1,765 results on '"Esthesioneuroblastoma"'
Search Results
2. Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).
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- 2024
3. 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. (DOMINO-START)
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Novartis Pharmaceuticals
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- 2024
4. Recurrence morbidity of olfactory neuroblastoma.
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Melder, Katie, Mace, Jess C., Choby, Garret, Almeida, Joao Paulo, Champagne, Pierre‐Olivier, Chan, Erik, Ciporen, Jeremy, Chaskes, Mark B., Fernandez‐Miranda, Juan, Fung, Nicholas K., Gardner, Paul, Hwang, Peter, Ji, Keven Seung Yong, Kalyvas, Aristotelis, Kong, Keonho A., Patel, Chirag, Patel, Zara, Celda, Maria Peris, Pinheiro‐Neto, Carlos D., and Snyderman, Carl
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SKULL base , *OVERALL survival , *TUMOR classification , *NEUROBLASTOMA , *STANDARD deviations - Abstract
Background: With modern treatment paradigms, olfactory neuroblastoma (ONB) has favorable overall survival (OS); however, the incidence of recurrence remains high. The primary aims of this study were to delineate the prognosis of recurrence of ONB and explore how recurrence subsites are associated with OS, disease‐specific survival (DSS), and further recurrence. Methods: A retrospective chart review of ONB cases from nine academic centers between 2005 and 2021 was completed. Tumor characteristics, recurrence subsites, timelines to recurrence, additional recurrences, and survival estimates were determined using descriptive and time‐to‐event analyses. Results: A final cohort of 233 patients was identified, with 70 (30.0%) patients recurring within 50.4 (standard deviation ±40.9) months of diagnosis on average, consisting of local (50%), neck (36%), intracranial (9%), and distant (6%) recurrence. Compared with subjects without recurrence, patients with recurrence had significantly different primary American Joint Committee on Cancer T stage (p < 0.001), overall stage (p < 0.001), and modified Kadish scores (p < 0.001). Histopathology identified that dural involvement and positive margins were significantly greater in recurrent cases. First recurrence was significantly associated with worse 5‐year DSS (hazard ratio = 5.62; p = 0.003), and subjects with neck or local recurrence had a significantly better DSS compared to intracranial or distant recurrence. Conclusions: Recurrent cases of ONB have significantly different stages and preoperative imaging factors. Patients with local or neck recurrence, however, have better DSS than those with intracranial or distant recurrence, independent of initial tumor stage or Hyams grade. Identifying specific factors that confer an increased risk of recurrence and DSS is important for patient counseling in addition to surveillance planning. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Computed tomographic findings of a nasal neuroendocrine neoplasm with intracranial extension in a horse.
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Giorio, Maria Elisabetta, Mitchell, Jordan L., Priestnall, Simon L., Dunkel, Bettina, Dash, Rupert F., and Berner, Dagmar
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NEUROENDOCRINE tumors , *CRIBRIFORM plate , *HORSE sports , *COMPUTED tomography , *INTRACRANIAL tumors , *PTERYGOPALATINE ganglion - Abstract
Summary A 20‐year‐old Irish Sport Horse gelding was presented to the Royal Veterinary College Equine Referral Hospital for investigation of left‐sided epistaxis, depression and gait abnormalities of approximately 1 month duration. Physical examination and cranial nerve evaluation were unremarkable. A small amount of haemorrhagic discharge was noted from the left nostril. Gait evaluation was suggestive of proprioceptive deficits. Computed tomography (CT) identified a mass lesion within the left conchofrontal and sphenopalatine sinuses extending through the cribriform plate into the calvarium. Histopathology of the mass revealed a neuroendocrine neoplasm, for which a diagnosis of esthesioneuroblastoma was favoured. This case highlights the usefulness of CT for the identification and extent of an intracranial mass and therefore its prognosis, however, histopathological examination was necessary to confirm the diagnosis. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Clinical Outcome in Patients with Large Sinonasal Tumors with Intracranial Extension.
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Keizer, Max E., Hovinga, Koos E., Lacko, Martin, Eekers, Danielle B.P., Baijens, Laura W.J., Kremer, Bernd, and Temel, Yasin
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TREATMENT effectiveness , *INTRACRANIAL tumors , *PROGRESSION-free survival , *PARANASAL sinuses , *DISTRIBUTION (Probability theory) - Abstract
Objectives Malignant tumors of the sinonasal cavities with extension to the frontal skull base are rare and challenging pathologies. Combined-approach surgery using a frontobasal craniotomy and endoscopic sinus surgery with reconstruction of the anterior skull base followed by adjuvant radiotherapy is a preferred treatment strategy in selected cases. Morbidity and mortality rates are high in this population. We aim to add our experience to the current literature. Design We performed a retrospective cross-sectional single center study of the long-term clinical outcome in a tertiary university referral hospital in the Netherlands between 2010 and 2021. Descriptive statistics and frequency distributions were performed Participants Patient, tumor, treatment, complications and survival characteristics of eighteen consecutive patients were extracted from the electronic health records. Main Outcome Measures The primary outcome measures are progression free survival, overall survival and complication rate. Results Eighteen consecutive patients were included with a mean age of 61 (SD ± 10) years (range 38-80); ten males and eight females. Gross total resection was achieved in 14 (77%) patients. Eleven (61%) patients underwent local radiotherapy, one (5%) chemotherapy and three (17%) a combination of both. Mean follow-up duration was 49 months (range 3 – 138). Three (17%) patients died in hospital due to post-operative complications. Six (33%) patients died during follow-up due to disease progression. Mean progression-free survival was 47 months (range 0 – 113). Conclusion In conclusion, the overall survival was 50% for this group of patients with large sinonasal tumors. Progressive disease affects survival rate severely. Surgical complications were seen in five (28%) patients. Radiotherapy is associated with high complication rates. Radiation necrosis was a serious complication in two patients and could be treated with high dose steroids. [ABSTRACT FROM AUTHOR]
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- 2024
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7. SNOT‐22 subdomain outcomes following treatment for sinonasal malignancy: A prospective, multicenter study.
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Grimm, David R., Beswick, Daniel M., Maoz, Sabrina L., Wang, Eric W., Choby, Garret W., Kuan, Edward C., Chan, Erik P., Adappa, Nithin D., Geltzeiler, Mathew, Getz, Anne E., Humphreys, Ian M., Le, Christopher H., Abuzeid, Waleed M., Chang, Eugene H., Jafari, Aria, Kingdom, Todd T., Kohanski, Michael A., Lee, Jivianne K., Nayak, Jayakar V., and Palmer, James N.
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Background: Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22‐item Sinonasal Outcomes Test (SNOT‐22) has been shown to improve with treatment. This study aims to characterize SNOT‐22 subdomain outcomes in SNM. Methods: Patients diagnosed with SNM were prospectively enrolled in a multi‐center patient registry. SNOT‐22 scores were collected at the time of diagnosis and through the post‐treatment period for up to 5 years. Multivariable regression analysis was used to identify drivers of variation in SNOT‐22 subdomains. Results: Note that 234 patients were reviewed, with a mean follow‐up of 22 months (3 months–64 months). Rhinologic, psychological, and sleep subdomains significantly improved versus baseline (all p < 0.05). Subanalysis of 40 patients with follow‐up at all timepoints showed statistically significant improvement in rhinologic, extra‐nasal, psychological, and sleep subdomains, with minimal clinically important difference met between 2 and 5 years in sleep and psychological subdomains. Adjuvant chemoradiation was associated with worse outcomes in rhinologic (adjusted odds ratio (5.22 [1.69–8.66])), extra‐nasal (2.21 [0.22–4.17]) and ear/facial (5.53 [2.10–8.91]) subdomains. Pterygopalatine fossa involvement was associated with worse outcomes in rhinologic (3.22 [0.54–5.93]) and ear/facial (2.97 [0.32–5.65]) subdomains. Positive margins (5.74 [2.17–9.29]) and surgical approach—combined versus endoscopic (3.41 [0.78–6.05])—were associated with worse psychological outcomes. Adjuvant radiation (2.28 [0.18–4.40]) was associated with worse sleep outcomes. Conclusions: Sinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra‐nasal, psychological, and sleep subdomains. [ABSTRACT FROM AUTHOR]
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- 2024
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8. OLFACTORY NEUROBLASTOMA WITH INTRACRANIAL EXTENSION.
