15 results on '"Eun YS"'
Search Results
2. Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
- Author
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Shin MJ, Kim HS, Lee P, Yang NG, Kim JY, Eun YS, Lee W, Kim D, Lee Y, Jung KE, Hong D, Shin JM, Lee SH, Lee SY, Kim CD, and Kim JE
- Subjects
- Animals, Humans, Mice, Disease Models, Animal, Inflammation, NF-kappa B, Tumor Suppressor Proteins genetics, WW Domain-Containing Oxidoreductase genetics, Dermatitis, Psoriasis chemically induced, Psoriasis genetics
- Abstract
Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, aberrant differentiation of keratinocytes, and dysregulated immune responses. WW domain-containing oxidoreductase (WWOX) is a non-classical tumor suppressor gene that regulates multiple cellular processes, including proliferation, apoptosis, and migration. This study aimed to explore the possible role of WWOX in the pathogenesis of psoriasis. Immunohistochemical analysis showed that the expression of WWOX was increased in epidermal keratinocytes of both human psoriatic lesions and imiquimod-induced mice psoriatic model. Immortalized human epidermal keratinocytes were transduced with a recombinant adenovirus expressing microRNA specific for WWOX to downregulate its expression. Inflammatory responses were detected using Western blotting, real-time quantitative reverse transcription polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay. In human epidermal keratinocytes, WWOX knockdown reduced nuclear factor-kappa B signaling and levels of proinflammatory cytokines induced by polyinosinic: polycytidylic acid [(poly(I:C)] in vitro. Furthermore, calcium chelator and protein kinase C (PKC) inhibitors significantly reduced poly(I:C)-induced inflammatory reactions. WWOX plays a role in the inflammatory reaction of epidermal keratinocytes by regulating calcium and PKC signaling. Targeting WWOX could be a novel therapeutic approach for psoriasis in the future.
- Published
- 2023
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3. Relationships of Serum Homocysteine, Vitamin B 12 , and Folic Acid Levels with Papulopustular Rosacea Severity: A Case-Control Study.
- Author
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Chung BY, Kim HO, Park CW, Yang NG, Kim JY, Eun YS, Chung EH, Lee SY, Park YL, Lee SH, Heo NH, Shin MJ, and Kim JE
- Subjects
- Case-Control Studies, Folic Acid, Homocysteine, Humans, Vitamin B 12, Vitamins, Hyperhomocysteinemia etiology, Rosacea complications
- Abstract
Background: Rosacea is a chronic inflammatory skin disease with a multifactorial etiology. Recently, associations between serum homocysteine (Hcy) levels and inflammatory skin diseases, such as psoriasis and hidradenitis suppurativa, have been reported. However, no study has explored the levels of serum Hcy, folic acid, and vitamin B
12 in patients with rosacea., Objective: To investigate serum Hcy, vitamin B12 , and folic acid levels in patients with papulopustular rosacea (PPR), we characterized the association of these levels with PPR severity., Methods: This case-control study included 138 PPR patients and 58 healthy controls. The serum levels of Hcy, vitamin B12 , and folic acid were measured. A correlation was assessed between disease severity and serum levels of Hcy, vitamin B12 , and folic acid., Results: Serum vitamin B12 and folic acid levels were significantly lower in PPR patients than in the healthy controls ( p = 0.011 and p = 0.0173, respectively). Although serum Hcy levels did not significantly differ between PPR patients and healthy controls, PPR severity was positively correlated with serum Hcy levels ( p < 0.001)., Conclusions: Our results suggest a possible association between hyperhomocysteinemia and vitamin B12 deficiency in patients with PPR., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper., (Copyright © 2022 Bo Young Chung et al.)- Published
- 2022
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4. Nail lichen striatus: report of seven cases and review of the literature.
- Author
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Kim M, Jung HY, Eun YS, Cho BK, and Park HJ
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- Adrenal Cortex Hormones therapeutic use, Adult, Child, Child, Preschool, Drug Therapy, Combination, Female, Foot Dermatoses drug therapy, Hand Dermatoses drug therapy, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents therapeutic use, Lichenoid Eruptions drug therapy, Male, Nail Diseases drug therapy, Tacrolimus therapeutic use, Triamcinolone Acetonide therapeutic use, Foot Dermatoses pathology, Hand Dermatoses pathology, Lichenoid Eruptions pathology, Nail Diseases pathology
- Abstract
Background: Nail involvement in lichen striatus (LS) is rare and has not been documented extensively., Objectives: This study describes the clinical and histological features, response to treatment, and follow-up in seven patients with nail LS., Methods: We reviewed seven cases of nail LS between 2006 and 2012 at the Dermatology Department, Yeouido St Mary's Hospital, Seoul, South Korea., Results: The median patient age was 11 years (range: 4-33 years), and the female:male ratio was 3:4. All patients had both typical skin lesions and nail abnormalities. In these cases, LS usually involved a single digit (n = 5). The most common nail change was longitudinal fissuring (n = 4). We actively treated both skin and nail lesions from the time of diagnosis. Most nail lesions resolved within a mean of four months of the initiation of treatment., Conclusions: Nail involvement in LS is rare; this case series highlights the associated nail changes. We emphasize that early accurate diagnosis and treatment may be beneficial in reducing nail deformities in patients with nail involvement., (© 2015 The International Society of Dermatology.)
