Search

© 2014 European Society of Cardiology. Background Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Methods Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Results Mean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Conclusion Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three

In der vorliegenden Arbeit wurden mit Hilfe der Voxel-basierten Morphometrie, basierend auf T1-gewichteten Dünnschichtsequenzen, 20 Patienten mit Essentiellem Tremor (ET) im Vergleich zu einer gesunden Kontrollgruppe untersucht. Die Daten wurden mit Hilfe von SPM99 statistisch ausgewertet. Die Patienten mit ET zeigten dabei disseminierte signifikante morphologische Veränderungen der grauen Substanz im Zerebellum, Kortex und im limbischen System. Eine einzelne Region, die als Generator des ET anzusehen wäre, konnte dabei nicht gefunden werden, insbesondere konnten keine Veränderunegn im Thalamus festgestellt werden., In a voxel-based morphometry study we investigated 20 patients with essential tremor (ET) compared with controls, based on T1-weighted images. Images were analysed in a voxel-by-voxel analysis using statistical parametric mapping (SPM99). Patients with ET showed distibuted significant grey matter morphometric differences in the cerebellum, cortex and the limbic system. We could not identify a single central oscillator responsible for ET, especially no grey matter changes in the thalamus.

In der vorliegenden Arbeit wurden mit Hilfe der Voxel-basierten Morphometrie, basierend auf T1-gewichteten Dünnschichtsequenzen, 20 Patienten mit Essentiellem Tremor (ET) im Vergleich zu einer gesunden Kontrollgruppe untersucht. Die Daten wurden mit Hilfe von SPM99 statistisch ausgewertet. Die Patienten mit ET zeigten dabei disseminierte signifikante morphologische Veränderungen der grauen Substanz im Zerebellum, Kortex und im limbischen System. Eine einzelne Region, die als Generator des ET anzusehen wäre, konnte dabei nicht gefunden werden, insbesondere konnten keine Veränderunegn im Thalamus festgestellt werden., In a voxel-based morphometry study we investigated 20 patients with essential tremor (ET) compared with controls, based on T1-weighted images. Images were analysed in a voxel-by-voxel analysis using statistical parametric mapping (SPM99). Patients with ET showed distibuted significant grey matter morphometric differences in the cerebellum, cortex and the limbic system. We could not identify a single central oscillator responsible for ET, especially no grey matter changes in the thalamus.