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Putra Romadhoni, Andry Nurwahyu, Imanuddin, Iqbal, Tejomukti, Teddy, Yasuhiro Watanabe, Takenobu Murakami, and Tajir, Yuki
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OLFACTORY esthesioneuroblastoma , *NOSEBLEED , *CANCER chemotherapy , *EARLY diagnosis , *IMMUNOHISTOCHEMISTRY , *HISTOPATHOLOGY - Abstract
Background: Olfactory Neuroblastoma (ONB), so called esthesioneuroblastoma, is a rare malignant tumor of the sinonasal tract. ONB represents 6.3% of all sinonasal tract malignancies, with a prevalence of 0.4 cases per million population. These tumors are slowgrowing and there may be intracranial extension of the tumor. Nasal obstruction, anosmia, recurrent epistaxis and pain are typical early manifestations. Imaging studies are essential in determining tumor extension and surgical planning of ONB. Endonasal biopsy is required to confirm the diagnosis of ONB. The case provides a basis for discussion of ONB and highlights the possibility of extension of this tumor. Case: A 45-year-old male presented with a generalized clonic seizure, conjugate eye deviation, and pre-seizure headache. Post-seizure, the patient was unconscious and incontinent, later appearing conscious but confused. The patient had a history of seizures at home and in the ER, along with occasional headaches over the past year. The patient described nasal congestion, decreased smell, and recurrent nosebleeds, having undergone ethmoidectomy in 2020 for papilloma. Discussion: The patient experienced symptoms of seizures, headache, and nasal disturbances. Olfactory neuroblastoma (ONB) tumor was detected after comprehensive examination. Treatment involves multimodal therapy, including surgery, chemotherapy, and radiotherapy, with prognosis depending on tumor stage and grade. Conclusion: Early diagnosis of ONB is necessary to prevent further tumor progression. Intracranial extension of the ONB should be carefully investigated. Imaging as well as histopathological and immunohistochemical examinations are very helpful in identifying the location, metastasis and degree of malignancy of the tumor. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Sinonasal Tumors: Clinical and Morphological Characteristics and Differential Diagnosis
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A. I. Prokhorova, S. I. Samoylova, O. A. Levendyuk, M. I. Didenko, I. V. Reshetov, N. S. Sukortseva, O. V. Samoilova, and T. A. Demura
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small round blue cell tumors ,sinonasal neuroendocrine carcinoma ,esthesioneuroblastoma ,olfactory neuroblastoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Malignant sinonasal tumors are rare and account for 1% of all neoplasms. Most of these carcinomas are poorly differentiated or undifferentiated tumors. Due to overlapping features, both young and experienced physicians encounter difficulties in their diagnosis. We present 2 cases of 2 tumors of the sinonasal tract, which belong to small round blue cell tumors: sinonasal small cell neuroendocrine tumor and esthesioneuroblastoma.
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- 2024
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10. Long-Term Longitudinal QoL in Patients Undergoing EEA
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Kyle Wu, Assistant Professor, Neurological Surgery
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- 2023
11. DOTATATE PET Imaging in Olfactory Neuroblastoma and Association with SSTR Expression.
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Palmieri, Daniel E., Tadokoro, Kent S., Valappil, Benita, Pakala, Theja, Muthukrishnan, Ashok, Seethala, Raja R., and Snyderman, Carl H.
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RADIONUCLIDE imaging , *POSITRON emission tomography , *NASAL tumors , *SOMATOSTATIN receptors , *NASAL cavity , *RHINORRHEA , *SKULL base - Abstract
Introduction Olfactory neuroblastoma (ONB), or esthesioneuroblastoma, is a rare neuroectodermal tumor of the nasal cavity and paranasal sinuses. Most of these tumors express somatostatin receptors (SSTRs), providing a potential target for radionuclide imaging with Ga-68 DOTATATE. However, this imaging modality has not been extensively studied in ONB. Methods We conducted a retrospective chart review of 96 endoscopic endonasal skull base surgery cases for ONB performed at our institution between 2000 and 2021. Histo (H) scores were assigned to each tumor and normalized DOTATATE standardized uptake values (nSUVs) were measured as well. Results Nine patients (5 males and 4 females) with ONB were ultimately included in the study. The average age of the patients was 50 years. All ONBs had a positive SSTR2 expression (H-score > 105; mean: 180). All ONBs showed DOTATATE avidity (mean nSUV for ONB: 6.7). However, there was no correlation between H-score and nSUV, with an r2 of 0.24 (p = 0.18). Conclusion Our study shows that SSTR2 expression is found in all ONBs with associated DOTATATE avidity, which may serve as a valuable imaging modality to monitor for recurrent and metastatic disease in ONB. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Treatment Outcomes of Olfactory Neuroblastoma: A Multicenter Study by the Korean Sinonasal Tumor and Skull Base Surgery Study Group
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Sang Duk Hong, Song I Park, Ji Heui Kim, Sung Jae Heo, Sung-Woo Cho, Tae-Bin Won, Hyun-Jin Cho, Dong Hoon Lee, Sue Jean Mun, Soo Kyoung Park, Yong-Wan Kim, and Dong-Young Kim
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esthesioneuroblastoma ,neoadjuvant therapy ,prognosis ,treatment outcome ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives. Due to the rarity of olfactory neuroblastoma (ONB), there is ongoing debate about optimal treatment strategies, especially for early-stage or locally advanced cases. Therefore, our study aimed to explore experiences from multiple centers to identify factors that influence the oncological outcomes of ONB. Methods. We retrospectively analyzed 195 ONB patients treated at nine tertiary hospitals in South Korea between December 1992 and December 2019. Kaplan-Meier survival analysis was used to evaluate oncological outcomes, and a Cox proportional hazards regression model was employed to analyze prognostic factors for survival outcomes. Furthermore, we conducted 1:1 nearest-neighbor matching to investigate differences in clinical outcomes according to the use of neoadjuvant chemotherapy. Results. In our cohort, the 5-year overall survival (OS) rate was 78.6%, and the 5-year disease-free survival (DFS) rate was 62.4%. The Cox proportional hazards model revealed that the modified Kadish (mKadish) stage and Dulguerov T status were significantly associated with DFS, while the mKadish stage and Hyams grade were identified as prognostic factors for OS. The subgroup analyses indicated a trend toward improved 5-year DFS with dural resection in mKadish A and B cases, even though the result was statistically insignificant. Induction chemotherapy did not provide a survival benefit in this study after matching for the mKadish stage and nodal status. Conclusion. Clinical staging and pathologic grading are important prognostic factors in ONB. Dural resection in mKadish A and B did not show a significant survival benefit. Similarly, induction chemotherapy also did not show a survival benefit, even after stage matching.
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- 2024
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13. Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses
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Riley M. Larkin, Diana C. Lopez, Yvette L. Robbins, Wiem Lassoued, Kenneth Canubas, Andrew Warner, Baktiar Karim, Ksenia Vulikh, James W. Hodge, Charalampos S. Floudas, James L. Gulley, Gary L. Gallia, Clint T. Allen, and Nyall R. London
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Esthesioneuroblastoma ,Immunotherapy ,Olfactory neuroblastoma ,Medicine - Abstract
Abstract Background Olfactory neuroblastoma is a rare malignancy of the anterior skull base typically treated with surgery and adjuvant radiation. Although outcomes are fair for low-grade disease, patients with high-grade, recurrent, or metastatic disease oftentimes respond poorly to standard treatment methods. We hypothesized that an in-depth evaluation of the olfactory neuroblastoma tumor immune microenvironment would identify mechanisms of immune evasion in high-grade olfactory neuroblastoma as well as rational targetable mechanisms for future translational immunotherapeutic approaches. Methods Multispectral immunofluorescence and RNAScope evaluation of the tumor immune microenvironment was performed on forty-seven clinically annotated olfactory neuroblastoma samples. A retrospective chart review was performed and clinical correlations assessed. Results A significant T cell infiltration was noted in olfactory neuroblastoma samples with a stromal predilection, presence of myeloid-derived suppressor cells, and sparse natural killer cells. A striking decrease was observed in MHC-I expression in high-grade olfactory neuroblastoma compared to low-grade disease, representing a mechanism of immune evasion in high-grade disease. Mechanistically, the immune effector stromal predilection appears driven by low tumor cell MHC class II (HLA-DR), CXCL9, and CXCL10 expression as those tumors with increased tumor cell expression of each of these mediators correlated with significant increases in T cell infiltration. Conclusion These data suggest that immunotherapeutic strategies that augment tumor cell expression of MHC class II, CXCL9, and CXCL10 may improve parenchymal trafficking of immune effector cells in olfactory neuroblastoma and augment immunotherapeutic responses.
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- 2024
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14. Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses.
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Larkin, Riley M., Lopez, Diana C., Robbins, Yvette L., Lassoued, Wiem, Canubas, Kenneth, Warner, Andrew, Karim, Baktiar, Vulikh, Ksenia, Hodge, James W., Floudas, Charalampos S., Gulley, James L., Gallia, Gary L., Allen, Clint T., and London Jr., Nyall R.
