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Your search keyword '"Eva Muñoz-Conejero"' showing total 6 results
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6 results on '"Eva Muñoz-Conejero"'

1. Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis.

Author

Gloria Sanchez-Antolín, Carolina Almohalla-Alvarez, Pilar Bueno, Raquel Almansa, Verónica Iglesias, Lucia Rico, Alicia Ortega, Eva Muñoz-Conejero, Felix García-Pajares, and Jesus F Bermejo-Martin

Subjects
Medicine, Science
Abstract

The role of systemic immunity in the pathogenesis of cirrhosis is not fully understood. Analysis of transcriptomic profiles in blood is an easy approach to obtain a wide picture of immune response at the systemic level. We studied gene expression profiles in blood from thirty cirrhotic patients and compared them against those of eight healthy volunteers. Most of our patients were male [n = 21, 70%] in their middle ages [57.4 ± 6.8 yr]. Alcohol abuse was the most frequent cause of cirrhosis (n = 22, 73%). Eleven patients had hepatocellular carcinoma (36.7%). Eight patients suffered from hepatitis C virus infection (26.7%). We found a signature constituted by 3402 genes which were differentially expressed in patients compared to controls (2802 over-expressed and 600 under-expressed). Evaluation of this signature evidenced the existence of an active pro-fibrotic transcriptomic program in the cirrhotic patients, involving the [extra-cellular matrix (ECM)-receptor interaction] & [TGF-beta signaling] pathways along with the [Cell adhesion molecules] pathway. This program coexists with alterations in pathways participating in [Glycine, serine and threonine metabolism], [Phenylalanine metabolism], [Tyrosine metabolism], [ABC transporters], [Purine metabolism], [Arachidonic acid metabolism]. In consequence, our results evidence the co-existence in blood of a genomic program mediating pro-fibrotic mechanisms and metabolic alterations in advanced cirrhosis. Monitoring expression levels of the genes involved in these programs could be of interest for predicting / monitoring cirrhosis evolution. These genes could constitute therapeutic targets in this disease.

Published
2015
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2. Evaluation of the 2016 Infectious Diseases Society of America/American Thoracic Society Guideline Criteria for Risk of Multidrug-Resistant Pathogens in Patients with Hospital-acquired and Ventilator-associated Pneumonia in the ICU

Author

Adrian Ceccato, Antoni Torres, Gianluigi Li Bassi, Otavio T. Ranzani, Pervin Korkmaz Ekren, Eva Muñoz Conejero, Miquel Ferrer, and Michael S. Niederman

Subjects
Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 030106 microbiology, Drug resistance, Critical Care and Intensive Care Medicine, Risk Assessment, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Drug Resistance, Multiple, Bacterial, Pneumonia, Bacterial, medicine, Humans, In patient, Prospective Studies, Intensive care medicine, Societies, Medical, Cross Infection, business.industry, Ventilator-associated pneumonia, Pneumonia, Ventilator-Associated, Guideline, Middle Aged, medicine.disease, United States, Anti-Bacterial Agents, Multiple drug resistance, Intensive Care Units, Pneumonia, 030228 respiratory system, Practice Guidelines as Topic, Female, business, Risk assessment, Cohort study
Published
2018
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3. Participación de los canales de calcio y las mitocondrias en la proliferación de las células de músculo liso vascular

Author

Eva Muñoz Conejero, Villalobos Jorge, Carlos, Núñez Llorente, Lucía, Universidad de Valladolid. Facultad de Medicina, Villalobos Jorge, Carlos, dir., and Núñez Llorente, Lucía, dir.

