Search

Your search keyword '"Etchepare, Fabien"' showing total 40 results
Start Over Author "Etchepare, Fabien"
40 results on '"Etchepare, Fabien"'

12. Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis

Author

Dougados, Maxime, Jousse-Joulin, Sandrine, Mistretta, Frederic, dʼAgostino, Maria-Antonietta, Backhaus, Marina, Bentin, Jacques, Chalès, Gérard, Chary-Valckenaere, Isabelle, Conaghan, Philip, Etchepare, Fabien, Gaudin, Philippe, Grassi, Walter, van der Heijde, Désirée, Sellam, Jérémie, Naredo, Esperanza, Szkudlarek, Marcin, Wakefield, Richard, and Saraux, Alain

Published
2010
Full Text
View/download PDF

14. Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey.

Author

Paillaud, E, Soubeyran, P, Caillet Fauquet, Perrine, Cudennec, T, Brain, Etienne, Terret, C, Etchepare, Fabien, Mourey, L, Aparicio, Thomas, Pamoukdjian, F, Audisio, Riccardo A, Rostoft, S, Hurria, Arti, Bellera, Carine, Mathoulin-Pélissier, Simone, G-CODE collaborators, Paillaud, E, Soubeyran, P, Caillet Fauquet, Perrine, Cudennec, T, Brain, Etienne, Terret, C, Etchepare, Fabien, Mourey, L, Aparicio, Thomas, Pamoukdjian, F, Audisio, Riccardo A, Rostoft, S, Hurria, Arti, Bellera, Carine, Mathoulin-Pélissier, Simone, and G-CODE collaborators

Abstract

To define a core set of geriatric data to be methodically collected in clinical cancer trials of older adults, enabling comparison across trials., info:eu-repo/semantics/published

Published
2018

15. La prévention de la iatrogénicité infectieuse en rhumatologie interventionnelle : des mesures optimales mais adaptées à chaque risque

Author

Maugars, Yves, primary, Albert, Jean-David, additional, Bard, Hervé, additional, Baron, Dominique, additional, Bloch, Jean-Gérard, additional, Bourgeois, Pierre, additional, Cormier, Grégoire, additional, D’Agostino, Maria-Antonietta, additional, Diebolt, Vincent, additional, Dixneuf, Véronique, additional, Etchepare, Fabien, additional, Gandjbakhch, Frédérique, additional, Gaudin, Philippe, additional, Lecoq, Bertrand, additional, Lellouche, Henri, additional, Monod, Pierre, additional, Rolland, Denis, additional, Sanchez, Jean-Philippe, additional, and Le Goff, Benoit, additional

Published
2016
Full Text
View/download PDF

16. Existe-t-il des facteurs qui influencent la concordance entre évaluation clinique et échographie dans la polyarthrite rhumatoïde ?

Author

Mistretta, Frédéric, primary, Mari, Karine, additional, Le Boedec, Marion, additional, Jousse-Joulib, Sandrine, additional, Ferlet, Jean-François, additional, Marhadour, Thierry, additional, Chales, Gérard, additional, Grange, Laurent, additional, Hacquard-Bouder, Cécile, additional, Loeuille, Damien, additional, Sellam, Jérémie, additional, Albert, Jean-David, additional, Bentin, Jacques, additional, Chary-Valckenaere, Isabelle, additional, D’Agostino, Maria-Antonietta, additional, Etchepare, Fabien, additional, Gaudin, Philippe, additional, Hudry, Christophe, additional, Dougados, Maxime, additional, and Saraux, Alain, additional

Published
2016
Full Text
View/download PDF

17. Prevention of iatrogenic infections in interventional rheumatology: Optimal measures but adapted to each risk

Author

Maugars, Yves, primary, Albert, Jean-David, additional, Bard, Hervé, additional, Baron, Dominique, additional, Bloch, Jean-Gérard, additional, Bourgeois, Pierre, additional, Cormier, Grégoire, additional, D’Agostino, Maria-Antonietta, additional, Diebolt, Vincent, additional, Dixneuf, Véronique, additional, Etchepare, Fabien, additional, Gandjbakhch, Frédérique, additional, Gaudin, Philippe, additional, Lecoq, Bertrand, additional, Lellouche, Henri, additional, Monod, Pierre, additional, Rolland, Denis, additional, Sanchez, Jean-Philippe, additional, and Le Goff, Benoit, additional

