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1. Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

Author

Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Krohn, Kristopher J, Daoud, Farah, Chew, Adrienne, Kassebaum, Nicholas J, Colombara, Danny, Cornaby, Leslie, Ehrenkranz, Rebecca, Foreman, Kyle J, Fraser, Maya, Frostad, Joseph, Kemmer, Laura, Kulikoff, Xie Rachel, Kutz, Michael, Kyu, Hmwe H, Liu, Patrick, Mikesell, Joseph, Nguyen, Grant, Rao, Puja C, Silpakit, Naris, Sligar, Amber, Smith, Alison, Stanaway, Jeffrey D, Arnlov, Johan, Abate, Kalkidan Hassen, Kiadaliri, Aliasghar Ahmad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Alraddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Anber, Nahla, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Artaman, Al, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Azzopardi, Peter, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Bedi, Neeraj, Beghi, Ettore, Bennett, Derrick A, Bhutta, Zulfiqar A, Bisanzio, Donal, Castaneda-Orjuela, Carlos A, Estanislao Castro, Ruben, Danawi, Hadi, Deribe, Kebede, Deribew, Amare, Jarlais, Don C Des, deVeber, Gabrielle A, Dey, Subhojit, Dharmaratne, Samath D, Djalalinia, Shirin, Do, Huyen Phuc, Esteghamati, Alireza, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Giussani, Giorgia, Gona, Philimon N, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Hoy, Damian G, Hu, Guoqing, John, Denny, Jonas, Jost B, Karimi, Seyed M, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Kim, Daniel, Kim, Yun Jin, Kinfu, Yohannes, Larson, Heidi J, Latif, Asma Abdul, Leasher, Janet L, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, Memish, Ziad A, Mendoza, Walter, Mezgebe, Haftay Berhane, Miller, Ted R, Monasta, Lorenzo, Nguyen, Quyen Le, Obermeyer, Carla Makhlouf, Ortiz, Alberto, Papachristou, Christina, Park, Eun-Kee, Pereira, Claudia C, Petzold, Max, Pereira, David M, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Rezai, Mohammad Sadegh, Ronfani, Luca, Roshandel, Gholamreza, Ruhago, George Mugambage, Safdarian, Mahdi, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Sartorius, Benn, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Setegn, Tesfaye, Shaheen, Amira, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shiri, Rahman, Skirbekk, Vegard, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Thakur, Arabia JS, Thomson, Alan J, Tran, Bach Xuan, Truelsen, Thomas, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vasankari, Tommi, Vlassov, Vasiliy Victorovich, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Yaghoubi, Mohsen, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Wang, Haidong, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Department of Public Health, Clinicum, and University of Helsinki

Subjects
Male, PNEUMONIA, Pediatrics, Health (social science), Poison control, 030204 cardiovascular system & hematology, Infant mortality, Global Health, Global Burden of Disease, 0302 clinical medicine, Neonatal, Global health, LIFE EXPECTANCY, 030212 general & internal medicine, health care economics and organizations, Mediterranean Region, Child Health, Burden of disease, 3142 Public health care science, environmental and occupational health, 3. Good health, UPDATED SYSTEMATIC ANALYSIS, 1117 Public Health And Health Services, Child, Preschool, Female, Original Article, Public Health, CHILD-MORTALITY, INTERVENTIONS, COUNTRIES, Child mortality, medicine.medical_specialty, INTEGRATED APPROACH, Eastern Mediterranean Region, 03 medical and health sciences, Middle East, Neonatal mortality, Environmental health, Injury prevention, medicine, Humans, PROGRESS, Perinatal Mortality, METAANALYSIS, business.industry, Public Health, Environmental and Occupational Health, Infant, Newborn, Klinisk medicin, Infant, DIARRHEA, mortality, Eastern mediterranean, Life expectancy, Morbidity, Clinical Medicine, business
Abstract

Objectives Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. Methods We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. Results In 2015, 755,844 (95% uncertainty interval (UI) 712,064–801,565) children under 5 died in the EMR. In the early neonatal category, deaths in the EMR decreased by 22.4%, compared to 42.4% globally. The rate of years of life lost per 100,000 population under 5 decreased 54.38% from 177,537 (173,812–181,463) in 1990 to 80,985 (76,308–85,876) in 2015; the rate of years lived with disability decreased by 0.57% in the EMR compared to 9.97% globally. Conclusions Our findings call for accelerated action to decrease child morbidity and mortality in the EMR. Governments and organizations should coordinate efforts to address this burden. Political commitment is needed to ensure that child health receives the resources needed to end preventable deaths. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-0998-x) contains supplementary material, which is available to authorized users.

