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6. Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies

Author

Carrillo-Larco, Rodrigo M., Stern, Dalia, Hambleton, Ian R., Hennis, Anselm, Cesare, Mariachiara Di, Lotufo, Paulo, Ferreccio, Catterina, Irazola, Vilma, Perel, Pablo, Gregg, Edward W, Miranda, J. Jaime, Ezzati, Majid, Danaei, Goodarz, Aguilar-Salinas, Carlos A, Alvarez-Váz, Ramón, Amadio, Marselle B, Baccino, Cecilia, Bambs, Claudia, Bastos, João Luiz, Beckles, Gloria, Bernabe-Ortiz, Antonio, Bernardo, Carla DO, Bloch, Katia V., Blümel, Juan E., Boggia, Jose G., Borges, Pollyanna K., Bravo, Miguel, Brenes-Camacho, Gilbert, Carbajal, Horacio A, Rascon, Maria S. Castillo, Ceballos, Blanca H., Colpani, Veronica, Cooper, Jackie A, Cortes, Sandra, Cortes-Valencia, Adrian, Cunha, Roberto S, d'Orsi, Eleonora, Dow, William H, Espeche, Walter G, Fuchs, Flavio D., Fuchs, Sandra C., Gimeno, Suely GA, Gomez-Velasco, Donaji, Gonzalez-Chica, David A, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, María-Elena, Grazioli, Gonzalo, Guerra, Ricardo O., Gutierrez, Laura, Herkenhoff, Fernando L, Horimoto, Andrea RVR, Huidobro, Andrea, Koch, Elard, Lajous, Martin, Lima-Costa, Maria Fernanda, Lopez-Ridaura, Ruy, Maciel, Alvaro CC, Manrique-Espinoza, Betty S, Marques, Larissa P, Mill, Jose G, Moreira, Leila B, Muñoz, Oscar M, Ono, Lariane M, Oppermann, Karen, Paiva, Karina M., Peixoto, Sergio V., Pereira, Alexandre C., Peres, Karen G., Peres, Marco A., Ramírez-Palacios, Paula, Rech, Cassiano R, Rivera-Paredez, Berenice, Rodriguez, Nohora I, Rojas-Martinez, Rosalba, Rosero-Bixby, Luis, Rubinstein, Adolfo, Ruiz-Morales, Alvaro, Salazar, Martin R, Salinas-Rodriguez, Aaron, Salmerón, Jorge, Sanchez, Ramon A, Silva, Nelson AS, Silva, Thiago LN, Smeeth, Liam, Spritzer, Poli M, Tartaglione, Fiorella, Tartaglione, Jorge, and Velázquez-Cruz, Rafael

Published
2021
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13. Desarrollo de un modelo por inteligencia artificial con hemodinamia no invasiva para predecir preeclampsia en embarazos de alto riesgo.

Author

OLANO, RICARDO D., ESPECHE, WALTER G., SISNIEGUEZ, BETTY C. LEIVA, RAMOS, PATRICIA M. CARRERA, MARTINEZ, CAMILO, SISNIEGUEZ, CARLOS E. LEIVA, DE IRAOLA, ANA, GOMEZ, DANIELA R., MINETTO, JULIÁN, and SALAZAR, MARTÍN R.

Subjects
AMBULATORY blood pressure monitoring, PULSE wave analysis, HELLP syndrome, PREGNANT women, RECEIVER operating characteristic curves
Abstract

Copyright of Revista Argentina de Cardiología is the property of Sociedad Argentina de Cardiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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14. Hypertension arising after 20 weeks of gestation: gestational hypertension or masked chronic hypertension?

