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3. Broth microdilution protocol for determining antimicrobial susceptibility of Legionella pneumophila to clinically relevant antimicrobials

Author

Afzal, Amna, Allam, Camille, Amemura-Maekawa, Junko, Andersson, Sabina, Pérez, Elisenda Arqué, Astrid, Muyldermans, Bangsborg, Jette Marie, Bargellini, Annalisa, Barna, Zsófia, Beeton, Michael, Bigler, Mellina, Bošnjak, Selma, Brandsema, Petra, Brewin, Brett, Broger, Tobias, Brown, Derek, Coroneo, Valentina, Rotger, Sebastian Crespi, Cristino, Sandra, De Jong, Birgitta, Demuyser, Thomas, Doniselli, Nicola, Surman-Lee, Susanne, Elverdal, Pernille L., Erdogan, Haluk, Eriksen, Helle, Euser, Sjoerd, Fermi, Beatrice, Azcona, Juan Angel Ferrer, Franzin, Laura, Goldenberg, Simon, Gonçalves, Paulo, Fernandez, Tiscar Graells, Haider, Julia, Henderson, Kelley, Ibranosyan, Marine, Joergensen, Charlotte Svaerke, Jomidava, Tinatin, Jovanovic, Milica, Jowitt, Maddy, Katsemi, Evdokia, Keynan, Yoav, Kieper, Laurine, Kindingstad, Louise, Kozak-Muiznieks, Natalia, Kunwar, Digbijay, Kura, Fumiaki, Kyritsi, Maria, Lee, John Vincent, Löhr, Iren Høyland, Majeska, Kristin, Mäusezahl, Daniel, Mendris, Michail, Michel, Charlotte, Moore, Ginny, Moretti, Marco, Mustermann, Maximilian Test, Naguthevar, Santhanam, Paduano, Stefania, Niño, Noemí Párraga, Pedro-Botet, Maria Luisa, Castro, Sonia Perez, Pissarides, Nicholas, Prevost, Michele, Reukers, Daphne, Robesyn, Emmanuel, Schönning, Caroline, Simone, Graf, Stuart, Adam, Templeton, Kate, Topalli, Claudia, Uhle, Sarah, Uldum, Søren, Van Honacker, Eveline, Veschetti, Enrico, Walker, Jimmy, Wallet, France, Wasserstrom, Lisa, Whapham, Catherine, Wybo, Ingrid, Zoued, Abdelrahim, Sewell, Max, Farley, Caitlin, Portal, Edward A.R., Lindsay, Diane, Ricci, Maria Luisa, Jarraud, Sophie, Scaturro, Maria, Descours, Ghislaine, Krøvel, Anne Vatland, Barton, Rachael, Boostom, Ian, Ure, Roisin, Kese, Darja, Gaia, Valeria, Golob, Matej, Paukner, Susanne, Ginevra, Christophe, Afshar, Baharak, Nadarajah, Sendurann, Echahdi, Fedoua, González-Rubio, Juana María, González-Camacho, Fernando, Mentasti, Massimo, Flountzi, Anastasia S., Petzold, Markus, Moran-Gilad, Jacob, Winchell, Jonas, Wooton, Mandy, Bernard, Kathryn, Jones, Lucy C., Chalker, Victoria J., and Spiller, Owen B.

Published
2025
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4. Age-specific SARS-CoV-2 transmission differed from human rhinovirus in households during the early COVID-19 pandemic

Author

Boom, Trisja T., de Hoog, Marieke L.A., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D., Fourie, Elandri, Sluiter-Post, Judith G.C., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A.M., Eggink, Dirk, Reusken, Chantal, Bont, Louis J., Wildenbeest, Joanne G., van Houten, Marlies A., Duijts, Liesbeth, and Bruijning-Verhagen, Patricia C.J.L.

Published
2024
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8. UV-light fluorescence as a confirmation method for presumptive Legionella colonies isolated from water samples.