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NEUROBLASTOMA , *MYELOID-derived suppressor cells , *KILLER cells , *HLA-DR antigens , *CHEMOKINES , *SKULL base - Abstract
Background: Olfactory neuroblastoma is a rare malignancy of the anterior skull base typically treated with surgery and adjuvant radiation. Although outcomes are fair for low-grade disease, patients with high-grade, recurrent, or metastatic disease oftentimes respond poorly to standard treatment methods. We hypothesized that an in-depth evaluation of the olfactory neuroblastoma tumor immune microenvironment would identify mechanisms of immune evasion in high-grade olfactory neuroblastoma as well as rational targetable mechanisms for future translational immunotherapeutic approaches. Methods: Multispectral immunofluorescence and RNAScope evaluation of the tumor immune microenvironment was performed on forty-seven clinically annotated olfactory neuroblastoma samples. A retrospective chart review was performed and clinical correlations assessed. Results: A significant T cell infiltration was noted in olfactory neuroblastoma samples with a stromal predilection, presence of myeloid-derived suppressor cells, and sparse natural killer cells. A striking decrease was observed in MHC-I expression in high-grade olfactory neuroblastoma compared to low-grade disease, representing a mechanism of immune evasion in high-grade disease. Mechanistically, the immune effector stromal predilection appears driven by low tumor cell MHC class II (HLA-DR), CXCL9, and CXCL10 expression as those tumors with increased tumor cell expression of each of these mediators correlated with significant increases in T cell infiltration. Conclusion: These data suggest that immunotherapeutic strategies that augment tumor cell expression of MHC class II, CXCL9, and CXCL10 may improve parenchymal trafficking of immune effector cells in olfactory neuroblastoma and augment immunotherapeutic responses. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Clinical outcomes for olfactory neuroblastoma.
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Akira Nakazono, Hiroaki Motegi, Masanobu Suzuki, Yuji Nakamaru, Shigeru Yamaguchi, Yukitomo Ishi, Satoshi Kano, Nayuta Tsushima, Aya Honma, Takayoshi Suzuki, Shogo Kimura, Seijiro Hamada, Jun Taguchi, Yasushi Shimizu, Takashi Mori, Koichi Yasuda, Hidefumi Aoyama, Ichiro Kinoshita, Miki Fujimura, and Akihiro Homma
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SKULL surgery ,ENDOSCOPIC surgery ,TREATMENT effectiveness ,NEUROBLASTOMA ,SKULL base ,INDUCTION chemotherapy ,CRANIOTOMY ,SMELL disorders ,RADIOTHERAPY - Abstract
Background: Olfactory neuroblastoma (ONB) is a rare malignant tumor arising from the olfactory neuroepithelium. The standard of care for ONB is surgical resection; however, detailed treatment protocols vary by institution. Our treatment protocol consists of endoscopic skull base surgery (ESBS) for endoscopically resectable cases and induction chemotherapy followed by craniotomy combined with ESBS for locally advanced cases, with postoperative radiotherapy performed for all cases. Chemoradiotherapy (CRT) is performed in unresectable cases. In this study, we evaluate our treatment protocol and outcomes for ONB. Methods: A retrospective review of patients with ONB was conducted. Outcomes included survival outcomes and perioperative data. Results: Fifteen patients (53.6%) underwent ESBS, 12 (42.9%) underwent craniotomy combined with ESBS, and 1 (3.6%) received CRT. The 5- and 10-year overall survival rates for all patients were 92.9% and 82.5%, respectively, with a median follow-up period of 81 months. The 5- and 10-year disease-free survival rates were 77.3% and 70.3%, respectively, and the 5- and 10-year local control rates were 88.2% and 80.2%, respectively. Patients undergoing ESBS demonstrated a significantly shorter operating time, period from operation to ambulation, hospitalization period, and less blood loss than those undergoing craniotomy combined with ESBS. Conclusion: Our treatment protocol was found to afford favorable outcomes. Patients who underwent endoscopic resection showed lower complication rates and better perioperative data than those who underwent craniotomy combined with ESBS. With appropriate case selection, ESBS is considered a useful approach for ONB. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Review of neoplasia in fish at a large display aquarium, 2005–2021.
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Wright, Sarah E., Pawlik, Michael, Snyman, Heindrich N., and Haulena, Martin
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MARINE fishes ,SALTWATER fishing ,AQUARIUMS ,BENIGN tumors ,AUTOPSY ,TUMORS - Abstract
Fish maintained in managed care may have longer lifespans as a result of advances in veterinary medicine and husbandry and reduced risk of predation. Neoplasia is of increasing interest in managed aquarium populations. However, few studies have systematically evaluated neoplasia in managed fish populations. Our objective in this retrospective study was to review and describe neoplasia diagnosed in fish at a large public display aquarium between 2005 and 2021. Any fish diagnosed with neoplasia on either antemortem or postmortem evaluation during the study period was included, and all medical records, biopsy, and autopsy reports were reviewed. Sixty-two fish met the inclusion criteria; 37 species were included in the study population, most of which were tropical freshwater fish (n = 34 fish). Thirty-two types of neoplasia were identified. Ten fish had benign neoplasms, and 53 fish had malignant neoplasms. The most common neoplasms were of epithelial and neuroectodermal origin. The most common site of tumor origin was the skin. Our data suggest that mesenchymal neoplasms may be more common in cold saltwater fish than in tropical freshwater and saltwater fish. Malignant neoplasms were most commonly diagnosed in the study population and should be a top differential when neoplasms are identified in fish managed under human care. Our study contributes to the overall knowledge of the health of aquarium fish and may aid clinicians in characterizing neoplasia that may be present in fish under human care. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors.
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Lui, Christopher G., Badash, Ido, Tang, Liyang, Mark, Michelle E., Batra, Pete S., and Wrobel, Bozena B.
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NEUROBLASTOMA , *PARANASAL sinuses , *PARANEOPLASTIC syndromes , *TUMORS , *CANCER relapse , *ARACHNOID cysts - Abstract
Objectives Ectopic olfactory neuroblastoma is an uncommon manifestation of an already rare neoplasm. We aimed to systematically review the literature for cases of ectopic olfactory neuroblastoma to better characterize this rare disease entity and to present two new case reports. Methods A search of the PubMed and Embase databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify English-language articles reporting cases of ectopic olfactory neuroblastoma, published from 1955 through November 2021. Results Sixty-six cases of ectopic olfactory neuroblastoma were identified in 62 articles including the current review. Ectopic olfactory neuroblastoma arose in a wide age range (2–89 years) without significant sex predilection. It occurred most commonly in the ethmoid (25%), maxillary (25%), and sphenoid (16%) sinuses. Seventy-three percent of cases presented with low Hyams grade (I and II). The most common symptoms were nasal obstruction (32%) and epistaxis (32%). Paraneoplastic syndromes were observed in 27% of patients. The most common treatment was surgical resection followed by adjuvant radiotherapy. Overall, 76% of all patients were disease-free at the time of last follow-up. Locoregional recurrences and distant metastases were found in 19 and 5% of cases, respectively. Conclusion This systematic review describes previously reported cases of ectopic olfactory neuroblastoma, a disease entity with poorly understood characteristics. Physicians should consider olfactory neuroblastoma in the differential diagnosis for sinonasal masses, as their ectopic presentation may present considerable diagnostic and therapeutic difficulties. Patients with olfactory neuroblastoma may benefit from long-term follow-up and routine endoscopic examinations for surveillance of ectopic recurrences. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Radiologic overview of sinonasal lesions
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Mohammed U. Syed, Steve J. Stephen, and Akm A. Rahman
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sinonasal malignancy ,adenocarcinoma ,esthesioneuroblastoma ,rhabdomyosarcoma ,sinonasal undifferentiated carcinoma ,squamous cell carcinoma ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Sinonasal tumors are often malignant and comprise approximately 3% of all head and neck malignancies. Half of these tumors arise in the nasal cavity, and other common locations of origin include the ethmoid and maxillary sinuses. Some unique clinical features are anosmia and altered phonation but the most common general features include headache, epistaxis, and diplopia. CT and MRI may be used to assess tumor location, invasion of adjacent tissue, presence of metastasis, internal tumor heterogeneity, and contrast enhancement. Local invasion of the tumor beyond the sinonasal tract can impact adjacent structures such as the cranial nerves, skull base, branches of the internal carotid artery, and orbit leading to neurologic signs, facial pain, and diplopia. Imaging is used in the diagnosis, staging, and treatment planning of sinonasal tumors. This collection of benign and malignant sinonasal tumors will include some rare and unique cases with an emphasis on imaging features demonstrating a wide variety of pathologies.
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- 2024
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19. Olfactory neuroblastoma with orbital protrusion arising in the background of maxillary carcinoma.
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Wadhwani, Nikhar and Bhola, Nitin
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NASAL tumors , *CRIBRIFORM plate , *SQUAMOUS cell carcinoma , *NASAL cavity , *NEUROECTODERMAL tumors , *NEUROBLASTOMA - Abstract
An uncommon entity in the class of malignant neuroectodermal nasal tumors is the olfactory neuroblastoma, which originates in the roof of the nasal cavity from the olfactory epithelium. It is often mistaken by clinicians for a nasal polyp because it presents with indistinct features such as nasal obstruction and secondary sinus disease. Olfactory neuroblastoma has been observed to cause morbidity by distant metastasis, invasion through the cribriform plate, and secondary meningitis in most instances. It exhibits a range of biologic activities, from slow growth accompanied by long-term patient survival to a very aggressive malignancy with extensive metastases. We report the incidence of a rare case in which a patient, previously operated on and irradiated for squamous cell carcinoma of the maxilla, developed an olfactory neuroblastoma with orbital protrusion. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy
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National Institutes of Health (NIH), National Cancer Institute (NCI), and Annie W. Chan, MD, Assistant Professor
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- 2023
21. Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation.
