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2. Diet quality and associations with lactate and metabolic syndrome in bipolar disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J., Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A., Fredembach, B., Suisse, A., Denoual, Q., Polosan, M., Galliot, A.M., Brehon, L., Bonny, G., Durand, L., Feuga, V., Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Samalin, L., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Godin, Ophelia, Choi, Jaehyoung, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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3. Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, PM, Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J, Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A, Fredembach, B., Suisse, A., Denoual, Q, Polosan, M, Galliot, A.M., Brehon, L., Bonny, G, Durand, L, Feuga, V, Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A, Loftus, J., Medecin, I., Samalin, L., Llorca, PM., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Choi, Jaehyoung, Godin, Ophelia, Chernega, Timofei, Kwak, Haejin Angela, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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5. Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: Results from the FACE-BD cohort

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Drancourt, N., Sanchez, J.P., Saliou, E., Hebbache, C., Petrucci, J., Willaume, L., Bourdin, E., Bellivier, F., Carminati, M., Marlinge, E., Meheust, J., Hennion, V., Francisque, H., Aouizerate, B., Da Ros, N., Desage, A., Elkael, C., Gard, S., Hoorelbeke, F., M'bailara, K., Minois, I., Sportich, J., Boukhobza, L., Benramdane, M., Courtet, P., Deffinis, B., Denat, S., Ducasse, D., Gachet, M., Molière, F., Nass, L., Tarquini, G., Belzeaux, R., Cermolacce, M., Groppi, F., Moreau, E., Lefrere, A., Lescalier, L., Pastol, J., Viglianese, N., Cohen, R., Gross, G., Schwan, R., Schwitzer, T., Wajsbrot-Elgrabli, O., Bougerol, T., Fredembach, B., Denoual, Q, Bertrand, A., Pouchon, A., Polosan, M., Bonny, G., Brehon, L., Durand, L., Feuga, V., Galliot, A.M., Kayser, N., Passerieux, C., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Llorca, PM., Samalin, L., Foures, L., Lacelle, D., Pires, S., Doriat, C., Blanc, O., Bennabi, D., Nicolier, M., Vidal, N., Brunet-Gouet, E., Frileux, S., D'Amato, T., Januel, D., and Walter, M.

Published
2023
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8. Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)

Author

Vancappel, A, Dansou, Y, Godin, O, Haffen, E, Yrondi, A, Stéphan, F, Richieri, R, Molière, F, Horn, M, Allauze, E, Genty, JB, Bouvard, A, Dorey, JM, Meyrel, M, Camus, V, Fond, G, Péran, B, Walter, M, Anguill, L, Scotto d'Apollonia, C, Nguon, AS, Fredembach, B, Holtzmann, J, Vilà, E, Petrucci, J, Rey, Etain, B, Carminati, M, Courtet, P, Vaiva, G, Llorca, PM, Leboyer, M, Aouizerate, B, Bennabi, D, and El-Hage, W

Published
2021
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9. Future directions in the field of Bipolar Disorder

Author

Reininghaus, E.Z., primary, Dalkner, N., additional, L, Wels, additional, Stijic, M., additional, Bechdolf, A., additional, Bellivier, F., additional, Bergink, V., additional, Ceylan, D., additional, Correll, C.U., additional, Etain, B., additional, Fagiolini, A., additional, Geddes, J., additional, Gonzalez-Pinto, A., additional, Goodwin, G., additional, Hajek, T., additional, Henry, C., additional, Kessing, L.V., additional, Kupka, R., additional, Lagerberg, T.V., additional, Landen, M., additional, Licht, R.W., additional, Martinez-Cengotitabengoa, M., additional, Morken, G., additional, Nielsen, R.E., additional, Rietschel, M., additional, Ritter, P., additional, Schulze, T., additional, Scott, J., additional, Severus, E., additional, Squassina, A., additional, Suwalska, A., additional, Vieta, E., additional, Yildiz, A., additional, Reif, A., additional, Manchia, M., additional, and Andreassen, O.A., additional

Published
2024
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10. Clinical characteristics of bipolar disorders with postpartum depressive onset

Author

Etain, B., Henry, C., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Drancourt, N., Sanchez, J.P., Saliou, E., Hebbache, C., Petrucci, J., Willaume, L., Bourdin, E., Bellivier, F., Carminati, M., Marlinge, E., Meheust, J., Antoniol, B., Desage, A., Gard, S., Jutant, A., Mbailara, K., Minois, I., Zanouy, L., Abettan, C., Bardin, L., Cazals, A., Courtet, P., Deffinis, B., Ducasse, D., Gachet, M., Henrion, A., Martinerie, E., Molière, F., Noisette, B., Tarquini, G., Azorin, J.M., Belzeaux, R., Correard, N., Consoloni, J.L., Groppi, F., Lescalier, L., Montant, J., Rebattu, M., Viglianese, N., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Fredembach, B., Suisse, A., Halili, B., Pouchon, A., Polosan, M., Galliot, A.M., Grévin, I., Cannavo, A.S., Kayser, N., Passerieux, C., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Tebeka, Sarah, Godin, Ophelia, Mazer, Nicolas, Bellivier, Frank, Courtet, Philippe, Etain, Bruno, Gard, Sébastien, Leboyer, Marion, Llorca, Pierre-Michel, Loftus, Joséphine, Olié, Emilie, Passerieux, Christine, Polosan, Mircea, Schwan, Raymund, Belzeaux, Raoul, and Dubertret, Caroline

Published
2021
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11. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Author

