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Background Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers. Methods We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women from 9 European countries, aged mostly 35–65 years at recruitment (1990–2000) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results After a median follow-up of 15.3 years, 47,110 incident cancer cases were recorded. PC1 (overall adiposity) was positively associated with the risk of overall cancer, with a HR per 1 standard deviation (SD) increment equal to 1.07 (95% confidence interval 1.05 to 1.08). Positive associations were observed with 10 cancer types, with HRs (per 1 SD) ranging from 1.36 (1.30–1.42) for endometrial cancer to 1.08 (1.03–1.13) for rectal cancer. PC2 (tall stature with low WHR) was positively associated with the risk of overall cancer (1.03; 1.02–1.04) and five cancer types which were not associated with PC1. PC3 (tall stature with high WHR) was positively associated with the risk of overall cancer (1.04; 1.03–1.05) and 12 cancer types. PC4 (high BMI and weight with low WC and HC) was not associated with overall risk of cancer (1.00; 0.99–1.01). Conclusions In this multi-national study, distinct body shape phenotypes were positively associated with the incidence of 17 different cancers and overall cancer.

Aim: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. Methods: This cross-sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters. Results: We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053).No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content. Conclusion: Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association. This study was mainly supported by grants from the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011), European Regional Development Fund (ERDF) of the European Commission (No 667302) and the Alicia Koplowitz Foundation. Additional funding was obtained from the Andalusian Operational Programme supported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). Additional support was obtained from University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence, Unit of Excellence on Exercise and Health, the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (SOMM17/6107/UGR); the EXERNET Research Network on Exercise and Health in Special populations (DEP2005-00046/ACTI); and the HL-PIVOT network - Healthy Living for Pandemic Event Protection. Funding for open access charge: Universidad de Granada / CBUA.

The relationship between inflammatory markers and bone turnover in adults is well known, whilst a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5±5.0 yrs, 62.7% women) were included in the analysis. CRF was measured by the six-minute walking test. Serum interleukine (IL)-1β, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP) and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy x-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers and bone turnover markers, controlling for sex, lean mass and fat mass. Boot-strapped mediation procedures were performed and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r=0.228, p=0.044) and osteocalcin levels (r=0.296, p=0.009). Furthermore, CRF was positively correlated with IL-1β levels (r=0.340, p=0.002) and negatively correlated with hsCRP levels (r=-0.335, p=0.003), whereas IL-1β levels were positively correlated with P1NP levels (r=0.245, p=0.030) and hsCRP levels were negatively correlated with P1NP levels (r=-0.319, p=0.004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (PM=39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population., Heart and Diseases Foundation (Fondation 234 Coeur et Artères) 59200 Loos, France

This study investigated the effects of a 10-month high-intensity interval-type neuromuscular training programme on musculoskeletal fitness in overweight and obese women. Forty-nine inactive females (36.4 ± 4.4 yrs) were randomly assigned to either a control (N = 21), a training (N = 14, 10 months) or a training-detraining group (N = 14, 5 months training followed by 5 months detraining). Training used progressive loaded fundamental movement patterns with prescribed work-to-rest intervals (1:2, 1:1, 2:1) in a circuit fashion (2-3 rounds). Muscular strength and endurance, flexibility, passive range of motion (PRoM), static balance, functional movement screen (FMS) and bone mass density (BMD) and content (BMC) were measured at pre-, mid-, and post-intervention. Ten months of training induced greater changes than the controls in (i) BMD (+1.9%

Objective This study aimed to 1) analyze the criterion validity of the Slaughter equations (Slg-Eq) and bioelectrical impedance analysis (BIA) to estimate body fat percentage (BFP) and fat mass index (FMI) at different degrees of obesity in children compared with dual-energy x-ray absorptiometry (DXA) and 2) determine their agreement over time. Methods Ninety-two children with overweight or obesity (10.0 [SD 1.2] years; 34.8% girls) participated in this 20-week study. Anthropometric, BIA, and DXA measurements were performed. Results Both Slg-Eq and BIA methods underestimated BFP and FMI against DXA, and the bias was markedly larger with BIA (mean absolute percentage error = 11% for Slg-Eq vs. 18%-21% for BIA); a larger underestimation was observed in girls compared with boys for Slg-Eq (P ≤ 0.001), and the observed underestimation in adiposity was reduced as weight status increased. Systematic errors were kept constant over time, so no large differences between methods were observed in the change in adiposity. Conclusions At the group level, Slg-Eq provides a more valid estimation of BFP and FMI than BIA. At the individual level, Slg-Eq shows larger estimation errors. The validity of these methods might differ in sex and weight status. Nevertheless, both methods seem to be valid for monitoring changes in adiposity.