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Dharmarajan, Harish, Choby, Garret, Abi Hachem, Ralph, Kuan, Edward C., Levine, Corinna G., Sanusi, Olabisi, Schuman, Theodore, Tang, Dennis, Yim, Michael, and Geltzeiler, Mathew
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Historically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a patient's quality of life without definitive added benefit in survival. The prevalence of occult intracranial disease is low, especially for Hyams grade I and II tumors. A unilateral approach sparing the contralateral cribriform plate and olfactory system can be considered for select cases of early stage, low‐grade tumors when the disease does not cross midline to involve the contralateral olfactory cleft or septal mucosa and when midline dural margins can be cleared with frozen pathology. Approximately half of patients who undergo unilateral resection may have residual olfaction even with adjuvant unilateral radiation. Early data suggest favorable disease‐free survival and overall survival for patients who underwent the unilateral approach; however, larger sample studies are needed to confirm comparability to bilateral resections regarding oncologic outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Characterizing Immune Infiltration in Esthesioneuroblastoma Subtypes Through Gene Expression Deconvolution.
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Batchu, Sai, Gill, Amarbir S., and Karsy, Michael
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TUMOR-infiltrating immune cells , *GENE expression , *IMMUNOLOGIC memory , *MACHINE learning , *B cells , *SMELL disorders - Abstract
Esthesioneuroblastoma (ENB) is a rare cancer deriving from the olfactory mucosa. Among the basal or neural genomic subtypes, the basal subtype is associated with poorer survival, poor differentiation, and higher levels of tumor-infiltrating immune cells (TIICs). The immune microenvironment of these ENB subtypes remains unclear. We used an established machine learning algorithm on ENB transcriptomic profiles. The authors characterized 22 immune cell populations using the CIBERSORTx deconvolutional machine learning pipeline on RNA sequencing data from 18 ENB cases. The characterization aimed to elucidate differences in relative proportions and populations of TIICs between basal and neural ENB. No differences in age, Hyams, Dulguerov, IDH2 mutation, or PD-L1 expression were seen between basal and neural subtypes of ENB (P > 0.05). Also, no difference in median overall survival was appreciated (52.0 ± 13.1 months vs. 50.0 ± 43.2 months, P = 0.5). As a cohort, M2 macrophages were the most abundant subpopulation (14%) followed by naïve B cells (13%) and CD4 memory resting T cells (12%). No gross differences in CD20, CD4, or CD8 cells/mm2 were apparent on gross histology (P > 0.05). However, further analysis showed that activated CD4 memory T cells were significantly increased in the basal ENBs, whereas resting dendritic cells were increased in the neural ENB subtype. The TIIC profiles alone could not differentiate between basal and neural ENB, but did suggest immunoprofile differences. Basal and neural subtypes display distinct TIIC involvement, which may impact their difference in outcome. These findings provide the framework for further investigation in novel immunomodulation strategies for ENB. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Esthesioneuroblastoma: 38 years of experience in an oncological center.
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Costa, Susana P. F., Rocha, Eduardo, Rodrigues, Jéssica, Soares, André, Moreira, Diana, and Vieira, Cláudia
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Background: Esthesioneuroblastoma (ENB) is an uncommon malignant sinonasal tumor. There are few data regarding ENB management, namely its treatment. We review our institute's experience in the treatment of ENB and evaluate survival outcomes. Materials and methods: Retrospective study of patients with ENB treated between 1984-2022. A total of 20 patients were identified, 13 men and 7 women, aged between 20 and 76 years. Results: Eleven patients were stage C of the modified Kadish staging system at initial presentation, 7 stage B, 1 stage A and 1 stage D. Seventeen patients underwent surgery alone or combined with adjuvant treatment (radiotherapy or chemoradiotherapy). The majority of the patients (71.4%) treated with surgery alone were stage B, whereas most of the patients (63.6%) that underwent surgery combined with adjuvant treatment were stage C. Five of the 7 patients treated with surgery alone had a locoregional recurrence. Two of the 10 patients treated with surgery followed by adjuvant treatment had relapsed, locoregionally and at a distance, respectively. One patient was treated with chemotherapy and 2 patients were treated with chemoradiotherapy and neoadjuvant chemotherapy followed by chemoradiotherapy, respectively. The recurrence and persistence rates were 35% and 15%, respectively. The median time from the end of the first treatment to recurrence was 20.9 months. Two- and 5-year overall survival rates were 83.9% and 77.9%; while progression-free survival rates were 76.7% and 61.0%, respectively. Conclusions: Sixty percent of patients were treated with a multimodal approach, which appeared to be a favorable strategy for the majority of patients. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Upright proton therapy for esthesioneuroblastoma: a single-institution experience.
- Author
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Gordon, Konstantin, Gulidov, Igor, Smyk, Daniil, Semenov, Alexey, Golubev, Kirill, Lemaeva, Alyona, Koryakin, Sergey, Jumaniyazova, Enar, Vishnyakova, Polina, Eremina, Irina, Fatkhudinov, Timur, and Kaprin, Andrey
- Subjects
PROTON therapy ,CORONAVIRUS diseases ,PROGRESSION-free survival ,TUMOR treatment ,CANCER invasiveness ,OVERALL survival - Abstract
Aim: This study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position. Background: Esthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximity to vital structures. Proton therapy (PT) is often considered the optimal radiation treatment for head-and-neck tumors, although of limited availability. Upright PT delivered using fixed pencil beamline and rotating chair is a fairly promising option. Methods: This is a single-center experience describing the outcomes of PT in 14 patients with ENB treated between January 2016 and October 2022; half of the cases had a history of previous irradiation. The therapy was applied using a fixed pencil beamline with 6D-chair for positioning. The median dose was 63 GyRBE (total range 48-70 GyRBE; based on 1.1 RBE multiplier for protons) with 2.0 GyRBE per fraction. The mean gross tumor volume was 109.5 cm3 (17.1-257.7 cm3). Patient demography, pathology, treatment parameters and toxicity data were analyzed. Radiation-induced reactions were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v 4.0. Results: The median follow-up time was 28 months. The 1- and 2-year locoregional control rates constituted 100% and 88.9%, respectively; the median duration of local control was 52 months. The 1- and 2-year progression-free survival (PFS) rates constituted 92.9% and 75.0%, respectively; the median PFS duration was 52 months. The 1- and 2-year overall survival (OS) rates constituted 92.9% and 84.4%, respectively. Two patients died of noncancer-related causes (coronavirus-induced pneumonia) and 1 patient died of tumor progression. All patients tolerated PT well without any treatment gaps. Serious late toxicity reactions included glaucoma in 1 patient and cataract in 2 patients, in over half a year since irradiation. Conclusion: PT with upright design of the unit affords promising outcomes in terms of disease control and toxicity rates in ENB, a sinonasal tumor of complicated localization. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Critical Appraisal of Surgical Modalities in Olfactory Neuroblastoma: A Systematic Review.
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Arrieta, Mariana Agudelo, Ocampo, Maria Isabel, Chacon, Sergio, Taub-Krivoy, Alex, Lacouture, Isabella, and Feo-Lee, Oscar
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NEUROBLASTOMA , *NASAL tumors , *SURVIVAL rate , *PROGRESSION-free survival , *NASAL cavity - Abstract
This article, published in the Journal of Neurological Surgery, provides a critical appraisal of surgical modalities in the treatment of olfactory neuroblastoma (ONB), a rare malignant tumor of the nasal cavity. The study conducted a systematic review of studies comparing endoscopic and open surgical interventions for ONB. The analysis included 57 studies and a total of 2046 patients who underwent surgical treatment for ONB. The findings indicate that the endoscopic approach had higher overall survival rates, disease-free survival rates, and lower mortality compared to the open approach. The study suggests that these differences may be related to the higher Kadish stages in the open approach group. The review aims to inform clinical decision-making and guide future research efforts in optimizing treatment strategies for ONB. [Extracted from the article]
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- 2024
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26. International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
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Kuan, Edward C., Wang, Eric W., Adappa, Nithin D., Beswick, Daniel M., London, Nyall R., Su, Shirley Y., Wang, Marilene B., Abuzeid, Waleed M., Alexiev, Borislav, Alt, Jeremiah A., Antognoni, Paolo, Alonso‐Basanta, Michelle, Batra, Pete S., Bhayani, Mihir, Bell, Diana, Bernal‐Sprekelsen, Manuel, Betz, Christian S., Blay, Jean‐Yves, Bleier, Benjamin S., and Bonilla‐Velez, Juliana
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PARANASAL sinuses , *NOSE , *BENIGN tumors , *LITERATURE reviews , *ALLERGIES - Abstract
Background: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field. Methods: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on the level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication. Results: The ICSNT document consists of four major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention. Conclusion: As an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Simple and safe resection of the crista galli.
