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Your search keyword '"Evans, Cariad M."' showing total 14 results
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14 results on '"Evans, Cariad M."'

1. Publisher Correction: Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Author

Lindsey, Benjamin B., Villabona-Arenas, Ch. Julián, Campbell, Finlay, Keeley, Alexander J., Parker, Matthew D., Shah, Dhruv R., Parsons, Helena, Zhang, Peijun, Kakkar, Nishchay, Gallis, Marta, Foulkes, Benjamin H., Wolverson, Paige, Louka, Stavroula F., Christou, Stella, State, Amy, Johnson, Katie, Raza, Mohammad, Hsu, Sharon, Jombart, Thibaut, Cori, Anne, Evans, Cariad M., Partridge, David G., Atkins, Katherine E., Hué, Stéphane, and de Silva, Thushan I.

Published
2022
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2. Characterising within-hospitalSARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Author

Lindsey, Benjamin B., Villabona-Arenas, Ch. Julián, Campbell, Finlay, Keeley, Alexander J., Parker, Matthew D., Shah, Dhruv R., Parsons, Helena, Zhang, Peijun, Kakkar, Nishchay, Gallis, Marta, Foulkes, Benjamin H., Wolverson, Paige, Louka, Stavroula F., Christou, Stella, State, Amy, Johnson, Katie, Raza, Mohammad, Hsu, Sharon, Jombart, Thibaut, Cori, Anne, Evans, Cariad M., Partridge, David G., Atkins, Katherine E., Hué, Stéphane, and de Silva, Thushan I.

Published
2022
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3. Guidelines for the management of norovirus outbreaks in acute and community health and social care settings

Author

Chadwick, Paul R., primary, Trainor, Eamonn, additional, Marsden, Gemma L., additional, Mills, Samuel, additional, Chadwick, Claire, additional, O’Brien, Sarah J., additional, Evans, Cariad M., additional, Mullender, Claire, additional, Strazds, Pixy, additional, Turner, Sarah, additional, Weston, Valya, additional, Toleman, Michelle S., additional, de Barros, Clara, additional, Kontkowski, Graziella, additional, and Bak, Aggie, additional

Published
2023
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7. Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Author

Lindsey, Benjamin B, Villabona-Arenas, Ch Julián, Campbell, Finlay, Keeley, Alexander J, Parker, Matthew D, Shah, Dhruv R, Parsons, Helena, Zhang, Peijun, Kakkar, Nishchay, Gallis, Marta, Foulkes, Benjamin H, Wolverson, Paige, Louka, Stavroula F, Christou, Stella, State, Amy, Johnson, Katie, Raza, Mohammad, Hsu, Sharon, Jombart, Thibaut, Cori, Anne, Group, Sheffield COVID-19 Genomics, COVID-19 Genomics UK (COG-UK) Consortium, CMMID COVID-19 Working Group, Evans, Cariad M, Partridge, David G, Atkins, Katherine E, Hué, Stéphane, De Silva, Thushan I, Lindsey, Benjamin B [0000-0003-4227-2592], Villabona-Arenas, Ch Julián [0000-0001-9928-3968], Keeley, Alexander J [0000-0001-9386-1157], Parker, Matthew D [0000-0003-2999-3870], Shah, Dhruv R [0000-0002-6198-8273], Foulkes, Benjamin H [0000-0001-8532-3295], Wolverson, Paige [0000-0003-2709-0686], Hsu, Sharon [0000-0003-2356-9155], Partridge, David G [0000-0002-0417-2016], Atkins, Katherine E [0000-0001-5250-0558], Hué, Stéphane [0000-0002-8580-6905], de Silva, Thushan I [0000-0002-6498-9212], and Apollo - University of Cambridge Repository

Subjects
Cross Infection, Molecular Epidemiology, Multidisciplinary, SARS-CoV-2, Health Personnel, Science, COVID-19, General Physics and Astronomy, Bayes Theorem, Genome, Viral, Genomics, General Chemistry, Hospitals, United Kingdom, General Biochemistry, Genetics and Molecular Biology, Disease Outbreaks, Cohort Studies, Humans, Pandemics
Abstract

Hospital outbreaks of COVID19 result in considerable mortality and disruption to healthcare services and yet little is known about transmission within this setting. We characterise within hospital transmission by combining viral genomic and epidemiological data using Bayesian modelling amongst 2181 patients and healthcare workers from a large UK NHS Trust. Transmission events were compared between Wave 1 (1st March to 25th July 2020) and Wave 2 (30th November 2020 to 24th January 2021). We show that staff-to-staff transmissions reduced from 31.6% to 12.9% of all infections. Patient-to-patient transmissions increased from 27.1% to 52.1%. 40%-50% of hospital-onset patient cases resulted in onward transmission compared to 4% of community-acquired cases. Control measures introduced during the pandemic likely reduced transmissions between healthcare workers but were insufficient to prevent increasing numbers of patient-to-patient transmissions. As hospital-acquired cases drive most onward transmission, earlier identification of nosocomial cases will be required to break hospital transmission chains.

