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1. IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia

Author

Garcia-Solorio, Joaquin, primary, Núñez-Enriquez, Juan Carlos, additional, Jiménez-Olivares, Marco, additional, Flores-Lujano, Janet, additional, Flores-Espino, Fernanda, additional, Molina-Garay, Carolina, additional, Cervera, Alejandra, additional, Casique-Aguirre, Diana, additional, Peñaloza-Gonzalez, José Gabriel, additional, Baños-Lara, Ma. Del Rocío, additional, García-Soto, Ángel, additional, Galván-Díaz, César Alejandro, additional, Olaya-Vargas, Alberto, additional, Aguilar, Hilario Flores, additional, Mata-Rocha, Minerva, additional, Garrido-Hernández, Miguel Ángel, additional, Solís-Poblano, Juan Carlos, additional, Luna-Silva, Nuria Citlalli, additional, Cano-Cuapio, Lena Sarahi, additional, Aristil-Chery, Pierre Mitchel, additional, Herrera-Quezada, Fernando, additional, Carrillo-Sanchez, Karol, additional, Muñoz-Rivas, Anallely, additional, Flores-Lagunes, Luis Leonardo, additional, Mendoza-Caamal, Elvia Cristina, additional, Villegas-Torres, Beatriz Eugenia, additional, González-Osnaya, Vincent, additional, Jiménez-Hernández, Elva, additional, Torres-Nava, José Refugio, additional, Martín-Trejo, Jorge Alfonso, additional, Gutiérrez-Rivera, María de Lourdes, additional, Espinosa-Elizondo, Rosa Martha, additional, Merino-Pasaye, Laura Elizabeth, additional, Pérez-Saldívar, María Luisa, additional, Jiménez-Morales, Silvia, additional, Curiel-Quesada, Everardo, additional, Rosas-Vargas, Haydeé, additional, Mejía-Arangure, Juan Manuel, additional, and Alaez-Verson, Carmen, additional

Published
2024
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2. Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Author

Jiménez-Hernández, Elva, Duarte-Rodríguez, David Aldebarán, Núñez-Enriquez, Juan Carlos, Flores-Lujano, Janet, Martín-Trejo, Jorge Alfonso, Espinoza-Hernández, Laura Eugenia, Arellano-Galindo, José, Medina-Sanson, Aurora, García-Jiménez, Xochiketzalli, Paredes-Aguilera, Rogelio, Flores-Villegas, Luz Victoria, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Amador-Sánchez, Raquel, Dosta-Herrera, Juan José, Mondragón-García, Javier Anastacio, Valdés-Guzmán, Heriberto, Mejía-Pérez, Laura, Espinoza-Anrubio, Gilberto, Paz-Bribiesca, María Minerva, Salcedo-Lozada, Perla, Landa-García, Rodolfo Ángel, Ramírez-Colorado, Rosario, Hernández-Mora, Luis, Pérez-Saldivar, María Luisa, Santamaría-Ascencio, Marlene, López-Loyola, Anselmo, Godoy-Esquivel, Arturo Hermilo, García-López, Luis Ramiro, Anguiano-Ávalos, Alison Ireri, Mora-Rico, Karina, Castañeda-Echevarría, Alejandro, Rodríguez-Jiménez, Roberto, Cibrian-Cruz, José Alberto, Cárdenas-Cardos, Rocío, Altamirano-García, Martha Beatriz, Sánchez-Ruiz, Martin, Rivera-Luna, Roberto, Rodríguez-Villalobos, Luis Rodolfo, Hernández-Pérez, Francisco, Olvera-Durán, Jaime Ángel, García-Cortés, Luis Rey, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Bekker-Méndez, Vilma Carolina, Jiménez-Morales, Silvia, Rosas-Vargas, Haydee, and Mejía-Aranguré, Juan Manuel

Published
2020
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3. Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

Author

Duarte-Rodríguez, David Aldebarán, primary, Flores-Lujano, Janet, additional, McNally, Richard J. Q., additional, Pérez-Saldivar, María Luisa, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Medina-Sanson, Aurora, additional, Paredes-Aguilera, Rogelio, additional, Merino-Pasaye, Laura Elizabeth, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier Anastacio, additional, González-Ulibarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Paz-Bribiesca, María Minerva, additional, Salcedo-Lozada, Perla, additional, Landa-García, Rodolfo Ángel, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, Santamaría-Ascencio, Marlene, additional, López-Loyola, Anselmo, additional, Godoy-Esquivel, Arturo Hermilo, additional, García-López, Luis Ramiro, additional, Anguiano-Ávalos, Alison Ireri, additional, Mora-Rico, Karina, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Jiménez, Roberto, additional, Cibrian-Cruz, José Alberto, additional, Solís-Labastida, Karina Anastacia, additional, Cárdenas-Cardos, Rocío, additional, López-Santiago, Norma, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, González-Ávila, Ana Itamar, additional, Sánchez-Ruiz, Martin, additional, Rivera-Luna, Roberto, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Hernández-Pérez, Francisco, additional, Olvera-Durán, Jaime Ángel, additional, García-Cortés, Luis Rey, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Meléndez-Zajgla, Jorge, additional, Rosas-Vargas, Haydée, additional, Vega, Elizabeth, additional, Núñez-Enríquez, Juan Carlos, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2024
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4. A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years