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Omura, Kazuhiro, Nomura, Kazuhiro, Aoki, Satoshi, Takeda, Teppei, Ebihara, Teru, Kimple, Adam J., Thorp, Brian D., Zeatoun, Abdullah L., Otori, Nobuyoshi, and Senior, Brent A.
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DACRYOCYSTORHINOSTOMY ,SKULL base ,CECUM - Abstract
A critical procedure in the transcribriform approach is the resection of the crista galli. However, the standard technique for crista galli resection has several disadvantages. We reviewed the cases of patients with olfactory neuroblastomas who underwent an endoscopic endonasal transcribriform approach using a newly developed technique for crista galli resection. We performed a cadaveric study to measure the superior accessibility limits using the proposed method. We included 38 patients with olfactory neuroblastomas in this study. The tumor invaded the posterior crista galli in four patients. The anterior end of the crista galli was not invaded by the tumor. Our cadaveric study showed that the dura was approachable to the point that was 7.4 ± 1.3 mm superior and 23.2 ± 7.2 mm lateral to the foramen cecum following crista galli removal. By resecting the crista galli in advance, manipulation of the superior dura became feasible. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Olfactory neuroblastoma in children and adolescents: The EXPeRT recommendations for diagnosis and management
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Daniela Di Carlo, Giulia Fichera, Benoit Dumont, Enrico Pozzo, Beate Timmermann, Romain Luscan, Antoine Moya-Plana, Anna Synakiewicz, Ewa Bien, Nino Jorge dos Reis Farinha, Malgorzata Krawczyk, Rita Alaggio, Apostolos Pourtsidis, Brice Fresneau, Yves Reguerre, Tal Ben-Ami, Calogero Virgone, Jelena Roganovic, Jan Godzinski, Ines B Brecht, Dominik Schneider, Andrea Ferrari, Barbara Hero, Daniel Orbach, and Gianni Bisogno
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Esthesioneuroblastoma ,Olfactory neuroblastoma ,Nasal cavity ,Nasal neoplasms ,Rare disease ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Olfactory neuroblastoma (ON) is a rare tumor commonly presenting between 50 and 60 years of age. In pediatric age this tumor is even rarer, with an estimated incidence of 0.1 per 100,000 children up to 15 years. It arises from the olfactory neurorepithelium of the nasal cavity, and it can be locally aggressive, spreading to the orbital cavity, skull base, intracranial cavity. In rarer cases it can also give distant metastasis, more frequently to regional lymph nodes and less commonly to distant sites like liver, lungs and bones. Prognosis varies depending on the stage at presentation (including dural invasion, regional nodal involvement, and distant metastasis), the histological grade, and aspects related to the treatment, such as the possibility to achieve clear margins with surgery and the multimodal approach. Chemotherapy, surgery and radiotherapy have been used to treat these patients and the different approaches have been reported in the literature. Given the rarity of the disease no shared guidelines exist for the management of this entity in children, but some suggestions can be given to optimize the ON management.This study presents the internationally recognized recommendations for the diagnosis and treatment of ON in children and adolescents, established by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) group within the EU-funded project Pediatric Rare Tumors Network - European Registry (PARTNER).
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- 2024
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29. Olfactory neuroblastoma: diagnosis, management, and current treatment options.
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Tosoni, Alicia, Di Nunno, Vincenzo, Gatto, Lidia, Corradi, Giacomo, Bartolini, Stefania, Ranieri, Lucia, and Franceschi, Enrico
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COMBINED modality therapy ,DIAGNOSIS ,OPERATIVE surgery ,THERAPEUTICS ,SMELL disorders ,PARANASAL sinuses ,NEUROBLASTOMA - Abstract
Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application. Although there is agreement that multimodal therapy is needed, the optimal use of chemotherapy is still unknown. The rarity of the disease, makes difficult to draw definitive conclusions about the role of systemic treatment in induction and concomitant setting. [ABSTRACT FROM AUTHOR]
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- 2023
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30. Treatment outcomes and prognostic factors of esthesioneuroblastoma -- a retrospective study from South India.
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Nair, Lekha Madhavan, Mathew, John Mohan, Rafi, Malu, Thommachan, Kainickal Cessal, K. M., Jagathnath Krishna, Varghese, Bipin T., and Ravikumar, Rejnish
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PROGNOSIS , *TREATMENT effectiveness , *NEURAL crest , *OVERALL survival , *REGRESSION analysis , *SMELL disorders - Abstract
Esthesioneuroblastoma (ENB) or olfactory neuroblastoma is a rare malignant neoplasm arising from the neural crest cells of the olfactory epithelium. The optimum treatment for this rare disease is still unclear. Most of the available literature on this rare head and neck tumour is limited to small retrospective series and single institutional reports. We conducted a retrospective study to investigate the clinical profile, treatment outcomes and prognostic factors of patients with ENB treated at a tertiary cancer centre in south India. Patients with a histopathological diagnosis of ENB treated from 2000 to 2019 were included. Patient demographics, tumour characteristics, stage, treatment details and outcome data were identified from medical records. Overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method and the log-rank test was used for comparison. The prognostic factors were identified using Cox regression analysis. Forty-two patients underwent treatment for ENB from 2000 to 2019. Twenty-six patients underwent surgery. Twelve patients received radical radiotherapy (RT) while 24 patients underwent adjuvant radiation. After a median follow-up of 71 months, the estimated OS and DFS at 4 years were 64.4% and 54%, respectively. The estimated 4-year OS for modified Kadish A, B, C and D stages was 75.0%, 90.9%, 56.4% and 0%, respectively. Modified Kadish stage, nodal involvement, orbital invasion, intracranial extension, surgery, RT treatment and use of chemotherapy were significant predictors of OS and DFS in univariate Cox regression analysis. Orbital invasion and RT treatment were significant predictors of DFS in the multivariate analysis as well. However, only RT treatment came out to be a significant predictor for OS in multivariate Cox regression analysis. Surgery is the mainstay of treatment. Adjuvant RT may improve local control and survival in advanced cases. Advanced modified Kadish stage, lymph node involvement and orbital invasion are associated with poor outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Rare case of mortality after hemorrhagic property of esthesioneuroblastoma.
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Furr, Todd, Grodman, Brandon, and Heffernan, Jeremy
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CRIBRIFORM plate , *NASAL cavity , *GLASGOW Coma Scale , *OPERATIVE surgery , *SMELL disorders ,TUMOR surgery - Abstract
Esthesioneuroblastoma is a tumor arising from olfactory neuroepithelium with an incidence of four per million. This case presents a rare nasal cavity neoplasm with hemorrhagic properties that may lead to significant sequelae. We present a 69-year-old male patient who presented with worsening altered mental status over the past 6-7 months. His Glasgow coma scale was a nine, showing a large mass centered at the cribriform plate with extension intracranially, sinonasal cavity, and bilateral orbits on diagnostics. Bifrontal craniotomy was performed one day after admission with resection of the tumor in the cranial fossa and intranasally, and decompression of the brainstem, frontal lobes, and third ventricle. After surgery, the patient was managed in the intensive care unit but continued to deteriorate. He was confirmed to have no meaningful brain activity and eventually deceased seven days after admission. Depending on the tumor stage, esthesioneuroblastoma can have a favorable prognosis with proper therapies. Different surgical techniques for ENB lead to the question of which therapeutic modality is the best because of the tumor’s gross hemorrhagic properties. With adjunctive radiation therapy and/or chemotherapy, more research can bring light to proper surgical techniques. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Radiographic predictors of occult intracranial involvement in olfactory neuroblastoma patients.
