson, Cynthia, Scott Batey, D, Janulis, Patrick, Jia, Haomiao, Bruce, Josh, Hidalgo, Marco, Hirshfield, Sabina, Radix, Asa, Belkind, Uri, Duncan, Dustin, Kim, Byoungjun, and Schnall, Rebecca

Subjects
Adolescent health, Community health, Gay/bisexual/transgender persons, Geospatial epidemiology, HIV prevention, HIV/AIDS, Mens health, Young sexual minority men
Abstract

To estimate the effect of neighborhood-level modification on the efficacy of the MyPEEPS Mobile intervention on the reduction of condomless anal sex acts among same-sex attracted adolescent men. A series of generalized linear mixed model was used to examine if the effect of the MyPEEPS Mobile intervention on condomless anal sex acts was moderated by neighborhood-level factors using data from the 2019 American Community Survey US Census Bureau. The magnitudes of intervention were significantly smaller at both 6- and 9-month follow-up among adolescents living in neighborhood with high proportions of Hispanic or Latino residents (IRR6M = 1.02, 95 % CI: 1.01, 1.02; IRR9M = 1.03, 95 % CI: 1.01, 1.05) and high proportions of families with income below the poverty level (IRR6M = 1.07, 95 % CI: 1.01, 1.12; IRR9M = 1.05, 95 % CI: 1.01, 1.10), which indicated that living in communities with a higher concentration of residents living under poverty or of Hispanic/and Latino ethnicity significantly modified the effective of program intervention on condomless sex among adolescent MSM. Understanding how neighborhood characteristics modify the effect of HIV prevention interventions may be useful in better targeting delivery and tailoring content of interventions based on neighborhood level characteristics such as the ones identified in this study.

Published
2024

10. Experimental study of riverbank protection with bio-engineering techniques

Author

Posi Sara, Montabonnet Lucas, Recking Alain, Evette André, Bellot Hervé, Ousset Frédéric, Ravanat Xavier, Piton Guillaume, and Solari Luca

Subjects
Environmental sciences, GE1-350
Abstract

River management implies in many situation to control the river bank stability. Bio-engineering techniques are used as an alternative to rip-rap. These techniques are not new but a renewed interest was observed during the last decade. However the design of such bank protection is still largely based an expert evaluation of each situation, and we still crudely lack a real state of the art, based on mechanistic consideration of forces exerted by the river. We present the results of preliminary flume experiments aiming to study the resistance of river bank protections using bio-engineering techniques. The final applied objectives will be to propose a framework for a good use of such technique, accounting for the river morphodynamics context.

Published
2018
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11. 2009 National Survey of First-Year Seminars

Author

Evette Allen

Subjects
first-year, seminar, programs, history, progression, extended orientation, uniform content, academics, pre-professional, discipline linked, basic study skills., Education (General), L7-991
Published
2015
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12. List of contributors

Author

Abdullah, Kalil, primary, Al-Asad, Reef K., additional, Batool, Syeda Maheen, additional, Brodsky, Jacob R., additional, Chae, Ricky, additional, Chari, Divya A., additional, Cochrane, Graham, additional, Cohen, Michael S., additional, Connors, Scott, additional, Crowson, Matthew Gordon, additional, Fallon, Keelin, additional, Garzon-Muvdi, Tomas, additional, Gramer, Robert M., additional, Herman, Seth, additional, Holmes, Sara, additional, Jiam, Nicole T., additional, Juliano, MD, Amy F., additional, Jung, David H., additional, Katz, Leanna W., additional, Kempfle, Judith S., additional, Knoll, Renata M., additional, Kozin, Elliott D., additional, Lee, Daniel J., additional, Littlefield, Philip D., additional, MacDonald, Kathryn C., additional, Patel, Krupa R., additional, Plitt, Aaron, additional, Reinshagen, Katherine L., additional, Remenschneider, Aaron K., additional, Ronner, Evette A., additional, Santos, MD, Felipe, additional, Shaye, David A., additional, Song, MD, Yohan, additional, Stapleton, Christopher J., additional, Vranic, Justin E., additional, and Wu, Matthew J., additional

Published
2024
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15. Considerations for reporting variants in novel candidate genes identified during clinical genomic testing