Author

Mérida-Ortega, Ángel, primary, Pérez-Saldivar, María Luisa, additional, Espinoza-Hernández, Laura E., additional, Dorantes-Acosta, Elisa M., additional, Torres-Nava, José Refugio, additional, Solís-Labastida, Karina A., additional, Paredes-Aguilera, Rogelio, additional, Velázquez-Aviña, Martha M., additional, Espinosa-Elizondo, Rosa Martha, additional, Miranda-Madrazo, M. Raquel, additional, González-Ávila, Ana Itamar, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier A., additional, Castañeda-Echevarría, Alejandro, additional, López-Caballero, M. Guadalupe, additional, Martínez-Silva, Sofía I., additional, Rivera-González, Juan, additional, Hernández-Pineda, Norma Angélica, additional, Flores-Botello, Jesús, additional, Pérez-Gómez, Jessica Arleet, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Olvera-Durán, Jaime Ángel, additional, Martínez-Ríos, Annel, additional, García‐Cortés, Luis R., additional, Almeida-Hernández, Carolina, additional, Flores-Lujano, Janet, additional, Núñez-Enríquez, Juan Carlos, additional, Mata-Rocha, Minerva, additional, Rosas-Vargas, Haydeé, additional, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Morales, Silvia, additional, Mejía-Arangure, Juan Manuel, additional, and López-Carrillo, Lizbeth, additional

Published
2023
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5. Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

Author

Núñez-Enríquez, Juan Carlos, Gil-Hernández, Ana Elena, Jiménez-Hernández, Elva, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Espinoza-Hernández, Laura Eugenia, Duarte-Rodríguez, David Aldebarán, Amador-Sánchez, Raquel, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Pérez-Saldivar, María Luisa, Dorantes-Acosta, Elisa María, Cortés-Herrera, Beatriz, Solis-Labastida, Karina Anastacia, Núñez-Villegas, Nora Nancy, Velázquez-Aviña, Martha Margarita, Rangel-López, Angélica, González-Ávila, Ana Itamar, Santillán-Juárez, Jessica Denisse, García-Velázquez, Alejandra Jimena, Jiménez-Morales, Silvia, Bekker-Méndez, Vilma Carolina, Rosas-Vargas, Haydee, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Martín-Trejo, Jorge Alfonso, and Mejía-Aranguré, Juan Manuel

Published
2019
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6. Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)

Author

Sepúlveda-Robles, Omar, primary, Jiménez-Hernández, Elva, additional, Domínguez-Catzín, Victoria, additional, Gómez-Flores, Eber, additional, Martín-Trejo, Jorge Alfonso, additional, Flores-Lujano, Janet, additional, Torres-Nava, José Refugio, additional, Núñez-Enríquez, Juan Carlos, additional, De Ita, Marlon, additional, Medina-Sanson, Aurora, additional, Mata-Rocha, Minerva, additional, Morales-Castillo, Blanca Angelica, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Sánchez-Escobar, Norberto, additional, Peñaloza-Gonzalez, José Gabriel, additional, Espinosa-Elizondo, Rosa Martha, additional, Flores-Villegas, Luz Victoria, additional, Amador-Sanchez, Raquel, additional, Orozco-Ruiz, Darío, additional, Pérez-Saldívar, Maria Luisa, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Solís-Labastida, Karina Anastacia, additional, González-Ávila, Ana Itamar, additional, Santillán-Juárez, Jessica Denisse, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Rangel-López, Angélica, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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7. NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia

Author

Valenzuela-Vázquez, Lucero, primary, Nuñez-Enriquez, Juan Carlos, additional, Sánchez-Herrera, Jacqueline, additional, Medina-Sanson, Aurora, additional, Pérez-Saldivar, María Luisa, additional, Jiménez-Hernández, Elva, additional, Martiín-Trejo, Jorge Alfonso, additional, Del Campo-Martínez, María de Los Ángeles, additional, Flores-Lujano, Janet, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Félix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Solís-Labastida, Karina Anastacia, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Velázquez-Aviña, Martha Margarita, additional, Martínez-Ríos, Annel, additional, Aguilar-De los Santos, Antonio, additional, Santillán-Juárez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, García-Velázquez, Alejandra Jimena, additional, Mata-Rocha, Minerva, additional, Hernández-Echáurregui, Gabriela Alicia, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Mancilla-Herrera, Ismael, additional, Jimenez-Morales, Silvia, additional, Hidalgo-Miranda, Alfredo, additional, Martinez-Duncker, Ivan, additional, Waight, Jeremy D., additional, Hance, Kenneth W., additional, Madauss, Kevin P., additional, Mejía-Aranguré, Juan Manuel, additional, and Cruz-Munoz, Mario Ernesto, additional

Published
2022
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8. Persistently high incidence rates of childhood acute leukemias from 2010 to 2017 in Mexico City: A population study from the MIGICCL