Author

Badoux, Paul, Atsma, Adrie, van Harmelen-Vrins, Esther, and Euser, Sjoerd

Subjects
NUCLEOTIDE sequencing, LEGIONNAIRES' disease, LEGIONELLA pneumophila, WATER sampling, LEGIONELLA, MATRIX-assisted laser desorption-ionization
Abstract

Legionnaires' disease (LD) is a severe and potentially fatal form of bacterial pneumonia caused by Legionella spp. We evaluated the use of UV-light for detecting Legionella non- pneumophila in water samples according to the NEN-EN-ISO 11731:2017 methodology (reference method) in a collaborative effort involving 10 laboratories. First, a test panel was constructed of 298 strains: 157 Legionella strains and 141 non- Legionella strains were cultured on buffered charcoal yeast extract (BCYE)-medium and confirmed according to ISO 11731: 2017 (cultured on BCYE agar plates with and without l -cysteine), and by matrix-assisted laser desorption-ionization time of flight or next generation sequencing. All strains were additionally exposed to an UV-light to assess if they showed a bright blue fluorescence effect (UV-positive) or not (UV-negative). Second, in an interlaboratory study, 10 laboratories analyzed a blinded set of 16 Legionella strains and 8 non- Legionella strains using both methods. The test panel analyses showed 100% accordance between the UV-light and reference method. In addition, the interlaboratory study results showed full agreement between both methods. Our results support the implementation of UV-light detection to confirm Legionella presumptive colonies during analyses of water samples according to the NEN-EN-ISO 11731:2017 methodology. Implementation of UV-light confirmation could reduce workload, time-to-result and costs for the analyses of water samples for the presence of Legionella. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Age-specific SARS-CoV-2 transmission differed from human rhinovirus in households during the early COVID-19 pandemic

Author

Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Onderzoek, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Boom, Trisja T, de Hoog, Marieke L A, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D, Fourie, Elandri, Sluiter-Post, Judith G C, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A M, Eggink, Dirk, Reusken, Chantal, Bont, Louis J, Wildenbeest, Joanne G, van Houten, Marlies A, Duijts, Liesbeth, Bruijning-Verhagen, Patricia C J L, Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Onderzoek, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Boom, Trisja T, de Hoog, Marieke L A, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D, Fourie, Elandri, Sluiter-Post, Judith G C, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A M, Eggink, Dirk, Reusken, Chantal, Bont, Louis J, Wildenbeest, Joanne G, van Houten, Marlies A, Duijts, Liesbeth, and Bruijning-Verhagen, Patricia C J L

Published
2024

10. Increased incidence of Mycoplasma pneumoniae infections and hospital admissions in the Netherlands, November to December 2023

Author

Bolluyt, Dita C., Euser, Sjoerd M., Souverein, Dennis, van Rossum, Annemarie Mc, Kalpoe, Jayant, van Westreenen, Mireille, Goeijenbier, Marco, Snijders, Dominic, Eggink, Dirk, Jongenotter, Femke, van Lelyveld, Steven Fl, van Houten, Marlies A., Bolluyt, Dita C., Euser, Sjoerd M., Souverein, Dennis, van Rossum, Annemarie Mc, Kalpoe, Jayant, van Westreenen, Mireille, Goeijenbier, Marco, Snijders, Dominic, Eggink, Dirk, Jongenotter, Femke, van Lelyveld, Steven Fl, and van Houten, Marlies A.

Abstract

Mycoplasma pneumoniae is an important cause of pneumonia and extra-pulmonary manifestations. We observed a rise in admissions due to M. pneumoniae infections starting October 2023 in a regional hospital in the Netherlands and an increased incidence in national surveillance data. The incidence in the Netherlands has not been that high since 2011. The patients had a lower median age compared with 2019 and 2020 (28 vs 40 years). M. pneumoniae should be considered in patients with respiratory symptoms, especially children.

Published
2024

11. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

Van Boven, Michiel, van Dorp, Christiaan H., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J., Kretzschmar, Mirjam E., Bruijning-Verhagen, Patricia, Van Boven, Michiel, van Dorp, Christiaan H., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J., Kretzschmar, Mirjam E., and Bruijning-Verhagen, Patricia