Author

Abouhala, Siwaar, Albert, Jessica, Almalvez, Miguel, Alvarez, Raquel, Amin, Mutaz, Anderson, Peter, Aradhya, Swaroop, Ashley, Euan, Assimes, Themistocles, Auriga, Light, Austin-Tse, Christina, Bamshad, Mike, Barseghyan, Hayk, Baxter, Samantha, Behera, Sairam, Beheshti, Shaghayegh, Bejerano, Gill, Berger, Seth, Bernstein, Jon, Best, Sabrina, Blankenmeister, Benjamin, Blue, Elizabeth, Boerwinkle, Eric, Bonkowski, Emily, Bonner, Devon, Boone, Philip, Bornhorst, Miriam, Brand, Harrison, Buckingham, Kati, Calame, Daniel, Carter, Jennefer, Casadei, Silvia, Chadwick, Lisa, Chavez, Clarisa, Chen, Ziwei, Chinn, Ivan, Chong, Jessica, Coban-Akdemir, Zeynep, Cohen, Andrea J., Conner, Sarah, Conomos, Matthew, Coveler, Karen, Cui, Ya Allen, Currin, Sara, Daber, Robert, Dardas, Zain, Davis, Colleen, Dawood, Moez, de Dios, Ivan, de Esch, Celine, Delaney, Meghan, Delot, Emmanuele, DiTroia, Stephanie, Doddapaneni, Harsha, Du, Haowei, Duan, Ruizhi, Dugan-Perez, Shannon, Duong, Nhat, Duyzend, Michael, Eichler, Evan, Emami, Sara, Fraser, Jamie, Fusaro, Vincent, Galey, Miranda, Ganesh, Vijay, Garcia, Brandon, Garimella, Kiran, Gibbs, Richard, Gifford, Casey, Ginsburg, Amy, Goddard, Page, Gogarten, Stephanie, Gogate, Nikhita, Gordon, William, Gorzynski, John E., Greenleaf, William, Grochowski, Christopher, Groopman, Emily, Sousa, Rodrigo Guarischi, Gudmundsson, Sanna, Gulati, Ashima, Hall, Stacey, Harvey, William, Hawley, Megan, Heavner, Ben, Horike-Pyne, Martha, Hu, Jianhong, Huang, Yongqing, Hwang, James, Jarvik, Gail, Jensen, Tanner, Jhangiani, Shalini, Jimenez-Morales, David, Jin, Christopher, Saad, Ahmed K., Kahn-Kirby, Amanda, Kain, Jessica, Kaur, Parneet, Keehan, Laura, Knoblach, Susan, Ko, Arthur, Kundaje, Anshul, Kundu, Soumya, Lancaster, Samuel M., Larsson, Katie, Lee, Arthur, Lemire, Gabrielle, Lewis, Richard, Li, Wei, Li, Yidan, Liu, Pengfei, LoTempio, Jonathan, Lupski, James (Jim), Ma, Jialan, MacArthur, Daniel, Mahmoud, Medhat, Malani, Nirav, Mangilog, Brian, Marafi, Dana, Marmolejos, Sofia, Marten, Daniel, Martinez, Eva, Marvin, Colby, Marwaha, Shruti, Mastrorosa, Francesco Kumara, Matalon, Dena, May, Susanne, McGee, Sean, Meador, Lauren, Mefford, Heather, Mendez, Hector Rodrigo, Miller, Alexander, Miller, Danny E., Mitani, Tadahiro, Montgomery, Stephen, Moyses, Mariana, Munderloh, Chloe, Muzny, Donna, Nelson, Sarah, Nguyen, Thuy-mi P., Nguyen, Jonathan, Nussbaum, Robert, Nykamp, Keith, O'Callaghan, William, O'Heir, Emily, O'Leary, Melanie, Olsen, Jeren, Osei-Owusu, Ikeoluwa, O'Donnell-Luria, Anne, Padhi, Evin, Pais, Lynn, Pan, Miao, Panchal, Piyush, Patterson, Karynne, Payne, Sheryl, Pehlivan, Davut, Petrowski, Paul, Pham, Alicia, Pitsava, Georgia, Podesta, Astaria`Sara, Ponce, Sarah, Porter, Elizabeth, Posey, Jennifer, Prosser, Jaime, Quertermous, Thomas, Rai, Archana, Ramani, Arun, Rehm, Heidi, Reuter, Chloe, Reuter, Jason, Richardson, Matthew, Rivera-Munoz, Andres, Rubio, Oriane, Sabo, Aniko, Salani, Monica, Samocha, Kaitlin, Sanchis-Juan, Alba, Savage, Sarah, Scott, Evette, Scott, Stuart, Sedlazeck, Fritz, Shah, Gulalai, Shojaie, Ali, Singh, Mugdha, Smith, Kevin, Smith, Josh, Snow, Hana, Snyder, Michael, Socarras, Kayla, Starita, Lea, Stark, Brigitte, Stenton, Sarah, Stergachis, Andrew, Stilp, Adrienne, Sutton, V. Reid, Tai, Jui-Cheng, Talkowski, Michael (Mike), Tise, Christina, Tong, Catherine (Cat), Tsao, Philip, Ungar, Rachel, VanNoy, Grace, Vilain, Eric, Voutos, Isabella, Walker, Kim, Wei, Chia-Lin, Weisburd, Ben, Weiss, Jeff, Wellington, Chris, Weng, Ziming, Westheimer, Emily, Wheeler, Marsha, Wheeler, Matthew, Wiel, Laurens, Wilson, Michael, Wojcik, Monica, Wong, Quenna, Xiao, Changrui, Yadav, Rachita, Yi, Qian, Yuan, Bo, Zhao, Jianhua, Zhen, Jimmy, Zhou, Harry, Chong, Jessica X., Berger, Seth I., Smith, Erica, Calame, Daniel G., Hawley, Megan H., Rivera-Munoz, E. Andres, Bamshad, Michael J., and Rehm, Heidi L.

Published
2024
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17. Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma.

Author

Duch, Paula, Díaz-Valdivia, Natalia, Ikemori, Rafael, Gabasa, Marta, Radisky, Evette, Arshakyan, Marselina, Gea-Sorlí, Sabrina, Mateu-Bosch, Anna, Bragado, Paloma, Carrasco, Josep, Mori, Hidetoshi, Ramírez, Josep, Teixidó, Cristina, Reguart, Noemí, Fillat, Cristina, Radisky, Derek, and Alcaraz, Jordi

Subjects
CD63, Cancer-associated fibroblast, Fibrosis, SMAD3, TGF-β1, TIMP-1, Tumor microenvironment, Adenocarcinoma of Lung, Animals, Cancer-Associated Fibroblasts, Carcinoma, Squamous Cell, Fibroblasts, Humans, Lung Neoplasms, Mice, Tetraspanin 30, Tissue Inhibitor of Metalloproteinase-1, Transforming Growth Factor beta1, Tumor Microenvironment
Abstract