Published
2018

2. Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author

Mokdad, Ali H, Tehrani-Banihashemi, Arash, Moradi-Lakeh, Maziar, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Afshin, Ashkan, Collison, Michael, Daoud, Farah, Krohn, Kristopher J, Chew, Adrienne, Cornaby, Leslie, Foreman, Kyle J, Frostad, Joseph, Kassebaum, Nicholas J, Kemmer, Laura, Kutz, Michael, Liu, Patrick, Mirarefin, Mojde, Nguyen, Grant, Wang, Haidong, Zipkin, Ben, Abajobir, Amanuel Alemu, Abouzeid, Marian, Abu-Rmeileh, Niveen ME, Kiadaliri, Aliasghar Ahmad, Ahmed, Muktar Beshir, Aksut, Baran, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Anber, Nahla, Anwari, Palwasha, Arnlov, Johan, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mehari, Awasthi, Ashish, Baernighausen, Till, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Bedi, Neeraj, Bennett, Derrick A, Berhe, Derbew Fikadu, Biadgilign, Sibhatu, Butt, Zahid A, Carapetis, Jonathan R, Estanislao Castro, Ruben, Chitheer, Abdulaal A, Davletov, Kairat, Dharmaratne, Samath D, Djalalinia, Shirin, Do, Huyen Phuc, Dubey, Manisha, Ebrahimi, Hedyeh, Eshrati, Babak, Esteghamati, Alireza, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Solomon Weldemariam, Gebrehiwot, Tsegaye Tewelde, Gillum, Richard F, Gona, Philimon N, Gupta, Rajeev, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Hsairi, Mohamed, Jee, Sun Ha, Jonas, Jost B, Karimkhani, Chante, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Kim, Daniel, Lal, Dharmesh Kumar, Larson, Heidi J, Latif, Asma Abdul, Linn, Shai, Lotufo, Paulo A, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Meier, Toni, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mensah, George A, Meretoja, Atte, Miller, Ted R, Mirrakhimov, Erkin M, Mohammed, Shafiu, Nguyen, Quyen Le, Nong, Vuong Minh, Pearson-Stuttard, Jonathan, Pishgar, Farhad, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Roba, Kedir Teji, Roshandel, Gholamreza, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Milicevic, Milena M Santric, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Santos Silva, Diego Augusto, Singh, Jasvinder A, Sobaih, Badr HA, Stroumpoulis, Konstantinos, Abdulkader, Rizwan Suliankatchi, Szoeke, Cassandra EI, Temsah, Mohamad-Hani, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vasankari, Tommi, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wakayo, Tolassa, Weintraub, Robert G, Wessly, Priscilla R, Wijeratne, Tissa, Wolfe, Charles DA, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yano, Yuichiro, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Roth, Gregory A, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Tehrani-Banihashemi, A, Moradi-Lakeh, M, El Bcheraoui, C, Ahmed, MB, Mokdad, AH, GBD 2015 Eastern Mediterranean Region Cardiovascular Disease Collaborators, Department of Neurosciences, Neurologian yksikkö, Clinicum, and HUS Neurocenter

Subjects
AFFORDABILITY, PERSONAL HEALTH-CARE, Health (social science), Heart disease, Eastern Mediterranean region, 030204 cardiovascular system & hematology, burden of disease, Global Health, Body Mass Index, Global Burden of Disease, Cardiovascular disease, Burden of disease, Eastern Mediterranean Region, 0302 clinical medicine, SAUDI-ARABIA, Risk Factors, cardiovascular disease, Global health, 030212 general & internal medicine, PREDICTORS, 2. Zero hunger, Middle East, Mediterranean Region, Middle Aged, 3142 Public health care science, environmental and occupational health, 3. Good health, MIDDLE-INCOME, Cholesterol, 1117 Public Health And Health Services, Cardiovascular Diseases, MEDICINES, Hypertension, Original Article, Female, Quality-Adjusted Life Years, Public Health, Adult, 03 medical and health sciences, Environmental health, medicine, Humans, INCOME COUNTRIES, ARÁBIA SAUDITA, business.industry, MORTALITY, AVAILABILITY, Public Health, Environmental and Occupational Health, Klinisk medicin, Middle income, medicine.disease, Quality-adjusted life year, Eastern mediterranean, Clinical Medicine, business, Body mass index
Abstract