Author

Flores-Lujano, Janet, primary, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Allende-López, Aldo, additional, Peñaloza-González, José Gabriel, additional, Pérez-Saldivar, María Luisa, additional, Medina-Sanson, Aurora, additional, Torres-Nava, José Refugio, additional, Solís-Labastida, Karina Anastacia, additional, Flores-Villegas, Luz Victoria, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Núñez-Villegas, Nora Nancy, additional, González-Ávila, Ana Itamar, additional, del Campo-Martínez, María de los Ángeles, additional, Alvarado-Ibarra, Martha, additional, Bekker-Méndez, Vilma Carolina, additional, Cárdenas-Cardos, Rocío, additional, Jiménez-Morales, Silvia, additional, Rivera-Luna, Roberto, additional, Rosas-Vargas, Haydee, additional, López-Santiago, Norma C., additional, Rangel-López, Angélica, additional, Hidalgo-Miranda, Alfredo, additional, Vega, Elizabeth, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Arellano-Galindo, José, additional, Núñez-Enríquez, Juan Carlos, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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9. Mutational Landscape of CEBPA in Mexican Pediatric Acute Myeloid Leukemia Patients: Prognostic Implications

Author

Molina Garay, Carolina, primary, Carrillo Sánchez, Karol, additional, Flores Lagunes, Luis Leonardo, additional, Jiménez Olivares, Marco, additional, Muñoz Rivas, Anallely, additional, Villegas Torres, Beatríz Eugenia, additional, Flores Aguilar, Hilario, additional, Núñez Enríquez, Juan Carlos, additional, Jiménez Hernández, Elva, additional, Bekker Méndez, Vilma Carolina, additional, Torres Nava, José Refugio, additional, Flores Lujano, Janet, additional, Martín Trejo, Jorge Alfonso, additional, Mata Rocha, Minerva, additional, Medina Sansón, Aurora, additional, Espinoza Hernández, Laura Eugenia, additional, Peñaloza Gonzalez, José Gabriel, additional, Espinosa Elizondo, Rosa Martha, additional, Flores Villegas, Luz Victoria, additional, Amador Sanchez, Raquel, additional, Pérez Saldívar, María Luisa, additional, Sepúlveda Robles, Omar Alejandro, additional, Rosas Vargas, Haydeé, additional, Jiménez Morales, Silvia, additional, Galindo Delgado, Patricia, additional, Mejía Aranguré, Juan Manuel, additional, and Alaez Verson, Carmen, additional

Published
2022
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10. Underexpression of LINC00173 in TCF3/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia

Author

May-Hau, Didier Ismael, primary, Bárcenas-López, Diego Alberto, additional, Núñez-Enríquez, Juan Carlos, additional, Bekker-Méndez, Vilma Carolina, additional, Beltrán-Anaya, Fredy Omar, additional, Jiménez-Hernández, Elva, additional, Ortíz-Maganda, Mónica Patricia, additional, Guerra-Castillo, Francisco Xavier, additional, Medina-Sanson, Aurora, additional, Flores-Lujano, Janet, additional, Martín-Trejo, Jorge Alfonso, additional, Peñaloza-González, José Gabriel, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Hernández-Echáurregui, Gabriela Alicia, additional, Espinosa-Elizondo, Rosa Martha, additional, Gutiérrez-Rivera, María de Lourdes, additional, Sanchez-Hernandez, Rodrigo, additional, Pérez-Saldívar, María Luisa, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Duarte-Rodríguez, David Aldebarán, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2022
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11. Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

Author

Mata-Rocha, Minerva, primary, Rangel-López, Angelica, additional, Jimenez-Hernandez, Elva, additional, Nuñez-Enríquez, Juan Carlos, additional, Morales-Castillo, Blanca Angélica, additional, Sánchez-Escobar, Norberto, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Pérez-Saldivar, María Luisa, additional, Flores-Lujano, Janet, additional, Duarte-Rodríguez, David Aldebarán, additional, Oviedo de Anda, Norma Angélica, additional, Romero Tlalolini, Maria de los Angeles, additional, Alaez Verson, Carmen, additional, Martín-Trejo, Jorge Alfonso, additional, Muñoz Medina, Jose Esteban, additional, Gonzalez-Bonilla, Cesar Raul, additional, Hernandez Cueto, Maria de los Angeles, additional, Bekker-Méndez, VC., additional, Jiménez-Morales, Silvia, additional, Medina-Sansón, Aurora, additional, Amador-Sánchez, Raquel, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Gutierrez-Rivera, Maria de Lourdes, additional, Velazquez-Aviña, Martha Margarita, additional, Santillan-Juarez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, Hernández Echáurregui, Gabriela Alicia, additional, Hidalgo-Miranda, Alfredo, additional, Arellano Galindo, José, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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12. Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

Author

Jiménez-Morales, Silvia, primary, Núñez-Enríquez, Juan Carlos, additional, Cruz-Islas, Jazmín, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Hernández, Elva, additional, Medina-Sanson, Aurora, additional, Olarte-Carrillo, Irma, additional, Martínez-Tovar, Adolfo, additional, Flores-Lujano, Janet, additional, Ramírez-Bello, Julian, additional, Pérez-Saldívar, María Luisa, additional, Martín-Trejo, Jorge Alfonso, additional, Pérez-Lorenzana, Héctor, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Felix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Flores-Bautista, Juan Eduardo, additional, Espinosa-Elizondo, Rosa Martha, additional, Román-Zepeda, Pedro Francisco, additional, Flores-Villegas, Luz Victoria, additional, Tamez-Gómez, Edna Liliana, additional, López-García, Víctor Hugo, additional, Lara-Ramos, José Ramón, additional, González-Ulivarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, García-López, Luis Ramiro, additional, Cruz-Ojeda, Gabriela Adriana, additional, Godoy-Esquivel, Arturo Emilio, additional, Contreras-Hernández, Iris, additional, Medina-Hernández, Abraham, additional, López-Caballero, María Guadalupe, additional, Hernández-Pineda, Norma Angélica, additional, Granados-Kraulles, Jorge, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Cortés-Reyes, Carlos, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Martínez-Ríos, Annel, additional, Aguilar-De-los-Santos, Antonio, additional, Serafin-Díaz, Berenice, additional, Gutiérrez-Rivera, María de Lourdes, additional, Merino-Pasaye, Laura Elizabeth, additional, Vargas-Alarcón, Gilberto, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2021
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13. Development and Validation of a One-Step RT-qPCR Assay for Identifying Common Fusion Gene Transcripts Associated with the Prognosis of Mexican Children with B-Lineage Acute Lymphoblastic Leukemia