Abstract

Household studies provide an efficient means to study transmission of infectious diseases, enabling estimation of susceptibility and infectivity by person-type. A main inclusion criterion in such studies is usually the presence of an infected person. This precludes estimation of the hazards of pathogen introduction into the household. Here we estimate age- and time-dependent household introduction hazards together with within household transmission rates using data from a prospective household-based study in the Netherlands. A total of 307 households containing 1, 209 persons were included from August 2020 until March 2021. Follow-up of households took place between August 2020 and August 2021 with maximal follow-up per household mostly limited to 161 days. Almost 1 out of 5 households (59/307) had evidence of an introduction of SARS-CoV-2. We estimate introduction hazards and within-household transmission rates in our study population with penalized splines and stochastic epidemic models, respectively. The estimated hazard of introduction of SARS-CoV-2 in the households was lower for children (0-12 years) than for adults (relative hazard: 0.62; 95%CrI: 0.34-1.0). Estimated introduction hazards peaked in mid October 2020, mid December 2020, and mid April 2021, preceding peaks in hospital admissions by 1-2 weeks. Best fitting transmission models included increased infectivity of children relative to adults and adolescents, such that the estimated child-to-child transmission probability (0.62; 95%CrI: 0.40-0.81) was considerably higher than the adult-to-adult transmission probability (0.12; 95%CrI: 0.057-0.19). Scenario analyses indicate that vaccination of adults can strongly reduce household infection attack rates and that adding adolescent vaccination offers limited added benefit.

Published
2024

12. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, Bruijning-Verhagen, Patricia, Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, and Bruijning-Verhagen, Patricia

Published
2024

18. Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands

Author

Loenenbach, Anna D., Beulens, Christian, Euser, Sjoerd M., van Leuken, Jeroen P.G., Bom, Ben, van der Hoek, Wim, de Roda Husman, Ana Maria, Ruijs, Wilhelmina L.M., Bartels, Alvin A., Rietveld, Ariene, Boer, Jeroen W. den, and Brandsema, Petra S.

Subjects
Legionnaires' disease -- Genetic aspects -- Risk factors, Sewage treatment -- Usage, Health
Abstract

In autumn 2016, six reported cases of Legionnaires' disease (LD) were linked to the town of Boxtel, the Netherlands. In the second half of 2017, eight more cases were identified [...]

Published
2018
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19. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

van Boven, Michiel, primary, van Dorp, Christiaan H., additional, Westerhof, Ilse, additional, Jaddoe, Vincent, additional, Heuvelman, Valerie, additional, Duijts, Liesbeth, additional, Fourie, Elandri, additional, Sluiter-Post, Judith, additional, van Houten, Marlies A., additional, Badoux, Paul, additional, Euser, Sjoerd, additional, Herpers, Bjorn, additional, Eggink, Dirk, additional, Boom, Trisja, additional, Wildenbeest, Joanne, additional, Bont, Louis, additional, Rozhnova, Ganna, additional, Bonten, Marc J., additional, Kretzschmar, Mirjam E., additional, and Bruijning-Verhagen, Patricia, additional

Published
2023
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22. The impact of variant and vaccination on SARS-CoV-2 symptomatology:three prospective household cohorts

Author

Westerhof, Ilse, de Hoog, Marieke, Ieven, Margareta, Lammens, Christine, van Beek, Janko, Rozhnova, Ganna, Eggink, Dirk, Euser, Sjoerd, Wildenbeest, Joanne, Duijts, Liesbeth, van Houten, Marlies, Goossens, Herman, Giaquinto, Carlo, Bruijning‑Verhagen, Patricia, Westerhof, Ilse, de Hoog, Marieke, Ieven, Margareta, Lammens, Christine, van Beek, Janko, Rozhnova, Ganna, Eggink, Dirk, Euser, Sjoerd, Wildenbeest, Joanne, Duijts, Liesbeth, van Houten, Marlies, Goossens, Herman, Giaquinto, Carlo, and Bruijning‑Verhagen, Patricia

