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1. Contents Vol. 211, 2005

Author

Christos C. Zouboulis, M. Monika Weber, Selim Aractingi, Venkata Putcha, Isabelle Daigle, M.A. Duchosal, J.L. Arranz López, Hiroyuki Matsue, E. Gambillara, Jann Lübbe, D.A. Fairhurst, P. Dellamonica, Christian Surber, Dominique Bonneau, Emmanuel Laffitte, Olivier Sorg, Katrin Kerl, Dan Lipsker, Karin Thoss, Wolfram Sterry, Henrik Møller, Maria Morales, E. Counillon, Alice Quinart, P. Del Giudice, Andreas J. Bircher, Mohammad Reza Fallahi, Agustin Llopis, Uwe Trefzer, Alexander C. Katoulis, Jean-Hilaire Saurat, Nicholas G. Stavrianeas, Jørn Olsen, Marc Buffet, Pierre Carraux, Thomas J. Brill, N. Kunzle, Mohammad Nikbakhsh, Hans-Peter Baum, J.-H. Saurat, Ambros Hügin, M. Grelier, Paulette Bioulac-Sage, Naohito Hatta, Farshad Farnaghi, Lutz Kowalzick, Philippe Revel, Carol M. Artlett, Gholamhosein R. Omrani, T. Rodriguez Bravo, Sébastien Lepreux, Katharina Spanaus Schlapbach, Carolina Pellanda, Günter Burg, Günther F.L. Hofbauer, Christine Labreze, N. Widmer, H. Zeller, Jürgen Quietzsch, Hassan Seirafi, A. Carlotti, I. Schuffenecker, Sylvie De Maricourt, Luca Borradori, Rahman Nazari, Sofia Georgala, Roland Blum, Laurence Doelker, Christian Tran, Emmanuel Molinari, Christophe Antille, Jürgen Lademann, Akiko Nagasaka, I. Masouyé, P. Lesavre, Mitra Amini, J.-M. Pönnighaus, Renato G. Panizzon, Amin Parhizgar, L.A. Decosterd, H. Zachariae, Daniel Mischke, S.M. Clark, Julie De Quatrebarbes, E. Laffitte, Ute Jacobi, Evelyne Leemans, Giovanni Luigi Capella, Diamant Thaçi, Nicolas Dupin, Hans-Uwe Simon, Reinhard Dummer, Eva M. Valesky, Julien Gautier, Denise Grand, Behrooz Kasraee, Jörg Willers, Thierry André, F. Vandenbos, T. Kovacsovics, Parisa Mansoori, Aiko Miyahara, Heidrun Ziegler, L. Garcia Martinez, Gürkan Kaya, Shinji Shimada, Julien Autier, J.-P. Venetz, Farhad Handjani, M. Pascual, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Regina Treudler, Martine Neau-Cransac, Pierre Vabres, E. Elena Sorando, Maryam Akhyani, Jean Saric, Helen S. Evans, Isabelle Gorin, and Silvio Hemmi

Subjects
Dermatology
Published
2005
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2. Effect of Intense Pulsed-Light Exposure on Lipid Peroxides and Thymine Dimers in Human Skin In Vivo

Author

Jean-Hilaire Saurat, Christophe Antille, Elizabeth Masgrau, Pierre Carraux, Denis Salomon, Victor Janer, Olivier Sorg, and Evelyne Leemans

Subjects
Adult, Lipid Peroxides, Adolescent, medicine.medical_treatment, Pyrimidine dimer, Human skin, Dermatology, Intense pulsed light, Ultraviolet A Radiation, chemistry.chemical_compound, Nuclear magnetic resonance, medicine, Humans, Skin, Lipid peroxide, business.industry, General Medicine, Middle Aged, Thymine, Biochemistry, chemistry, Pyrimidine Dimers, Intense Pulsed Light Therapy, sense organs, business, Visible spectrum
Abstract

Background Intense pulsed light (IPL) generates high-intensity short flashes of visible light and has been used for about 10 years to improve dermatological conditions such as telangiectasia, pigmented lesions, and skin aging. Although these systems deliver a moderate dose (10-30 J/cm 2 ) of visible light, this dose is delivered during a short pulse (2-5 milliseconds), which implies a very high fluence rate (approximately 4000 W/cm 2 ). For this reason, we speculated whether the Bunsen-Roscoe law of reciprocity could still be valid in these conditions. Observations Nine healthy volunteers were exposed to IPL or UV-A or simulated solar UV radiation, and then thymine dimer and lipid peroxide concentrations were determined in skin biopsy specimens of the exposed sites. Only exposure to solar UV radiation (7-J/cm 2 UV-A + 80-mJ/cm 2 UV-B) produced measurable amounts of thymine dimers in DNA from skin biopsy specimens, whereas UV-A radiation (40 J/cm 2 ) and IPL (9 J/cm 2 ) induced 3-fold and 6-fold increases of cutaneous lipid peroxides, respectively. Conclusions These preliminary results indicate that IPL, although filtered for wavelengths shorter than 500 nm, can generate oxidative stress, a typical hallmark of UV-A, but does not induce thymine dimers. This emphasizes the need for long-term studies involving IPL before using this technique in a recurrent manner.