Objectives To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990–2015. Methods We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR. Results A total of 1.4 million CVD deaths (95% UI: 1.3–1.5) occurred in 2015 in the EMR, with the highest number of deaths in Pakistan (465,116) and the lowest number of deaths in Qatar (723). The age-standardized DALY rate per 100,000 decreased from 10,080 in 1990 to 8606 in 2015 (14.6% decrease). Afghanistan had the highest age-standardized DALY rate of CVD in both 1990 and 2015. Kuwait and Qatar had the lowest age-standardized DALY rates of CVD in 1990 and 2015, respectively. High blood pressure, high total cholesterol, and high body mass index were the leading risk factors for CVD. Conclusions The age-standardized DALY rates in the EMR are considerably higher than the global average. These findings call for a comprehensive approach to prevent and control the burden of CVD in the region. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1012-3) contains supplementary material, which is available to authorized users.

Published
2018

3. Evolution and patterns of global health financing 1995-2014 : development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries

Author

Dieleman, Joseph, Campbell, Madeline, Chapin, Abigail, Eldrenkamp, Erika, Fan, Victoria Y., Haakenstad, Annie, Kates, Jennifer, Liu, Yingying, Matyasz, Taylor, Micah, Angela, Reynolds, Alex, Sadat, Nafis, Schneider, Matthew T., Sorensen, Reed, Evans, Tim, Evans, David, Kurowski, Christoph, Tandon, Ajay, Abbas, Kaja M., Abera, Semaw Ferede, Kiadaliri, Aliasghar Ahmad, Ahmed, Kedir Yimam, Ahmed, Muktar Beshir, Alam, Khurshid, Alizadeh-Navaei, Reza, Alkerwi, Ala'a, Amini, Erfan, Ammar, Walid, Amrock, Stephen Marc, Antonio, Carl Abelardo T., Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Barac, Aleksandra, Alberto Bernal, Oscar, Beyene, Addisu Shunu, Beyene, Tariku Jibat, Birungi, Charles, Bizuayehu, Habtamu Mellie, Breitborde, Nicholas J. K., Cahuana-Hurtado, Lucero, Estanislao Castro, Ruben, Catalia-Lopez, Ferran, Dalal, Koustuv, Dandona, Lalit, Dandona, Rakhi, de Jager, Pieter, Dharmaratne, Samath D., Dubey, Manisha, Meretoja, Atte, Global Burden Dis Hlth Financing, Department of Neurosciences, Neurologian yksikkö, Clinicum, and HUS Neurocenter

Subjects
AFRICA, PLASMODIUM-FALCIPARUM, 3121 General medicine, internal medicine and other clinical medicine, SYSTEMATIC ANALYSIS, PAYMENTS, INSURANCE, LIFE EXPECTANCY, CARE, BURDEN, EXPENDITURE, TRANSITION
Abstract

Background An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development. We also identify countries that deviate from the trends. Methods We estimated national health spending by type of care and by source, including development assistance for health, based on a diverse set of data including programme reports, budget data, national estimates, and 964 National Health Accounts. These data represent health spending for 184 countries from 1995 through 2014. We converted these data into a common inflation-adjusted and purchasing power-adjusted currency, and used non-linear regression methods to model the relationship between health financing, time, and economic development. Findings Between 1995 and 2014, economic development was positively associated with total health spending and a shift away from a reliance on development assistance and out-of-pocket (OOP) towards government spending. The largest absolute increase in spending was in high-income countries, which increased to purchasing power-adjusted $5221 per capita based on an annual growth rate of 3.0%. The largest health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, respectively. Spending in low-income countries grew nearly as fast, at 4.6%, and health spending increased from $51 to $120 per capita. In 2014, 59.2% of all health spending was financed by the government, although in low-income and lower-middle-income countries, 29.1% and 58.0% of spending was OOP spending and 35.7% and 3.0% of spending was development assistance. Recent growth in development assistance for health has been tepid; between 2010 and 2016, it grew annually at 1.8%, and reached US$37.6 billion in 2016. Nonetheless, there is a great deal of variation revolving around these averages. 29 countries spend at least 50% more than expected per capita, based on their level of economic development alone, whereas 11 countries spend less than 50% their expected amount. Interpretation Health spending remains disparate, with low-income and lower-middle-income countries increasing spending in absolute terms the least, and relying heavily on OOP spending and development assistance. Moreover, tremendous variation shows that neither time nor economic development guarantee adequate prepaid health resources, which are vital for the pursuit of universal health coverage.

