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1. Bioarchaeology aids the cultural understanding of six characters in search of their agency (Tarquinia, ninth–seventh century BC, central Italy)

Author

Bagnasco, G., Marzullo, M., Cattaneo, C., Biehler-Gomez, L., Mazzarelli, D., Ricciardi, V., Müller, W., Coppa, A., McLaughlin, R., Motta, L., Prato, O., Schmidt, F., Gaveriaux, F., Marras, G. B., Millet, M. A., Madgwick, R., Ballantyne, R., Makarewicz, C.A., Trentacoste, A., Reimer, P., Mattiangeli, V., Bradley, D. G., Malone, C., Esposito, C., Breslin, E. M., and Stoddart, S.

Published
2024
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3. Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Author

Coppo, R., Feehaly, J., Troyanov, S., Cattran, D.C., Cook, H.T., Roberts, I., Radcliffe, John, Russo, M.L., Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Piras, D., Angioi, A., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Papagianni, K., Stangou, M., Giacchino, F., Goumenos, D., Papasotirious, M., Kalliakmani, P., Gerolymos, M., Galesic, K., Toric, L., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Kloster Smerud, H., Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Boria Grinyo, J.M., Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Hryszko, T., Klinger, M., Kamińska, D., Krajewska, M., Martina, G., Messuerotti, A., Dal Canton, A., Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Cambier, A., Bellur, S., Mazzucco, G., Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Diomedi-Casadei, F., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Arce Terroba, J., Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., Galesic Ljubanovic, D., Gakiopoulou, H., Bertoni, E., Cannata Ortiz, P., Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., Fulladosa Oliveras, X., Maldyk, J., Ioachim, E., Royal, V., Bellur, Shubha S., Troyanov, Stéphan, Vorobyeva, Olga, Coppo, Rosanna, and Roberts, Ian S.D.

Published
2024
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6. Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy

Author

Russo, M.L., Troyanov, S., Cook, H.T., Roberts, I., Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Piras, D., Angioi, A., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Stangou, M., Giacchino, F., Goumenos, D., Papachristou, E., Galesic, K., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Smerud, H. Kloster, Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Boria Grinyo, J.M., Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Martina, G., Messuerotti, A., Dal Canton, A., Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Bellur, S., Mazzucco, G., Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Terroba, J. Arce, Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., Ljubanovic, D. Galesic, Gakiopoulou, H., Bertoni, E., Cannata Ortiz, P., Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., Fulladosa Oliveras, X., Maldyk, J., Ioachim, E., Bavbek, N., Cook, T., Alpers, C., Berthoux, F., Bonsib, S., D’Agati, V., D’Amico, G., Emancipator, S., Emmal, F., Fervenza, F., Florquin, S., Fogo, A., Groene, H., Haas, M., Hill, P., Hogg, R., Hsu, S., Hunley, T., Hladunewich, M., Jennette, C., Joh, K., Julian, B., Kawamura, T., Lai, F., Leung, C., Li, L., Li, P., Liu, Z., Massat, A., Mackinnon, B., Mezzano, S., Schena, F., Tomino, Y., Walker, P., Wang, H., Weening, J., Yoshikawa, N., Zeng, C.-H., Shi, S., Nogi, C., Suzuki, H., Koike, K., Hirano, K., Yokoo, T., Hanai, M., Fukami, K., Takahashi, K., Yuzawa, Y., Niwa, M., Yasuda, Y., Maruyama, S., Ichikawa, D., Suzuki, T., Shirai, S., Fukuda, A., Fujimoto, S., Trimarchi, H., Barbour, Sean J., Coppo, Rosanna, Zhang, Hong, Liu, Zhi-Hong, Suzuki, Yusuke, Matsuzaki, Keiichi, Er, Lee, Reich, Heather N., Barratt, Jonathan, and Cattran, Daniel C.

Published
2022
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8. Reliability assessment of open-source multiscale landslide susceptibility maps and effects of their fusion.

Author

Mastrantoni, G., Marmoni, G. M., Esposito, C., Bozzano, F., Scarascia Mugnozza, G., and Mazzanti, P.