Author

Espeche, Walter G., primary, Salazar, Martin R., additional, Minetto, Julián, additional, Leiva Sisnieguez, Carlos E., additional, Cerri, Gustavo, additional, Balbín, Eduardo, additional, Stavile, Rodolfo N., additional, Carrera Ramos, Patricia, additional, Soria, Adelaida, additional, Santillan, Claudia, additional, Grassi, Florencia, additional, Torres, Soledad, additional, and Carbajal, Horacio A., additional

Published
2022
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19. Masked hypertension and neonatal outcome in high-risk pregnancies

Author

Salazar, Martin R., primary, Espeche, Walter G., additional, Leiva sisnieguez, Carlos E., additional, Juliano, Paola L., additional, Vulcano, María V., additional, Sanchez caro, Laura, additional, Minetto, Julián, additional, Balbín, Eduardo, additional, and Carbajal, Horacio A., additional

Published
2022
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20. Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis

Author

Gagliardino, Juan J., primary, Salazar, Martin R., additional, Espeche, Walter G., additional, Tolosa Chapasian, Paula E., additional, Gomez Garizoain, Daniela, additional, Olano, Ricardo D., additional, Stavile, Rodolfo N., additional, Balbín, Eduardo, additional, Martinez, Camilo, additional, Leiva Sisnieguez, Betty C., additional, Leiva Sisnieguez, Carlos E., additional, and Carbajal, Horacio A., additional

Published
2021
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22. May Measurement Month 2019: an analysis of blood pressure screening results from Argentina

Author

Salazar, Martin R, primary, Garcia Vazquez, Fortunato, additional, Espeche, Walter G, additional, Marquez, Diego, additional, Becerra, Pedro, additional, Martinez Marissi, Evangelina, additional, Sorasio, Viviana B, additional, Staffieri, Gustavo J, additional, Kalbermatter, Arnoldo, additional, De Cerchio, Alejandro E, additional, Beaney, Thomas, additional, Partington, Giles, additional, Poulter, Neil R, additional, Marín, Marcos J, additional, and Ennis, Irene L, additional

Published
2021
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23. Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age.

Author

Sala, Marisa E., Romero, M. Florencia, Romero, Anabella, Fasano, M. Victoria, Varea, Ana M., Carrera, Patricia, Salazar, Martín R., Espeche, Walter G., and González, Horacio F.

Subjects
PREGNANCY complications, NEURAL development, INFANT growth, MATERNAL mortality, OBSTETRICAL emergencies
Abstract

Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas "Prof. Dr. Fernando E. Viteri" during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student's t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age. [ABSTRACT FROM AUTHOR]

Published
2022
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24. May Measurement Month 2018: an analysis of blood pressure screening results from Argentinean cohort

Author

Espeche, Walter G, primary, Rojas, Cristina, additional, Stisman, Diego, additional, Fuentes, Analia, additional, Fita, Mariana, additional, Lacunza, Carlos Diego, additional, Marquez, Diego, additional, Grosse, Pedro, additional, Bueno, Dennis, additional, Zilberman, Judith, additional, Beaney, Thomas, additional, Ster, Anca Chis, additional, Poulter, Neil R, additional, Marín, Marcos, additional, and Ennis, Irene L, additional

Published
2020
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26. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Author