Published
2022

8. Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant

Author

Colton, Hayley, primary, Greenfield, Diana M., additional, Snowden, John A., additional, Miller, Paul D.E., additional, Morley, Nicholas J., additional, Wright, Josh, additional, Darton, Thomas C., additional, Evans, Cariad M., additional, and de Silva, Thushan I., additional

Published
2021
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9. Diagnosis of SARS-CoV-2 Infection with LamPORE, a High-Throughput Platform Combining Loop-Mediated Isothermal Amplification and Nanopore Sequencing

Author

Peto, Leon, primary, Rodger, Gillian, additional, Carter, Daniel P., additional, Osman, Karen L., additional, Yavuz, Mehmet, additional, Johnson, Katie, additional, Raza, Mohammad, additional, Parker, Matthew D., additional, Wyles, Matthew D., additional, Andersson, Monique, additional, Justice, Anita, additional, Vaughan, Alison, additional, Hoosdally, Sarah, additional, Stoesser, Nicole, additional, Matthews, Philippa C., additional, Eyre, David W., additional, Peto, Timothy E. A., additional, Carroll, Miles W., additional, de Silva, Thushan I., additional, Crook, Derrick W., additional, Evans, Cariad M., additional, and Pullan, Steven T., additional

Published
2021
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10. Diagnosis of SARS-CoV-2 infection with LamPORE, a high-throughput platform combining loop-mediated isothermal amplification and nanopore sequencing

Author

Peto, Leon, primary, Rodger, Gillian, additional, Carter, Daniel P, additional, Osman, Karen L, additional, Yavuz, Mehmet, additional, Johnson, Katie, additional, Raza, Mohammad, additional, Parker, Matthew D, additional, Wyles, Matthew D, additional, Andersson, Monique, additional, Justice, Anita, additional, Vaughan, Alison, additional, Hoosdally, Sarah, additional, Stoesser, Nicole, additional, Matthews, Philippa C, additional, Eyre, David W, additional, Peto, Timothy EA, additional, Carroll, Miles W, additional, de Silva, Thushan I, additional, Crook, Derrick W, additional, Evans, Cariad M, additional, and Pullan, Steven T, additional

Published
2020
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11. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Author

Korber, Bette, primary, Fischer, Will M., additional, Gnanakaran, Sandrasegaram, additional, Yoon, Hyejin, additional, Theiler, James, additional, Abfalterer, Werner, additional, Hengartner, Nick, additional, Giorgi, Elena E., additional, Bhattacharya, Tanmoy, additional, Foley, Brian, additional, Hastie, Kathryn M., additional, Parker, Matthew D., additional, Partridge, David G., additional, Evans, Cariad M., additional, Freeman, Timothy M., additional, de Silva, Thushan I., additional, McDanal, Charlene, additional, Perez, Lautaro G., additional, Tang, Haili, additional, Moon-Walker, Alex, additional, Whelan, Sean P., additional, LaBranche, Celia C., additional, Saphire, Erica O., additional, Montefiori, David C., additional, Angyal, Adrienne, additional, Brown, Rebecca L., additional, Carrilero, Laura, additional, Green, Luke R., additional, Groves, Danielle C., additional, Johnson, Katie J., additional, Keeley, Alexander J., additional, Lindsey, Benjamin B., additional, Parsons, Paul J., additional, Raza, Mohammad, additional, Rowland-Jones, Sarah, additional, Smith, Nikki, additional, Tucker, Rachel M., additional, Wang, Dennis, additional, and Wyles, Matthew D., additional

Published
2020
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13. Phase I Safety and Immunogenicity Study of a Candidate Meningococcal Disease Vaccine Based on Neisseria lactamica Outer Membrane Vesicles

Author

Gorringe, Andrew R., primary, Taylor, Stephen, additional, Brookes, Charlotte, additional, Matheson, Mary, additional, Finney, Michelle, additional, Kerr, Moyra, additional, Hudson, Michael, additional, Findlow, Jamie, additional, Borrow, Ray, additional, Andrews, Nick, additional, Kafatos, George, additional, Evans, Cariad M., additional, and Read, Robert C., additional

Published
2009
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14. Phase I Safety and Immunogenicity Study of a Candidate Meningococcal Disease Vaccine Based on Neisseria lactamicaOuter Membrane Vesicles

Author

Gorringe, Andrew R., Taylor, Stephen, Brookes, Charlotte, Matheson, Mary, Finney, Michelle, Kerr, Moyra, Hudson, Michael, Findlow, Jamie, Borrow, Ray, Andrews, Nick, Kafatos, George, Evans, Cariad M., and Read, Robert C.

Abstract

ABSTRACTNatural immunity to meningococcal disease in young children is associated epidemiologically with carriage of commensal Neisseriaspecies, including Neisseria lactamica. We have previously demonstrated that outer membrane vesicles (OMVs) from N. lactamicaprovide protection against lethal challenge in a mouse model of meningococcal septicemia. We evaluated the safety and immunogenicity of an N. lactamicaOMV vaccine in a phase I placebo-controlled, double-blinded clinical trial. Ninety-seven healthy young adult male volunteers were randomized to receive three doses of either an OMV vaccine or an Alhydrogel control. Subsequently, some subjects who had received the OMV vaccine also received a fourth dose of OMV vaccine, 6 months after the third dose. Injection site reactions were more frequent in the OMV-receiving group, but all reactions were mild or moderate in intensity. The OMV vaccine was immunogenic, eliciting rises in titers of immunoglobulin G (IgG) against the vaccine OMVs, together with a significant booster response, as determined by an enzyme-linked immunosorbent assay. Additionally, the vaccine induced modest cross-reactive immunity to six diverse strains of serogroup B Neisseria meningitidis, including IgG against meningococcal OMVs, serum bactericidal antibodies, and opsonophagocytic activity. The percentages of subjects showing =4-fold rises in bactericidal antibody titer obtained were similar to those previously reported for the Norwegian meningococcal OMV vaccine against the same heterologous meningococcal strain panel. In conclusion, this N. lactamicaOMV vaccine is safe and induces a weak but broad humoral immune response to N. meningitidis.

Published
2009
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