Subjects
MACHINE learning, LANDSLIDE hazard analysis, LANDSLIDE prediction, RISK managers, MULTISENSOR data fusion
Abstract

Several landslide susceptibility (LS) maps at various scales of analysis have been performed with specific zoning purposes and techniques. Supervised machine learning algorithms (ML) have become one of the most diffused techniques for landslide prediction, whose reliability is firmly based on the quality of input data. Site-specific landslide inventories are often more accurate and complete than national or worldwide databases. For these reasons, detailed landslide inventory and predisposing variables must be collected to derive reliable LS products. However, high-quality data are often rare, and risk managers must consider lower-resolution available products with no more than informative purposes. In this work, we compared different ML models to select the most accurate for large-scale LS assessment within the Municipality of Rome. The ExtraTreesClassifier outperformed the others reaching an average F1-score of 0.896. Thereafter, we addressed the reliability of open-source LS maps at different scales of analysis (global to regional) by means of statistical and spatial analysis. The obtained results shed light on the difference in hazard zoning depending on the scale and mapping unit. An approach for low-resolution LS data fusion was attempted, assessing the importance of the adopted criteria, which increased the ability to detect occurred landslides while maintaining precision. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Development and testing of an artificial intelligence tool for predicting end-stage kidney disease in patients with immunoglobulin A nephropathy

Author

Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Coppo, R., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Angioi, A., Piras, L., Feehally, J., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Stangou, M., Giacchino, F., Goumenos, D., Papasotiriou, M., Galesic, K., Toric, L., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Smerud, H. Kloster, Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Rauen, T., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Grinyo, J.M. Boria, Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Martina, G., Messuerotti, A., Canton, A. Dal, Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Mazzucco, Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Terroba, J. Arce, Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., GalesicLjubanovic, D., Gakiopoulou, H., Bertoni, E., Ortiz, P. Cannata, Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., FulladosaOliveras, X., Maldyk, J., Ioachim, E., Abbrescia, Daniela, Kouri, Nikoleta, Stangou, Maria, Papagianni, Aikaterini, Scolari, Francesco, Delbarba, Elisa, Bonomini, Mario, Piscitani, Luca, Stallone, Giovanni, Infante, Barbara, Godeas, Giulia, Madio, Desiree, Biancone, Luigi, Campagna, Marco, Zaza, Gianluigi, Squarzoni, Isabella, Cangemi, Concetta, Schena, Francesco Paolo, Anelli, Vito Walter, Trotta, Joseph, Di Noia, Tommaso, Manno, Carlo, Tripepi, Giovanni, D’Arrigo, Graziella, Chesnaye, Nicholas C., Russo, Maria Luisa, Zoccali, Carmine, Tesar, Vladimir, and Coppo, Rosanna

Published
2021
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12. Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool

Author

Russo, M.L., Troyanov, S., Cook, H.T., Roberts, I., Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Piras, D., Angioi, A., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Stangou, M., Giacchino, F., Goumenos, D., Kalliakmani, P., Gerolymos, M., Galesic, K., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Kloster Smerud, H., Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Boria Grinyo, J.M., Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Martina, G., Messuerotti, A., Dal Canton, A., Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Bellur, S., Mazzucco, G., Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Arce Terroba, J., Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., Galesic Ljubanovic, D., Gakiopoulou, H., Bertoni, E., Cannata Ortiz, P., Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., Fulladosa Oliveras, X., Maldyk, J., Ioachim, E., Bavbek, N., Cook, T., Alpers, C., Berthoux, F., Bonsib, S., D’Agati, V., D’Amico, G., Emancipator, S., Emmal, F., Fervenza, F., Florquin, S., Fogo, A., Groene, H., Haas, M., Hill, P., Hogg, R., Hsu, S., Hunley, T., Hladunewich, M., Jennette, C., Joh, K., Julian, B., Kawamura, T., Lai, F., Leung, C., Li, L., Li, P., Liu, Z., Massat, A., Mackinnon, B., Mezzano, S., Schena, F., Tomino, Y., Walker, P., Wang, H., Weening, J., Yoshikawa N, N., Zeng, C.-H., Shi, S., Nogi, C., Suzuki, H., Koike, K., Hirano, K., Yokoo, T., Hanai, M., Fukami, K., Takahashi, K., Yuzawa, Y., Niwa, M., Yasuda, Y., Maruyama, S., Ichikawa, D., Suzuki, T., Shirai, S., Fukuda, A., Fujimoto, S., Trimarchi, H., Barbour, Sean J., Canney, Mark, Coppo, Rosanna, Zhang, Hong, Liu, Zhi-Hong, Suzuki, Yusuke, Matsuzaki, Keiichi, Katafuchi, Ritsuko, Induruwage, Dilshani, Er, Lee, Reich, Heather N., Feehally, John, Barratt, Jonathan, and Cattran, Daniel C.