Published
2017

4. Future and potential spending on health 2015-40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries

Author

Dieleman, Joseph L., Campbell, Madeline, Chapin, Abigail, Eldrenkamp, Erika, Fan, Victoria Y., Haakenstad, Annie, Kates, Jennifer, Li, Zhiyin, Matyasz, Taylor, Micah, Angela, Reynolds, Alex, Sadat, Nafis, Schneider, Matthew T., Sorensen, Reed, Abbas, Kaja M., Abera, Semaw Ferede, Kiadaliri, Aliasghar Ahmad, Ahmed, Muktar Beshir, Alam, Khurshid, Alizadeh-Navaei, Reza, Alkerwi, Ala'a, Amini, Erfan, Ammar, Walid, Antonio, Carl Abelardo T., Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Barac, Aleksandra, Berheto, Tezera Moshago, Beyene, Addisu Shunu, Beyene, Tariku Jibat, Birungi, Charles, Bizuayehu, Habtamu Mellie, Breitborde, Nicholas J. K., Cahuana-Hurtado, Lucero, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Dalal, Koustuv, Dandona, Lalit, Dandona, Rakhi, Dharmaratne, Samath D., Dubey, Manisha, Faro, Ande, Feigl, Andrea B., Fischer, Florian, Fitchett, Joseph R. Anderson, Foigt, Nataliya, Giref, Ababi Zergaw, Gupta, Rahul, Hamidi, Samer, Harb, Hilda L., Hay, Simon I., Hendrie, Delia, Horino, Masako, Jurisson, Mikk, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, John, Denny, Jonas, Jost B., Karimi, Seyed M., Khang, Young-Ho, Khubchandani, Jagdish, Kim, Yun Jin, Kinge, Jonas M., Krohn, Kristopher J., Kumar, G. Anil, Leung, Ricky, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Meretoja, Atte, Miller, Ted R., Mirrakhimov, Erkin M., Mohammed, Shafiu, Molla, Gedefaw, Nangia, Vinay, Olgiati, Stefano, Owolabi, Mayowa O., Patel, Tejas, Caicedo, Angel J. Paternina, Pereira, David M., Perelman, Julian, Polinder, Suzanne, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Ram, Usha, Ranabhat, Chhabi Lal, Roba, Hirbo Shore, Savic, Miloje, Sepanlou, Sadaf G., Te Ao, Braden J., Tesema, Azeb Gebresilassie, Thomson, Alan J., Tobe-Gai, Ruoyan, Topor-Madry, Roman, Undurraga, Eduardo A., Vargas, Veronica, Vasankari, Tommi, Violante, Francesco S., Wijeratne, Tissa, Xu, Gelin, Yonemoto, Naohiro, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Murray, Christopher J. L., Department of Neurosciences, Neurologian yksikkö, Clinicum, and HUS Neurocenter

Subjects
INCOME, Science & Technology, Medicine, General & Internal, General & Internal Medicine, DEMAND, 3121 General medicine, internal medicine and other clinical medicine, PAYMENTS, INSURANCE, 11 Medical And Health Sciences, Life Sciences & Biomedicine, CHOICE, MEDICAL-CARE, POVERTY
Abstract

Background The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings We estimated that global spending on health will increase from US$9.21 trillion in 2014 to $24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at $154 (UI 133-181) per capita in 2030 and $195 (157-258) per capita in 2040. Increases in national health spending to reach the level of the countries who spend the most on health, relative to their level of economic development, would mean $321 (157-258) per capita was available for health in 2040 in low-income countries. Interpretation Health spending is associated with economic development but past trends and relationships suggest that spending will remain variable, and low in some low-resource settings. Policy change could lead to increased health spending, although for the poorest countries external support might remain essential.