Published
2007
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3. Topical calcineurin inhibitors decrease the production of UVB-induced thymine dimers from hairless mouse epidermis

Author

Jann Lübbe, Gürkan Kaya, Christophe Antille, Laurence Doelker, Evelyne Leemans, Denise Grand, Pierre Carraux, Jean-Hilaire Saurat, Christian Tran, and Olivier Sorg

Subjects
Ratón, Ultraviolet Rays, medicine.medical_treatment, Calcineurin Inhibitors, Pyrimidine dimer, Apoptosis, Dermatology, Biology, Administration, Cutaneous, Tacrolimus, chemistry.chemical_compound, Mice, medicine, Animals, Enzyme Inhibitors, Skin, Mice, Hairless, Epidermis (botany), Immunosuppression, Biological activity, Peptidylprolyl Isomerase, Hairless, Thymine, Calcineurin, surgical procedures, operative, chemistry, Pyrimidine Dimers, Immunology, Liposomes, Cancer research, Pharmaceutical Vehicles, Sunscreening Agents, DNA Damage
Abstract

Background: An increased incidence of ultraviolet-light-related skin tumours is a well-known problem in patients undergoing posttransplantation immunosuppression with systemic calcineurin inhibitors such as cyclosporine A or tacrolimus. UV-related carcinogenesis as a consequence of long-term treatment of sun-exposed sites with topical calcineurin inhibitors is therefore of theoretical concern. Results: In this study, we show that tacrolimus acts as a UVB filter when incorporated into liposome membranes. In hairless mice pretreated with 1% pimecrolimus cream, 0.1% tacrolimus ointment or vehicle, the amount of epidermal thymine dimers, measured 1 h after 1 J/cm2 of UVB irradiation, was decreased by 89, 84 and 47%, respectively, as compared to untreated mice. Forty-eight hours after UVB irradiation, 97, 89 and 93% of epidermal thymine dimer levels were removed in pimecrolimus-, tacrolimus- or vehicle-treated mice, respectively. In contrast, 69% of thymine dimers, originally present in much higher amounts than in treated mice, were removed from untreated controls. UVB-induced apoptosis was less pronounced in treated mice. Conclusion: Taken together, these results suggest that topical calcineurin inhibitors prevent DNA photodamage due to a filter effect of both vehicle and active components, whereas they do not affect the clearance of DNA photoproducts.

Published
2005

4. Subject Index Vol. 211, 2005

Author

P. Del Giudice, Ambros Hügin, Marc Buffet, Regina Treudler, T. Rodriguez Bravo, Arash Taheri, Carolina Pellanda, Thomas J. Brill, Martine Neau-Cransac, Andreas J. Bircher, Emmanuel Molinari, Jørn Olsen, E. Gambillara, Olivier Sorg, J.-M. Pönnighaus, Christophe Antille, Paulette Bioulac-Sage, Denise Grand, Thierry André, Alexander C. Katoulis, I. Masouyé, M.A. Duchosal, Julie De Quatrebarbes, H. Zachariae, Henrik Møller, Alice Quinart, S.M. Clark, Amin Parhizgar, Giovanni Luigi Capella, Hans-Uwe Simon, Carol M. Artlett, M. Grelier, Julien Gautier, Selim Aractingi, Gürkan Kaya, Sébastien Lepreux, Julien Autier, Pierre Vabres, Mohammad Reza Fallahi, Jean-Hilaire Saurat, J.-P. Venetz, I. Schuffenecker, M. Monika Weber, Daniel Mischke, Maryam Akhyani, Günther F.L. Hofbauer, Venkata Putcha, Pierre Carraux, Farhad Handjani, Akiko Nagasaka, E. Counillon, Diamant Thaçi, Jann Lübbe, Farshad Farnaghi, Lutz Kowalzick, M. Pascual, Christian Surber, Dominique Bonneau, Dan Lipsker, Emmanuel Laffitte, Katrin Kerl, T. Kovacsovics, Roland Kaufmann, Thomas Elshorst-Schmidt, Agustin Llopis, Hassan Seirafi, Jörg Willers, Luca Borradori, Parisa Mansoori, Shinji Shimada, Heidrun Ziegler, L.A. Decosterd, N. Kunzle, Rahman Nazari, Sofia Georgala, Christine Labreze, F. Vandenbos, Jürgen Lademann, Nicolas Dupin, Behrooz Kasraee, Christos C. Zouboulis, Isabelle Daigle, P. Lesavre, Mitra Amini, Hiroyuki Matsue, Uwe Trefzer, Philippe Revel, Nicholas G. Stavrianeas, J.L. Arranz López, Karin Thoss, Jürgen Quietzsch, Sylvie De Maricourt, D.A. Fairhurst, P. Dellamonica, Renato G. Panizzon, Hans-Peter Baum, Reinhard Dummer, Ute Jacobi, Evelyne Leemans, Helen S. Evans, Maria Morales, Eva M. Valesky, Isabelle Gorin, Katharina Spanaus Schlapbach, N. Widmer, Laurence Doelker, Christian Tran, Wolfram Sterry, Aiko Miyahara, L. Garcia Martinez, Roland Blum, Silvio Hemmi, E. Elena Sorando, Jean Saric, H. Zeller, E. Laffitte, Gholamhosein R. Omrani, Mohammad Nikbakhsh, A. Carlotti, J.-H. Saurat, Naohito Hatta, and Günter Burg