Witt, SH, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, CS, Treutlein, J, Degenhardt, F, Forstner, AJ, Heilmann-Heimbach, S, Dietl, L, Schwarze, CE, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, TM, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, OA, Babadjanova, G, Bass, NJ, Bauer, M, Baune, BT, Bellivier, F, Bergen, S, Bethell, A, Biernacka, JM, Blackwood, DHR, Boks, MP, Boomsma, DI, Børglum, AD, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschøn, HN, Byrne, EM, Cervantes, P, Clarke, T-K, Craddock, N, Cruceanu, C, Curtis, D, Czerski, PM, Dannlowski, U, Davis, T, de Geus, EJC, Di Florio, A, Djurovic, S, Domenici, E, Edenberg, HJ, Etain, B, Fischer, SB, Forty, L, Fraser, C, Frye, MA, Fullerton, JM, Gade, K, Gershon, ES, Giegling, I, Gordon, SD, Gordon-Smith, K, Grabe, HJ, Green, EK, Greenwood, TA, Grigoroiu-Serbanescu, M, Guzman-Parra, J, Hall, LS, Hamshere, M, Hauser, J, Hautzinger, M, Heilbronner, U, Herms, S, Hitturlingappa, S, Hoffmann, P, Holmans, P, Hottenga, J-J, Jamain, S, Jones, I, Jones, LA, Juréus, A, Kahn, RS, Kammerer-Ciernioch, J, Kirov, G, Kittel-Schneider, S, Kloiber, S, Knott, SV, Kogevinas, M, Landén, M, Leber, M, Leboyer, M, Li, QS, Lissowska, J, Lucae, S, Martin, NG, Mayoral-Cleries, F, McElroy, SL, McIntosh, AM, McKay, JD, and McQuillin, A

Subjects
Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Humans, Genetic Predisposition to Disease, Case-Control Studies, Bipolar Disorder, Depressive Disorder, Major, Borderline Personality Disorder, Schizophrenia, Genotype, Multifactorial Inheritance, Adolescent, Adult, Aged, Middle Aged, Female, Male, Genome-Wide Association Study, Young Adult, Depressive Disorder, Major, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

Published
2017

12. Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study

Author

Etain, B., Olié, E., Leboyer, M., Llorca, P.M., Henry, C., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Sanchez, J.P., Saliou, E., Hebbache, C., Petrucci, J., Willaume, L., Bourdin, E., Bellivier, F., Carminati, M., Maruani, J., Marlinge, E., Meheust, J., Antoniol, B., Desage, A., Gard, S., Jutant, A., Mbailara, K., Minois, I., Zanouy, L., Abettan, C., Bardin, L., Cazals, A., Courtet, P., Deffinis, B., Ducasse, D., Gachet, M., Henrion, A., Martinerie, E., Molière, F., Noisette, B., Tarquini, G., Azorin, J.M., Belzeaux, R., Correard, N., Consoloni, J.L., Groppi, F., Lescalier, L., Montant, J., Rebattu, M., Viglianese, N., Cohen, R., Gross, G., Schwan, R., Schwitzer, T., Wajsbrot-Elgrabli, O., Bougerol, T., Fredembach, B., Suisse, A., Halili, B., Gaoua, Z., Polosan, M., Cannavo, A.S., Galliot, A.M., Grévin, I., Kayser, N., Liaskovski, G., Passerieux, C., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., and Aouizerate, B.

Published
2021
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13. Evolution and characteristics of the use of valproate in women of childbearing age with bipolar disorder: Results from the FACE-BD cohort

Author

Samalin, L., Godin, O., Olié, E., Etain, B., Henry, C., Pelletier, A., Poinso, F., Encely, L., Mazer, N., Roux, P., Loftus, J, Gard, S., Bennabi, D., Polosan, M., Schwitzer, T., Aubin, V., Schwan, R., Passerieux, C., Bougerol, T., Dubertret, C., Aouizerate, B., Haffen, E., Courtet, P., Bellivier, F., Leboyer, M., Llorca, P.M., and Belzeaux, R.

Published
2020
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15. Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: Results from the FACE-BD cohort

Author

Vidal, N., primary, Brunet-Gouet, E., additional, Frileux, S., additional, Aouizerate, B., additional, Aubin, V., additional, Belzeaux, R., additional, Courtet, P., additional, D'Amato, T., additional, Dubertret, C., additional, Etain, B., additional, Haffen, E., additional, Januel, D., additional, Leboyer, M., additional, Lefrere, A., additional, Llorca, P.M., additional, Marlinge, E., additional, Olié, E., additional, Polosan, M., additional, Schwan, R., additional, Walter, M., additional, Passerieux, C., additional, Roux, P., additional, Barteau, V., additional, Bensalem, S., additional, Godin, O., additional, Laouamri, H., additional, Souryis, K., additional, Hotier, S., additional, Pelletier, A., additional, Drancourt, N., additional, Sanchez, J.P., additional, Saliou, E., additional, Hebbache, C., additional, Petrucci, J., additional, Willaume, L., additional, Bourdin, E., additional, Bellivier, F., additional, Carminati, M., additional, Meheust, J., additional, Hennion, V., additional, Francisque, H., additional, Da Ros, N., additional, Desage, A., additional, Elkael, C., additional, Gard, S., additional, Hoorelbeke, F., additional, M'bailara, K., additional, Minois, I., additional, Sportich, J., additional, Boukhobza, L., additional, Benramdane, M., additional, Deffinis, B., additional, Denat, S., additional, Ducasse, D., additional, Gachet, M., additional, Molière, F., additional, Nass, L., additional, Tarquini, G., additional, Cermolacce, M., additional, Groppi, F., additional, Moreau, E., additional, Lescalier, L., additional, Pastol, J., additional, Viglianese, N., additional, Cohen, R., additional, Gross, G., additional, Schwitzer, T., additional, Wajsbrot-Elgrabli, O., additional, Bougerol, T., additional, Fredembach, B., additional, Denoual, Q, additional, Bertrand, A., additional, Pouchon, A., additional, Bonny, G., additional, Brehon, L., additional, Durand, L., additional, Feuga, V., additional, Galliot, A.M., additional, Kayser, N., additional, Cussac, I., additional, Dupont, M.A., additional, Loftus, J., additional, Medecin, I., additional, Mazer, N., additional, Portalier, C., additional, Scognamiglio, C., additional, Bing, A., additional, Laurent, P., additional, Llorca, PM., additional, Samalin, L., additional, Foures, L., additional, Lacelle, D., additional, Pires, S., additional, Doriat, C., additional, Blanc, O., additional, Bennabi, D., additional, and Nicolier, M., additional

