8 results on '"Eva R. Parker"'
Search Results
2. Reducing the carbon footprint of travel to an international dermatology conference: a case study of the Medical Dermatology Society's Carbon Footprint Program
- Author
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Annika Belzer, Misha Rosenbach, Eva R. Parker, John S. Barbieri, and Caroline A. Nelson
- Subjects
Dermatology - Published
- 2022
3. Healthcare professionals need to be CCLEAR: Climate collaborators, leaders, educators, advocates, and researchers
- Author
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Alexander Simidchiev, John S. Torday, Courtney Howard, Ilyssa O. Gordon, Ruth A. Etzel, Barbara C. Erny, Renzo R Guinto, Attila J Hertelendy, Ying Zhang, James M. Shultz, Nicole Redvers, Marc Futernick, Marcalee Alexander, Lwando Maki, Ashwini R. Sehgal, Ann-Christine Duhaime, Andrew T. Olagunju, and Eva R. Parker
- Subjects
Health professionals ,business.industry ,Political science ,Meteorology. Climatology ,Public relations ,Public aspects of medicine ,RA1-1270 ,QC851-999 ,business - Published
- 2021
4. What is the point of databases of reviews for dermatology if all they compile is 'insufficient evidence'?
- Author
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Victoria Diba, Hywel C Williams, Robert P. Dellavalle, Lisa M. Schilling, and Eva R. Parker
- Subjects
Skin manifestations ,medicine.medical_specialty ,Evidence-Based Medicine ,Database ,Point (typography) ,business.industry ,Alternative medicine ,Dermatology ,computer.software_genre ,Databases, Bibliographic ,Review Literature as Topic ,Systematic review ,Clinical decision making ,Primary caregiver ,medicine ,Humans ,Medical diagnosis ,business ,computer - Abstract
Background The use of review databases for dermatology has been questioned because of the impression that these reviews frequently report finding insufficient evidence to guide therapeutic recommendations. Objective We sought to determine the number of review database entries most relevant to dermatology (addressing diseases with skin manifestations whereby a dermatologist may be the primary caregiver) and the percentage of these entries that report sufficient evidence to guide clinical decision making. Methods We conducted computerized searches and analysis of reviews in the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effectiveness. Database entries were categorized using the face value reports of the original reviewers as: (1) finding sufficient evidence to inform clinical decisions; (2) finding insufficient evidence; or (3) unable to classify with regard to degree of evidence found. Results Of all review database entries, 3% (54/1235 in Cochrane Database of Systematic Reviews and 65/2208 in the Database of Abstracts of Reviews of Effectiveness) were deemed relevant to dermatology. In all, 14 entries from the Database of Abstracts of Reviews of Effectiveness were in the process of being written and not available for further evaluation. Of the remaining entries, 40% (42/105) reported finding sufficient evidence. Of the 10 most common dermatologic diagnoses, 8 were addressed in 30% (31/105) of these reviews. Of entries addressing common dermatologic diagnoses, 32% (10/31) reported finding sufficient evidence. Conclusions Although few (3%) entries in review databases currently address dermatology topics, entries address many (8/10) of the top 10 dermatology diagnoses. Contrary to popular belief, a substantial number (40%) of such reviews report sufficient evidence to inform clinical decisions making.
- Published
- 2004
- Full Text
- View/download PDF
5. CUSP/p63 expression in basal cell carcinoma
- Author
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Lela A. Lee, Michelle Aszterbaum, Patrick Walsh, Lih-Jen Su, Kristi Penheiter, Eva R. Parker, Angela Marchbank, Robert P. Dellavalle, Ervin H. Epstein, Timothy B.E. Grayson, and James DeGregori
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Seborrheic keratosis ,Patched ,Pathology ,medicine.medical_specialty ,integumentary system ,medicine.diagnostic_test ,Basal Cell Nevus Syndrome ,Dermatology ,Biology ,Immunofluorescence ,medicine.disease ,Biochemistry ,stomatognathic system ,Nevus sebaceous ,cardiovascular system ,medicine ,biology.protein ,Cusp (anatomy) ,Basal cell carcinoma ,cardiovascular diseases ,Sonic hedgehog ,Molecular Biology - Abstract
Chronic ulcerative stomatitis protein (CUSP), the most abundant cutaneous isoform of p63, is a p53-related gene essential for epithelial development. CUSP lacks the N-terminal transactivation domain found on other p53 family members and has been shown to inhibit p53 function in vitro. In this study, biopsies of normal skin (21 of 21), benign neoplasms [seborrheic keratosis (3 of 3), acrochordon (2 of 3), and verruca plana (3 of 3)], and squamous cell carcinomas (SCC) (4 of 4) displayed strong nuclear CUSP immuno-reactivity in epidermal cells. In contrast few basal cell carcinomas (BCC) (7 of 27) and sebaceous nevi (1 of 2) displayed this pattern of CUSP immunoreactivity. Thus, biopsies of cutaneous conditions characterized by sonic hedgehog (SHH) pathway dysregulation were more than 86 times as likely to lack CUSP/p63 immunofluorescence as were other cutaneous samples. Adjacent normal-appearing skin from patients with basal cell nevus syndrome (BCNS) (2 of 3) also lacked CUSP immuno-staining. Lastly, a BCC arising in a patched heterozygous mouse also lacked CUSP immuno-staining. Because CUSP mRNA and protein were detected via Northern and Western analysis in BCC samples lacking CUSP immuno-staining, we sequenced the coding region of CUSP from two non-staining BCCs but found no mutations. Therefore, CUSP appears to be present, unmutated, and yet frequently undetectable by immunofluorescence in cutaneous lesions in both humans and mice that are associated with SHH pathway dysregulation (BCCs, BCNS, and nevus sebaceous).