Author

Mejía-Aranguré, Juan Manuel, primary, Mata-Rocha, Minerva, additional, Rangel-López, Angelica, additional, Núñez-Enríquez, Juan Carlos, additional, Jiménez-Hernández, Elva, additional, Morales-Castillo, Blanca Angélica, additional, Sánchez-Escobar, Norberto, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Pérez-Saldivar, María Luisa, additional, Flores-Lujano, Janet, additional, Duarte-Rodríguez, David Aldebarán, additional, de Anda, Norma Angélica Oviedo, additional, Verson, Carmen Alaez, additional, Martín-Trejo, Jorge Alfonso, additional, Campo-Martínez, María de Los Ángeles Del, additional, Muñoz-Medina, José Esteban, additional, González-Bonilla, César Raúl, additional, Cueto, Maria de los Angeles Hernandez, additional, Medina-Sansón, Aurora, additional, Amador-Sánchez, Raquel, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Solís-Labastida, Karina Anastacia, additional, Velázquez-Aviña, Martha Margarita, additional, Santillán-Juárez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, García-Velázquez, Alejandra Jimena, additional, Echáurregui, Gabriela Alicia Hernández, additional, and Rosas-Vargas, Haydeé, additional

Published
2021
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14. Copy Number Alterations are Associated with the Risk of Very Early Relapse in Pediatric B-lineage Acute Lymphoblastic Leukemia: A Nested Case-control MIGICCL Study

Author

Rosales-Rodríguez, Beatriz, primary, Núñez-Enríquez, Juan Carlos, additional, Velázquez-Wong, Ana Claudia, additional, González-Torres, Carolina, additional, Gaytán-Cervantes, Javier, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Campo-Martínez, María de los Ángeles del, additional, Medina-Sanson, Aurora, additional, Flores-Lujano, Janet, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Miranda-Madrazo, María Raquel, additional, Santillán-Juárez, Jessica Denise, additional, Pérez-Saldívar, María Luisa, additional, Gurrola-Silva, Alma, additional, Orozco-Ruiz, Darío, additional, Solís-Labastida, Karina Anastacia, additional, Velázquez-Aviña, Martha Margarita, additional, Duarte-Rodríguez, David Aldebarán, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Ortiz-Maganda, Mónica, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Mejía-Aranguré, Juan Manuel, additional, and Rosas-Vargas, Haydeé, additional

Published
2021
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15. Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Author

Medina-Sanson, Aurora, primary, Núñez-Enríquez, Juan Carlos, additional, Hurtado-Cordova, Eduardo, additional, Pérez-Saldivar, María Luisa, additional, Martínez-García, Anayeli, additional, Jiménez-Hernández, Elva, additional, Fernández-López, Juan Carlos, additional, Martín-Trejo, Jorge Alfonso, additional, Pérez-Lorenzana, Héctor, additional, Flores-Lujano, Janet, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Felix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Flores-Bautista, Juan Eduardo, additional, Espinosa-Elizondo, Rosa Martha, additional, Román-Zepeda, Pedro Francisco, additional, Flores-Villegas, Luz Victoria, additional, González-Ulivarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, García-López, Luis Ramiro, additional, Cruz-Ojeda, Gabriela Adriana, additional, Godoy-Esquivel, Arturo Emilio, additional, Contreras-Hernández, Iris, additional, Medina-Hernández, Abraham, additional, López-Caballero, María Guadalupe, additional, Hernández-Pineda, Norma Angélica, additional, Granados-Kraulles, Jorge, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Cortés-Reyes, Carlos, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Martínez-Ríos, Annel, additional, Aguilar-De los Santos, Antonio, additional, Serafin-Díaz, Berenice, additional, Bekker-Méndez, Vilma Carolina, additional, Mata-Rocha, Minerva, additional, Morales-Castillo, Blanca Angélica, additional, Sepúlveda-Robles, Omar Alejandro, additional, Ramírez-Bello, Julián, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2020
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16. Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival

Author

Molina Garay, Carolina, primary, Carrillo Sánchez, Karol, additional, Flores Lagunes, Luis Leonardo, additional, Jiménez Olivares, Marco, additional, Muñoz Rivas, Anallely, additional, Villegas Torres, Beatríz Eugenia, additional, Flores Aguilar, Hilario, additional, Núñez Enríquez, Juan Carlos, additional, Jiménez Hernández, Elva, additional, Bekker Méndez, Vilma Carolina, additional, Torres Nava, José Refugio, additional, Flores Lujano, Janet, additional, Martín Trejo, Jorge Alfonso, additional, Mata Rocha, Minerva, additional, Medina Sansón, Aurora, additional, Espinoza Hernández, Laura Eugenia, additional, Peñaloza Gonzalez, José Gabriel, additional, Espinosa Elizondo, Rosa Martha, additional, Flores Villegas, Luz Victoria, additional, Amador Sanchez, Raquel, additional, Pérez Saldívar, Maria Luisa, additional, Sepúlveda Robles, Omar Alejandro, additional, Rosas Vargas, Haydeé, additional, Rangel López, Angélica, additional, Domínguez López, María Lilia, additional, García Latorre, Ethel Awilda, additional, Reyes Maldonado, Elba, additional, Galindo Delgado, Patricia, additional, Mejía Aranguré, Juan Manuel, additional, and Alaez Verson, Carmen, additional

Published
2020
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17. Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia

Author

Bárcenas-López, Diego Alberto, primary, Núñez-Enríquez, Juan Carlos, additional, Hidalgo-Miranda, Alfredo, additional, Beltrán-Anaya, Fredy Omar, additional, May-Hau, Didier Ismael, additional, Jiménez-Hernández, Elva, additional, Bekker-Méndez, Vilma Carolina, additional, Flores-Lujano, Janet, additional, Medina-Sansón, Aurora, additional, Tamez-Gómez, Edna Liliana, additional, López-García, Víctor Hugo, additional, Lara-Ramos, José Ramón, additional, Núñez-Villegas, Nora Nancy, additional, Peñaloza-González, José Gabriel, additional, Flores-Villegas, Luz Victoria, additional, Amador-Sánchez, Raquel, additional, Espinosa-Elizondo, Rosa Martha, additional, Martín-Trejo, Jorge Alfonso, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Pérez-Saldívar, María Luisa, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Cortés-Herrera, Beatriz, additional, Solís-Labastida, Karina Anastacia, additional, González-Ávila, Ana Itamar, additional, Santillán-Juárez, Jessica Denisse, additional, García-Velázquez, Alejandra Jimena, additional, Rosas-Vargas, Haydee, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2020
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18. Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Author

Valenzuela-Vazquez, Lucero, primary, Núñez-Enríquez, Juan Carlos, additional, Sánchez-Herrera, Jacqueline, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Medina-Sanson, Aurora, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, Refugio Torres-Nava, José, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Santillán-Juárez, Jessica Denisse, additional, Flores-Lujano, Janet, additional, Pérez-Saldívar, María Luisa, additional, García-López, Luis Ramiro, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Leyva, Francisco, additional, Rosas-Vargas, Haydeé, additional, Mata-Rocha, Minerva, additional, Duarte-Rodríguez, David Aldebarán, additional, Sepúlveda-Robles, Omar Alejandro, additional, Mancilla-Herrera, Ismael, additional, Mejía-Aranguré, Juan Manuel, additional, and Cruz-Munoz, Mario Ernesto, additional

Published
2020
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19. Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Author

Mata-Rocha, Minerva, primary, Rangel-López, Angelica, additional, Jiménez-Hernández, Elva, additional, Morales-Castillo, Blanca Angélica, additional, González-Torres, Carolina, additional, Gaytan-Cervantes, Javier, additional, Álvarez-Olmos, Enrique, additional, Núñez-Enríquez, Juan Carlos, additional, Fajardo-Gutiérrez, Arturo, additional, Martín-Trejo, Jorge Alfonso, additional, Solís-Labastida, Karina Anastacia, additional, Medina-Sansón, Aurora, additional, Flores-Lujano, Janet, additional, Sepúlveda-Robles, Omar Alejandro, additional, Peñaloza-González, José Gabriel, additional, Espinoza-Hernández, Laura Eugenia, additional, Núñez-Villegas, Nora Nancy, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Torres-Nava, José Refugio, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Bekker-Méndez, Vilma Carolina, additional, Velázquez-Aviña, Martha Margarita, additional, Pérez-Saldívar, María Luisa, additional, Bautista-Martínez, Benito Alejandro, additional, Amador-Sánchez, Raquel, additional, González-Avila, Ana Itamar, additional, Jiménez-Morales, Silvia, additional, Duarte-Rodríguez, David Aldebarán, additional, Santillán-Juárez, Jessica Denisse, additional, García-Velázquez, Alejandra Jimena, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2019
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20. A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)

Author

Jiménez-Hernández, Elva, primary, Fajardo-Gutiérrez, Arturo, additional, Núñez-Enriquez, Juan Carlos, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Flores-Lujano, Janet, additional, Arellano-Galindo, José, additional, Medina-Sanson, Aurora, additional, Paredes-Aguilera, Rogelio, additional, Merino-Pasaye, Laura Elizabeth, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier Anastacio, additional, Valdés-Guzmán, Heriberto, additional, Mejía-Pérez, Laura, additional, Espinoza-Anrubio, Gilberto, additional, Paz-Bribiesca, María Minerva, additional, Salcedo-Lozada, Perla, additional, Landa-García, Rodolfo Ángel, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, Pérez-Saldivar, María Luisa, additional, Santamaría-Ascencio, Marlene, additional, López-Loyola, Anselmo, additional, Godoy-Esquivel, Arturo Hermilo, additional, García-López, Luis Ramiro, additional, Anguiano-Ávalos, Alison Ireri, additional, Mora-Rico, Karina, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Jiménez, Roberto, additional, Cibrian-Cruz, José Alberto, additional, Solís-Labastida, Karina Anastacia, additional, Cárdenas-Cardos, Rocío, additional, Martínez-Avalos, Armando, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, González-Ávila, Ana Itamar, additional, Altamirano-García, Martha Beatriz, additional, López-Santiago, Norma, additional, Sánchez-Ruiz, Martin, additional, Rivera-Luna, Roberto, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Hernández-Pérez, Francisco, additional, Olvera-Durán, Jaime Ángel, additional, García-Cortés, Luis Rey, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, González-Bonilla, Cesar Raúl, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Rosas-Vargas, Haydee, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2018
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21. Copy Number Alterations Associated with Acute Lymphoblastic Leukemia in Mexican Children. A report from The Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

