1,079 results on '"Evans DA"'
Search Results
2. Importance of Formic Acid in Various Ethological States of Oecophylla smaragdina (Fabricius)
- Author
-
Vidhu, VV, Evans, DA, and Chakravarthy, Akshay Kumar, editor
- Published
- 2015
- Full Text
- View/download PDF
3. Bisphenol A acts as developmental agonist in Culex quinquefasciatus Say
- Author
-
Ayana Gayathri and Evans Da
- Subjects
Agonist ,endocrine system ,Bisphenol A ,Ecdysone ,medicine.drug_class ,Health, Toxicology and Mutagenesis ,Mosquito Vectors ,Biology ,Pharmacology ,chemistry.chemical_compound ,Phenols ,medicine ,Animals ,Environmental Chemistry ,Benzhydryl Compounds ,urogenital system ,fungi ,Water ,General Medicine ,biology.organism_classification ,Pollution ,Culex quinquefasciatus ,Culex ,Ecdysterone ,chemistry ,Phospholipases ,Larva ,Plastics - Abstract
Plastic – derived Bisphenol A (BPA) contaminated sewages in Trivandrum, Kerala, India are mosquito breeding sites. After summer rain, BPA in the stagnant water samples ranged between 0.86 and 1.14ppm. 1.0 ppm BPA is considered as environmentally relevant concentration. Present study revealed that BPA is a developmental agonist of Culex quinquefasciatus. Embryonic and larval development are shortened by BPA but pupal development is unaffected. Under the atmospheric temperature of 26 to 310C lifecycle was completed within 312 hours but during summer it was completed within 278 hours, meanwhile atmospheric temperature ranged between 30 and 370C. Reduction in the duration of development due to BPA was 50 to 70 hours during summer and 60 to 80 hours in other seasons. Larval – pupal stadium of the mosquito has three surges of 20-hydroxy ecdysone(20-HE), at 24,32 and 48th hour of the 4th instar. BPA resulted dose-dependent advancement of 20-HE peaks, Phospholipase A2 induction and expression of Ecdysone receptor EcRA and Ecdysone inducible gene E75A, which culminated in early pupation. Adults emerging from 1.0 ppm BPA treatment did not show significant difference in sanguivory and fecundity compared to control but pupae developed in 2 and 4 ppm BPA were significantly small.
- Published
- 2022
4. Maintaining mobility in late life. I. Demographic characteristics and chronic conditions.
- Author
-
Guralnik, JM, LaCroix, AZ, Abbott, RD, Berkman, LF, Satterfield, S, Evans, DA, and Wallace, RB
- Subjects
Clinical Research ,Aging ,Quality Education ,Activities of Daily Living ,Age Factors ,Aged ,Aged ,80 and over ,Chronic Disease ,Female ,Humans ,Locomotion ,Longitudinal Studies ,Male ,Proportional Hazards Models ,Risk Factors ,Socioeconomic Factors ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
To assess the role of demographic factors and chronic conditions in maintaining mobility in older persons, this study utilized longitudinal data collected as part of the Established Populations for Epidemiologic Studies of the Elderly between 1981 and 1987 on 6,981 men and women aged 65 years and older in East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven, Connecticut. Results are presented for those who at baseline reported intact mobility, defined as the ability to climb stairs and walk a half mile without help, and who were followed annually for up to 4 years for changes in mobility status. Age, income, education, and chronic conditions present at baseline and occurring during follow-up were evaluated for their association with loss of mobility. Over the follow-up period, 55.1% of subjects maintained mobility, 36.2% lost mobility, and 8.7% died without evidence of mobility loss prior to death. In both men and women, increasing age and lower income levels were associated with increased risk of losing mobility, even after controlling for the presence of chronic conditions at baseline. After adjustment for age, income, and chronic conditions, lower education levels were a significant risk factor for mobility loss in men, but not in women. Baseline reports of previous heart attack, stroke, high blood pressure, diabetes, dyspnea, and exertional leg pain were associated with small but significant risks for mobility loss. There was a stepwise increase in the risk of mobility loss according to the number of chronic conditions present at baseline that was very consistent between men and women. The occurrence during the study of a new heart attack, stroke, cancer, or hip fracture was associated with a substantially greater risk of mobility loss than was associated with the presence of these conditions at baseline.
- Published
- 1993
5. Light to Moderate Alcohol Consumption and Mortality in the Elderly
- Author
-
Scherr, PA, LaCroix, AZ, Wallace, RB, Berkman, L, Curb, JD, Cornoni-Huntley, J, Evans, DA, and Hennekens, CH
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Aging ,Substance Misuse ,Cardiovascular ,Clinical Research ,Alcoholism ,Alcohol Use and Health ,2.4 Surveillance and distribution ,Aetiology ,Cancer ,Good Health and Well Being ,Activities of Daily Living ,Age Factors ,Aged ,Alcohol Drinking ,Boston ,Cardiovascular Diseases ,Confounding Factors ,Epidemiologic ,Connecticut ,Female ,Geriatric Assessment ,Humans ,Iowa ,Logistic Models ,Male ,Neoplasms ,Population Surveillance ,Prevalence ,Prospective Studies ,Sex Factors ,Medical and Health Sciences ,Geriatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
ObjectiveTo determine whether there is a relationship of low to moderate alcohol consumption with cardiovascular mortality in the elderly.DesignProspective cohort studies with 5-year mortality follow-up.SettingThree populations of community-dwelling elders.ParticipantsPopulation-based cohorts of men and women, aged 65 or older, in three populations. Subjects with prior myocardial infarction, stroke, or cancer, as well as those lacking alcohol consumption data, were excluded from statistical analyses leaving 2,694 subjects in East Boston, Massachusetts, 2,293 subjects in Iowa, and 1,904 subjects in New Haven, Connecticut.Main outcome measurementsAlcohol consumption, total mortality, cardiovascular mortality, and cancer mortality.ResultsLow to moderate alcohol consumption was associated with statistically significant lowered total as well as cardiovascular mortality in East Boston and New Haven. The relative risks of total mortality for low to moderate consumers of alcohol compared to those consuming no alcohol in the previous year were 0.7 (95% CI 0.6-0.8) in East Boston and 0.6 (95% CI 0.5-0.8) in New Haven. For cardiovascular mortality, the RRs were 0.6 in East Boston and 0.5 in New Haven (95% CI's exclude null). These results persisted after control for potential confounding variables. In Iowa, there were no significant differences in total or cardiovascular mortality according to alcohol consumption patterns. For cancer mortality, there were no significant associations with alcohol consumption in any of the three populations.ConclusionsThese data suggest that the relationship of low to moderate alcohol consumption with reduced total and cardiovascular mortality, which are well documented in middle age, also occur in older populations.
- Published
- 1992
6. Technical and economic efficiency measurement of African commercial banks using data envelopment analysis (DEA)
- Author
-
Evans Darko, Nadia Saghi-Zedek, and Gervais Thenet
- Subjects
Business records management ,HF5735-5746 - Abstract
The paper aims to analyze the Technical Efficiency of 70 Commercial banks from 19 African countries from 2009-2020. Using the Data Envelopment Analysis (DEA) method of the two main approaches, Variable Return to Scale (VRS) and Constant Return to Scale (CRS) technique on a Panel Data. We find that African banks have a higher efficacy assessment with the VRS than the CRS technique, thus, with a Pure Technical Efficiency (PTE) score than Technical Efficiency (TE) . Our findings show that the majority of the banks are operating at very low levels of efficiency (not technically efficient), and inability to optimize the conversion of bank assets and liabilities into loan production for customers. Furthermore, the banks are operating inefficiently in scale, economic, and allocative manner due to mismatches in scale of production. Considering these findings, the implications of these inefficiencies extend to the overall economic development and financial stability of the region.
- Published
- 2025
- Full Text
- View/download PDF
7. Perfil clínico e sucesso na extubação de pacientes pós cirurgia cardíaca
- Author
-
Sandra Omizzollo, Clarissa Rodrigues de Assis, Cristiane Aparecida S. Saraiva, Luiz Felipe Fröhlich, Cláudia Kist Fortino, and Racquel Evans da Silva
- Subjects
Occupational Therapy ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Abstract
INTRODUÇÃO: Pacientes submetidos à cirurgia cardíaca necessitam de ventilação mecânica invasiva após o procedimento cirúrgico. A extubação no pós-operatório quando bem-sucedida, está relacionada com menor tempo de internação, redução de custos e recursos utilizados e diminuição das taxas de morbimortalidade. OBJETIVO: Identificar o perfil e o número de reintubações de pacientes submetidos a cirurgias cardíacas. MATERIAIS E MÉTODOS: Estudo quantitativo, transversal retrospectivo, com coleta de dados secundários obtidos de prontuários eletrônicos em um Hospital Municipal da Região Metropolitana de Porto Alegre/RS. Foram incluídos 57 prontuários de pacientes submetidos a cirurgia cardíaca entre janeiro e dezembro de 2017 e excluídos aqueles com idade menor que 18 anos e/ou extubados previamente no bloco cirúrgico. RESULTADOS: A amostra foi composta por 22 mulheres (38,6%) e 35 homens (61,4%), com média de idade 61,60±12,33 anos. Foram realizadas 37 cirurgias de revascularização do miocárdio (64,9%), sendo sete destas associadas a troca valvar. Em relação ao desmame, 96,5% dos pacientes obtiveram sucesso na extubação, 77,2% ficaram um período menor que 24 horas em ventilação mecânica invasiva e 15,8% foram reintubados. A média de tempo de internação hospitalar foi de 22,77±17 dias e na Unidade de Terapia Intensiva de 8,53 dias, sendo que 80,7% dos pacientes tiveram alta desta unidade. CONCLUSÃO: A caracterização clínica, sociodemográfica e cirúrgica dos pacientes submetidos a cirurgia cardíaca se assemelha aos achados na literatura, uma prevalência de pacientes idosos e do sexo masculino e baixa taxa de reintubação.
- Published
- 2020
8. Understanding sexuality by rural elderly women
- Author
-
Nidiane Evans da Silva Cabral, Claudia Feio da Maia Lima, Maria da Conceição Costa Rivemales, Uilma Santos de Souza, and Bárbara Martins Corrêa da Silva
- Subjects
Rural Population ,Gerontology ,Saúde da Mulher ,Rural Area ,Anciano ,RT1-120 ,Women’s Health ,Unidad Básica de Salud ,Human sexuality ,Nursing ,Área Rural ,03 medical and health sciences ,Elderly ,0302 clinical medicine ,medicine ,Humans ,Basic Health Unit ,Medio Rural ,030212 general & internal medicine ,Meaning (existential) ,Sexualidad ,Qualitative Research ,General Nursing ,Aged ,Disappointment ,030504 nursing ,Unidade Básica de Saúde ,Salud de la Mujer ,Pessoa Idosa ,Middle Aged ,humanities ,Spouse ,Sexualidade ,Female ,Rural area ,Descriptive research ,Thematic analysis ,medicine.symptom ,0305 other medical science ,Psychology ,Sexuality ,Qualitative research - Abstract
Objective: to understand the meaning of sexuality by rural elderly women. Method: a qualitative exploratory and descriptive research, carried out through interview at the home with 26 rural elderly women, aged between 60 and 69 years. The data were analyzed by the thematic content analysis technique of Bardin. Results: understanding sexuality is linked to the construction of sexual and/or loving relationship, and positive and negative factors that interfere with the exercise of sexuality: good relationship with the spouse, physical and mental benefits, chronological age, health problems, no spouse, sexual disinterest and fear of relating for fear or disappointment. Final considerations: there is a decline in the maintenance of sexuality linked to the end of the reproductive period, to the advancing age and the low social perspective that is common for rural elderly women. RESUMEN Objetivo: comprender el significado de la sexualidad por las ancianas que viven en el medio rural. Método: la investigación de abordaje cualitativo, de carácter exploratorio y descriptivo, realizada por medio de entrevista en el domicilio a 26 ancianas de medio rural, con edad entre 60 y 69 años. Los datos fueron analizados por la técnica de análisis de contenido temático de Bardin. Resultados: la comprensión de la sexualidad se atreve a la construcción de la relación sexual y/o amorosa, ya los factores positivos y negativos que interfieren en el ejercicio de la sexualidad: buena relación con el cónyuge, beneficios físicos y mentales, edad cronológica, problemas de salud, ausencia de cónyuge, desinterés sexual y temor a relacionarse por miedo o decepción. Consideraciones finales: existe un declive del mantenimiento de la sexualidad, vinculado al final del período reproductivo, al avanzar de la edad y la baja perspectiva social, común para ancianas en medio rural. RESUMO Objetivo: compreender o significado da sexualidade por idosas que vivem em área rural. Método: pesquisa de abordagem qualitativa, de caráter exploratório e descritivo, realizada por meio de entrevista no domicílio a 26 idosas de área rural, com idade entre 60 e 69 anos. Os dados foram analisados pela técnica de análise de conteúdo temática de Bardin. Resultados: a compreensão da sexualidade atrela-se à construção da relação sexual e/ou amorosa, e aos fatores positivos e negativos que interferem no exercício da sexualidade: bom relacionamento com o cônjuge, benefícios físicos e mentais, idade cronológica, problemas de saúde, ausência de cônjuge, desinteresse sexual e receio de se relacionar por medo ou decepção. Considerações finais: existe um declínio da manutenção da sexualidade, atrelado ao fim do período reprodutivo, ao avançar da idade e à baixa perspectiva social, comum para idosas em área rural.