Abstract

Objectives: We compared age-stratified SARS-CoV-2 symptomatology of wild-type/Alpha vs Omicron BA.1/BA.2 variant infected individuals and the impact of COVID-19 booster vaccination on Omicron symptom burden. Methods: Data from three European prospective household cohorts were used (April 2020 to April 2021 and January to March 2022). Standardized outbreak protocols included (repeated) polymerase chain reaction testing, paired serology, and daily symptom scoring for all household members. Comparative analyses were performed on 346 secondary household cases from both periods. Results: Children <12 years (all unvaccinated) experienced more symptoms and higher severity scores during Omicron compared with wild-type/Alpha period (P ≤0.01). In adults, Omicron disease duration and severity were reduced (P ≤ 0.095). Omicron was associated with lower odds for loss of smell or taste (adjusted odds ratio [aOR]: 0.14; 95% CI 0.03-0.50) and higher but non-significant odds for upper respiratory symptoms, fever, and fatigue (aORs: 1.85-2.23). No differences were observed in disease severity or duration between primary vs booster series vaccinated adults (P ≥0.12). Conclusion: The Omicron variant causes higher symptom burden in children compared with wild-type/Alpha and lower in adults, possibly due to previous vaccination. A shift in symptoms occurred with reduction in loss of smell/taste for Omicron. No additional effect of booster vaccination on Omicron symptom burden was observed.

Published
2023

23. The impact of variant and vaccination on SARS-CoV-2 symptomatology; three prospective household cohorts

Author

Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Epi Infectieziekten Team 2, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Westerhof, Ilse, de Hoog, Marieke, Ieven, Margareta, Lammens, Christine, van Beek, Janko, Rozhnova, Ganna, Eggink, Dirk, Euser, Sjoerd, Wildenbeest, Joanne, Duijts, Liesbeth, van Houten, Marlies, Goossens, Herman, Giaquinto, Carlo, Bruijning-Verhagen, Patricia, Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Epi Infectieziekten Team 2, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Westerhof, Ilse, de Hoog, Marieke, Ieven, Margareta, Lammens, Christine, van Beek, Janko, Rozhnova, Ganna, Eggink, Dirk, Euser, Sjoerd, Wildenbeest, Joanne, Duijts, Liesbeth, van Houten, Marlies, Goossens, Herman, Giaquinto, Carlo, and Bruijning-Verhagen, Patricia

Published
2023

24. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Immuno/reuma patientenzorg, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, Bruijning-Verhagen, Patricia, Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Immuno/reuma patientenzorg, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, and Bruijning-Verhagen, Patricia

Published
2023

25. Longitudinal dynamics ofStreptococcus pneumoniaecarriage and SARS-CoV-2 infection in households with children

Author

Miellet, Willem R., primary, Mariman, Rob, additional, Eggink, Dirk, additional, Nicolaie, Mioara A., additional, van Veldhuizen, Janieke, additional, Pluister, Gerlinde, additional, Kolodziej, Lisa M., additional, van Lelyveld, Steven F.L., additional, Euser, Sjoerd M., additional, Sanders, Elisabeth A.M., additional, van Houten, Marianne A., additional, and Trzciński, Krzysztof, additional

Published
2023
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29. Efficacy and safety of revisional treatments for weight regain or insufficient weight loss after Roux‐en‐Y gastric bypass: A systematic review and meta‐analysis.

Author

Franken, Rutger J., Franken, Josephine, Sluiter, Nina R., de Vries, Ralph, Euser, Sjoerd, Gerdes, Victor E. A., and de Brauw, Maurits

Subjects
WEIGHT loss, GASTRIC bypass, GASTRIC banding, REOPERATION, RANDOM effects model
Abstract

Summary: Weight regain or inadequate weight loss following Roux‐en‐Y gastric bypass poses a significant clinical challenge. Our objective was to evaluate various revisional techniques for addressing weight regain and insufficient weight loss after Roux‐en‐Y gastric bypass through a systematic review and meta‐analysis. We performed a literature search (in PubMed and Embase) on revisional interventions in collaboration with a medical information specialist. Measured outcomes included body mass index at intervention, total weight loss during follow‐up, and complications. Random effects models were used to determine pooled effect size and corresponding 95% confidence intervals. Thirty‐nine studies were included: four studies reported on argon plasma coagulation, four studies on transoral outlet reduction, nine studies on transoral outlet reduction + argon plasma coagulation, four studies on pouch/gastrojejunal anastomosis revision, five on laparoscopic gastric banding, two studies on laparoscopic gastric banding + pouch resizing, 10 on distalization‐RYGB, and one on duodenal switch. All techniques resulted in short‐term clinically relevant weight loss. Endoscopic procedures had a short follow‐up and resulted in modest and temporary weight loss. Surgical revision techniques were successful for weight loss in longer term follow‐up, at the expense of high complication rates. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Longitudinal Household Assessment of Respiratory Illness in Children and Parents During the COVID-19 Pandemic