Published
2017

5. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015

Author

Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. Ross, Bhutta, Zulficiar A., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Cercy, Kelly, Charlson, Fiona J., Cohen, Aaron J., Dandona, Lalit, Estep, Kara, Ferrari, Alize J., Frostad, Joseph J., Fullman, Nancy, Gething, Peter W., Godwin, William W., Griswold, Max, Kinfu, Yohannes, Kyu, Hmwe H., Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Liu, Patrick Y., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Neal, Bruce, Reitsma, Marissa B., Roth, Gregory A., Salomon, Joshua A., Sur, Patrick J., Vos, Theo, Wagner, Joseph A., Wang, Haidong, Zhao, Yi, Zhou, Maigeng, Aasvang, Gunn Marit, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abdulle, Abdishakur M., Abera, Semaw Ferede, Abraham, Biju, Abu-Raddad, Laith J., Abyu, Gebre Yitayih, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Ademi, Zanfina, Adou, Arsene Kouablan, Adsuar, Jose C., Agardh, Emilie Elisabet, Agarwal, Arnav, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ajala, Oluremi N., Akinyemiju, Tomi F., Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alsharif, Ubai, Altirkawi, Khalid A., Alvarez Martin, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwar, Palwasha, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Barac, Aleksandra, Barber, Ryan M., Barker-Collo, Suzanne L., Baernighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Basu, Sanjay, Bans, Carolina, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Boris, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D., Borschmann, Rohan, Boufous, Soufiane, Bourne, Rupert R. A., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Broday, David M., Brugha, Traolach S., Brunekreef, Bert, Butt, Zahid A., Cahill, Leah E., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cardenas, Rosario, Carpenter, David, Casey, Daniel C., Castaneda-Oquela, Carlos A., Castillo Rivas, Jacqueline, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Coates, Matthew M., Colquhoun, Samantha M., Cooper, Leslie Trumbull, Cooperrider, Kimberly, Cornaby, Leslie, Cortinovis, Monica, Crump, John A., Cuevas-Nasu, Lucia, Damasceno, Albertino, Dandona, Rakhi, Darby, Sarah C., Dargan, Paul I., das Neves, Jose, Davis, Adrian C., Davletov, Kairat, Filipa de Castro, E., De la Cruz-Gongora, Vanessa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribew, Amare, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Tome, Cesar, Dicker, Daniel, Ding, Eric L., Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. Gerry R., Franklin, Richard C., Fuerst, Thomas, Futran, Neal D., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Goenka, Shifalika, Carmen Gomez-Cabrera, Mari, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Gugnani, Harish Chander, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gutierrez, Reyna A., Haagsma, Juanita A., Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Hassen, Tahir Ahmed, Havmoeller, Rasmus, Beatriz Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Heydarpour, Pouria, Hoek, Hans W., Hoffman, Howard J., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hutchings, Sally J., Huybrechts, Inge, Iburg, Kim Moesgaard, Idrisov, Bulat T., Ileanu, Bogdan Vasile, Inoue, Manami, Jacobs, Troy A., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Jansen, Henrica A. F. M., Jassal, Simerjot K., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Johnson, Catherine O., Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatibzadeh, Shahab, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kimokoti, Ruth W., Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D., Kokubo, Yoshihiro, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Kromhout, Hans, Krueger, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S., Bicer, Burcu Kucuk, Kuipers, Ernst J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lan, Qing, Larsson, Anders, Latif, Asma Abdul, Beatriz Lawrynowicz, Alicia Elena, Leasher, Janet L., Leigh, James, Leung, Janni, Levi, Miriam, Li, Xiaohong, Li, Yichong, Liang, Juan, Liu, Shiwei, Lloyd, Belinda K., Logroscino, Giancarlo, Lotufo, Paulo A., Lunevicius, Raimundas, Maclntyre, Michael, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manamo, Wondimu Ayele Ayele, Mapoma, Chabila C., Marcenes, Wagner, Martin, Randall V., Martinez-Raga, Jose, Masiye, Felix, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., McGrath, John J., McKee, Martin, Meaney, Peter A., Medina, Catalina, Mehari, Alem, Mena-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Mensink, Gert B. M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D., Parsaeian, Mahboubeh, Patel, Tejas, Caicedo, Angel