Published
2020
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13. Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine

Author

Esposito, C, De Cagna, F, Caldiroli, A, Capuzzi, E, Ceresa, A, Di Paolo, M, Auxilia, A, Capellazzi, M, Tagliabue, I, Cirella, L, Clerici, M, Brondino, N, Barkin, J, Politi, P, Buoli, M, Esposito C. M., De Cagna F., Caldiroli A., Capuzzi E., Ceresa A., Di Paolo M., Auxilia A. M., Capellazzi M., Tagliabue I., Cirella L., Clerici M., Brondino N., Barkin J. L., Politi P., Buoli M., Esposito, C, De Cagna, F, Caldiroli, A, Capuzzi, E, Ceresa, A, Di Paolo, M, Auxilia, A, Capellazzi, M, Tagliabue, I, Cirella, L, Clerici, M, Brondino, N, Barkin, J, Politi, P, Buoli, M, Esposito C. M., De Cagna F., Caldiroli A., Capuzzi E., Ceresa A., Di Paolo M., Auxilia A. M., Capellazzi M., Tagliabue I., Cirella L., Clerici M., Brondino N., Barkin J. L., Politi P., and Buoli M.

Abstract

Background: The scientific literature shows some gender differences in the clinical course of schizophrenia. The aim of this study is to identify gender differences in clinical and biochemical parameters in subjects affected by schizophrenia. This would allow for the implementation of individualized treatment strategies. Methods: We examined a large set of clinical and biochemical parameters. Data were obtained from clinical charts and blood analyses from a sample of 555 schizophrenia patients consecutively admitted for exacerbation of symptoms to the inpatient clinic of Fondazione IRCCS Policlinico (Milan) or ASST Monza in Italy from 2008 to 2021. Univariate analyses, binary logistic regression, and a final logistic regression model were performed with gender as dependent variable. Results: The final logistic regression models showed that male patients (compared to females) were more prone to lifetime substance use disorders (p = 0.010). However, they also had higher GAF (global functioning) mean scores (p < 0.001) at the time of hospitalization. Univariate analyses showed that male patients (with respect to females) had an earlier age at onset (p < 0.001), a more frequent family history of multiple psychiatric disorders (p = 0.045), were more often smokers (p < 0.001), had a more frequent comorbidity with at least one psychiatric disorder (p = 0.001), and less often suffered from hypothyroidism (p = 0.011). In addition, men had higher levels of albumin (p < 0.001) and bilirubin (t = 2.139, p = 0.033), but lower levels of total cholesterol (t = 3.755, p < 0.001). Conclusions: Our analyses indicate a less severe clinical profile in female patients. This is evident especially in the early years of the disorder, as suggested by less comorbidity with psychiatric disorders or later age at onset; this is consistent with the related literature. In contrast, female patients seem to be more vulnerable to metabolic alterations as demonstrated by more freq