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metalloproteinases. Intriguingly, this interpretation has been challenged by the consistent observation that increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types including lung cancer, supporting a tumor-promoting function. However, how TIMP-1 is dysregulated within the tumor microenvironment and how it drives tumor progression in lung cancer is poorly understood. We analyzed the expression of TIMP-1 and its cell surface receptor CD63 in two major lung cancer subtypes: lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC), and defined the tumor-promoting effects of their interaction. We found that TIMP-1 is aberrantly overexpressed in tumor-associated fibroblasts (TAFs) in ADC compared to SCC. Mechanistically, TIMP-1 overexpression was mediated by the selective hyperactivity of the pro-fibrotic TGF-β1/SMAD3 pathway in ADC-TAFs. Likewise, CD63 was upregulated in ADC compared to SCC cells. Genetic analyses revealed that TIMP-1 secreted by TGF-β1-activated ADC-TAFs is both necessary and sufficient to enhance growth and invasion of ADC cancer cells in culture, and that tumor cell expression of CD63 was required for these effects. Consistently, in vivo analyses revealed that ADC cells co-injected with fibroblasts with reduced SMAD3 or TIMP-1 expression into immunocompromised mice attenuated tumor aggressiveness compared to tumors bearing parental fibroblasts. We also found that high TIMP1 and CD63 mRNA levels combined define a stronger prognostic biomarker than TIMP1 alone. Our results identify an excessive stromal TIMP-1 within the tumor microenvironment selectively in lung ADC, and implicate it in a novel tumor-promoting TAF-carcinoma crosstalk, thereby pointing to TIMP-1/CD63 interaction as a novel therapeutic target in lung cancer.

Published
2022

18. Fostering Reading: Supporting Foster Children through Virtual Tutoring

Author

Harrell, Evette and Wasburn-Moses, Leah

Abstract

Professional literature presents evidence that foster care agencies, foster parents, and educators are unprepared to meet the distinctive educational needs of foster youth. Although there is a general lack of evidence on specific interventions developed for foster youth, some studies have addressed the impact of tutoring. This paper studies the impact of a pilot program that paired 15 teacher candidates with 15 foster youth for virtual reading tutoring as part of a college course. Data were collected from youth, parents, and teacher candidates through surveys and focus groups. The results of this study suggested that the tutoring relationship produced several academic and emotional benefits for both foster youth and tutors. Participants all saw evidence of increases in the tutees' skill level and content knowledge, and tutors overwhelmingly reported feelings of fulfillment. The establishment of a strong, supportive relationship between tutor and tutee was also seen as a primary factor in success. Finally, the study presented evidence that diverse instructional resources and methods are important for youth engagement and that tutors need in-depth, thorough training on how to locate and properly use these types of resources. Suggestions for future research are proposed.

Published
2023

19. A Study of Emotional Intelligence on Job Satisfaction among Student Support Staff at Historically Black Colleges/Universities

Author

Evette Lloyd Bridges

Abstract

The problem was that Historically Black Colleges/Universities (HBCU) stakeholders must observe ways that student support professionals increases organizational effectiveness, for there is a need to understand the correlation of emotional intelligence (EI) and job satisfaction. The purpose of this quantitative, causal-comparative study was to investigate views useful to EI and job satisfaction among student support personnel at four public HBCUs. Data collection involved completing online surveys. A total of 83 participants responded to the survey request. Among the 83 participants, 66% (n = 55) had responded to all the survey items. A Pearson product-moment correlation was used to first determine if there was any relationship between the EI predictors and the job satisfaction outcome variables simultaneously. Results indicated there was no significant correlation between Overall Emotional Intelligence rating and Overall Job Satisfaction rating. The Pearson coefficient of 0.111 indicated that there was a very weak positive correlation between EI and job satisfaction. The data of this study gave an understanding of the correlation among student support personnel's EI and job satisfaction and revealed that if such constructs impacted employee's work performance, they, consequently, increased student retention. Further, this study was used to expand research literature and provide leadership with a vision to develop an effective method for improved employee satisfaction and customer service. This study can guide other HBCU colleges and universities, predominately White institutions (PWIs), and any other workforce industries. Future research would benefit from investigating the relationship between EI and job satisfaction among student support staff at HBCUs more systematically by expanding to other higher education departments, other public and private HBCUs and PWIs, and 2-year community colleges in other states, domestically and internationally, with an increased sample size. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2023

25. Preventing severe hypoglycemia in adults with type 2 diabetes (PHT2): Design, delivery and evaluation framework for a randomized controlled trial

Author

Ralston, James D., Anderson, Melissa, Ng, Janet, Bashir, Ayat, Ehrlich, Kelly, Burns-Hunt, Dena, Cotton, Meredith, Hansell, Laurel, Hsu, Clarissa, Hunt, Helen, Karter, Andrew J., Levy, Shaula M., Ludman, Evette, Madziwa, Lawrence, Omura, Emily M., Rogers, Kristine, Sevey, Brandie, Shaw, James A.M., Shortreed, Susan M., Singh, Umesh, Speight, Jane, Sweeny, Amber, Tschernisch, Katherine, Sergei Tschernisch, S., and Yarborough, Laura

Published
2024
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27. Developing Mentor Teachers to Support Student Teacher Candidates

Author

McGee, Inger Evette

Abstract

This article shares development of a mentor teacher training program to support teacher candidates in their student teaching internship. The mentor teacher training program includes three parts: (a) online training on internship processes and procedures, co-teaching, and a department developed Framework for Extended Oral and Written Feedback, (b) face-to-face orientation session to clarify co-teaching and feedback framework, and (c) co-observation of intern candidates by faculty supervisor and mentor teacher. The goal of the mentor teacher training program is to orient mentor teachers to the internship and to train them in providing high quality, actionable feedback that leads the teacher candidate to improved practice.