E.U.G. is supported by the Programa Operativo Fondo Social Europeo (FSE) de Andalucia (2014-2020) and Junta de Andalucia (reference DOC_01618). D.P. is supported by a Juan de la Cierva Fellowship from the Ministry of Science and the National Research Agency of Spain (MCIN/AEI, JC2019-039691-I, http://dx.doi.org/10.13039/501100011033 (accessed on 20 February 2021))., Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention., Programa Operativo Fondo Social Europeo (FSE) de Andalucia (2014-2020), Junta de Andalucia DOC_01618, Juan de la Cierva Fellowship from the Ministry of Science, National Research Agency of Spain (MCIN/AEI) JC2019-039691-I

FundingE.U.-G. is supported by the Programa Operativo Fondo Social Europeo (FSE) de Andalucia (20142020) and Junta de Andalucia (reference DOC_01618)., The European Prospective Investigation into Cancer and Nutrition (EPIC) is a multicentre prospective study conducted in 23 centres in 10 European countries. Here we review the findings from EPIC on the relationship between diet-related exposures and incidence or mortality from the four most frequent cancers in the European population: colorectal, breast, lung, and prostate cancer. We conducted a systematic review following PRISMA guidelines and identified 110 high-quality studies based on the EPIC cohort. Fruit and vegetable consumption had a protective effect against colorectal, breast, and lung cancer, whereas only fruit had a protective effect against prostate cancer. A higher consumption of fish and lower consumption of red and processed meat were related with a lower risk of colorectal cancer; and higher consumption of fatty fish with lower risk of breast cancer. Calcium and yogurt intake were found to protect against colorectal and prostate cancer. Alcohol consumption increased the risk for colorectal and breast cancer. Finally, adherence to the Mediterranean diet emerged as a protective factor for colorectal and breast cancer. The EPIC study results are in agreement with the latest evidence from leading authorities on cancer prevention and help to inform public prevention policies and strategies., Programa Operativo Fondo Social Europeo (FSE) de Andalucia (20142020), Junta de Andalucia DOC_01618

The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p &gt, 0.05), however, we found cortical bone impairment (−7.3% to −8.4%, effect size (ES) = 0.78) in AGHD patients (p &lt, 0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (−8.5% to −16.2%, ES = 1.22 to 1.24) with acromegaly patients (p &lt, 0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.

This study aimed to identify the mediating effect of lean soft tissue (LST) in the association between somatic maturation and areal bone mineral density (aBMD) in adolescents by sex and sport participation. The sample included 558 adolescents (401 males, mean age of 14.0 years) that were practitioners of sports (11 sport modalities, n = 402) and a non-sport group (n = 157). Somatic maturation was assessed by using a validated peak height velocity prediction equation. Dual-energy X-ray absorptiometry (DXA) was used to assess aBMD (upper and lower limbs, spine and total body less head—TBLH) and LST. For both sexes, LST mediated the association between somatic maturation and aBMD at all skeletal sites (mediation percentage ranging from 36.3% to 75.4%). For sport and non-sport groups, the LST also mediated the association between somatic maturation and aBMD at all skeletal sites (mediation percentage ranging from 51.6% to 85.6%). The direct effect was observed in all groups, except for lower limbs and TBLH in the non-sport group. The association between somatic maturation and aBMD was mediated by LST in adolescents of both sexes and regardless of involvement in organized sports. Our findings highlighted the role of improving LST to mitigate the association of somatic maturation with aBMD., São Paulo Research Foundation (FAPESP) (FAPESP Process 2013/06963-5, 2015/13543-8, 2016/06920-2, 2017/09182-5, 2018/24164-6 and 2015/19710-3), FAPESP (2017/27234-2), FAPESP (2016/20354-0), “La Caixa” Foundation within the Junior Leader fellowship programme (ID 100010434; code LCF/BQ/PR19/11700007)

