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Background: Uses of insects to predict Post-mortem Interval (PMI) is important for non-natural causes of death such as drug abuses. Doses of drugs in a corpse are presumed to affect rates of growth and development of insects and relationships to predict the PMI. Objective: This study aims to study effects of various doses of lethal amitriptyline to the length of Calliphoridae larvae stage as the first organism seen on a corpse as well as to assess other factors involved in insect growth such temperatures and humidity. Methods: This study was an experimental research using 24 dead rats as larva’s growth media. These rats were divided into four group: the control group, the first treatment (T1) group, the second treatment (T2) group, and the third treatment (T3) group. The control group was deceased by cervical dislocation representing natural cause of death, while the treatment groups were given various doses of amitriptyline orally. The doses given to T1, T2, and T3 groups were 75 mg, 100 mg and 125 mg, respectively. Next, the rat corpses were put into cages containing Calliphoridae larvae; daily observation was conducted every morning and afternoon until the larvae transformed into pupae. All obtained data were analysed by using a multivariate linear regression analysis, Spearman correlation and Kruskal-Wallis. Results: This study showed that the more doses of amitriptyline, the longer larva cycle and the shorter length of larvae (p

Background Mobile health innovations are well adapted for ambulatory coronavirus disease 2019 (COVID-19) patients who risk clinical deterioration at home during the second week of illness. Methods A short message service (SMS) communication program was implemented by French physicians to monitor COVID-19 patients after discharge from outpatient or emergency care. The aim of the SMS tracking is to advise patients about their need for medical reassessment if reporting worsening of COVID-19 symptoms. A follow-up via SMS to all confirmed positive patients in the Nîmes area (France) was established. Every morning, patients received four follow-up questions. Daily responses were converted to green, orange or red trees, analysed in real time by physicians. “Red” patients were called immediately to check their condition and organise transfer to hospital if needed. “Orange” patients were called within two hours to verify whether the specific instructions following the SMS had been followed. Results From March 21 to June 30, 2020, 1007 patients agreed to sign up to the SMS tracking, 62% were women and the mean age was 41.5 years (standard deviation (SD) 16.0). During follow-up, 649 (64%) became “orange” and 69 (7%) “red”. Ten patients were directly admitted to the Infectious Diseases Department during their follow-up due to clinical worsening, all but one as a result of SMS alerts and subsequent telephone assessment by physicians. Conclusion SMS tracking platforms could be useful as an early warning system to refer patients with worsening clinical status to hospital-based care or additional clinician advice.

In 1842, when John Goodsir was Conservator to the Museum of the RCSEd, he saw a 19-year-old male patient who vomited a large volume of acidic, fermented-smelling, watery fluid every morning. Under his microscope, Goodsir found the vomitus to be populated with a micro-organism he named Sarcina ventriculi, which he considered to be causative. In so-doing, Goodsir became one of the first people to link a specific micro-organism with a disease. Goodsir recommended small doses of creosote as an antiseptic and claimed that the boy was eventually cured of the vomiting condition. In August of 1863 Charles Darwin was hugely celebrated by the scientific community and the public, but he had suffered from severe stomach problems all his adult life and at this point, he was vomiting daily. He read Goodsir’s paper and contacted him and asked if he could send some vomitus samples to Edinburgh in the hope that Goodsir might find Sarcina in it and solve the mystery of his debilitating stomach symptoms and perhaps cure them with creosote. Goodsir examined samples in his microscope, but failed to find Sarcina. Sadly, Darwin went on to suffer constantly from severe stomach problems, recently attributed to lactose intolerance, until he died in 1882, some 20 years later.

En estos 85 años de existencia, cada mañana cuando el sol despunta en el horizonte, la Escuela Naval de Suboficiales ARC “Barranquilla” inicia nuevos retos. Todos los días existen nuevas metas que alcanzar. Algunas de ellas son de carácter inmediato y se constituyen en labores que mantienen a la institución unida por fines nobles hacia nuestra patria Colombia.

> If you think about the unthinkable long enough it becomes quite reasonable. > > Josephine Tey (1896–1952)British author Have you ever thought about what our life as specialists for rheumatic diseases will look like in 2049? The amount of data gathered from us and our patients is increasing exponentially, and eventually, these data will be used to improve and facilitate patient’s care. We, that means primarily rheumatologists and—as the responsibilities will also change with all data —all other health professionals involved in the care of patients with rheumatic diseases, should know what to expect and actively contribute to this process. It is 10:00 on a sunny 21 July in 2049 and you are currently at your most favourite place in the world: a small cottage in the mountains, a vineyard in France or your house with a breath-taking view of the sea. You just finished your morning round on your virtual ward and a glimpse at your computer shows that 99% of the 50 000 customers in your virtual practice do not have any complaints and are enjoying their life without health-related limitations. In fact, most of them have never even had any symptoms as they were diagnosed before disease manifestation and preventive measures have successfully been applied. Like every morning, the system reports a few patients that deviate from their normal status. In some patients, the system has already adapted or changed therapy or has given behavioural advice. Most patients do not need any further adjustments. The system has identified two customers who need personal assessment in your virtual clinic, and therefore, an appointment has already been made. Other patients are still on your agenda for the virtual expert meeting this afternoon, as they do not fit into the known disease entities or treatment standards. Your avatar will present these complex cases to the other …

We aimed to verify the effect of new low-sodium high-potassium seasonings and processed foods containing poly-γ-glutamic acid on blood pressure in free-living settings. To this end, we conducted a randomized, double-blind controlled trial on 187 Japanese men, aged 35–67 years, who did not use antihypertensives. Participants were randomly allocated to an intervention (n = 93) or a control group (n = 94). They were given a boxed lunch and miso soup (average Na and K content for the intervention group: 1175 and 1476 mg, for the control group: 2243 and 703 mg, respectively). Blood pressure was measured three times every morning for 1 week immediately before and during the final week of the trial. On the day before and the final day of the intervention period, 24 h urine samples were collected. After intervention, the intervention group showed a significantly stronger decrease in the urinary sodium-to-potassium ratio than the control group (p &lt, 0.001). The mean difference in systolic blood pressure change after adjustment for baseline values between the two groups was −2.1 (95% CI: −3.6, −0.6) mmHg. Compliance between the groups was similar, suggesting successful blinding. In conclusion, the use of new seasonings and processed foods aimed at lowering blood pressure in free-living settings may be feasible and effective.