J. Paternina, Patil, Snehal T., Patten, Scott B., Patton, George C., Pearce, Neil, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Murugesan, Ram, Usha, Rana, Saleem M., Ranganathan, Kavitha, Rao, Puja, Razo Garcia, Christian Aspacia, Refaat, Amany H., Rehm, Colin D., Rehm, Jurgen, Reinig, Nikolas, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Rivera, Juan A., Rolm, Hirbo Shore, Rodriguez, Anna, Rodriguez-Ramirez, Sonia, Rojas-Rueda, David, Roman, Yesenia, Ronfani, Luca, Roshandel, Gholamreza, Rothenbacher, Dietrich, Roy, Ambuj, Saleh, Muhammad Muhammad, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Sanchez-Pimienta, Tania G., Sandar, Logan, Santomauro, Damian F., Santos, Itamar S., Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schmidhuber, Josef, Schmidt, Maria Ines, Schneider, Ione J. C., Schoettker, Ben, Schutte, Aletta E., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shaheen, Amira, Shahraz, Saeid, Shaikh, Masood Ali, Levy, Teresa Shamah, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Sheth, Kevin N., Shi, Peilin, Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Silverberg, Jonathan I., Simard, Edgar P., Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A., Singh, Prashant Kumar, Slepak, Erica Leigh, Soljak, Michael, Soneji, Samir, Sorensen, Reed J. D., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steckling, Nadine, Steel, Nicholas, Stein, Dan J., Stein, Murray B., Stockl, Heidi, Stranges, Saverio, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takahashi, Ken, Talongwa, Roberto Tchio, Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Belaynew Wasie, Taylor, Hugh R., Tedla, Bemnet Amare, Tefera, Worku Mekonnen, Tegegne, Teketo Kassaw, Tekle, Dejen Yemane, Terkawi, Abdullah Sulieman, Thakur, J. S., Thomas, Bernadette A., Thomas, Matthew Lloyd, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tobe-Gai, Ruoyan, Tobollik, Myriam, Topor-Madry, Roman, Topouzis, Fotis, Towbin, Jeffrey Allen, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimparis, Nikolaos, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Donkelaar, Aaron, van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi, Veerman, J. Lennert, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, JianLi, Wang, Linhong, Wang, Yanping, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woolf, Anthony D., Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zhu, Jun, Zipkin, Ben, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Murray, Christopher J. L., Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. Ross, Bhutta, Zulficiar A., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Cercy, Kelly, Charlson, Fiona J., Cohen, Aaron J., Dandona, Lalit, Estep, Kara, Ferrari, Alize J., Frostad, Joseph J., Fullman, Nancy, Gething, Peter W., Godwin, William W., Griswold, Max, Kinfu, Yohannes, Kyu, Hmwe H., Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Liu, Patrick Y., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Neal, Bruce, Reitsma, Marissa B., Roth, Gregory A., Salomon, Joshua A., Sur, Patrick J., Vos, Theo, Wagner, Joseph A., Wang, Haidong, Zhao, Yi, Zhou, Maigeng, Aasvang, Gunn Marit, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abdulle, Abdishakur M., Abera, Semaw Ferede, Abraham, Biju, Abu-Raddad, Laith J., Abyu, Gebre Yitayih, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Ademi, Zanfina, Adou, Arsene Kouablan, Adsuar, Jose C., Agardh, Emilie Elisabet, Agarwal, Arnav, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ajala, Oluremi N., Akinyemiju, Tomi F., Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alsharif, Ubai, Altirkawi, Khalid A., Alvarez Martin, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwar, Palwasha, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Barac, Aleksandra, Barber, Ryan M., Barker-Collo, Suzanne L., Baernighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Basu, Sanjay, Bans, Carolina, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Boris, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D., Borschmann, Rohan, Boufous, Soufiane, Bourne, Rupert R. A., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Broday, David M., Brugha, Traolach S., Brunekreef, Bert, Butt, Zahid A., Cahill, Leah E., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cardenas, Rosario, Carpenter, David, Casey, Daniel C., Castaneda-Oquela, Carlos A., Castillo Rivas, Jacqueline, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Coates, Matthew M., Colquhoun, Samantha M., Cooper, Leslie Trumbull, Cooperrider, Kimberly, Cornaby, Leslie, Cortinovis, Monica, Crump, John A., Cuevas-Nasu, Lucia, Damasceno, Albertino, Dandona, Rakhi, Darby, Sarah C., Dargan, Paul