Published
2023

14. Which clinical factors and biochemical parameters are associated with late-life major depression?

Author

Buoli, M, Legnani, F, Nosari, G, Pan, A, Ciappolino, V, Esposito, C, Ceresa, A, Di Paolo, M, Surace, T, Auxilia, A, Capellazzi, M, Tagliabue, I, Cirella, L, Zanelli Quarantini, F, Dakanalis, A, Clerici, M, Capuzzi, E, Caldiroli, A, Buoli M., Legnani F., Nosari G., Pan A., Ciappolino V., Esposito C. M., Ceresa A., Di Paolo M., Surace T., Auxilia A. M., Capellazzi M., Tagliabue I., Cirella L., Zanelli Quarantini F., Dakanalis A., Clerici M., Capuzzi E., Caldiroli A., Buoli, M, Legnani, F, Nosari, G, Pan, A, Ciappolino, V, Esposito, C, Ceresa, A, Di Paolo, M, Surace, T, Auxilia, A, Capellazzi, M, Tagliabue, I, Cirella, L, Zanelli Quarantini, F, Dakanalis, A, Clerici, M, Capuzzi, E, Caldiroli, A, Buoli M., Legnani F., Nosari G., Pan A., Ciappolino V., Esposito C. M., Ceresa A., Di Paolo M., Surace T., Auxilia A. M., Capellazzi M., Tagliabue I., Cirella L., Zanelli Quarantini F., Dakanalis A., Clerici M., Capuzzi E., and Caldiroli A.

Abstract

Introduction: Late-life major depression (MD) is a frequent and high-cost psychiatric disorder. Our purpose was to detect clinical and biological factors possibly associated with this condition to better prevent and treat it. Methods: We recruited 343 patients, consecutively admitted for a Major Depressive Episode to the inpatient clinic of Policlinico of Milan and ASST Monza, Italy. A large set of clinical and biochemical variables was collected from clinical charts. Univariate analyses were performed both dividing the sample into two groups (age < or ≥65) and considering age as a continuous quantitative variable. Regression analyses were then performed considering as independent variables only those statistically significant at univariate analyses. Results: Patients aged ≥ 65 resulted in having longer duration of illness, shorter duration of last antidepressant therapy, higher number of antidepressants assumed in the past, higher frequency of treatment-resistant depression, higher frequency of overweight/obesity and diabetes. As for biochemical parameters, patients ≥ 65 showed lower total plasmatic proteins and albumin, higher uric acid and creatinine. Conclusions: These preliminary results suggest less effectiveness of antidepressants, more susceptibility to metabolic disorders and poor nutritional status in patients with late-life depression; such aspects may consequently be taken into consideration for a proper therapeutic approach. KEY POINTS Depression in late life seems to be associated with poorer response to antidepressants; Clinicians should prefer compounds with minimal pharmacokinetic interactions and less risk of side effects including metabolic ones; The poor nutritional status and the higher risk of metabolic disorders in older patients points out the importance of proper diet and healthy lifestyle in this group of subjects; Further studies are needed to confirm the results of this research.

Published
2023

17. PCR153 Pace CKD: The Impact of Chronic Kidney Disease and Dialysis on Caregivers Financial Status, and Work Productivity: Results from a Multinational Survey

Author

Garcia Sanchez, J.J., primary, Wu, M.S., additional, Reichel, H., additional, Elsayed, H., additional, Rangaswami, J., additional, Correa-Rotter, R., additional, Hull, R., additional, Esposito, C., additional, Chadban, S., additional, Pentakota, S., additional, West, B., additional, Mellor, R., additional, Kularatne, T., additional, and Fifer, S., additional

Published
2023
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18. PCR208 Pace CKD Financial Burden and Work Productivity Assessment of Chronic Kidney Disease on Patients: Results from an International Survey

Author

Garcia Sanchez, J.J., primary, Elsayed, H., additional, Esposito, C., additional, Rangaswami, J., additional, Wu, M.S., additional, Hull, R., additional, Chadban, S., additional, Reichel, H., additional, Correa-Rotter, R., additional, Pentakota, S., additional, West, B., additional, Mellor, R., additional, Kularatne, T., additional, and Fifer, S., additional

Published
2023
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20. 409 Exploring cystic fibrosis providers’ perceptions of palliative care performance: baseline data from the Improving Life with Cystic Fibrosis multisite implementation trial for primary palliative care intervention

Author

Dhingra, L., primary, DiFiglia, S., additional, Portenoy, R., additional, Wang, J., additional, Walker, P., additional, Middour-Oxler, B., additional, Linnemann, R., additional, Kier, C., additional, Friedman, D., additional, Berdella, M., additional, Stables-Carney, T., additional, Trentacoste, J., additional, Plachta, A., additional, Henthorne, K., additional, Frantzen, T., additional, Esposito, C., additional, Chaudhary, N., additional, Buehler, B., additional, and Georgiopoulos, A., additional