To ensure health maintenance of young athletes, immunological stress due to physical exercise has to be balanced for performance development and health maintenance. Sleep is an important influencing factor for immune regulation because of its regenerating effect. In an attempt to assess overnight immune regulation, this observational study aimed to examine associations between changes in capillary immunological blood markers and measures of sleep in adolescent athletes. Over a period of three nights, 12 male (n= 6) and female (n= 6) adolescent track and field athletes aged 16.4 ± 1.1 years were monitored for their sleep behavior (e.g., sleep duration, sleep depth) and immune regulation by using subjective (e.g., sleep) and objective (capillary blood markers) measurement tools. Over the 4 day (three nights), athletes followed their daily routines (school, homework, free time activities, and training). Training was performed for different disciplines (sprint, hurdles, and long-jump) following their daily training routines. Training included dynamic core stability training, coordination training, speed training, resistance training, and endurance training. Capillary blood samples were taken 30–45 min after the last training session (10:00–12:00 a.m. or 5:00–6:00 p.m.) and every morning between 7:00 and 10:00 a.m. Changes in capillary blood markers from post-training to the next morning and morning-to-morning fluctuations in capillary blood markers were analyzed over a three-night period using a generalized estimating equations (GEE) statistical approach. Associations of overnight changes with measures of sleep were analyzed using GEE. We found significant decreases in white blood cell count (WBC), granulocytes (GRAN), granulocytes% (GRAN%), monocytes (MID), and granulocyte-lymphocyte-ratio. In contrast, lymphocytes% (LYM%) increased significantly and systemic inflammation index showed no difference from post-training to the next morning. Furthermore, there was a significant decrease in WBC and GRAN between morning 1 and morning 3. At morning 4, values returned to baseline (morning 1), irrespective if athletes performed a training session or rested on day 3. Furthermore, sleep duration was significantly and negatively associated with changes in WBC (βz= −0.491) and lymphocytes (βz= −0.451). Our results indicate that overnight sleep duration is an important parameter of immunological overnight regulation for adolescent athletes.

This paper adopts the lens of social media rituals to study a new incarnation of ritualized greetings: good morning memes. These are a popular yet under-studied form of ritualized greeting posted every morning by social media users across the global. Such memes feature text with a wish for the incoming day paired with elements such as flowers, food or animals. In this paper, I focus on the ways in which these memes construct values, broadly defined as guiding beliefs about the desirable. My analysis is based on a sample of 414 good morning memes posted to Instagram in English and Italian. I conducted a content analysis examining the posts for content (protagonist and background), the main values conveyed (e.g. achievement and self-efficacy, happiness and positivity), and their stance (serious or ironic). A preliminary analysis revealed strong consistency in the dataset. Overall, good morning memes embed the general mandate for “politeness” that infuses the communicative genre of greetings, transposing it in the meme format through impersonal messages and a saccharine aesthetic. Furthermore, the memes voice a shared core of values, namely: “Happiness and positivity” and “performative kindness.” However, the English and Italian subsets also diverge in significant ways. The English language version of the meme upholds the value of “achievement and self-efficacy,” possibly because of the influence of American values on globalized social media content. Conversely, the Italian-language version of the meme uses humor to pushback against the idea that the morning is a time to be energetic and productive.

The abuse and distribution of narcotics in the city of Medan have been very worrying lately, almost all groups are the target, especially teenagers and young people, Narcotics include extraordinary crimes (extraordinary crime) that are very destructive than physical and mental than the next generation of the nation. Therefore a rehabilitation center that meets standards is needed. Rehabilitation is an effort to restore and restore the condition of victims and drug abuse to return to physical, psychological, social and spiritual health. So far the Ummi House rehabilitation center has not been optimal. The method of this routine activity is: Every morning wake up, the residents/clients are obliged to carry out morning prayers in congregation and prayer five times, holding recitals. For this reason, a Chancellor and Worship Practice program is required and other activities are closed at 10 pm. There is no time left, all the time utilized in the framework of resident recovery. The results of this Activity Program to Clients / Rehabilitated Patients are a healthy condition and can return to normal functioning in daily life. And do not return to using the Drug.

Hemingway’sconcentration on his writing was unflagging. Once he and Hadley had determined that his work would be fiction writing, she took on as many of the household responsibilities as she could. Hemingway rented a small room near their apartment and set off every morning soon after breakfast —in fact, he asked Hadley that breakfast itself be silent so that his concentration from the time he awoke would be uninterrupted.1 As he worked on the stories that would become part of his In Our Time manuscript, he mined sources of the valuable emotion Stein had suggested would give him momentum. The brief character sketches from his Petoskey and Chicago days were long gone; in his 1922 and 1923 stories, Hemingway was creating more complex webs of both character and theme.

Effects of two different management systems on male dromedary camel hormones, behaviors, and semen parameters were documented. Camels (n=6) were tested under two management systems: (i) housed in single boxes with 1-h freedom (H23); (ii) exposed to females for 17 h (from 3.30 p.m. to 8.30 a.m.) and then housed (ConExF). Blood was collected every morning; camel behavior was recorded twice a day: (i) from 7:00 to 8:00 a.m. to determine the short effects; (ii) from 2:00 to 3:00 p.m. to determine the long effects. Each camel underwent a female parade and semen collection thrice a week; sexual behavior, libido, and semen parameters were assessed. Testosterone and cortisol concentrations were higher in ConExF than H23. Compared to the H23 group, ConExF group spent more time walking, standing tripods, and looking outside their pen/box but they spent less time eating, ruminating, resting, standing, and showing stereotypical behaviors. In the morning, ConExF group spent more time walking, ruminating, and showing typical sexual behaviors compared to themselves during afternoon time and the H23 group. However, in the afternoon time, ConExF camels put more time their heads outside the box through the window and showed higher frequencies of stereotypies, probably due to a higher level of frustration. While the sexual behavioral score was higher and ejaculates showed a higher fraction of milky white and white-colored semen in ConExF than H23 group, their libido was similar. Overall, 17 h of exposure led to an increase in testosterone and cortisol levels, enhancing sexual behavior and semen color, but leading to frustration. Supplementary Information The online version contains supplementary material available at 10.1007/s11250-021-02702-6.

