1. Association between T1w/T2w ratio in white matter and cognitive function in Alzheimer’s disease
- Author
-
Sae-Nal Lee, Sung-Ho Woo, Eun Ja Lee, Kwang Ki Kim, and Hang-Rai Kim
- Subjects
Medicine ,Science - Abstract
Abstract Loss of myelin in the brain may lead to cognitive decline in Alzheimer's disease (AD). The ratio of T1 weighted/T2 weighted (T1w/T2w) on magnetic resonance imaging has been used as a proxy for myelin content in the brain. Using this approach, we investigated the correlation between the white matter (WM) T1w/T2w ratio and both cognitive scores and disease progression in AD. A total of 93 participants who were cognitively unimpaired or diagnosed with mild cognitive impairment or AD dementia were recruited between March 2021 and November 2022. All participants were assessed using neuropsychological tests, and a subset of the participants was assessed every 1 year to monitor disease progression. We observed significant positive associations between the WM T1w/T2w ratio and executive function within the fornix, sagittal stratum, anterior internal capsule, and body of the corpus callosum (False discovery rate [FDR]-corrected P-value
- Published
- 2024
- Full Text
- View/download PDF