Beaney, Thomas, Burrell, Louise M, Castillo, Rafael R, Charchar, Fadi J, Cro, Suzie, Damasceno, Albertino, Kruger, Ruan, Nilsson, Peter M, Prabhakaran, Dorairaj, Ramirez, Agustin J, Schlaich, Markus P, Schutte, Aletta E, Tomaszewski, Maciej, Touyz, Rhian, Wang, Ji-Guang, Weber, Michael A, Poulter, Neil R, Burazeri, Genc, Qirjako, Gentiana, Roshi, Enver, Cunashi, Rudina, Fernandes, Mario J C C, Victória Pereira, Savarino S, Neto, Marisa F M P, Oliveira, Pombalino N M, Feijão, Ana C G, Cerniello, Yamila, Marin, Marcos J, Garcia Vasquez, Fortunato, Espeche, Walter G, Stisman, Diego, Fuentes, Inés A, Zilberman, Juith M, Rodriguez, Pablo, Babinyan, Kamsar Yu, Engibaryan, Anna H, Avagyan, Avag M, Minasyan, Arsen A, Gevorkyan, Ani T, Carnagarin, Revathy, Carrington, Melinda J, Sharman, James E, Lee, Rebecca, Perl, Sabine, Niederl, Ella, Malik, Fazila-Tun-Nesa, Choudhury, Sohel R, Al Mamun, Mohammad A, Ishraquzzaman, Mir, Anthony, Fiona, Connell, Kenneth, De Backer, Tine L M, Krzesinski, Jea, Houenassi, Martin D, Houehanou, Corine Y, Sokolovic, Sekib, Bahtijarevic, Rankica, Tiro, Mary B, Mosepele, Mosepele, Masupe, Tiny K, Barroso, Weimar S, Gomes, Marco A M, Feitosa, Audes D M, Brandão, Andrea A, Miranda, Roberto D, Azevedo, Vanda M A A, Dias, Luis M, Garcia, Glenda D N, Martins, Idiana P P, Dzudie, Anastase, Kingue, Samuel, Djomou, Florent A N, Njume, Epie, Khan, Nadia, Lanas, Fernando T, Garcia, Maria S, Paccot, Melanie F, Torres, Pamela I, Li, Yan, Liu, Min, Xu, Liying, Li, Li, Chen, Xin, Deng, Junping, Zhao, Wenwu, Fu, Lingjuan, Zhou, Yi, Lopez-Jaramillo, Patricio, Otero, Johanna, Camacho, Paul A, Accini, Jose L, Sanchez, Gregorio, Arcos, Edgar, M’Buyamba-Kabangu, Jean-René, Katamba, Fortunat K, Ngoyi, Georges N, Buila, Nathan M, Bayauli, Pascal M, Ellenga Mbolla, Bertrand F, Bakekolo, Paterne R, Kouala Landa, Christian M, Kimbally Kaky, Gisele S, Kramoh, Euloge K, Ngoran, Yves N K, Olsen, Michael H, Valdez Valoy, Laura, Santillan, Marcos, Angel Rafael, Gonzalez Medina, Peñaherrera, Carlos E, Villalba, Jose, Ramirez, Maria I, Arteaga, Fabricio, Delgado, Patricia, Beistline, Holly, Cappuccio, Francesco P, Keitley, James, Tay, Tricia, Goshu, Dejuma Y, Kassie, Desalew M, Gebru, Sintayehu A, Pathak, Atul, Denolle, Thierry, Tsinamdzgvrishvili, Bezhan, Trapaidze, Dali, Sturua, Lela, Abesadze, Tamar, Grdzelidze, Nino, Grabfelder, Mark, Krämer, Bernhard K, Schmeider, Roland E, Twumasi-Ankrah, Betty, Tannor, Elliot K, Lincoln, Mary D, Deku, Enoch M, Wyss Quintana, Fernando S, Kenerson, John, Jean Baptiste, Emmanuela D, Saintilmond, Wideline W, Barrientos, Ana L, Peiger, Briggitte, Lagos, Ashley R, Forgas, Marcelo A, Lee, Vivian W Y, Tomlinson, Brian W Y, Járai, Zoltán, Páll, Dénes, More, Arun, Maheshwari, Anuj, Verma, Narsingh, Sharma, Meenakshi, Mukherjee, Tapan K, Patil, Mansi, Pulikkottil Jose, Arun, Takalkar, Anant, Turana, Yuda, Widyantoro, Bambang, Danny, Siska S, Djono, Suhar, Handari, Saskia D, Tambunan, Marihot, Tiksnadi, Badai