OBJECTIVES: Research investigating the longitudinal effects of the most popular sports on bone development in adolescent males is scarce. The aim is to investigate the effect of 12-month participation in osteogenic and non-osteogenic sports on bone development.DESIGN: A 12-month study was conducted in adolescent males involved in football, swimming and cycling and compared with an active control group.METHODS: 116 adolescent males (13.1±0.1years at baseline): 37 footballers, 37 swimmers, 28 cyclists and 14 active controls were followed for 12 months. Bone mineral content (BMC) was measured by dual-energy X-ray absorptiometry, and bone stiffness was measured by quantitative ultrasound. Bone outcomes at 12 months were adjusted for baseline bone status, age, height, lean mass and moderate to vigorous physical activity.RESULTS: Footballers had higher improvement in adjusted BMC at the total body, total hip, shaft, Ward's triangle, legs and bone stiffness compared to cyclists (6.3-8.0%). Footballers had significantly higher adjusted BMC at total body, shaft and legs compared to swimmers (5.4-5.6%). There was no significant difference between swimmers and cyclists for any bone outcomes. Swimming and cycling participation resulted in non-significant lower bone development at most sites of the skeleton compared to controls (-4.3 to -0.6%).CONCLUSIONS: Football participation induces significantly greater improvements in BMC and bone stiffness over 12 months compared to cycling and swimming.CLINICAL TRIAL REGISTRATION: ISRCTN17982776.

The aim of this research was to evaluate the influence of game surface and pitch size on the physiological responses, jump performance and perceptions of sub-elite female soccer players playing four-a-side games. Sixteen sub-elite female soccer players were divided into four groups of four players each. Three small-sided games (SSGs; pitch size: 400 m2, 600 m2 and 800 m2) were played on three surfaces (dirt [DT], artificial turf [AT] and natural grass [NG]). Players’ heart rate (HR) was monitored during each game. Before and after each SSG, participants performed two counter-movement jumps (CMJs) and answered a questionnaire based on visual analogue scales (VASs) to indicate their perception of the effort required on each surface. DT obtained lower outputs for most variables. In the SSG 600 mean HR was higher on NG than AT (+3.31 %HRmax; p = 0.029), but players’ overall satisfaction with both surfaces was similar (p>0.05). The SSG 400 received the lowest ratings for most variables, whereas the SSG 600 resulted in higher mean HR than SSG 800 [NG (+9.14 b.p.m.; p = 0.001); AT (+7.32 b.p.m.; p = 0.014)]. No surface differences in CMJ performance were found. In conclusion, a higher internal load can be achieved on NG, whereas DT is not recommended for playing soccer. Moreover, the internal load on players in SSGs can be controlled by manipulating pitch size, but over-large pitches may entail a reduction in the physiological profile of female soccer players. Sin financiación 2.202 JCR (2018) Q2, 33/83 Sport Sciences 0.941 SJR (2018) Q1, 64/289 Orthopedics and Sports Medicine, 39/209 Physical Therapy, Sports Therapy and Rehabilitation; Q2, 46/108 Physiology (medical), 47/125 Sports Science No data IDR 2018 UEM

Physical activity plays a crucial role in bone mass acquisition during childhood and adolescence, with weightbearing and high-impact sport activities being more beneficial. This study sought to evaluate the impact of different sports activities on bone mineral density and content in male Portuguese athletes. Seventy adolescent boys (aged 12-15 years) including 28 futsal players (FG), 20 swimmers (SG) and 22 non-athletic adolescents used as control subjects (CG), participated in the current study. Areal bone mineral density (aBMD) and areal bone mineral content (aBMC) were measured by dual energy x-ray absorptiometry (DEXA). Futsal players had significantly higher aBMD (lumbar spine - FG: 0.95 ± 0.18, SG: 0.80 ± 0.13, CG: 0.79 ± 0.13 g/cm2, p = 0.001; pelvis - FG: 1.17 ± 0.21, SG: 0.91 ± 0.12, CG: 0.98 ± 0.10 g/cm2, p < 0.001; lower limbs - FG: 1.21 ± 0.19, SG: 0.97 ± 0.10, CG: 0.99 ± 0.09 g/cm2, p < 0.001) and aBMC (lumbar spine - FG: 51.07 ± 16.53, SG: 40.19 ± 12.47, CG: 40.50 ± 10.53 g, p = 0.013; pelvis - FG: 299.5 ± 110.61, SG: 170.02 ± 55.82, CG: 183.11 ± 46.78 g, p < 0.001; lower limbs - FG: 427.21 ± 117.11, SG: 300.13 ± 76.42, CG: 312.26 ± 61.86 g/cm2, p < 0.001) than swimmers and control subjects. Data suggest that futsal, as a weightbearing and high or odd-impact sport, may improve bone mass during childhood and adolescence.