I., das Neves, Jose, Davis, Adrian C., Davletov, Kairat, Filipa de Castro, E., De la Cruz-Gongora, Vanessa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribew, Amare, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Tome, Cesar, Dicker, Daniel, Ding, Eric L., Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. Gerry R., Franklin, Richard C., Fuerst, Thomas, Futran, Neal D., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Goenka, Shifalika, Carmen Gomez-Cabrera, Mari, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Gugnani, Harish Chander, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gutierrez, Reyna A., Haagsma, Juanita A., Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Hassen, Tahir Ahmed, Havmoeller, Rasmus, Beatriz Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Heydarpour, Pouria, Hoek, Hans W., Hoffman, Howard J., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hutchings, Sally J., Huybrechts, Inge, Iburg, Kim Moesgaard, Idrisov, Bulat T., Ileanu, Bogdan Vasile, Inoue, Manami, Jacobs, Troy A., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Jansen, Henrica A. F. M., Jassal, Simerjot K., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Johnson, Catherine O., Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatibzadeh, Shahab, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kimokoti, Ruth W., Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D., Kokubo, Yoshihiro, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Kromhout, Hans, Krueger, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S., Bicer, Burcu Kucuk, Kuipers, Ernst J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lan, Qing, Larsson, Anders, Latif, Asma Abdul, Beatriz Lawrynowicz, Alicia Elena, Leasher, Janet L., Leigh, James, Leung, Janni, Levi, Miriam, Li, Xiaohong, Li, Yichong, Liang, Juan, Liu, Shiwei, Lloyd, Belinda K., Logroscino, Giancarlo, Lotufo, Paulo A., Lunevicius, Raimundas, Maclntyre, Michael, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manamo, Wondimu Ayele Ayele, Mapoma, Chabila C., Marcenes, Wagner, Martin, Randall V., Martinez-Raga, Jose, Masiye, Felix, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., McGrath, John J., McKee, Martin, Meaney, Peter A., Medina, Catalina, Mehari, Alem, Mena-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Mensink, Gert B. M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D., Parsaeian, Mahboubeh, Patel, Tejas, Caicedo, Angel J. Paternina, Patil, Snehal T., Patten, Scott B., Patton, George C., Pearce, Neil, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Murugesan, Ram, Usha, Rana, Saleem M., Ranganathan, Kavitha, Rao, Puja, Razo Garcia, Christian Aspacia, Refaat, Amany H., Rehm, Colin D., Rehm, Jurgen, Reinig, Nikolas, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Rivera, Juan A., Rolm, Hirbo Shore, Rodriguez, Anna, Rodriguez-Ramirez, Sonia, Rojas-Rueda, David, Roman, Yesenia, Ronfani, Luca, Roshandel, Gholamreza, Rothenbacher, Dietrich, Roy, Ambuj, Saleh, Muhammad Muhammad, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Sanchez-Pimienta, Tania G., Sandar, Logan, Santomauro, Damian F., Santos, Itamar S., Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schmidhuber, Josef, Schmidt, Maria Ines, Schneider, Ione J. C., Schoettker, Ben, Schutte, Aletta E., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shaheen, Amira, Shahraz, Saeid, Shaikh, Masood Ali, Levy, Teresa Shamah, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Sheth, Kevin N., Shi, Peilin, Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Silverberg, Jonathan I., Simard, Edgar P., Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A., Singh, Prashant Kumar, Slepak, Erica Leigh, Soljak, Michael, Soneji, Samir, Sorensen, Reed J. D., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steckling, Nadine, Steel, Nicholas, Stein, Dan J., Stein, Murray B., Stockl, Heidi, Stranges, Saverio, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takahashi, Ken, Talongwa, Roberto Tchio, Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Belaynew Wasie, Taylor, Hugh R., Tedla, Bemnet Amare, Tefera, Worku Mekonnen, Tegegne, Teketo Kassaw, Tekle, Dejen Yemane, Terkawi, Abdullah Sulieman, Thakur, J. S., Thomas, Bernadette A., Thomas, Matthew Lloyd, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tobe-Gai, Ruoyan, Tobollik, Myriam, Topor-Madry, Roman, Topouzis, Fotis, Towbin, Jeffrey Allen, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimparis, Nikolaos, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Donkelaar, Aaron, van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi, Veerman, J. 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Abstract