Author

de Hoog, Marieke L A, Sluiter-Post, Judith G C, Westerhof, Ilse, Fourie, Elandri, Heuvelman, Valerie D, Boom, Trisja T, Euser, Sjoerd M, Badoux, Paul, Reusken, Chantal, Bont, Louis J, Sanders, Elisabeth A M, Jaddoe, Vincent W V, Herpers, Bjorn L, Eggink, Dirk, Wildenbeest, Joanne G, Duijts, Liesbeth, van Houten, Marlies A, Bruijning-Verhagen, Patricia C J L, Medical Microbiology and Infection Prevention, AII - Infectious diseases, and Pediatrics

Subjects
Adult, Parents, Male, COVID-19 Vaccines, Adolescent, SARS-CoV-2, COVID-19, General Medicine, Cohort Studies, COVID-19 Testing, SDG 3 - Good Health and Well-being, Seroepidemiologic Studies, Humans, Female, Child, Pandemics
Abstract

ImportanceIn the early COVID-19 pandemic, SARS-CoV-2 testing was only accessible and recommended for symptomatic persons or adults. This restriction hampered assessment of the true incidence of SARS-CoV-2 infection in children as well as detailed characterization of the SARS-CoV-2 disease spectrum and how this spectrum compared with that of other common respiratory illnesses.ObjectiveTo estimate the community incidence of SARS-CoV-2 infection in children and parents and to assess the symptoms and symptom severity of respiratory illness episodes involving SARS-CoV-2–positive test results relative to those with SARS-CoV-2–negative test results.Design, Setting, and ParticipantsThis cohort study randomly selected Dutch households with at least 1 child younger than 18 years. A total of 1209 children and adults from 307 households were prospectively followed up between August 25, 2020, and July 29, 2021, covering the second and third waves of the COVID-19 pandemic. Participation included SARS-CoV-2 screening at 4- to 6-week intervals during the first 23 weeks of participation (core study period; August 25, 2020, to July 29, 2021). Participants in all households finishing the core study before July 1, 2021, were invited to participate in the extended follow-up and to actively report respiratory symptoms using an interactive app until July 1, 2021. At new onset of respiratory symptoms or a SARS-CoV-2 positive test result, a household outbreak study was initiated, which included daily symptom recording, repeated polymerase chain reaction testing (nose-throat swabs and saliva and fecal samples), and SARS-CoV-2 antibody measurement (paired dried blood spots) in all household members. Outbreaks, households, and episodes of respiratory illness were described as positive or negative depending on SARS-CoV-2 test results. Data on participant race and ethnicity were not reported because they were not uniformly collected in the original cohorts and were therefore not representative or informative.ExposuresSARS-CoV-2–positive and SARS-CoV-2–negative respiratory illness episodes.Main Outcomes and MeasuresAge-stratified incidence rates, symptoms, and symptom severity for SARS-CoV-2–positive and SARS-CoV-2–negative respiratory illness episodes.ResultsAmong 307 households including 1209 participants (638 female [52.8%]; 403 [33.3%] aged P Conclusions and RelevanceIn this cohort study, during the first pandemic year when mostly partial or full in-person learning occurred, the SARS-CoV-2 incidence rate in children was substantially higher than estimated from routine testing or seroprevalence data and was similar to that of adult household members. Unlike in unvaccinated adults, SARS-CoV-2 symptoms and symptom severity in children were similar to other common respiratory illnesses. These findings may prove useful when developing pediatric COVID-19 vaccine recommendations.

