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1. Variability in the prescription of biological drugs in rheumatoid arthritis in Spain: a multilevel analysis

Author

López-Longo, Francisco Javier, Seoane-Mato, Daniel, Martín-Martínez, María A., Sánchez-Alonso, Fernando, Escudero, C., Chozas, N., Maries, I., Fernandez, A., Medina, F., Ureña, I., Irigoyen, V., Lopez, M., Espiño, P., Manrique, S., Collantes, E., Font, P., Ruiz, D., Granados, M., Pozuelo, M. J., Moreno, I., Garcia Lopez, A., Pina, J. M., Rosello, R., Vazquez, C., Beltrán, J., Pecondón, A., Giménez, E., Jimenez, F., Marzo, J., Medrano, M., Babio, J., Tinture, T., Gonzalez, S., Ordas, C., Garcia, M. E., Ballina y Alonso S, J., Espadaler, L., Fernandez, J., Fiter, J., Bustabad, S., Rodríguez, C., Naranjo, A., Ojeda, S., Tornero, J., Piqueras, J. A., Judez, E., Sanchez, G., Pantoja, L., Lopez, C., Medina, J., Iglesias, G., Alvarez, M., Alegre, J., Colazo, M. R., Alonso, J. L., Alvarez, B., Perez Sandoval, T., Del Pino, J., Montilla, C., Gomez, S., Lopez, R., Sanchez, M., Arasa, F. X., Castro, S., Ordoñez, S., Boquet, D., Calvet, J., de la Fuente, D., Rios, V., Nolla, M., Martinez, A., Belmonte Serrano, M. A., Negueroles, R., Garcia, J., Gamero y E del Rincon, F., Veroz, R., Perez-Pampin, E., Fernandez, L., Miguelez, R., Godo, J., Ortíz, A. M., Vicente, E., Tomero, E., Casado, A., Aria, M. J, Cuende, E., Bohorquez, C., Rodriguez, J. M., Aragon, A., Garcia, J., Zubieta, J., Martinez, C., Mateo, I., de Juanes y E Enriquez, A, Lopez-Longo, F. J., Maese, J., Pagan, E., Rubira, M. J., Mesa, P., Rivera, N., Rodriguez, C., Gonzalez Alvarez, B., Zea, A., Diaz-Miguel, C., Cifuentes, A., and emAR II Group

Published
2018
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2. Centre-related variability in hospital admissions of patients with spondyloarthritis

Author

Andrés, Mariano, Sivera, Francisca, Pérez-Vicente, Sabina, Carmona, Loreto, Vela, Paloma, Escudero, C., Chozas, N., Maries, I., Fernandez, A., Medina, F., Ureña, I., Irigoyen, V., Lopez, M., Espiño, P., Manrique, S., Collantes, E., Font, P., Ruiz, D., Granados, M., Pozuelo, M. J., Moreno, I., Pina, J. M., Roselló, R., Vázquez, C., Beltrán, J., Manero-Ruiz, F. J., Pecondón, A., Giménez, E., Jimenez, F., Marzo, J., Medrano, M., Babío, J., Tinturé, T., González, S., Ordás, C., García, M. E., Espadaler, L., Fernandez, J., Fiter, J., Naranjo, A., Ojeda, S., Tornero, J., Piqueras, J. A., Júdez, E., López, C., Medina, J., Iglesias, G., Alvarez, M., Alegre, J., Colazo, M. R., Alonso, J. L., Alvárez, B., Montilla, C., Gómez, S., López, R., Sánchez, M., Castro, S., Ordóñez, S., Boquet, D., Calvet, J., de la Fuente, D., Rios, V., Nolla, J. M., Martínez-Cristóbal, A., Negueroles, R., Muñoz, M. L., García, J., Gamero, F., del Rincón, E., Pérez-Pampín, E., Fernandez, L., Miguélez, R., Ortíz, A. M., Vicente, E., Pérez Esteban, S., Tomero, E., Casado, A., Arias, M. J., Cuende, E., Bohorquez, C., Rodríguez, J. M., Aragón, A., García, J., Zubieta, J., Gallego, A., Martínez, C., Mateo, I., de Juanes, A., Enríquez, E., Monteagudo, I., López-Longo, F. J., Pagán, E., Rubira, M. J., Mesa, P., Galvez, J., Saiz, E., Tornero, C., Úcar, E., Rodríguez, C., González Álvarez, B., Rivera, N., Arasa, F. X., Bustabad, S., Delgado, E., Maese, J., Veroz, R., and On behalf of the EMAR II study group

Published
2016
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3. Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