Published
2023
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16. Measuring the Patient Experience of Mental Health Care: A Systematic and Critical Review of Patient-Reported Experience Measures

Author

Fernandes S, Fond G, Zendjidjian XY, Baumstarck K, Lançon C, Berna F, Schurhoff F, Aouizerate B, Henry C, Etain B, Samalin L, Leboyer M, Llorca PM, Coldefy M, Auquier P, and Boyer L

Subjects
patient-reported experience measures, patient experience, patient satisfaction, health services research, schizophrenia, bipolar disorder, major depression, systematic review., Medicine (General), R5-920
Abstract

Sara Fernandes,1 Guillaume Fond,1 Xavier Yves Zendjidjian,1 Karine Baumstarck,1 Christophe Lançon,1 Fabrice Berna,2 Franck Schurhoff,2 Bruno Aouizerate,2 Chantal Henry,2 Bruno Etain,2 Ludovic Samalin,2 Marion Leboyer,2 Pierre-Michel Llorca,2 Magali Coldefy,3 Pascal Auquier,1 Laurent Boyer1 On behalf of the French PREMIUM Group1Aix-Marseille University, School of Medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, Marseille, France; 2FondaMental Foundation, Créteil, France; 3Institute for Research and Information in Health Economics (IRDES), Paris, FranceCorrespondence: Sara FernandesAix-Marseille University, School of Medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, Marseille, FranceTel +33-660185077Email sfernandes.sara@gmail.comBackground: There is growing concern about measuring patient experience with mental health care. There are currently numerous patient-reported experience measures (PREMs) available for mental health care, but there is little guidance for selecting the most suitable instruments. The objective of this systematic review was to provide an overview of the psychometric properties and the content of available PREMs.Methods: A comprehensive review following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines was conducted using the MEDLINE database with no date restrictions. The content of PREMs was analyzed using an inductive qualitative approach, and the methodological quality was assessed according to Pesudovs quality criteria.Results: A total of 86 articles examining 75 PREMs and totaling 1932 items were included. Only four PREMs used statistical methods from item response theory (IRT). The 1932 items covered seven key mental health care domains: interpersonal relationships (22.6%), followed by respect and dignity (19.3%), access and care coordination (14.9%), drug therapy (14.1%), information (9.6%), psychological care (6.8%) and care environment (6.1%). Additionally, a few items focused on patient satisfaction (6.7%) rather than patient experience. No instrument covered the latent trait continuum of patient experience, as defined by the inductive qualitative approach, and the psychometric properties of the instruments were heterogeneous.Conclusion: This work is a critical step in the creation of an item library to measure mental health care patient-reported experience that will be used in France to develop, validate, and standardize item banks and computerized adaptive testing (CAT) based on IRT. It will also provide internationally replicable measures that will allow direct comparisons of mental health care systems.Trial Registration: NCT02491866.Keywords: patient-reported experience measures, patient experience, patient satisfaction, health services research, schizophrenia, bipolar disorder, major depression, systematic review

Published
2020

19. Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE‐BD cohort.

Author

Godin, O., Olié, E., Fond, G., Aouizerate, B., Aubin, V., Bellivier, F., Belzeaux, R., Courtet, P., Dubertret, C., Haffen, E., Lefrere, A., Llorca, P. M., Polosan, M., Roux, P., Samalin, L., Schwan, R., Etain, B., Leboyer, M., Llorca, PM, and Barteau, V.

Subjects
BIPOLAR disorder, METABOLIC syndrome, ALCOHOLISM, SLEEP interruptions, LONGITUDINAL method
Abstract

Introduction: Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS. Methods: Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE‐BD) cohort and followed‐up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow‐up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow‐up. We applied inverse probability‐of‐censoring weighting method to minimize selection bias due to loss during follow‐up. Results: Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow‐up. Multivariable analyses showed that incident MetS during follow‐up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, p = 0.0004), presence of a mood recurrence during follow‐up (OR = 1.91, 95% CI = 1.22–3.00, p = 0.0049), prolonged exposure to second‐generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components. Conclusion: We observed a high incidence of MetS during a 3 years follow‐up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1.

Author

Spano, Luana, Marie-Claire, Cynthia, Godin, Ophélia, Lebras, Apolline, Courtin, Cindie, Laplanche, Jean-Louis, Leboyer, Marion, Aouizerate, Bruno, Lefrere, Antoine, Belzeaux, Raoul, Courtet, Philippe, Olié, Emilie, Dubertret, Caroline, Schwan, Raymund, Aubin, Valérie, Roux, Paul, Polosan, Mircea, Samalin, Ludovic, Haffen, Emmanuel, and Etain, B.

