Search

Your search keyword '"Estell, Krista"' showing total 33 results
Start Over Author "Estell, Krista"
33 results on '"Estell, Krista"'

1. Prospective pre- and post-race evaluation of biochemical, electrophysiologic, and echocardiographic indices in 30 racing thoroughbred horses that received furosemide

Author

Gunther-Harrington, Catherine T, Arthur, Rick, Estell, Krista, Martinez Lopez, Beatriz, Sinnott, Alexandra, Ontiveros, Eric, Varga, Anita, and Stern, Joshua A

Subjects
Clinical Research, Cardiovascular, Prevention, Heart Disease, Animals, Biomarkers, Diuretics, Echocardiography, Electrocardiography, Female, Furosemide, Heart Rate, Heart Valve Diseases, Horses, Male, Prospective Studies, Reference Values, Running, Troponin I, Troponin, Cardiology, Sudden death, Cardiac ultrasound, Exercise, Biochemistry and Cell Biology, Microbiology, Veterinary Sciences
Abstract

BackgroundExercise induced cardiac fatigue (EICF) and cardiac dysrhythmias are well described conditions identified in high-level human athletes that increase in frequency with intensity and duration of exercise. Identification of these conditions requires an understanding of normal pre- and post-race cardiac assessment values. The objectives of this study were to (1) characterize selected indices of cardiac function, electrophysiologic parameters, and biochemical markers of heart dysfunction prior to and immediately after high level racing in Thoroughbred horses receiving furosemide; and (2) create pre- and post-race reference values in order to make recommendations on possible screening practices for this population in the future.ResultsThirty Thoroughbred horses were enrolled in the study with an age range of 3-6 years. All horses received furosemide prior to racing. Physical exams, ECGs, and echocardiograms were performed prior to racing (T0) and within 30-60 min following the race (T1). Blood samples were obtained at T0, T1, 4 h post-race (T4) and 24 h after the race (T24). Electrolytes, hematocrit, cardiac troponin I, and partial pressure CO2 values were obtained at all time points. Heart rate was significantly increased post-race compared to baseline value with a median difference of 49 bpm, 95% CI [31,58],(P

Published
2018

2. Current dorsal myelographic column and dural diameter reduction rules do not apply at the cervicothoracic junction in horses

Author

Estell, Krista, Spriet, Mathieu, Phillips, Kathryn L, Aleman, Monica, and Finno, Carrie J

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Physical Injury - Accidents and Adverse Effects, Traumatic Head and Spine Injury, Neurosciences, Animals, Cervical Vertebrae, Female, Horses, Male, Myelography, Neck, Spinal Cord Compression, Spinal Stenosis, cervical stenotic myelopathy, contrast column, dural diameter, vertebra, Animal production, Veterinary sciences
Abstract

Previously published myelographic studies do not report findings at the junction between the seventh cervical (C7) and first thoracic vertebrae (T1). Modern digital radiographic equipment allows improved visualization of C7-T1. Based on clinical experience, we hypothesized that 50% reduction of the dorsal myelographic column or 20% reduction of the dural diameter, criteria commonly used as a supportive finding for spinal cord compression in the cervical vertebral column, do not apply at C7-T1. A myelographic study was performed on 12 healthy, neurologically normal horses. Our hypothesis was confirmed; using established criteria eight of 12 horses would have been classified as having evidence of spinal cord compression at C7-T1. The dorsal myelographic column reduction at C7-T1 was 48 ± 12%, while the C6-C7 dorsal myelographic column reduction was 33 ± 17% (mean ± standard deviation) (P = 0.010). The dural diameter reduction at C7-T1 (22.0 ± 6.7%) was significantly greater than the dural diameter reduction at C6-C7 (13.2 ± 9.5%) (P = 0.0007). Further measurements and comparisons suggested that the apparent greater reduction of dorsal myelographic column and dural diameter at C7-T1 was due to larger intravertebral measurements at C7 rather than smaller intervertebral values at C7-T1. Based on these findings, alternative criteria should be used at C7-T1 when assessing clinical cases for cervical stenotic myelopathy. Reduction of the dorsal myelographic column by 60% or of the dural diameter by 30% would avoid high numbers of false positive myelographic cases at C7-T1.

Published
2018

3. Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy

Author

Finno, Carrie J, Estell, Krista E, Winfield, Laramie, Katzman, Scott, Bordbari, Matthew H, Burns, Erin N, Miller, Andrew D, Puschner, Birgit, Tran, Cecilia K, and Xu, Libin

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Neurosciences, Aging, Animals, Biomarkers, Female, Genetic Predisposition to Disease, Horse Diseases, Horses, Isoprostanes, Lipid Metabolism, Lipid Peroxidation, Lipids, Male, Neuroaxonal Dystrophies, ataxia, equine, genetics, vitamin E, Veterinary sciences
Abstract

BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet. Currently no antemortem diagnostic test for eNAD/EDM is available.HypothesisBecause α-TOH deficiency is associated with increased lipid peroxidation, it was hypothesized that F2 -isoprostanes (F2 IsoP), F4 -neuroprostanes (F4 NP) and oxysterols derived from free radical oxidation would be increased in the cerebrospinal fluid (CSF) and neural tissue of eNAD/EDM affected horses and could serve as potential biomarkers for disease.AnimalsIsoprostane Study A: 14 Quarter horse foals (10 healthy foals and 4 eNAD/EDM affected foals) at 1 and 6 months of age. Isoprostane Study B: 17 eNAD/EDM affected and 10 unaffected horses ≥ 1-4 years of age. Oxysterol study: eNAD/EDM affected (n = 14, serum; n = 11, CSF; n = 10, spinal cord [SC]) and unaffected horses 1-4 years of age (n = 12, serum; n = 10, CSF; n = 7, SC).ProceduresCerebrospinal fluid [F2 IsoP] and [F4 NP] were assessed using gas chromatography-negative ion chemical ionization mass spectrometry. Serum, CSF, and cervical SC [oxysterols] were quantified using high performance liquid chromatography mass spectrometry. Results were compared with respective α-TOH concentrations.ResultsSpinal cord [7-ketocholesterol], [7-hydroxycholesterol], and [7-keto-27-hydrocholesterol] were higher in eNAD/EDM horses whereas [24-ketocholesterol] was lower. No significant difference was found in CSF [F2 IsoP] and [F4 NP], serum [oxysterols] and CSF [oxysterols] between eNAD/EDM affected and unaffected horses. No correlation was found between [F2 IsoP], [F4 NP], or [oxysterols] and respective [α-TOH].Conclusions and clinical importanceIn the SC, targeted markers of cholesterol oxidation were significantly increased in horses with eNAD/EDM.

Published
2018

4. Horses affected by EPM have increased sCD14 compared to healthy horses

Author

Hay, Alayna N., Wagner, Bettina, Leeth, Caroline M., LeRoith, Tanya, Cecere, Thomas E., Lahmers, Kevin K., Andrews, Frank M., Werre, Stephen R., Johnson, Amy L., Clark, Carol K., Pusterla, Nicola, Reed, Stephen M., Lindsay, David S., Taylor, Sandra, Estell, Krista E., Furr, Martin, MacKay, Robert J., Del Piero, Fabio, and Witonsky, Sharon G.

Published
2021
Full Text
View/download PDF

5. Risk factors associated with development of colitis in horses post‐exploratory laparotomy.

Author

Givan, Stephanie A., Estell, Krista E., Martinez‐Lopez, Javier, Brown, James A., Wong, David M., and Werre, Stephen R.

Abstract

Copyright of Equine Veterinary Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

6. Sialoendoscopy as a treatment for an obstructed mandibular salivary duct in a horse.

Author

Prutton, James SW, Bonadio, Cecily, Vaughan, Betsy, Nieto, Jorge E, Harvey, Alison M, and Estell, Krista E

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Dental/Oral and Craniofacial Disease, Animals, Drainage, Endoscopy, Digestive System, Female, Foreign Bodies, Horse Diseases, Horses, Mandible, Radiography, Salivary Ducts, Salivary Gland Diseases, Veterinary sciences
Abstract

A 14-year-old Quarter Horse was examined for a draining tract of 8 months' duration on the right mandible that was non-responsive to antibiotic therapy and surgical therapy. Further investigation and subsequent treatment with sialoendoscopy and ultrasonography were performed to relieve an obstruction of plant awns in the mandibular salivary duct.

Published
2016

7. Persistence of Sarcocystis Neurona and Histologic Lesions in Horses with Equine Protozoal Myeloencephalitis (Epm)

Author

Helber, Lauren, primary, Wagner, Bettina, additional, Leeth, Caroline, additional, LeRoith, Tanya, additional, Cecere, Thomas, additional, Lahmers, Kevin, additional, Hay, Alayna, additional, Andrews, Frank M., additional, Werre, Stephen, additional, Johnson, Amy, additional, Clark, Carol, additional, Pusterla, Nicola, additional, Reed, Stephen, additional, Lindsay, David, additional, Taylor, Sandra, additional, Estell, Krista, additional, Furr, Martin, additional, Mackay, Robert, additional, Del Piero, Fabio, additional, Carossino, Mariano, additional, Pandaleon, Kacey, additional, Weatherford, Savannah, additional, Ramirez-Barrios, Roger, additional, Witonsky, Sharon, additional, and Zimmerman, Kurt, additional

