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Objective Premature adrenarche (PA) has been suggested as a risk factor for future health problems, such as metabolic syndrome and early menarche. However, not all girls with PA have these features and it is not certain who will develop them. We propose that these abnormalities might be identified earlier, even before they are visible. Design Case-control study. Setting Tertiary care hospital. Participants Forty-eight girls with premature pubarche due to PA and age (mean age 7.6 +/- 1.0 years), weight, body mass index (BMI), birth weight and gestational age-matched 49 girls with no palpable breast tissue. Measurements Early pubertal pelvic and breast ultrasonographic changes and their associations with obesity and metabolic parameters were evaluated. Blood samples were collected, breast and pelvic ultrasound examinations were performed and bone ages were assessed. Results Girls with PA were taller and their bone ages were higher (p = .049 and p = .005). Fasting blood glucose, insulin, triglycerides, high-density lipoprotein and low-density lipoprotein cholesterol were not different between the groups. Luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol were not different either. Ultrasonography revealed breast gland tissue in 30% of girls with PA and 5% of controls (p = .006). Uterine volume and endometrial thickness were higher in girls with PA (p = .03 and p = .04). Endometrial thickness was positively associated with serum insulin levels in the whole study group and after adjusting for age, diagnosis, BMI, mean ovarian volume and LH, FSH, estradiol levels, this association remained with a borderline p-value (R-2 = 0.486, p = .050). Conclusions We found early changes in uterus and breast glands of girls with PA and endometrial thickness was positively associated with insulin levels.

Onsekiz yaş altında evlenme olarak tanımlanan erken evlilik, okulu bırakma nedeniyle düşük eğitim seviyesi, adolesan gebelik, anne ve bebek mortalite ve morbiditesinde artış, yoksulluk gibi çeşitli olumsuz sonuçlara yol açmaktadır. Bu olumsuz sonuçlar sadece kişileri değil, onların çocuklarını ve toplumu da etkileyebilme potansiyeline sahiptir. Bu derleme yazıda, ülkemizde ve dünyada çocuk gelinler konusundaki durumun incelenmesi ve erken evliliğin önlenmesine yönelik önerilerin değerlendirilmesi amaçlanmıştır. Yoksulluk ve düşük eğitim seviyesi çocuk evliliğine katkıda bulunan en önemli faktörlerdir. Erken evliliklerin önlenmesinde en etkin çözüm,kızların eğitimine odaklanan ve sosyal eşitsizliğin azaltılmasını hedef alan program stratejileri olarak görülmektedir.Anahtar kelimeler: Erken evlilik, Çocuk gelinler, Adolesan gebelik, Early marriage, defined as marriage before 18 years of age, has been associated with a variety of negative outcomes such as low education status due to dropping out of school, teenage pregnancies, increased maternal and infant mortality and poverty. The negative outcomes have the potential to affect not only the individuals but also their children and the community. This review article aimed to investigate the issue of child marriage in our country and around the globe, and to evaluate the recommendations for the prevention of early marriage. Poverty and low education status are the most important factors contributing to child marriage. Promoting strategies focusing on girls’ education and targeting social inequalities seem to be the most effective solutions to prevent child marriage