The Artificial Athlete (AA) and the Advanced Artificial Athlete (AAA) devices are the two key test methods for the assessment of shock absorption (SA) and vertical deformation (VD) of sports surfaces. The aim of this study was to investigate the relationship between them. Laboratory tests were carried out in accordance with international regulations and standards on 50 athletics tracks and 44 artificial turf systems using both test methods. No significant differences between methods were observed. Measurements with the AA and the AAA were compared using intraclass correlation coefficients (ICCs), showing acceptable to excellent inter-method reliability (ICC ranged from 0.47 to 0.91). The Bland-Altman test revealed an overall SA overestimation and VD underestimation with the AAA. Linear regression analysis was performed, obtaining excellent agreement between test methods for the assessment of SA (R2 = 0.994) and VD (R2 = 0.985). It is concluded that, by applying Equations (1) and (2) in this study, the AA and the AAA could be used interchangeably when assessing SA and VD on athletics tracks and artificial turf surfaces. Sin financiación 2.247 JCR (2017) Q2, 10/33 Materials Science, Characterization and Testing, 28/87 Polymer Science 0.669 SJR (2017) Q1, 31/214 Polymers and Plastics; Q2, 72/187 Organic Chemistry No data IDR 2017 UEM

Adolescence is a crucial period for bone development, and exercise can enhance bone acquisition during this period of life. However, it is not known how the different loading sports practiced can affect bone acquisition in adolescent male athletes. Therefore, the purpose of the present study was to determine the 1-year longitudinal bone acquisition among adolescent males involved in osteogenic (football) and non-osteogenic (swimming and cycling) sports and to compare with active controls. A total of 116 adolescent males aged 12 to 14 years at baseline were followed for 1 year: 37 swimmers, 37 footballers, 28 cyclists, and 14 active controls. Bone mineral content (BMC) was assessed using dual-energy X-ray absorptiometry (DXA); cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), and section modulus (Z) at the femoral neck was assessed using hip structural analysis (HSA); and bone texture of the lumbar spine was assessed using trabecular bone score (TBS). Serum N-terminal propeptide of procollagen type I (PINP), isomer of the Carboxi-terminal telopeptide of type 1 collagen (CTX-I), total serum calcium, and 25 hydroxyvitamin D [25(OH)D] were analyzed. Footballers had significantly higher adjusted BMC at the lumbar spine (7.0%) and femoral neck (5.0%) compared with cyclists, and significantly greater BMC at the lumbar spine (6.9%) compared with swimmers. Footballers presented significantly greater TBS (4.3%) compared with swimmers, and greater CSMI (10.2%), CSA (7.1%), Z (8.9%) and TBS (4.2%) compared with cyclists. No differences were noted between cyclists and swimmers, both groups had similar bone acquisition compared with controls. PINP was significantly higher in footballers and controls compared with cyclists and swimmers (3.3% to 6.0%), and 25(OH)D was significantly higher in footballers and cyclists compared with swimmers and controls (9.9% to 13.1%). These findings suggest that bone acquisition is higher in adolescent male footballers compared with swimmers and cyclists at the femoral neck and lumbar spine sites of the skeleton. © 2017 American Society for Bone and Mineral Research.