- Published
- 2019
9. Cerebral small vessel disease genomics and its implications across the lifespan
- Author
-
Sargurupremraj, M, Suzuki, H, Jian, X, Sarnowski, C, Evans, TE, Bis, JC, Eiriksdottir, G, Sakaue, S, Terzikhan, N, Habes, M, Zhao, W, Armstrong, NJ, Hofer, E, Yanek, LR, Hagenaars, SP, Kumar, RB, van den Akker, EB, McWhirter, RE, Trompet, S, Mishra, A, Saba, Y, Satizabal, CL, Beaudet, G, Petit, L, Tsuchida, A, Zago, L, Schilling, S, Sigurdsson, S, Gottesman, RF, Lewis, CE, Aggarwal, NT, Lopez, OL, Smith, JA, Valdés Hernández, MC, van der Grond, J, Wright, MJ, Knol, MJ, Dörr, M, Thomson, RJ, Bordes, C, Le Grand, Q, Duperron, MG, Smith, AV, Knopman, DS, Schreiner, PJ, Evans, DA, Rotter, JI, Beiser, AS, Maniega, SM, Beekman, M, Trollor, J, Stott, DJ, Vernooij, MW, Wittfeld, K, Niessen, WJ, Soumaré, A, Boerwinkle, E, Sidney, S, Turner, ST, Davies, G, Thalamuthu, A, Völker, U, van Buchem, MA, Bryan, RN, Dupuis, J, Bastin, ME, Ames, D, Teumer, A, Amouyel, P, Kwok, JB, Bülow, R, Deary, IJ, Schofield, PR, Brodaty, H, Jiang, J, Tabara, Y, Setoh, K, Miyamoto, S, Yoshida, K, Nagata, M, Kamatani, Y, Matsuda, F, Psaty, BM, Bennett, DA, De Jager, PL, Mosley, TH, Sachdev, PS, Schmidt, R, Warren, HR, Evangelou, E, Trégouët, DA, de Andrade, M, Basu, S, Berr, C, Brody, JA, Chasman, DI, Dartigues, JF, Folsom, AR, Germain, M, Sargurupremraj, M, Suzuki, H, Jian, X, Sarnowski, C, Evans, TE, Bis, JC, Eiriksdottir, G, Sakaue, S, Terzikhan, N, Habes, M, Zhao, W, Armstrong, NJ, Hofer, E, Yanek, LR, Hagenaars, SP, Kumar, RB, van den Akker, EB, McWhirter, RE, Trompet, S, Mishra, A, Saba, Y, Satizabal, CL, Beaudet, G, Petit, L, Tsuchida, A, Zago, L, Schilling, S, Sigurdsson, S, Gottesman, RF, Lewis, CE, Aggarwal, NT, Lopez, OL, Smith, JA, Valdés Hernández, MC, van der Grond, J, Wright, MJ, Knol, MJ, Dörr, M, Thomson, RJ, Bordes, C, Le Grand, Q, Duperron, MG, Smith, AV, Knopman, DS, Schreiner, PJ, Evans, DA, Rotter, JI, Beiser, AS, Maniega, SM, Beekman, M, Trollor, J, Stott, DJ, Vernooij, MW, Wittfeld, K, Niessen, WJ, Soumaré, A, Boerwinkle, E, Sidney, S, Turner, ST, Davies, G, Thalamuthu, A, Völker, U, van Buchem, MA, Bryan, RN, Dupuis, J, Bastin, ME, Ames, D, Teumer, A, Amouyel, P, Kwok, JB, Bülow, R, Deary, IJ, Schofield, PR, Brodaty, H, Jiang, J, Tabara, Y, Setoh, K, Miyamoto, S, Yoshida, K, Nagata, M, Kamatani, Y, Matsuda, F, Psaty, BM, Bennett, DA, De Jager, PL, Mosley, TH, Sachdev, PS, Schmidt, R, Warren, HR, Evangelou, E, Trégouët, DA, de Andrade, M, Basu, S, Berr, C, Brody, JA, Chasman, DI, Dartigues, JF, Folsom, AR, and Germain, M
- Abstract
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.
- Published
- 2020
10. Allometric relationships between stem diameter, height and crown area of associated trees of cocoa agroforests of Ghana
- Author
-
Michael Asigbaase, Evans Dawoe, Simon Abugre, Boateng Kyereh, and Collins Ayine Nsor
- Subjects
Medicine ,Science - Abstract
Abstract Allometric models which are used to describe the structure of trees in agroforestry systems are usually extrapolated from models developed for trees in forest ecosystems. This makes quantitative assessment of the functions of shade trees in agroforestry systems challenging since increased availability of light and space in these systems may induce structural differences from those growing under forest conditions. We addressed this issue by providing species-specific allometric information on the structural characteristics of associated shade trees on cocoa agroforestry systems and assessed if allometries conformed to theoretical predictions. At the plot level, stand and soil characteristics affecting tree structural characteristics were assessed. The study was conducted in cocoa agroforestry systems at Suhum, Ghana. The height-diameter at breast height (H-DBH) allometry had the best fits (R2 = 53–89%), followed by the crown area (CA)-DBH allometry (R2 = 27–87%) and then the CA-H allometry (R2 = 22–73%). In general, the scaling exponents of the CA-DBH, H-CA and H-DBH allometries conformed to the metabolic scaling theory (MST). However, both the CA-DBH and H-DBH allometries diverged from the geometric similarity model. Though forest tree species had similar crown areas as fruit trees, they were slenderer than fruit trees. Tree slenderness coefficients were positively correlated with soil P, Ca, Cu and the ratios (Ca + Mg):K, (Ca + Mg):(K + Na) and Ca:Mg, but not C:N while DBH and H were correlated with soil P and C:N ratio. Our results show that critical soil nutrients and their ratios affects shade tree structural attributes (e.g. slenderness and CA), which possibly restrict variations in species-specific allometries to a narrow range on cocoa systems. Furthermore, shade tree species richness and density are better predictors of relative canopy projection area (a proxy for shade intensity) than tree species diversity. In conclusion, the results have implications for shade tree species selection, monitoring of woody biomass and maintenance of biodiversity.
- Published
- 2023
- Full Text
- View/download PDF
11. COMPREENSÃO DE SEXUALIDADE POR HOMENS IDOSOS DE ÁREA RURAL
- Author
-
George Mariane Soares Santana, Nidiane Evans da Silva Cabral, Gleideson Cerqueira dos Santos Pereira, Raúl Fernando Guerrero Castañeda, Claudia Feio da Maia Lima, and Uilma Santos de Souza
- Subjects
Public Health, Environmental and Occupational Health ,RT1-120 ,Nursing ,General Nursing - Abstract
Objetivo: compreender o significado de sexualidade para homens idosos de área rural. Método: pesquisa de abordagem qualitativa, de caráter exploratório e descritivo, realizada com 23 homens idosos de área rural, com idade entre 60-69 anos. A coleta deu-se por meio do preenchimento de questionário de identificação socioeconômica e saúde, além de entrevista semiestruturada única, individual e no domicílio. Os dados foram analisados pela técnica de análise de conteúdo temática de Bardin. Resultados: a compreensão de sexualidade está intimamente ligada à construção da relação sexual e amorosa, com novas conformações na prática da sexualidade, e a fatores de interferência – idade cronológica e condição de saúde alterada. Conclusão: para os participantes deste estudo aparece com ênfase o significado da sexualidade associada à prática sexual em si, ao ato sexual. Entretanto, há também a compreensão mais subjetiva da sexualidade embasada na afetividade e nas relações amorosas, que inclui sentimentos, carinho, carícias e diálogo conjugal.Descritores: Sexualidade. Saúde do Homem. Saúde do Idoso. Área Rural. Estratégia de Saúde da Família.
- Published
- 2019
12. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing (vol 51, pg 414, 2019)
- Author
-
Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, ER, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, KL, Moreno-Grau, S, Olaso, R, Raybould, R, Chen, YN, Kuzma, AB, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, BN, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, GW, Garnier, JG, Harold, D, Fitzpatrick, AL, Valladares, O, Moutet, ML, Gerrish, A, Smith, AV, Qu, LM, Bacq, D, Denning, N, Jian, XQ, Zhao, Y, Del Zompo, M, Fox, NC, Choi, SH, Mateo, I, Hughes, JT, Adams, HH, Malamon, J, Sanchez-Garcia, F, Patel, Y, Brody, JA, Dombroski, BA, Naranjo, MCD, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, LB, Garzia, F, Galimberti, D, Hofer, E, Butkiewicz, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, WS, Meslage, S, Kornhuber, J, White, CC, Song, Y, Barber, RC, Engelborghs, S, Sordon, S, Voijnovic, D, Adams, PM, Vandenberghe, R, Mayhaus, M, Cupples, LA, Albert, MS, De Deyn, PP, Gu, W, Himali, JJ, Beekly, D, Squassina, A, Hartmann, AM, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, ME, Doody, RS, Munoz-Fernadez, C, Sussams, R, Lin, HH, Fairchild, TJ, Benito, YA, Holmes, C, Karamujic-Comic, H, Frosch, MP, Thonberg, H, Maier, W, Roshchupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, RM, Kilander, L, Moebus, S, Hernandez, I, Kamboh, MI, Brundin, R, Turton, J, Yang, Q, Katz, MJ, Concari, L, Lord, J, Beiser, AS, Keene, CD, Helisalmi, S, Kloszewska, I, Kukull, WA, Koivisto, AM, Lynch, A, Tarraga, L, Larson, EB, Haapasalo, A, Lawlor, B, Mosley, TH, Lipton, RB, Solfrizzi, V, Gill, M, Longstreth, WT, Montine, TJ, Frisardi, V, Diez-Fairen, M, Rivadeneira, F, Petersen, RC, Deramecourt, V, Alvarez, I, Salani, F, Ciaramella, A, Boerwinkle, E, Reiman, EM, Fievet, N, Rotter, JI, Reisch, JS, Hanon, O, Cupidi, C, Uitterlinden, AGA, Royall, DR, Dufouil, C, Maletta, RG, de Rojas, I, Sano, M, Brice, A, Cecchetti, R, St George-Hyslop, P, Ritchie, K, Tsolaki, M, Tsuang, DW, Dubois, B, Craig, D, Wu, CK, Soininen, H, Avramidou, D, Albin, RL, Fratiglioni, L, Germanou, A, Apostolova, LG, Keller, L, Koutroumani, M, Arnold, SE, Panza, F, Gkatzima, O, Asthana, S, Hannequin, D, Whitehead, P, Atwood, CS, Caffarra, P, Hampel, H, Quintela, I, Carracedo, A, Lannfelt, L, Rubinsztein, DC, Barnes, LL, Pasquier, F, Frolich, L, Barral, S, McGuinness, B, Beach, TG, Johnston, JA, Becker, JT, Passmore, P, Bigio, EH, Schott, JM, Bird, TD, Warren, JD, Boeve, BF, Lupton, MK, Bowen, JD, Proitsi, P, Boxer, A, Powell, JF, Burke, JR, Kauwe, JSK, Burns, JM, Mancuso, M, Buxbaum, JD, Bonuccelli, U, Cairns, NJ, McQuillin, A, Cao, CH, Livingston, G, Carlson, CS, Bass, NJ, Carlsson, CM, Hardy, J, Carney, RM, Bras, J, Carrasquillo, MM, Guerreiro, R, Allen, M, Chui, HC, Fisher, E, Masullo, C, Crocco, EA, DeCarli, C, Bisceglio, G, Dick, M, Ma, L, Duara, R, Graff-Radford, NR, Evans, DA, Hodges, A, Faber, KM, Scherer, M, Fallon, KB, Riemenschneider, M, Fardo, DW, Heun, R, Farlow, MR, Kolsch, H, Ferris, S, Leber, M, Foroud, TM, Heuser, I, Galasko, DR, Giegling, I, Gearing, M, Hull, M, Geschwind, DH, Gilbert, JR, Morris, J, Green, RC, Mayo, K, Growdon, JH, Feulner, T, Hamilton, RL, Harrell, LE, Drichel, D, Honig, LS, Cushion, TD, Huentelman, MJ, Hollingworth, P, Hulette, CM, Hyman, BT, Marshall, R, Jarvik, GP, Meggy, A, Abner, E, Menzies, GE, Jin, LW, Leonenko, G, Real, LM, Jun, GR, Baldwin, CT, Grozeva, D, Karydas, A, Russo, G, Kaye, JA, Kim, R, Jessen, F, Kowall, NW, Vellas, B, Kramer, JH, Vardy, E, LaFerla, FM, Jockel, KH, Lah, JJ, Dichgans, M, Leverenz, JB, Mann, D, Levey, AI, Pickering-Brown, S, Lieberman, AP, Klopp, N, Lunetta, KL, Wichmann, HE, Lyketsos, CG, Morgan, K, Marson, DC, Brown, K, Martiniuk, F, Medway, C, Mash, DC, Nothen, MM, Masliah, E, Hooper, NM, McCormick, WC, Daniele, A, McCurry, SM, Bayer, A, McDavid, AN, Gallacher, J, Mckee, AC, van den Bussche, H, Mesulam, M, Brayne, C, Miller, BL, Riedel-Heller, S, Miller, CA, Miller, JW, Al-Chalabi, A, Morris, JC, Shaw, CE, Myers, AJ, Wiltfang, J, O'Bryant, S, Olichney, JM, Alvarez, V, Parisi, JE, Singleton, AB, Paulson, HL, Collinge, J, Perry, WR, Mead, S, Peskind, E, Cribbs, DH, Rossor, M, Pierce, A, Ryan, NS, Poon, WW, Nacmias, B, Potter, H, Sorbi, S, Quinn, JF, Sacchinelli, E, Raj, A, Spalletta, G, Raskind, M, Caltagirone, C, Bossu, P, Orfei, MD, Reisberg, B, Clarke, R, Reitz, C, Smith, AD, Ringman, JM, Warden, D, Roberson, ED, Wilcock, G, Rogaeva, E, Bruni, AC, Rosen, HJ, Gallo, M, Rosenberg, RN, Ben-Shlomo, Y, Sager, MA, Mecocci, P, Saykin, AJ, Pastor, P, Cuccaro, ML, Vance, JM, Schneider, JA, Schneider, LS, Slifer, S, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tang, M, Tanzi, RE, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, CE, Yu, L, Saba, Y, Pilotto, A, Bullido, MJ, Peters, O, Crane, PK, Bennett, D, Bosco, P, Coto, E, Boccardi, V, De Jager, PL, Lleo, A, Warner, N, Lopez, OL, Ingelsson, M, Deloukas, P, Cruchaga, C, Graff, C, Gwilliam, R, Fornage, M, Goate, AM, Sanchez-Juan, P, Kehoe, PG, Amin, N, Ertekin-Taner, N, Berr, C, Debette, S, Love, S, Launer, LJ, Younkin, SG, Dartigues, JF, Corcoran, C, Ikram, MA, Dickson, DW, Nicolas, G, Campion, D, Tschanz, J, Schmidt, H, Hakonarson, H, Clarimon, J, Munger, R, Schmidt, R, Farrer, LA, Van Broeckhoven, C, O'Donovan, MC, DeStefano, AL, Jones, L, Haines, JL, Deleuze, JF, Owen, MJ, Gudnason, V, Mayeux, R, Escott-Price, V, Psaty, BM, Ramirez, A, Wang, LS, Ruiz, A, van Duijn, CM, Holmans, PA, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Lambert, JC, Pericak-Vance, MA, ADGC, EADI, Cohorts Heart Aging Res Genomic, and Genetic Environm Risk AD Defining