Author

Rosales-Rodríguez, Beatriz, primary, Fernández-Ramírez, Fernando, additional, Núñez-Enríquez, Juan Carlos, additional, Velázquez-Wong, Ana Claudia, additional, Medina-Sansón, Aurora, additional, Jiménez-Hernández, Elva, additional, Flores-Lujano, Janet, additional, Peñaloza-González, José Gabriel, additional, Espinosa-Elizondo, Rosa Martha, additional, Pérez-Saldívar, María Luisa, additional, Torres-Nava, José Refugio, additional, Martín-Trejo, Jorge Alfonso, additional, Martínez-Morales, Gabriela Bibiana, additional, Bekker-Méndez, Vilma Carolina, additional, Mejía-Aranguré, Juan Manuel, additional, and Rosas-Vargas, Haydee, additional

Published
2016
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22. Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study

Author

Martín-Trejo, Jorge Alfonso, primary, Núñez-Enríquez, Juan Carlos, additional, Fajardo-Gutiérrez, Arturo, additional, Medina-Sansón, Aurora, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, Amador-Sanchez, Raquel, additional, Peñaloza-Gonzalez, José Gabriel, additional, Alvarez-Rodriguez, Francisco Javier, additional, Bolea-Murga, Victoria, additional, Espinosa-Elizondo, Rosa Martha, additional, de Diego Flores-Chapa, José, additional, Pérez-Saldivar, Maria Luisa, additional, Rodriguez-Zepeda, María del Carmen, additional, Dorantes-Acosta, Elisa María, additional, Núñez-Villegas, Nora Nancy, additional, Velazquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Reyes-Zepeda, Nancy Carolina, additional, González-Bonilla, César Raúl, additional, Flores-Villegas, Luz Victoria, additional, Rangel-López, Angélica, additional, Rivera-Luna, Roberto, additional, Paredes-Aguilera, Rogelio, additional, Cárdenas-Cardós, Rocío, additional, Martínez-Avalos, Armando, additional, Gil-Hernández, Ana Elena, additional, Duarte-Rodríguez, David Aldebarán, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2016
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23. Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study.

Author

Martín-Trejo, Jorge Alfonso, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Jiménez-Hernández, Elva, Amador-Sanchez, Raquel, Peñaloza-Gonzalez, José Gabriel, Alvarez-Rodriguez, Francisco Javier, Bolea-Murga, Victoria, Espinosa-Elizondo, Rosa Martha, de Diego Flores-Chapa, José, Pérez-Saldivar, Maria Luisa, Rodriguez-Zepeda, María del Carmen, Dorantes-Acosta, Elisa María, Núñez-Villegas, Nora Nancy, Velazquez-Aviña, Martha Margarita, Torres-Nava, José Refugio, Reyes-Zepeda, Nancy Carolina, and González-Bonilla, César Raúl

Subjects
LYMPHOBLASTIC leukemia in children, LEUKEMIA in children, MALNUTRITION diagnosis, NUTRITION disorders in children, CHILDREN'S health, DIAGNOSIS, LEUKEMIA treatment
Abstract

The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient’s age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08–4.01) was observed in the group of malnourished children with a high-risk ALL. [ABSTRACT FROM AUTHOR]

Published
2017
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24. Lack of Evidence for Human T-Lymphotropic Virus Type 1 and Mouse Mammary Tumor–Like Virus Involvement in the Genesis of Childhood Acute Lymphoblastic Leukemia

Author

Morales-Sánchez, Abigail, primary, Bernáldez-Ríos, Roberto, additional, Álvarez-Rodríguez, Francisco Javier, additional, Bekker-Méndez, Vilma Carolina, additional, Fajardo-Gutiérrez, Arturo, additional, de Diego Flores-Chapa, José, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, Peñaloza-González, José Gabriel, additional, del Carmen Rodríguez-Zepeda, María, additional, Torres-Nava, José Refugio, additional, Velázquez-Aviña, Martha Margarita, additional, Amador-Sánchez, Raquel, additional, Alvarado-Ibarra, Martha, additional, Reyes-Zepeda, Nancy, additional, Espinosa-Elizondo, Rosa Martha, additional, Fuentes-Pananá, Ezequiel M., additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2013
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25. Screening for Retrovirus Genomes in Childhood Acute Lymphoblastic Leukemia