- Published
- 2002
- Full Text
- View/download PDF
6. Localized cutaneous argyria: two case reports and clinicopathologic review
- Author
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Joey Price, Colt M. McClain, Jerrold L. Abraham, Sara M. Kantrow, Jason B. Robbins, and Eva R. Parker
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Male ,education.field_of_study ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Population ,Dermatology ,General Medicine ,Middle Aged ,medicine.disease ,Argyria ,Pathology and Forensic Medicine ,Diagnosis, Differential ,Nevus, Blue ,Microscopy, Electron, Scanning ,Medicine ,Humans ,Differential diagnosis ,education ,business ,Aged ,Electron Probe Microanalysis - Abstract
We report 2 cases of patients who presented with blue macules clinically suspicious for blue nevi. One patient had no documented history of trauma or silver exposure, and the other reported exposure to silver over 30 years ago. Microscopic examination revealed a dermal population of brown-black globules predominantly adhering to collagen fibers. In both cases, no melanocytic proliferation was identified by immunohistochemistry. Analysis of the skin biopsies with scanning electron microscopy and energy dispersive x-ray spectroscopy demonstrated the presence of silver and selenium. These findings were diagnostic of localized cutaneous argyria. Our case reports highlight the importance of including localized cutaneous argyria in the differential diagnosis of pigmented lesions.
- Published
- 2013
7. Youth Access Laws
- Author
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Alan K. Chen, Eric J. Hester, Robert P. Dellavalle, Nancy Cersonsky, Bragg Hemme, Diane L. Burkhardt, Eva R. Parker, and Lisa M. Schilling
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medicine.medical_specialty ,Government ,business.industry ,Public health ,media_common.quotation_subject ,Common law ,Dermatology ,General Medicine ,Legislation as Topic ,Statute ,State (polity) ,Law ,medicine ,Salon ,business ,Developed country ,media_common - Abstract
Objective To compare laws governing youth access to UV irradiation at indoor tanning facilities with laws governing youth access to tobacco. Design Tobacco and UV irradiation youth access laws were assessed via correspondence with public health offices and computerized legal searches of 6 industrialized nations with widely differing skin cancer incidence rates. Setting National, provincial, and state legal systems in Australia, Canada, France, New Zealand, the United Kingdom, and the United States. Participants Public health, legal, information science, and medical professionals and government and tanning industry representatives. Main Outcome Measures Statutes specifying age restrictions for the purchase of indoor tanning services or tobacco products. Results The 5 English-speaking countries with common law–based legal systems unilaterally prohibit youth access to tobacco but rarely limit youth access to UV irradiation from tanning salons. Only very limited regions in the United States and Canada prohibit youth access to indoor tanning facilities: Texas, Illinois, Wisconsin, and New Brunswick prohibit tanning salon use by minors younger than 13, 14, 16, and 18 years, respectively. In contrast, French law allows minors to purchase tobacco but prohibits those younger than 18 years from patronizing tanning salons. Conclusions Youth access laws governing indoor tanning display remarkable variety. Uniform indoor tanning youth access laws modeled on the example of tobacco youth access laws merit consideration.
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- 2003
- Full Text
- View/download PDF
8. CUSP/p63 expression in basal cell carcinoma
- Author
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Robert P, Dellavalle, Patrick, Walsh, Angela, Marchbank, Timothy E, Grayson, Lih-Jen, Su, Eva R, Parker, James, DeGregori, Kristi, Penheiter, Michelle, Aszterbaum, Ervin H, Epstein, and Lela A, Lee
- Subjects
Skin Neoplasms ,Tumor Suppressor Proteins ,Fluorescent Antibody Technique ,Membrane Proteins ,Basal Cell Nevus Syndrome ,Genes, p53 ,Phosphoproteins ,DNA-Binding Proteins ,Mice ,Carcinoma, Basal Cell ,Trans-Activators ,Animals ,Humans ,Genes, Tumor Suppressor ,RNA, Neoplasm ,Skin ,Transcription Factors - Abstract
Chronic ulcerative stomatitis protein (CUSP), the most abundant cutaneous isoform of p63, is a p53-related gene essential for epithelial development. CUSP lacks the N-terminal transactivation domain found on other p53 family members and has been shown to inhibit p53 function in vitro. In this study, biopsies of normal skin (21 of 21), benign neoplasms [seborrheic keratosis (3 of 3), acrochordon (2 of 3), and verruca plana (3 of 3)], and squamous cell carcinomas (SCC) (4 of 4) displayed strong nuclear CUSP immuno-reactivity in epidermal cells. In contrast few basal cell carcinomas (BCC) (7 of 27) and sebaceous nevi (1 of 2) displayed this pattern of CUSP immunoreactivity. Thus, biopsies of cutaneous conditions characterized by sonic hedgehog (SHH) pathway dysregulation were more than 86 times as likely to lack CUSP/p63 immunofluorescence as were other cutaneous samples. Adjacent normal-appearing skin from patients with basal cell nevus syndrome (BCNS) (2 of 3) also lacked CUSP immuno-staining. Lastly, a BCC arising in a patched heterozygous mouse also lacked CUSP immuno-staining. Because CUSP mRNA and protein were detected via Northern and Western analysis in BCC samples lacking CUSP immuno-staining, we sequenced the coding region of CUSP from two non-staining BCCs but found no mutations. Therefore, CUSP appears to be present, unmutated, and yet frequently undetectable by immunofluorescence in cutaneous lesions in both humans and mice that are associated with SHH pathway dysregulation (BCCs, BCNS, and nevus sebaceous).
- Published
- 2002
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