Author

Martin-Martinez M, Castaneda S, Gonzalez-Juanatey C, Sanchez-Alonso F, Garcia-Gomez C, Lopez-Gonzalez R, Babio-Herraiz J, Juan-Mas A, Moreno-Gil M, Sanchez-Gonzalez C, Romera-Baures M, Pinto-Tasende J, Tornero-Molina J, Fabregas-Canales D, Llorca J, Gonzalez-Gay M, de Rabago E, Morales E, Lopez J, Villar N, Sandoval A, Garcia F, De Miquel C, Fernandez M, Codina R, Yoldi B, Ramentol M, Avila G, Barril S, Quesada E, Steiner M, Munoz S, Cobo T, Gamero F, Toron J, Espino P, Ros I, Ibanez M, Murillo C, Sanmarti R, Berman H, Cabrera S, Ruiz V, Paton O, Gutierrez B, Abasolo L, Pina J, Nolla J, Arias M, Vadillo J, de Vicuna R, Nebro A, Arija S, Lopez M, Urena I, Irigoyen M, Cagigal V, Garrido D, Aparicio A, Gomez R, Bautista P, Sanz A, Bachiller J, Manero F, Zorzo F, Ubeda E, Garcia J, Audera C, Medrano M, Pecondon A, Erausquin C, Ojeda S, Quevedo J, Francisco F, Lozano C, Longo F, Gerona D, Fernandez C, Monteagudo I, del Pino J, Gonzalez M, Corrales A, Peiro M, Senabre J, Rosas J, Rotes I, Moreno E, Erra A, Grado D, Calvo J, Rueda A, Moller I, Rodriguez I, Barbadillo C, Raya E, Morales P, Nieto A, Jimenez I, Magro C, Escribano A, Exposito S, Nievas G, Navarro E, Morales M, Bastero I, Consuegra G, Palmou N, Pardo S, Pujol M, Alonso E, Salvador G, Alvarez B, Cantabrana A, Bustabad S, Delgado E, Munoz A, Montero S, Jimenez L, Redondo J, Hernandez T, Polo F, Almagro R, Moreno J, Serret E, Barroso C, Mendez L, Navio M, Carballido C, Pagan E, del Castillo P, Naredo E, Cruz A, Turrion A, Sanchez J, Galindo M, Gonzalez J, Collantes E, Ruiz D, Font P, Bonilla G, Meseguer A, Moreno M, Martinez M, Linares L, Morcillo M, Gomez M, Rivera N, Berrizbeitia O, Vivar M, Riera M, Leon Y, Maymo J, Amirall M, Escolano S, Serrano S, Bona M, Fiter J, Melon J, Espadaler L, Maiz O, Belzunegui J, Banegil I, Diaz C, Valls R, Castellvi I, Bonet M, Ruzafa E, Alen J, Sandoval T, Evrard E, Godo J, Espartero C, Blasco F, Miranda-Filloy J, and CARMA Project Collaborative Grp

Subjects
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, incidence, cohort study, CARMA project, cardiovascular diseases
Abstract

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

Published
2019

4. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C, Martin-Martinez, M, Fernandez C, Castaneda, S, Gonzalez-Juanatey, C, Sanchez-Alonso, F, Gonzalez-Fernandez, M, Sanmarti, R, Garcia-Vadillo, J, Fernandez-Gutierrez, B, Garcia-Arias, M, Manero, F, Senabre, J, Rueda-Cid, A, Ros-Exposito, S, Pina-Salvador, J, Erra-Duran, A, Moller-Parera, I, Llorca, J, Gonzalez-Gay, M, Gonzalez de Rabago, E, Blanco Morales, E, Fernandez Lopez, J, Oreiro Villar, N, Atanes Sandoval, A, Blanco Garcia, F, Alegre De Miquel, C, Gonzalez Fernandez, M, Huguet Codina, R, Yoldi, B, Ramentol, M, Avila, G, Marsal Barril, S, Steiner, M, Munoz, S, Gamero, F, Garcia Toron, J, Moreno Gil, M, Mas, A, Espino, P, Ros, I, Ibanez, M, Murillo, C, Piqueras, J, Berman, H, Cabrera, S, Ruiz, V, Fontsere Paton, O, Fernandez Gutierrez, B, Abasolo, L, Fabregas, M, Romera Baures, M, Nolla, J, Gonzalez-Alvaro, I, Tomero Muriel, E, Garcia de Vicuna, R, Fernandez Nebro, A, Belmonte Lopez, M, Urena, I, Irigoyen, M, Coret Cagigal, V, Lopez Gonzalez, R, Pielfort Garrido, D, Sampedro Alvarez, J, Garcia Aparicio, A, Belmonte Gomez, R, Granados Bautista, P, Hernandez Sanz, A, Sanchez Gonzalez, C, Bachiller, J, Zea, A, Jimenez Zorzo, F, Gimenez Ubeda, E, Marzo Gracia, J, Beltran Audera, C, Medrano, M, Pecondon, A, Erausquin, C, Ojeda, S, Carlos Quevedo, J, Francisco, F, Rodriguez Lozano, C, Babio Herraez, J, Lopez Longo, F, Gerona, D, Gonzalez Fernandez, C, Carreno, L, Monteagudo, I, del Pino, J, Sanchez Gonzalez, M, Corrales, A, Enriqueta Peiro, M, Rosas, J, Rotes, I, Moreno, E, Erra, A, Grado, D, Calvo, J, Rueda, A, Moller, I, Rodriguez, I, Barbadillo, C, Raya, E, Morales, P, Nieto, A, Jimenez, I, Magro, C, Ruibal Escribano, A, Ros Exposito, S, Sanchez Nievas, G, Judez Navarro, E, Sianes Fernandez, M, Garcia Morales, M, Labiano Bastero, I, Consuegra, G, Palmou, N, Martinez Pardo, S, Pujol, M, Riera Alonso, E, Salvador, G, Gonzalez Alvarez, B, Cantabrana, A, Bustabad, S, Delgado, E, Munoz, A, Rodriguez Montero, S, Maria Jimenez, L, Rivera Redondo, J, Gonzalez Hernandez, T, Gonzalez Polo, F, Menor Almagro, R, Moreno, J, Giner Serret, E, Lannuzzelli Barroso, C, Cebrian Mendez, L, Teresa Navio, M, Fernandez Carballido, C, Pagan, E, Mesa del Castillo, P, Naredo, E, Cruz, A, Turrion, A, Mateo, I, Sanchez, J, Galindo, M, Garcia Gonzalez, J, Collantes, E, Ruiz, D, Font, P, Bonilla, G, Lopez Meseguer, A, Moreno, M, Moreno Martinez, M, Beteta Fernandez, M, Linares, L, Morcillo, M, Gonzalez Gomez, M, Aramburu, J, Rivera, N, Fernandez Berrizbeitia, O, Garcia Vivar, M, Riera, M, Maria Leon, Y, Maymo, J, Amirall, M, Iniesta Escolano, S, Sanchez Serrano, S, Lis Bona, M, Fiter, J, Fernandez Melon, J, Espadaler, L, Maiz, O, Belzunegui, J, Banegil, I, Diaz, C, Valls, R, Castellvi, I, Bonet, M, Moreno Ruzafa, E, Calvo Alen, J, Perez Sandoval, T, Revuelta Evrard, E, Godo, J, Fernandez Espartero, C, Navarro Blasco, F, Antonio Gonzalez, J, Miranda-Filloy, J, and CARMA Project Collaborative Grp