Aim This study investigated the associations between fitness indices and bone outcomes in young males. Methods Data were collected between autumn and winter 2014-2015 on 121 males with a mean age of 13.1 ±0.1 years: 41 swimmers, 37 footballers, 29 cyclists and 14 non-athletes. Participants were recruited from athletic clubs and schools across South West England. Lean mass, areal bone mineral density and hip structural estimates were measured using dual-energy X-ray absorptiometry. The relationships between bone outcomes and the vertical jump, standing long jump and the 20m shuttle run test were analysed using three regression models: model one was adjusted by age and stature, model two added vigorous physical activity and model three then added lean mass. Results The boys’ performance in the vertical jump and standing long jump was positively associated with the majority of bone outcomes in models one and two, but most of these disappeared in model three. The 20m shuttle run test was positively associated with most bone outcomes in all three models. Lean mass played a key role in the association between muscular fitness and bone outcomes. Conclusion Vigorous physical activity did not explain the associations between fitness and bone outcomes, but lean mass did. This article is protected by copyright. All rights reserved.

The determinants of areal bone mineral density (aBMD) and hip geometry estimates in adolescent athletes are poorly understood. This study aimed to identify the determinants of aBMD and hip geometry estimates in adolescent male athletes.One hundred twenty-one men (13.1 ± 0.1 yr) were measured: 41 swimmers, 37 footballers, 29 cyclists, and 14 controls. Dual energy X-ray absorptiometry measured aBMD at lumbar spine, femoral neck and total body. Hip structural analysis evaluated hip geometry estimates at the femoral neck. Multiple linear regression examined the contribution of the sports practised, stature, lean and fat mass, serum calcium and vitamin D, moderate to vigorous physical activity, vertical jump and cardiorespiratory fitness with aBMD and hip geometry estimates.Region-specific lean mass was the strongest positive predictor of aBMD (β = 0.614-0.931) and football participation was the next strongest predictor (β = 0.304-0.579). Stature (β = 0.235-0.380), fat mass (β = 0.189), serum calcium (β = 0.103), serum vitamin D (β = 0.104-0.139), and vertical jump (β = 0.146-0.203) were associated with aBMD across various specific sites. All hip geometry estimates were associated with lean mass (β = 0.370 - 0.568) and stature (β = 0.338-0.430). Football participation was associated with hip cross-sectional area (β = 0.322) and moderate to vigorous physical activity (β = 0.140-0.142). Cardiorespiratory fitness (β = 0.183-0.207) was associated with section modulus and cross-sectional moment of inertia.Region-specific lean mass is the strongest determinant of aBMD and hip geometry estimates in adolescent male athletes. Football participation and stature were important determinants for aBMD and hip geometry estimates, whereas the contribution of the other predictors was site specific.

PurposeThe aim of this study was to analyze and compare the effects of different sports (swimming, football, basketball, and handball) on fat mass and lean mass in prepubertal and pubertal girls.MethodsTwo hundred girls (10.6 ± 1.5 years old, Tanner stages I–III) participated in the study and were divided into five groups: 40 swimmers, 40 football players, 40 basketball players, 40 handball players, and 40 controls. Fat and lean masses at whole body, arms, trunk, and legs were measured using dual-energy X-ray absorptiometry (DXA). Pubertal status was determined using Tanner test. Effects of different sports on fat and lean masses were assessed through analysis of covariance with height as covariates. Analyses were performed separately in two groups depending on the Tanner stage (prepubertal and pubertal).ResultsThe girls of the control group had less lean mass and more fat mass compared to the girls who play sports (p

Soft tissues, such as fat mass (FM) and lean mass (LM), play an important role in bone development but this is poorly understood in highly active youths. The objective of this study was to determine whether FM or LM is a stronger predictor of areal bone mineral density (aBMD) and hip geometry estimates in a group of physically active boys after adjusting for height, chronological age, moderate-to-vigorous physical activity (MVPA), FM, and LM. Participants included 121 boys (13.1 ± 1.0 years) from the PRO-BONE study. Bone mineral content (BMC) and aBMD were measured at total body, femoral neck and lumbar spine using dual-energy X-ray absorptiometry (DXA), and hip structural analysis was used to estimate bone geometry at the femoral neck. Body composition was assessed using DXA. The relationships of FM and LM with bone outcomes were analysed using simple and multiple linear regression analyses. Pearson correlation coefficients showed that total body (less head) aBMD was significantly correlated with LM but not FM. Multiple linear regression analyses showed that FM, after accounting for height, age, MVPA and LM had no significant relationship with aBMD or hip geometry estimates, except for arms aBMD. By contrast, there were positive associations between LM and most aBMD and hip geometry estimates, after accounting height, age, MVPA and FM. The results of this study suggest that LM, and not FM, is the stronger predictor of aBMD and hip geometry estimates in physically active boys. ClinicalTrials.gov ISRCTN17982776.