B, Hermiawaty, Eka, Tavassoli, Elham, Zolfaghari, Mahsa, Dolan, Eamon, O'Brien, Eoin, Borghi, Claudio, Ferri, Claudio, Torlasco, Camilla, Parati, Gianfranco, Nwokocha, Chukwuemeka R, Nwokocha, Magdalene I, Ogola, Elijah N, Gitura, Bernard M, Barasa, Anders L, Barasa, Felix A, Wairagu, Anne W, Nalwa, Wafula Z, Najem, Robert N, Abu Alfa, Ali K, Fageh, Hatem A, Msalam, Omar M, Derbi, Hawa A, Bettamar, Kzaki A, Zakauskiene, Urte, Vickiene, Alvita, Calmes, Jessica, Alkerwi, Ala'a, Gantenbein, Manon, Ndhlovu, Henry L L, Masiye, Jones K, Chirwa, Maureen L, Nyirenda, Nancy M, Dhlamini, Tiyezge D, Chia, Yook C, Ching, Siew M, Devaraj, Navin K, Ouane, Nouhoum, Fane, Tidiani, Kowlessur, Sudhir, Ori, Bhooshun, Heecharan, Jaysing, Alcocer, Luis, Chavez, Adolfo, Ruiz, Griselda, Espinosa, Cutberto, Gomez-Alvarez, Enrique, Neupane, Dinesh, Bhattarai, Harikrishna, Ranabhat, Kamal, Adhikari, Tara B, Koirala, Sweta, Toure, Ibrahim A, Soumana, Kabirou H, Wahab, Kolawole W, Omotoso, Ayodele B, Sani, Mahmoud U, Okubadejo, Njideka U, Nadar, Sunil K, Al-Riyami, Hassan A, Ishaq, Mohammad, Memon, Feroz, Sidique, Sualat, Choudhry, Hafeez A, Khan, Rasheed A, Ayala, Myrian, Maidana, Angel J O, Bogado, Graciela GG, Ona, Deborah I, Atilano, Alberto, Granada, Carmela, Bartolome, Regina, Manese, Loudes, Mina, Arnold, Dumlao, Maria C, Villaruel, Mariyln C, Gomez, lynn, Jóźwiak, Jacek, Małyszko, Jolanta, Banach, Maciej, Mastej, Mirosław, de Carvalho Rodrigues, Manuel M, Martins, Luis L, Paval, Alexandra, Dorobantu, Maria, Konradi, Alexandra O, Chazova, Irina E, Rotar, Oxana, Spoares, Miryan C, Viegas, Deolsanik, Almustafa, Bader A, Alshurafa, Saleh A, Brady, Adrian, Bovet, Pascal, Viswanathan, Bharathi, Oladapo, Olulola O, Russell, James W, Brguljan-Hitij, Jana, Bozic, Nina, Knez, Judita, Dolenc, Primoz, Hassan, Mohammed M, Woodiwiss, Angela J, Myburgh, Caitlynd, Vally, Muhammed, Ruilope, Luis M, Molinero, Ana, Rodilla, Enrique, Gijón-Conde, Teresa, Beheiry, Hind M, Ali, I A, Osman, Asma A A, fahal, Naiema A W, Osman, Hana A, Altahir, Fatima, Persson, Margaretha, Wuerzner, Gregoire, Burkard, Thilo, Wang, Tzung-Dau, Lin, Hung-Ju, Pan, Heng-Yu, Chen, Wen-Jone, Lin, Eric, Mondo, Charles K, Ingabire, Prossie M, Khomazyuk, Tatyana TA, Krotova, Viktoriia V-Yu, Negresku, Elena, Evstigneeva, Olena, Bazargani, Nooshin NB, Agrawal, Amrish, Bin Belaila, Buthaina A, Suhail, Aisha M, Muhammed, Khalifa O, Shuri, Hassan H, Wainford, Richard D, Levy, Philip D, Boggia, José JG, Garré, Laura L, Hernandez-Hernandez, Rafael, Octavio-Seijas, Jose A, Lopez-Rivera, Jesus A, Morr, Igor, Duin, Amanda, Huynh, Minh V, Cao, Sinh T, Nguyen, Viet L, To, Muoi, Phan, Hung N, Cockroft, John, McDonnell, Barry, Goma, Fastone M, Syatalimi, Charity, Chifamba, Jephat, Gwini, Rudo, Tiburcio, Osiris Valdez, Xia, Xin, 20035632 - Kruger, Ruan, 10922180 - Schutte, Aletta Elisabeth, Beaney T., Burrell L.M., Castillo R.R., Charchar F.J., Cro S., Damasceno A., Kruger R., Nilsson P.M., Prabhakaran D., Ramirez A.J., Schlaich M.P., Schutte A.E., Tomaszewski M., Touyz R., Wang J.-G., Weber M.A., Poulter N.R., and Borghi C