- Published
- 2019
13. Handbook of Plant Cell Culture. Volume 1. Techniques for Propagation and Breeding.
- Author
-
Arditti, Joseph, Nyman, Leslie P, Evans, DA, Sharp, WA, Ammirato, PV, and Yanell, Y
- Subjects
Plant Biology ,Plant Biology & Botany - Published
- 1984
14. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
- Author
-
Chauhan, G, Adams, HHH, Satizabal, CL, Bis, JC, Teumer, A, Sargurupremraj, M, Hofer, E, Trompet, S, Hilal, S, Smith, AV, Jian, X, Malik, R, Traylor, M, Pulit, SL, Amouyel, P, Mazoyer, B, Zhu, YC, Kaffashian, S, Schilling, S, Beecham, GW, Montine, TJ, Schellenberg, GD, Kjartansson, O, Guðnason, V, Knopman, DS, Griswold, ME, Windham, BG, Gottesman, RF, Mosley, TH, Schmidt, R, Saba, Y, Schmidt, H, Takeuchi, F, Yamaguchi, S, Nabika, T, Kato, N, Rajan, KB, Aggarwal, NT, De Jager, PL, Evans, DA, Psaty, BM, Rotter, JI, Rice, K, Lopez, OL, Liao, J, Chen, C, Cheng, CY, Wong, TY, Ikram, MK, van der Lee, SJ, Amin, N, Chouraki, V, Destefano, AL, Aparicio, HJ, Romero, JR, Maillard, P, Decarli, C, Wardlaw, JM, Del C. Valdés Hernández, M, Luciano, M, Liewald, D, Deary, IJ, Starr, JM, Bastin, ME, Maniega, SM, Slagboom, PE, Beekman, M, Deelen, J, Uh, HW, Lemmens, R, Brodaty, H, Wright, MJ, Ames, D, Boncoraglio, GB, Hopewell, JC, Beecham, AH, Blanton, SH, Wright, CB, Sacco, RL, Wen, W, Thalamuthu, A, Armstrong, NJ, Chong, E, Schofield, PR, Kwok, JB, van der Grond, J, Stott, DJ, Ford, I, Jukema, JW, Vernooij, MW, Hofman, A, Uitterlinden, AG, van der Lugt, A, Wittfeld, K, Grabe, HJ, Hosten, N, von Sarnowski, B, Völker, U, Levi, C, Jimenez-Conde, J, Chauhan, G, Adams, HHH, Satizabal, CL, Bis, JC, Teumer, A, Sargurupremraj, M, Hofer, E, Trompet, S, Hilal, S, Smith, AV, Jian, X, Malik, R, Traylor, M, Pulit, SL, Amouyel, P, Mazoyer, B, Zhu, YC, Kaffashian, S, Schilling, S, Beecham, GW, Montine, TJ, Schellenberg, GD, Kjartansson, O, Guðnason, V, Knopman, DS, Griswold, ME, Windham, BG, Gottesman, RF, Mosley, TH, Schmidt, R, Saba, Y, Schmidt, H, Takeuchi, F, Yamaguchi, S, Nabika, T, Kato, N, Rajan, KB, Aggarwal, NT, De Jager, PL, Evans, DA, Psaty, BM, Rotter, JI, Rice, K, Lopez, OL, Liao, J, Chen, C, Cheng, CY, Wong, TY, Ikram, MK, van der Lee, SJ, Amin, N, Chouraki, V, Destefano, AL, Aparicio, HJ, Romero, JR, Maillard, P, Decarli, C, Wardlaw, JM, Del C. Valdés Hernández, M, Luciano, M, Liewald, D, Deary, IJ, Starr, JM, Bastin, ME, Maniega, SM, Slagboom, PE, Beekman, M, Deelen, J, Uh, HW, Lemmens, R, Brodaty, H, Wright, MJ, Ames, D, Boncoraglio, GB, Hopewell, JC, Beecham, AH, Blanton, SH, Wright, CB, Sacco, RL, Wen, W, Thalamuthu, A, Armstrong, NJ, Chong, E, Schofield, PR, Kwok, JB, van der Grond, J, Stott, DJ, Ford, I, Jukema, JW, Vernooij, MW, Hofman, A, Uitterlinden, AG, van der Lugt, A, Wittfeld, K, Grabe, HJ, Hosten, N, von Sarnowski, B, Völker, U, Levi, C, and Jimenez-Conde, J
- Abstract
Objective To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. Methods We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n=20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI. Results The mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 × 10-8; and LINC00539/ZDHHC20, p = 5.82 × 10-9. Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p[BI] = 9.38 × 10-25; p [SSBI] = 5.23 × 10-14 for hypertension), smoking (p[BI]= 4.4 × 10-10; p [SSBI] = 1.2 × 10 -4), diabetes (p[BI] = 1.7 × 10 -8; p [SSBI] = 2.8 × 10 -3), previous cardiovascular disease (p [BI] = 1.0 × 10-18; p [SSBI] = 2.3 × 10-7), stroke (p [BI] = 3.9 × 10-69; p [SSBI] = 3.2 × 10 -24), and MRI-defined white matter hyperintensity burden (p [BI]=1.43 × 10-157; p [SSBI] = 3.16 × 10-106), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p ≤ 0.0022), without indication of directional pleiotropy. Conclusion In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significan
- Published
- 2019
15. Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
- Author
-
Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, ER, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, KL, Aloso, R, Raybould, R, Chen, Y, Kuzma, AB, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, BN, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, GW, Garnier, JG, Harold, D, Fitzpatrick, AL, Valladares, O, Moutet, ML, Gerrish, A, Smith, AV, Qu, L, Bacq, D, Denning, N, Jian, X, Zhao, Y, Zompo, MD, Fox, NC, Grove, ML, Choi, SH, Mateo, I, Hughes, JT, Adams, HH, Malamon, J, Garcia, FS, Patel, Y, Brody, JA, Dombroski, B, Naranjo, MCD, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, LB, Garzia, F, Galimberti, D, Hofer, E, Butkiewics, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, W, Meslage, S, Kornhuber, J, White, CC, Song, Y, Barber, RC, Engelborghs, S, Pichler, S, Voijnovic, D, Adams, PM, Vandenberghe, R, Mayhaus, M, Cupples, LA, Albert, MS, De Deyn, PP, Gu, W, Himali, JJ, Beekly, D, Squassina, A, Hartmann, AM, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, ME, Doody, RS, Fernadez, CM, Sussams, R, Lin, H, Fairchild, TJ, Benito, YA, Holmes, C, Comic, H, Frosch, MP, Thonberg, H, Maier, W, Roschupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, RM, Kilander, L, Moebus, S, Hernández, I, Kamboh, MI, Brundin, R, Turton, J, Yang, Q, Katz, MJ, Concari, L, Lord, J, Beiser, AS, Keene, CD, Helisalmi, S, Kloszewska, I, Kukull, WA, Koivisto, AM, Lynch, A, Tarraga, L, Larson, EB, Haapasalo, A, Lawlor, B, Mosley, TH, Lipton, RB, Solfrizzi, V, Gill, M, Longstreth Jr, WT, Montine, TJ, Frisardi, V, Ortega-Cubero, S, Rivadeneira, F, Petersen, RC, Deramecourt, V, Ciaramella, A, Boerwinkle, E, Reiman, EM, Fievet, N, Caltagirone, C, Rotter, JI, Reisch, JS, Hanon, O, Cupidi, C, Uitterlinden, AG, Royall, DR, Dufouil, C, Maletta, RG, Moreno-Grau, S, Sano, M, Brice, A, Cecchetti, R, St George-Hyslop, P, Ritchie, K, Tsolaki, M, Tsuang, DW, Dubois, B, Craig, D, Wu, CK, Soininen, H, Avramidou, D, Albin, RL, Fratiglioni, L, Germanou, A, Apostolova, LG, Keller, L, Koutroumani, M, Arnold, SE, Panza, F, Gkatzima, O, Asthana, S, Hannequin, D, Whitehead, P, Atwood, CS, Caffarra, P, Hampel, H, Baldwin, CT, Lannfelt, L, Rubinsztein, DC, Barnes, LL, Pasquier, F, Frölich, L, Barral, S, McGuinness, B, Beach, TG, Johnston, JI, Becker, JT, Passmore, P, Bigio, EH, Schott, JM, Bird, TD, Warren, JD, Boeve, BF, Lupton, MK, Bowen, JD, Proitsi, P, Boxer, A, Powell, JF, Burke, JR, Kauwe, JK, Burns, JM, Mancuso, M, Buxbaum, JD, Bonuccelli, U, Cairns, NJ, McQuillin, A, Cao, C, Livingston, G, Carlson, CS, Bass, NJ, Carlsson, CM, Hardy, J, Carney, RM, Bras, J, Carrasquillo, MM, Guerreiro, R, Allen, M, Chui, HC, Fisher, E, Cribbs, DH, Masullo, C, Crocco, EA, DeCarli, C, Bisceglio, G, Dick, M, Ma, L, Duara, R, Graff-Radford, NR, Evans, DA, Hodges, A, Faber, KM, Scherer, M, Fallon, KB, Riemenschneider, M, Fardo, DW, Heun, R, Farlow, MR, Ferris, S, Leber, M, Foroud, TM, Heuser, I, Galasko, DR, Giegling, I, Gearing, M, Hüll, M, Geschwind, DH, Gilbert, JR, Morris, J, Green, RC, Mayo, K, Growdon, JH, Feulner, T, Hamilton, RL, Harrell, LE, Drichel, D, Honig, LS, Cushion, TD, Huentelman, MJ, Hollingworth, P, Hulette, CM, Hyman, BT, Marshall, R, Jarvik, GP, Meggy, A, Abner, E, Menzies, G, Jin, LW, Leonenko, G, Jun, G, Grozeva, D, Karydas, A, Russo, G, Kaye, JA, Kim, R, Jessen, F, Kowall, NW, Vellas, B, Kramer, JH, Vardy, E, LaFerla, FM, Jöckel, KH, Lah, JJ, Dichgans, M, Leverenz, JB, Mann, D, Levey, AI, Pickering-Brown, S, Lieberman, AP, Klopp, N, Lunetta, KL, Wichmann, HE, Lyketsos, CG, Morgan, K, Marson, DC, Brown, K, Martiniuk, F, Medway, C, Mash, DC, Nöthen, MM, Masliah, E, Hooper, NM, McCormick, WC, Daniele, A, McCurry, SM, Bayer, A, McDavid, AN, Gallacher, J, McKee, AC, van den Bussche, H, Mesulam, M, Brayne, C, Miller, BL, Riedel-Heller, S, Miller, CA, Miller, JW, Al-Chalabi, A, Morris, JC, Shaw, CE, Myers, AJ, Wiltfang, J, O’Bryant, S, Coto, E, Olichney, JM, Alvarez, V, Parisi, JE, Singleton, AB, Paulson, HL, Collinge, J, Perry, W, Mead, S, Peskind, E, Rosser, M, Pierce, A, Ryan, N, Poon, WW, Nacmias, B, Potter, H, Sorbi, S, Quinn, JF, Sacchinelli, E, Raj, A, Spalletta, G, Raskind, M, Bossù, P, Reisberg, B, Clarke, R, Reitz, C, Smith, AD, Ringman, JM, Warden, D, Roberson, ED, Wilcock, G, Rogaeva, E, Bruni, AC, Rosen, HJ, Gallo, M, Rosenberg, RN, Ben-Shlomo, Y, Sager, MA, Mecocci, P, Saykin, AJ, Pastor, P, Cuccaro, ML, Vance, JM, Schneider, JA, Schneider, LS, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tanzi, RE, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, CE, Yu, L, Crane, PK, Bennett, DA, Boccardi, V, De Jager, PL, Warner, N, Lopez, OL, McDonough, S, Ingelsson, M, Deloukas, P, Cruchaga, C, Graff, C, Gwilliam, R, Fornage, M, Goate, AM, Sanchez-Juan, P, Kehoe, PG, Amin, N, Ertekin-Taner, N, Berr, C, Debette, S, Love, S, Launer, LJ, Younkin, SG, Dartigues, JF, Corcoran, C, Ikram, MA, Dickson, DW, Campion, D, Tschanz, J, Schmidt, H, Hakonarson, H, Munger, R, Schmidt, R, Farrer, LA, Van Broeckhoven, C, O’Donovan, MC, DeStefano, AL, Jones, L, Haines, JL, Deleuze, JF, Owen, MJ, Gudnason, V, Mayeux, R, Escott-Price, V, Psaty, BM, Ruiz, A, Ramirez, A, Wang, LS, van Duijn, CM, Holmans, PA, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Lambert, JC, Pericak-Vance, MA, Bis, JC [0000-0002-3409-1110], Garnier, JG [0000-0003-4991-763X], Smith, AV [0000-0001-9088-234X], Denning, N [0000-0001-8467-7382], Vandenberghe, R [0000-0001-6237-2502], Himali, JJ [0000-0003-1391-9481], Rodriguez-Rodriguez, E [0000-0001-7742-677X], Frisardi, V [0000-0003-0764-7387], Ortega-Cubero, S [0000-0003-0520-9439], Hanon, O [0000-0002-4697-122X], Brice, A [0000-0002-0941-3990], Albin, RL [0000-0002-0629-608X], Buxbaum, JD [0000-0001-8898-8313], Bass, NJ [0000-0002-4481-778X], Fisher, E [0000-0003-2850-9936], Bayer, A [0000-0002-7514-248X], Gallacher, J [0000-0002-2394-5299], Brayne, C [0000-0001-5307-663X], Riedel-Heller, S [0000-0003-4321-6090], Al-Chalabi, A [0000-0002-4924-7712], and Apollo - University of Cambridge Repository
- Subjects
Aging ,4202 Epidemiology ,Genome-wide association study ,Disease ,Neurodegenerative ,Biology ,3101 Biochemistry and Cell Biology ,Alzheimer's Disease ,3105 Genetics ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Acquired Cognitive Impairment ,Genetics ,medicine ,2.1 Biological and endogenous factors ,Dementia ,Gene ,030304 developmental biology ,Genetic association ,2 Aetiology ,0303 health sciences ,Prevention ,Human Genome ,42 Health Sciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Lipid metabolism ,medicine.disease ,Brain Disorders ,3. Good health ,Meta-analysis ,Neurological ,Alzheimer's disease ,030217 neurology & neurosurgery ,31 Biological Sciences - Abstract
IntroductionLate-onset Alzheimer’s disease (LOAD, onset age > 60 years) is the most prevalent dementia in the elderly1, and risk is partially driven by genetics2. Many of the loci responsible for this genetic risk were identified by genome-wide association studies (GWAS)3–8. To identify additional LOAD risk loci, the we performed the largest GWAS to date (89,769 individuals), analyzing both common and rare variants. We confirm 20 previous LOAD risk loci and identify four new genome-wide loci (IQCK, ACE, ADAM10, and ADAMTS1). Pathway analysis of these data implicates the immune system and lipid metabolism, and for the first time tau binding proteins and APP metabolism. These findings show that genetic variants affecting APP and Aβ processing are not only associated with early-onset autosomal dominant AD but also with LOAD. Analysis of AD risk genes and pathways show enrichment for rare variants (P = 1.32 × 10−7) indicating that additional rare variants remain to be identified.