Published
2016
Full Text
View/download PDF

18. Prediction of radiographic damage in early arthritis by sonographic erosions and power Doppler signal: a longitudinal observational study

Author

Funck-Brentano, Thomas, Gandjbakhch, Frédérique, Etchepare, Fabien, Jousse-Joulin, Sandrine, Miquel, Anne, Cyteval, Catherine, Lukas, Cédric, Tobón, Gabriel J, Saraux, Alain, Boumier, Patrick, Goupille, Philippe, Bourgeois, Pierre, Fautrel, Bruno, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Lapeyronie [Montpellier] (CHU), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP], Service de Rhumatologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Pitié-Salpêtrière [APHP], Université de Brest (UBO) - IFR148, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Hôpital Lapeyronie, Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM), and Service de rhumatologie [Tours]

Subjects
Adult, Male, Metatarsophalangeal Joint, Time Factors, [SDV]Life Sciences [q-bio], MESH: Arthritis, Severity of Illness Index, MESH: Prognosis, Cohort Studies, Metacarpophalangeal Joint, Predictive Value of Tests, MESH: Severity of Illness Index, Outcome Assessment, Health Care, MESH: Arthrography, Humans, MESH: Metacarpophalangeal Joint, Longitudinal Studies, MESH: Longitudinal Studies, Arthrography, MESH: Outcome Assessment (Health Care), MESH: Cohort Studies, MESH: Middle Aged, MESH: Humans, Arthritis, MESH: Time Factors, MESH: Adult, Ultrasonography, Doppler, Middle Aged, Prognosis, MESH: Metatarsophalangeal Joint, MESH: Predictive Value of Tests, MESH: Male, [SDV] Life Sciences [q-bio], MESH: Joints, MESH: Ultrasonography, Doppler, Disease Progression, MESH: Disease Progression, Female, Joints, MESH: Female
Abstract

International audience; OBJECTIVE: To assess the ability of ultrasonography (US) to predict radiographic damage in early arthritis. METHODS: ESPOIR is a multicentric cohort of early arthritis (i.e., ≥2 swollen joints between 6 weeks and 6 months). US synovitis in B mode, power Doppler (PD) mode, and erosions were searched on the second through the fifth metacarpophalangeal and fifth metatarsophalangeal joints according to Outcome Measures in Rheumatology definitions. Structural radiographic progression was assessed using the modified Sharp/van der Heijde erosion score (SHS) at baseline and 1 and 2 years. Predictive factors of erosive arthritis at 2 years and rapid radiographic progression (RRP) at 1 year (defined by change of SHS ≥5) were searched. RESULTS: A total of 127 patients were included, with a mean ± SD Disease Activity Score in 28 joints of 5.1 ± 1.3; 37.6% were anti-citrullinated protein antibody positive and 27.6% had typical rheumatoid arthritis (RA) erosions on radiographs. At 2 years, 42 patients (39.2%) had typical RA erosions. US erosions predicted radiographic evidence of erosive arthritis (odds ratio [OR] 1.44, 95% confidence interval [95% CI] 1.04-1.98). PD synovitis score was predictive of RRP at 1 year (OR 1.22, 95% CI 1.04-1.42). US erosions and PD synovitis scores were associated with change of SHS on linear regression. Of the 1,184 analyzed joints, 105 (8.9%) had radiographic erosion at 1 year. At the joint level, baseline US erosions were predictive of the presence of radiographic erosions at 1 year (P < 0.001). The same trend was observed in the joints without radiographic erosions at baseline (P = 0.052). CONCLUSION: US is useful to evaluate the potential severity of early arthritis: US erosions and PD-positive synovitis have prognostic value to predict future radiographic damage.

Published
2012
Full Text
View/download PDF

19. Comparaison de la capacité des synovites à prédire une aggravation radiologique en fonction de l'examen articulaire (clinique versus échographique) au cours de la polyarthrite rhumatoïde