A correction to this paper has been published and can be accessed via a link at the top of the paper.

Background: New approaches on paediatric cancer treatment aim to maintain long-term health. As a result of radiotherapy, chemotherapy or surgery, paediatric cancer survivors tend to suffer from any chronic health condition. Endocrine dysfunction represents one of the most common issues and affects bone health. Exercise is key for bone mass accrual during growth, specifically plyometric jump training. The iBoneFIT study will investigate the effect of a 9-month online exercise programme on bone health in paediatric cancer survivors. This study will also examine the effect of the intervention on body composition, physical fitness, physical activity, calcium intake, vitamin D, blood samples quality of life and mental health. Methods: A minimum of 116 participants aged 6 to 18 years will be randomized into an intervention (n = 58) or control group (n = 58). The intervention group will receive an online exercise programme and diet counselling on calcium and vitamin D. In addition, five behaviour change techniques and a gamification design will be implemented in order to increase the interest of this non-game programme. The control group will only receive diet counselling. Participants will be assessed on 3 occasions: 1) at baseline; 2) after the 9 months of the intervention; 3) 4 months following the intervention. The primary outcome will be determined by dual energy X-ray absorptiometry (DXA) and the hip structural analysis, trabecular bone score and 3D-DXA softwares. Secondary outcomes will include anthropometry, body composition, physical fitness, physical activity, calcium and vitamin D intake, blood samples, quality of life and mental health., La Caixa Foundation 100010434 LCF/BQ/PR19/11700007, University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), Junta de Andalucía SOMM17/6107/UGR, European Union (EU) SOMM17/6107/UGR

Context Primary hyperparathyroidism (PHPT) has been related to bone loss. Dual-energy x-ray absorptiometry (DXA) cannot distinguish between trabecular and cortical bone compartments but the recently developed three-dimensional (3D)-DXA software might overcome this issue. Objective To examine the differences in DXA-derived areal bone mineral density (aBMD) and 3D-DXA parameters at the hip site between patients with PHPT and a healthy control group. Design Cross-sectional pilot study Setting Hospital Patients 80 adults (59.5 ± 9.1 yrs), 40 with PHPT and 40 age- and sex-matched healthy controls. Measures aBMD (g/cm2) of the femoral neck, trochanter, shaft, and total hip was assessed using DXA. Cortical surface (sBMD, mg/cm2), cortical volumetric BMD (vBMD, mg/cm3), trabecular vBMD (mg/cm3), integral vBMD (mg/cm3) and cortical thickness (mm) was assessed using 3D-DXA software. Results Mean-adjusted values showed lower aBMD (7.5%-12.2%, effect size: 0.51-1.01) in the PHPT group compared with the control group (all P < 0.05). 3D-DXA revealed bone impairment (3.7%-8.5%, effect size: 0.47-0.65) in patients with PHPT, mainly in cortical parameters (all P < 0.05). However, differences in trabecular vBMD were not statistically significant (P = 0.055). The 3D mapping showed lower cortical sBMD, cortical vBMD, and cortical thickness at the trochanter and diaphysis in the PHPT group (P < 0.05) compared with the control group. In both groups, the presence of osteopenia or osteoporosis is related to lower cortical bone. Conclusions aBMD and cortical 3D parameters are impaired in patients with PHPT versus healthy controls. The vBMD of the trabecular compartment seems to be affected, although to a lesser extent.