Published
2024
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21. The Patient-Reported Experience Measure for Improving qUality of care in Mental health (PREMIUM) project in France: study protocol for the development and implementation strategy

Author

Fernandes S, Fond G, Zendjidjian X, Michel P, Baumstarck K, Lancon C, Berna F, Schurhoff F, Aouizerate B, Henry C, Etain B, Samalin L, Leboyer M, Llorca PM, Coldefy M, Auquier P, and Boyer L

Subjects
patient reported experience measures, quality of care, item bank, computerized adaptive testing, psychiatry, Medicine (General), R5-920
Abstract

Sara Fernandes,1 Guillaume Fond,1 Xavier Zendjidjian,1 Pierre Michel,1 Karine Baumstarck,1 Christophe Lancon,1 Fabrice Berna,2 Franck Schurhoff,2 Bruno Aouizerate,2 Chantal Henry,2 Bruno Etain,2 Ludovic Samalin,2 Marion Leboyer,2 Pierre-Michel Llorca,2 Magali Coldefy,3 Pascal Auquier,1 Laurent Boyer1 On behalf of the French PREMIUM Group 1Aix-Marseille University, School of Medicine, CEReSS – Health Service Research and Quality of Life Center – EA 3279 Research Unit, Marseille, France; 2FondaMental Foundation, Créteil, France; 3Institute for Research and Information in Health Economics (IRDES), Paris, France Background: Measuring the quality and performance of health care is a major challenge in improving the efficiency of a health system. Patient experience is one important measure of the quality of health care, and the use of patient-reported experience measures (PREMs) is recommended. The aims of this project are 1) to develop item banks of PREMs that assess the quality of health care for adult patients with psychiatric disorders (schizophrenia, bipolar disorder, and depression) and to validate computerized adaptive testing (CAT) to support the routine use of PREMs; and 2) to analyze the implementation and acceptability of the CAT among patients, professionals, and health authorities.Methods: This multicenter and cross-sectional study is based on a mixed method approach, integrating qualitative and quantitative methodologies in two main phases: 1) item bank and CAT development based on a standardized procedure, including conceptual work and definition of the domain mapping, item selection, calibration of the item bank and CAT simulations to elaborate the administration algorithm, and CAT validation; and 2) a qualitative study exploring the implementation and acceptability of the CAT among patients, professionals, and health authorities.Discussion: The development of a set of PREMs on quality of care in mental health that overcomes the limitations of previous works (ie, allowing national comparisons regardless of the characteristics of patients and care and based on modern testing using item banks and CAT) could help health care professionals and health system policymakers to identify strategies to improve the quality and efficiency of mental health care.Trial registration: NCT02491866. Keywords: patient-reported experience measures, quality of care, item bank, computerized adaptive testing, psychiatry

Published
2019

23. Childhood trauma, dimensions of psychopathology and the clinical expression of bipolar disorders: A pathway analysis

Author

Henry, C., Etain, B., Leboyer, M., Laouamri, H., Souryis, K., Godin, O., Raust, A., Sportiche, S., Geoffroy, P.A., Aouizerate, B., Desage, A., Olie, E., Ducasse, D., Moliere, F., Belzeaux, R., Viglianaise, N., Lescalier, L., Job, S., Cohen, R., Wajsbrot-Elgrabli, O., Polosan, M., Garcon, S., Hardy-Bayle, M.C., Roux, P., Kayser, N., Grevin, I., Loftus, J., Albertini, L., Lajnef, M., Aubin, V., Azorin, J.M., Bellivier, F., Bougerol, T., Courtet, P., Gard, S., Kahn, J.P., and Passerieux, C.

Published
2017
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26. Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise - Bipolar Disorder cohort

Author

Flaudias, Valentin, Samalin, Ludovic, Godin, Ophélia, Gard, Sébastien, Brousse, Georges, Loftus, Joséphine, Aubin, Valérie, Belzeaux, Raoul, Dubertret, Caroline, Le Strat, Yann, Mazer, Nicolas, de Prémorel, Alix, Roux, Paul, Polosan, Mircea, Schwitzer, Thomas, Aouizerate, Bruno, Llorca, Pierre Michel, Biseul, Isabelle, Etain, B., Moirand, Rémi, Olié, Émilie, Haffen, Emmanuel, Leboyer, Marion, Courtet, Philippe, Icick, Romain, Guillaume, Sébastien, Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Fondation FondaMental [Créteil], Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Princesse Grace, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Psychothérapique de Nancy [Laxou] (CPN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Centre Hospitalier le Vinatier [Bron], Hôpital Lapeyronie [Montpellier] (CHU), Service de chirurgie pédiatrique [CHU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Fondation FondaMental, FFM, Agence Nationale de la Recherche, ANR: ANR-10- COHO-10-01, ANR-11-IDEX-0004-02, Institut National de la Santé et de la Recherche Médicale, Inserm, This research was supported by the FondaMental Foundation , French National Institute of Health and Medical Research (INSERM), Public Hospitals of Paris (AP-HP), and by the French National Research Agency (ANR)'s Investment for the Future program (ref. nos ANR-11-IDEX-0004-02 and ANR-10- COHO-10-01 ). The funding sources had no role in the study design, data collection, analysis, preparation of the manuscript, or decision to submit the manuscript for publication., ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), and ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010)

Subjects
Psychiatry and Mental health, Clinical Psychology, Bipolar disorder, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Types, Eating disorders, Comorbidity
Abstract

International audience; Background: Eating disorders (EDs) are liable to alter the disease course of bipolar disorder (BD). We explored the crossed clinical features between EDs and BD, particularly as a function of BD type (BD1 vs. BD2). Methods: 2929 outpatients attending FondaMental Advanced Centers of Expertise were assessed for BD and lifetime EDs with a semi-structured interview, and their sociodemographic, dimensional and clinical data were collected according to a standardized procedure. For each ED type, bivariate analyses were used to investigate associations between these variables and the type of BD type followed by multinomial regressions with the variables associated with EDs and BDs after Bonferroni correction. Results: Comorbid EDs were diagnosed in 478 (16.4 %) cases, and were more prevalent in patients with BD2 than in those with BD1 (20.6 % vs. 12.4 %, p < 0.001). Regression models showed no difference according to the subtype of bipolar disorder on the characteristics of patients with anorexia nervosa (AN), bulimia nervosa (BN) or binge eating disorder (BED). After multiple adjustments, the factors differentiating BD patients with versus without ED were primarily age, gender, body mass index, more affective lability and comorbidity with anxiety disorders. BD patients with BED also scored higher regarding childhood trauma. BD patients with AN also showed higher risk of past suicide attempts than those with BED. Conclusions: In a large sample of patients with BD, we found a high prevalence of lifetime EDs, especially for the BD2 type. EDs were associated with several severity indicators, but not with BD type-specific characteristics. This should prompt clinicians to carefully screen patients with BD for EDs, regardless of BD and ED types.