- Published
- 2015
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5. Subungual soft tissue chondroma with nail deformity in a child.
- Author
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Eun YS, Kim MR, Cho BK, Yoo G, and Park HJ
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- Child, Chondroma surgery, Female, Fingers, Humans, Nail Diseases surgery, Soft Tissue Neoplasms surgery, Chondroma diagnosis, Nail Diseases diagnosis, Soft Tissue Neoplasms diagnosis
- Abstract
Soft tissue chondroma is a rare benign tumor of the cartilage. It occurs commonly in distal extremities of middle-aged patients. It is usually asymptomatic and grows slowly, making early diagnosis difficult. We report a 10-year-old patient with a 1-year history of a subungual soft tissue chondroma on her left fifth finger. The lesion arose from nail bed and distal nail matrix, resulting in nail dystrophy. Magnetic resonance imaging revealed a soft tissue tumor in the subungual region and soft tissue chondroma was diagnosed, based on histopathologic findings. Dermatologists should consider soft tissue chondroma in the differential diagnosis of subungual tumors of children., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2015
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6. Expression of insulin-like growth factor-1 receptor in conventional cutaneous squamous cell carcinoma with different histological grades of differentiation.
- Author
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Oh ST, Eun YS, Yoo DS, Park HJ, Kim TY, Cho BK, Stark A, and Reichrath J
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- Humans, Immunohistochemistry, Neoplasm Grading, Receptor, IGF Type 1 analysis, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell pathology, Receptor, IGF Type 1 biosynthesis, Skin Neoplasms metabolism, Skin Neoplasms pathology
- Abstract
Background: Insulin-like growth factor-1 receptor (IGF-1R) is a key regulator of cell transformation and controls the expression of genes that governs cell cycling and cell survival. The aim of this pilot study was to gain insight into the expression pattern of IGF-1R in conventional cutaneous squamous cell carcinoma (CSCC) using immunohistochemical analysis., Materials and Methods: Five cases of normal human paraffin-embedded skin sections, 4 cases of actinic keratosis, and 28 cases of paraffin-embedded sections of different histological subtypes of CSCC were selected for immunohistochemical analysis., Results: In normal skin, IGF-1R expression was detected in the epidermal basal cell layer. In actinic keratosis, IGF-1R was expressed in the lower part of the epidermis. IGF-1R was detected in the cell surface membrane of well-differentiated CSCC. In moderately differentiated CSCC, IGF-1R was expressed predominantly in the cytoplasm. Interestingly, IGF-1R was expressed in the nuclei of tumor cells of poorly differentiated CSCC., Conclusions: The strong and differential expression of IGF-1R in different histological degrees of CSCC indicates a possible role for IGF-insulin receptor in the carcinogenesis and differentiation of this disease and identifies IGF-1R as an interesting target for prevention and treatment of CSCC that deserves further investigation.
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- 2014
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7. Effects of multi-polar radiofrequency and pulsed electromagnetic field treatment in Koreans: case series and survey study.
- Author
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Lee YB, Eun YS, Lee JH, Cheon MS, Cho BK, and Park HJ
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- Adult, Asian People, Electromagnetic Fields, Face, Female, Health Care Surveys, Humans, Male, Middle Aged, Patient Satisfaction, Rejuvenation, Magnetic Field Therapy, Radiofrequency Therapy, Skin radiation effects, Skin Aging radiation effects
- Abstract
Background: Recently, a novel combined multi-polar radiofrequency and pulsed electromagnetic field device was developed for non-ablative skin tightening. However, little is known about the clinical effects of this device., Objectives: The present study evaluated the clinical efficacy and safety of the multi-polar radiofrequency and pulsed electromagnetic field device., Materials and Methods: Ten Korean patients underwent eight treatment sessions over 6 weeks. Clinical photographs of the skin were taken before and after the treatment at each week of treatment. Satisfaction score (0; dissatisfied, 5; neutral, 10; very satisfied) and pain score (0; no pain, 10; too painful) was determined using weekly questionnaires. A dermatologist evaluated the improvement of facial skin aging, including laxity, nasolabial fold, facial contour, skin texture, and skin color tone., Results: The mean satisfaction score was high (>8) and the mean pain score was low (1.5). Improved skin laxity, nasolabial fold, and facial contour were observed in four, one, and three patients, respectively. Skin texture and skin color tone improved in 90% and 70% of the patients, respectively., Conclusion: The novel combined multi-polar radiofrequency and pulsed electromagnetic field device is safe and effective for rejuvenating aged skin in Korean subjects.