Japanese morning drama series (asadora) are considered one of the “flagships” of Japan’s state broadcaster NHK, because this format has barely changed since its start in the 1960s and still attracts millions of viewers every morning. In this chapter, we investigate the origins of tourism induced by these morning drama series, its first peak in the 1980s, and its development until today, while drawing on the case studies of Oshin (1983/1984) as an example of the analogue age and Amachan (2013) as an example of the digital age, which both are widely regarded as two of the most successful and popular morning drama series. We will show, however, that media convergence and fandom activities were already very common before digitalization. Furthermore, both series transformed their rural filming location into a touristic resource and established a long-lasting connection to the respective media content. Besides their popularity in Japan, the two series were also spread outside of Japan as a means of soft power, and while Oshin gained attention even in the United States, Amachan became very popular in East Asia.

The aim of the present paper is to monitor changes of selected mental and physiological stress indicators in both female and male sportsmen in the subsequent days prior to an International Judo Tournament in Poland and on the competition day. The study included 9 men and 9 women, participants of the training camp that ended with a tournament. Every morning, on the three consecutive days preceding the competition (day -3, -2, -1) and on the competition day (day 0) capillary blood was sampled to determine serum cortisol (C) and testosterone (T) levels, then the subjects assessed their night sleep quality (SQ) with the use of a 5-point Likert scale, and perceived anxiety using the State-Trait Anxiety Inventory questionnaire by Spielberger (STAI - Polish version). SQ insignificantly deteriorated, and C and anxiety levels increased with the time to event. The inter-group analysis for the entire period showed higher scores in average anxiety and higher average level of C in women than men. The relative changes in these biomarkers could indicate higher pre-competitive stress in women, however without taking into account the sports class of the opponents individually for each of the groups one cannot imply gender-specific susceptibility to stress as a general principle.

More than 4000 beard samples were collected from a single person every morning over a 12-year period and analyzed using a standard-free method. We detected significant annual variations in the concentrations of magnesium and calcium in the study period, although significant monthly and seasonal variations were not noted. Calcium tends not to be obtained from season-specific foods or drinks, so its variations may be affected by changes in the metabolism of the body. In contrast, however, potassium showed marked long-term variations with significant seasonal differences. As our previous studies confirmed that green vegetables contain large quantities of potassium and that their supply and consumption increase from May to July, the seasonal variations in potassium concentration were attributed to the ingestion of green vegetables. Although magnesium is also contained in green vegetables in large quantities, its principle supply sources are diverse and its concentration did not show any clear seasonal changes.

Every morning, we prayed at the shrine. Most villagers do just that, asking for health, blessing and good fortune for their activities of day. We, having money, were expected to offer sacrifices too. Most villagers are too poor to do so on a daily basis and we were expected to pick up some of the slack. Every morning we purchased gin, chalk, and kola nuts, sometimes ourselves from various individuals that sold sacred commodities, sometim...

Purpose: We aimed to investigate the effects of soybean diet and back massage on the neck skin of middle-aged women. Methods: Enrolled subjects were classified into four groups (n=10 each): control (Cont), soybean diet (SD; ingested 50 g soybean every morning), back massage (BM; received a 30 min back massage twice a week), and soybean diet and back massage (SDBM; ingested soybean and received a 30 min back massage twice a week). Changes in sebum, moisture, and pH levels and in the melanin and erythema indices of the neck skin were measured before and 12 weeks after the experiment. Results: The sebum and moisture levels showed significant increase in all groups. The Cont group subjects showed a significant increase in the melanin and erythema indices but a decrease in pH. The SD group subjects had significantly reduced pH and melanin index; however, the change in the erythema index was not significant. The BM group subjects showed significantly decreased pH and erythema index; however, the change in the melanin index was not significant. Further, the SDBM group subjects had significant decrease in pH and melanin and erythema indices. Conclusion: Middle-aged women in the SDBM group experienced the greatest benefits on the neck skin. The combinatorial effect of SD and BM may be useful as an indicator for changes in the body and have a role in further research.

Some people dream of success, while others get up every morning and make it happen. As a child, Prof. Ammar Ahmed Chaudhry had seen his parents struggle with complex medical conditions. Seeing his mother go through a series of complicated biopsies, he started out to pursue the possibility of “virtual biopsy”, which is defined as biological profiles of specific tumors that may help predict a patient’s response to treatment and probability of long-term survival, and decided to enter the field of diagnostic and interventional radiology.

Objective. The aim of this prospective cohort study, performed during a 10 d training camp, was to analyze the effect of a series of successive speed-power training sessions on the concurrent circadian changes in resting leg skin temperature and blood creatine kinase (CK) levels and to determine the correlation between them. Approach. Seventeen elite sprinters, aged 22–31 years, were examined. Every morning and evening, capillary blood samples were drawn to assay CK levels. Lower limb skin temperature was measured simultaneously, and thermal images were taken using an infrared camera. Main results. From the first day of the training camp, the base temperature levels began to drop to obtain a significant reduction from the 6th day (male) and from the 8th day (female) to the end of the camp. Simultaneously, CK levels increased in the male group from 8th to the end of the camp, but it did not change significantly in females. Regarding the circadian rhythm, the CK levels always rose during the day and declined during the night. The temperature decreased during the day and increased during the night until the 6th day. After that, the temperature changed oppositely till the end of camp, i.e. it increased during the day and decreased during the night. This could suggest that the training microcycle should last about a week because after this time there may be a disturbance in the temperature circadian rhythm and a significant CK accumulation Significance. Multi-day speed-power training induced a progressive reduction in resting skin temperature and an elevation in CK levels. It also altered the circadian rhythm of the body skin temperature, which may indicate that after about 6 d of regular exercise, physiological deregulation may occur.