Published
2019

29. Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement

Author

Coban, Mathew, PhD, Juliet Morrison, MD, William D. Freeman, PhD, Evette Radisky, PhD, Karine G. Le Roch, and PhD, Thomas R. Caulfield

Subjects
Quantitative Biology - Biomolecules, Quantitative Biology - Cell Behavior
Abstract

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 11.6 million (25% located in United States) and killed more than 540K people around the world. As we face one of the most challenging times in our recent history, there is an urgent need to identify drug candidates that can attack SARS-CoV-2 on multiple fronts. We have therefore initiated a computational dynamics drug pipeline using molecular modeling, structure simulation, docking and machine learning models to predict the inhibitory activity of several million compounds against two essential SARS-CoV-2 viral proteins and their host protein interactors; S/Ace2, Tmprss2, Cathepsins L and K, and Mpro to prevent binding, membrane fusion and replication of the virus, respectively. All together we generated an ensemble of structural conformations that increase high quality docking outcomes to screen over >6 million compounds including all FDA-approved drugs, drugs under clinical trial (>3000) and an additional >30 million selected chemotypes from fragment libraries. Our results yielded an initial set of 350 high value compounds from both new and FDA-approved compounds that can now be tested experimentally in appropriate biological model systems. We anticipate that our results will initiate screening campaigns and accelerate the discovery of COVID-19 treatments., Comment: Main text: 29 pages with references, 1 main table, 6 main figures; Supplemental section: 30 pages, 3 supplemental tables, 4 supplemental figures

Published
2020
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30. Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement.

Author

Coban, Mathew A, Morrison, Juliet, Maharjan, Sushila, Hernandez Medina, David Hyram, Li, Wanlu, Zhang, Yu Shrike, Freeman, William D, Radisky, Evette S, Le Roch, Karine G, Weisend, Carla M, Ebihara, Hideki, and Caulfield, Thomas R

Subjects
Humans, Serine Endopeptidases, Viral Envelope Proteins, Antiviral Agents, Virus Replication, Binding Sites, Drug Discovery, Drug Repositioning, Molecular Docking Simulation, Machine Learning, COVID-19, Angiotensin-Converting Enzyme 2, SARS-CoV-2, COVID, bioprinting, drug discovery, multi-drug therapy, Biochemistry and Cell Biology
Abstract

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 160 million (>20% located in United States) and killed more than 3.3 million people around the world (>20% deaths in USA). As we face one of the most challenging times in our recent history, there is an urgent need to identify drug candidates that can attack SARS-CoV-2 on multiple fronts. We have therefore initiated a computational dynamics drug pipeline using molecular modeling, structure simulation, docking and machine learning models to predict the inhibitory activity of several million compounds against two essential SARS-CoV-2 viral proteins and their host protein interactors-S/Ace2, Tmprss2, Cathepsins L and K, and Mpro-to prevent binding, membrane fusion and replication of the virus, respectively. All together, we generated an ensemble of structural conformations that increase high-quality docking outcomes to screen over >6 million compounds including all FDA-approved drugs, drugs under clinical trial (>3000) and an additional >30 million selected chemotypes from fragment libraries. Our results yielded an initial set of 350 high-value compounds from both new and FDA-approved compounds that can now be tested experimentally in appropriate biological model systems. We anticipate that our results will initiate screening campaigns and accelerate the discovery of COVID-19 treatments.

Published
2021

32. Gene content evolution in the arthropods

Author

Thomas, Gregg WC, Dohmen, Elias, Hughes, Daniel ST, Murali, Shwetha C, Poelchau, Monica, Glastad, Karl, Anstead, Clare A, Ayoub, Nadia A, Batterham, Phillip, Bellair, Michelle, Binford, Greta J, Chao, Hsu, Chen, Yolanda H, Childers, Christopher, Dinh, Huyen, Doddapaneni, Harsha Vardhan, Duan, Jian J, Dugan, Shannon, Esposito, Lauren A, Friedrich, Markus, Garb, Jessica, Gasser, Robin B, Goodisman, Michael AD, Gundersen-Rindal, Dawn E, Han, Yi, Handler, Alfred M, Hatakeyama, Masatsugu, Hering, Lars, Hunter, Wayne B, Ioannidis, Panagiotis, Jayaseelan, Joy C, Kalra, Divya, Khila, Abderrahman, Korhonen, Pasi K, Lee, Carol Eunmi, Lee, Sandra L, Li, Yiyuan, Lindsey, Amelia RI, Mayer, Georg, McGregor, Alistair P, McKenna, Duane D, Misof, Bernhard, Munidasa, Mala, Munoz-Torres, Monica, Muzny, Donna M, Niehuis, Oliver, Osuji-Lacy, Nkechinyere, Palli, Subba R, Panfilio, Kristen A, Pechmann, Matthias, Perry, Trent, Peters, Ralph S, Poynton, Helen C, Prpic, Nikola-Michael, Qu, Jiaxin, Rotenberg, Dorith, Schal, Coby, Schoville, Sean D, Scully, Erin D, Skinner, Evette, Sloan, Daniel B, Stouthamer, Richard, Strand, Michael R, Szucsich, Nikolaus U, Wijeratne, Asela, Young, Neil D, Zattara, Eduardo E, Benoit, Joshua B, Zdobnov, Evgeny M, Pfrender, Michael E, Hackett, Kevin J, Werren, John H, Worley, Kim C, Gibbs, Richard A, Chipman, Ariel D, Waterhouse, Robert M, Bornberg-Bauer, Erich, Hahn, Matthew W, and Richards, Stephen

Subjects
Human Genome, Genetics, Biotechnology, Generic health relevance, Animals, Arthropods, DNA Methylation, Evolution, Molecular, Genetic Speciation, Genetic Variation, Phylogeny, Genome assembly, Genomics, Protein domains, Gene content, Evolution, DNA methylation, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundArthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods.ResultsUsing 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception.ConclusionsThese analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity.