- Published
- 2018
- Full Text
- View/download PDF
16. COMPREENSÃO DE SEXUALIDADE POR HOMENS IDOSOS DE ÁREA RURAL
- Author
-
Cabral, Nidiane Evans Da Silva, primary, Pereira, Gleideson Cerqueira dos Santos, additional, Souza, Uilma Santos de, additional, Lima, Claudia Feio da Maia, additional, Santana, George Mariane Soares, additional, and Castañeda, Raúl Fernando Guerrero, additional
- Published
- 2019
- Full Text
- View/download PDF
17. Understanding sexuality by rural elderly women
- Author
-
Cabral, Nidiane Evans da Silva, primary, Lima, Claudia Feio da Maia, additional, Rivemales, Maria da Conceição Costa, additional, Souza, Uilma Santos de, additional, and Silva, Bárbara Martins Corrêa da, additional
- Published
- 2019
- Full Text
- View/download PDF
18. AUTOAVALIAÇÃO DA CONDIÇÃO DE SAÚDE DA POPULAÇÃO BAIANA
- Author
-
Roberta Borges Silva, Simone Seixas da Cruz, Edla Carvalho Lima Porto, Julita Maria Freitas Coelho, Dulcineia Santana dos Santos, Géssica Santana Orrico, Ana Claudia Morais Godoy Figueiredo, Nidiane Evans da Silva Cabral, Josicélia Estrela Tuy Batista, Maria Luiza Camurugi Macedo, Daniel Ferreira Cunha, and Isaac Suzart Gomes-Filho
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Abstract
Objetivo: Descrever a autoavaliação da condição de saúde da população baiana, de acordo com alguns fatores sociodemográficos. Método: Estudo de caráter transversal, cujo banco de dados utilizado foi da Pesquisa Nacional de Saúde (PNS). Foram levantados dados de 6153 pessoas, de ambos os sexos, com faixa etária acima de 18 anos, residentes na Bahia. As variáveis selecionadas foram sexo, raça/cor, estado civil, plano de saúde, diagnóstico de doença crônica, presença de depressão nas últimas semanas, nível de instrução, faixa etária e condição de saúde. Aplicou-se o teste qui-quadrado na análise dos dados, por meio do pacote estatístico Stata 15. Resultados: Definiram seu estado de saúde como bom: 56,88% dos homens, 68,87% dos indivíduos com faixa etária entre 18 e 29 anos, união estável/livre (56,24%), com plano de saúde (58,27%), ensino médio incompleto (73,66%). Em contrapartida, a maior parte das pessoas deprimidas a mais de uma semana (59,44%) e aquelas com doenças crônicas (54,48%) classificaram seu estado de saúde como regular. Conclusão: A maioria das pessoas relatou seu estado de saúde como bom. Destaca-se que essa definição foi mais frequente em pessoas do sexo masculino, jovens, com companheiro, que possuem plano de saúde e maior escolaridade.
- Published
- 2017
19. Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat
- Author
-
Drakakis, G, Wafford, KA, Brewerton, SC, Bodkin, MJ, Evans, DA, Bender, A, Drakakis, Georgios [0000-0002-6635-9273], Bender, Andreas [0000-0002-6683-7546], and Apollo - University of Cambridge Repository
- Subjects
Biomedical Research ,Polypharmacology ,Imidazoles ,Animals ,Hypnotics and Sedatives ,Computer Simulation ,Benzazepines ,Rats - Abstract
In this work, we describe the computational ("in silico") mode-of-action analysis of CNS-active drugs, which is taking both multiple simultaneous hypotheses as well as sets of protein targets for each mode-of-action into account, and which was followed by successful prospective in vitro and in vivo validation. Using sleep-related phenotypic readouts describing both efficacy and side effects for 491 compounds tested in rat, we defined an "optimal" (desirable) sleeping pattern. Compounds were subjected to in silico target prediction (which was experimentally confirmed for 21 out of 28 cases), followed by the utilization of decision trees for deriving polypharmacological bioactivity profiles. We demonstrated that predicted bioactivities improved classification performance compared to using only structural information. Moreover, DrugBank molecules were processed via the same pipeline, and compounds in many cases not annotated as sedative-hypnotic (alcaftadine, benzatropine, palonosetron, ecopipam, cyproheptadine, sertindole, and clopenthixol) were prospectively validated in vivo. Alcaftadine, ecopipam cyproheptadine, and clopenthixol were found to promote sleep as predicted, benzatropine showed only a small increase in NREM sleep, whereas sertindole promoted wakefulness. To our knowledge, the sedative-hypnotic effects of alcaftadine and ecopipam have not been previously discussed in the literature. The method described extends previous single-target, single-mode-of-action models and is applicable across disease areas.
- Published
- 2017
- Full Text
- View/download PDF
20. AUTOAVALIAÇÃO DA CONDIÇÃO DE SAÚDE DA POPULAÇÃO BAIANA
- Author
-
Godoy Figueiredo, Ana Claudia Morais, primary, Camurugi Macedo, Maria Luiza, additional, Ferreira Cunha, Daniel, additional, Santana dos Santos, Dulcineia, additional, Evans da Silva Cabral, Nidiane, additional, Suzart Gomes-Filho, Isaac, additional, Tuy Batista, Josicélia Estrela, additional, Santana Orrico, Géssica, additional, Carvalho Lima Porto, Edla, additional, Freitas Coelho, Julita Maria, additional, Borges Silva, Roberta, additional, and Seixas da Cruz, Simone, additional
- Published
- 2017
- Full Text
- View/download PDF
21. In Situ Patterning of Ultrasharp Dopant Profiles in Silicon
- Author
-
Cooil, SP, Mazzola, F, Klemm, HW, Peschel, G, Niu, YR, Zakharov, AA, Simmons, MY, Schmidt, T, Evans, DA, Miwa, JA, Wells, JW, Cooil, SP, Mazzola, F, Klemm, HW, Peschel, G, Niu, YR, Zakharov, AA, Simmons, MY, Schmidt, T, Evans, DA, Miwa, JA, and Wells, JW
- Abstract
We develop a method for patterning a buried two-dimensional electron gas (2DEG) in silicon using low kinetic energy electron stimulated desorption (LEESD) of a monohydride resist mask. A buried 2DEG forms as a result of placing a dense and narrow profile of phosphorus dopants beneath the silicon surface; a so-called δ -layer. Such 2D dopant profiles have previously been studied theoretically, and by angle-resolved photoemission spectroscopy, and have been shown to host a 2DEG with properties desirable for atomic-scale devices and quantum computation applications. Here we outline a patterning method based on low kinetic energy electron beam lithography, combined with in situ characterization, and demonstrate the formation of patterned features with dopant concentrations sufficient to create localized 2DEG states.
- Published
- 2017
22. Correction: The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151
- Author
-
Ben-Avraham, D, Karasik, D, Verghese, J, Lunetta, KL, Smith, JA, Eicher, JD, Vered, R, Deelen, J, Arnold, AM, Buchman, AS, Tanaka, T, Faul, JD, Nethander, M, Fornage, M, Adams, HH, Matteini, AM, Callisaya, ML, Smith, AV, Yu, L, De Jager, PL, Evans, DA, Gudnason, V, Hofman, A, Pattie, A, Corley, J, Launer, LJ, Knopman, DS, Parimi, N, Turner, ST, Bandinelli, S, Beekman, M, Gutman, D, Sharvit, L, Mooijaart, SP, Liewald, DC, Houwing-Duistermaat, JJ, Ohlsson, C, Moed, M, Verlinden, VJ, Mellström, D, van der Geest, JN, Karlsson, M, Hernandez, D, McWhirter, Rebekah, Liu, Y, Thomson, R, Tranah, GJ, Uitterlinden, AG, Weir, DR, Zhao, W, Starr, JM, Johnson, AD, Arfan Ikram, M, Bennett, DA, Cummings, SR, Deary, IJ, Harris, TB, Kardia, SLR, Mosley, TH, Srikanth, VK, Windham, BG, Newman, AB, Walston, JD, Davies, G, Evans, DS, Slagboom, EP, Ferrucci, L, Kiel, DP, Murabito, JM, Atzmon, G, Ben-Avraham, D, Karasik, D, Verghese, J, Lunetta, KL, Smith, JA, Eicher, JD, Vered, R, Deelen, J, Arnold, AM, Buchman, AS, Tanaka, T, Faul, JD, Nethander, M, Fornage, M, Adams, HH, Matteini, AM, Callisaya, ML, Smith, AV, Yu, L, De Jager, PL, Evans, DA, Gudnason, V, Hofman, A, Pattie, A, Corley, J, Launer, LJ, Knopman, DS, Parimi, N, Turner, ST, Bandinelli, S, Beekman, M, Gutman, D, Sharvit, L, Mooijaart, SP, Liewald, DC, Houwing-Duistermaat, JJ, Ohlsson, C, Moed, M, Verlinden, VJ, Mellström, D, van der Geest, JN, Karlsson, M, Hernandez, D, McWhirter, Rebekah, Liu, Y, Thomson, R, Tranah, GJ, Uitterlinden, AG, Weir, DR, Zhao, W, Starr, JM, Johnson, AD, Arfan Ikram, M, Bennett, DA, Cummings, SR, Deary, IJ, Harris, TB, Kardia, SLR, Mosley, TH, Srikanth, VK, Windham, BG, Newman, AB, Walston, JD, Davies, G, Evans, DS, Slagboom, EP, Ferrucci, L, Kiel, DP, Murabito, JM, and Atzmon, G
- Published
- 2017
23. The complex genetics of gait speed: Genome-wide meta-analysis approach
- Author
-
Ben-Avraham, D, Karasik, D, Verghese, J, Lunetta, KL, Smith, JA, Eicher, JD, Vered, R, Deelen, J, Arnold, AM, Buchman, AS, Tanaka, T, Faul, JD, Nethander, M, Fornage, M, Adams, HH, Matteini, AM, Callisaya, ML, Smith, AV, Yu, L, De Jager, PL, Evans, DA, Gudnason, V, Hofman, A, Pattie, A, Corley, J, Launer, LJ, Knopman, DS, Parimi, N, Turner, ST, Bandinelli, S, Beekman, M, Gutman, D, Sharvit, L, Mooijaart, SP, Liewald, DC, Houwing-Duistermaat, JJ, Ohlsson, C, Moed, M, Verlinden, VJ, Mellström, D, van der Geest, JN, Karlsson, M, Hernandez, D, McWhirter, Rebekah, Liu, Y, Thomson, R, Tranah, GJ, Uitterlinden, AG, Weir, DR, Zhao, W, Starr, JM, Johnson, AD, Arfan Ikram, M, Bennett, DA, Cummings, SR, Deary, IJ, Harris, TB, Sharon, SL, Mosley, TH, Srikanth, VK, Windham, BG, Newman, AB, Walston, JD, Davies, G, Evans, DS, Slagboom, EP, Ferrucci, L, Kiel, DP, Murabito, JM, Atzmon, G, Ben-Avraham, D, Karasik, D, Verghese, J, Lunetta, KL, Smith, JA, Eicher, JD, Vered, R, Deelen, J, Arnold, AM, Buchman, AS, Tanaka, T, Faul, JD, Nethander, M, Fornage, M, Adams, HH, Matteini, AM, Callisaya, ML, Smith, AV, Yu, L, De Jager, PL, Evans, DA, Gudnason, V, Hofman, A, Pattie, A, Corley, J, Launer, LJ, Knopman, DS, Parimi, N, Turner, ST, Bandinelli, S, Beekman, M, Gutman, D, Sharvit, L, Mooijaart, SP, Liewald, DC, Houwing-Duistermaat, JJ, Ohlsson, C, Moed, M, Verlinden, VJ, Mellström, D, van der Geest, JN, Karlsson, M, Hernandez, D, McWhirter, Rebekah, Liu, Y, Thomson, R, Tranah, GJ, Uitterlinden, AG, Weir, DR, Zhao, W, Starr, JM, Johnson, AD, Arfan Ikram, M, Bennett, DA, Cummings, SR, Deary, IJ, Harris, TB, Sharon, SL, Mosley, TH, Srikanth, VK, Windham, BG, Newman, AB, Walston, JD, Davies, G, Evans, DS, Slagboom, EP, Ferrucci, L, Kiel, DP, Murabito, JM, and Atzmon, G
- Published
- 2017
24. Interaction of Electro-medical and Communication Technologies in Hospitals
- Author
-
Bicentennial Electrical Engineering Congress (1988 : Melbourne, Vic.), Evans, DA, and Kemp, RSG
- Published
- 1988
25. Estimation of Groundwater Recharge Using Kalman Filter Method
- Author
-
Hydrology and Water Resources Symposium (15th : 1983 : Hobart, Tas.), Viswanathan, MN, and Evans, DA
- Published
- 1983
26. Glycated hemoglobin measurement and prediction of cardiovascular disease
- Author
-