Published
2023

28. Clinical and biological features associated to bipolar disorder with comorbid migraine: results from the FACE-BD cohort

Author

Patoz, M.-C., primary, Godin, O., additional, Moisset, X., additional, Chabert, J., additional, M’Bailara, K., additional, Etain, B., additional, Belzeaux, R., additional, Dubertret, C., additional, Haffen, E., additional, Schwan, R., additional, Roux, P., additional, Polosan, M., additional, Aubin, V., additional, Leboyer, M., additional, Courtet, P., additional, Olie, E., additional, Llorca, P.-M., additional, and Samalin, L., additional

Published
2023
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30. Substance use disorders in bipolar patients with a painful expression

Author

Chabert, J., primary, Icick, R., additional, Cabé, J., additional, Patoz, M.-C., additional, Moisset, X., additional, Godin, O., additional, Gard, S., additional, Loftus, J., additional, Aubin, V., additional, Belzeaux, R., additional, Dubertret, C., additional, Lestrat, Y., additional, Mazer, N., additional, De Premorel, A., additional, Roux, P., additional, Polosan, M., additional, Schwitzer, T., additional, Aouizerate, B., additional, Isabelle, B., additional, Etain, B., additional, Moirand, R., additional, Olié, E., additional, Haffen, E., additional, Leboyer, M., additional, Courtet, P., additional, Llorca, P.-M., additional, Brousse, G., additional, and Samalin, L., additional

Published
2023
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33. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Andreassen, O.A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R.H., Berk, M., Bjella, T.D., Bossini, L., Bersudsky, Y., Cheung, E.Y.W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M.A., Fountoulakis, K.N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsä, E.T., Kapczinski, F., Kliwicki, S., König, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E.R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F.G., O’Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J.K., Sagduyu, K., Scippa, A.M., Severus, E., Simhandl, C., Stein, D.J., Strejilevich, S., Hatim Sulaiman, A., Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M.J., Zetin, M., and Whybrow, P.C.

Published
2015
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35. Validation of a data collection set for the psychiatric, addiction, sleep and chronobiological assessments of patients with depression: A Delphi study for the SoPsy-depression French national cohort

Author

Geoffroy, P.A., primary, Schroder, C.M., additional, Bourgin, P., additional, Maruani, J., additional, Lejoyeux, M., additional, d’Ortho, M.-P., additional, Couffignal, C., additional, Philip, P., additional, Arnulf, I., additional, Royant-Parola, S., additional, Leger, D., additional, Gohier, B., additional, Gagnadoux, F., additional, Amad, A., additional, Poirot, I., additional, Gaillard, R., additional, Limosin, F., additional, Delorme, R., additional, Jardri, R., additional, Fossati, P., additional, Dubertret, C., additional, Rolland, B., additional, Etain, B., additional, Vorspan, F., additional, Aouizerate, B., additional, Courtet, P., additional, Castroman, J.L., additional, Haffen, E., additional, Drapier, D., additional, Dereux, A., additional, Schwan, R., additional, Luquiens, A., additional, Abril, B., additional, Auriacombe, M., additional, Benyamina, A., additional, Lopez, R., additional, Grall-Bronnec, M., additional, Bennabi, D., additional, Frija-Masson, J., additional, Micoulaud Franchi, J.-A., additional, Schwitzer, T., additional, Maranci, J.-B., additional, and Huck, U.K., additional

Published
2022
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37. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Author

Culverhouse, R C, Saccone, N L, Horton, A C, Ma, Y, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Burns, R, Byrne, E M, Coffey, C, Coventry, W L, Gawronski, K AB, Glei, D, Hatzimanolis, A, Hottenga, J-J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Little, K, zu Schwabedissen, H M, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Stacey, D, Tian, Y, Toben, C, Van der Auwera, S, Wainwright, N, Wang, J-C, Willemsen, G, Anderson, I M, Arolt, V, Åslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, de Geus, E JC, Deakin, J FW, Easteal, S, Eley, T, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Johnson, E O, Kennedy, M, Laucht, M, Martin, N G, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B WJH, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Smit, J H, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M, Nurnberger, J I, Jr, Breslau, N, and Bierut, L J

