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5 results on '"Ettel, J."'

1. In Reply: Xenon Myocardial Protection in Cardiac Surgery: Effective around the Clock?

Author

Hofland, J., Ouattara, A., Schaller, M., Bein, B., Liefde, I., Fellahi, J.L., Gruenewald, M., Hazebroucq, J., Ecoffey, C., Joseph, P., Heringlake, M., Steib, A., Coburn, M., Amour, J., Rozec, B., Meybohm, P., Preckel, B., Hanouz, J.L., Tritapepe, L., Tonner, P., Benhaoua, H., Roesner, J.P., Tenbrinck, R., Bogers, A.J.J.C., Mik, B.G., Coiffic, A., Renner, J., Steinfath, M., Francksen, H., Broch, O., Haneya, A., Guinet, P., Daviet, L., Brianchon, C., Rosier, S., Lehot, J.J., Paarmann, H., Schon, J., Hanke, T., Ettel, J., Olsson, S., Klotz, S., Samet, A., Laurinenas, G., Thibaud, A., Cristinar, M., Collanges, O., Levy, F., Rossaint, R., Stevanovic, A., Schaelte, G., Stoppe, C., Hamou, N.A., Hariri, S., Quessard, A., Carillion, A., Morin, H., Silleran, J., Robert, D., Crouzet, A.S., Zacharowski, K., Reyher, C., Iken, S., Weber, N.C., Hollmann, M., Eberl, S., Carriero, G., Collacchi, D., Persio, A. Di, Fourcade, O., Bergt, S., and Alms, A.

Subjects
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Item does not contain fulltext

Published
2018

2. Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial

Author

Hofland, J., Ouattara, A., Fellahi, J.L., Gruenewald, M., Hazebroucq, J., Ecoffey, C., Joseph, P., Heringlake, M., Steib, A., Coburn, M., Amour, J., Rozec, B., Liefde, I., Meybohm, P., Preckel, B., Hanouz, J.L., Tritapepe, L., Tonner, P., Benhaoua, H., Roesner, J.P., Bein, B., Hanouz, L., Tenbrinck, R., Bogers, A., Mik, B.G., Coiffic, A., Renner, J., Steinfath, M., Francksen, H., Broch, O., Haneya, A., Schaller, M., Guinet, P., Daviet, L., Brianchon, C., Rosier, S., Lehot, J.J., Paarmann, H., Schon, J., Hanke, T., Ettel, J., Olsson, S., Klotz, S., Samet, A., Laurinenas, G., Thibaud, A., Cristinar, M., Collanges, O., Levy, F., Rossaint, R., Stevanovic, A., Schaelte, G., Stoppe, C., Hamou, N.A., Hariri, S., Quessard, A., Carillion, A., Morin, H., Silleran, J., Robert, D., Crouzet, A.S., Zacharowski, K., Reyher, C., Iken, S., Weber, N.C., Hollmann, M., Eberl, S., Carriero, G., Collacchi, D., Persio, A. Di, Fourcade, O., Bergt, S., Alms, A., APH - Quality of Care, Anesthesiology, ANS - Neuroinfection & -inflammation, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Male, Methyl Ethers, inhalation, Internationality, Xenon, Troponin I, anesthesia, Middle Aged, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Sevoflurane, Postoperative Complications, Treatment Outcome, anesthetics, intravenous, Anesthetics, Inhalation, Anesthesia, Intravenous, Humans, Female, Single-Blind Method, Prospective Studies, aged, anesthetics, inhalation, biomarkers, coronary artery bypass, female, humans, male, methyl ethers, middle aged, postoperative complications, prospective studies, single-blind method, treatment outcome, troponin i, xenon, anesthesia, intravenous, internationality, Coronary Artery Bypass, Biomarkers, Aged
Abstract

Item does not contain fulltext BACKGROUND: Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models. METHODS: In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous anesthesia for anesthesia maintenance. The primary outcome was the cardiac troponin I concentration in the blood 24 h postsurgery. The noninferiority margin for the mean difference in cardiac troponin I release between the xenon and sevoflurane groups was less than 0.15 ng/ml. Secondary outcomes were the safety and feasibility of xenon anesthesia. RESULTS: The first patient included at each center received xenon anesthesia for practical reasons. For all other patients, anesthesia maintenance was randomized (intention-to-treat: n = 492; per-protocol/without major protocol deviation: n = 446). Median 24-h postoperative cardiac troponin I concentrations (ng/ml [interquartile range]) were 1.14 [0.76 to 2.10] with xenon, 1.30 [0.78 to 2.67] with sevoflurane, and 1.48 [0.94 to 2.78] with total intravenous anesthesia [per-protocol]). The mean difference in cardiac troponin I release between xenon and sevoflurane was -0.09 ng/ml (95% CI, -0.30 to 0.11; per-protocol: P = 0.02). Postoperative cardiac troponin I release was significantly less with xenon than with total intravenous anesthesia (intention-to-treat: P = 0.05; per-protocol: P = 0.02). Perioperative variables and postoperative outcomes were comparable across all groups, with no safety concerns. CONCLUSIONS: In postoperative cardiac troponin I release, xenon was noninferior to sevoflurane in low-risk, on-pump coronary artery bypass graft surgery patients. Only with xenon was cardiac troponin I release less than with total intravenous anesthesia. Xenon anesthesia appeared safe and feasible.