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez de la Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J. Collaborators Simpson LM, Coresh J, Wagenknecht L, Shaw JE, Zimmet PZ, Magliano D, Wannamethee SG, Morris RW, Kiechl S, Santer P, Bonora E, Casas JP, Ebrahim S, Ben Shlomo Y, Yarnell JW, Elwood P, Bachman DL, Nietert PJ, Håheim LL, Søgaard AJ, Tybjaerg Hansen A, Frikke Schmidt R, Benn M, Palmieri L, Vanuzzo D, Bonnet F, Copin N, Roussel R, Gómez Gerique JA, Rubio Herrera MA, Gutiérrez Fuentes JA, Friedlander Y, McCallum J, Simons J, Lee AJ, McLachlan S, Taylor JO, Guralnik JM, Phillips CL, Evans DA, Kohout F, Cohen H, George L, Fillenbaum G, McGloin JM, Khaw K., Schöttker B, Müller H, Rothenbacher D, Jansson J., Hallmans G, Tuomilehto J, Donfrancesco C, Woodward M, Oizumi T, Kayama T, Kato T, Danker R, Chetrit A, Wilhelmsen L, Eriksson H, Lappas G, Bengtsson C, Lissner L, Skoog I, Cremer P, Arima H, Ninomiya T, Hata J, Nijpels G, Stehouwer CD, Tuomainen T., Voutilainen S, Kurl S, de Boer IH, Bertoni AG, Veschuren WM, Dullaart RP, Lambers Heerspink HJ, Hilege HL, Trompet S, Stott DJ, Dagenais GR, Cantin B, Dehghan D, Hofman A, Franco OH, Tunstall Pedoe H, Lee E, Best L, Howard BV, Can G, Ademoğlu E, Sakurai M, Nakamura K, Morikawa Y, Løchen M., Mathiesen EB, Wilsgaard T, Byberg L, Cederholm T, Olsson E, Pradhan AD, Cook NR, Kromhout D, Walker M, Watson S, Burgess S, Gregson J, Harshfield E, Pennells L, Spackman S, Warnakula S, Wood AM, Danesh J., PANICO, SALVATORE, Emerging Risk Factors, Collaboration, Di Angelantonio, E, Gao, P, Khan, H, Butterworth, A, Wormser, D, Kaptoge, S, Kondapally Seshasai, Sr, Thompson, A, Sarwar, N, Willeit, P, Ridker, Pm, Barr, El, Khaw, Kt, Psaty, Bm, Brenner, H, Balkau, B, Dekker, Jm, Lawlor, Da, Daimon, M, Willeit, J, Njølstad, I, Nissinen, A, Brunner, Ej, Kuller, Lh, Price, Jf, Sundström, J, Knuiman, Mw, Feskens, Ej, Verschuren, Wm, Wald, N, Bakker, Sj, Whincup, Ph, Ford, I, Goldbourt, U, Gómez de la Cámara, A, Gallacher, J, Simons, La, Rosengren, A, Sutherland, Se, Björkelund, C, Blazer, Dg, Wassertheil Smoller, S, Onat, A, Marín Ibañez, A, Casiglia, E, Jukema, Jw, Simpson, Lm, Giampaoli, S, Nordestgaard, Bg, Selmer, R, Wennberg, P, Kauhanen, J, Salonen, Jt, Dankner, R, Barrett Connor, E, Kavousi, M, Gudnason, V, Evans, D, Wallace, Rb, Cushman, M, D'Agostino RB, Sr, Umans, Jg, Kiyohara, Y, Nakagawa, H, Sato, S, Gillum, Rf, Folsom, Ar, van der Schouw, Yt, Moons, Kg, Griffin, Sj, Sattar, N, Wareham, Nj, Selvin, E, Thompson, Sg, Danesh J., Collaborators Simpson LM, Coresh, J, Wagenknecht, L, Shaw, Je, Zimmet, Pz, Magliano, D, Wannamethee, Sg, Morris, Rw, Kiechl, S, Santer, P, Bonora, E, Casas, Jp, Ebrahim, S, Ben Shlomo, Y, Yarnell, Jw, Elwood, P, Bachman, Dl, Nietert, Pj, Håheim, Ll, Søgaard, Aj, Tybjaerg Hansen, A, Frikke Schmidt, R, Benn, M, Palmieri, L, Vanuzzo, D, Panico, Salvatore, Bonnet, F, Copin, N, Roussel, R, Gómez Gerique, Ja, Rubio Herrera, Ma, Gutiérrez Fuentes, Ja, Friedlander, Y, Mccallum, J, Simons, J, Lee, Aj, Mclachlan, S, Taylor, Jo, Guralnik, Jm, Phillips, Cl, Evans, Da, Kohout, F, Cohen, H, George, L, Fillenbaum, G, Mcgloin, Jm, Khaw, K., Schöttker, B, Müller, H, Rothenbacher, D, Jansson, J., Hallmans, G, Tuomilehto, J, Donfrancesco, C, Woodward, M, Oizumi, T, Kayama, T, Kato, T, Danker, R, Chetrit, A, Wilhelmsen, L, Eriksson, H, Lappas, G, Bengtsson, C, Lissner, L, Skoog, I, Cremer, P, Arima, H, Ninomiya, T, Hata, J, Nijpels, G, Stehouwer, Cd, Tuomainen, T., Voutilainen, S, Kurl, S, de Boer, Ih, Bertoni, Ag, Veschuren, Wm, Dullaart, Rp, Lambers Heerspink, Hj, Hilege, Hl, Trompet, S, Stott, Dj, Dagenais, Gr, Cantin, B, Dehghan, D, Hofman, A, Franco, Oh, Tunstall Pedoe, H, Lee, E, Best, L, Howard, Bv, Can, G, Ademoğlu, E, Sakurai, M, Nakamura, K, Morikawa, Y, Løchen, M., Mathiesen, Eb, Wilsgaard, T, Byberg, L, Cederholm, T, Olsson, E, Pradhan, Ad, Cook, Nr, Kromhout, D, Walker, M, Watson, S, Burgess, S, Gregson, J, Harshfield, E, Pennells, L, Spackman, S, Warnakula, S, Wood, Am, and Danesh, J.
- Published
- 2014
27. Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
- Author
-
Verhaaren, BFJ, Debette, S, Bis, JC, Smith, JA, Ikram, MK, Adams, HH, Beecham, AH, Rajan, KB, Lopez, LM, Barral, S, Van Buchem, MA, Van Der Grond, J, Smith, AV, Hegenscheid, K, Aggarwal, NT, De Andrade, M, Atkinson, EJ, Beekman, M, Beiser, AS, Blanton, SH, Boerwinkle, E, Brickman, AM, Bryan, RN, Chauhan, G, Chen, CPLH, Chouraki, V, De Craen, AJM, Crivello, F, Deary, IJ, Deelen, J, De Jager, PL, Dufouil, C, Elkind, MSV, Evans, DA, Freudenberger, P, Gottesman, RF, Gunason, V, Habes, M, Heckbert, SR, Heiss, G, Hilal, S, Hofer, E, Hofman, A, Ibrahim-Verbaas, CA, Knopman, DS, Lewis, CE, Liao, J, Liewald, DCM, Luciano, M, Van Der Lugt, A, Martinez, OO, Mayeux, R, Mazoyer, B, Nalls, M, Nauck, M, Niessen, WJ, Oostra, BA, Psaty, BM, Rice, KM, Rotter, JI, Von Sarnowski, B, Schmidt, H, Schreiner, PJ, Schuur, M, Sidney, SS, Sigurdsson, S, Slagboom, PE, Stott, DJM, Van Swieten, JC, Teumer, A, Töglhofer, AM, Traylor, M, Trompet, S, Turner, ST, Tzourio, C, Uh, HW, Uitterlinden, AG, Vernooij, MW, Wang, JJ, Wong, TY, Wardlaw, JM, Windham, BG, Wittfeld, K, Wolf, C, Wright, CB, Yang, Q, Zhao, W, Zijdenbos, A, Jukema, JW, Sacco, RL, Kardia, SLR, Amouyel, P, Mosley, TH, Longstreth, WT, DeCarli, CC, Van Duijn, CM, Schmidt, R, Launer, LJ, and Grabe, HJ
- Subjects
genome-wide association study ,hypertension ,leukoencephalopathies ,polymorphisms, single nucleotide ,cerebrovascular disorders ,cerebral small vessel diseases - Abstract
© 2015 American Heart Association, Inc. Background-The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies. Methods and Results-We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (n=17 936), African (n=1943), Hispanic (n=795), and Asian (n=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each single-nucleotide polymorphism and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (P=2.7×10-19) and identified novel loci on chr10q24 (P=1.6×10-9) and chr2p21 (P=4.4×10-8). In the multiethnic meta-analysis, we identified 2 additional loci, on chr1q22 (P=2.0×10-8) and chr2p16 (P=1.5×10-8). The novel loci contained genes that have been implicated in Alzheimer disease (chr2p21 and chr10q24), intracerebral hemorrhage (chr1q22), neuroinflammatory diseases (chr2p21), and glioma (chr10q24 and chr2p16). Conclusions-We identified 4 novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of WMH in addition to previously proposed ischemic mechanisms.
- Published
- 2015
28. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium
- Author
-
Matteini, A M, Tanaka, T, Karasik, D, Atzmon, G, Chou, WC, Eicher, JD, Johnson, AD, Arnold, AM, Callisaya, ML, Davies, G, Evans, DS, Holtfreter, B, Lohman, K, Lunetta, KL, Mangino, M, Smith, AV, Smith, JA, Teumer, A, Yu, L, Arking, DE, Buchman, AS, Chibinik, L B, De Jager, PL, Evans, DA, Faul, JD, Garcia, ME, Gillham-Nasenya, I, Gudnason, V, Hofman, Bert, Hsu, YH, Ittermann, T, Lahousse, Lies, Liewald, DC, Liu, YM, Lopez, L, Rivadeneira, Fernando, Rotter, JI, Siggeirsdottir, K, Starr, JM, Thomson, R, Tranah, GJ, Uitterlinden, André, Volker, U, Volzke, H, Weir, DR, Yaffe, K, Zhao, W, Zhuang, WV, Zmuda, JM, Bennett, DA, Cummings, SR, Deary, IJ, Ferrucci, L, Harris, TB, Kardia, SLR, Kocher, T, Kritchevsky, SB, Psaty, BM, Seshadri, S, Spector, TD, Srikanth, V K, Windham, BG, Zillikens, M.C., Newman, AB, Walston, JD, Kiel, DP, Murabito, JM, Matteini, A M, Tanaka, T, Karasik, D, Atzmon, G, Chou, WC, Eicher, JD, Johnson, AD, Arnold, AM, Callisaya, ML, Davies, G, Evans, DS, Holtfreter, B, Lohman, K, Lunetta, KL, Mangino, M, Smith, AV, Smith, JA, Teumer, A, Yu, L, Arking, DE, Buchman, AS, Chibinik, L B, De Jager, PL, Evans, DA, Faul, JD, Garcia, ME, Gillham-Nasenya, I, Gudnason, V, Hofman, Bert, Hsu, YH, Ittermann, T, Lahousse, Lies, Liewald, DC, Liu, YM, Lopez, L, Rivadeneira, Fernando, Rotter, JI, Siggeirsdottir, K, Starr, JM, Thomson, R, Tranah, GJ, Uitterlinden, André, Volker, U, Volzke, H, Weir, DR, Yaffe, K, Zhao, W, Zhuang, WV, Zmuda, JM, Bennett, DA, Cummings, SR, Deary, IJ, Ferrucci, L, Harris, TB, Kardia, SLR, Kocher, T, Kritchevsky, SB, Psaty, BM, Seshadri, S, Spector, TD, Srikanth, V K, Windham, BG, Zillikens, M.C., Newman, AB, Walston, JD, Kiel, DP, and Murabito, JM
- Published
- 2016
29. High-resolution X-ray spectroscopy and imaging of Mrk 573 RID B-4804-2010
- Author
-
Bianchi S, Chiaberge M, Evans DA, Guainazzi M, Baldi RD, MATT, Giorgio, Piconcelli E., BIANCHI, STEFANO, Bianchi, S, Chiaberge, M, Evans, Da, Guainazzi, M, Baldi, Rd, Matt, Giorgio, Piconcelli, E., and Bianchi, Stefano
- Subjects
Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
We present a detailed analysis of the XMM-Newton Reflection Grating Spectrometer (RGS) high-resolution X-ray spectra of the Seyfert 2 galaxy, Mrk 573. This analysis is complemented by the study of the Chandra image and its comparison to optical (Hubble Space Telescope) and radio (Very Large Array) data. The soft X-ray emission is mainly due to gas photoionized by the central active galactic nucleus, as indicated by the detection of radiative recombination continua from O vii and O viii as well as by the prominence of the O vii forbidden line. This result is confirmed by the best fit obtained with a self-consistent cloudy photoionization model. However, a collisionally excited component is also required, in order to reproduce the Fe xvii lines, accounting for about one-third of the total luminosity in the 15-26 A band. Once the same model in the Chandra Advanced CCD Imaging Spectrometer (ACIS) data is adopted, another photoionized component, with a higher ionization parameter, is needed to take into account emission from higher Z metals. The broad-band ACIS spectrum also confirms the Compton-thick nature of the source. The imaging analysis shows the close morphological correspondence between the soft X-ray and the [O iii] emission. The radio emission appears much more compact, although clearly aligned with the narrow-line region. The collisional phase of the soft X-ray emission may be due to starburst, requiring a star formation rate of similar or equal to 5-9 M(circle dot) yr-1, but there is no clear evidence of this kind of activity from other wavelengths. On the other hand, it may be related to the radio ejecta, responsible for the heating of the plasma interacting with the outflow, but the estimated pressure of the hot gas is much larger than the pressure of the radio jets, assuming equipartition and under reasonable physical parameters.
- Published
- 2010
30. Cash crops and food security: evidence from smallholder cocoa and cashew farmers in Ghana
- Author
-
Ishmael Hashmiu, Olivia Agbenyega, and Evans Dawoe
- Subjects
Cash crops ,Food security ,Income ,Land access ,Crop diversification ,Forest-Savannah Transition Zone ,Agriculture ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Background Food security is a major development concern worldwide. The use of arable lands to grow cash crops raises additional concerns, yet empirical evidence on the relationship between cash cropping and food security remains inconclusive. Using survey data from 408 randomly sampled households, this paper assesses the income and food security implications of reviving cocoa farming in the Forest-Savannah Transition Zone of Ghana. In addition, the paper examines the influence of socioeconomic factors and diversification into cashew on the food security of cocoa households. Data was collected from 12 rural communities, where food crop production was the main source of livelihood. A causal-comparative design was used. Food security was measured using the USDA Food Security Core Module. Results Contrary to the literature that cash crops undermine food security, findings indicate a positive relationship between cocoa farming, household crop income and food security, highlighting complementarities between cocoa, food crop and cashew production. Although income from cocoa alone was not sufficient enough to guarantee food security, it enhanced the financial ability of farmers to diversify into cashew and expand food crop production. This minimised market dependency for food staples, enhanced annual crop income, and ensured a continuous flow of income. Overall, the food security advantage of cocoa farming was predicted by diversification into cashew, displacement of food crops using cocoa, socioeconomic factors, such as land ownership, livestock ownership, and formal education; and marginally by total annual crop income. Conclusions Income from cocoa alone is not high enough and widely distributed to guarantee food security. Reinvesting the returns from cocoa in cashew and food crops seems to be a more reliable pathway to enhancing food security than merely depending on the income to buy food. A semi-subsistence system that ensures optimum combination of cash and food crops is, therefore, recommended, but this may require sufficient access to land.