Subjects
Male, Cardiac & Cardiovascular Systems, Cross-sectional study, Blood Pressure, 030204 cardiovascular system & hematology, Global Burden of Disease, 0302 clinical medicine, Surveys and Questionnaires, MMM Investigators, Mass Screening, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, Antihypertensive medication, RISK, Global, Awareness, Middle Aged, PREVALENCE, Hypertension, Blood pressure, Screening, Raised blood pressure, Female, Cardiology and Cardiovascular Medicine, BURDEN, Life Sciences & Biomedicine, Control, Adult, medicine.medical_specialty, Fast Track Clinical Research, Opportunistic Sampling, 03 medical and health sciences, Internal medicine, medicine, SYSTEMATIC ANALYSIS, MANAGEMENT, Humans, Mass screening, Disease burden, Antihypertensive Agents, Science & Technology, business.industry, Case-control study, Blood Pressure Determination, Treatment, Editor's Choice, RAMADAN, Cross-Sectional Studies, Cardiovascular System & Hematology, Case-Control Studies, Cardiovascular System & Cardiology, business, Hypertension, Blood pressure, Screening, Global, Treatment, Control
Abstract

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk.

Published
2019

27. Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure

Author

Salazar, Martin R, primary, Espeche, Walter G, additional, Stavile, Rodolfo N, additional, Disalvo, Liliana, additional, Tournier, Andrea, additional, Leiva Sisnieguez, Betty C, additional, Varea, Ana, additional, Leiva Sisnieguez, Carlos E, additional, March, Carlos E, additional, and Carbajal, Horacio A, additional

Published
2017
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28. Consecuencia de los trastornos hipertensivos durante el embarazo (THE) sobre la salud cardiovascular de la mujer

Author

Espeche, Walter G, Ramos, Patricia Carrera, Minetto, Julian, Gomez, Daniela, De Iraola, Ana, Cerri, Gustavo R, and Salazar, Martin R

Abstract

Las pacientes con trastornos hipertensivos del embarazo (THE) tienen mayor riesgo de complicaciones materno-fetales y son la 3er causa de mortalidad materna. Hasta la fecha se conoce que las pacientes que sufren esta condición en el embarazo tienen mayor riesgo a futuro de eventos cardiovasculares (ECV). Nuestro objetivo fue reportar la incidencia de hipertensión nueva en el puerperio. Se realizó un estudio de cohorte en aquellas pacientes embarazadas de alto riesgo que realizaron un monitoreo ambulatorio de la presión arterial (MAPA) entre las semanas 20-30. Se dividieron a las pacientes de acuerdo con los valores de este en aquellas normotensas (NT) e Hipertensas gestacionales (HTG) excluyendo aquellas con hipertensión arterial (HTA) crónica y se siguieron hasta la finalización del embarazo y una evaluación en el puerperio posterior a los 3 meses. Las pacientes con THE (39%) tuvieron mayor incidencia de Preeclampsia y de recién nacidos con bajo peso y pretérmino. Se analizaron 177 embarazadas para el resultado primario. El 33.3% de aquellas con HTG vs 17,2% de las NT (p=0,014) reportaron HTA nueva. El OR de tener nueva HTA fue de 2,3 IC (1,20-4,77) para aquellas con HTG. Como conclusión aquellas pacientes con HTG evaluadas por MAPA entre 20-30 semanas tienen más riesgo de desarrollar HTA nueva en el puerperio, por lo que requieren un seguimiento y control más cercano para evitar complicaciones cardiovasculares a futuro.

Published
2024
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29. Significance of masked and nocturnal hypertension in normotensive women coursing a high-risk pregnancy

Author

Salazar, Martin R., primary, Espeche, Walter G., additional, Leiva Sisnieguez, Betty C., additional, Balbín, Eduardo, additional, Leiva Sisnieguez, Carlos E., additional, Stavile, Rodolfo N., additional, March, Carlos E., additional, Grassi, Florencia, additional, Santillan, Claudia, additional, Cor, Susana, additional, and Carbajal, Horacio A., additional

Published
2016
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32. Comparison of the abilities of the plasma triglyceride/high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance

Author

Salazar, Martin R, primary, Carbajal, Horacio A, additional, Espeche, Walter G, additional, Leiva Sisnieguez, Carlos E, additional, March, Carlos E, additional, Balbín, Eduardo, additional, Dulbecco, Carlos A, additional, Aizpurúa, Marcelo, additional, Marillet, Alberto G, additional, and Reaven, Gerald M, additional

Published
2013
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35. Blood Pressure Response to a Community-Based Program and Long-term Cardiovascular Outcome.