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Geltzeiler, Mathew, Choby, Garret W., Ji, Keven Seung Yong, JessMace, C., Almeida, Joao Paulo, de Almeida, John, Champagne, Pierre‐Olivier, Chan, Erik, Ciporen, Jeremy N., Chaskes, Mark B., Cornell, Sarah, Drozdowski, Veronica, Fernandez‐Miranda, Juan, Gardner, Paul A., Hwang, Peter H., Kalyvas, Aristotelis, Kong, Keonho A., McMillan, Ryan A., Nayak, Jayakar V., and Patel, Chirag
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SKULL base , *OLFACTORY bulb , *CRIBRIFORM plate , *MAGNETIC resonance imaging , *OCCULTISM , *SMELL disorders , *NEUROBLASTOMA - Abstract
Background: Traditional management of olfactory neuroblastoma (ONB) includes margin‐negative resection with removal of cribriform plate, dura, and olfactory bulb, regardless of intracranial disease. This approach may be overtreating certain patients. Our investigation examines risk factors associated with occult intracranial disease to optimize therapeutic outcomes. Methods: This retrospective, multi‐institutional cohort study examined clinical covariates associated with occult intracranial involvement. Patient demographics, staging, Hyam's grade, and pathologic involvement of dura, olfactory bulb/tract, and brain were collected. Diagnostic imaging was reviewed. Positive and negative predictive value (NPV) were estimated along with effect size estimates. Cox hazard regression examined associations with overall survival (OS) and disease‐free survival (DFS). Results: A total of 224 subjects with new diagnoses of ONB (2005–2021) were identified. Skull base bone involvement on computed tomography (CT) had the highest NPV for pathologic dura (88.0%), olfactory bulb (88%), and brain involvement (97.3%). Hyam's grade category was significantly associated with dural involvement (φC = 0.26; 95% confidence interval [CI]: 0.16, 0.42). Subjects without radiologic skull base involvement (n = 66) had pathologic positivity of 12.1%. Within this subgroup, Hyam's grade was clinically significant for dural positivity (φ = 0.34; 95% CI: −0.12, 0.71) with 28.6% involvement in high grade tumors. Neither clinical nor pathologic positivity of intracranial structures were associated with significantly different OS or DFS. Conclusions: Both CT and magnetic resonance imaging (MRI) had reasonably good NPV for involvement of dura and olfactory bulb. Higher Hyam's grade was associated with dural involvement. Patients with low‐grade tumors not involving the skull base may be suitable for avoiding skull base resection; however, further investigation is warranted. [ABSTRACT FROM AUTHOR]
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- 2023
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33. Upright proton therapy for esthesioneuroblastoma: a single-institution experience
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Konstantin Gordon, Igor Gulidov, Daniil Smyk, Alexey Semenov, Kirill Golubev, Alyona Lemaeva, Sergey Koryakin, Enar Jumaniyazova, Polina Vishnyakova, Irina Eremina, Timur Fatkhudinov, and Andrey Kaprin
- Subjects
esthesioneuroblastoma ,proton therapy ,radiation therapy ,reirradiation ,brain invasion ,upright position ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
AimThis study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position.BackgroundEsthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximity to vital structures. Proton therapy (PT) is often considered the optimal radiation treatment for head-and-neck tumors, although of limited availability. Upright PT delivered using fixed pencil beamline and rotating chair is a fairly promising option.MethodsThis is a single-center experience describing the outcomes of PT in 14 patients with ENB treated between January 2016 and October 2022; half of the cases had a history of previous irradiation. The therapy was applied using a fixed pencil beamline with 6D-chair for positioning. The median dose was 63 GyRBE (total range 48–70 GyRBE; based on 1.1 RBE multiplier for protons) with 2.0 GyRBE per fraction. The mean gross tumor volume was 109.5 cm3 (17.1–257.7 cm3). Patient demography, pathology, treatment parameters and toxicity data were analyzed. Radiation-induced reactions were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v 4.0.ResultsThe median follow-up time was 28 months. The 1- and 2-year locoregional control rates constituted 100% and 88.9%, respectively; the median duration of local control was 52 months. The 1- and 2-year progression-free survival (PFS) rates constituted 92.9% and 75.0%, respectively; the median PFS duration was 52 months. The 1- and 2-year overall survival (OS) rates constituted 92.9% and 84.4%, respectively. Two patients died of non-cancer-related causes (coronavirus-induced pneumonia) and 1 patient died of tumor progression. All patients tolerated PT well without any treatment gaps. Serious late toxicity reactions included glaucoma in 1 patient and cataract in 2 patients, in over half a year since irradiation.ConclusionPT with upright design of the unit affords promising outcomes in terms of disease control and toxicity rates in ENB, a sinonasal tumor of complicated localization.
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- 2024
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34. Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation
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Dumont, Rebecca A, Diaz, Miguel Fernando Palma, Hsu, William, and Sepahdari, Ali R
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Biomedical Imaging ,Brain Disorders ,Cancer ,Rare Diseases ,Neurosciences ,Neuroblastoma ,Neurological ,olfactory neuroblastoma ,esthesioneuroblastoma ,MRI ,radiology-pathology correlation ,radiology–pathology correlation ,Clinical sciences - Abstract
The purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging and pathology data. Eighteen of thirty-one patients (58.1%) had evidence of intracranial extension on MRI, while four (22.0%) demonstrated cyst formation at the brain-tumor interface. The extent of intracranial extension was by far the strongest predictor for intracranial cyst formation, regardless of Hyams tumor grade, using a binary logistics regression model (p = 0.002) and ROC curve analysis (AUC 94.6%). Cyst formation at the brain-tumor interface was an uncommon imaging finding, and tends to occur with a larger component of intracranial tumor extension.
- Published
- 2022
35. Miscellaneous Skull Base Tumors
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Das, Joe M and Das, Joe M
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- 2023
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36. Dermatomal Pain
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Abdelaziz, Osama S., De Salles, Antonio A. F., Abdelaziz, Osama S., and De Salles, Antonio A.F.
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- 2023
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37. Olfactory Neuroblastoma Is Not Always Located at the Roof of the Nasal Cavity
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Pornrujee Hirunpat, Theeraphol Panyaping, and Siriporn Hirunpat
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olfactory neuroblastoma ,computed tomography ,magnetic resonance imaging ,nasal cavity ,sinuses ,esthesioneuroblastoma ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Objectives: To evaluate the imaging characteristics of the tumor, emphasizing its location, and to determine the frequency of typical and atypical locations of olfactory neuroblastoma (ONB). Materials and Methods: We retrospectively reviewed the computed tomography and magnetic resonance imaging findings of patients with pathologically proven ONB between April 2000 and April 2023. Demographic information, chief complaints, tumor location, and tumor extension were extracted. Results: Of the 58 patients, 50 (86.2%) had the epicenter of the mass at the superior part of the nasal cavity, while eight patients (13.8%) had the epicenter at other atypical locations: seven patients (12.1%) at the middle part of the nasal cavity and one patient (1.7%) within both sphenoid sinuses. Conclusion: ONB is not always present in the upper part or the roof of the nasal cavity, and a significant number of ONBs are occasionally found in the rest of the nasal cavity and other atypical locations.
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- 2024
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38. Short-Term Morbidity and Predictors of Adverse Events Following Esthesioneuroblastoma Surgery
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Goshtasbi, Khodayar, Birkenbeuel, Jack L, Abouzari, Mehdi, Lehrich, Brandon M, Yasaka, Tyler M, Abiri, Arash, Muhonen, Ethan G, Hsu, Frank PK, and Kuan, Edward C
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Patient Safety ,Evaluation of treatments and therapeutic interventions ,6.4 Surgery ,Esthesioneuroblastoma ,Olfactory ,Humans ,Length of Stay ,Morbidity ,Nasal Cavity ,Nose Neoplasms ,Postoperative Complications ,Reoperation ,Retrospective Studies ,Risk Factors ,esthesioneuroblastoma ,olfactory neuroblastoma ,National Surgical Quality Improvement Program ,morbidity and mortality ,Otorhinolaryngology ,Clinical sciences ,Dentistry - Abstract
IntroductionThe short-term adverse events and predictors of morbidity in surgical resection of esthesioneuroblastoma (ENB) are largely unknown, and investigating these variables can help direct planning for at-risk patients.MethodsThe 2005-2017 National Surgical Quality Improvement Program database was queried to identify patients with a diagnosis of ENB undergoing skull base surgery for tumor resection. Information regarding demographics, patient morbidity score, pre-operative and intra-operative data, and post-operative outcomes were extracted. Cox proportional hazard analysis was utilized to assess complication and readmission/reoperation rates.ResultsA total of 95 patients undergoing skull base surgery for resection of ENB were included. Mean age, BMI, operation time, and post-operative length of stay (LOS) of the cohort were 53.6 ± 16.2 years, 29.1 ± 6.5, 392.0 ± 204.6 minutes, and 5.8 ± 4.6 days, respectively. In total, 31 patients (32.6%) experienced at least one 30-day adverse event, which included blood transfusion intra-operatively or within 72 hours from the operation (22.1%), readmission (10.7%), intubation >48 hours (7.4%), reintubation (4.2%), organ or space infection (4.2%), reoperation (4.0%), superficial or deep surgical site infection (2.1%), sepsis (2.1%), pulmonary embolism (1.1%), and myocardial infarction (1.1%). Patients who experienced at least one adverse event had significantly higher operation time (486.8 ± 230.4 vs. 347.5 ± 176.2 minutes, p = 0.002), LOS (9.2 ± 5.6 days vs. 4.2 ± 3.0, p