Published
2022

31. Symptom presentation among SARS-CoV-2 positive cases and the impact of COVID-19 vaccination; three prospective household cohorts

Author

Westerhof, Ilse, primary, de Hoog, Marieke, additional, Ieven, Margareta, additional, Lammens, Christine, additional, van Beek, Janko, additional, Rozhnova, Ganna, additional, Eggink, Dirk, additional, Euser, Sjoerd, additional, Wildenbeest, Joanne, additional, Duijts, Liesbeth, additional, van Houten, Marlies, additional, Goossens, Herman, additional, Giaquinto, Carlo, additional, and Bruijning-Verhagen, Patricia, additional

Published
2022
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34. Initial Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load Is Associated With Disease Severity: A Retrospective Cohort Study

Author

Souverein, Dennis, primary, van Stralen, Karlijn, additional, van Lelyveld, Steven, additional, van Gemeren, Claudia, additional, Haverkort, Milly, additional, Snijders, Dominic, additional, Soetekouw, Robin, additional, Kapteijns, Erik, additional, de Jong, Evelien, additional, Hermanides, Gonneke, additional, Aronson, Sem, additional, Herpers, Bjorn, additional, den Boer, Jeroen, additional, Wagemakers, Alex, additional, and Euser, Sjoerd, additional

Published
2022
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35. Longitudinal Household Assessment of Respiratory Illness in Children and Parents During the COVID-19 Pandemic

Author

de Hoog, Marieke L.A., Sluiter-Post, Judith G.C., Westerhof, Ilse, Fourie, Elandri, Heuvelman, Valerie D., Boom, Trisja T., Euser, Sjoerd M., Badoux, Paul, Reusken, Chantal, Bont, Louis J., Sanders, Elisabeth A.M., Jaddoe, Vincent W.V., Herpers, Bjorn L., Eggink, Dirk, Wildenbeest, Joanne G., Duijts, Liesbeth, van Houten, Marlies A., Bruijning-Verhagen, Patricia C.J.L., de Hoog, Marieke L.A., Sluiter-Post, Judith G.C., Westerhof, Ilse, Fourie, Elandri, Heuvelman, Valerie D., Boom, Trisja T., Euser, Sjoerd M., Badoux, Paul, Reusken, Chantal, Bont, Louis J., Sanders, Elisabeth A.M., Jaddoe, Vincent W.V., Herpers, Bjorn L., Eggink, Dirk, Wildenbeest, Joanne G., Duijts, Liesbeth, van Houten, Marlies A., and Bruijning-Verhagen, Patricia C.J.L.

Abstract

Importance: In the early COVID-19 pandemic, SARS-CoV-2 testing was only accessible and recommended for symptomatic persons or adults. This restriction hampered assessment of the true incidence of SARS-CoV-2 infection in children as well as detailed characterization of the SARS-CoV-2 disease spectrum and how this spectrum compared with that of other common respiratory illnesses. Objective: To estimate the community incidence of SARS-CoV-2 infection in children and parents and to assess the symptoms and symptom severity of respiratory illness episodes involving SARS-CoV-2-positive test results relative to those with SARS-CoV-2-negative test results. Design, Setting, and Participants: This cohort study randomly selected Dutch households with at least 1 child younger than 18 years. A total of 1209 children and adults from 307 households were prospectively followed up between August 25, 2020, and July 29, 2021, covering the second and third waves of the COVID-19 pandemic. Participation included SARS-CoV-2 screening at 4- to 6-week intervals during the first 23 weeks of participation (core study period; August 25, 2020, to July 29, 2021). Participants in all households finishing the core study before July 1, 2021, were invited to participate in the extended follow-up and to actively report respiratory symptoms using an interactive app until July 1, 2021. At new onset of respiratory symptoms or a SARS-CoV-2 positive test result, a household outbreak study was initiated, which included daily symptom recording, repeated polymerase chain reaction testing (nose-throat swabs and saliva and fecal samples), and SARS-CoV-2 antibody measurement (paired dried blood spots) in all household members. Outbreaks, households, and episodes of respiratory illness were described as positive or negative depending on SARS-CoV-2 test results. Data on participant race and ethnicity were not reported because they were not uniformly collected in the original cohorts and were therefore not repre