Published
2020

33. Beyond the exome: What’s next in diagnostic testing for Mendelian conditions

Author

Abouhala, Siwaar, Albert, Jessica, Almalvez, Miguel, Alvarez, Raquel, Amin, Mutaz, Anderson, Peter, Aradhya, Swaroop, Ashley, Euan, Assimes, Themistocles, Auriga, Light, Austin-Tse, Christina, Bamshad, Mike, Barseghyan, Hayk, Baxter, Samantha, Behera, Sairam, Beheshti, Shaghayegh, Bejerano, Gill, Berger, Seth, Bernstein, Jon, Best, Sabrina, Blankenmeister, Benjamin, Blue, Elizabeth, Boerwinkle, Eric, Bonkowski, Emily, Bonner, Devon, Boone, Philip, Bornhorst, Miriam, Bozkurt-Yozgatli, Tugce, Brand, Harrison, Buckingham, Kati, Calame, Daniel, Casadei, Silvia, Chadwick, Lisa, Chavez, Clarisa, Chen, Ziwei, Chinn, Ivan, Chong, Jessica, Coban-Akdemir, Zeynep, Cohen, Andrea J., Conner, Sarah, Conomos, Matthew, Coveler, Karen, Cui, Ya Allen, Currin, Sara, Daber, Robert, Dardas, Zain, Davis, Colleen, Dawood, Moez, de Dios, Ivan, de Esch, Celine, Delaney, Meghan, Délot, Emmanuèle, DiTroia, Stephanie, Doddapaneni, Harsha, Du, Haowei, Duan, Ruizhi, Dugan-Perez, Shannon, Duong, Nhat, Duyzend, Michael, Eichler, Evan, Emami, Sara, Fatih, Jawid, Fraser, Jamie, Fusaro, Vincent, Galey, Miranda, Ganesh, Vijay, Garimella, Kiran, Gibbs, Richard, Gifford, Casey, Ginsburg, Amy, Goddard, Pagé, Gogarten, Stephanie, Gogate, Nikhita, Gordon, William, Gorzynski, John E., Greenleaf, William, Grochowski, Christopher, Groopman, Emily, Guarischi Sousa, Rodrigo, Gudmundsson, Sanna, Gulati, Ashima, Guo, Daniel, Hale, Walker, Hall, Stacey, Harvey, William, Hawley, Megan, Heavner, Ben, Herman, Isabella, Horike-Pyne, Martha, Hu, Jianhong, Huang, Yongqing, Hwang, James, Jarvik, Gail, Jensen, Tanner, Jhangiani, Shalini, Jimenez-Morales, David, Jin, Christopher, Saad, Ahmed K., Kahn-Kirby, Amanda, Kain, Jessica, Kaur, Parneet, Keehan, Laura, Knoblach, Susan, Ko, Arthur, Kohler, Jennefer, Kundaje, Anshul, Kundu, Soumya, Lancaster, Samuel M., Larsson, Katie, Lemire, Gabrielle, Lewis, Richard, Li, Wei, Li, Yidan, Liu, Pengfei, LoTempio, Jonathan, Lupski, James, Ma, Jialan, MacArthur, Daniel, Mahmoud, Medhat, Malani, Nirav, Mangilog, Brian, Marafi, Dana, Marmolejos, Sofia, Marten, Daniel, Martinez, Eva, Marvin, Colby, Marwaha, Shruti, Kumara Mastrorosa, Francesco, Matalon, Dena, May, Susanne, McGee, Sean, Meador, Lauren, Mefford, Heather, Rodrigo Mendez, Hector, Miller, Alexander, Miller, Danny E., Mitani, Tadahiro, Montgomery, Stephen, Moussa, Hala Mohamed, Moyses, Mariana, Munderloh, Chloe, Muzny, Donna, Nelson, Sarah, Neu, Matthew B., Nguyen, Jonathan, Nguyen, Thuy-mi P., Nussbaum, Robert, Nykamp, Keith, O'Callaghan, William, O'Heir, Emily, O'Leary, Melanie, Olsen, Jeren, Osei-Owusu, Ikeoluwa, O'Donnell-Luria, Anne, Padhi, Evin, Pais, Lynn, Pan, Miao, Panchal, Piyush, Patterson, Karynne, Payne, Sheryl, Pehlivan, Davut, Petrowski, Paul, Pham, Alicia, Pitsava, Georgia, Podesta, Astaria, Ponce, Sarah, Posey, Jennifer, Prosser, Jaime, Quertermous, Thomas, Rai, Archana, Ramani, Arun, Rehm, Heidi, Reuter, Chloe, Reuter, Jason, Richardson, Matthew, Rivera-Munoz, Andres, Rubio, Oriane, Sabo, Aniko, Salani, Monica, Samocha, Kaitlin, Sanchis-Juan, Alba, Savage, Sarah, Scott, Stuart, Scott, Evette, Sedlazeck, Fritz, Shah, Gulalai, Shojaie, Ali, Singh, Mugdha, Smith, Josh, Smith, Kevin, Snow, Hana, Snyder, Michael, Socarras, Kayla, Starita, Lea, Stark, Brigitte, Stenton, Sarah, Stergachis, Andrew, Stilp, Adrienne, Sundaram, Laksshman, Sutton, V. Reid, Tai, Jui-Cheng, Talkowski, Michael, Tise, Christina, Tong, Catherine, Tsao, Philip, Ungar, Rachel, VanNoy, Grace, Vilain, Eric, Voutos, Isabella, Walker, Kim, Weisburd, Ben, Weiss, Jeff, Wellington, Chris, Weng, Ziming, Westheimer, Emily, Wheeler, Marsha, Wheeler, Matthew, Wiel, Laurens, Wilson, Michael, Wojcik, Monica, Wong, Quenna, Wong, Issac, Xiao, Changrui, Yadav, Rachita, Yi, Qian, Yuan, Bo, Zhao, Jianhua, Zhen, Jimmy, Zhou, Harry, Wojcik, Monica H., Reuter, Chloe M., Duyzend, Michael H., Boone, Philip M., Groopman, Emily E., Délot, Emmanuèle C., Jain, Deepti, Starita, Lea M., Montgomery, Stephen B., Bamshad, Michael J., Chong, Jessica X., Wheeler, Matthew T., Berger, Seth I., and Sedlazeck, Fritz J.