Author

Salazar, Martin R., Espeche, Walter G., Aizpurúa, Marcelo, Leiva Sisnieguez, Betty C., Balbín, Eduardo, Dulbecco, Carlos A., and Carbajal, Horacio A.

Subjects
BLOOD pressure, HEALTH outcome assessment, CARDIOVASCULAR diseases, HYPERTENSION, PREVENTIVE medicine
Abstract

BACKGROUND The significance in terms of the cardiovascular outcome of different patterns of blood pressure (BP) response to community-based activities has not been previously studied. The aim of our study was to evaluate the relationship between changes of BP observed during a community-based program and long-term rate of cardiovascular disease (CVD) events. METHODS A program focused on the prevention of CVDs was implemented in a small city in Argentina over a 6-year period (1997–2003). The program was evaluated using a cohort of 1,526 randomly selected individuals. The population’s mean systolic BP (SBP) decreased approximately 5mm Hg, but BP changes were heterogeneous. Eight years after the intervention had stopped, 1,124 individuals of the cohort were surveyed to evaluate incident CVD events. The sample was divided into 3 SBP change categories during the intervention: decrease (< −5mm Hg), no change (−5 to 5mm Hg) and increase (> 5mm Hg). Cox models were used to estimate the hazard ratio (HR) of CVD events for each category adjusted for age, sex, and baseline BP. RESULTS At the end of the intervention, individuals who had increased their SBP showed an adjusted HR for CVD that was double those whose SBP levels decreased or did not change. An inverse relationship between baseline SBP and ΔSBP was observed: individuals with an increase in BP during the intervention had lower SBP at the beginning of the study. CONCLUSIONS BP increase during the community-based program was an independent predictor of CVD events. [ABSTRACT FROM AUTHOR]

Published
2014
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37. Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort.

Author

Salazar MR, Espeche WG, Aizpurua M, Leiva Sisnieguez BC, Leiva Sisnieguez CD, Dulbecco CA, and Carbajal HA

Subjects
Adolescent, Adult, Aged, Argentina, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Cohort Studies, Female, Humans, Hypertension physiopathology, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Young Adult, Blood Pressure physiology, Cardiovascular Diseases physiopathology
Abstract

Background: Hypertension is a recognized strong risk factor for cardiovascular disease. However, no data was available in our country to quantify the relationship between blood pressure and cardiovascular event., Objective: to quantify the risk of cardiovascular events according to blood pressure categories., Methods: A prospective epidemiological study was conducted in 1526 inhabitants from Rauch City, (Buenos Aires, Argentina) between 1997 and 2012. Subjects were classified into one of these blood-pressure categories: 1-optimal, 2-normal, 3-high-normal, 4-grade 1 hypertension, 5-grade 2 hypertension and 6-grade 3 hypertension. The first CVD event, including unstable angina pectoris, fatal and non-fatal myocardial infarction, myocardial revascularization, and fatal or non-fatal stroke, was defined as the primary endpoint. Multivariable Cox proportional-hazards regression models were used to estimate the relative risk (HR) of CVD according to base-line blood-pressure categories., Results: In 2012, 1124 individuals (73.7% of the baseline sample), 719 women and 405 men (in 1997, aged 45±16 and 46±16 respectively) or their relatives in case of death, could be surveyed again in order to obtain information concerning incident CVD events. Cardiovascular event rates and HR values increased in a stepwise manner across the blood pressure categories (p for trend across categories <0.001 in both sex); however, in subjects aged ≥55 years a j-curve phenomenon was observed, showing the lowest incidence in the high-normal category. In all categories CVD events rates were higher for men., Conclusion: This study quantified relationships between BP and CVD starting from high-normal blood pressure in Argentina.

Published
2016

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