Adaptive interventions are an emerging class of behavioral interventions that allow for individualized tailoring of intervention components over time to a person’s evolving needs. The purpose of this study was to evaluate an adaptive step goal + reward intervention, grounded in Social Cognitive Theory delivered via a smartphone application (Just Walk), using a mixed modeling approach. Participants (N = 20) were overweight (mean BMI = 33.8 ± 6.82 kg/m2), sedentary adults (90% female) interested in participating in a 14-week walking intervention. All participants received a Fitbit Zip that automatically synced with Just Walk to track daily steps. Step goals and expected points were delivered through the app every morning and were designed using a pseudo-random multisine algorithm that was a function of each participant’s median baseline steps. Self-report measures were also collected each morning and evening via daily surveys administered through the app. The linear mixed effects model showed that, on average, participants significantly increased their daily steps by 2650 (t = 8.25, p

Lucile woke, as she had every morning for the last five months, in the strong, warm arms of Roger. As she turned into his chest for a quick snuggle before rising, he started to wake up too, slowly at first, until finally his bright eyes came fully to life and met hers. He kissed her on the forehead. Their morning routine was always the same. Roger would bring Lucile coffee as she washed and dressed, then made her breakfast. They'd catch up on the news together and discuss their plans for the day. "We need to go shopping as your parents are coming over for dinner tonight," Roger reminded her. He never forgot anything. Lucile agreed, although she admitted she was nervous about the evening. "Don't worry, people tend to love me," he reassured her. Hand-in-hand they headed out the front door. Lucile never went anywhere without Roger. She didn't have to, because it was 2050 and Roger was a humanoid robot who didn't have anywhere else to be but right by her side for however long she wanted him there.

Most of the university students in Japan think that a morning-oriented lifestyle will be better for their health and studies. However, some of them do not have the custom to wake up before 9 am and have breakfast. Especially skipping breakfast is considered to influence badly to their stats of absence and concentration to their classes before noon. Therefore, our study’s purpose is to develop the method to promote them to switch their lifestyle to a morning-oriented lifestyle. Our proposal method consists of following 2 activities; 1) logging time of their waking up and going bed and 2) engaging an online community activity including reporting having breakfast every morning and so on. In order to examine the effectiveness of our proposal, experiment was conducted with university students not having a morning-oriented lifestyle. As a result, our method appears to be effective to let participant have a morning-oriented lifestyle. Furthermore, it seems that the settings that a member who have had such a lifestyle already is in the community as a normal member who standing same place with other members, meaning not a leader, will be more effective.

No data analytics professional comes into the office every morning and thinks, I’d like to spend a very long time producing nothing of value while costing my employer money. Despite best intentions, many data analytics projects fail or take much longer than expected to generate a positive outcome. There is no point blaming data engineers, data scientists, and data analysts. According to W. Edwards Deming, “every system is perfectly designed to get the results it gets” and “the system that people work in and the interaction with people may account for 90 or 95 percent of performance.”1

This case study reports the training of an elite 25-km open-water swimmer and the daily heart rate variability (HRV) changes during the 19-week period leading to his world champion title. Training load was collected every day and resting HRV was recorded every morning. The swimmer’s characteristics were V̇O2max: 58.5 ml·min−1·kg−1, maximal heart rate: 178 beats per minute, and maximal ventilation: 170 L·min−1. Weekly training volume was 85±21 km, 39±8% was at [La]b4 mmol·L−1 (Z3). In the supine position, the increase in training volume and Z2 training were related to increases in rMSSD and HF. In the standing position, an increase in parasympathetic activity and decrease in sympathetic activity were observed when Z1 training increased. Seasonal changes indicated higher values in the LF/HF ratio during taper, whereas higher values in parasympathetic indices were observed in heavy workload periods. This study reports extreme load of an elite ultra-endurance swimmer. Improvements in parasympathetic indices with increasing Z2 volume indicate that this training zone was useful to improve cardiac autonomic activity, whereas Z1 training reduced sympathetic activity.

Recurrent aphthous ulceration (RAU) is the most common oral mucosal disease. Some patients have almost continuous oral ulcers which influence the quality of life. The aim of this study was to observe the efficacy and safety of thalidomide on the recurrence interval of continuous RAU.A randomized controlled clinical trial was designed, and 60 continuous RAU patients were randomly assigned to the experimental group (n = 32, taking thalidomide before bed at a dose of 100 mg/d for 10 days, then 50 mg/d for 10 days, and 25 mg/d for 10 days) and the control group (n = 28, taking 0.4 mg/kg/d prednisone every morning for 15 days and then 0.2 mg/kg/d for 15 days). The clinical outcomes consisted of the primary outcome (recurrence interval) and the secondary outcomes (pain level, number of ulcers, and days for ulcer healing), and they were measured at every visit. Adverse reactions were recorded.A total of 54 and 51 patients presented at the first and second return visit, respectively. After 1 month, the increase in the recurrence interval was not shown to differ between the two groups (P = .12). However, the improvement in the recurrence interval was significantly greater in the experimental group (P .001) at the second return visit. The improvement in the secondary outcomes was identical between two groups at each return visit (P .05). The incidence of adverse reactions was similar between two groups (P = .50).Thalidomide had a long-term effect of extending the recurrence interval of continuous RAU.