Published
2017

4. In Reply.

Author

Hofland J, Ouattara A, Schaller M, Bein B, de Liefde I, Fellahi JL, Gruenewald M, Hazebroucq J, Ecoffey C, Joseph P, Heringlake M, Steib A, Coburn M, Amour J, Rozec B, Meybohm P, Preckel B, Hanouz JL, Tritapepe L, Tonner P, Benhaoua H, Roesner JP, Tenbrinck R, Bogers AJ, Mik BG, Coiffic A, Renner J, Steinfath M, Francksen H, Broch O, Haneya A, Guinet P, Daviet L, Brianchon C, Rosier S, Lehot JJ, Paarmann H, Schön J, Hanke T, Ettel J, Olsson S, Klotz S, Samet A, Laurinenas G, Thibaud A, Cristinar M, Collanges O, Levy F, Rossaint R, Stevanovic A, Schaelte G, Stoppe C, Hamou NA, Hariri S, Quessard A, Carillion A, Morin H, Silleran J, Robert D, Crouzet AS, Zacharowski K, Reyher C, Iken S, Weber NC, Hollmann M, Eberl S, Carriero G, Collacchi D, Di Persio A, Fourcade O, Bergt S, and Alms A

Subjects
Anesthesia, Intravenous, Coronary Artery Bypass, Troponin, Sevoflurane, Xenon
Published
2018
Full Text
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5. Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial.

Author

Hofland J, Ouattara A, Fellahi JL, Gruenewald M, Hazebroucq J, Ecoffey C, Joseph P, Heringlake M, Steib A, Coburn M, Amour J, Rozec B, Liefde I, Meybohm P, Preckel B, Hanouz JL, Tritapepe L, Tonner P, Benhaoua H, Roesner JP, Bein B, Hanouz L, Tenbrinck R, Bogers AJJC, Mik BG, Coiffic A, Renner J, Steinfath M, Francksen H, Broch O, Haneya A, Schaller M, Guinet P, Daviet L, Brianchon C, Rosier S, Lehot JJ, Paarmann H, Schön J, Hanke T, Ettel J, Olsson S, Klotz S, Samet A, Laurinenas G, Thibaud A, Cristinar M, Collanges O, Levy F, Rossaint R, Stevanovic A, Schaelte G, Stoppe C, Hamou NA, Hariri S, Quessard A, Carillion A, Morin H, Silleran J, Robert D, Crouzet AS, Zacharowski K, Reyher C, Iken S, Weber NC, Hollmann M, Eberl S, Carriero G, Collacchi D, Di Persio A, Fourcade O, Bergt S, and Alms A

Subjects
Aged, Anesthetics, Inhalation administration & dosage, Biomarkers blood, Coronary Artery Bypass adverse effects, Female, Humans, Male, Middle Aged, Postoperative Complications blood, Postoperative Complications prevention & control, Prospective Studies, Sevoflurane, Single-Blind Method, Treatment Outcome, Anesthesia, Intravenous, Coronary Artery Bypass trends, Internationality, Methyl Ethers administration & dosage, Troponin I blood, Xenon administration & dosage
Abstract

Background: Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models., Methods: In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous anesthesia for anesthesia maintenance. The primary outcome was the cardiac troponin I concentration in the blood 24 h postsurgery. The noninferiority margin for the mean difference in cardiac troponin I release between the xenon and sevoflurane groups was less than 0.15 ng/ml. Secondary outcomes were the safety and feasibility of xenon anesthesia., Results: The first patient included at each center received xenon anesthesia for practical reasons. For all other patients, anesthesia maintenance was randomized (intention-to-treat: n = 492; per-protocol/without major protocol deviation: n = 446). Median 24-h postoperative cardiac troponin I concentrations (ng/ml [interquartile range]) were 1.14 [0.76 to 2.10] with xenon, 1.30 [0.78 to 2.67] with sevoflurane, and 1.48 [0.94 to 2.78] with total intravenous anesthesia [per-protocol]). The mean difference in cardiac troponin I release between xenon and sevoflurane was -0.09 ng/ml (95% CI, -0.30 to 0.11; per-protocol: P = 0.02). Postoperative cardiac troponin I release was significantly less with xenon than with total intravenous anesthesia (intention-to-treat: P = 0.05; per-protocol: P = 0.02). Perioperative variables and postoperative outcomes were comparable across all groups, with no safety concerns., Conclusions: In postoperative cardiac troponin I release, xenon was noninferior to sevoflurane in low-risk, on-pump coronary artery bypass graft surgery patients. Only with xenon was cardiac troponin I release less than with total intravenous anesthesia. Xenon anesthesia appeared safe and feasible.

Published
2017
Full Text
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