Published
2024
Full Text
View/download PDF

9. Contributors

Author

Ainsworth, Dorothy M., primary, Aleman, Monica, additional, Angelos, John A., additional, Arroyo, Luis G., additional, Austin, Scott M., additional, Axon, Jane E., additional, Ballweber, Lora Rickard, additional, Bannasch, Danika L., additional, Barakzai, Safia Z., additional, Barrell, Emily A., additional, Barrington, George M., additional, Barton, Michelle H., additional, Bauman, Dale E., additional, Beasley, Erin McConachie, additional, Bedenice, Daniela, additional, Benson, Catherine J., additional, Benson, Dionne, additional, Betbeze, Caroline M., additional, Bickett-Weddle, Danelle A., additional, Blikslager, Anthony T., additional, A. Bohn, Andrea, additional, Bordin, Angela I., additional, Bowman, Dwight D., additional, Boyle, Ashley G., additional, Bozorgmanesh, Rana, additional, Bradford, Barry J., additional, Breuhaus, Babetta, additional, Brinsko, Steven P., additional, Browne, Nimet, additional, Buchanan, Ben, additional, Buczinski, Sébastien, additional, Burton, Alexandra J., additional, Burton, Erin N., additional, Byers, Stacey R., additional, Byrne, Barbara A., additional, Byrne, David P., additional, Callan, Robert J., additional, Cargile, Canaan Whitfield, additional, Carlson, Gary P., additional, Carr, Elizabeth A., additional, Carter, Renee T., additional, Casteel, Stan W., additional, Chaffin, M. Keith, additional, Chesen, Berkley, additional, Chigerwe, Munashe, additional, Christensen, Bruce W., additional, Chuck, Gemma, additional, Clothier, Kristin A., additional, Coetzee, Johann (Hans) F., additional, Coleman, Michelle C., additional, Collier, Robert J., additional, Cortese, Victor S., additional, Costa, Lais R., additional, Crossley, Beate M., additional, Davis, Jennifer L., additional, de Laat, Melody Anne, additional, Del Piero, Fabio, additional, Desrochers, André, additional, Dixon, Padraic Martin, additional, Dodd, Charles C., additional, Dominguez, Brandon J., additional, Dore, Vincent, additional, Duhamel, Gerald E., additional, Dunkel, Bettina, additional, Easley, Jack, additional, Ekenstedt, Kari J., additional, Ellis, John A., additional, Espinosa-Mur, Pablo, additional, Erskine, Ronald J., additional, E. Estell, Krista, additional, Evans, Timothy J., additional, Feary, Darien, additional, Fecteau, Gilles, additional, Fecteau, Marie-Eve, additional, Felippe, M. Julia B., additional, Fielding, C. Langdon, additional, Finno, Carrie J., additional, Fleming, Sherrill A., additional, Francoz, David, additional, Frank, Nicholas, additional, Fulton, Robert W., additional, Fultz, Lisa E., additional, Garland, Tam, additional, Garry, Franklyn, additional, Gemensky-Metzler, Anne J., additional, Gibbons, Philippa, additional, Giguère, Steeve, additional, Godden, Sandra, additional, Goff, Jesse Paul, additional, Gonda, Kathleen Casey, additional, Gonzalez, Liara M., additional, Grissett, Gretchen P., additional, Gunn, Alison A., additional, Gutierrez-Nibeyro, Santiago D., additional, Habasha, Faisal Ghazi, additional, Hall, Tiffany L., additional, Halland, Spring K., additional, Hallowell, Gayle D., additional, Hardy, Joanne, additional, Hart, Kelsey A., additional, Hartnack, Amanda K., additional, Heinrich, Daniel A., additional, Heller, Meera, additional, Herthel, Troy, additional, Hietala, Sharon K., additional, Hinchcliff, Kenneth W., additional, Hines, Melissa T., additional, House, John K., additional, Hovda, Lynn R., additional, Hughes, Angela M., additional, Hullinger, Pamela J., additional, Hund, Alexandra, additional, Hurley, David J., additional, James, Robert E., additional, John, Emily, additional, Johns, Jennifer L., additional, Johnson, Philip J., additional, Jones, Meredyth L., additional, Jones, Samuel L., additional, Jordan, Will C., additional, Judy, Carter E., additional, Katzman, Scott A., additional, Klein, Claudia, additional, Kreuder, Amanda J., additional, Lakritz, Jeffrey, additional, Landers, Benjamin, additional, Landolt, Gabriele A., additional, Lascola, Kara M., additional, Lassaline, Mary Elizabeth, additional, LeCouteur, Richard Andrew, additional, Lester, Guy D., additional, Leutenegger, Christian M., additional, Linton, Michelle, additional, Lofstedt, Jeanne, additional, Loinaz, Ricardo, additional, MacKay, Evelyn, additional, MacKay, Robert J., additional, Maclachlan, N. James, additional, Madigan, John E., additional, Magdesian, K. Gary, additional, Makhdoomi, Muhammad Muzafar, additional, Malone, John B., additional, Marsh, Peggy S., additional, Marshall, John F., additional, Martin, Krysta, additional, Mayo, Christie E., additional, Mazan, Melissa, additional, McArt, Jessica A., additional, McConnel, Craig, additional, McDowell, Karen, additional, McFarlane, Dianne, additional, McGill, Jodi L., additional, McGowan, Cathy, additional, McGuirk, Sheila M., additional, McNabb, Bret R., additional, Middleton, John R., additional, Millman, Suzanne T., additional, Morley, Paul S., additional, Mosier, Derek A., additional, Mostrom, Michelle, additional, Nagaraja, T.G., additional, Nichols, Sylvain, additional, Nielsen, Martin K., additional, Norman, Tracy E., additional, Norris, Jeffrey W., additional, Nydam, Daryl, additional, Oliver-Espinosa, Olimpo, additional, Parish, Steven M., additional, Pascoe, John R., additional, Payne, Michael, additional, Plummer, Caryn E., additional, Plummer, Paul J., additional, Poppenga, Robert H., additional, Pratt-Philips, Shannon E., additional, Puschner, Birgit, additional, Pusterla, Nicola, additional, Reef, Virginia B., additional, Renter, David G., additional, Reuss, Sarah M., additional, Reynolds, James P., additional, Romano, Sr., Juan E., additional, Ruegg, Pamela L., additional, Sager, Robert Bascom, additional, Sampson, Sarah N., additional, Sanchez, Chris, additional, Saulez, Montague N., additional, Schott, Harold C., additional, Sharkey, Leslie C., additional, Shearer, Jan K., additional, Slack, JoAnn, additional, Smith, Bradford P., additional, Smith, Geoffrey W., additional, Smith, Rachael L., additional, Spier, Sharon Jane, additional, Sponseller, Brett A., additional, Stämpfli, Henry, additional, St. Jean, Guy, additional, Stewart, Allison Jean, additional, Sweeney, Raymond W., additional, Swor, Tamara M., additional, Taylor, Jared D., additional, Tell, Lisa A., additional, Tennent-Brown, Brett, additional, Terra, Ronald L., additional, Théon, Alain P., additional, Tomlinson, Joy E., additional, Toribio, Ramiro E., additional, Troedsson, Mats H.T., additional, Tull, Travis M., additional, Uzal, Francisco A., additional, Valberg, Stephanie J., additional, Van Amstel, Sarel R., additional, Van Eps, Andrew W., additional, Van Metre, David C., additional, Varner, Dickson D., additional, Voyles, Meredith L., additional, Vygantas, Kristina R., additional, Walz, Paul, additional, Washburn, Kevin, additional, Waters, W. Ray, additional, Watkins, Jeffrey P., additional, Watson, Johanna L., additional, Watts, Ashlee E., additional, Weese, J. Scott, additional, White, Maurice Edward, additional, White, Stephen D., additional, Wilkins, Pamela A., additional, Williams, Jarred, additional, Williams, Kurt J., additional, Wilson, W. David, additional, Woodward, Elizabeth M., additional, Woolums, Amelia R., additional, and Wotman, Kathryn L., additional