- Published
- 2014
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8. Periorbital lipogranuloma related to filler migration: a rare complication of facial fillers.
- Author
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Eun YS, Cho SH, Lee JD, and Kim HS
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- Aged, Female, Humans, Injections, Subcutaneous, Republic of Korea, Cosmetic Techniques adverse effects, Face, Granuloma etiology, Orbital Pseudotumor etiology, Postoperative Complications etiology
- Published
- 2014
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9. A woman with a nose like an "Elephant's Trunk".
- Author
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Eun YS, Cho SH, Lee JD, and Kim HS
- Subjects
- Female, Humans, Middle Aged, Republic of Korea, Cosmetic Techniques adverse effects, Granuloma etiology, Nose
- Abstract
For more than a century, exogenous lipids and injectable silicone have been used by nonmedical personnel or even licensed physicians to correct body defects and augment parts of the human body. Any skin-implanted exogenous substances can trigger an inflammatory response in individuals. Notably, oily substances have commonly been reported to produce a foreign body granulomatous reaction known as "sclerosing lipogranuloma". Despite local and systemic complications, injections of illegal materials by unlicensed practitioners are widespread and are still a problem throughout East Asian Countries. We herein present a unique case of sclerosing lipogranuloma following illegal filler injection.
- Published
- 2014
- Full Text
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10. Clinical characteristics of cholinergic urticaria in Korea.
- Author
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Kim JE, Eun YS, Park YM, Park HJ, Yu DS, Kang H, Cho SH, Park CJ, Kim SY, and Lee JY
- Abstract
Background: Cholinergic urticaria is a type of physical urticaria characterized by heat-associated wheals. Several reports are available about cholinergic urticaria; however, the clinical manifestations and pathogenesis are incompletely understood., Objective: The purpose of this study was to investigate the clinical characteristics of cholinergic urticaria in Korea., Methods: We performed a retrospective study of 92 patients with cholinergic urticaria who were contacted by phone and whose diagnoses were confirmed by the exercise provocation test among those who had visited The Catholic University of Korea, Catholic Medical Center from January 2001 to November 2010., Results: All 92 patients were male, and their average age was 27.8 years (range, 17~51 years). Most of the patients had onset of the disease in their 20s and 30s. Non-follicular wheals were located on the trunk and upper extremities of many patients, and the symptoms were aggravated by exercise. Eight patients showed general urticaria symptoms and 15 had accompanying atopic disease. Forty-three patients complained of seasonal aggravation. Most patients were treated with first and second-generation antihistamines., Conclusion: Dermatologists should consider these characteristics in patients with cholinergic urticaria. Further investigation and follow-up studies are necessary to better understand the epidemiological and clinical findings of cholinergic urticaria.
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- 2014
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11. Elkonyxis in association with washboard nail and 20-nail dystrophy.
- Author
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Lee YB, Cheon MS, Eun YS, Park HJ, and Cho BK
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- Aged, Angiolymphoid Hyperplasia with Eosinophilia complications, Biopsy, Female, Humans, Male, Nail Diseases etiology, Angiolymphoid Hyperplasia with Eosinophilia pathology, Nail Diseases pathology, Nails injuries, Nails pathology
- Published
- 2014
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12. Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: a pilot study.
- Author
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Lee YB, Eun YS, Lee JH, Cheon MS, Park YG, Cho BK, and Park HJ
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- Administration, Topical, Adult, Carrier Proteins administration & dosage, Drug Combinations, Female, Fibroblast Growth Factor 10 administration & dosage, Fibroblast Growth Factor 2 administration & dosage, Humans, Insulin-Like Growth Factor I administration & dosage, Pilot Projects, Stem Cell Factor administration & dosage, Superoxide Dismutase administration & dosage, Superoxide Dismutase-1, Vascular Endothelial Growth Factor A administration & dosage, Alopecia therapy, Hair growth & development, Intercellular Signaling Peptides and Proteins administration & dosage, Needles statistics & numerical data, Punctures methods
- Published
- 2013
- Full Text
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13. Cyclosporin administration improves clinical manifestations and quality of life in patients with 20-nail dystrophy: case series and survey study.