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accou

Published
2016
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6. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015

Author

University of Helsinki, Clinicum, University of Helsinki, Department of Neurosciences, University of Helsinki, Department of Surgery, University of Helsinki, Department of Medical Genetics, Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. Ross, Bhutta, Zulficiar A., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Cercy, Kelly, Charlson, Fiona J., Cohen, Aaron J., Dandona, Lalit, Estep, Kara, Ferrari, Alize J., Frostad, Joseph J., Fullman, Nancy, Gething, Peter W., Godwin, William W., Griswold, Max, Kinfu, Yohannes, Kyu, Hmwe H., Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Liu, Patrick Y., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Neal, Bruce, Reitsma, Marissa B., Roth, Gregory A., Salomon, Joshua A., Sur, Patrick J., Vos, Theo, Wagner, Joseph A., Wang, Haidong, Zhao, Yi, Zhou, Maigeng, Aasvang, Gunn Marit, Amanuel, Abajobir, Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abdulle, Abdishakur M., Abera, Semaw Ferede, Abraham, Biju, Abu-Raddad, Laith J., Abyu, Gebre Yitayih, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Ademi, Zanfina, Adou, Arsene Kouablan, Adsuar, Jose C., Agardh, Emilie Elisabet, Agarwal, Arnav, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ajala, Oluremi N., Akinyemiju, Tomi F., Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alsharif, Ubai, Altirkawi, Khalid A., Alvarez Martin, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwar, Palwasha, Arnlov, Johan, Al Artaman, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Barac, Aleksandra, Barber, Ryan M., Barker-Collo, Suzanne L., Baernighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Basu, Sanjay, Bans, Carolina, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Boris, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D., Borschmann, Rohan, Boufous, Soufiane, Bourne, Rupert R. A., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Broday, David M., Brugha, Traolach S., Brunekreef, Bert, Butt, Zahid A., Cahill, Leah E., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cardenas, Rosario, Carpenter, David, Casey, Daniel C., Castaneda-Oquela, Carlos A., Castillo Rivas, Jacqueline, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Coates, Matthew M., Colquhoun, Samantha M., Cooper, Leslie Trumbull, Cooperrider, Kimberly, Cornaby, Leslie, Cortinovis, Monica, Crump, John A., Cuevas-Nasu, Lucia, Damasceno, Albertino, Dandona, Rakhi, Darby, Sarah C., Dargan, Paul I., das Neves, Jose, Davis, Adrian C., Davletov, Kairat, Filipa de Castro, E., De la Cruz-Gongora, Vanessa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribew, Amare, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Tome, Cesar, Dicker, Daniel, Ding, Eric L., Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. 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M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Quyen Le Nguyen, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D., Parsaeian, Mahboubeh, Patel, Tejas, Caicedo, Angel J. Paternina, Patil, Snehal T., Patten, Scott B., Patton, George C., Pearce, Neil, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Murugesan, Ram, Usha, Rana, Saleem M., Ranganathan, Kavitha, Rao, Puja, Razo Garcia, Christian Aspacia, Refaat, Amany H., Rehm, Colin D., Rehm, Jurgen, Reinig, Nikolas, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Rivera, Juan A., Rolm, Hirbo Shore, Rodriguez, Anna, Rodriguez-Ramirez, Sonia, Rojas-Rueda, David, Roman, Yesenia, Ronfani, Luca, Roshandel, Gholamreza, Rothenbacher, Dietrich, Roy, Ambuj, Saleh, Muhammad Muhammad, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Sanchez-Pimienta, Tania G., Sandar, Logan, Santomauro, Damian F., Santos, Itamar S., Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schmidhuber, Josef, Schmidt, Maria Ines, Schneider, Ione J. 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Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. Gerry R., Franklin, Richard C., Fuerst, Thomas, Futran, Neal D., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Goenka, Shifalika, Carmen Gomez-Cabrera, Mari, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Gugnani, Harish Chander, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gutierrez, Reyna A., Haagsma, Juanita A., Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Hassen, Tahir Ahmed, Havmoeller, Rasmus, Beatriz Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Heydarpour, Pouria, Hoek, Hans W., Hoffman, Howard J., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hutchings, Sally J., Huybrechts, Inge, Iburg, Kim Moesgaard, Idrisov, Bulat T., Ileanu, Bogdan Vasile, Inoue, Manami, Jacobs, Troy A., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Jansen, Henrica A. F. M., Jassal, Simerjot K., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Johnson, Catherine O., Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatibzadeh, Shahab, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kimokoti, Ruth W., Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D., Kokubo, Yoshihiro, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Kromhout, Hans, Krueger, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S., Bicer, Burcu Kucuk, Kuipers, Ernst J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lan, Qing, Larsson, Anders, Latif, Asma Abdul, Beatriz Lawrynowicz, Alicia Elena, Leasher, Janet L., Leigh, James, Leung, Janni, Levi, Miriam, Li, Xiaohong, Li, Yichong, Liang, Juan, Liu, Shiwei, Lloyd, Belinda K., Logroscino, Giancarlo, Lotufo, Paulo A., Lunevicius, Raimundas, Maclntyre, Michael, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manamo, Wondimu Ayele Ayele, Mapoma, Chabila C., Marcenes, Wagner, Martin, Randall V., Martinez-Raga, Jose, Masiye, Felix, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., McGrath, John J., McKee, Martin, Meaney, Peter A., Medina, Catalina, Mehari, Alem, Mena-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Mensink, Gert B. M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Quyen Le Nguyen, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. 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Abstract

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accou

Published
2016

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