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- 2021
39. Small Round Blue Cell Tumours of the Sinonasal Area: Our 5 year Experience in a Tertiary Care Centre in India.
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Reddy Y, Mounika, Padmanabhan, Sourabh, Babu A, Shobhan, Swarna B, Sai, and Nagaraju
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PARANASAL sinuses , *CELL tumors , *NEUROENDOCRINE tumors , *TERTIARY care , *TUMORS , *SYNOVIOMA , *PITUITARY cancer - Abstract
Purpose: The main purpose of this study is to understand the characteristics and management of sinonasal small round blue cell tumors and also to emphasise the role of immunohistochemistry in their diagnosis and on the outcomes after endoscopic/open excision in these patients. Methods: This is a retrospective study conducted at a tertiary care referral centre in India which included 38 patients with sino nasal for a period of 5 years. All the patients were evaluated clinically and radiologically. All cases were confirmed diagnostically with histopathological examination and immunohistochemistry following surgical excision either by endoscopic or open approach. Some of the cases underwent post operative radiotherapy. Results: In our study, among 176 cases diagnosed with Sino nasal malignancies, 38 (21.6%) cases were diagnosed with sinonasal small round blue cell tumors with male to female ratio 1.4:1. Most common histopathological type among all the sinonasal small round blue cell tumors that presented to us was esthesioneuroblastoma i.e., 8 (21%) patients followed by pituitary macroadenoma in 7(8.4%) patients. Other types are undifferentiated squamous cell carcinoma 10(13.1%), craniopharyngioma 8(10.5%), lymphoma 3(7.9%), synovial/spindle cell sarcoma, malignant melanoma and adenocarcinoma 1(2.6%) each. Schwannoma, rhabdomyosarcoma, neuroendocrine carcinoma and neurofibroma 2 (5.2%) each. Conclusion: Sinonasal small round blue cell tumors are extremely rare tumours. Histopathological diagnosis with immunohistochemistry is characteristic of various tumors and is conclusive for diagnosis. Knowledge of these tumor entity is essential as early diagnosis helps in further management in preventing spread to vital structures and improving outcome. Most of the tumors have a multimodality treatment approach which includes surgical excision, radiotherapy and chemotherapy. [ABSTRACT FROM AUTHOR]
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- 2023
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40. A rare presentation of esthesioneuroblastoma: a case report and review of the literature.
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Sghier, Ahmed Ben, Samba, Soumiya, Bouabid, Meriem, Berhili, Soufiane, Moukhlissi, Mohammed, and Mezouar, Loubna
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LITERATURE reviews , *SURGICAL excision , *NASAL cavity , *RADIOTHERAPY , *PREVENTIVE medicine , *SMELL disorders - Abstract
Esthesioneuroblastoma is a rare malignant tumor developing from the olfactory neuroepithelium. It represents less than 5% of all cancers of the nasal cavity. We are going to report the observation of a patient followed at the regional oncology center of Oujda in Morocco who presented a locally advanced esthesioneuroblastoma. Treatment consisted of surgical resection followed by adjuvant radiotherapy on the tumor bed. Currently, the patient is in good control of his disease. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Long-term survival outcomes and recurrence patterns of olfactory neuroblastoma: A 13-year experience at a single institution.
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Kikuchi, Masahiro, Nakagawa, Takayuki, Kitada, Yuji, Matsunaga, Mami, Tanji, Masahiro, Hiraoka, Shinya, Nakashima, Ryota, Nakajima, Aya, Yoshimura, Michio, and Omori, Koichi
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NEUROBLASTOMA , *SURVIVAL rate , *NECK dissection , *HEAD & neck cancer , *RADIOTHERAPY , *LYMPHATIC metastasis , *SKULL base , *BONE metastasis , *ENDOSCOPIC surgery - Abstract
Objectives: Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant neoplasm of the nasal vault and anterior skull base. The results of treatment for ONB are relatively good; however, regional and distant metastases can develop several years after definitive treatment. This study aimed to validate the treatment modality of ONB for oncological outcomes, especially for regional recurrence. Methods: We retrospectively reviewed the medical records of 22 patients diagnosed with ONB at Kyoto University Hospital between 2009 and 2020. Descriptive statistics were calculated, and Kaplan–Meier curves were used. Results: The median follow-up time was 58.2 months. One (4.5%) patient was clinically node positive, (cN+) and the remaining 21 (95.5%) were clinically node negative (cN0) at presentation. Eighteen patients underwent an endoscopic endonasal approach (EEA) for primary resection, and the remaining four patients underwent a combined EEA and transcranial approach. Elective neck dissection was not performed for 21 patients with cN0 ONB, whereas unilateral neck dissection with removal of ipsilateral lateral retropharyngeal node was performed for one patient with cN+ ONB. Postoperative radiotherapy without concurrent chemotherapy was performed only at the primary tumor bed for 21 patients with cN0 ONB, and at the primary tumor bed and bilateral neck for one patient with cN+ ONB. The 5-year overall, disease-specific, and disease-free survival rates were 94.1%, 100%, and 69.6%, respectively. No patients developed local recurrence, but 6 (27.2%) patients experienced recurrence with a median time to recurrence of 36.4 months, including four and two patients who initially developed regional recurrences and bone metastases, respectively. Five (22.7%) patients had delayed neck recurrence. The salvage rate was only 60.0% in the five patients who had delayed neck recurrence. Regarding the level of delayed neck recurrence, 4 (18.2%) patients had lateral retropharyngeal lymph node metastases. Conclusion: Patients with ONB have excellent survival outcomes after endoscopic surgical resection of the primary lesion with postoperative radiotherapy only to the primary tumor bed. Despite excellent survival, delayed neck recurrence, including the lateral retropharyngeal lymph node, remains high. Because salvage surgery for lateral retropharyngeal lymph node recurrence is sometimes technically difficult, it may be better to extend the field of postoperative radiotherapy from the primary tumor bed only to include bilateral lateral retropharyngeal lymph node regions in patients with clinically N0 ONB. Further prospective studies with a large number of patients are needed to determine the extent of postoperative radiotherapy. [ABSTRACT FROM AUTHOR]
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- 2023
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42. Comparing the role of different treatment modalities in locoregionally advanced olfactory neuroblastoma: The 20‐year clinical experience of a single institution.
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Chai, Yue, Wei, Yuce, Zhang, Di, Qi, Fei, and Dong, Mei
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CANCER chemotherapy ,NEUROBLASTOMA ,NEOADJUVANT chemotherapy ,ADJUVANT chemotherapy ,OVERALL survival - Abstract
Background: The clinical value of different treatment modalities, especially systemic chemotherapy (CT) in patients with locoregionally advanced olfactory neuroblastoma (LA ONB) remains unclear. Methods: Patients with LA ONB from 2000 to 2020 at our center were collected retrospectively. The entire cohort was divided into combined systemic and local therapy (CSLT) versus local therapy (LT) groups (grouping method 1), and the same cohort was divided into neoadjuvant chemotherapy (NAC) versus non‐NAC groups (grouping method 2). CSLT group included patients treated with CT + LT. LT group included patients treated with surgery (SG), radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or any combination of the above methods. LT group was further divided into mono‐modality local therapy (MOLT) group and multi‐modality local therapy (MULT) group. MOLT group included patients treated with RT alone or SG alone. MULT group included patients treated with SG + RT/CCRT, or CCRT alone. NAC group included patients treated with NAC + LT ± adjuvant chemotherapy (ADC). Non‐NAC group included patients who received LT ± ADC. Results: A total of 111 patients with LA ONB were included. The median follow‐up was 80.2 months (range, 2.1–254.9). The 5‐ and 10‐year OS rates were 70.2% and 61.3%, respectively. In univariate analysis, patients treated with NAC (n = 43) had significantly better overall survival (OS) compared with those without NAC (n = 68) (p = 0.041). Patients in MULT group (n = 45) had significantly improved OS (p = 0.004) and PFS (p = 0.003) compared with those in MOLT group (n = 15). Multivariate analysis identified NAC and CSLT (n = 51) were independent prognostic factors for superior OS (p = 0.020, p = 0.046). Conclusions: Our study suggested that CSLT, especially a combination of NAC and LT, improved the survival of patients with LA ONB. Multiple treatment modalities yielded better PFS and OS compared to single‐modality treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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43. Olfactory neuroblastoma: diagnosis, management, and current treatment options
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Alicia Tosoni, Vincenzo Di Nunno, Lidia Gatto, Giacomo Corradi, Stefania Bartolini, Lucia Ranieri, and Enrico Franceschi
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esthesioneuroblastoma ,olfactory neuroblastoma ,chemotherapy ,radiotherapy ,surgery ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application. Although there is agreement that multimodal therapy is needed, the optimal use of chemotherapy is still unknown. The rarity of the disease, makes difficult to draw definitive conclusions about the role of systemic treatment in induction and concomitant setting.
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- 2023
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44. Primary Sellar Neuroblastoma Masquerading as a Pituitary Macroadenoma.