Author

Morales-Sánchez, Abigail, primary, Mejia-Arangure, Juan Manuel, additional, Bernáldez-Ríos, Roberto, additional, Álvarez-Rodríguez, Francisco Javier, additional, Bekker-Méndez, Vilma Carolina, additional, Fajardo-Gutiérrez, Arturo, additional, Dorantes-Acosta, Elisa, additional, Duarte-Rodríguez, David Aldebarán, additional, Flores-Chapa, José de Diego, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, Medina-Sanson, Aurora, additional, Peñaloza-González, José Gabriel, additional, Rodríguez-Zepeda, María del Carmen, additional, Nava, José-Refugio Torres, additional, Velázquez-Aviña, Martha Margarita, additional, Amador-Sánchez, Raquel, additional, Alvarado-Ibarra, Martha, additional, Reyes-Zepeda, Nancy, additional, Bolea-Murga, Victoria, additional, Espinosa-Elizondo, Rosa Martha, additional, and Fuentes-Pananá, Ezequiel M, additional

Published
2012
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26. Detección de infección asintomática por citomegalovirus en donadores voluntarios de sangre.

Author

Gutiérrez-Salinas, José, Carmona-García, Rosalba, García-Ortiz, Liliana, del Carmen Chima-Galán, María, Suástegui-Domínguez, Sigrit, Espinosa-Elizondo, Rosa Martha, de Jesús Treviño-Mejia, Alberto, García-Méndez, Sergio, and Rivera-Badillo, Martha Elena

Subjects
CYTOMEGALOVIRUS diseases, ENZYME-linked immunosorbent assay, ORGAN donation, BLOOD donors, DNA
Abstract

Copyright of Medicina Interna de Mexico is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010

27. IKZF1 plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia.

Author

Garcia-Solorio J, Núñez-Enriquez JC, Jiménez-Olivares M, Flores-Lujano J, Flores-Espino F, Molina-Garay C, Cervera A, Casique-Aguirre D, Peñaloza-Gonzalez JG, Baños-Lara MDR, García-Soto Á, Galván-Díaz CA, Olaya-Vargas A, Aguilar HF, Mata-Rocha M, Garrido-Hernández MÁ, Solís-Poblano JC, Luna-Silva NC, Cano-Cuapio LS, Aristil-Chery PM, Herrera-Quezada F, Carrillo-Sanchez K, Muñoz-Rivas A, Flores-Lagunes LL, Mendoza-Caamal EC, Villegas-Torres BE, González-Osnaya V, Jiménez-Hernández E, Torres-Nava JR, Martín-Trejo JA, Gutiérrez-Rivera ML, Espinosa-Elizondo RM, Merino-Pasaye LE, Pérez-Saldívar ML, Jiménez-Morales S, Curiel-Quesada E, Rosas-Vargas H, Mejía-Arangure JM, and Alaez-Verson C

Abstract

Background: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. IKZF1 plus is a complex biomarker associated with a poor prognosis. It is characterized by IKZF1 deletion coexisting with PAX5 , CDKN2A/2B , or PAR1 region deletions. The mutational spectrum and clinical impact of these alterations have scarcely been explored in Mexican pediatric patients with B-ALL. Here, we report the frequency of the IKZF1 plus profile and the mutational spectrum of IKZF1, PAX5, CDKN2A/2B , and ERG genes and evaluate their impact on overall survival (OS) in a group of patients with B-ALL., Methods: A total of 206 pediatric patients with de novo B-ALL were included. DNA was obtained from bone marrow samples at diagnosis before treatment initiation. A custom-designed next-generation sequencing panel was used for mutational analysis. Kaplan-Meier analysis was used for OS estimation., Results: We identified the IKZF1 plus profile in 21.8% of patients, which was higher than that previously reported in other studies. A significantly older age ( p=0.04 ), a trend toward high-risk stratification ( p=0.06 ), and a decrease in 5-year Overall Survival (OS) ( p=0.009 ) were observed, although heterogeneous treatment protocols in our cohort would have impacted OS. A mutation frequency higher than that reported was found for IKZF1 (35.9%) and CDKN2A/2B (35.9%) but lower for PAX5 (26.6%). IKZF1 MUT group was older at diagnosis ( p=0.0002 ), and most of them were classified as high-risk (73.8%, p=0.02 ), while patients with CDKN2A/2B MUT had a higher leukocyte count ( p=0.01 ) and a tendency toward a higher percentage of blasts (98.6%, >50% blasts, p=0.05 ) than the non-mutated patients. A decrease in OS was found in IKZF1 MUT and CDKN2A/2B MUT patients, but the significance was lost after IKZF1 plus was removed., Discussion: Our findings demonstrated that Mexican patients with B-ALL have a higher prevalence of genetic markers associated with poor outcomes. Incorporating genomic methodologies into the diagnostic process, a significant unmet need in low- and mid-income countries, will allow a comprehensive identification of relevant alterations, improving disease classification, treatment selection, and the general outcome., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer, AM, declared a shared affiliation with the author RE-E to the handling editor at the time of review., (Copyright © 2024 Garcia-Solorio, Núñez-Enriquez, Jiménez-Olivares, Flores-Lujano, Flores-Espino, Molina-Garay, Cervera, Casique-Aguirre, Peñaloza-Gonzalez, Baños-Lara, García-Soto, Galván-Díaz, Olaya-Vargas, Aguilar, Mata-Rocha, Garrido-Hernández, Solís-Poblano, Luna-Silva, Cano-Cuapio, Aristil-Chery, Herrera-Quezada, Carrillo-Sanchez, Muñoz-Rivas, Flores-Lagunes, Mendoza-Caamal, Villegas-Torres, González-Osnaya, Jiménez-Hernández, Torres-Nava, Martín-Trejo, Gutiérrez-Rivera, Espinosa-Elizondo, Merino-Pasaye, Pérez-Saldívar, Jiménez-Morales, Curiel-Quesada, Rosas-Vargas, Mejía-Arangure and Alaez-Verson.)