Published
2022

36. Longitudinal Household Assessment of Respiratory Illness in Children and Parents During the COVID-19 Pandemic

Author

Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Methodology, CTI Bont, Infectieziekten onderzoek1 (Bont), Onderzoek, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Immuno/reuma patientenzorg, JC onderzoeksprogramma Infectious Diseases, de Hoog, Marieke L.A., Sluiter-Post, Judith G.C., Westerhof, Ilse, Fourie, Elandri, Heuvelman, Valerie D., Boom, Trisja T., Euser, Sjoerd M., Badoux, Paul, Reusken, Chantal, Bont, Louis J., Sanders, Elisabeth A.M., Jaddoe, Vincent W.V., Herpers, Bjorn L., Eggink, Dirk, Wildenbeest, Joanne G., Duijts, Liesbeth, van Houten, Marlies A., Bruijning-Verhagen, Patricia C.J.L., Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Methodology, CTI Bont, Infectieziekten onderzoek1 (Bont), Onderzoek, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Immuno/reuma patientenzorg, JC onderzoeksprogramma Infectious Diseases, de Hoog, Marieke L.A., Sluiter-Post, Judith G.C., Westerhof, Ilse, Fourie, Elandri, Heuvelman, Valerie D., Boom, Trisja T., Euser, Sjoerd M., Badoux, Paul, Reusken, Chantal, Bont, Louis J., Sanders, Elisabeth A.M., Jaddoe, Vincent W.V., Herpers, Bjorn L., Eggink, Dirk, Wildenbeest, Joanne G., Duijts, Liesbeth, van Houten, Marlies A., and Bruijning-Verhagen, Patricia C.J.L.

Published
2022

38. High Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission Rates Detected by Dense Saliva Sampling

Author

Kolodziej, Lisa M, primary, van Lelyveld, Steven F L, additional, Haverkort, Mildred E, additional, Mariman, Rob, additional, Sluiter-Post, Judith G C, additional, Badoux, Paul, additional, de Koff, Emma M, additional, Koole, Jeffrey C D, additional, Miellet, Willem R, additional, Swart, Adriaan N, additional, Coipan, Elena C, additional, Meijer, Adam, additional, Sanders, Elisabeth A M, additional, Trzciński, Krzysztof, additional, Euser, Sjoerd M, additional, Eggink, Dirk, additional, and van Houten, Marianne A, additional

Published
2022
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39. The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study

Author

Euser, Sjoerd, primary, Weenink, Tieme, additional, Prins, Jan, additional, Haverkort, Milly, additional, Manders, Irene, additional, van Lelyveld, Steven, additional, Herpers, Bjorn, additional, Sinnige, Jan, additional, Kalpoe, Jayant, additional, Snijders, Dominic, additional, Cohen Stuart, James, additional, Slijkerman Megelink, Fred, additional, Kapteijns, Erik, additional, den Boer, Jeroen, additional, Wagemakers, Alex, additional, and Souverein, Dennis, additional

Published
2022
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41. High detection rate of viral pathogens in nasal discharge in children aged 0 till 5 years.

Author

Fourie, Elandri, Sijm, Yara E. E., Badoux, Paul, Mérelle, Marieke E., Haverkort, Mildred E., Euser, Sjoerd M., and van Houten, Marlies A.

Subjects
SARS-CoV-2, RESPIRATORY infections
Abstract

Respiratory tract infections (RTI) in children remain a cause of disease burden worldwide. Nasopharyngeal (NP) & oropharyngeal (OP) swabs are used for respiratory pathogen detection, but hold disadvantages particularly for children, highlighting the importance and preference for a child friendly detection method. We aimed to evaluate the performance and tolerability of a rhinorrhea swab (RS) in detecting viral pathogens when compared to a combined OP(/NP) or mid‐turbinate (MT) nasal swab. This study was conducted between September 2021 and July 2022 in the Netherlands. Children aged 0−5 years, with an upper RTI and nasal discharge, were included and received a combined swab and a RS. Multiplex polymerase chain reaction (PCR) and severe acute respiratory syndrome coronavirus‐2 PCR were used for viral pathogen detection. Tolerability was evaluated with a questionnaire and visual analog scale (VAS) scores. During 11 months 88 children were included, with a median age of 1.00 year [interquartile range 0.00−3.00]. In total 122 viral pathogens were detected in 81 children (92%). Sensitivity and specificity of the RS compared to a combined swab were respectively 97% (95% confidence interval [CI] 91%−100%) and 78% (95% CI 45%−94%). Rhinorrhea samples detected more pathogens than the (combined) nasal samples, 112 versus 108 respectively. Median VAS scores were significantly lower for the RS in both children (2 vs. 6) and their parents (0 vs. 5). A RS can therefore just as effectively/reliably detect viral pathogens as the combined swab in young children and is better tolerated by both children and their parents/caregivers. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Initial SARS-CoV-2 viral load is associated with disease severity: a retrospective cohort study