Published
2020
Full Text
View/download PDF

10. Diseases of the Hematopoietic and Hemolymphatic Systems

Author

Watson, Johanna L., primary, Angelos, John A., additional, Clothier, Kristin A., additional, Estell, Krista E., additional, Madigan, John E., additional, Smith, Bradford P., additional, Spier, Sharon Jane, additional, Sponseller, Brett A., additional, Norris, Jeffrey W., additional, and Tabin, Fern, additional

Published
2020
Full Text
View/download PDF

13. Evaluation of a continuous glucose monitoring system in neonatal foals

Author

Wong, David, Malik, Caitlin, Dembek, Katarzyna, Estell, Krista, Marchitello, Megan, and Wilson, Katie

Subjects
critical care, sepsis, nutrition, point-of-care, human activities
Abstract

Background Monitoring blood glucose concentrations is common in critically ill neonatal foals, especially septic foals and those receiving naso-esophageal feedings or IV parenteral nutrition. Glucose typically is measured using a point-of-care (POC) glucometer but requires repeated restraint and blood collections, which may cause irritation at venipuncture sites and increased demands on nursing staff. Continuous glucose monitoring systems (CGMS) may provide an accurate alternative for monitoring blood glucose concentration. Objectives To determine the correlation and accuracy of a CGMS to monitor neonatal foals' blood glucose concentrations as compared to a POC glucometer and laboratory chemistry analysis (CHEM). Animals Samples from 4 healthy and 4 ill neonatal foals. Methods A CGMS was placed on each foal, and glucose measurements acquired from this device were compared to simultaneous measurements of blood glucose concentration using a POC glucometer and CHEM. Results Two-hundred matched glucose measurements were collected from 8 neonatal foals. The mean bias (95% limits of agreement) between CGMS and CHEM, CGMS and POC glucometer, and POC glucometer and CHEM was 3.97 mg/dL (-32.5 to 40.4), 18.2 mg/dL (-28.8 to 65.2), and 22.18 mg/dL (-9.3 to 53.67), respectively. The Pearson's correlation coefficient (r) was significantly correlated among all devices: GCMS and CHEM (r = 0.81), CGMS and POC glucometer (r = 0.77) and POC glucometer-CHEM (r = 0.92). Conclusions and Clinical Importance Within the blood glucose concentration ranges in this study (78-212 mg/dL), CGMS measurements were significantly correlated with CHEM, suggesting that it is an acceptable method to provide meaningful, immediate, and continuous glucose concentration measurements in neonatal foals while eliminating the need for repeated restraint and blood collection. Ace Construction Published version Ace Construction