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Seshan, Nandini, Hanft, Simon, Goswami, Gayotri, and Syal, Arjun
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INAPPROPRIATE ADH syndrome , *INTERNAL carotid artery , *NEUROBLASTOMA , *CAVERNOUS sinus , *MAGNETIC resonance imaging , *NASAL cavity - Abstract
Olfactory neuroblastomas, or esthesioneuroblastomas, are rare and aggressive malignant tumors that typically arise from the olfactory neuroepithelium in the upper nasal cavity. In rare instances, they can be ectopic originating from areas outside the upper nasal cavity such as the sellar region. These tumors, also known as primary sellar neuroblastomas, may be mistaken for pituitary macroadenomas. We present a rare case of a primary sellar neuroblastoma in a 30-year-old woman with a prior diagnosis of presumed prolactinoma, status post transsphenoidal resection, with residual visual deficits, who presented with worsening vision and headaches. Pituitary magnetic resonance imaging showed a large sellar mass causing compression of the optic chiasm, and invasion of the right cavernous sinus and bilateral cavernous internal carotid arteries. The patient underwent a second transsphenoidal resection. Postoperatively, she developed central adrenal insufficiency, central hypothyroidism, central hypogonadism, and transient syndrome of inappropriate antidiuretic hormone secretion. Owing to rapid tumor regrowth, she underwent a craniotomy with plans for radiation treatment. This condition is challenging to diagnose and has poorly defined clinical management guidelines. An early, aggressive approach with surgical intervention is recommended. [ABSTRACT FROM AUTHOR]
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- 2023
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45. Presentación de un caso y revisión de literatura: anestesia total intravenosa en cirugía de estesioneuroblastoma.
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Gutiérrez-Pérez, Nancy, Miguel Tapia-Hernández, Héctor, Noemi Torres-Campos, Sandra, and Becerra-Escobedo, Guillermo
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Esthesioneuroblastoma is a neoplasm of the olfactory neuroepithelium cells, it has a low incidence of 0.4 per million inhabitants. It is characterized by symptoms such as sinusitis, epistaxis, headache, visual impairment, nasal obstruction, hyposmia, and rhinorrhea. We present the case of a 29-year-old male patient with Kadish C stage esthesioneuroblastoma, who was scheduled for surgical resection under total intravenous anesthesia with satisfactory results during the surgical procedure. [ABSTRACT FROM AUTHOR]
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- 2023
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46. Olfactory neuroblastoma: Up-to-date review and our experience.
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Rusu, Bianca, Lupoi, Daniel, Dragomir, Mihai, and Badea, Carmen
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NEUROBLASTOMA , *NASAL cavity , *NASAL mucosa , *NEUROECTODERMAL tumors , *TUMOR grading , *RHINORRHEA - Abstract
Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant neuroectodermal tumor originating primarily from the basal layer of the olfactory epithelium in the roof of the nasal cavity. The most common symptoms are nasal obstruction, anosmia, recurrent epistaxis, rhinorrhea and excessive lacrimation. Imaging studies are helpful for assessing the extent of olfactory neuroblastoma, as well as grading the tumor. The definitive diagnosis is based on histopathological exam and immunohistochemistry profile and it might be quite challenging because the tumor can mimic other sinonasal malignancies. Because of the small number of reported cases and the lack of prospective research, the optimal treatment for olfactory neuroblastoma is still controversial. However, it is generally believed that surgical resection followed by radiotherapy gives the best outcome in terms of recurrence and survival rates. Keeping in mind the rarity of olfactory neuroblastoma and the diagnostic difficulty, the aim of this study is to improve the understanding of the clinical features by reviewing the literature focusing on the recent advances in the diagnosis and treatment of ONB. Moreover, we are reporting an atypical case of an aggressive type of olfactory neuroblastoma treated through a multimodal approach, with no signs of tumor recurrence after a 3-month follow-up. [ABSTRACT FROM AUTHOR]
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- 2023
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47. Lymph node metastasis from olfactory neuroblastoma at presentation and as disease relapse: A systematic review and proportion meta‐analysis of prevalence data and variables influencing regional control.
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Tomasoni, Michele, Marazzi, Elisa, Rampinelli, Vittorio, Mattavelli, Davide, Schreiber, Alberto, Deganello, Alberto, and Piazza, Cesare
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LYMPHATIC metastasis ,SMELL disorders ,NEUROBLASTOMA ,DISEASE relapse ,SYMPTOMS ,SURVIVAL rate - Abstract
Background: Aim of this study is to investigate the prevalence of cervical nodal metastasis at presentation and as disease relapse in primary, treatment‐naive olfactory neuroblastoma (ONB), and to review treatment modalities, risk factors for regional failure and survival outcomes according to nodal status. Methods: A systematic review and proportion meta‐analysis were conducted following PRISMA guidelines based on PubMed, Web of Science, and Scopus. Results: Eighteen articles were examined. The pooled proportion of patients with nodal metastasis at presentation (11.5%) was comparable to that of cN0 patients not receiving elective neck treatment developing nodal metastasis during follow‐up (12.3%). Of the latter, most were Kadish stage C tumors (85.5%). Conclusions: Cervical involvement is common both at presentation and during follow‐up of cN0 ONB. The highest risk of developing late nodal metastasis is seen in cN0 patients with Kadish stage C tumors not receiving elective neck treatment. Elective cN0 neck treatment should be encouraged in selected patients to increase regional control. [ABSTRACT FROM AUTHOR]
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- 2023
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48. An exceptionally rare case of Cushing's syndrome caused by ectopic ACTH syndrome due to olfactory neuroblastoma in childhood.
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Özhan, Bayram, Yıldırım Çakar, Didem, Gülten, Gülsün, and Yalçın, Nagihan
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Ectopic adrenocorticotropic hormone secretion/syndrome (EAS) is caused by excess secretion of ACTH leading to hypercortisolism by non-pituitary, commonly malignant origins. We present a rare case of esthesioneuroblastoma (ENB) complicated by EAS in the follow-up period. A child presented with nasal obstruction at the age of 10 months. Polypoid mass obstructing the right nasal passage was detected. Magnetic resonance imaging (MRI) showed a lesion limited within the nasal cavity. The lesion was completely removed by nasal endoscopic surgery. The pathologic examination revealed a diagnosis of esthesioneuroblastoma. It was confined to the nasal cavity so chemotherapy/radiotherapy was not administered and began to follow up. At 28 months of age, he presented with rapid weight gain. Laboratory data were consistent with Cushing's syndrome (CS). High-dose dexamethasone suppression test and imaging studies led us to think of ectopic ACTH syndrome originated from ENB relapse. After partial resection of the tumor, ketoconazole treatment was started along with chemotherapy. Hypercortisolemia was kept under control with ketoconazole treatment as long as the treatment was maintained. Cushing syndrome is a rare endocrine disorder. Adrenal sources of hypercortisolism and ectopic sources of ACTH overproduction should be investigated especially in young children. [ABSTRACT FROM AUTHOR]
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- 2023
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49. Impact of esthesioneuroblastoma treatment delays on overall patient survival.
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Tsutsumi, Kotaro, Ahmed, Khwaja H., Goshtasbi, Khodayar, Torabi, Sina J., Mohyeldin, Ahmed, Hsu, Frank P.K., and Kuan, Edward C.
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Objectives: To characterize clinical factors associated with esthesioneuroblastoma treatment delays and determine the impact of these delays on overall survival. Study Design: Retrospective database analysis. Methods: The 2004–2016 National Cancer Database was queried for patients with esthesioneuroblastoma managed by primary surgery and adjuvant radiation. Durations of diagnosis‐to‐treatment initiation (DTI), diagnosis‐to‐treatment end (DTE), surgery‐to‐RT initiation (SRT), radiotherapy treatment (RTD), and total treatment package (TTP) were analyzed. The cohort was split into two groups for each delay interval using the median time as the threshold. Results: A total of 814 patients (39.6% female, 88.5% white) with mean ± SD age of 52.6 ± 15.1 years who underwent both esthesioneuroblastoma surgery and adjuvant radiotherapy were queried. Median DTI, DTE, SRT, RTD, and TTP were 34, 140, 55, 45, and 101 days, respectively. A significant association was identified between increased regional radiation dose above 66 Gy and decreased DTI (OR = 0.54, 95% CI 0.35–0.83, p = 0.01) and increased RTD (OR = 3.94, 95% CI 2.36–6.58, p < 0.001) durations. Chemotherapy administration was linked with decreased SRT (OR = 0.64, 95% CI 0.47–0.89, p = 0.01) and TTP (OR = 0.59, 95% CI 0.43–0.82, p = 0.001) durations. Cox proportional‐hazards analysis revealed that increased RTD was associated with decreased survival (HR = 1.80, 95% CI 1.26–2.57, p < 0.005), independent of age, sex, race, regional radiation dose, facility volume, facility type, insurance status, modified Kadish stage, chemotherapy status, Charlson‐Deyo comorbidity index, and surgical margins. Conclusions: Delays during, and prolongation of radiotherapy for esthesioneuroblastoma appears to be associated with decreased survival. Level of Evidence: 4 Laryngoscope, 133:764–772, 2023 [ABSTRACT FROM AUTHOR]
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- 2023
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50. Nasal Cavity and Paranasal Sinus Tumors
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Fan, Ming, Yu, Yao, Kang, Jung Julie, Lee, Nancy Y., Lee, Nancy Y., Series Editor, Lu, Jiade J., Series Editor, and Yu, Yao, editor
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- 2022
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