Published
2023
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21. 411 The Improving Life with Cystic Fibrosis multisite implementation trial for primary palliative care intervention in U.S. cystic fibrosis centers: initial uptake and feasibility data

Author

DiFiglia, S., primary, Georgiopoulos, A., additional, Portenoy, R., additional, Chaudhary, N., additional, Yonker, L., additional, Wang, J., additional, Walker, P., additional, Middour-Oxler, B., additional, Linnemann, R., additional, Kier, C., additional, Friedman, D., additional, Diener, B., additional, Berdella, M., additional, Weinstein, S., additional, Trentacoste, J., additional, Stables-Carney, T., additional, Roncone, S., additional, Pollinger, S., additional, Plachta, A., additional, Henthorne, K., additional, Frantzen, T., additional, Esposito, C., additional, Buehler, B., additional, and Dhingra, L., additional

Published
2023
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31. Robotic-assisted pyeloplasty in children: a systematic review of the literature

Author

Esposito, C, Cerulo, M, Lepore, B, Coppola, V, D'Auria, D, Esposito, G, Carulli, R, Del Conte, F, Escolino, M, Esposito, C, Cerulo, M, Lepore, B, Coppola, V, D'Auria, D, Esposito, G, Carulli, R, Del Conte, F, and Escolino, M

Abstract

Robotic pyeloplasty has become a natural progression from the development of open, then laparoscopic procedures to treat pediatric patients with ureteropelvic junction obstruction (UPJO). Robotic-assisted pyeloplasty (RALP) is now considered a new gold standard in pediatric MIS. A systematic review of the literature retrieved from PubMed and published in the last 10 years (2012–2022) was performed. This review underlines that in all children except the smallest infants, where the open procedure has benefits in terms of duration of general anesthetic and there are limitations in the size of instruments, robotic pyeloplasty is becoming the preferred procedure to perform in patients with UPJO. Results for the robotic approach are extremely promising, with shorter operative times than laparoscopy and equal success rates, length of stay and complications. In case of redo pyeloplasty, RALP is easier to perform than other open or MIS procedures. By 2009, robotic surgery became the most used modality to treat all UPJO and continues to grow in popularity. Robot-assisted laparoscopic pyeloplasty in children is safe and effective with excellent outcomes, even in redo pyeloplasty or challenging anatomical cases. Moreover, robotic approach shortens the learning curve for junior surgeons, who can readily achieve levels of expertise comparable to senior practitioners. However, there are still concerns regarding the cost associated with this procedure. Further high-quality prospective observational studies and clinical trials, as well as new technologies specific for the pediatric population, are advisable for RALP to reach the level of gold standard.

Published
2023

32. Five Level Triage vs. Four Level Triage in a Quaternary Emergency Department: National Analysis on Waiting Time, Validity, and Crowding—The CREONTE (Crowding and RE-Organization National TriagE) Study Group

Author

Savioli, G., Ceresa, I. F., Bressan, M. A., Piccini, G. B., Varesi, Pietro Antonio, Novelli, Valeria, Muzzi, Antonella, Cutti, S., Ricevuti, G., Esposito, Carlo, Voza, A., Desai, A., Longhitano, Y., Saviano, Angela, Piccioni, Andrea, Piccolella, F., Bellou, A., Zanza, C., Oddone, E., Varesi A. (ORCID:0000-0002-9189-2352), Novelli V., Muzzi A., Esposito C., Saviano A. (ORCID:0000-0002-2820-7180), Piccioni A., Savioli, G., Ceresa, I. F., Bressan, M. A., Piccini, G. B., Varesi, Pietro Antonio, Novelli, Valeria, Muzzi, Antonella, Cutti, S., Ricevuti, G., Esposito, Carlo, Voza, A., Desai, A., Longhitano, Y., Saviano, Angela, Piccioni, Andrea, Piccolella, F., Bellou, A., Zanza, C., Oddone, E., Varesi A. (ORCID:0000-0002-9189-2352), Novelli V., Muzzi A., Esposito C., Saviano A. (ORCID:0000-0002-2820-7180), and Piccioni A.