Published
2018
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38. Solar insolation in springtime influences age of onset of bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Aleksandrovich, M. A., Andreassen, O. A., Angelopoulos, E., Ardau, R., Ayhan, Y., Baethge, C., Bharathram, S. R., Bauer, R., Baune, B. T., Becerra‐Palars, C., Bellivier, F., Belmaker, R. H., Berk, M., Bersudsky, Y., Bicakci, Ş., Birabwa‐Oketcho, H., Bjella, T. D., Bossini, L., Cabrera, J., Cheung, E. Y. W., Del Zompo, M., Dodd, S., Donix, M., Etain, B., Fagiolini, A., Fountoulakis, K. N., Frye, M. A., Gonzalez‐Pinto, A., Gottlieb, J. F., Grof, P., Harima, H., Henry, C., Isometsä, E. T., Janno, S., Kapczinski, F., Kardell, M., Khaldi, S., Kliwicki, S., König, B., Kot, T. L., Krogh, R., Kunz, M., Lafer, B., Landén, M., Larsen, E. R., Lewitzka, U., Licht, R. W., Lopez‐Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez‐Cengotitabengoa, M., Melle, I., Meza‐Urzúa, F., Yee Ming, M., Monteith, S., Morken, G., Mosca, E., Munoz, R., Mythri, S. V., Nacef, F., Nadella, R. K., Nery, F. G., Nielsen, R. E., OʼDonovan, C., Omrani, A., Osher, Y., Østermark Sørensen, H., Ouali, U., Pica Ruiz, Y., Pilhatsch, M., Pinna, M., da Ponte, F. D. R., Quiroz, D., Ramesar, R., Rasgon, N., Reddy, M. S., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, Â. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Subramaniam, M., Sulaiman, A. H., Suominen, K., Tagata, H., Tatebayashi, Y., Tondo, L., Torrent, C., Vaaler, A. E., Veeh, J., Vieta, E., Viswanath, B., Yoldi‐Negrete, M., Zetin, M., Zgueb, Y., and Whybrow, P. C.

Published
2017
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39. Key findings on bipolar disorders from the longitudinal FondaMental Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort

Author

Leboyer, M., primary, Godin, O., additional, Llorca, P.M., additional, Aubin, V., additional, Bellivier, F., additional, Belzeaux, R., additional, Courtet, P., additional, Costagliola, D., additional, Dubertret, C., additional, M'Bailara, K., additional, Haffen, E., additional, Henry, C., additional, Laouamri, H., additional, Passerieux, C., additional, Pelletier, A., additional, Polosan, M., additional, Roux, P., additional, Schwan, R., additional, Samalin, L., additional, Olié, E., additional, Etain, Bruno, additional, Etain, B., additional, Leboyer, M., additional, Barteau, V., additional, Bensalem, S., additional, Souryis, K., additional, Hotier, S., additional, Sanchez, J.P., additional, Saliou, E., additional, Hebbache, C., additional, Petrucci, J., additional, Wuillaume, L., additional, Bourdin, E., additional, Carminati, M., additional, Hennion, V., additional, Marlinge, E., additional, Meheust, J., additional, Zekri, C., additional, Desage, A., additional, Gard, S., additional, Minois, I., additional, Sportich, J., additional, Zanouy, L., additional, Abettan, C., additional, Bardin, L., additional, Cazals, A., additional, Deffinis, B., additional, Ducasse, D., additional, Gachet, M., additional, Henrion, A., additional, Martinerie, E., additional, Molière, F., additional, Noisette, B., additional, and Tarquini, E.G., additional

Published
2022
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42. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Author

Blokland, G.A., Grove, J, Chen, C.Y., Cotsapas, C., Tobet, S., Handa, R., Clair, D. St, Lencz, T., Mowry, B.J., Periyasamy, S., Cairns, M.J., Tooney, P.A., Wu, J.Q., Kelly, B., Kirov, G., Sullivan, P.F., Corvin, A., Riley, B.P., Esko, T., Milani, L., Jönsson, E.G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P.C., Iwata, N., Weinberger, D.R., Gejman, P.V., Sanders, A.R., Buxbaum, J.D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A.M., Bramon, E., Murray, R.M., Pato, M.T., Lee, J., Melle, I., Molden, E., Ophoff, R.A., McQuillin, A., Bass, N.J., Adolfsson, R., Malhotra, A.K., Martin, N.G., Fullerton, J.M., Mitchell, P.B., Schofield, P.R., Forstner, A.J., Degenhardt, F., Schaupp, S., Comes, A.L., Kogevinas, M., Guzman-Parra, J., Reif, A., Streit, F., Sirignano, L., Cichon, S., Grigoroiu-Serbanescu, M., Hauser, J., Lissowska, J., Mayoral, F., Müller-Myhsok, B., Świątkowska, B., Schulze, T.G., Nöthen, M.M., Rietschel, M., Kelsoe, J., Leboyer, M., Jamain, S., Etain, B., Bellivier, F., Vincent, J.B., Alda, M., O'Donovan, C., Cervantes, P., Biernacka, J.M., Frye, M., McElroy, S.L., Scott, L.J., Stahl, E.A., Landén, M., Hamshere, M.L., Smeland, O.B., Djurovic, S., Vaaler, A.E., Andreassen, O.A., Baune, B.T., Air, T., Preisig, M., Uher, R., Levinson, D.F., Weissman, M.M., Potash, J.B., Shi, J., Knowles, J.A., Bralten, J.B., Perlis, R.H., Lucae, S., Blokland, G.A., Grove, J, Chen, C.Y., Cotsapas, C., Tobet, S., Handa, R., Clair, D. St, Lencz, T., Mowry, B.J., Periyasamy, S., Cairns, M.J., Tooney, P.A., Wu, J.Q., Kelly, B., Kirov, G., Sullivan, P.F., Corvin, A., Riley, B.P., Esko, T., Milani, L., Jönsson, E.G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P.C., Iwata, N., Weinberger, D.R., Gejman, P.V., Sanders, A.R., Buxbaum, J.D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A.M., Bramon, E., Murray, R.M., Pato, M.T., Lee, J., Melle, I., Molden, E., Ophoff, R.A., McQuillin, A., Bass, N.J., Adolfsson, R., Malhotra, A.K., Martin, N.G., Fullerton, J.M., Mitchell, P.B., Schofield, P.R., Forstner, A.J., Degenhardt, F., Schaupp, S., Comes, A.L., Kogevinas, M., Guzman-Parra, J., Reif, A., Streit, F., Sirignano, L., Cichon, S., Grigoroiu-Serbanescu, M., Hauser, J., Lissowska, J., Mayoral, F., Müller-Myhsok, B., Świątkowska, B., Schulze, T.G., Nöthen, M.M., Rietschel, M., Kelsoe, J., Leboyer, M., Jamain, S., Etain, B., Bellivier, F., Vincent, J.B., Alda, M., O'Donovan, C., Cervantes, P., Biernacka, J.M., Frye, M., McElroy, S.L., Scott, L.J., Stahl, E.A., Landén, M., Hamshere, M.L., Smeland, O.B., Djurovic, S., Vaaler, A.E., Andreassen, O.A., Baune, B.T., Air, T., Preisig, M., Uher, R., Levinson, D.F., Weissman, M.M., Potash, J.B., Shi, J., Knowles, J.A., Bralten, J.B., Perlis, R.H., and Lucae, S.