Published
2023
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35. Considering College Alternatives

Author

Trammell, Beth A., Kazee, Amanda, Wilczynski, Susan M., Simmons-Reed, Evette, Kraft, Anita, Sundberg, Shawnna, Viezel, Kathleen D., editor, Wilczynski, Susan M., editor, and Davis, Andrew S., editor

Published
2022
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36. SSIS Performance Screening Guide as an Indicator of Behavior and Academics: A Meta-Analysis

Author

Sullivan, Jeremy R., Villarreal, Victor, Flores, Evette, Gomez, Alyssa, and Warren, Blaire

Abstract

This article documents the results of a meta-analysis of available correlational validity evidence for the Social Skills Improvement System Performance Screening Guide (SSIS-PSG), which is a brief teacher-completed rating scale designed to be used as part of universal screening procedures. Article inclusion criteria included (a) published in English in a peer-reviewed journal, (b) administration of the PSG, and (c) provided validity evidence representative of the relationship between PSG scores and scores on related variables. Ten studies yielding 147 correlation coefficients met criteria for inclusion. Data were extracted following established procedures in validity generalization and meta-analytic research. Extracted coefficients were of the expected direction and magnitude with theoretically aligned constructs, thereby providing evidence of convergent validity (e.g., PSG Math and Reading items were most strongly correlated with academic performance and academic behavior variables, with effect sizes ranging from 0.708 to 0.740; PSG Prosocial Behavior and Motivation to Learn items were most strongly correlated with broadband externalizing/internalizing problems, with effect sizes ranging from -0.706 to -0.717), although Prosocial Behavior and Motivation to Learn were not as effective at discriminating among divergent constructs. These results generally support the utility of the PSG in correlating with academic and social/behavioral outcomes in the schools.

Published
2021
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38. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Author

Raeeszadeh-Sarmazdeh, Maryam, Greene, Kerrie A, Sankaran, Banumathi, Downey, Gregory P, Radisky, Derek C, and Radisky, Evette S

Subjects
Biochemistry and Cell Biology, Biological Sciences, 2.1 Biological and endogenous factors, Aetiology, Amino Acid Sequence, Binding Sites, Catalytic Domain, Crystallography, X-Ray, Directed Molecular Evolution, Humans, Matrix Metalloproteinase 3, Matrix Metalloproteinase Inhibitors, Mutation, Protein Binding, Protein Conformation, Protein Domains, Tissue Inhibitor of Metalloproteinase-1, Two-Hybrid System Techniques, crystal structure, directed evolution, matrix metalloproteinase, metalloprotease, protease inhibitor, protein domain, protein engineering, protein structure, protein-protein interaction, tissue inhibitor of metalloproteinase, yeast surface display, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and degenerative diseases. The TIMP N-terminal domain binds and inhibits an MMP catalytic domain, but the role of the TIMP C-terminal domain in MMP inhibition is poorly understood. Here, we employed yeast surface display for directed evolution of full-length human TIMP-1 to develop MMP-3-targeting ultrabinders. By simultaneously incorporating diversity into both domains, we identified TIMP-1 variants that were up to 10-fold improved in binding MMP-3 compared with WT TIMP-1, with inhibition constants (Ki ) in the low picomolar range. Analysis of individual and paired mutations from the selected TIMP-1 variants revealed cooperative effects between distant residues located on the N- and C-terminal TIMP domains, positioned on opposite sides of the interaction interface with MMP-3. Crystal structures of MMP-3 complexes with TIMP-1 variants revealed conformational changes in TIMP-1 near the cooperative mutation sites. Affinity was strengthened by cinching of a reciprocal "tyrosine clasp" formed between the N-terminal domain of TIMP-1 and proximal MMP-3 interface and by changes in secondary structure within the TIMP-1 C-terminal domain that stabilize interdomain interactions and improve complementarity to MMP-3. Our protein engineering and structural studies provide critical insight into the cooperative function of TIMP domains and the significance of peripheral TIMP epitopes in MMP recognition. Our findings suggest new strategies to engineer TIMP proteins for therapeutic applications, and our directed evolution approach may also enable exploration of functional domain interactions in other protein systems.

Published
2019

39. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Author

Cohen, Itay, Coban, Matt, Shahar, Anat, Sankaran, Banumathi, Hockla, Alexandra, Lacham, Shiran, Caulfield, Thomas R, Radisky, Evette S, and Papo, Niv

Subjects
Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Biotechnology, Development of treatments and therapeutic interventions, Aetiology, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Generic health relevance, Amyloid beta-Protein Precursor, Animals, Aprotinin, Crystallography, X-Ray, Disulfides, Humans, Models, Molecular, Protein Conformation, Protein Domains, Protein Engineering, Proteolysis, Trypsin, crystal structure, disulfide, molecular dynamics, protease inhibitor, protein engineering, protein structure, proteolysis, serine protease, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Serine protease inhibitors of the Kunitz-bovine pancreatic trypsin inhibitor (BPTI) family are ubiquitous biological regulators of proteolysis. These small proteins are resistant to proteolysis, but can be slowly cleaved within the protease-binding loop by target proteases, thereby compromising their activity. For the human protease mesotrypsin, this cleavage is especially rapid. Here, we aimed to stabilize the Kunitz domain structure against proteolysis through disulfide engineering. Substitution within the Kunitz inhibitor domain of the amyloid precursor protein (APPI) that incorporated a new disulfide bond between residues 17 and 34 reduced proteolysis by mesotrypsin 74-fold. Similar disulfide engineering of tissue factor pathway inhibitor-1 Kunitz domain 1 (KD1TFPI1) and bikunin Kunitz domain 2 (KD2bikunin) likewise stabilized these inhibitors against mesotrypsin proteolysis 17- and 6.6-fold, respectively. Crystal structures of disulfide-engineered APPI and KD1TFPI1 variants in a complex with mesotrypsin at 1.5 and 2.0 Å resolution, respectively, confirmed the formation of well-ordered disulfide bonds positioned to stabilize the binding loop. Long all-atom molecular dynamics simulations of disulfide-engineered Kunitz domains and their complexes with mesotrypsin revealed conformational stabilization of the primed side of the inhibitor-binding loop by the engineered disulfide, along with global suppression of conformational dynamics in the Kunitz domain. Our findings suggest that the Cys-17-Cys-34 disulfide slows proteolysis by dampening conformational fluctuations in the binding loop and minimizing motion at the enzyme-inhibitor interface. The generalizable approach developed here for the stabilization against proteolysis of Kunitz domains, which can serve as important scaffolds for therapeutics, may thus find applications in drug development.