Background: The therapeutic effects of fresh garlic remain controversial. The aim of this study is to investigate whether supplementation of fresh garlic could improve blood glucose and cholesterol profile in Libyan diabetic patients with moderate blood cholesterol. Methods: Forty-six diabetic patients were randomly assigned to either fresh garlic alone (≈2 grams/day), or fresh garlic in combination with glibenclamide taken on an empty stomach every morning for a month. Serum blood glucose, cholesterol and blood pressure were measured before starting treatment and after the end of the treatment period. Results: Fresh garlic alone was able to decrease the mean serum cholesterol levels by 26 mg/dl (84% of the original base values), while the combination of fresh garlic and glibenclamide produced a 28 mg/dl decrease in the mean serum cholesterol (85% of the original base values). Fresh garlic alone was able as well to decrease the mean blood glucose levels by 20 mg/dl (85% of the original base values), while the combination of fresh garlic and glibenclamide produced a 60 mg/dl decrease in the serum glucose levels (72% of the original base values). Neither treatment had a significant effect on the mean systolic or diastolic blood pressures after 30 days of treatment. Conclusion: Administration of fresh garlic every morning for a month significantly reduced the blood cholesterol and fasting blood glucose levels in diabetic patients. Thus administering dietary fresh garlic daily to diabetic patients might have cardio-protective effects on diabetic patients.

Daily covariation of three sleep indicators (quantity, quality, postsleep restedness), anxiety symptoms, and caffeine and alcohol consumption was observed in 283 emerging adults ( Mage = 19.9). Participants completed web-based sleep diary surveys every morning and evening for 7 consecutive days. Cross-lagged models suggested that sleep quality and restedness (reported each morning) predicted students’ anxiety levels (reported each evening) and that anxiety levels predicted all three sleep indicators. Furthermore, pre-bedtime caffeine consumption predicted worse sleep that night. Controlling for the effects of weekdays versus weekends produced virtually identical effects to the 7-day models, although weekend alcohol consumption emerged as a predictor of postsleep restedness. These data support bidirectionality between sleep and anxiety symptoms in emerging adults attending college/university and highlight potential avenues for intervention.

The study aimed to find out the effect of Eurycoma longifolia Jack on testosterone level and spermatozoa quality of Etawa crossbreed goat. Goats were divided into two treatment groups, three goats each. Group 1 (K1) was control group which given orally 20 ml of distilled water every morning at 9:00 am for six days, and group 2 (K2) was administered with Eurycoma longifolia with the dose of 90 mg/kg bw in 20 ml of distilled water orally every morning at 9:00 am for six days. The concentration of testosterone was measured on day 1, 3, and 6 using the method of enzyme-linked immunosorbent assay (ELISA). The quality of sperm consisted of concentration and percentage of life sperm. The results showed that level of testosterone on K2 increased started from day 1 (9.36 ng/ml) to day 6 (12.43 ng/ml) (P

Purpose:To quantify the training loads reported by karate athletes of the Brazilian national team in the week immediately before their participation in the 2015 Pan American Games.Methods:Eleven elite karate athletes (7 men and 4 women, 24.42 ± 3.75 y, 1.70 ± 0.09 m, 69.6 ± 13.2 kg) from the Brazilian national team took part in this study. Session rating of perceived exertion (s-RPE) was quantified in all training sessions. Moreover, resting heart-rate variability (HRV), as analyzed through the natural log of the root-mean-square difference of successive normal RR intervals (lnRMSSD), and countermovement-jump (CMJ) performance before and after 8 training sessions were assessed throughout the week. The differences based on magnitudes were calculated comparing pre- and posttraining session, as well as measures performed every morning during the week.Results:The weekly s-RPE was 2608.5 ± 431.2 a.u. The lnRMSSD was very likely higher on Monday than on the following days of the week, remaining stable during this period. CMJ height did not change during the week. Almost certain differences were observed in lnRMSSD pre- and posttraining session, while CMJ height did not change.Conclusions:The national karate-team athletes did not present signs of fatigue accumulation, as indicated by relatively steady HRV and unchanged CMJ during the week, as planned by the coaches for precompetition technical and tactical refinement.

Italian novelist Italo Calvino ([1972] 1974: 102–103) described Leonia as a city where ‘every morning the people wake between fresh sheets, wash with just-unwrapped cakes of soap, wear brand-new clothing, take from the latest model refrigerator still unopened tins, listening to the last-minute jingles from the most up-to-date radio’. This opulent newness is dependent upon garbage trucks collecting the remains of Yesterday’s Leonia every morning and driving it outside the city, where ‘the outflow increases and the piles rise higher, become stratified, extend over a wider perimeter’. Leonia is actually surrounded by waste, and ‘[p]erhaps the whole world, beyond Leonia’s boundaries, is covered by craters of rubbish, each surrounding a metropolis in constant eruption’. The higher the pile of rubbish that surrounds Leonia, the more the danger of a landslide looms: a tin can, an old tire, an unraveled wine flask, if it rolls toward Leonia, is enough to bring with it an avalanche of unmated shoes, calendars of bygone years, withered flowers, submerging the city in its own past, which it had tried in vain to reject, mingling with the past of the neighboring cities, finally clean. Calvino insinuated that waste waits, patiently. However, waste is already amongst us, calling into question the current institutional order of an endlessly growing linear flow of production → distribution → consumption. (Less)

Levels, compositions, sources and health risk of PM2.5-bound PAHs were measured at a regional monitoring site of Huang-gang in the winter of 2018. Samples were collected every morning, afternoon, evening and late night (LN). The average concentrations of PM2.5 and PAHs were 110.4 ± 48.3 µg m–3 and 25.6 ± 12.0 ng m–3, respectively. The concentration of PM2.5 was in the order of evening > morning > afternoon > LN, while PAHs concentration was in the order of evening > LN > morning > afternoon. According to PM2.5 concentration and its changing trend, the haze can be divided into three stages: early (low concentration, January 13–15, EHZ), medium (high concentration, January 16–22, MHZ) and late (concentration decreased rapidly, January 23–24, LHZ). A positive correlation (P < 0.01) was observed between PM2.5 and ∑16PAHs concentration only in MHZ. Besides, PAHs concentration was positively related to NOx concentration, CO concentration and temperature but negatively correlated with RH, independent of O3 concentration. The ratios of OC/EC indicated that the secondary aerosol had a great influence on the formation of haze. Three sources of PAHs including traffic emission, coal combustion and biomass combustion were extracted and quantified, accounting for 54.4%, 13.3% and 32.3% of PAHs, respectively. Potential source contribution function (PSCF) and concentration weighted trajectory (CWT) indicated the transmission of PM2.5 from Wuhan and local pollutant emission were crucial to the formation of haze. BaPeq concentration combined with ILCR values was used to evaluate health risk and the results showed this haze had potential health risk to both adults and children.