Abstract

Item does not contain fulltext, BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. RESULTS: Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10(-8)), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10(-6)) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10(-7); rs73033497, p = 8.8 × 10(-7); rs7914279, p = 6.4 × 10(-7)), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10(-7)) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10(-7)), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10(-7)) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). CONCLUSIONS: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and

Published
2022

43. Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative

Author

Burdick, KE, Millett, CE, Yocum, AK, Altimus, CM, Andreassen, OA, Aubin, V, Belzeaux, R, Berk, Michael, Biernacka, JM, Blumberg, HP, Cleare, AJ, Diaz‐Byrd, C, Dubertret, C, Etain, B, Eyler, L, Forester, BP, Fullerton, JM, Frye, MA, Gard, S, Godin, O, Haffen, E, Klaus, F, Lagerberg, TV, Leboyer, M, Martinez‐Aran, A, McElroy, S, Mitchell, PB, Olie, E, Olorunfemi, P, Passerieux, C, Peters, A, Pham, DL, Polosan, M, Potter, JR, Sajatovic, M, Samalin, L, Schwan, R, Shanahan, M, Solé, B, Strawbridge, R, Stuart, Amanda, Torres, I, Ueland, T, Vieta, E, Williams, Lana, Wrobel, Anna, Yatham, LN, Young, AH, Nierenberg, A, McInnis, MG, Burdick, KE, Millett, CE, Yocum, AK, Altimus, CM, Andreassen, OA, Aubin, V, Belzeaux, R, Berk, Michael, Biernacka, JM, Blumberg, HP, Cleare, AJ, Diaz‐Byrd, C, Dubertret, C, Etain, B, Eyler, L, Forester, BP, Fullerton, JM, Frye, MA, Gard, S, Godin, O, Haffen, E, Klaus, F, Lagerberg, TV, Leboyer, M, Martinez‐Aran, A, McElroy, S, Mitchell, PB, Olie, E, Olorunfemi, P, Passerieux, C, Peters, A, Pham, DL, Polosan, M, Potter, JR, Sajatovic, M, Samalin, L, Schwan, R, Shanahan, M, Solé, B, Strawbridge, R, Stuart, Amanda, Torres, I, Ueland, T, Vieta, E, Williams, Lana, Wrobel, Anna, Yatham, LN, Young, AH, Nierenberg, A, and McInnis, MG

Published
2022

44. Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology

Author

McCarthy, MJ, Gottlieb, JF, Gonzalez, R, McClung, CA, Alloy, LB, Cain, S, Dulcis, D, Etain, B, Frey, BN, Garbazza, C, Ketchesin, KD, Landgraf, D, Lee, H-J, Marie-Claire, C, Nusslock, R, Porcu, A, Porter, R, Ritter, P, Scott, J, Smith, D, Swartz, HA, Murray, G, McCarthy, MJ, Gottlieb, JF, Gonzalez, R, McClung, CA, Alloy, LB, Cain, S, Dulcis, D, Etain, B, Frey, BN, Garbazza, C, Ketchesin, KD, Landgraf, D, Lee, H-J, Marie-Claire, C, Nusslock, R, Porcu, A, Porter, R, Ritter, P, Scott, J, Smith, D, Swartz, HA, and Murray, G

Abstract

AIM: Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. METHOD: Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. RESULTS: Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. CONCLUSIONS: Future research in circadian rhythms and its role in BD is warranted. Well-powered studies that carefully define associations between BD-related and chronobiologically-related constructs, and integrate across levels of analysis will be most illuminating.

Published
2022

45. Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.

Author

Reininghaus, EZ, Manchia, M, Dalkner, N, Bonkat, N, Squassina, A, Hodl, I, Vieta, E, Reif, A, Hajek, T, Landén, M, Correll, CU, Scott, J, Etain, B, Rietschel, M, Bergink, V, Martinez-Cengotitabengoa, M, Kessing, LV, Fagiolini, A, Bauer, M, Goodwin, G, Gonzalez-Pinto, A, Kupka, RW, Schulze, TG, Lagerberg, TV, Yildiz, A, Henry, C, Morken, G, Ritter, P, Nieslen, RE, Licht, RW, Bechdolf, A, Andreassen, OA, Fellendorf, FT, Reininghaus, EZ, Manchia, M, Dalkner, N, Bonkat, N, Squassina, A, Hodl, I, Vieta, E, Reif, A, Hajek, T, Landén, M, Correll, CU, Scott, J, Etain, B, Rietschel, M, Bergink, V, Martinez-Cengotitabengoa, M, Kessing, LV, Fagiolini, A, Bauer, M, Goodwin, G, Gonzalez-Pinto, A, Kupka, RW, Schulze, TG, Lagerberg, TV, Yildiz, A, Henry, C, Morken, G, Ritter, P, Nieslen, RE, Licht, RW, Bechdolf, A, Andreassen, OA, and Fellendorf, FT

Abstract

Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.

