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Cancerul endometrial, precum am demonstrat prin metode complexe moderne (aprecierea cantitativă a ARN-ului mesager, imunohistochimie, microscopie electronică), este o maladie în inițierea şi progresia căreia un rol deosebit le revine aminelor biogene, în special serotoninei şi sistemului serotoninergic. În 72% cazuri de cancer endometrial se apreciază o creştere semnificativă (de zeci de ori) a ARN-ului mesager pentru triptofanhidroxilaza 1, majoritatea cazurilor aparţinând clinic variantei patogenetice hormonal-dependente. În cazurile de nivel redus al ARN-ului mesager pentru triptofanhidroxilaza 1 este crescută frecvenţa variantei autonome, hormonal-independente de dezvoltare a cancerului endometrial. Adenocarcinoamele endometriale cu nivel sporit de ARN mesager pentru triptofanhidroxilaza 1 sunt, de regulă, bine diferenţiate, cu un nivel limitat de infiltrare a peretelui uterin, pe când carcinoamele cu nivel scăzut de ARN mesager pentru această enzimă manifestă particularităţi histologice care denotă comportament agresiv. Imunohistochimic se constată o corelaţie inversă dintre expresia receptorilor estrogenici şi nivelul de triptofanhidroxilază 1 în parenchimul carcinomului endometrial, însă nivelul receptorilor progesteronici corelează nesemnificativ cu expresia enzimei respective..

Cancerele endometrale se întâlnesc cu aceeaşi frecventă maximală în două decade: perioada 50-59 ani, care poate fi numită perimenopauzală, şi perioada 60-69 ani, cea postmenopauzală. Cancerul perimenopauzal, cum mărturisesc datele obţinute, poate avea ca precursori hiperplaziile endometrale, îndeosebi cele atipice, foarte frecvent însoţite de manifestări clinice dishormonale. Al doilea tip de cancer endometral, cel postmenopauzal, poate avea ca precursor numai hiperplaziile atipice care mai persistă în această perioadă, sau se dezvoltă intru-un endometru aparent atrofic. Tratamentul hormonal local cu relizing sistem „Mirena” poate fi apreciat ca o alternativă efectivă a tratamentului conservativ sistemic hormonal a stărilor precursore a cancerului endometrial, ce permite a exclude efectele secundare negative specifice pentru tratament cu progestine prolangate şi cu agonişti de relizing factori, folosite până în prezent.

Posture influences at work on the entire musculoskeletal apparatus, but with great consequences for the spine. Postural dentists use two totally different ways of working: seated working position and postural working position. The seating position is currently considered the ergonomic and postural is considered all unergonomic. This study aims to analyze the disco-vertebral and muscle pain, the conditions for carrying out or postural seating. The study was conducted on two groups A and B consisting of 43 random and that 47 dentists (49 women, 41 men), aged 30-55 years (maximum age of assets). The primary composition of the lots was the position taken during medical activity. Group A was selected for orthostatic position and group B seated on a wheelchair. In conclusion, there is an ideal working posture for the dentist, such as orthostatic position and sitting with the three types of support may be required for the backbone. Must always wanted workstations that causes less fatigue as being major change position after a period of time (maximum one hour).

Both posture and professional movement in a dental office are shaping the behaviour of the musculoskeletal system, particularly the spine. Two different postural methods are commonly used by dental practitioners, including sitting and standing postures. While sitting is considered as ergonomic, the standing position is considered non-ergonomic, with significant consequences on vertebral structures. Objectives: to realize a complex analysis of the disco-vertebral and muscular pathology in relation with either orthostatic or sitting posture in the real life dental practice. Materials and methods: prospective observational trial on 142 dentists classified into groups based on the predominant position during medical activity, either orthostatic or sitting on ergonomic chair. Results: there is no ideal working posture for the dentist; both orthostatic and sitting position with three subtypes (ischiatic, ischio-femoral, ischio-sacral support) result in significant spine morbidity, meaning an increased number of degenerative disco-vertebral pathology identified clinically (local or irradiated pain, restriction of mobility, impaired tolerance for standing position) and imagistic (X-rays, computed tomography, magnetic resonance imaging). Conclusion: It is widely promoted the recurrent alternation of posture in dental practice and an ergonomic attitude at the workplace. An individualized, strictly monitored kinetic activity is mandatory for both prevention and management of static and dynamic spine abnormalities due to repetitive postural stress in dental practice.

Background: Timely detection and aggressive management of interstitial lung disease (ILD) in systemic sclerosis (SSc) are essential to improving outcomes and reducing risks of irreversible lung injury. Objective: to explore the usefulness of an ultraportable ultrasound device for the management of SSc-related ILD and to compare it with clinical and instrumental data. Methods: A total of 19 consecutive SSc patients underwent a comprehensive pulmonary evaluation: clinical, pulmonary function tests (PFTs) (spirometry, DLCO), lung CT (1.5 mm slice thickness reconstruction; HRCT), and lung ultrasound (LUS). A total score was calculated based on the number of color-coded B-lines recorded for each lung sliding. B-lines were analyzed against dyspnea, cough, Velcro, CT imaging (Warrick’s score), and PFTs. Global and subgroup analysis were performed (diffuse versus limited cutaneous SSc, Warrick’s < 7 versus >7). Results: Symptomatic lung involvement with varying degrees of dyspnea was reported in about 74% of cases (functional NYHA > 2 in more than half), chronic dry cough in one-third, Velcro rales in 42%. A total of 84.24% were classified as SSc with ILD on CT imaging. Statistically significant mild-to-moderate correlations between B-lines and clinical manifestations were demonstrated, as well as PFTs and Warrick’s scores (more B-lines, lower pulmonary function, but higher extent and severity on CT) (p < 0.05); there were differences between SSc patients without and with ILD in terms of the number and distribution of B-lines (p < 0.05), as well as different B-lines patterns and numbers in diffuse versus limited SSc (p < 0.05). Conclusions: Ultraportable handheld LUS is a promising method suitable for the management (screening, early detection, and evaluation) of SSc patients.