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Your search keyword '"Ester del Barco"' showing total 2 results
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2 results on '"Ester del Barco"'

1. Cervical cerclage vs cervical pessary in women with cervical insufficiency: A multicentric, open-label, randomised, controlled pilot trial [the CEPEIC trial]

Author

Andrea Gascón, Nerea Maiz, Maia Brik, Manel Mendoza, Ester del Barco, Elena Carreras, and Maria Goya

Subjects
Cervical insufficiency, Preterm birth, Cervical pessary, Cervical cerclage, Gynecology and obstetrics, RG1-991
Abstract

Objective: Cervical insufficiency accounts for 8 % of preterm births. Pessary and cerclage are considered preventive approaches for preterm birth. These interventions were compared in terms of reducing the prematurity rate in women with previous preterm birth, due to cervical insufficiency or due to having a short cervix in their current pregnancy. Methods: This was a prospective, multicentric, open-label, randomised, pilot, controlled trial. Participants were women with singleton pregnancies who had previous preterm birth caused by cervical insufficiency or previous preterm birth and a short cervix [≤ 25 mm] in their current pregnancy. Women were randomised [1:1] to either cerclage or pessary. The primary outcome was to assess the feasibility of a trial on cervical pessary vs. cerclage to prevent preterm birth before 34 weeks in women with cervical insufficiency. As a secondary outcome, we studied the morbidity rate of the pessary versus the cerclage in women with cervical insufficiency and assessed the financial impact of using both devices in these women. The sample size was calculated based on the estimated population that we could potentially recruit: 60 women, 30 for each group, to ascertain whether the rate of preterm birth

Published
2024
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2. Reference values for interleukin-6 in the amniotic fluid of asymptomatic pregnant women

Author

Ester del Barco, Clara Franco‐Jarava, Mireia Vargas, Nerea Maíz, Silvia Arevalo, Maria Ángeles Sánchez, Maria Teresa Avilés, Carlota Rodó, Manel Mendoza, Maria Goya, Manuel Hernández‐González, Elena Carreras, Institut Català de la Salut, [Del Barco E, Vargas M, Maíz N, Arevalo S, Sánchez MÁ, Avilés MT, Rodó C, Mendoza M] Unitat de Medicina Materna i Fetal, Servei d’Obstetrícia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Franco-Jarava C, Hernández-González M] Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Goya M, Carreras E] Unitat de Medicina Materna i Fetal, Servei d’Obstetrícia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Maternal and Child Health and Development Network (SAMID), Instituto Salud Carlos III, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Fetal Diseases::Chorioamnionitis [DISEASES], estructuras embrionarias::feto::líquido amniótico [ANATOMÍA], Líquid amniòtic, Fluids and Secretions::Amniotic Fluid [ANATOMY], Persons::Women::Pregnant Women [NAMED GROUPS], Infecció, Obstetrics and Gynecology, Embaràs - Complicacions, General Medicine, enfermedades de los genitales femeninos y complicaciones del embarazo::complicaciones del embarazo::enfermedades fetales::corioamnionitis [ENFERMEDADES], personas::mujeres::mujeres embarazadas [DENOMINACIONES DE GRUPOS]
Abstract

Amniocentesis; Interleukin-6; Intra-amniotic inflammation Amniocentesi; Interleucina-6; Inflamació intraamniòtica Amniocentesis; Interleucina-6; Inflamación intraamniótica Introduction Nowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin-6 (IL-6) levels in the amniotic fluid and to identify factors which may alter this value. Material and methods Prospective study in a tertiary-level center including asymptomatic pregnant women undergoing amniocentesis for genetic studies from October 2016 to September 2019. IL-6 measurements in amniotic fluid were performed using a fluorescence immunoassay with microfluidic technology (ELLA Proteinsimple, Bio Techne). Maternal history and pregnancy data were also recorded. Results This study included 140 pregnant women. Of those, women who underwent termination of pregnancy were excluded. Therefore, a total of 98 pregnancies were included in the final statistical analysis. The mean gestational age was 21.86 weeks (range: 15–38.7) at the time of amniocentesis, and 38.6 weeks (range: 30.9–41.4) at delivery. No cases of chorioamnionitis were reported. The log10 IL-6 values follow a normal distribution (W = 0.990, p = 0.692). The median, and the 5th, 10th, 90th, and 95th percentiles for IL-6 levels were 573, 105, 130, 1645, and 2260 pg/mL, respectively. The log10 IL-6 values were not affected by gestational age (p = 0.395), maternal age (p = 0.376), body mass index (p = 0.551), ethnicity (p = 0.467), smoking status (p = 0.933), parity (p = 0.557), method of conception (p = 0.322), or diabetes mellitus (p = 0.381). Conclusions The log10 IL-6 values follow a normal distribution. IL-6 values are independent of gestational age, maternal age, body mass index, ethnicity, smoking status, parity and method of conception. Our study provides a normal reference range for IL-6 levels in the amniotic fluid that can be used in future studies. We also observed that normal IL-6 values were higher in the amniotic fluid than in serum. Some of the authors are members of the European Reference Network on Rare Congenital Malformations and Rare Intellectual Disability ERN-ITHACA (EU Framework Partnership Agreement ID: 3HP-HP-FPA ERN-01-2016/739516).

Published
2023

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