Abstract

Background and Objectives: Triage systems help provide the right care at the right time for patients presenting to emergency departments (EDs). Triage systems are generally used to subdivide patients into three to five categories according to the system used, and their performance must be carefully monitored to ensure the best care for patients. Materials and Methods: We examined ED accesses in the context of 4-level (4LT) and 5-level triage systems (5LT), implemented from 1 January 2014 to 31 December 2020. This study assessed the effects of a 5LT on wait times and under-triage (UT) and over-triage (OT). We also examined how 5LT and 4LT systems reflected actual patient acuity by correlating triage codes with severity codes at discharge. Other outcomes included the impact of crowding indices and 5LT system function during the COVID-19 pandemic in the study populations. Results: We evaluated 423,257 ED presentations. Visits to the ED by more fragile and seriously ill individuals increased, with a progressive increase in crowding. The length of stay (LOS), exit block, boarding, and processing times increased, reflecting a net raise in throughput and output factors, with a consequent lengthening of wait times. The decreased UT trend was observed after implementing the 5LT system. Conversely, a slight rise in OT was reported, although this did not affect the medium-high-intensity care area. Conclusions: Introducing a 5LT improved ED performance and patient care.

Published
2023

34. Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

Author

Surace, T, Capuzzi, E, Caldiroli, A, Ceresa, A, Esposito, C, Auxilia, A, Tagliabue, I, Capellazzi, M, Legnani, F, Di Paolo, M, Cirella, L, Zanelli Quarantini, F, Signorelli, M, Aguglia, E, Clerici, M, Buoli, M, Surace T., Capuzzi E., Caldiroli A., Ceresa A., Esposito C. M., Auxilia A. M., Tagliabue I., Capellazzi M., Legnani F., Di Paolo M., Cirella L., Zanelli Quarantini F., Signorelli M. S., Aguglia E., Clerici M., Buoli M., Surace, T, Capuzzi, E, Caldiroli, A, Ceresa, A, Esposito, C, Auxilia, A, Tagliabue, I, Capellazzi, M, Legnani, F, Di Paolo, M, Cirella, L, Zanelli Quarantini, F, Signorelli, M, Aguglia, E, Clerici, M, Buoli, M, Surace T., Capuzzi E., Caldiroli A., Ceresa A., Esposito C. M., Auxilia A. M., Tagliabue I., Capellazzi M., Legnani F., Di Paolo M., Cirella L., Zanelli Quarantini F., Signorelli M. S., Aguglia E., Clerici M., and Buoli M.

Abstract

Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients. Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD. Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) (p = 0.005), absence of lifetime psychotic symptoms (p = 0.025), presence of poly-substance use disorders (p = 0.033), comorbidity with obesity (p = 0.022), a last mood episode of manic polarity (p = 0.044), and lower bilirubin serum levels (p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance (p = 0.058). Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings.

Published
2022

35. Gender differences in clinical and biochemical parameters of patients consecutively hospitalized for unipolar depression

Author

Ceresa, A, Esposito, C, Surace, T, Legnani, F, Cirella, L, Cetti, D, Di Paolo, M, Nosari, G, Zanelli Quarantini, F, Serati, M, Ciappolino, V, Caldiroli, A, Capuzzi, E, Buoli, M, Ceresa A., Esposito C. M., Surace T., Legnani F., Cirella L., Cetti D., Di Paolo M., Nosari G., Zanelli Quarantini F., Serati M., Ciappolino V., Caldiroli A., Capuzzi E., Buoli M., Ceresa, A, Esposito, C, Surace, T, Legnani, F, Cirella, L, Cetti, D, Di Paolo, M, Nosari, G, Zanelli Quarantini, F, Serati, M, Ciappolino, V, Caldiroli, A, Capuzzi, E, Buoli, M, Ceresa A., Esposito C. M., Surace T., Legnani F., Cirella L., Cetti D., Di Paolo M., Nosari G., Zanelli Quarantini F., Serati M., Ciappolino V., Caldiroli A., Capuzzi E., and Buoli M.