The association between vitamin D [25(OH)D] and bone health has been widely studied in children. Given that 25(OH)D and bone health are associated with muscular fitness, this could be the cornerstone to understand this relationship. Hence, the purpose of this work was to examine if the relation between 25(OH)D and areal bone mineral density (aBMD) was mediated by muscular fitness in children with overweight/obesity. Eighty-one children (8-11 years, 53 boys) with overweight/obesity were included. Body composition was measured with dual energy X-ray Absorptiometry (DXA), 25(OH)D was measured in plasma samples and muscular fitness was assessed by handgrip and standing long jump tests (averaged z-scores were used to represent overall muscular fitness). Simple mediation analyses controlling for sex, years from peak height velocity, lean mass and season were carried out. Our results showed that muscular fitness z-score, handgrip strength and standing long jump acted as mediators in the relationship between 25(OH)D and aBMD outcomes (percentages of mediation ranged from 49.6% to 68.3%). In conclusion, muscular fitness mediates the association of 25(OH)D with aBMD in children with overweight/obesity. Therefore, 25(OH)D benefits to bone health could be dependent on muscular fitness in young ages., This study was supported by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540). This study takes place thanks to the additional funding from the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence actions: Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES) and the European Regional Development Funds (ERDF, ref. SOMM17/6107/UGR). In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF) (Ref. RD16/0022). L.G-M is supported by a fellowship from “la Caixa” Foundation (ID 100010434) and the fellowship code is LCF/BQ/PR19/11700007. J.H.M. and J.M.-G. are supported by the Spanish Ministry of Education, Culture and Sport (FPU15/02645 and FPU14/06837, respectively).

Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Methods Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8–11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. Results IL-6 (β = −0.136) and VEGF (β = −0.099) were associated with TBLH BMC, while TNF-α (β = −0.345) and IL-1β (β = 0.212) were associated with LS BMC (P

To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.IL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = -0.152) and TNF-α with LS BMC (β = -0.491) in the low-fitness group, while no association was found in the high-fitness group.IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.

Na literatura sobre as políticas desportivas verifica-se uma diversidade de estudos referentes à importância do desporto na comunidade, nos quais os municípios emergem como um dos principais catalisadores do desenvolvimento desportivo local. Em Moçambique, os estudos neste âmbito são escassos e dispersos. Assim, na presente investigação, pretendemos identificar e caraterizar as políticas desportivas encetadas em municípios de Moçambique, tendo em atenção as suas categorias e os seus contextos. Recorremos à triangulação metodológica por meio da análise documental, aplicação de entrevistas semiestruturadas e questionários a 24 responsáveis pelo desporto, em 12 municípios do território nacional, classificados em categorias A, B, C e D em função de fatores socioeconómicos, socioculturais e sociodemográficos. Os resultados sugerem semelhanças na abordagem política assumida para a generalização da prática desportiva, nos modelos de definição e desenvolvimento das políticas, no relacionamento com outras entidades, na gestão de informação e na gestão financeira. As diferenças encontradas dizem respeito ao modo da avaliação das políticas desportivas. As conclusões ressaltam (i) ausência de programas desportivos diversificados e planos estratégicos de desenvolvimento desportivo, pelo que é necessária maior colaboração intermunicipal para a efetivação dos objetivos, assim como (ii) definição de critérios de apoio a programas que sejam identificados de utilidade pública. Sin financiación No data JCR 2017 No data SJR 2017 No data IDR 2017 UEM

The aim of this study was to analyze the influence of natural turf, artificial turf, and sand on sprint performance in different sports and to determine how the sport surface affects sprint performance. A systematic search was conducted in Pubmed, Web of Sciences, and SPORTDiscus databases. Out of 5644 studies, 11 studies were included in the meta-analysis. The studies were very heterogeneous, as they examined different structural characteristics or quality parameters. The studies on natural turf and sand showed significant improvements on sprint speed during training. On the other hand, the analysis of fatigue did not reveal significant differences in the deterioration of sprint speed on both natural and artificial turf. Significance was set at p < 0.05. In conclusion, although lower performance in sprint was reported on sand, further studies are needed to explain the differences in sprint on natural and artificial turf. SIN FINANCIACIÓN 3.390 JCR (2020) Q1, 41/176 Public, Environmental & Occupational Health 0.747 SJR (2020) Q2, 50/137 Health, Toxicology and Mutagenesis No data IDR 2019 UEM

To examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children and to examine the role of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF) in this association.A cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2 years) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen's metabolic syndrome cut-off points for triglycerides, glucose, high-density cholesterol and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-m shuttle run test, respectively. Body composition was measured by dual-energy X-ray absorptiometry.In model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen's d effect size, ES = 0.34), trunk (ES = 0.43) and pelvis (ES = 0.33) than MUO children. These differences were attenuated once MVPA was added to model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3).This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF seem to partially explain these findings.

