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1,447 results on '"Evers, B. Mark"'

8. Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells

Author

Gedaly, Roberto, Cornea, Virgilius, Turcios, Lilia, Edmisson, Jacob S., Harris, Dwight D., Watt, David S., Chapelin, Fanny, Khurana, Aman, Mei, Xiaonan, Liu, Chunming, Taylor, Isaac, Gonzalez-Valdivieso, Juan, Mitchel, Hunter, Ruffing, Alexis, Chishti, Asir, Orozco, Gabriel, Zwischenberger, Joseph, Evers, B. Mark, and Marti, Francesc

Published
2022
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15. Overexpression of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth.

Author

Drury, James, Geisen, Mariah E., Tessmann, Josiane Weber, Rychahou, Piotr G., Kelson, Courtney O., He, Daheng, Wang, Chi, Evers, B. Mark, and Zaytseva, Yekaterina Y.

Subjects
FATTY acid synthases, COLORECTAL cancer, INHIBITION of cellular proliferation, TUMOR growth, N-acetylglucosamine, GLUTAMINE synthetase, GLUTATHIONE transferase
Abstract

Fatty acid synthesis has been extensively investigated as a therapeutic target in cancers, including colorectal cancer (CRC). Fatty acid synthase (FASN), a key enzyme of de novo lipid synthesis, is significantly upregulated in CRC, and therapeutic approaches of targeting this enzyme are currently being tested in multiple clinical trials. However, the mechanisms behind the pro-oncogenic action of FASN are still not completely understood. Here, for the first time, we show that overexpression of FASN increases the expression of glutamine–fructose-6-phosphate transaminase 1 (GFPT1) and O-linked N-acetylglucosamine transferase (OGT), enzymes involved in hexosamine metabolism, and the level of O-GlcNAcylation in vitro and in vivo. Consistently, expression of FASN significantly correlates with expression of GFPT1 and OGT in human CRC tissues. shRNA-mediated downregulation of GFPT1 and OGT inhibits cellular proliferation and the level of protein O-GlcNAcylation in vitro, and knockdown of GFPT1 leads to a significant decrease in tumor growth and metastasis in vivo. Pharmacological inhibition of GFPT1 and OGT leads to significant inhibition of cellular proliferation and colony formation in CRC cells. In summary, our results show that overexpression of FASN increases the expression of GFPT1 and OGT as well as the level of protein O-GlcNAcylation to promote progression of CRC; targeting the hexosamine biosynthesis pathway could be a therapeutic approach for this disease. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer

Author

Mani, Rajesh, primary, Martin, Chloe G., additional, Balu, Kanal E., additional, Wang, Qingding, additional, Rychahou, Piotr, additional, Izumi, Tadahide, additional, Evers, B. Mark, additional, and Suzuki, Yasuhiro, additional

Published
2024
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19. Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling

Author

Li, Chaohao, primary, Allison, Derek B., additional, He, Daheng, additional, Mao, Fengyi, additional, Wang, Xinyi, additional, Rychahou, Piotr, additional, Imam, Ibrahim A., additional, Kong, Yifan, additional, Zhang, Qiongsi, additional, Zhang, Yanquan, additional, Liu, Jinghui, additional, Wang, Ruixin, additional, Rao, Xiongjian, additional, Wu, Sai, additional, Evers, B. Mark, additional, Shao, Qing, additional, Wang, Chi, additional, Li, Zhiguo, additional, and Liu, Xiaoqi, additional

Published
2023
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37. Data from Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Author

Guo, Lichao, primary, Zhang, Wen, primary, Xie, Yanqi, primary, Chen, Xi, primary, Olmstead, Emma E., primary, Lian, Mengqiang, primary, Zhang, Baochen, primary, Zaytseva, Yekaterina Y., primary, Evers, B. Mark, primary, Spielmann, H. Peter, primary, Liu, Xifu, primary, Watt, David S., primary, and Liu, Chunming, primary

Published
2023
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38. Supplementary Data from Potent Synergistic Effect on C-Myc–Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor

Author

Xie, Yanqi, primary, Zhang, Wen, primary, Guo, Lichao, primary, Kril, Liliia M., primary, Begley, Kristin L., primary, Sviripa, Vitaliy M., primary, Chen, Xi, primary, Liu, Xifu, primary, Lee, Eun Y., primary, He, Daheng, primary, Wang, Chi, primary, Gao, Tianyan, primary, Liu, Xiaoqi, primary, Evers, B. Mark, primary, Watt, David S., primary, and Liu, Chunming, primary

Published
2023
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40. Supplementary Data from Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Author