Author

Souverein, Dennis, primary, van Stralen, Karlijn, additional, van Lelyveld, Steven, additional, van Gemeren, Claudia, additional, Haverkort, Milly, additional, Snijders, Dominic, additional, Soetekouw, Robin, additional, Kapteijns, Erik, additional, de Jong, Evelien, additional, Hermanides, Gonneke, additional, Aronson, Sem, additional, Wagemakers, Alex, additional, and Euser, Sjoerd, additional

Published
2021
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43. SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study

Author

Euser, Sjoerd, primary, Aronson, Sem, additional, Manders, Irene, additional, van Lelyveld, Steven, additional, Herpers, Bjorn, additional, Sinnige, Jan, additional, Kalpoe, Jayant, additional, van Gemeren, Claudia, additional, Snijders, Dominic, additional, Jansen, Ruud, additional, Schuurmans Stekhoven, Sophie, additional, van Houten, Marlies, additional, Lede, Ivar, additional, Cohen Stuart, James, additional, Slijkerman Megelink, Fred, additional, Kapteijns, Erik, additional, den Boer, Jeroen, additional, Sanders, Elisabeth, additional, Wagemakers, Alex, additional, and Souverein, Dennis, additional

Published
2021
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45. Insulin/insulin-like growth factor-1 signaling and cognitive function in humans

Author

Euser, Sjoerd M., van Heemst, Diana, van Vliet, Peter, Breteler, Monique M.B., and Westendorp, Rudi G.J.

Subjects
Cognition -- Research, Insulin-like growth factor 1 -- Research, Health, Seniors
Abstract

An accumulating body of evidence suggests the involvement of an evolutionary conserved insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) pathway in the regulation of the life and health span in nematodes, flies, rodents, and humans. We studied the association between insulin/IGF-1 signaling and cognitive function among 1015 participants, 85 years old or older, of the population-based Leiden 85-Plus Study. A composite IIS6 score, based on expected effects (increased or decreased signaling) of selected variants in the IIS pathway, was calculated to estimate IIS pathway activity. Cognitive function was assessed at baseline and annually during a 5-year follow-up, using the Mini-Mental State Examination (MMSE). In women, but not in men, lower IIS6 scores (indicating decreased signaling) were associated with a lower risk of cognitive impairment (MMSE score [less than or equal to] 18) (p trend = .010). The IIS6 score was not associated with change in cognitive function. In addition to old age survival, genetically reduced IIS seems to be beneficial for cognitive function in women. Key Words: Insulin/IGF-1 signaling--Cognitive function--Cohort study--Human.

Published
2008

46. Respiratory Pathogen Detection in Children: Saliva as a Diagnostic Specimen

Author

Infectieziekten onderzoek3 (Bogaert), Infection & Immunity, Cluster B, Child Health, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, De Koff, Emma M., Euser, Sjoerd M., Badoux, Paul, Sluiter-Post, Judith, Eggink, Dirk, Sanders, Elisabeth A.M., Van Houten, Marlies A., Infectieziekten onderzoek3 (Bogaert), Infection & Immunity, Cluster B, Child Health, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, De Koff, Emma M., Euser, Sjoerd M., Badoux, Paul, Sluiter-Post, Judith, Eggink, Dirk, Sanders, Elisabeth A.M., and Van Houten, Marlies A.

Published
2021

48. High SARS-CoV-2 Household Transmission Rates Detected by Dense Saliva Sampling

Author

Kolodziej, Lisa Marie, primary, van Lelyveld, Steven FL, additional, Haverkort, Milly E., additional, Mariman, Rob, additional, Sluiter-Post, Judith GC, additional, Badoux, Paul, additional, de Koff, Emma M., additional, Koole, Jeffrey CD, additional, Miellet, Willem R., additional, Swart, Arno N., additional, Coipan, Elena Claudia, additional, Meijer, Adam, additional, Sanders, Elisabeth A.M., additional, Trzcinski, Krzysztof, additional, Euser, Sjoerd M., additional, Eggink, Dirk, additional, and van Houten, Marlies A., additional

Published
2021
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