Abstract

Major Depressive Disorder (MDD) is a medical illness twice as common in women than in men lifetime. Purpose of this study is to identify gender differences in clinical and biochemical parameters in subjects affected by MDD to implement individualized treatment strategies. We recruited 234 patients (112 males and 122 females) consecutively hospitalized for MDD in Milan (Italy). Data were obtained through a screening of the clinical charts and blood analyses. Univariate analyses, binary logistic regressions and a final logistic regression model were performed. The final logistic regression model showed that female patients (compared to males) had lower plasmatic levels of hemoglobin (p = 0.020) and uric acid (p = 0.002), higher levels of cholesterol (p < 0.001), had been treated with a lower number of antidepressants (p = 0.011), presented lower red blood cells (p < 0.001) and showed more frequently comorbidity with hypothyroidism (p = 0.036). Univariate analyses identified also that women had an earlier age at onset (p = 0.043), were less likely to have comorbidity with diabetes (p = 0.002) and were less frequently treated with a psychiatric polytherapy (p < 0.001). Finally, female patients had achieved more frequently remission in the last depressive episode (p = 0.001) and were more likely to have family history for psychiatric disorders (p < 0.001) than males. Female patients globally have a better response to treatments, but they seem to be more vulnerable to specific metabolic abnormalities as showed by more frequent hypercholesterolemia and lower plasma levels of uric acid. These results have to be confirmed by further studies.

Published
2022

36. Clinical and Biological Factors Are Associated with Treatment-Resistant Depression

Author

Buoli, M, Capuzzi, E, Caldiroli, A, Ceresa, A, Esposito, C, Posio, C, Auxilia, A, Capellazzi, M, Tagliabue, I, Surace, T, Legnani, F, Cirella, L, Di Paolo, M, Nosari, G, Quarantini, F, Clerici, M, Colmegna, F, Dakanalis, A, Buoli M., Capuzzi E., Caldiroli A., Ceresa A., Esposito C. M., Posio C., Auxilia A. M., Capellazzi M., Tagliabue I., Surace T., Legnani F., Cirella L., Di Paolo M., Nosari G., Quarantini F. Z., Clerici M., Colmegna F., Dakanalis A., Buoli, M, Capuzzi, E, Caldiroli, A, Ceresa, A, Esposito, C, Posio, C, Auxilia, A, Capellazzi, M, Tagliabue, I, Surace, T, Legnani, F, Cirella, L, Di Paolo, M, Nosari, G, Quarantini, F, Clerici, M, Colmegna, F, Dakanalis, A, Buoli M., Capuzzi E., Caldiroli A., Ceresa A., Esposito C. M., Posio C., Auxilia A. M., Capellazzi M., Tagliabue I., Surace T., Legnani F., Cirella L., Di Paolo M., Nosari G., Quarantini F. Z., Clerici M., Colmegna F., and Dakanalis A.

Abstract

Background: Treatment-resistant depression (TRD) is a debilitating condition associated with unmet clinical needs. Few studies have explored clinical characteristics and serum biomarkers associated with TRD. Aims: We investigated whether there were differences in clinical and biochemical variables between patients affected by TRD than those without. Methods: We recruited 343 patients (165 males and 178 females) consecutively hospitalized for MDD to the inpatient clinics affiliated to the Fondazione IRCCS Policlinico, Milan, Italy (n = 234), and ASST Monza, Italy (n = 109). Data were obtained through a screening of the clinical charts and blood analyses conducted during the hospi-talization. Results: TRD versus non-TRD patients resulted to be older (p = 0.001), to have a longer duration of illness (p < 0.001), to be more currently treated with a psychiatric poly-therapy (p < 0.001), to have currently more severe depressive symptoms as showed by the Hamilton Depression Rating Scale (HAM-D) scores (p = 0.016), to have lower bilirubin plasma levels (p < 0.001). In addition, more lifetime suicide attempts (p = 0.035), more antidepressant treatments before the current episode (p < 0.001), and a lower neutrophil to lymphocyte ratio at borderline statistically significant level (p = 0.060) were all associated with the TRD group. Conclusion: We identified candidate biomarkers associated with TRD such as bilirubin plasma levels and NLR, to be confirmed by further studies. Moreover, TRD seems to be associated with unfavorable clinical factors such as a predisposition to suicidal behaviors. Future research should replicate these results to provide robust data in support of the identification of new targets of treatment and implementation of prevention strategies for TRD.