Published
2021

14. Contributors

Author

Abutarbush, Sameeh M., primary, Aceto, Helen, additional, Affolter, Verena K., additional, Albanese, Valeria, additional, Aleman, Monica, additional, Allen, Kate, additional, Allen, Kent, additional, Alvarenga, Marco Antonio, additional, Andrews, Frank M., additional, Annear, Matthew, additional, Banse, Heidi, additional, Barrett, Elizabeth J., additional, Bauck, Anje G., additional, Beard, Laurie A., additional, Beard, Warren, additional, Belgrave, Rodney L., additional, Blanchard, Terry L., additional, Blott, Sarah, additional, Brandt, Sabine, additional, Branson, Keith R., additional, Brink, Palle, additional, Brockus, Charles W., additional, Brown, James A., additional, Buchanan, Benjamin R., additional, Buhl, Rikke, additional, Burba, Daniel J., additional, Burden, Faith, additional, Burns, Teresa A., additional, Camacho-Luna, Pilar, additional, Canisso, Igor F., additional, Carlson, Kelly L., additional, Carr, Elizabeth A., additional, Chapman, Hannah-Sophie, additional, Claes, Anthony, additional, Clayton, Hilary M., additional, Clode, Alison B., additional, Coleman, Michelle C., additional, Contino, Erin K., additional, Cook, R. Frank, additional, Cook, Vanessa L., additional, Corley, Kevin T., additional, Cullinane, Ann, additional, Coutinho da Silva, Marco A., additional, Dahlgren, Linda A., additional, Dart, Andrew J., additional, Davidson, Elizabeth J., additional, Davis, Elizabeth, additional, Dechant, Julie E., additional, Diaz-Méndez, Andrés, additional, Divers, Thomas J., additional, du Toit, Nicole, additional, Dunkel, Bettina, additional, Durham, Matthew G., additional, Dyson, Sue, additional, Eastman, Tim G., additional, Elton, Debra, additional, Epstein, Kira L., additional, Estell, Krista E., additional, Ewart, Susan L., additional, Ferris, Ryan A., additional, Fielding, C. Langdon, additional, Finan, Seán A., additional, Finno, Carrie J., additional, Fowlie, Jennifer, additional, Frank, Nicholas, additional, Franklin, Samantha H., additional, Frazer, Michele L., additional, Freeman, David E., additional, Furr, Martin, additional, Garrett, Katherine S., additional, Gilger, Brian C., additional, Gillis, Carol L., additional, Gimenez, Rebecca M., additional, Giuliano, Elizabeth A., additional, Goehring, Lutz S., additional, Goodrich, Laurie R., additional, Graves, Emily A., additional, Guthrie, Alan J., additional, Hackett, Eileen S., additional, Hahn, Caroline, additional, Hainisch, Edmund K., additional, Hanson, R. Reid, additional, Hart, Kelsey A., additional, Haussler, Kevin K., additional, Henninger, Rick W., additional, Hogan, Patricia M., additional, Hollis, Anna R., additional, Hurcombe, Samuel D.A., additional, Issel, Charles J., additional, Jesty, Sophy A., additional, Johnson, Amy L., additional, Johnson, Philip J., additional, Jokisalo, Jonna M., additional, Kamm, J. Lacy, additional, Katz, Lisa Michelle, additional, Knych, Heather K., additional, Labelle, Amber L., additional, Lacombe, Véronique A., additional, Landolt, Gabriele A., additional, Léguillette, Renaud, additional, Leutenegger, Christian M., additional, Lorch, Gwendolen, additional, Losinno, Luis, additional, Lugo, Joel, additional, Macpherson, Margo L., additional, Madigan, John E., additional, Magdesian, K. Gary, additional, Mair, Tim, additional, Mama, Khursheed R., additional, Marsella, Rosanna, additional, Mason, Clara Ann, additional, Matthews, Nora S., additional, McCarrel, Taralyn M., additional, McCluskey, Brian J., additional, McConnico, Rebecca S., additional, McCracken, Jeanette L., additional, McCue, Patrick M., additional, McGorum, Bruce C., additional, McGurrin, M. Kimberly J., additional, McKenzie, Harold C., additional, McKinnon, Angus O., additional, McNabb, Noelle T., additional, Meindel, Mandy J., additional, Mendes, Luiz Claudio Nogueira, additional, Millerick-May, Melissa L., additional, Morehead, James P., additional, Morresey, Peter R., additional, Morrison, Scott E., additional, Morton, Alison J., additional, Mowat, Freya M., additional, Murray, Rachel C., additional, Natalini, Claudio C., additional, Nelson, Brad B., additional, Neto, Carlos Ramires, additional, Newcombe, John R., additional, Newton, J. Richard, additional, Nielsen, Martin K., additional, O'Brien, Philippa, additional, O'Grady, Stephen E., additional, O'Neill, Henry D., additional, Oosterlinck, Maarten, additional, Paccamonti, Dale L., additional, Page, Allen E., additional, Papa, Frederico Ozanam, additional, Parkin, Tim D.H., additional, Parks, Andrew H., additional, Pease, Anthony P., additional, Peek, Simon F., additional, Pelzel-McCluskey, Angela M., additional, Perkins, Justin D., additional, Peroni, John F., additional, Peters, Duncan F., additional, Petersen, Annette, additional, Phillips, Jeffrey, additional, Plummer, Caryn E., additional, Powell, Sarah E., additional, Pozor, Malgorzata, additional, Prange, Timo, additional, Puschner, Birgit, additional, Pusterla, Nicola, additional, Pynn, Oliver D., additional, Ragle, Claude A., additional, Rashmir-Raven, Ann, additional, Reed, Stephen M., additional, Richter, Ruth-Anne, additional, Robinson, N. Edward, additional, Rombach, Nicole, additional, Ruggles, Alan J., additional, Runcan, Erin E., additional, Schott, Harold C., additional, Schroeder, Eric L., additional, Schumacher, John, additional, Schumacher, Stephen A., additional, Scoggin, Charles F., additional, Sellon, Debra C., additional, Sherlock, Ceri, additional, Sinclair, Charlotte, additional, Sinclair, Melissa, additional, Slovis, Nathan, additional, Soboll Hussey, Gisela, additional, Spier, Sharon J., additional, Sponseller, Beatrice T., additional, Sprayberry, Kim A., additional, Stack, Alice, additional, Stick, John, additional, Stover, Susan M., additional, Stratford, Claire H., additional, Stubbs, Narelle Colleen, additional, Taintor, Jennifer S., additional, Thiemann, Alexandra K., additional, Timoney, John F., additional, Toribio, Ramiro E., additional, Tranquille, Carolyne A., additional, Traub-Dargatz, Josie L., additional, Tulloch, Laura K., additional, Utter, Mary Lassaline, additional, van den Top, Gerald, additional, Varner, Dickson D., additional, Viel, Laurent, additional, von Schweinitz, Dietrich Graf, additional, Waldridge, Bryan M., additional, Walker, Vicki A., additional, Watts, Ashlee E., additional, Werner, Laura A., additional, Weyer, Camilla T., additional, White, Stephen D., additional, Wilkerson, Melinda J., additional, Wilkins, Pamela A., additional, Wilson, M. Eilidh, additional, Wilson, Pamela J., additional, Witte, Thomas H., additional, Wong, David M., additional, and Yiannikouris, Stavros, additional

Published
2015
Full Text
View/download PDF

21. Pharmacokinetics and pulmonary distribution of Draxxin® (tulathromycin) in healthy adult horses.

Author

Leventhal, Hannah R., McKenzie, Harold C., Estell, Krista, Council‐Troche, McAlister, and Davis, Jennifer L.