Subjects
Músculos-Enfermedades, Mitosis, Calcio en el organismo, Antiinflamatorios no esteroideos, Mitocondrias
Abstract

La excesiva proliferación celular contribuye al desarrollo de enfermedades como la aterosclerosis y la restenosis. Los anti-inflamatorios no esteroideos (AINEs) inhiben esa excesiva proliferación independientemente de su actividad anti-inflamatoria. La entrada de Ca2+ operada por depósitos (SOCE) es importante en la proliferación de las células de músculo liso vascular (VSMCs), por lo que estudiamos los canales de Ca2+ de estas células y el efecto antiproliferativo de ciertos AINEs. Utilizando las técnicas de medida de Ca2+ citosólico y mitocondrial, registros electrofisiológicos, qRT-PCR y western-blotting realizamos nuestro estudio en células A10 y un cultivo primario de células de músculo liso de arteria coronaria humana. Los resultados obtenidos muestran que SOCE, y las mitocondrias, que modulan esta vía, son esenciales en la proliferación de las VSMCs. Además, los AINEs actúan directamente sobre las mitocondrias y consecuentemente sobre SOCE, explicando de esta forma su efecto antiproliferativo., Departamento de Bioquímica y Biología Molecular y Fisiología

Published
2019
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4. Reflections on breastfeeding from the perspective of feminism

Author

Rosa María Cárdaba García, Inés Cárdaba García, and Eva Muñoz Conejero

Subjects
Time Factors, Perspective (graphical), Breastfeeding, Social Support, Gender studies, General Medicine, Feminism, Object Attachment, Breast Feeding, Humans, Female, Sociology, Prejudice
Published
2019

6. Invasive Disease vs Urinary Antigen-Confirmed Pneumococcal Community-Acquired Pneumonia

Author

Albert Gabarrus, Eva Polverino, Rosario Menéndez, Antoni Torres, Eva Muñoz-Conejero, Adrian Ceccato, Jorge Puig de la Bella Casa, Isabel Cifuentes, Michael S. Niederman, Carolina Garcia-Vidal, Cristina Méndez, Catia Cilloniz, Rosanel Amaro, Elena Prina, and Universitat de Barcelona

Subjects
Lung Diseases, Male, diagnosis, medicine.medical_treatment, Bacteremia, Critical Care and Intensive Care Medicine, Chronic liver disease, medicine.disease_cause, Infeccions per pneumococs, Pneumònia adquirida a la comunitat, 0302 clinical medicine, Community-acquired pneumonia, Risk Factors, 030212 general & internal medicine, Prospective Studies, Liver Diseases, Acute Kidney Injury, Middle Aged, Community-Acquired Infections, Pneumococcal infections, Streptococcus pneumoniae, Pneumococcal pneumonia, urinary antigen test, Female, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Adolescent, Pneumococcal Infections, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Risk factor, Mortality, Intensive care medicine, burden of pneumococcal disease, Aged, Mechanical ventilation, Antigens, Bacterial, business.industry, Pneumonia, Pneumococcal, medicine.disease, Respiration, Artificial, Pneumonia, 030228 respiratory system, Blood Culture, Spain, Chronic Disease, business
Abstract

BACKGROUND: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT results. METHODS: A prospective observational study of consecutive nonimmunosuppressed patients with community-acquired pneumonia was performed from January 2000 to December 2014. Patients were stratified into two groups: invasive pneumococcal pneumonia (IPP) defined as a positive blood culture or pleural fluid culture result and noninvasive pneumococcal pneumonia (NIPP) defined as a positive UAT result with negative blood or pleural fluid culture result. RESULTS: We analyzed 779 patients (15%) of 5,132, where 361 (46%) had IPP and 418 (54%) had NIPP. Compared with the patients with IPP, those with NIPP presented more frequent chronic pulmonary disease and received previous antibiotics more frequently. Patients with IPP presented more severe community-acquired pneumonia, higher levels of inflammatory markers, and worse oxygenation at admission; more pulmonary complications; greater extrapulmonary complications; longer time to clinical stability; and longer length of hospital stay compared with the NIPP group. Age, chronic liver disease, mechanical ventilation, and acute renal failure were independent risk factors for 30-day crude mortality. Neither IPP nor NIPP was an independent risk factor for 30-day mortality. CONCLUSIONS: A high percentage of confirmed pneumococcal pneumonia is diagnosed by UAT. Despite differences in clinical characteristics and outcomes, IPP is not an independent risk factor for 30-day mortality compared with NIPP, reinforcing the importance of NIPP for pneumococcal pneumonia.

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