Published
2022

38. Are there any differences in clinical and biochemical variables between bipolar patients with or without lifetime psychotic symptoms?

Author

Esposito, C. M., primary, Ceresa, A., additional, Di Paolo, M., additional, Surace, T., additional, Moioli, L., additional, Legnani, F., additional, Nosari, G., additional, Ciappolino, V., additional, Auxilia, A. M., additional, Cappellazzi, M., additional, Tagliabue, I., additional, Cirella, L., additional, Capuzzi, E., additional, Caldiroli, A., additional, Dekanalis, A., additional, Clerici, M., additional, and Buoli, M., additional

Published
2023
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39. Clinical and biochemical parameters associated with substance-induced psychotic disorder: which differences between alcohol, cannabis and psychostimulants

Author

Nosari, G., primary, Ceresa, A., additional, Di Paolo, M., additional, Esposito, C. M., additional, Ciappolino, V., additional, Calabrese, A., additional, Legnani, F., additional, Auxilia, A. M., additional, Capellazzi, M., additional, Tagliabue, I., additional, Cirella, L., additional, Capuzzi, E., additional, Caldiroli, A., additional, Dakanalis, A., additional, Clerici, M., additional, and Buoli, M., additional

Published
2023
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48. Remote working during the COVID-19 pandemic: A study on the emotional and relational experience and on the well-being of Italian university scholars and clerks

Author

Esposito C., Agueli B., Arcidiacono C., Di Napoli I., Esposito, C., Agueli, B., Arcidiacono, C., and Di Napoli, I.

Subjects
affect, well-being, COVID-19 pandemic, remote working, Grounded Theory Methodology
Abstract

Introduction: This study investigated the emotions, relational experience and well-being of university scholars and clerks who continued their activities working remotely during the Italian lockdown period (March and April 2020). Methods: Eighty-seven workers (55% scholars and 45% university clerks) filled out an online quali-quantitative questionnaire about their work remotely during the lockdown. Qualitative data were analyzed through Grounded Theory Methodology. Then cross-tabs were created to intertwine the code groups that emerged with work role and gender of participants and frequencies were analyzed by Chi square test. Data were also analyzed through Univariate Analysis of Variance (ANOVA). Results: The results showed that scholars consider remote working mainly as a critical issue, while clerks see it more as a resource. Clerks more frequently reported negative affectivity such as anxiety, fear and anger, while scholars more frequently reported loneliness. Regarding interpersonal relationships, no significant differences between scholars and clerks were observed. Moreover, clerks reported lower physical, psychological, economic and overall well-being compared to scholars. Conclusions: This study highlights the importance of the mattering role of human relations in work activities. Without taking into account the emotional and relational needs of the workers, remote working can have negative effects on well-being. Keywords: remote working; COVID-19 pandemic; well-being; affects; Grounded Theory Methodology, Psychology Hub, Vol. 39 No. 1 (2022): Special Issue Effect of Covid-19 pandemic: vulnerability and resources. Part 2

Published
2022
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49. Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial

Author

Normanno, N., Rachiglio, A.M., Lambiase, M., Martinelli, E., Fenizia, F., Esposito, C., Roma, C., Troiani, T., Rizzi, D., Tatangelo, F., Botti, G., Maiello, E., Colucci, G., Ciardiello, F., Giuliani, F., Simone, G., Febbraro, A., Tommaselli, E., Cinieri, S., Criscuolo, M., Perrino, A., Rinaldi, A., Bordonaro, R., Manusia, M., Romito, S., Bufo, P., Cartenì, G., Biglietto, M., Nappi, O., Cardarelli, A., Montesarchio, E., Micheli, P., Nasti, G., Chicchinelli, N., Iannaccone, A., Russo, A., Cabibi, D., Giaccone, P., Barone, C., Rindi, G., Tonini, G., Onetti Muda, A., Perrone, G., Latiano, T., Graziano, P., Pisconti, S., and Sebastio, A.

Published
2015
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