It turns out that if you’re lucky enough to be long-lived and intellectually brilliant; and if you wake every morning at 5:30 a.m. with curiosity and energy and your thinking cap on, willing to put...

A private catering company almost every day serves processed fried food every morning, afternoon and evening. However, this often gets complaints from customers such as an itchy throat and fear of high cholesterol. The Spinner Pulling Oil tool is an automatic oil slicer that utilizes centrifugal force and is a solution to this problem. The purpose of this study was to determine what percentage of the ability of an ergonomic spinner tool can reduce oil content in food processing and to determine the time efficiency for the use of a spinner in draining processed fried food. The research methodology used is quantitative and qualitative where the types of fried foods that were tested were bakwan, fried onions and fried tempeh. From the research that has been done, it is found that the Spinner tool can reduce the oil content contained in fried food by 30% for Bakwan, 38% for Tempe and 45% for fried onions. This ergonomic Spinner provides up to 100% time efficiency for all types of food studied

Objective/backgroundWrist-worn sleep actigraphs are limited for evaluating sleep, especially in sleepers who lie awake in bed without moving for extended periods. Sleep logs depend on the accuracy of perceiving and remembering times of being awake. Here we evaluated pressing an event-marker button while lying awake under two conditions: self-initiated pressing every 5 to 10 minutes or pressing when signaled every 5 minutes by a vibration pulse from a wristband. We evaluated the two conditions for acceptability and their concordance with actigraphically scored sleep.Participants and methodsTwenty-nine adults wore actigraphs on six nights. On nights 1 and 4, they pressed the marker to a vibration signal, and on nights 2 and 5, they self-initiated presses without any signal. On nights 3 and 6, they were told not to press the marker. Every morning they filled out a sleep log about how they had slept.ResultsThe vibration band was unacceptable to 42% of the participants, who judged it too disturbing to their sleep. Self-initiated pressing was acceptable to all, although it reduced log reported sleep depth compared to a no pressing condition. Estimations of sleep onset latency were considerably longer by button pressing than by actigraphy. Agreement of epoch-by-epoch sleep scoring by actigraphy and by button pressing was poor (kappa = 0.23) for self-initiated pressing and moderate (kappa = 0.46) for pressing in response to a vibration.ConclusionsSelf-initiated button pressing to indicate being awake while lying in bed is acceptable to many, interferes little with sleep, and adds substantially to the information given by actigraphy.

We have reached the great episode of the manna. The phenomenon of the “manna” is a sweet and aromatic resin produced by two parasites of a plant (tamarix mammifera) in the central area of the Sinai. Coming from Egypt, the people could not know the manna, and so they ask, ‘What is it?’. And Moses answers and explains. Without the eyes and words of the prophets our ‘What is it?’-s remain unanswered, or, more simply, we seek and we find other cheap answers that leave us hungry. The greatest form of free gift is the one that comes down from heaven every morning together with the dew. The world is surrounded by gratuitousness. In fact, it is more real and present than evil that is also present. It dwells in our midst, we can find it in the trees, in our families, in the bushes, under our warehouses and offices, in the markets, in the streets, in hospitals, in schools and deep in the hearts of our people. It is here, in the amazement of ordinariness, that we may find the type of gratuitousness that saves us. Crossing our deserts would be much more bearable if only we knew how to recognize, with the help of the eyes of the prophets, the providence that surrounds us, that we can feed and that feeds us.

Easy Internet access and social media have had a tremendous impact on contemporary society, penetrating almost every aspect of life and creating new business and economic models. Much of ones daily activities require being active online, from answering work emails to e-learning, shopping, booking medical appointments or online banking. Every morning before 9 a.m. most people would have already read about events around the globe, sent a message to a friend on Facebook, or spent £100 without even leaving the house.

During my more intensive writing sessions at a local bakery, I am surrounded by sounds. My most creative periods tend to be in the morning. It seems as if my muses leave me around 2:00 pm, so I make sure to set aside at least an hour of writing every morning. The morning crowd at the bakery contains a set of regular patrons gathered in small little groups. The conversation in these morning groups tends to be quite casual. After having listened to their words and studied their gestures on numerous occasions, it appears as if the conversations are about the previous day’s events or some local issue. The largest group, usually about ten older gentlemen, are typically located near the middle of the bakery. A smaller group of women sit themselves near the window and occasionally find themselves conversing about the people walking by the windows. Finally, the third group sits near my favorite writing spot. I try to locate myself off to the far side of the bakery. Away from windows and the central area of the bakery, my choice of writing location is based on minimizing visual and auditory distractions. This third group sits behind me, and their conversations are focused on religion. A dedicated Bible group, they meet almost daily to quietly discuss issues regarding their most recent readings.

Now I will begin to describe Luker’ia Vasil’evna Kalmykova’s visits to the Doukhobors who lived in Elizavetpol’ guberniia. I remember three visits. Luker’ia Vasil’evna always stayed with the Verigins. Our mother was Petr Larionovich Kalmykov’s aunt. Thus Luker’ia Vasil’evna visited her as the aunt of her late husband. Her first visit was when Petr Vasil’evich and I were children. I remember how every morning she invited us to her room and asked us to stand beside her, with arms folded on our chests. This was in preparation to read the children’s psalms. And we began to recite them. When we finished she thanked us and said, “These are clever boys.” And she gave us candies and nuts. We bowed in thanks and left in triumph.

Benjamin Franklin allegedly said, “I wake up every morning at nine and grab for the morning paper. Then I look at the obituary page. If my name is not on it, I get up.” What are we to make of this humorous, yet dark comment? At a deeper level it may indicate the way Franklin would like to be remembered. He may have been asking himself what his obituary would look like. Would people remember him positively or negatively?