Background and objectives: Regular exercise may stimulate bone formation and reduce the loss of bone mass in premenopausal women. This study aims to evaluate the effect of high-impact physical activity (Zumba&reg, ) and low-impact physical activity (Aquagym) on bone mass in inactive middle-aged women. Materials and methods: Fifty-five healthy inactive women (30&ndash, 50 years old) were recruited in Spain in 2016 and were randomly allocated into one of three groups: High impact group (HIG: n = 15), low impact group (LIG: n = 12) and control group (CG: n = 28). HIG and LIG were recruited from Madrid and the CG from Toledo. HIG and LIG completed a 12-week intervention program with three 40&prime, sessions per week of Zumba&reg, or Aquagym, respectively. Dual energy X-ray absorptiometry (DXA) measured bone mineral content (BMC) and areal bone mineral density (aBMD) at total body less head (TBLH), lumbar spine and right hip. Results: Post-intervention adjusted data showed no significant differences in BMC between any of the groups nor in aBMD between HIG and LIG. Interestingly, significant differences for the HIG vs. CG were found in the change in total hip aBMD (1.76% vs. &minus, 0.44%), femoral neck aBMD (1.80% vs. &minus, 2.71%), and intertrochanter aBMD (2.03% vs. &minus, 0.50%). Moreover, significant differences for the LIG vs. CG were also found in the change in femoral neck aBMD (&minus, 0.54% vs. &minus, 2.71%). Conclusions: The regular practice of Zumba&reg, and Aquagym might reduce the progressive deterioration of bone mass in inactive middle-aged women

Objectives: To examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children and to examine the role of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF) in this association. Methods: A cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2 years) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen’s metabolic syndrome cut-off points for triglycerides, glucose, high-density cholesterol and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-m shuttle run test, respectively. Body composition was measured by dual-energy X-ray absorptiometry. Results: In model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen’s d effect size, ES = 0.34), trunk (ES = 0.43) and pelvis (ES = 0.33) than MUO children. These differences were attenuated once MVPA was added to model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3). Conclusions: This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF seem to partially explain these findings. This study has been partially funded by the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme: Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES), and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Enterprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. The ActiveBrains study was funded by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP). The EFIGRO study was funded by the Spanish Ministry of Health, 'Fondo de Investigación Sanitaria del Instituto de Salud Carlos III' (PI13/01335), 'Fondos Estructurales de la Unión Europea (FEDER), Una manera de hacer Europa,' and by the University of the Basque Country (GIU14/21). L.G.-M. is supported by 'La Caixa' Foundation within the Junior Leader fellowship programme (ID 100010434); M.M. is supported by the Spanish Ministry of Education, Culture and Sport (FPU14/03329) and EST17/00210; L.A. is supported by the Education Department of the Government of the Basque Country (PRE_2016_1_0057, PRE_2017_2_0224 and PRE_2018_2_0057); J.M.-G. and J.H.M. are supported by the Spanish Ministry of Education, Culture and Sport (FPU14/06837 and FPU15/02645, respectively).

Lean mass is a strong determinant of bone mass, however, there is controversial surrounding the role of fat mass. The aim of this study was to examine the association between lean mass and fat mass with bone mass in middle-aged sedentary women, including relevant covariates. A cross-sectional study was performed on a total of 55 healthy and sedentary women. Dual energy x-ray absorptiometry was used to measure bone mineral content and areal bone mineral density at the whole body, lumbar spine and hip. The relationships between lean and fat mass with bone outcomes were analysed using three regression models: model 0 using unadjusted data, model 1 was adjusted by age and stature and model 2 added lean mass or fat mass (depending on the predictor). Lean mass was positively associated with most bone mineral content and areal bone mineral density outcomes in models 0 and 1, and the majority of these associations remained significant in model 2 (after adjusted by fat mass). Fat mass was positively associated with some of the bone mineral content and areal bone mineral density outcomes in models 0 and 1, and interestingly all associations disappeared in model 2 (after adjusted by lean mass). The main finding of this study was that lean mass was positively related to bone outcomes, independent of age, stature and fat mass in middle-aged sedentary women. In addition, the association between fat mass and bone outcomes seems to be explained by lean mass. 2016/UEM10. No data JCR 2019 0.403 SJR (2019) Q2, 99/213 Physical Therapy, Sports Therapy and Rehabilitation 0,746 IDR (2019) C2, 15/45 Deporte UEM