Published
2024
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28. Analytical study of RUNX1-RUNXT1 , PML-RARA , CBFB-MYH11 , BCR-ABL1 p210 , and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL).

Author

Sepúlveda-Robles O, Jiménez-Hernández E, Domínguez-Catzín V, Gómez-Flores E, Martín-Trejo JA, Flores-Lujano J, Torres-Nava JR, Núñez-Enríquez JC, De Ita M, Medina-Sanson A, Mata-Rocha M, Morales-Castillo BA, Bravata-Alcántara JC, Nájera-Cortés AS, Sánchez-Escobar N, Peñaloza-Gonzalez JG, Espinosa-Elizondo RM, Flores-Villegas LV, Amador-Sanchez R, Orozco-Ruiz D, Pérez-Saldívar ML, Velázquez-Aviña MM, Merino-Pasaye LE, Solís-Labastida KA, González-Ávila AI, Santillán-Juárez JD, Bekker-Méndez VC, Jiménez-Morales S, Rangel-López A, Rosas-Vargas H, and Mejía-Aranguré JM

Abstract

Background: The distribution of RUNX1-RUNXT1 , PML-RARA , CBFB-MYH11 , BCR-ABL1 p210 , and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment., Methods: We retrospectively analyzed the presence of RUNX1-RUNXT1 , PML-RARA , CBFB-MYH11 , BCR-ABL1 p210 , and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals., Results: The overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1 p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML., Conclusion: The pediatric population of Mexico City with AML had frequencies of AML1-ETO , PML-RARA , CBFB-MYH11 , and BCR-ABL1 p210 similar to those of other populations around the world. Patients with BCR-ABL1 p210 and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Sepúlveda-Robles, Jiménez-Hernández, Domínguez-Catzín, Gómez-Flores, Martín-Trejo, Flores-Lujano, Torres-Nava, Núñez-Enríquez, De Ita, Medina Sanson, Mata-Rocha, Morales-Castillo, Bravata-Alcántara, Nájera-Cortés, Sánchez-Escobar, Peñaloza-Gonzalez, Espinosa-Elizondo, Flores-Villegas, Amador-Sánchez, Orozco-Ruiz, Pérez-Saldívar, Velázquez-Aviña, Merino-Pasaye, Solís-Labastida, González-Ávila, Santillán-Juárez, Bekker-Méndez, Jiménez-Morales, Rangel-López, Rosas-Vargas and Mejía-Aranguré.)

Published
2022
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29. [Descriptive epidemiology of children with acute myeloid leukemia residing in Mexico City: a report from the Mexican Inter-Institutional Group for Identifying Childhood Leukemia Causes].

Author

Mejía-Aranguré JM, Núñez-Enríquez JC, Fajardo-Gutiérrez A, Rodríguez-Zepeda MD, Martín-Trejo JA, Duarte-Rodríguez DA, Medina-Sansón A, Flores-Lujano J, Jiménez-Hernández E, Núñez-Villegas NN, Pérez-Saldívar ML, Paredes-Aguilera R, Cárdenas-Cardós R, Flores-Chapa JD, Reyes-Zepeda NC, Flores-Villegas LV, Amador-Sánchez R, Torres-Nava JR, Bolea-Murga V, Espinosa-Elizondo RM, Peñaloza-González JG, Velázquez-Aviña MM, González-Bonilla C, Békker-Méndez VC, Jiménez-Morales S, Martínez-Morales GB, Vargas HR, and Rangel-López A

Subjects
Adolescent, Child, Cities epidemiology, Humans, Incidence, Infant, Leukemia, Myeloid, Acute etiology, Male, Mexico epidemiology, Risk Factors, Sex Distribution, Leukemia, Myeloid, Acute epidemiology
Abstract

Introduction: Acute myeloid leukemias represent the second most common childhood leukemia subtype. In Mexico, there are few studies on descriptive epidemiology for this disease., Aims: To report acute myeloid leukemia incidence for children less than 15 years of age in the Metropolitan Area of the Valley of Mexico for a period of five years (2010-2014) and to analyze whether there are differences in the incidence of acute myeloid leukemia by regions., Material and Methods: A descriptive study was conducted in nine public hospitals in Mexico City. The crude annual average incidence rate and adjusted average annual incidence rate were calculated., Results: A total of 190 patients with diagnosis of de novo acute myeloid leukemia were analyzed. Male sex (57.2%) and acute myeloid leukemia-M3 subtype (25.3%) were more frequent. The adjusted average annual incidence rates for Mexico City and for the Metropolitan Area of the Valley of Mexico were 8.18 and 7.74 per million children under 15 years old, respectively., Conclusions: It seems that childhood acute myeloid leukemia incidence is increasing in Mexico City, which makes the identification of associated risk factors imperative.

Published
2016

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