- Author
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Lee YB, Cheon MS, Eun YS, Cho BK, Park YG, and Park HJ
- Subjects
- Adolescent, Adult, Aged, Cyclosporine administration & dosage, Dermatologic Agents administration & dosage, Female, Humans, Male, Middle Aged, Young Adult, Cyclosporine therapeutic use, Dermatologic Agents therapeutic use, Nail Diseases drug therapy, Nails, Malformed drug therapy
- Published
- 2012
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14. Effects of long-pulsed 1,064-nm neodymium-doped yttrium aluminum garnet laser on dermal collagen remodeling in hairless mice.
- Author
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Lee YB, Kang NH, Eun YS, Cheon MS, Kim KM, Cho BK, and Park HJ
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- Animals, Collagen metabolism, Male, Matrix Metalloproteinase 1 genetics, Matrix Metalloproteinase 1 metabolism, Mice, Mice, Hairless, Models, Animal, RNA, Messenger metabolism, Rejuvenation, Skin metabolism, Skin pathology, Skin Aging pathology, Tissue Inhibitor of Metalloproteinase-1 genetics, Tissue Inhibitor of Metalloproteinase-1 metabolism, Transforming Growth Factor beta genetics, Transforming Growth Factor beta metabolism, Ultraviolet Rays adverse effects, Collagen radiation effects, Lasers, Semiconductor therapeutic use, Skin radiation effects, Skin Aging radiation effects
- Abstract
Background: Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown., Objective: To investigate the effects of energy fluences of the long-pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) nonablative laser on dermal collagen remodeling and evaluate the dermal collagen remodeling mechanism., Materials and Methods: Hairless mice were pretreated with ultraviolet B irradiation to produce photo-damage. The laser treatment used a long-pulse 1,064-nm Nd:YAG laser at energy fluences of 20, 40, and 60 J/cm(2) . The amount of dermal collagen and expressions of transforming growth factor beta (TGF-β), matrix metalloproteinase-1 (MMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) of laser treated skin were compared with those of nontreated control skin., Results: The long-pulse Nd:YAG laser treatment increased dermal collagen and significantly increased TGF-β expression. The expression of MMP-1 decreased with low energy fluence. The expression of TIMP-1 was not significantly different., Conclusion: Long-pulsed 1,064-nm Nd:YAG laser increases the dermal collagen in association with the increased expression of TGF-β., (© 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.)
- Published
- 2012
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15. Erythroid differentiation regulator 1 (Erdr1) is a proapototic factor in human keratinocytes.
- Author
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Kim HJ, Song SB, Yang Y, Eun YS, Cho BK, Park HJ, and Cho DH
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- Apoptosis radiation effects, Apoptosis Regulatory Proteins antagonists & inhibitors, Apoptosis Regulatory Proteins genetics, Base Sequence, Caspase 3 metabolism, Cell Line, Gene Knockdown Techniques, Humans, Keratinocytes radiation effects, MAP Kinase Signaling System, RNA, Small Interfering genetics, Ultraviolet Rays adverse effects, Apoptosis physiology, Apoptosis Regulatory Proteins physiology, Keratinocytes cytology, Keratinocytes physiology
- Abstract
Skin is constantly exposed to physical and chemical stressors. The exposure of keratinocytes to ultraviolet B (UVB) irradiation causes epidermal damage via induction of apoptosis. Erythroid differentiation regulator 1 (Erdr1) modulates growth and survival of cells under various stressful conditions, but the function of Erdr1 in human keratinocyte apoptosis has not been investigated so far. Here, we investigated the effect of Erdr1 on UVB-induced apoptosis in human keratinocytes and also examined the underlying regulatory mechanism. First, Erdr1 expression was detected in human primary keratinocytes and normal human skin tissues. Expression of Erdr1 was enhanced in human keratinocytes following UVB irradiation. Knock-down of Erdr1 led to resistance to UVB-induced apoptosis. Also, Erdr1 overexpression increased UVB-induced apoptosis and induced caspase-3 activation. Furthermore, the extracellular signal-regulated kinase (ERK) inhibitor PD98059 and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 significantly reduced Erdr1 expression following UVB irradiation. These results indicate that UVB induces Erdr1 via a MAPK-dependent mechanism. Taken together, these findings suggest that Erdr1 has a role as a proapoptotic factor in human keratinocytes and acts via ERK and p38 MAPK pathways. Therefore, Erdr1 may be a potential therapeutic target to reduce apoptosis in keratinocytes in conditions such as psoriasis and skin cancer., (© 2011 John Wiley & Sons A/S.)
- Published
- 2011
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