- Published
- 2022
- Full Text
- View/download PDF
31. Impact of COVID-19 pandemic on Tuberculosis and HIV services in Ghana: An interrupted time series analysis.
- Author
-
Eric Osei, Hubert Amu, Gideon Kye-Duodu, Mavis Pearl Kwabla, Evans Danso, Fred N Binka, and So Yoon Kim
- Subjects
Medicine ,Science - Abstract
IntroductionThe Coronavirus disease 2019 (COVID-19) burden, coupled with unprecedented control measures including physical distancing, travel bans, and lockdowns of cities, implemented to stop the spread of the virus, have undoubtedly far-reaching aftereffects on other diseases. In low and middle-income countries (LMICs), a particular worry is the potential impact on Human Immunodeficiency Virus (HIV) and Tuberculosis (TB), as a consequence of possible disruption to health services and limiting access to needed life-saving health care. In Ghana, there is a paucity of information regarding the impact of COVID-19 on disease control, particularly TB and HIV control. This study sought to contribute to bridging this knowledge gap.MethodThe study involved the analysis of secondary data obtained from the District Health Information Management System-2 (DHIMS-2) database of Ghana Health Service, from 2016 to 2020. Data were analysed using an interrupted time-series regression approach to estimate the impact of COVID-19 on TB case notification, HIV testing, and Antiretroviral Therapy (ART) initiations, using March 2020 as the event period.ResultsThe study showed that during the COVID-19 pandemic period, there was an abrupt decline of 20.5% (955CI: 16.0%, 24.5%) in TB case notifications in April and 32.7% (95%CI: 28.8%, 39.1%) in May 2020, with a median monthly decline of 21.4% from April-December 2020. A cumulative loss of 2,128 (20%; 95%CI: 13.3%, 26.7%) TB cases was observed nationwide as of December 2020. There was also a 40.3% decrease in people presenting for HIV tests in the first month of COVID-19 (April 2020) and a cumulative loss of 262620 (26.5%) HIV tests as of December 2020 attributable to the COVID-19 pandemic. ART initiations increased by 39.2% in the first month and thereafter decreased by an average of 10% per month from May to September 2020. Cumulatively, 443 (1.9%) more of the people living with HIV initiated ART during the pandemic period, however, this was not statistically significant.ConclusionThis study demonstrated that the COVID-19 pandemic negatively impacted TB case notifications and HIV testing and counselling services, However, ART initiation was generally not impacted during the first year of the pandemic. Proactive approaches aimed at actively finding the thousands of individuals with TB who were missed in 2020 and increasing HIV testing and counselling and subsequent treatment initiations should be prioritised.
- Published
- 2023
- Full Text
- View/download PDF
32. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Author
-
Winkler, TW, Justice, AE, Graff, M, Barata, L, Feitosa, MF, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpelainen, TO, Lu, YC, Magi, R, Mihailov, E, Pers, TH, Rueger, S, Teumer, A, Ehret, GB, Ferreira, T, Heard-Costa, NL, Karjalainen, J, Lagou, V, Mahajan, A, Neinast, MD, Prokopenko, I, Simino, J, Teslovich, TM, Jansen, R, Westra, HJ, White, CC, Absher, D, Ahluwalia, TS, Ahmad, Shahzad, Albrecht, E, Alves, AC, Bragg-Gresham, JL, de Craen, AJM, Bis, JC, Bonnefond, A, Boucher, G, Cadby, G, Cheng, YC, Chiang, CWK, Delgado, G, Demirkan, Ayse, Dueker, N, Eklund, N, Eiriksdottir, G, Eriksson, J, Feenstra, B, Fischer, K (Kirsten), Frau, F, Galesloot, TE, Geller, F, Goel, A, Gorski, M, Grammer, TB, Gustafsson, S, Haitjema, S, Hottenga, JJ (Jouke Jan), Huffman, JE, Jackson, AU, Jacobs, KB, Johansson, A, Kaakinen, M, Kleber, ME, Lahti, J, Leach, IM, Lehne, B, Liu, YF, Lo, KS, Lorentzon, M, Luan, J, Madden, PAF, Mangino, M, McKnight, B, Medina Gomez, Maria, Monda, KL, Montasser, ME, Muller, G, Muller-Nurasyid, M, Nolte, IM (Ilja), Panoutsopoulou, K, Pascoe, L, Paternoster, L, Rayner, NW, Renstrom, F, Rizzi, F, Rose, LM, Ryan, KA, Salo, P, Sanna, S, Scharnagl, H, Shi, JX, Smith, AV, Southam, L, Stancakova, A, Steinthorsdottir, V, Strawbridge, RJ, Sung, YJ, Tachmazidou, I, Tanaka, T, Thorleifsson, G, Trompet, S, Pervjakova, N, Tyrer, JP, Vandenput, L, Laan, Sander, van der Velde, Nathalie, van Setten, J, van Vliet-Ostaptchouk, JV, Verweij, N (Niek), Vlachopoulou, E, Waite, LL, Wang, SR, Wang, ZM, Wild, SH, Willenborg, C, Wilson, JF, Wong, A, Yang, Jiaqi, Yengo, L, Yerges-Armstrong, LM, Yu, L, Zhang, WH, Zhao, JH, Andersson, EA, Bakker, SJL, Baldassarre, D, Banasik, K, Barcella, M, Barlassina, C, Bellis, C, Benaglio, P, Blangero, J, Bluher, M, Bonnet, F, Bonnycastle, LL, Boyd, HA, Bruinenberg, M, Buchman, AS, Campbell, H, Chen, YDI, Chines, PS, Claudi-Boehm, S, Cole, J, Collins, FS, de Geus, EJC, de Groot, LCPGM (Lisette), Dimitriou, M, Duan, J, Enroth, S, Eury, E, Farmaki, AE, Forouhi, NG, Friedrich, N, Gejman, PV, Gigante, B, Glorioso, N, Go, AS, Gottesman, O, Grassler, J, Grallert, H, Grarup, N, Gu, YM, Broer, Linda, Ham, Annelies, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Heath, AC, Henders, AK, Hernandez, D, Hillege, H, Holmen, O, Hovingh, KG, Hui, J, Husemoen, LL, Hutri-Kahonen, N, Hysi, PG, Illig, T, De Jager, PL, Jalilzadeh, S, Jorgensen, T, Jukema, JW, Juonala, M, Kanoni, S, Karaleftheri, M, Khaw, KT, Kinnunen, L, Kittner, SJ, Koenig, W, Kolcic, I, Kovacs, P, Krarup, NT, Kratzer, W, Kruger, J, Kuh, D, Kumari, M, Kyriakou, T, Langenberg, C, Lannfelt, L, Lanzani, C, Lotay, V, Launer, LJ (Lenore), Leander, K, Lindstrom, J, Linneberg, A, Liu, YP, Lobbens, S, Luben, R, Lyssenko, V, Mannisto, S, Magnusson, PK, McArdle, WL, Menni, C, Merger, S, Milani, L, Montgomery, GW, Morris, AP, Narisu, N, Nelis, M, Ong, KK, Palotie, A, Perusse, L, Pichler, I, Pilia, MG, Pouta, A, Rheinberger, M, Ribel-Madsen, R, Richards, M, Rice, KM, Rice, TK, Rivolta, C, Salomaa, V, Sanders, AR, Sarzynski, MA, Scholtens, s, Scott, RA, Scott, WR, Sebert, S, Sengupta, S, Sennblad, B, Seufferlein, T, Silveira, A, Slagboom, PE (Eline), Smit, JH, Sparso, TH, Stirrups, K, Stolk, RP (Ronald), Stringham, HM, Swertz, MA, Swift, AJ, Syvanen, AC, Tan, ST, Thorand, B, Tonjes, A, Tremblay, A, Tsafantakis, E, van der Most, PJ, Volker, U, Vohl, MC, Vonk, JM, Waldenberger, M, Walker, RW, Wennauer, R, Widen, E, Willemsen, G, Wilsgaard, T, Wright, AF, Zillikens, M.C., Boon - van Dijk, Suzanne, Schoor, NM, Asselbergs, FW, de Bakker, PIW, Beckmann, JS, Beilby, J, Bennett, DA, Bergman, RN, Bergmann, S, Boger, CA, Boehm, BO, Boerwinkle, E, Boomsma, DI, Bornstein, SR, Bottinger, EP, Bouchard, C, Chambers, JC, Chanock, SJ, Chasman, DI, Cucca, F, Cusi, D, Dedoussis, G, Erdmann, J, Eriksson, JG, Evans, DA, de Faire, U, Farrall, M, Ferrucci, L, Ford, I, Franke, L, Franks, PW, Froguel, P, Gansevoort, RT, Gieger, C, Gronberg, H, Gudnason, V, Gyllensten, U, Hall, P, Hamsten, A, van der Harst, P, Hayward, C, Heliovaara, M, Hengstenberg, C, Hicks, AA, Hingorani, A, Hofman, Bert, Hu, F, Huikuri, HV, Hveem, K, James, AL, Jordan, JM, Jula, A, Kahonen, M, Kajantie, E, Kathiresan, S, Kiemeney, LALM, Kivimaki, M, Knekt, PB, Koistinen, HA, Kooner, JS, Koskinen, S, Kuusisto, J, Maerz, W, Martin, NG, Laakso, M, Lakka, TA, Lehtimaki, T, Lettre, G, Levinson, DF, Lind, L, Lokki, ML, Mantyselka, P, Melbye, M, Metspalu, A, Mitchell, BD, Moll, FL, Murray, JC, Musk, AW, Nieminen, MS, Njolstad, I, Ohlsson, C, Oldehinkel, AJ (A.), Oostra, Ben, Palmer, LJ, Pankow, JS, Pasterkamp, G, Pedersen, NL, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Psaty, BM, Qi, L, Quertermous, T, Raitakari, OT, Rankinen, T, Rauramaa, R, Ridker, PM, Rioux, JD, Rivadeneira, Fernando, Rotter, JI, Rudan, I, den Ruijter, HM, Saltevo, J, Sattar, N, Schunkert, H, Schwarz, PEH, Shuldiner, AR, Sinisalo, J, Snieder, H, Sorensen, TIA, Spector, TD, Staessen, JA, Stefania, B, Thorsteinsdottir, U, Stumvoll, M, Tardif, JC, Tremoli, E, Tuomilehto, J, Uitterlinden, André, Uusitupa, M, Verbeek, ALM, Vermeulen, SH, Viikari, JS, Vitart, V, Volzke, H, Vollenweider, P, Waeber, G, Walker, M, Wallaschofski, H, Wareham, NJ, Watkins, H, Zeggini, E, Chakravarti, A, Clegg, DJ, Cupples, LA, Gordon-Larsen, P, Jaquish, CE, Rao, DC, Abecasis, GR, Assimes, TL, Barroso, I, Berndt, SI, Boehnke, M, Deloukas, P, Fox, CS, Groop, LC, Hunter, DJ, Ingelsson, E, Kaplan, RC, McCarthy, MI, Mohlke, KL, O'Connell, JR, Schlessinger, D, Strachan, DP, Stefansson, K, Duijn, Cornelia, Hirschhorn, JN, Lindgren, CM, Heid, IM, North, KE, Borecki, IB, Kutalik, Z, Loos, RJF, Winkler, TW, Justice, AE, Graff, M, Barata, L, Feitosa, MF, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpelainen, TO, Lu, YC, Magi, R, Mihailov, E, Pers, TH, Rueger, S, Teumer, A, Ehret, GB, Ferreira, T, Heard-Costa, NL, Karjalainen, J, Lagou, V, Mahajan, A, Neinast, MD, Prokopenko, I, Simino, J, Teslovich, TM, Jansen, R, Westra, HJ, White, CC, Absher, D, Ahluwalia, TS, Ahmad, Shahzad, Albrecht, E, Alves, AC, Bragg-Gresham, JL, de Craen, AJM, Bis, JC, Bonnefond, A, Boucher, G, Cadby, G, Cheng, YC, Chiang, CWK, Delgado, G, Demirkan, Ayse, Dueker, N, Eklund, N, Eiriksdottir, G, Eriksson, J, Feenstra, B, Fischer, K (Kirsten), Frau, F, Galesloot, TE, Geller, F, Goel, A, Gorski, M, Grammer, TB, Gustafsson, S, Haitjema, S, Hottenga, JJ (Jouke Jan), Huffman, JE, Jackson, AU, Jacobs, KB, Johansson, A, Kaakinen, M, Kleber, ME, Lahti, J, Leach, IM, Lehne, B, Liu, YF, Lo, KS, Lorentzon, M, Luan, J, Madden, PAF, Mangino, M, McKnight, B, Medina Gomez, Maria, Monda, KL, Montasser, ME, Muller, G, Muller-Nurasyid, M, Nolte, IM (Ilja), Panoutsopoulou, K, Pascoe, L, Paternoster, L, Rayner, NW, Renstrom, F, Rizzi, F, Rose, LM, Ryan, KA, Salo, P, Sanna, S, Scharnagl, H, Shi, JX, Smith, AV, Southam, L, Stancakova, A, Steinthorsdottir, V, Strawbridge, RJ, Sung, YJ, Tachmazidou, I, Tanaka, T, Thorleifsson, G, Trompet, S, Pervjakova, N, Tyrer, JP, Vandenput, L, Laan, Sander, van der Velde, Nathalie, van Setten, J, van Vliet-Ostaptchouk, JV, Verweij, N (Niek), Vlachopoulou, E, Waite, LL, Wang, SR, Wang, ZM, Wild, SH, Willenborg, C, Wilson, JF, Wong, A, Yang, Jiaqi, Yengo, L, Yerges-Armstrong, LM, Yu, L, Zhang, WH, Zhao, JH, Andersson, EA, Bakker, SJL, Baldassarre, D, Banasik, K, Barcella, M, Barlassina, C, Bellis, C, Benaglio, P, Blangero, J, Bluher, M, Bonnet, F, Bonnycastle, LL, Boyd, HA, Bruinenberg, M, Buchman, AS, Campbell, H, Chen, YDI, Chines, PS, Claudi-Boehm, S, Cole, J, Collins, FS, de Geus, EJC, de Groot, LCPGM (Lisette), Dimitriou, M, Duan, J, Enroth, S, Eury, E, Farmaki, AE, Forouhi, NG, Friedrich, N, Gejman, PV, Gigante, B, Glorioso, N, Go, AS, Gottesman, O, Grassler, J, Grallert, H, Grarup, N, Gu, YM, Broer, Linda, Ham, Annelies, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Heath, AC, Henders, AK, Hernandez, D, Hillege, H, Holmen, O, Hovingh, KG, Hui, J, Husemoen, LL, Hutri-Kahonen, N, Hysi, PG, Illig, T, De Jager, PL, Jalilzadeh, S, Jorgensen, T, Jukema, JW, Juonala, M, Kanoni, S, Karaleftheri, M, Khaw, KT, Kinnunen, L, Kittner, SJ, Koenig, W, Kolcic, I, Kovacs, P, Krarup, NT, Kratzer, W, Kruger, J, Kuh, D, Kumari, M, Kyriakou, T, Langenberg, C, Lannfelt, L, Lanzani, C, Lotay, V, Launer, LJ (Lenore), Leander, K, Lindstrom, J, Linneberg, A, Liu, YP, Lobbens, S, Luben, R, Lyssenko, V, Mannisto, S, Magnusson, PK, McArdle, WL, Menni, C, Merger, S, Milani, L, Montgomery, GW, Morris, AP, Narisu, N, Nelis, M, Ong, KK, Palotie, A, Perusse, L, Pichler, I, Pilia, MG, Pouta, A, Rheinberger, M, Ribel-Madsen, R, Richards, M, Rice, KM, Rice, TK, Rivolta, C, Salomaa, V, Sanders, AR, Sarzynski, MA, Scholtens, s, Scott, RA, Scott, WR, Sebert, S, Sengupta, S, Sennblad, B, Seufferlein, T, Silveira, A, Slagboom, PE (Eline), Smit, JH, Sparso, TH, Stirrups, K, Stolk, RP (Ronald), Stringham, HM, Swertz, MA, Swift, AJ, Syvanen, AC, Tan, ST, Thorand, B, Tonjes, A, Tremblay, A, Tsafantakis, E, van der Most, PJ, Volker, U, Vohl, MC, Vonk, JM, Waldenberger, M, Walker, RW, Wennauer, R, Widen, E, Willemsen, G, Wilsgaard, T, Wright, AF, Zillikens, M.C., Boon - van Dijk, Suzanne, Schoor, NM, Asselbergs, FW, de Bakker, PIW, Beckmann, JS, Beilby, J, Bennett, DA, Bergman, RN, Bergmann, S, Boger, CA, Boehm, BO, Boerwinkle, E, Boomsma, DI, Bornstein, SR, Bottinger, EP, Bouchard, C, Chambers, JC, Chanock, SJ, Chasman, DI, Cucca, F, Cusi, D, Dedoussis, G, Erdmann, J, Eriksson, JG, Evans, DA, de Faire, U, Farrall, M, Ferrucci, L, Ford, I, Franke, L, Franks, PW, Froguel, P, Gansevoort, RT, Gieger, C, Gronberg, H, Gudnason, V, Gyllensten, U, Hall, P, Hamsten, A, van der Harst, P, Hayward, C, Heliovaara, M, Hengstenberg, C, Hicks, AA, Hingorani, A, Hofman, Bert, Hu, F, Huikuri, HV, Hveem, K, James, AL, Jordan, JM, Jula, A, Kahonen, M, Kajantie, E, Kathiresan, S, Kiemeney, LALM, Kivimaki, M, Knekt, PB, Koistinen, HA, Kooner, JS, Koskinen, S, Kuusisto, J, Maerz, W, Martin, NG, Laakso, M, Lakka, TA, Lehtimaki, T, Lettre, G, Levinson, DF, Lind, L, Lokki, ML, Mantyselka, P, Melbye, M, Metspalu, A, Mitchell, BD, Moll, FL, Murray, JC, Musk, AW, Nieminen, MS, Njolstad, I, Ohlsson, C, Oldehinkel, AJ (A.), Oostra, Ben, Palmer, LJ, Pankow, JS, Pasterkamp, G, Pedersen, NL, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Psaty, BM, Qi, L, Quertermous, T, Raitakari, OT, Rankinen, T, Rauramaa, R, Ridker, PM, Rioux, JD, Rivadeneira, Fernando, Rotter, JI, Rudan, I, den Ruijter, HM, Saltevo, J, Sattar, N, Schunkert, H, Schwarz, PEH, Shuldiner, AR, Sinisalo, J, Snieder, H, Sorensen, TIA, Spector, TD, Staessen, JA, Stefania, B, Thorsteinsdottir, U, Stumvoll, M, Tardif, JC, Tremoli, E, Tuomilehto, J, Uitterlinden, André, Uusitupa, M, Verbeek, ALM, Vermeulen, SH, Viikari, JS, Vitart, V, Volzke, H, Vollenweider, P, Waeber, G, Walker, M, Wallaschofski, H, Wareham, NJ, Watkins, H, Zeggini, E, Chakravarti, A, Clegg, DJ, Cupples, LA, Gordon-Larsen, P, Jaquish, CE, Rao, DC, Abecasis, GR, Assimes, TL, Barroso, I, Berndt, SI, Boehnke, M, Deloukas, P, Fox, CS, Groop, LC, Hunter, DJ, Ingelsson, E, Kaplan, RC, McCarthy, MI, Mohlke, KL, O'Connell, JR, Schlessinger, D, Strachan, DP, Stefansson, K, Duijn, Cornelia, Hirschhorn, JN, Lindgren, CM, Heid, IM, North, KE, Borecki, IB, Kutalik, Z, and Loos, RJF
- Abstract
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men <= 50y, men > 50y, women <= 50y, women > 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR< 5%) age-specific effects, of which 11 had larger effects in younger (< 50y) than in older adults (>= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shap
- Published
- 2015
33. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
- Author
-
Bradshaw, EM, Chibnik, LB, Keenan, BT, Ottoboni, L, Raj, T, Tang, A, Rosenkrantz, LL, Imboywa, S, Lee, M, Von Korff, A, Morris, MC, Evans, DA, Johnson, K, Sperling, RA, Schneider, JA, Bennett, DA, De Jager, PL, and Initi, ADN
- Published
- 2013
34. A genome-wide association study of depressive symptoms
- Author
-
Hek, K, Demirkan, A, Lahti, J, Terracciano, A, Teumer, A, Cornelis, MC, Amin, N, Bakshis, E, Baumert, J, Ding, J, Liu, Y, Marciante, K, Meirelles, O, Nalls, MA, Sun, YV, Vogelzangs, N, Yu, L, Bandinelli, S, Benjamin, EJ, Bennett, DA, Boomsma, D, Cannas, A, Coker, LH, De Geus, E, De Jager, PL, Diez-Roux, AV, Purcell, S, Hu, FB, Rimm, EB, Hunter, DJ, Jensen, MK, Curhan, G, Rice, K, Penman, AD, Rotter, JI, Sotoodehnia, N, Emeny, R, Eriksson, JG, Evans, DA, Ferrucci, L, Fornage, M, Gudnason, V, Hofman, A, Illig, T, Kardia, S, Kelly-Hayes, M, Koenen, K, Kraft, P, Kuningas, M, Massaro, JM, Melzer, D, Mulas, A, Mulder, CL, Murray, A, Oostra, BA, Palotie, A, Penninx, B, Petersmann, A, Pilling, LC, Psaty, B, Rawal, R, Reiman, EM, Schulz, A, Shulman, JM, Singleton, AB, Smith, AV, Sutin, AR, and Uitterlinden, AG
- Abstract
Background: Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. Methods: In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p
- Published
- 2013
35. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 2
- Author
-
Seshadri, S, Beiser, A, Au, R, Wolf, PA, Evans, DA, Wilson, RS, Petersen, RC, Knopman, DS, Rocca, WA, Kawas, CH, Corrada, MM, Plassman, BL, Langa, KM, and Chui, HC
- Abstract
This article focuses on the effects of operational differences in case ascertainment on estimates of prevalence and incidence of cognitive impairment and/or dementia of the Alzheimer type. Experience and insights are discussed by investigators from the Framingham Heart Study, the East Boston Senior Health Project, the Chicago Health and Aging Project, the Mayo Clinic Study of Aging, the Baltimore Longitudinal Study of Aging, and the Aging, Demographics, and Memory Study. There is a general consensus that the single most important factor determining prevalence estimates of Alzheimer's disease (AD) is the severity of cognitive impairment used as a threshold to define cases. Studies that require a level of cognitive impairment in which persons are unable to provide self-care will have much lower estimates than the studies aimed at identifying persons in the earliest stages of AD. There are limited autopsy data from the aforementioned epidemiological studies to address accuracy in the diagnosis of etiological subtype, namely the specification of AD alone or in combination with other types of pathology. However, other community-based cohort studies show that many persons with mild cognitive impairment and also some persons without dementia or mild cognitive impairment meet pathological criteria for AD, thereby suggesting that the number of persons who would benefit from an effective secondary prevention intervention is probably higher than the published prevalence estimates. Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies. © 2011 The Alzheimers Association. All rights reserved.
- Published
- 2011
36. Genetic diversity is a predictor of mortality in humans
- Author
-
Bihlmeyer, NA, Brody, JA, Smith, AV, Lunetta, KL, Nalls, M, Smith, JA, Tanaka, T, Davies, G, Yu, L, Mirza, Saira, Teumer, A, Coresh, J, Pankow, JS, Franceschini, N, Scaria, A, Oshima, J, Psaty, BM, Gudnason, V, Eiriksdottir, G, Harris, TB, Li, HY, Karasik, D, Kiel, DP, Garcia, M, Liu, YM, Faul, JD, Kardia, SLR, Zhao, W, Ferrucci, L, Allerhand, M, Liewald, DC, Redmond, P, Starr, JM, De Jager, PL, Evans, DA, Direk, Nese, Ikram, Arfan, Uitterlinden, André, Homuth, G, Lorbeer, R, Grabe, HJ, Launer, L, Murabito, JM, Singleton, AB, Weir, DR, Bandinelli, S, Deary, IJ, Bennett, DA, Tiemeier, Henning, Kocher, T, Lumley, T, Arking, DE, Bihlmeyer, NA, Brody, JA, Smith, AV, Lunetta, KL, Nalls, M, Smith, JA, Tanaka, T, Davies, G, Yu, L, Mirza, Saira, Teumer, A, Coresh, J, Pankow, JS, Franceschini, N, Scaria, A, Oshima, J, Psaty, BM, Gudnason, V, Eiriksdottir, G, Harris, TB, Li, HY, Karasik, D, Kiel, DP, Garcia, M, Liu, YM, Faul, JD, Kardia, SLR, Zhao, W, Ferrucci, L, Allerhand, M, Liewald, DC, Redmond, P, Starr, JM, De Jager, PL, Evans, DA, Direk, Nese, Ikram, Arfan, Uitterlinden, André, Homuth, G, Lorbeer, R, Grabe, HJ, Launer, L, Murabito, JM, Singleton, AB, Weir, DR, Bandinelli, S, Deary, IJ, Bennett, DA, Tiemeier, Henning, Kocher, T, Lumley, T, and Arking, DE
- Abstract
Background: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations. Moreover, the presence of numerous segregating small effect alleles that influence traits that directly impact health directly raises the question as to whether global measures of genomic variation are themselves associated with human health and disease. Results: We performed a meta-analysis of 17 cohorts followed prospectively, with a combined sample size of 46,716 individuals, including a total of 15,234 deaths. We find a significant association between increased heterozygosity and survival (P = 0.03). We estimate that within a single population, every standard deviation of heterozygosity an individual has over the mean decreases that person's risk of death by 1.57%. Conclusions: This effect was consistent between European and African ancestry cohorts, men and women, and major causes of death (cancer and cardiovascular disease), demonstrating the broad positive impact of genomic diversity on human survival.
- Published
- 2014
37. Education programs for people living with chronic pain: a scoping review
- Author
-
Wang Hai-Ying, Grech Carol, Evans David, and Jayasekara Rasika
- Subjects
patient education ,chronic pain management ,scoping review ,taxonomy ,pain ,Nursing ,RT1-120 - Abstract
The aim of this scoping review was to provide evidence for health practitioners to improve patient education practice for chronic pain management.
- Published
- 2021
- Full Text
- View/download PDF
38. Abdominal Surgery: An aid to stoma fashioning
- Author
-
Evans, DA
- Subjects
Technical Section: Technical Tutorials, Notes and Tips - Published
- 2002
39. Stigma and discrimination tendencies towards COVID-19 survivors: Evidence from a nationwide population-based survey in Ghana.
- Author
-
Eric Osei, Hubert Amu, Prince Kubi Appiah, Solomon Boamah Amponsah, Evans Danso, Samuel Oppong, Comfort Worna Lotse, Bright Emmanuel Owusu, Simon Azure Agongo, Eliasu Yakubu, and Gideon Kye-Duodu
- Subjects
Public aspects of medicine ,RA1-1270 - Abstract
Historically, infectious diseases have generated fears among populations. Unhealthy handling of these fears result in the stigma and discrimination of infected patients. Globally, measures taken so far by governments to curb the spread of the novel coronavirus disease-2019 (COVID-19) pandemic, although helpful, have created fears in people. Consequently, there are reported Ghanaian media cases of stigmatisation against persons who were infected and recovered from COVID-19. However, these reports remain unsubstantiated. This study, therefore, sought to examine stigma and discriminatory tendencies towards COVID-19 survivors among the adult population in Ghana. This was a population-based cross-sectional study among 3,259 adults. A multi-stage sampling technique was used to recruit study participants. Descriptive and inferential statistics comprising frequency, percentage, chi-square, and multivariable logistic regression were employed in analysing the data. Knowledge on COVID-19 was poor among 33.6% of the participants. Forty-three per cent had a good attitude towards COVID-19. Nearly half (45.9%) exhibited stigma and discriminatory tendencies towards COVID-19 survivors. Participants who had poor COVID-19 related knowledge (aOR = 1.91, 95%CI = 1.59-2.29, p
- Published
- 2022
- Full Text
- View/download PDF
40. Historia, memoria y reparación: usos y abusos en la construcción del Museo de Memoria de Colombia (2011-2018)
- Author
-
Evans David Steven Gama Torres
- Subjects
memoria histórica ,víctimas ,museo ,reparación ,conflicto armado ,Philosophy. Psychology. Religion ,Social sciences (General) ,H1-99 - Abstract
En busca de responder a la pregunta, ¿Cómo el Museo de Memoria de Colombia contribuye a la reparación de las víctimas? Se analiza la relación entre memoria e historia, así como los usos de la memoria y su relación con las víctimas en Colombia a través del Centro Nacional de Memoria Histórica, también, la importancia y cómo se piensa el Museo de Memoria de Colombia.