Author

Dougados, Maxime, Devauchelle-Pensec, Valérie, Ferlet, Jean-François, Bentin, Jacq, Jousse-Joulin, Sandrine, D'Agostino, Maria-Antonietta, Chalès, Gérard, Chary-Valckenaere, Isabelle, Etchepare, Fabien, Gaudin, Philippe, Mariette, Xavier, Saraux, Alain, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Statistique, RCTS, Lyon, RCTS Lyon, Service de Rhumatologie, CHU Brugmann, CHU Brugmann, Belgium, Service de Rhumatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de rhumatologie [Rennes] = Rheumatology [Rennes], CHU Pontchaillou [Rennes], Service de Rhumatologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Physiopathologie, Pharmacologie et Ingénierie articulaires (PPIA), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Service de rhumatologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Ambroise Paré, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Sud, Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Physiopathologie, Pharmacologie et Ingénierie articulaires ( PPIA ), Université Henri Poincaré - Nancy 1 ( UHP ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Rhumatologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-Hôpital Michallon, Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre, Service de Rhumatologie [CHU Pitié Salpêtrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[ SDV.IMM ] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

20. Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: Influence on disease activity score-28 values (SEA-repro study part I)

Author

Marhadour, Thierry, Jousse-Joulin, Sandrine, Saraux, Alain, Chalès, Gérard, Albert, Jean David, Grange, Laurent, Gaudin, Philippe, Hacquard, Cécile, D'Agostino, Maria Antonietta, Loeuille, Damien, Valckenaere, Isabelle Chary, Sellam, Jérémie, Bentin, Jacques, Etchepare, Fabien, Hudry, Christophe, Dougados, Maxime, Marhadour, Thierry, Jousse-Joulin, Sandrine, Saraux, Alain, Chalès, Gérard, Albert, Jean David, Grange, Laurent, Gaudin, Philippe, Hacquard, Cécile, D'Agostino, Maria Antonietta, Loeuille, Damien, Valckenaere, Isabelle Chary, Sellam, Jérémie, Bentin, Jacques, Etchepare, Fabien, Hudry, Christophe, and Dougados, Maxime

Abstract

Objectives. To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28). Methods. Seven healthcare professionals from different cities examined the same patients with active non-early rheumatoid arthritis (RA; duration > 4 yrs), for whom a treatment change was being considered. There was no training session and the examination was to be performed as quickly as possible. The healthcare professionals assessed the 28 joints of the DAS28 in 7 patients (196 joints), then reexamined the same 28 joints in 4 of these 7 patients (112 joints), who had been rendered unrecognizable. Then 7 sonographers examined each of the 7 patients twice, using B-mode and power Doppler ultrasound (PD). The reference standards were presence of synovitis according to at least 50% of clinical examiners and 50% of sonographers. Agreement was assessed by Cohen's kappa statistic. Results. Intraobserver reliability ranged from 0.31 (least experienced research technician) to 0.77 (most experienced physician). Interobserver reliability ranged from 0.18 to 0.62. The largest difference between the lowest and the highest swollen joint counts in the same patient was 15, and the greatest variation in the DAS28 score was 0.92. Agreement between clinical and sonographic reference standards was 0.46, 0.37, and 0.36 for B-mode, PD, and both, respectively. Conclusion. Clinical inter- and intraobserver reliability is highly dependent on the examiner. Consequences on the DAS28 score can be substantial. Agreement with sonography is poor when both B-mode and PD are used but seems better, although low, when B-mode is used alone. The Journal of Rheumatology Copyright © 2010. All rights reserved., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

21. Reproducibility of joint swelling assessment by sonography in patients with long-lasting rheumatoid arthritis (SEA-repro study part II)

Author

Jousse-Joulin, Sandrine, Marhadour, Thierry, Saraux, Alain, D'Agostino, Maria Antonietta, Hacquard, Cécile, Albert, Jean David, Chalès, Gérard, Bentin, Jacques, Valckenaere, Isabelle Chary, Loeuille, Damien, Etchepare, Fabien, Gaudin, Philippe, Grange, Laurent, Hudry, Christophe, Dougados, Maxime, Sellam, Jérémie, Jousse-Joulin, Sandrine, Marhadour, Thierry, Saraux, Alain, D'Agostino, Maria Antonietta, Hacquard, Cécile, Albert, Jean David, Chalès, Gérard, Bentin, Jacques, Valckenaere, Isabelle Chary, Loeuille, Damien, Etchepare, Fabien, Gaudin, Philippe, Grange, Laurent, Hudry, Christophe, Dougados, Maxime, and Sellam, Jérémie