OBJECTIVE To pilot test a new closed-loop control technology to validate it for a further large clinical trial. RESEARCH DESIGN AND METHODS The t:slim X2 insulin pump with Control-IQ Technology (Tandem Diabetes Care) includes a Dexcom G6 sensor and a closed-loop algorithm implemented in the pump that 1) automates insulin correction boluses, 2) has a dedicated hypoglycemia safety system, and 3) gradually intensifies control overnight, aiming for blood glucose levels of approximately 100–120 mg/dL every morning. RESULTS Five patients with type 1 diabetes (mean age 52.8 years, 2/3 male/female, mean A1C 6.5%) used Control-IQ in an outpatient setting (hotel) for approximately 37 h. During the closed loop, mean glucose was 129 mg/dL (135/121 mg/dL during the day/night), time within target range 70–180 mg/dL was 87% (82%/94% during the day/night), and time CONCLUSIONS Following this pilot trial, Control-IQ was deployed in several studies, including the large-scale National Institutes of Health International Diabetes Closed-Loop (iDCL) Trial.

BACKGROUND The aim of this study is to clarify associations between orthostatic blood pressure (BP) change, as well as possible physiological factors, and day-to-day home BP variability, a promising risk factor for cardiovascular outcomes. METHODS Study participants were 6,465 community residents (age 58.3 years). Home BP was measured every morning and evening for 7 days. Orthostatic BP was calculated as the maximum difference between BP measured while sitting and remeasured after 1 and 3 minutes standing. RESULTS Frequency of individuals who showed orthostatic BP decline was as follows: systolic BP (SBP) change ≥−20 mm Hg: 2.6%, ≥−10 mm Hg: 14.1%. These subgroups showed larger home SBP variability (average real variability: 11.3 ± 5.3, 8.7 ± 3.9 mm Hg) when compared with orthostatic normotensives (7.6 ± 3.7 mm Hg) (all P < 0.001). Multiple linear regression analysis adjusted for major covariates, including seated BP, identified orthostatic BP drop as an independent determinant for morning BP variability (≥−20 mm Hg: β = 0.037, P = 0.003; ≥−10 mm Hg: β = 0.026, P = 0.036) but not for evening BP variability. Carotid hypertrophy was significantly associated with home BP variability (morning: β = 0.052, P = 0.001; evening: β = 0.065, P < 0.001) and showed a U-shaped association with orthostatic BP change. Plasma B-type natriuretic peptide level, a previously suggested factor for BP variability, did not show significant association with morning and evening BP variability. CONCLUSION Orthostatic BP decline was significantly associated with morning BP variability. Large artery atherosclerosis was a common risk factor.

Fenwick Gibsen ate breakfast with his wife each and every morning before commuting to his office. Suzannah Gibsen, Fenwick well knew, was a bit of a retro health nut; in fact, to say “a bit” was to understate the matter rather dramatically. She insisted on each of them consuming, side by side in their bay-windowed, east-facing breakfast room, at sunrise, a bowl filled with a mountain of crisp blueberries, under a layer of strawberries, atop a mound of oat brain suffused with an ample, underlying lake of fat-free (and, for that matter, lactose-free) milk. A tall glass of antioxidant-fortified fresh-squeezed orange juice (with one crystal-clear ice cube of distilled water) was also obligatory, as was a large, steaming cup of Jamaican Blue Mountain coffee, black. The kicker was that Suzannah insisted that all this food come from the soil in the old-fashioned way; no replicator-produced victuals for her and her famous husband. Fenwick had long ago given up trying to point out to his better half that molecules were molecules, whether they found their final arrangement over time in an old-millennium garden, or were configured in seconds in a replicator. Suzannah insisted that grown food was healthier, and she pointed out that she’d been right about berries and caffeine. And, she had been right: The recommendations that had surfaced at about the start of the new millennium had turned out to have unusual staying power, supported at this point (2029) by a veritable ocean of empirical data. Those recommendations had been to consume cancer-fighting berries, Alzheimer-fighting caffeine, and a host of other things that Fenwick now dutifully ingested every day of his life. (Red wine, also powerfully salubrious in moderation, was something Fenwick was allowed to have only when socializing with other members of the literati. Fenwick had long ago let fall the objection that his wine cellar, worth a pretty penny, would take a century to enjoy at the Suzannah-prescribed rate of consumption.) When spooning down the cocktail Suzannah prescribed, he routinely fantasized about the day when cures for all forms of cancer would finally be found. On that glorious day, he would be able to revert to a breakfast of cheddar-infused scrambled eggs, sausage, bacon, and greasy home fries, all produced in under three seconds by a replicator.

Purpose To investigate if generic Wondfo ovulation sticks (WLH) are sufficiently sensitive to the luteinizing hormone (LH) surge in urine when used with the Marquette Fertility Algorithm. The electronic hormonal fertility monitor (EHFM) is highly accurate in detecting the LH surge but cost of the monitor and the accompanying test sticks has increased over the last several years. The EHFM is sensitive to detect the LH surge at 20 milli-international units per milliliter (mIU/mL); the WLH sticks are slightly less sensitive at 25 mIU/mL. Study design and methods A convenience sample of women using the Marquette Method of Natural Family Planning with the EHFM to avoid pregnancy were recruited (N = 54). Each participant used the EHFM every morning after cycle day 6 and tested morning and evening urine with the WLH stick until the day following detection of the LH surge on the EHFM. Results Forty-two women provided 219 cycles. Frequency of LH surge detection was 182/219 (83.1%) for EHFM and 203/219 (92.7%) for WLH sticks. Agreement between the EHFM and the WLH on the day of the LH surge was 97.7%. High fertility readings providing a warning of peak fertility at least 5 days before peak was 67% for the WLH; the EHFM was 47.7%. Paired sample correlations for high fertility was .174 (p = .014) and paired sample differences t was -4.729 (p = .000). Clinical implications The WLH stick is sufficiently sensitive to use in place of the EFHM for determining peak fertility and with the Marquette Fertility algorithm. Even with minimal use, WLH sticks cost about half the price of the monitor strips and provide more flexibility of use. Cost differences increase with the number of sticks used per cycle. Further research with a larger sample is needed to verify results.