Subjects
ADULTS, PHARMACOKINETICS, HORSES, LIQUID chromatography-mass spectrometry, DRUG side effects, BIOAVAILABILITY
Abstract

The objective of this study was to determine the pharmacokinetics and tolerability of tulathromycin (Draxxin®; 2.5 mg/kg once) after intramuscular (IM), subcutaneous (SC), and slow intravenous (IV) administration to six adult horses. A three‐phase design and 4‐week washout period were used. Drug concentrations in blood and bronchoalveolar lavage (BAL) samples were determined by ultra‐performance liquid chromatography tandem mass spectrometry and pharmacokinetic parameters calculated using noncompartmental analysis. Following SC and IM administration, all horses exhibited sweating, discomfort, and periods of recumbency. As signs were more severe after SC administration this route was only used in 3/6 horses. Intravenous administration of tulathromycin was well tolerated in all horses. Mean bioavailability was 99.4% IM and 115% SC. Mean maximum plasma concentration was 645 ng/ml IM and 373 ng/ml SC. Mean half‐life was 59.8 h, 54.8 h, and 57.9 h for IV, IM, and SC administration, respectively. Mean clearance was 3.25 ml/kg/min, and mean volume of distribution was 16.8 L/kg following IV administration. Drug was detectable in plasma and BAL samples for 120 h following all routes; however, adverse effects may prevent IM use and SC use is not recommended. Tulathromycin may be a practical and affordable antimicrobial for use in adult equine patients. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

22. Immune‐mediated haemolytic anaemia and thrombocytopenia in 25 adult equids: 1997‐2016.

Author

Easton‐Jones, Charlotte A., Estell, Krista E., and Magdesian, K. Gary

Abstract

Background: Information concerning clinical presentation, conditions associated with immune‐mediated haemolytic anaemia (IMHA) and thrombocytopenia (IMTP) and outcome in equids is lacking. Previous case reports suggest that immune‐mediated disease and neoplasia are associated. Objectives: Characterise the clinical presentation, clinicopathologic data, underlying conditions, treatment and outcome of IMHA and IMTP cases in equids. We hypothesise that IMHA with concurrent thrombocytopenia occurs more often than IMHA or IMTP alone, and that neoplasia is commonly associated with these immune diseases and cases frequently have a poor prognosis. Study design: Retrospective case‐control study. Methods: Medical records were reviewed from 1997 to 2016. Twenty‐five equids were diagnosed with IMHA, IMTP or IMHA with thrombocytopenia by Coombs test or flow cytometry. Controls were equids presented for nonimmune‐mediated disease immediately prior to and after study animals. Fisher's exact test was used to compare between groups for categorical variables (P <.05). Results reported as odds ratios (OR) and 95% confidence intervals (CI). Unpaired t test and Mann‐Whitney test were used to compare between groups for continuous variables (P <.05). Results: Neoplasia incidence was significantly higher in the study population (28%) versus controls (8%) (P =.04). Equids with primary disease were more likely to survive to discharge than equids with secondary disease (8/9 vs 7/16; P =.03; OR = 13.3; 95% CI: 1.3‐134.7). Survivors had a significantly lower blood urea nitrogen (BUN) than those that died or were subjected to euthanasia (survivors, 6.1 ± 2.5 mmol/L vs nonsurvivors, 9.9 ± 3.1 mmol/L P =.003). The odds of short‐term mortality were higher in horses presenting with increased BUN (OR = 19.5; 95% CI, 1.8‐214.1; P =.009). Main limitations: Retrospective nature of the study, small case numbers and limited long‐term follow‐up. Conclusions: Primary IMHA/IMTP cases have a reasonable prognosis and warrant treatment. Secondary cases have a poor prognosis, and are frequently associated with cancer. BUN may have utility as a prognostic indicator for IMHA/IMTP cases. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

25. Prospective pre- and post-race evaluation of biochemical, electrophysiologic, and echocardiographic indices in 30 racing thoroughbred horses that received furosemide

Author

Gunther-Harrington, Catherine T., Arthur, Rick, Estell, Krista, Martinez Lopez, Beatriz, Sinnott, Alexandra, Ontiveros, Eric, Varga, Anita, Stern, Joshua A., Gunther-Harrington, Catherine T., Arthur, Rick, Estell, Krista, Martinez Lopez, Beatriz, Sinnott, Alexandra, Ontiveros, Eric, Varga, Anita, and Stern, Joshua A.

Abstract

Background Exercise induced cardiac fatigue (EICF) and cardiac dysrhythmias are well described conditions identified in high-level human athletes that increase in frequency with intensity and duration of exercise. Identification of these conditions requires an understanding of normal pre- and post-race cardiac assessment values. The objectives of this study were to (1) characterize selected indices of cardiac function, electrophysiologic parameters, and biochemical markers of heart dysfunction prior to and immediately after high level racing in Thoroughbred horses receiving furosemide; and (2) create pre- and post-race reference values in order to make recommendations on possible screening practices for this population in the future. Results Thirty Thoroughbred horses were enrolled in the study with an age range of 3–6 years. All horses received furosemide prior to racing. Physical exams, ECGs, and echocardiograms were performed prior to racing (T0) and within 30–60 min following the race (T1). Blood samples were obtained at T0, T1, 4 h post-race (T4) and 24 h after the race (T24). Electrolytes, hematocrit, cardiac troponin I, and partial pressure CO2 values were obtained at all time points. Heart rate was significantly increased post-race compared to baseline value with a median difference of 49 bpm, 95% CI [31,58],(P < 0.0001). No dysrhythmias were noted during ECG assessment. Following the race, an increase in number of horses demonstrating regurgitation through the aorta and AV valves was noted. Systolic function measured by fractional shortening increased significantly with a mean difference of 7.9%, 95% CI [4.8, 10.9], (P < 0.0001). Cardiac troponin I was not different at pre- and immediately post-race time points, but was significantly increased at T4 (P < 0.001). Troponin returned to baseline value by T24. Conclusions This study utilized a before and after study design where each horse served as its own control, as such the possible effect of regression to t

Published
2018
Full Text
View/download PDF

26. Sialoendoscopy as a treatment for an obstructed mandibular salivary duct in a horse

Author

Prutton, James S.W., Bonadio, Cecily, Vaughan, Betsy, Nieto, Jorge E., Harvey, Alison M., and Estell, Krista E.