Abstract

Objective. To evaluate the intraobserver and interobserver reproducibility of B-mode and power Doppler (PD) sonography in patients with active long-standing rheumatoid arthritis (RA) comparatively with clinical data. Methods. In each of 7 patients being considered for a change in their RA treatment regimen, 7 healthcare professionals examined the 28 joints used in the Disease Activity Score 28-joint count (DAS28). Then 7 sonographers examined each of the 7 patients twice, using previously published B-mode and PD grading systems. The clinical reference standard was presence of synovitis according to at least 4/7 examiners. The sonographic reference standard was at least grade 1 (ALG1) or 2 (ALG2) synovitis according to at least 4/7 sonographers. Interobserver reproducibility of sonography was assessed versus the sonographer having the best intraobserver reproducibility. Agreement was measured by Cohen's kappa statistic. Results. Intraobserver and interobserver reproducibility of B-mode and PD used separately was fair to good.Agreement between clinicians and sonographers at all sites using B-mode, PD, and both was 0.46, 0.37, and 0.36, respectively, for grade 1 synovitis; and 0.58, 0.19, and 0.19 for grade 2 synovitis. The number of joints with synovitis was smaller by physical examination (36.7%) than by B-mode with ALG1 (58.6%; p < 0.001). The number of joints with synovitis was higher by physical examination than by PD with both ALG1 (17.8%; p < 0.0001) and ALG2 (6.6%; p < 0.0001). Conclusion. PD findings explain most of the difference between clinical and sonographic joint assessments for synovitis in patients with long-standing RA. The Journal of Rheumatology Copyright © 2010. All rights reserved., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

22. Prediction of Radiographic Damage in Early Arthritis by Sonographic Erosions and Power Doppler Signal: A Longitudinal Observational Study

Author

Funck‐Brentano, Thomas, primary, Gandjbakhch, Frédérique, additional, Etchepare, Fabien, additional, Jousse‐Joulin, Sandrine, additional, Miquel, Anne, additional, Cyteval, Catherine, additional, Lukas, Cédric, additional, Tobón, Gabriel J., additional, Saraux, Alain, additional, Boumier, Patrick, additional, Goupille, Philippe, additional, Bourgeois, Pierre, additional, and Fautrel, Bruno, additional

Published
2013
Full Text
View/download PDF

23. Factors Influencing Concordance Between Clinical and Ultrasound Findings in Rheumatoid Arthritis

Author

Le BOEDEC, MARION, primary, JOUSSE-JOULIN, SANDRINE, additional, FERLET, JEAN-FRANÇOIS, additional, MARHADOUR, THIERRY, additional, CHALES, GÉRARD, additional, GRANGE, LAURENT, additional, HACQUARD-BOUDER, CÉCILE, additional, LOEUILLE, DAMIEN, additional, SELLAM, JÉRÉMIE, additional, ALBERT, JEAN-DAVID, additional, BENTIN, JACQUES, additional, CHARY-VALCKENAERE, ISABELLE, additional, D’AGOSTINO, MARIA-ANTONIETTA, additional, ETCHEPARE, FABIEN, additional, GAUDIN, PHILIPPE, additional, HUDRY, CHRISTOPHE, additional, DOUGADOS, MAXIME, additional, and SARAUX, ALAIN, additional

Published
2013
Full Text
View/download PDF

24. Power Doppler ultrasound, but not low‐field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity

Author

Foltz, Violaine, primary, Gandjbakhch, Frédérique, additional, Etchepare, Fabien, additional, Rosenberg, Carole, additional, Tanguy, Marie Laure, additional, Rozenberg, Sylvie, additional, Bourgeois, Pierre, additional, and Fautrel, Bruno, additional

Published
2011
Full Text
View/download PDF

26. Dr. Banal, et al reply

Author

BANAL, FREDERIC, primary, GANDJBAKHCH, FREDERIQUE, additional, FOLTZ, VIOLAINE, additional, GOLDCHER, ALAIN, additional, ETCHEPARE, FABIEN, additional, ROZENBERG, SYLVIE, additional, KOEGER, ANNE-CLAUDE, additional, BOURGEOIS, PIERRE, additional, and FAUTREL, BRUNO, additional

Published
2010
Full Text
View/download PDF

27. Reproducibility of Joint Swelling Assessments in Long-lasting Rheumatoid Arthritis: Influence on Disease Activity Score-28 Values (SEA-Repro Study Part I)

