31 results on '"Espadinha, Margarida"'
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2. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors
3. Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders
4. Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin
5. PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors
6. Contributors
7. Novel squaramides with in vitro liver stage antiplasmodial activity
8. Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells.
9. Designing novel spiropyrazoline oxindoles to dual target p53-MDM2/X PPIs
10. Protoflavone – spirooxindole hybrids exhibit promising, increased antitumor activity
11. Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma
12. Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cellsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00251a
13. Chapter 10 - PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors
14. Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma
15. Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders
16. Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line
17. Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity
18. Improving anticancer activity towards colon cancer cells with a new p53‐activating agent
19. Enhancing anticancer activity of spiropyrazoline oxindoles by disrupting p53-MDMs PPIs
20. Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions
21. Enantiopure oxazoloisoindolinones: Promising small molecules for p53-based therapy with potential anticancer properties
22. Bicyclic lactams as potential inhibitors of the NMDA receptor
23. Uncovering the binding of the anticancer small molecule SLMP53-1 to mutant p53R280K
24. Improving anticancer activity towards colon cancer cells with a new p53-activating agent
25. A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide
26. An Update on MDMX and Dual MDM2/X Inhibitors
27. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties
28. Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists
29. Enantiopure bicyclic lactams: synthesis and biological evaluation
30. Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis
31. Tryptophanol-derived oxazoloisoindolinone fluorescent probes for cellular localization studies of p53 activators.
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