1. Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery?
- Author
-
Jena L. Miller, Ahmet Baschat, Philip DeKoninck, Femke Slaghekke, Esther J Oldekamp, Jan Deprest, Dick Oepkes, Alex J. Eggink, Martine C. de Vries, Jochem K H Spoor, and E. Joanne Verweij
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Meningomyelocele ,MEDLINE ,Review ,030105 genetics & heredity ,Neurosurgical Procedures ,Scientific evidence ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Pregnancy ,Medicine ,Humans ,Closure (psychology) ,Spinal Dysraphism ,Genetics (clinical) ,Alternative methods ,Genetics & Heredity ,030219 obstetrics & reproductive medicine ,Science & Technology ,business.industry ,Spina bifida ,Fetoscopy ,Gold standard ,Obstetrics and Gynecology ,Obstetrics & Gynecology ,medicine.disease ,Surgery ,Female ,business ,Surgical interventions ,Life Sciences & Biomedicine - Abstract
Since the completion of the Management of Myelomeningocoele Study, maternal‐fetal surgery for spina bifida has become a valid option for expecting parents. More recently, multiple groups are exploring a minimally invasive approach and recent outcomes have addressed many of the initial concerns with this approach. Based on a previously published framework, we attempt to delineate the developmental stage of the surgical techniques. Furthermore, we discuss the barriers of performing randomized controlled trials comparing two surgical interventions and suggest that data collection through registries is an alternative method to gather high‐grade evidence., Key Points What's already known about this topic? The use of fetoscopy for spina bifida repair is adopted by an increasing number of centers worldwide. On the other hand, its efficacy has not been established within a randomized controlled trial and thus it is still considered experimental by others. What does this study add? Herein we describe a framework which could be used to determine the developmental stage of novel interventions in the field of maternal‐fetal surgery. Furthermore, we discuss the difficulties of gathering high level evidence for a fetoscopic closure of the spinal defect in fetuses with a spina bifida.
- Published
- 2021