Subjects
Scientific, Salivary Gland Diseases, Endoscopy, Mandible, Foreign Bodies, Radiography, Salivary Ducts, Animals, Drainage, Horse Diseases, Female, Endoscopy, Digestive System, Horses, Veterinary Sciences, Dental/Oral and Craniofacial Disease, Digestive System
Abstract

A 14-year-old Quarter Horse was examined for a draining tract of 8 months' duration on the right mandible that was non-responsive to antibiotic therapy and surgical therapy. Further investigation and subsequent treatment with sialoendoscopy and ultrasonography were performed to relieve an obstruction of plant awns in the mandibular salivary duct.

Published
2016

29. The prevalence of temporal bone fractures is high in horses with severe temporohyoid osteoarthropathy.

Author

Tanner, Jacqui, Spriet, Mathieu, Espinosa‐Mur, Pablo, Estell, Krista E., and Aleman, Monica

Abstract

Temporohyoid osteoarthropathy is a well‐recognized cause of equine neurologic disease. Temporal bone fractures associated with temporohyoid osteoarthropathy have been recognized with CT, however, little information is available regarding these fractures. The aims of this retrospective analytical study were to assess the prevalence of these fractures and to describe the specific configurations and associated imaging and clinical features. Fracture of the temporal bone was identified with CT in 16 of 39 included horses. All fractures were unilateral, minimally displaced and extended through the temporal bone in a rostrodorsal to caudoventral orientation. Two fracture configurations were identified: in nine cases, the fracture extended the full width of the petrous pyramid into the cranial vault and in seven cases, the fracture only extended through the lateral part of the petrous temporal bone, not involving the cranial vault. Fusion of the temporohyoid joint was present in 13 of the 16 fracture cases. Quarter Horses were over‐represented in the fractured population (14/16). All horses with fractures had ipsilateral neurologic deficits. Patient outcomes were not significantly different between temporohyoid osteoarthropathy horses with and without temporal bone fractures (P = 0.68). However, six of the nine patients with cranial vault involvement did not return to their previous use. Findings support previous studies indicating that temporal bones should be carefully assessed for concurrent fractures when temporohyoid osteoarthropathy is identified in CT images, especially when there is fusion of the temporohyoid joint. An improved awareness of specific fracture configurations will help with detection of these fractures. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

30. Atrial Fibrillation in Eight New World Camelids

Author

Bozorgmanesh, R., Magdesian, K. G., Estell, Krista, Stern, J. A., Swain, E. A., Griffiths, L. G., Bozorgmanesh, R., Magdesian, K. G., Estell, Krista, Stern, J. A., Swain, E. A., and Griffiths, L. G.

Abstract

BACKGROUND: There is limited information on the incidence of clinical signs, concurrent illness and treatment options for atrial fibrillation (AF) in New World Camelids (NWC). OBJECTIVE: Describe clinical signs and outcome of AF in NWC. ANIMALS: Eight New World Camelids admitted with AF. METHODS: A retrospective observational study of camelids diagnosed with AF based on characteristic findings on electrocardiogram (ECG). RESULTS: All animals had an irregularly irregular heart rhythm detected on physical examination and 4 cases had obtunded mentation on admission. Three camelids were diagnosed with AF secondary to oleander intoxication, 3 animals had underlying cardiovascular disease, 1 was diagnosed with lone AF and 1 had AF diagnosed on examination for a urethral obstruction. Five of eight animals survived to discharge and nonsurvivors consisted of animals which died or were euthanized as a result of cardiovascular disease (2/8) or extra-cardiac disease unrelated to the AF (1/8). CONCLUSIONS AND CLINICAL IMPORTANCE: Atrial fibrillation occurs in NWC in association with cardiovascular disease, extra-cardiac disease or as lone AF. Amiodarone and transthoracic cardioversion were attempted in one llama with lone AF, but were unsuccessful. Atrial fibrillation was recorded in 0.1% of admissions.

Published
2016
Full Text
View/download PDF

31. Pneumonia Caused by Klebsiella spp. in 46 Horses

Author

Estell, Krista, Young, A., Kozikowski, T., Swain, E. A., Byrne, B. A., Reilly, Christopher M., Kass, P. H., Aleman, M., Estell, Krista, Young, A., Kozikowski, T., Swain, E. A., Byrne, B. A., Reilly, Christopher M., Kass, P. H., and Aleman, M.