- Published
- 2019
- Full Text
- View/download PDF
41. Temporal changes in litterfall and potential nutrient return in cocoa agroforestry systems under organic and conventional management, Ghana
- Author
-
Michael Asigbaase, Evans Dawoe, Barry H. Lomax, and Sofie Sjogersten
- Subjects
Agroforestry ,Ghana ,Litterfall ,Macro-nutrients ,Micro-nutrients ,Organic cocoa ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Litterfall is a critical link between vegetation and soils by which nutrients are returned to the soils, thus the amount and pattern of litterfall regulates nutrient cycling, soil fertility and primary productivity for most terrestrial ecosystems. We quantified, analyzed and compared macro- and micro-nutrients return through litterfall in organic and conventional cocoa agroforestry systems in Suhum, Ghana. We further assessed the contribution of shade tree species to litterfall and nutrient dynamics. The annual pattern of litterfall was affected by seasonality, with a major peak in the dry season and minor peaks during the rainy season. In terms of annual fractional litterfall, mean leaf litter from shade tree species was significantly higher (50 %) in organic systems (5.0 ± 0.5 Mg ha−1 yr−1) compared to conventional systems (3.3 ± 0.6 Mg ha−1 yr−1). Whereas cocoa leaves (45.0 %) were the predominant fraction of annual litterfall from conventional farms, both shade leaves (40.0 %) and cocoa leaves (39.4 %) dominated litterfall from organic farms. The return of primary macro-nutrients (P and K), secondary macro-nutrients (Ca, Mg and S) and micro-nutrients (Mn, B, Cu, Zn and Mo) via litterfall varied significantly with season, and annual return of nutrients were similar in organic and conventional cocoa systems. Shade tree leaf litter accounted for 30–47 % of annual macro- and micro-nutrient return (except Ni and Zn) in organic cocoa systems versus 20–35 % in conventional cocoa systems. The results emphasize the complementary role of the different shade tree species which compose organic and conventional cocoa systems in nutrient recycling. We conclude that organic management of cocoa agroforestry systems ensure nutrients return similar to those receiving synthetic fertilizer inputs, highlighting its potential to support cocoa production.
- Published
- 2021
- Full Text
- View/download PDF
42. Addressing the resilience of tomato farmers in Ghana facing a double exposure from climate and market
- Author
-
Kenza Benabderrazik, Laurence Jeangros, Birgit Kopainsky, Evans Dawoe, Jonas Joerin, and Johan Six
- Subjects
climate change ,ghana ,market ,resilience ,social-ecological system ,tomato ,transformation ,Biology (General) ,QH301-705.5 ,Ecology ,QH540-549.5 - Abstract
Ghanaian tomato farmers are severely impacted by changing climate and related more frequent and extreme weather events such as drought and heavy rainfall. Furthermore, tomato production represents one of the main sources of income for these farmers, which leaves them highly exposed to market price variations. However, the full impact of changing climate and price variations for these farmers has not been assessed. Here, we examined how Ghanaian tomato farmers experience and respond to a double exposure from climate and market related shocks. The objectives were threefold: (i) to investigate how farmers in two different agroecological zones (savannah and semi-equatorial) experience climate and market shocks, (ii) to examine the major response strategies implemented in face of this double exposure, and (iii) to identify paths toward systemic changes to enhance resilience. A survey was conducted with 344 tomato smallholder farmers in the two agroecological zones. The results from the survey were complemented by semi-structured interviews and focus groups. We found that farmers are severely exposed to climate and market shocks, which causes a reduction in both production activities and revenues. A set of agricultural and water management practices, such as crop rotation, supplementary fertilization, and water tanks, have been adopted by farmers as response mechanisms to climate variations. However, no response mechanisms, other than agricultural diversification, are in place yet to face the economic shocks. Thus, enhancing systemic resilience becomes particularly important to face this double exposure and restructure and change feedback mechanisms within the current system. The reestablishment of tomato processing plants or formalizing the stakeholders’ network could both be ways to integrate value-chain stakeholders and support appropriate structures. Encompassing both climate and trading attributes through specific agro-food policies are much-needed for a sustainable and resilient transformation of the tomato production system.
- Published
- 2022
- Full Text
- View/download PDF
43. SPECIFYING ADVERSE DRUG REACTIONS BY FORMULATING CONTEXTS THROUGH CLARIT PROCESSING OF MEDICAL ABSTRACTS
- Author
-
RIKKEN, F, EVANS, DA, VOS, R, and Groningen University Institute for Drug Exploration (GUIDE)
- Published
- 1994
44. Post-operative blood loss following cardio-pulmonary bypass in children
- Author
-
William J. Brawn, Babulal Sethia, Roger Holder, and Evans Da
- Subjects
Pulmonary and Respiratory Medicine ,Excessive Bleeding ,Heart Defects, Congenital ,Reoperation ,medicine.medical_specialty ,Hemorrhage ,law.invention ,Body Temperature ,Esophagus ,Postoperative Complications ,law ,Cardiopulmonary bypass ,Medicine ,Humans ,Derivation ,Prospective Studies ,Risk factor ,Prospective cohort study ,Child ,Cardiopulmonary Bypass ,business.industry ,Infant ,General Medicine ,Nomogram ,Prognosis ,Surgery ,El Niño ,Anesthesia ,Child, Preschool ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
Significant post-operative bleeding may occur following cardio-pulmonary bypass, sometimes necessitating early re-exploration. Two questions were asked by this study. Firstly, in children undergoing cardio-pulmonary bypass, can pre-operative, operative and immediately post-operative variables be used to predict post-operative blood loss? Secondly, in the same patient group, can the same variables be used to predict the surgical intervention of re-exploration for excessive bleeding within 12 h of surgery? In a prospective study of patients operated on in a 9-month period, bleeding fell rapidly in the first 3 h after surgery and early re-exploration for bleeding was necessary in 8 of the 206 patients. The only significant predictor of post-operative blood loss was minimum oesophageal temperature, low values being associated with greater blood loss (correlation r = -0.19 (P < 0.05)). With regard to re-exploration for bleeding, a long bypass time (P < 0.05) and abnormal pre-operative coagulation indices (P < 0.01) were significant and independent predictors. The data were also used to create a practical nomogram relating re-exploration for bleeding to hourly post-operative blood loss.
- Published
- 1994
45. Carbon storage in cocoa growing systems across different agroecological zones in Ghana
- Author
-
John Tennyson Afele, Evans Dawoe, Akwasi Adutwum Abunyewa, Victor Afari-Sefa, and Richard Asare
- Subjects
Climate change, Cocoa, REDD , shaded cocoa, full sun cocoa ,Agriculture - Abstract
Shade grown cocoa systems have been credited with stocking high quantities of carbon and therefore possess the potential to mitigate climate change and help achieve targets of the United Nations Collaborative Program on Reduced Emissions from Deforestation and Forest Degradation (REDD+). This study quantifies and compares carbon stored as well as estimated cocoa yields in two shade management types (i.e., shaded and full sun) across three agroecological zones: Dry Semi-Deciduous Fire Zone (DSFZ), Moist Evergreen Zone (MEZ) and Upland Evergreen Moist Zone (UEMZ) in Ghana. Results show that Soil organic carbon (SOC) stored decreased with increasing soil depth across all agroecological zones. Cocoa farms with shade trees stored 6 times more soil carbon (35.90±1.56 Mg C ha-1) compared to the full sun systems (5.98±1.56 Mg C ha-1). Carbon stocks in the DSFZ and the MEZ were 61.73±1.02 Mg C/ha and 67.46±1.02 Mg C ha-1 respectively whiles the UEMZ recorded 85.10 Mg C ha-1. Across agroecological zones, pod count in the UEMZ and the MEZ were similar but varied from that of the DSFZ, which recorded the least. Wilting of pods and cherrelles, was minimal and similar in the UMEZ and the MEZ but was significantly higher in the DSFZ. It is recommended that farmers should be encouraged through strong policies to adopt the integration of shade trees in the production of cocoa in Ghana to mitigate the effects of climate change.
- Published
- 2021
46. A Comparative Study of Carbon Storage in Two Cocoa (Theobroma cacao) Shade-Types and a Teak Plantation in the Moist Semi-deciduous Forest Zone of Ghana.
- Author
-
Eunice Nimo, Evans Dawoe, and John Tennyson Afele
- Subjects
Climate change, Cocoa, Shade types, Teak plantation, Carbon storage ,Agriculture - Abstract
on life, it is important that steps are taken to mitigate its effects. With the intensification of cocoa production, there has been a shift in traditional cocoa farming over the years leading to the removal of shade trees, hence, removal of carbon sinks. This study was carried out to compare the amount of carbon stored in cocoa ecosystems to that of a 20 years teak plantation and to calculate the trade-off of carbon between the two systems. Cocoa farms of similar ages (20 years) were selected in which three-subplots were demarcated on each farm at Piase in the Bosomtwe District. Tree Diameter at Breast Height (DBH) was measured and soils samples were collected and analyzed for organic carbon percentage and bulk density. One-way Analysis of Variance was used to analyze above and belowground tree carbon and two-way analysis of variance was used to analyze soil organic carbon stored. Teak plantation recorded higher carbon stock (739.33±2.24 Mg C.ha-1) compared to full sun cocoa (9.36±2.24 Mg C.ha-1). Soil organic carbon across the three farms showed significant (p = 0.0010) variations with depths. The 0-20 cm soil depth stored significantly more (p = 0.0000) organic carbon compared to 20-40 cm soil depth. Total soil carbon stored revealed significant differences amongst the various farms with the full sun (40.857±0.52 Mg C.ha-1) being the least whilst the teak plantation stored the highest (72.42±0.52 Mg C.ha-1). Total carbon (above-ground tree carbon + below-ground tree carbon + soil organic carbon) showed significant difference (p= 0.0000) between land use types with shaded cocoa farm (74.3±0.89 Mg C.ha-1), full sun cocoa farm (32.02±0.89Mg C.ha-1) and that of the teak plantation (950.91±0.89 Mg C.ha-1) respectively. Traditional cocoa ecosystem (shaded cocoa farms) has the potential to store carbon significantly higher than that of the full sun systems.
- Published
- 2021
47. Effects of neonatal nutrition interventions on neonatal mortality and child health and development outcomes: A systematic review
- Author
-
Aamer Imdad, Faseeha Rehman, Evans Davis, Deepika Ranjit, Gamael S. S. Surin, Suzanna L. Attia, Sarah Lawler, Abigail A. Smith, and Zulfiqar A. Bhutta
- Subjects
Social Sciences - Abstract
Abstract Background The last two decades have seen a significant decrease in mortality for children
- Published
- 2021
- Full Text
- View/download PDF
48. Vitamin E and cognitive decline in older persons. (Abstracts)
- Author
-
Morris, MC, Evans, DA, and Bienias, JL
- Subjects
Cognition disorders in old age -- Prevention ,Antioxidants -- Physiological aspects ,Nervous system -- Degeneration ,Health ,Prevention ,Physiological aspects - Abstract
Morris MC, Evans DA, Bienias JL, et al. Arch Neurol 2002;59:1125-1132. BACKGROUND: Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases. OBJECTIVE: To examine whether intake of antioxidant [...]
- Published
- 2002
49. Space-time analysis and mapping of prevalence rate of tuberculosis in Ghana
- Author
-
Iddrisu Wahab Abdul, Sylvia Ankamah, Abdul-Karim Iddrisu, and Evans Danso
- Subjects
Science - Abstract
Background: Global fight against tuberculosis (TB) has received increasing attention over the years. However, the disease remains one of the top-most global health problems, especially in Sub-Saharan Africa and Ghana. Aims: This paper examined geographical (regional) and seasonal distribution of TB cases providing relative risk of TB exposure in Ghana and step by step procedure to perform the analysis. Methods and material: We modelled reported TB cases between 2015 and 2018 using wavelet analysis and applied maximum covariance analysis (MCA) to determine regional and seasonal patterns and the risk of TB exposure in Ghana. This study is based on the old administrative regions of Ghana. Results: More TB cases were recorded in the Greater Accra and Ashanti regions and less cases in the rest of the regions. There is significant increase in the number of TB cases from 2015 to 2018. High number of TB cases is observed in the dry season relative to the rainy season. There is high variability in TB prevalence with high prevalence moving towards the Southern part of Ghana. Conclusion: The study highlights that TB cases is clustered in space and time and that even at small spatial scale, differences in prevalence can be substantial. The prevelance of TB exposure is higher in the dry season relative to the rainy season. Hence, enough resources should be timely provided during the dry season as well as intensifying preventive strategies to control the spread of the disease. Keywords: Space-time modelling, Tuberculosis, Tuberculosis prevalence, Wavelet analysis, Wavelet cluster analysis
- Published
- 2020
- Full Text
- View/download PDF
50. Farmer networks and agrobiodiversity interventions: the unintended outcomes of intended change
- Author
-
Marney E. Isaac, Hanson Nyantakyi-Frimpong, Petr Matouš, Evans Dawoe, and Luke C. N. Anglaaere
- Subjects
agroecology ,agroforestry ,diversified agroecosystems ,interventions ,social-ecological systems ,social network analysis ,Biology (General) ,QH301-705.5 ,Ecology ,QH540-549.5 - Abstract
Agroecosystem strategies to enhance agrobiodiversity can curb many of the negative impacts associated with current food production systems. With rising interest in agrobiodiversity and agroforestry as farming interventions that confer ecological and socioeconomic benefits, understanding the intended pathways of interventions is important for successful agroecological transformations. Yet, the patterns of agrobiodiversity introduction and adoption remain elusive. Drawing upon social network research from the regions of Ghana where cocoa (Theobroma cacao) is grown, we synthesize the relationships between agroforestry interventions, information networks, and the adoption of diversified agroecosystems. We illustrate middle-level patterns from independent studies in three regions of Ghana and nearly 500 farmer interviews. Strong structural indicators at the network level are linked to agrobiodiversity; farmers in larger, less dense information networks with ties to external organizations tend to have higher reported and measured agrobiodiversity. Remarkably, these trends were found in environmentally and socio-culturally different contexts in Ghana. However, these trends do not, in all cases, scale to the community level. For example, we did not observe any clear relationship between the density of community networks and the measures of agrobiodiversity at the community scale. This may be on account of the type of agrobiodiversity measure applied (above-ground biomass) to assess community-level outcomes. Selection of environmental attributes with meaningful spillover effects, such as pest management, would more likely uncover nontrivial network effects at the collective level. Our findings support that both innovation and cooperation are indispensable for successful agrobiodiversity interventions, and that networks can operate to overcome negative outcomes of agrobiodiversity. Based on these studies, we conclude that agrobiodiversity adoption via interventions and established farmer-to-farmer networks may trigger the formation of other, observation-based networks that draw in socially distant actors. Our research strategy of ex-post qualitative comparisons allowed for in-depth insight into the complexities of information networks and agrobiodiversity adoption but also generated new hypotheses on the role of social networks in diversified farming systems.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.