Published
2022

46. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients (vol 12, 278, 2022)

Author

Schubert, KO, Thalamuthu, A, Amare, AT, Frank, J, Streit, F, Adl, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, J-M, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Marie-Claire, C, Cearns, M, Cervantes, P, Chen, H-C, Chillotti, C, Cichon, S, Clark, SR, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, Y-H, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kuo, P-H, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, Konig, B, Kusumi, I, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, S, Colom, F, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nothen, MM, Novak, T, O'Donovan, C, Ozaki, N, Osby, U, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Squassina, A, Stamm, T, Stopkova, P, Tekola-Ayele, F, Tortorella, A, Turecki, G, Veeh, J, Vieta, E, Witt, SH, Roberts, G, Zandi, PP, Alda, M, Bauer, M, McMahon, FJ, Mitchell, PB, Schulze, TG, Rietschel, M, Baune, BT, Schubert, KO, Thalamuthu, A, Amare, AT, Frank, J, Streit, F, Adl, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, J-M, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Marie-Claire, C, Cearns, M, Cervantes, P, Chen, H-C, Chillotti, C, Cichon, S, Clark, SR, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, Y-H, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kuo, P-H, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, Konig, B, Kusumi, I, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, S, Colom, F, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nothen, MM, Novak, T, O'Donovan, C, Ozaki, N, Osby, U, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Squassina, A, Stamm, T, Stopkova, P, Tekola-Ayele, F, Tortorella, A, Turecki, G, Veeh, J, Vieta, E, Witt, SH, Roberts, G, Zandi, PP, Alda, M, Bauer, M, McMahon, FJ, Mitchell, PB, Schulze, TG, Rietschel, M, and Baune, BT

Published
2022

48. Influence of childhood maltreatment on prevalence, onset and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders

Author

Grillault Laroche, D., Godin, O., Dansou, Y., Belzeaux, R., Aouizerate, B., Burté, T., Courtet, Philippe, Dubertret, C., Haffen, E., Llorca, P.M., Olié, Émilie, Roux, P., Polosan, M., Schwan, R., Leboyer, M., Bellivier, F., Marie-Claire, C., Etain, B., Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor [Créteil], Fondation FondaMental [Créteil], Assistance Publique - Hôpitaux de Marseille (APHM), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier Charles Perrens [Bordeaux], Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Princesse Grace, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université Paris Cité (UPCité), Hôpital Louis Mourier - AP-HP [Colombes], Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Université de Lorraine (UL), Centre Psychothérapique de Nancy [Laxou] (CPN), ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010), Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, Inserm U1266, 178, rue des Renouillers, 92700 Colombes, France, UFR de Médecine Paris Nord, Université de Paris, 16, rue Henri Huchard, 75018 Paris, France., Groupe de Recherche en Psychologie Sociale (GRePS), Université Lumière - Lyon 2 (UL2), Praticien Hospitalier Universitaire, CPN Laxou, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Guerineau, Nathalie C., Sorbonne Universités à Paris pour l'Enseignement et la Recherche - - SUPER2011 - ANR-11-IDEX-0004 - IDEX - VALID, Cohortes - FondaMental-Cohortes - - Psy-COH2010 - ANR-10-COHO-0010 - COHO - VALID, CHU Henri Mondor, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), and Hôpital Charles Perrens

Subjects
bipolar disorder, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, childhood trauma, [SDV]Life Sciences [q-bio], childhood maltreatment, prevalence, substance use, Suicide, Attempted, sequence, anxiety, comorbidities, Suicidal Ideation, [SDV] Life Sciences [q-bio], Psychiatry and Mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, mental disorders, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Child Abuse, Child, network analysis, suicide, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

BackgroundPsychiatric comorbidities and suicide attempts are highly prevalent in Bipolar Disorders (BD). We examined the associations between childhood maltreatment, psychiatric comorbidities, and suicide attempts, in terms of lifetime prevalence, sequence of onset, and current symptoms.MethodsWe assessed 3,047 individuals with BD for suicide attempts, anxiety disorders, substance use disorders, and eating disorders. Participants completed a self-report for the assessment of childhood maltreatment. Associations between childhood maltreatment and characteristics of comorbidities (lifetime prevalence, current symptoms, and age at onset) were examined using logistic regressions and network analyses.ResultsPsychiatric comorbidities were frequent with a mean number per individual of 1.23 (SD = 1.4). Most comorbidities occurred prior to the onset of BD. Participants who reported higher levels of childhood maltreatment had more frequent and multiple comorbidities, which were also more currently active at inclusion. Childhood maltreatment did not decrease the age of onset of comorbidities, but was associated with a faster accumulation of comorbidities prior to the onset of BD. Logistic regression and network analyses showed that emotional abuse and sexual abuse might play a prominent role in the lifetime prevalence of psychiatric comorbidities and suicide attempts.ConclusionsChildhood maltreatment was associated with suicide attempts, and with frequent, multiple, and persistent psychiatric comorbidities that accumulated more rapidly prior to the onset of BD. Hence, childhood maltreatment should be systematically assessed in individuals with BD, in particular when the course of the disorder is characterized by a high comorbid profile or by a high suicidality.

Published
2022

50. Letter of response to Nabi Z, Stansfeld J, Plöderl M, Wood L, Moncrieff J. Effects of lithium on suicide and suicidal behaviour: a systematic review and meta-analysis of randomised trials. Epidemiol Psychiatr Sci. 2022 Sep 16;31:e65. doi: 10.1017/S204579602200049X

Author

Bschor, T, primary, Adli, M, additional, Alda, M, additional, Baethge, C, additional, Etain, B, additional, Glenn, T, additional, Grof, P, additional, Hajek, T, additional, Hayes, J, additional, Manchia, M, additional, Müller-Oerlinghausen, B, additional, Nielsen, RE, additional, Ritter, P, additional, Rybakowski, JK, additional, Sani, G, additional, Selo, ML, additional, Young, AH, additional, and Tondo, L, additional

Published
2022
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