Every morning I face the pleasant task of selecting a coffee mug from a cabinet shelf crowded with mismatched options. I have collected the assorted mugs over decades, and each carries with it a unique set of memories that mark its individual history with me. Therefore, the morning ritual involves more than the utilitarian activity of finding a vessel for coffee; opening the cabinet door is like encountering a collection of memories. These ordinary objects have been much on my mind.

Every morning on my way into work I pass a building that has, for as long as I can remember, bothered me. Bristol Dogs and Cats Home has, for me at least, been symbolic of abandonment, of grief, an...

Recovery is essential for high athletic performance, and therefore especially sleep has been identified as a crucial source for physical and psychological well-being. However, due to early-morning trainings, which are general practice in many sports, athletes are likely to experience sleep restrictions. Therefore, this study investigated the sleep-wake patterns of 55 junior national rowers (17.7 ± 0.6 years) via sleep logs and actigraphy during a four-week training camp. Recovery and stress ratings were obtained every morning with the Short Recovery and Stress Scale on a 7-point Likert-type scale ranging from 0 (does not apply at all) to 6 (fully applies). The first training session was scheduled for 6:30 h every day. With two to four training sessions per day, the training load was considerably increased from athletes' home training. Objective sleep measures (n = 14) revealed less total sleep time (TST) in the first two weeks (409.6 ± 19.1 and 416.0 ± 16.3 min), while training volume and intensity were higher. In the second half of the camp, less training sessions were implemented, more afternoons were training free and TSTs were longer (436.3 ± 15.8 and 456.9 ± 25.7 min). A single occasion of 1.5-h delayed bedtime and usual early morning training (6:30 h) resulted in reduced ratings of Overall Recovery (OR) (M = 3.3 ± 1.3) and greater Negative Emotional State (NES) (M = 1.3 ± 1.2, p < .05), which returned to baseline on the next day. Following an extended night due to the only training-free day, sleep-offset times were shifted from ~5:30 to ~8:00 h, and each recovery and stress score improved (p < .01). Moreover, subjective ratings of the first six days were summarised as a baseline score to generate reference data as well as to explore the association between sleep and recovery. Intercorrelations of these sleep parameters emphasised the relationship between restful sleep and falling asleep quickly (r = .34, p < .05) as well as few awakenings (r = .35, p < .05). Overall, the findings highlight the impact of sleep on subjective recovery measures in the setting of a training camp. Providing the opportunity of extended sleep (and a day off) seems the most simple and effective strategy to enhance recovery and stress-related ratings.

Every morning the Balinese pedanda siwa, who is usually termed in the Western literature a “high priest” or a “Brahmana priest,” performs a series of rituals known to Balinese and to Western scholars alike as “surya-sevana”. These important rituals, which form the basis of the pedanda’s practice, have been interpreted by Western scholars in widely divergent ways. Some scholars have regarded the rites as constituting a cult of sun worship (e.g. Brunner 1967:409-410). They have been judged to b...

In June 2012, I spent a week on Davidson Glacier, above Haines, Alaska. Seven of us formed two rope teams of climbers, learning how to travel safely across a big river of ice. Every morning for seven days, we roped up and snowshoed across the glacier, then strapped on crampons and climbed up unnamed peaks of the Chilkat Range. Late every afternoon, we would trudge back to camp across the glacier, barely lifting our feet and listening to the shuffle of the snowshoes. The sun stayed out most of the night, but it didn’t stop us from sleeping soundly. One evening we were following our own snowshoe tracks back to camp after a long day of climbing. Suddenly, we all saw a distinct set of large tracks running right across our snowshoe prints from the morning. The wide paw tracks were the size of a human hand, and in the ice, you could see pads and claw marks, three middle ones very sharp. The tracks spread far apart, and they ran in a clear line from a ridge to the south of us, across the expanse of the glacier, toward a mountain that our instructors called The Dragon. Wolverine. It was as if you could see the intensity of the animal, an animal maybe 35 pounds or more, loping across the glacier from one mountain range to another, covering as much as 40 miles in a given day. The wolverine didn’t need snowshoes or crampons or ropes; his equipment was built in. Some of my companions may have been as awe-struck as I was. It was the first time any of us had seen tracks of a wolverine, and certainly the closest I had come to one. The tracks were exciting; they made me look across at The Dragon and wonder if we could ever climb it like the wolverine. We crossed the ice to camp with renewed energy

I really hope that I had not written up this memorial article—never—just as we do not worry about missing the sight of sunlight when we wake up every morning, or we stretch out our hands for help and somebody would hold them. We are not concerned too much, as though we should enjoy endless plenty of friendship, love, and salvation in life. I was wrong…

(1) Staging of BP. I routinely use ambulatory or home monitoring to stage BP, because the office BP often overor underestimates out-of-office BP. I generally initiate antihypertensive therapy if the average awake BP is Z135/ 85 mmHg or the average sleeping BP is Z125/75 mmHg. Most private insurance plans will reimburse ambulatory monitoring, but Medicare will not except for suspected white-coat hypertension, the criteria for which are so rigorous as to make this impractical for older Medicare beneficiaries who would benefit most. For home BP, the key is to calibrate the patient's monitor in the office against careful manual readings. Home BP monitors are graded by the British Hypertension Society on the dabl Education Trust website (http://www.dableducational.org/). I instruct patients to take a set of three readings every morning before taking their pills and again every evening for 4 days in a row, and then provide me with all of the readings. I discard the first day's readings and the first reading of each set as being artificially high and average the rest, if the mean is Z135/85 mmHg, I diagnose and treat hypertension. (2) Global CV risk. I use the new 2013 ACC/AHA Pooled Cohort calculator to estimate 10-year cardiovascular risk to decide about starting concomitant statin therapy, which is indicated in 475% of my hypertensive patients. I also