Published
2019

40. Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol.

Author

Yaffe, Kristine, Barnes, Deborah E, Rosenberg, Dori, Dublin, Sascha, Kaup, Allison R, Ludman, Evette J, Vittinghoff, Eric, Peltz, Carrie B, Renz, Anne D, Adams, Kristin J, and Larson, Eric B

Subjects
Humans, Alzheimer Disease, Single-Blind Method, Risk Reduction Behavior, Aged, Aged, 80 and over, Health Promotion, Female, Male, Randomized Controlled Trials as Topic, Alzheimer’s disease, dementia, health promotion, integrated delivery of health care, risk reduction behavior, Alzheimer's disease, Neurology & Neurosurgery, Clinical Sciences, Neurosciences, Cognitive Sciences
Abstract

This article describes the protocol for the Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT), a single-blind randomized pilot trial to test a personalized, pragmatic, multi-domain Alzheimer's disease (AD) risk reduction intervention in a US integrated healthcare delivery system. Study participants will be 200 higher-risk older adults (age 70-89 years with subjective cognitive complaints, low normal performance on cognitive screen, and ≥ two modifiable risk factors targeted by our intervention) who will be recruited from selected primary care clinics of Kaiser Permanente Washington, oversampling people with non-white race or Hispanic ethnicity. Study participants will be randomly assigned to a two-year Alzheimer's risk reduction intervention (SMARRT) or a Health Education (HE) control. Randomization will be stratified by clinic, race/ethnicity (non-Hispanic white versus non-white or Hispanic), and age (70-79, 80-89). Participants randomized to the SMARRT group will work with a behavioral coach and nurse to develop a personalized plan related to their risk factors (poorly controlled hypertension, diabetes with evidence of hyper or hypoglycemia, depressive symptoms, poor sleep quality, contraindicated medications, physical inactivity, low cognitive stimulation, social isolation, poor diet, smoking). Participants in the HE control group will be mailed general health education information about these risk factors for AD. The primary outcome is two-year cognitive change on a cognitive test composite score. Secondary outcomes include: 1) improvement in targeted risk factors, 2) individual cognitive domain composite scores, 3) physical performance, 4) functional ability, 5) quality of life, and 6) incidence of mild cognitive impairment, AD, and dementia. Primary and secondary outcomes will be assessed in both groups at baseline and 6, 12, 18, and 24 months.

Published
2019

41. Mitigation of SARS-CoV-2 transmission at a large public university

Author

Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Richard L. Fredrickson, Tong Wang, George N. Wong, Johnny Uelmen, Sergei Maslov, Zachary J. Weiner, Alexei V. Tkachenko, Hantao Zhang, Zhiru Liu, Ahmed Ibrahim, Sanjay J. Patel, John M. Paul, Nickolas P. Vance, Joseph G. Gulick, Sandeep Puthanveetil Satheesan, Isaac J. Galvan, Andrew Miller, Joseph Grohens, Todd J. Nelson, Mary P. Stevens, P Mark Hennessy, Robert C. Parker, Edward Santos, Charles Brackett, Julie D. Steinman, Melvin R. Fenner, Kirstin Dohrer, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R. Brauer, Catherine Best-Popescu, Gary Durack, Nathan Wetter, David M. Kranz, Jessica Breitbarth, Charlie Simpson, Julie A. Pryde, Robin N. Kaler, Chris Harris, Allison C. Vance, Jodi L. Silotto, Mark Johnson, Enrique Andres Valera, Patricia K. Anton, Lowa Mwilambwe, Stephen P. Bryan, Deborah S. Stone, Danita B. Young, Wanda E. Ward, John Lantz, John A. Vozenilek, Rashid Bashir, Jeffrey S. Moore, Mayank Garg, Julian C. Cooper, Gillian Snyder, Michelle H. Lore, Dustin L. Yocum, Neal J. Cohen, Jan E. Novakofski, Melanie J. Loots, Randy L. Ballard, Mark Band, Kayla M. Banks, Joseph D. Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Abigail Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W. Fouke, Nicholas Gallagher, Nicole Gastala, Scott A. Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M. Healy, Ashley Hetrick, Arianna A. Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M. Kindle, Rhonda L. Lipking, Yukari C. Manabe, Jade ́ Mayes, Reubin McGuffin, Kenton G. McHenry, Agha Mirza, Jada Moseley, Heba H. Mostafa, Melody Mumford, Kathleen Munoz, Arika D. Murray, Moira Nolan, Nil A. Parikh, Andrew Pekosz, Janna Pflugmacher, Janise M. Phillips, Collin Pitts, Mark C. Potter, James Quisenberry, Janelle Rear, Matthew L. Robinson, Edith Rosillo, Leslie N. Rye, MaryEllen Sherwood, Anna Simon, Jamie M. Singson, Carly Skadden, Tina H. Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A. Tomaszewski, Erika A. Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S. Watkins, Karriem Watson, Karen C. White, Timothy L. Killeen, Robert J. Jones, Andreas C. Cangellaris, Susan A. Martinis, Awais Vaid, Christopher B. Brooke, Joseph T. Walsh, Ahmed Elbanna, William C. Sullivan, Rebecca L. Smith, Nigel Goldenfeld, Timothy M. Fan, Paul J. Hergenrother, and Martin D. Burke

Subjects
Science
Abstract

Safely opening university campuses has been a major challenge during the COVID-19 pandemic. Here, the authors describe a program of public health measures employed at a university in the United States which, combined with other non-pharmaceutical interventions, allowed the university to stay open in fall 2020 with limited evidence of transmission.