Guo, Lichao, primary, Zhang, Wen, primary, Xie, Yanqi, primary, Chen, Xi, primary, Olmstead, Emma E., primary, Lian, Mengqiang, primary, Zhang, Baochen, primary, Zaytseva, Yekaterina Y., primary, Evers, B. Mark, primary, Spielmann, H. Peter, primary, Liu, Xifu, primary, Watt, David S., primary, and Liu, Chunming, primary

Published
2023
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41. Supplementary Figure 3 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors

Author

Valentino, Joseph D., primary, Li, Jing, primary, Zaytseva, Yekaterina Y., primary, Mustain, W. Conan, primary, Elliott, Victoria A., primary, Kim, Ji Tae, primary, Harris, Jennifer W., primary, Campbell, Katherine, primary, Weiss, Heidi, primary, Wang, Chi, primary, Song, Jun, primary, Anthony, Lowell, primary, Townsend, Courtney M., primary, and Evers, B. Mark, primary

Published
2023
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42. Supplementary Table from Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy

Author

Zhang, Zhuangzhuang, primary, Cheng, Lijun, primary, Li, Jie, primary, Qiao, Qi, primary, Karki, Anju, primary, Allison, Derek B., primary, Shaker, Nuha, primary, Li, Kunyu, primary, Utturkar, Sagar M., primary, Atallah Lanman, Nadia M., primary, Rao, Xiongjian, primary, Rychahou, Piotr, primary, He, Daheng, primary, Konieczny, Stephen F., primary, Wang, Chi, primary, Shao, Qing, primary, Evers, B. Mark, primary, and Liu, Xiaoqi, primary

Published
2023
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43. Supplementary Data from Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Author

Wei, Ruozheng, primary, Zhou, Yuning, primary, Li, Chang, primary, Rychahou, Piotr, primary, Zhang, Shulin, primary, Titlow, William B., primary, Bauman, Greg, primary, Wu, Yuanyuan, primary, Liu, Jinpeng, primary, Wang, Chi, primary, Weiss, Heidi L., primary, Evers, B. Mark, primary, and Wang, Qingding, primary

Published
2023
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45. Supplementary Figure 5 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors

Author

Valentino, Joseph D., primary, Li, Jing, primary, Zaytseva, Yekaterina Y., primary, Mustain, W. Conan, primary, Elliott, Victoria A., primary, Kim, Ji Tae, primary, Harris, Jennifer W., primary, Campbell, Katherine, primary, Weiss, Heidi, primary, Wang, Chi, primary, Song, Jun, primary, Anthony, Lowell, primary, Townsend, Courtney M., primary, and Evers, B. Mark, primary

Published
2023
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46. Supplementary Figure 4 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors

Author

Valentino, Joseph D., primary, Li, Jing, primary, Zaytseva, Yekaterina Y., primary, Mustain, W. Conan, primary, Elliott, Victoria A., primary, Kim, Ji Tae, primary, Harris, Jennifer W., primary, Campbell, Katherine, primary, Weiss, Heidi, primary, Wang, Chi, primary, Song, Jun, primary, Anthony, Lowell, primary, Townsend, Courtney M., primary, and Evers, B. Mark, primary

Published
2023
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47. Supplementary Figure 2 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors

Author

Valentino, Joseph D., primary, Li, Jing, primary, Zaytseva, Yekaterina Y., primary, Mustain, W. Conan, primary, Elliott, Victoria A., primary, Kim, Ji Tae, primary, Harris, Jennifer W., primary, Campbell, Katherine, primary, Weiss, Heidi, primary, Wang, Chi, primary, Song, Jun, primary, Anthony, Lowell, primary, Townsend, Courtney M., primary, and Evers, B. Mark, primary

Published
2023
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49. Data from Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Author

Wei, Ruozheng, primary, Zhou, Yuning, primary, Li, Chang, primary, Rychahou, Piotr, primary, Zhang, Shulin, primary, Titlow, William B., primary, Bauman, Greg, primary, Wu, Yuanyuan, primary, Liu, Jinpeng, primary, Wang, Chi, primary, Weiss, Heidi L., primary, Evers, B. Mark, primary, and Wang, Qingding, primary

Published
2023
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50. Supplementary Figure 1 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors

Author

Valentino, Joseph D., primary, Li, Jing, primary, Zaytseva, Yekaterina Y., primary, Mustain, W. Conan, primary, Elliott, Victoria A., primary, Kim, Ji Tae, primary, Harris, Jennifer W., primary, Campbell, Katherine, primary, Weiss, Heidi, primary, Wang, Chi, primary, Song, Jun, primary, Anthony, Lowell, primary, Townsend, Courtney M., primary, and Evers, B. Mark, primary

Published
2023
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