Subjects
Index (economics), Statistics, Subject (documents), Dermatology, Mathematics
Published
2005
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5. Acknowledgement to Referees for Dermatology 2005

Author

M. Grelier, Denise Grand, Thierry André, Paulette Bioulac-Sage, Henrik Møller, Thomas J. Brill, Regina Treudler, Pierre Carraux, Sébastien Lepreux, Carol M. Artlett, Christophe Antille, I. Masouyé, Silvio Hemmi, Amin Parhizgar, Alice Quinart, Gholamhosein R. Omrani, S.M. Clark, D.A. Fairhurst, P. Del Giudice, Ambros Hügin, E. Elena Sorando, A. Carlotti, Nicholas G. Stavrianeas, Martine Neau-Cransac, P. Dellamonica, Jean Saric, Farshad Farnaghi, I. Schuffenecker, Emmanuel Laffitte, Katrin Kerl, Lutz Kowalzick, Marc Buffet, Selim Aractingi, M. Monika Weber, Julien Autier, L.A. Decosterd, Christine Labreze, J.-P. Venetz, Agustin Llopis, Aiko Miyahara, Jürgen Quietzsch, Sylvie De Maricourt, Rahman Nazari, Sofia Georgala, Nicolas Dupin, Venkata Putcha, E. Laffitte, L. Garcia Martinez, Hans-Peter Baum, Maria Morales, Hassan Seirafi, Behrooz Kasraee, Diamant Thaçi, Jann Lübbe, Luca Borradori, Christian Surber, Dominique Bonneau, Laurence Doelker, Christian Tran, E. Counillon, F. Vandenbos, Dan Lipsker, Günter Burg, Gürkan Kaya, Renato G. Panizzon, Helen S. Evans, Ute Jacobi, Evelyne Leemans, Eva M. Valesky, Mohammad Reza Fallahi, Katharina Spanaus Schlapbach, Roland Blum, Isabelle Gorin, N. Widmer, Reinhard Dummer, J.L. Arranz López, M.A. Duchosal, Karin Thoss, Wolfram Sterry, Carolina Pellanda, H. Zeller, Shinji Shimada, Emmanuel Molinari, Akiko Nagasaka, J.-M. Pönnighaus, T. Kovacsovics, Julie De Quatrebarbes, Daniel Mischke, Mohammad Nikbakhsh, Giovanni Luigi Capella, Hans-Uwe Simon, J.-H. Saurat, Julien Gautier, Naohito Hatta, Jörg Willers, Heidrun Ziegler, Günther F.L. Hofbauer, Philippe Revel, N. Kunzle, Pierre Vabres, P. Lesavre, Mitra Amini, Maryam Akhyani, Farhad Handjani, M. Pascual, Jürgen Lademann, Uwe Trefzer, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Andreas J. Bircher, Parisa Mansoori, Jørn Olsen, Hiroyuki Matsue, E. Gambillara, Alexander C. Katoulis, Jean-Hilaire Saurat, H. Zachariae, Isabelle Daigle, T. Rodriguez Bravo, Christos C. Zouboulis, and Olivier Sorg

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2005
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