Published
2022
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44. Mirrors to the Soul: Elementary Preservice Teachers' Critical Reflections of Situating Race, Racism, and Antiracism within the Literacy Curriculum

Author

Cunningham, Marian Evette

Abstract

Research that engages preservice teachers in critical reflective practices may reveal the level at which they understand and confront their own biases when addressing race within the institutions and societies they interact. This study was conducted to understand the depth in which elementary preservice teachers critically reflect on their own racialized experiences and beliefs and how they situate race within the literacy curriculum through the lens of critical race theory. Semi-structured interviews were conducted with 21 preservice teachers. Findings indicated that preservice teachers believe antiracist themes should be integrated into literacy. However, due to lack of exposure, limited coursework, and curriculum mandates, they were not fully prepared to address race, racism, and antiracism within literacy instruction. Future research should focus on revising teacher education programs to include a more concrete focus on race and racism, specifically ways to navigate those topics within elementary literacy classrooms. Additionally, future research that examines how to better support and understand the mentor teacher's role in supporting culturally relevant and antiracist pedagogies is recommended. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2021

47. Toward an Understanding of Intersectionality Methodology: A 30-Year Literature Synthesis of Black Women's Experiences in Higher Education

Author

Haynes, Chayla, Joseph, Nicole M., Patton, Lori D., Stewart, Saran, and Allen, Evette L.

Abstract

Kimberlé Crenshaw's scholarship on Black women has been the springboard for numerous education studies in which researchers use intersectionality as a theoretical framework; however, few have considered the possibilities of intersectionality as a methodological tool. In this literature synthesis, the authors (a) examined studies about Black women in higher education that had been published in the past 30 years to understand how those scholars applied intersectionality across Crenshaw's three dimensions (i.e., structural, political, and representational) and (b) advanced a set of four strategies, arguably providing a guide for engaging "intersectionality methodology," what the authors coin as "IM." Implications for higher education research and social science research broadly are also presented.

Published
2020
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48. Mitigation of SARS-CoV-2 transmission at a large public university

Author

Ranoa, Diana Rose E., Holland, Robin L., Alnaji, Fadi G., Green, Kelsie J., Wang, Leyi, Fredrickson, Richard L., Wang, Tong, Wong, George N., Uelmen, Johnny, Maslov, Sergei, Weiner, Zachary J., Tkachenko, Alexei V., Zhang, Hantao, Liu, Zhiru, Ibrahim, Ahmed, Patel, Sanjay J., Paul, John M., Vance, Nickolas P., Gulick, Joseph G., Satheesan, Sandeep Puthanveetil, Galvan, Isaac J., Miller, Andrew, Grohens, Joseph, Nelson, Todd J., Stevens, Mary P., Hennessy, P Mark, Parker, Jr, Robert C., Santos, Edward, Brackett, Charles, Steinman, Julie D., Fenner, Jr, Melvin R., Dohrer, Kirstin, DeLorenzo, Michael, Wilhelm-Barr, Laura, Brauer, Brian R., Best-Popescu, Catherine, Durack, Gary, Wetter, Nathan, Kranz, David M., Breitbarth, Jessica, Simpson, Charlie, Pryde, Julie A., Kaler, Robin N., Harris, Chris, Vance, Allison C., Silotto, Jodi L., Johnson, Mark, Valera, Enrique Andres, Anton, Patricia K., Mwilambwe, Lowa, Bryan, Stephen P., Stone, Deborah S., Young, Danita B., Ward, Wanda E., Lantz, John, Vozenilek, John A., Bashir, Rashid, Moore, Jeffrey S., Garg, Mayank, Cooper, Julian C., Snyder, Gillian, Lore, Michelle H., Yocum, Dustin L., Cohen, Neal J., Novakofski, Jan E., Loots, Melanie J., Ballard, Randy L., Band, Mark, Banks, Kayla M., Barnes, Joseph D., Bentea, Iuliana, Black, Jessica, Busch, Jeremy, Conte, Abigail, Conte, Madison, Curry, Michael, Eardley, Jennifer, Edwards, April, Eggett, Therese, Fleurimont, Judes, Foster, Delaney, Fouke, Bruce W., Gallagher, Nicholas, Gastala, Nicole, Genung, Scott A., Glueck, Declan, Gray, Brittani, Greta, Andrew, Healy, Robert M., Hetrick, Ashley, Holterman, Arianna A., Ismail, Nahed, Jasenof, Ian, Kelly, Patrick, Kielbasa, Aaron, Kiesel, Teresa, Kindle, Lorenzo M., Lipking, Rhonda L., Manabe, Yukari C., Mayes, Jade ́, McGuffin, Reubin, McHenry, Kenton G., Mirza, Agha, Moseley, Jada, Mostafa, Heba H., Mumford, Melody, Munoz, Kathleen, Murray, Arika D., Nolan, Moira, Parikh, Nil A., Pekosz, Andrew, Pflugmacher, Janna, Phillips, Janise M., Pitts, Collin, Potter, Mark C., Quisenberry, James, Rear, Janelle, Robinson, Matthew L., Rosillo, Edith, Rye, Leslie N., Sherwood, MaryEllen, Simon, Anna, Singson, Jamie M., Skadden, Carly, Skelton, Tina H., Smith, Charlie, Stech, Mary, Thomas, Ryan, Tomaszewski, Matthew A., Tyburski, Erika A., Vanwingerden, Scott, Vlach, Evette, Watkins, Ronald S., Watson, Karriem, White, Karen C., Killeen, Timothy L., Jones, Robert J., Cangellaris, Andreas C., Martinis, Susan A., Vaid, Awais, Brooke, Christopher B., Walsh, Joseph T., Elbanna, Ahmed, Sullivan, William C., Smith, Rebecca L., Goldenfeld, Nigel, Fan, Timothy M., Hergenrother, Paul J., and Burke, Martin D.

Published
2022
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