Abstract

BACKGROUND: Klebsiella spp. are implicated as a common cause of bacterial pneumonia in horses, but few reports describe clinical presentation and disease progression. HYPOTHESIS/OBJECTIVES: To describe the signalment, clinicopathologic data, radiographic and ultrasonographic findings, antimicrobial susceptibility, outcome, and pathologic lesions associated with Klebsiella spp. pneumonia in horses. ANIMALS: Forty-six horses from which Klebsiella spp. was isolated from the lower respiratory tract. METHODS: Retrospective study. Medical records from 1993 to 2013 at the William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis were reviewed. Exact logistic regression was performed to determine if any variables were associated with survival to hospital discharge. RESULTS: Survival in horses <1 year old was 73%. Overall survival in adults was 63%. For adults in which Klebsiella pneumoniae was the primary isolate, survival was 52%. Mechanical ventilation preceded development of pneumonia in 11 horses. Complications occurred in 25/46 horses, with thrombophlebitis and laminitis occurring most frequently. Multi-drug resistance was found in 47% of bacterial isolates. Variables that significantly impacted survival included hemorrhagic nasal discharge, laminitis, and thoracic radiographs with a sharp demarcation between marked caudal pulmonary alveolar infiltration and more normal-appearing caudodorsal lung. CONCLUSIONS AND CLINICAL IMPORTANCE: Klebsiella spp. should be considered as a differential diagnosis for horses presenting with hemorrhagic pneumonia and for horses developing pneumonia after mechanical ventilation. Multi-drug resistance is common. Prognosis for survival generally is fair, but is guarded for adult horses in which K. pneumoniae is isolated as the primary organism.

Published
2016

32. Blood and Cerebrospinal Fluid α-Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy

Author

Finno, C. J., Estell, Krista, Katzman, S., Winfield, L., Rendahl, A., Textor, J., Bannasch, D. L., Puschner, B., Finno, C. J., Estell, Krista, Katzman, S., Winfield, L., Rendahl, A., Textor, J., Bannasch, D. L., and Puschner, B.

Abstract

BACKGROUND: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet. OBJECTIVE: Intramuscular α-TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) α-TP in healthy foals. Serum and CSF α-TP, but not Se, would be significantly decreased in NAD/EDM-affected foals during first year of life. ANIMALS: Fourteen Quarter horse foals; 10 healthy foals supplemented with 0.02 mL/kg injectable α-TP and Se (n = 5) or saline (n = 5) at 4 days of age and 4 unsupplemented NAD/EDM-affected foals. METHODS: Complete neurologic examinations were performed, blood and CSF were collected before (4 days of age) and after supplementation at 10, 30, 60, 120, 180, 240, and 360 days of age. Additional blood collections occurred at 90, 150, 210, and 300 days. At 540 days, NAD/EDM-affected foals and 1 unsupplemented healthy foal were euthanized and necropsies performed. RESULTS: Significant decreases in blood, CSF α-TP and Se found in the first year of life in all foals, with most significant changes in serum α-TP from 4-150 days. Dam α-TP and Se significantly influenced blood concentrations in foals. Injection of α-TP and Se did not significantly increase CSF Se, blood or CSF α-TP in healthy foals. NAD/EDM-affected foals had significantly lower CSF α-TP through 120 days. CONCLUSIONS AND CLINICAL IMPORTANCE: Injection of α-TP and Se at 4 days of age does not significantly increase blood or CSF α-TP. Despite all 14 foals remaining deficient in α-TP, only the 4 genetically predisposed foals developed NAD/EDM.

Published
2015
Full Text
View/download PDF

33. Pharmacokinetics and pulmonary distribution of Draxxin® (tulathromycin) in healthy adult horses

Author

Leventhal, Hannah Rani, Biomedical and Veterinary Sciences, Davis, Jennifer Lynn, Wilson, Katherine E., Estell, Krista Elise, Byron, Christopher R., and McKenzie, Harold C.

Subjects
antibacterial, macrolides, adverse drug reaction, equine
Abstract

The objective of this study was to determine the pharmacokinetics and tolerance of tulathromycin (Draxxin®; 2.5 mg/kg once) after intramuscular (IM), subcutaneous (SC), and slow intravenous (IV) administration to six adult horses. A three-phase design and 4-week washout period were used. Drug concentrations in blood and bronchoalveolar lavage (BAL) samples were determined by ultra-performance liquid chromatography tandem mass spectrometry and pharmacokinetic parameters calculated using noncompartmental analysis. Following SC and IM administration, all horses exhibited sweating, discomfort, and periods of recumbency. As signs were more severe after SC administration this route was only used in 3/6 horses. Intravenous administration of tulathromycin was well tolerated in all horses. Mean bioavailability was 99.4% IM and 115% SC. Mean maximum plasma concentration was 645 ng/ml IM and 373 ng/ ml SC. Mean half-life was 59.8 h, 54.8 h, and 57.9 h for IV, IM, and SC administration, respectively. Mean clearance was 3.25 ml/kg/min, and mean volume of distribution was 16.8 L/kg following IV administration. Drug was detectable in plasma and BAL samples for 120 h following all routes; however, adverse effects may prevent IM use and SC use is not recommended. Tulathromycin may be a practical and affordable antibacterial for use in adult equine patients. Master of Science In human and veterinary medicine, antibacterial drugs are a mainstay of treatment. Antibacterials have been used for almost 100 years to prevent microbial organism infection, and as a treatment once there is an established infection. Although there are multiple "classes" of antibacterials that have different spectrums of activity and mechanisms of action, antibacterial resistance has become increasingly prevalent over time. The increasing rate of antimicrobial resistance has led to recommendations that medical practitioners be more judicious in the use of these drugs and to prescribe antibacterials to patients only when necessary. In equine medicine, once an antibacterial is deemed necessary, there are additional considerations, including administration method, frequency of administration, and availability and cost of antibacterial drugs. Tulathromycin, a long-acting semi-synthetic macrolide, is an antibacterial that is approved for use in cattle and swine and may have utility for equine patients for a variety of conditions. This study in healthy adult horses demonstrated that tulathromycin was detectable in plasma and the respiratory tract for up to 5 days after single dose administration. Thus, tulathromycin may be a practical and affordable antibacterial for use in equine patients.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results