Author

MARHADOUR, THIERRY, primary, JOUSSE-JOULIN, SANDRINE, additional, CHALÈS, GÉRARD, additional, GRANGE, LAURENT, additional, HACQUARD, CÉCILE, additional, LOEUILLE, DAMIEN, additional, SELLAM, JÉRÉMIE, additional, ALBERT, JEAN-DAVID, additional, BENTIN, JACQUES, additional, CHARY VALCKENAERE, ISABELLE, additional, d’AGOSTINO, MARIA-ANTONIETTA, additional, ETCHEPARE, FABIEN, additional, GAUDIN, PHILIPPE, additional, HUDRY, CHRISTOPHE, additional, DOUGADOS, MAXIME, additional, and SARAUX, ALAIN, additional

Published
2010
Full Text
View/download PDF

28. Reproducibility of Joint Swelling Assessment by Sonography in Patients with Long-lasting Rheumatoid Arthritis (SEA-Repro Study Part II)

Author

JOUSSE-JOULIN, SANDRINE, primary, d’AGOSTINO, MARIA ANTONIETTA, additional, MARHADOUR, THIERRY, additional, ALBERT, JEAN DAVID, additional, BENTIN, JACQUES, additional, CHARY VALCKENAERE, ISABELLE, additional, ETCHEPARE, FABIEN, additional, GAUDIN, PHILIPPE, additional, HUDRY, CHRISTOPHE, additional, CHALÈS, GÉRARD, additional, GRANGE, LAURENT, additional, HACQUARD, CÉCILE, additional, LOEUILLE, DAMIEN, additional, SELLAM, JÉRÉMIE, additional, DOUGADOS, MAXIME, additional, and SARAUX, ALAIN, additional

Published
2010
Full Text
View/download PDF

34. L’échographie et l’imagerie par résonance magnétique ne permettent pas une évaluation précoce de la réponse à une biothérapie chez les patients atteints de polyarthrite rhumatoïde

Author

Foltz, Violaine, primary, Loeuille, Damien, additional, Etchepare, Fabien, additional, Chary-Valckenaere, Isabelle, additional, Rosenberg, Carole, additional, Tanguy, Marie-Laure, additional, Fautrel, Bruno, additional, and Bourgeois, Pierre, additional

Published
2009
Full Text
View/download PDF

40. The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound.

Author

Dougados M, Devauchelle-Pensec V, Ferlet JF, Jousse-Joulin S, D'Agostino MA, Backhaus M, Bentin J, Chalès G, Chary-Valckenaere I, Conaghan P, Wakefield RJ, Etchepare F, Gaudin P, Grassi W, Heijde Dv, Mariette X, Naredo E, and Szkudlarek M

Subjects
Adult, Aged, Arthritis, Rheumatoid epidemiology, Disease Progression, Female, Follow-Up Studies, Humans, Joints diagnostic imaging, Joints pathology, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Risk Factors, Synovitis epidemiology, Arthritis, Rheumatoid diagnostic imaging, Arthritis, Rheumatoid pathology, Physical Examination standards, Synovitis diagnostic imaging, Synovitis pathology, Ultrasonography, Doppler standards
Abstract

Objectives: To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA)., Methods: Patients with RA., Study Design: Prospective, 2-year follow-up., Data Collected: Synovitis (32 joints (2 wrists, 10 metacarpophalangeal, 10 proximal interphalangeal, 10 metatarsophalangeal)) at baseline and after 4 months of therapy by clinical, US grey scale (GS-US) and power doppler (PD-US); x-rays at baseline and at year 2., Analysis: Measures of association (OR) were tested between structural deterioration and the presence of baseline synovitis, or its persistence, after 4 months of therapy using generalised estimating equation analysis., Results: Structural deterioration was observed in 9% of the 1888 evaluated joints in 59 patients. Baseline synovitis increased the risk of structural progression: OR=2.01 (1.36-2.98) p<0.001 versus 1.61 (1.06-2.45) p=0.026 versus 1.75 (1.18-2.58) p=0.005 for the clinical versus US-GS versus US-PD evaluation, respectively. In the joints with normal baseline examination (clinical or US), an increased probability for structural progression in the presence of synovitis for the other modality was also observed (OR=2.16 (1.16-4.02) p=0.015 and 3.50 (1.77-6.95) p<0.001 for US-GS and US-PD and 2.79 (1.35-5.76) p=0.002) for clinical examination. Persistent (vs disappearance) synovitis after 4 months of therapy was also predictive of subsequent structural progression., Conclusions: This study confirms the validity of synovitis for predicting subsequent structural deterioration irrespective of the modality of examination of joints, but also suggests that both clinical and ultrasonographic examinations may be relevant to optimally evaluate the risk of subsequent structural deterioration.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results