Subjects
musculoskeletal diseases, psoriatic arthritis, lipids, stomatognathic diseases, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

Published
2019

5. Orthopedic Surgery in Rheumatoid Arthritis in the Era of Biologic Therapy

Author

Leon, Leticia, Abasolo, Lydia, Carmona, Loreto, Rodriguez-Rodriguez, Luis, Lamas, Jose Ramon, Hernandez-Garcia, Cesar, Jover, Juan Angel, Alegre, J, Alonso, JL, Alvarez, M, Alvárez, B, Aragón, A, Arasa, FX, Arias, MJ, Beltrán, J, Babío, J, Bohorquez, C, Boquet, D, Bustabad, S, Casado, A, Calvet, J, Castro, S, Colazo, MR, Collantes, E, Cuende, E, Chozas, N, Delgado, E, de la Fuente, D, de Juanes, A, del Rincón, E, Enríquez, E, Escudero, C, Espadaler, L, Espino, P, Fernández, A, Fernández, J, Fernández, L, Fiter, J, Font, P, Galvez, J, Gallego, A, García, J, García, J, García, ME, Gamero, F, Giménez, E, Gómez, S, González Álvarez, B, González, S, Granados, M, Iglesias, G, Irigoyen, V, Jimenez, F, Júdez, E, López, C, López, M, López, R, López-Longo, FJ, Maese, J, Manero-Ruiz, FJ, Manrique, S, Maries, I, Martínez, C, Martínez-Cristóbal, A, Mateo, I, Marzo, J, Medina, F, Medina, J, Medrano, M, Mesa, P, Miguélez, R, Monteagudo, I, Montilla, C, Moreno, I, Muñoz, ML, Naranjo, A, Negueroles, R, Nolla, M, Ojeda, S, Ordás, C, Ordóñez, S, Ortíz, AM, Pagán, E, Pecondón, A, Esteban, S, Pérez-Pampín, E, Pina, JM, Piqueras, JA, Pozuelo, MJ, Rios, V, Rivera, N, Rodríguez, C, Rodríguez, JM, Roselló, R, Rubira, MJ, Ruiz, D, Saiz, E, Sánchez, M, Tinturé, T, Tornero, C, Tornero, J, Úcar, E, Ureña, I, Vázquez, C, Veroz, R, Vicente, E, and Zubieta, J

Abstract

Objective.To analyze sociodemographic and clinic-related factors associated with the use of orthopedic surgical procedures in rheumatoid arthritis (RA), focusing on the potential role of new biologic therapies.Methods.A retrospective medical record review was performed in a probability sample of 1272 patients with RA from 47 units distributed in 19 Spanish regions. Sociodemographic and clinical features, use of drugs, and arthritis-related joint surgeries were recorded following a standardized protocol.Results.A total of 94 patients (7.4%) underwent any orthopedic surgery during their disease course, with a total of 114 surgeries; 47 (41.2%) of these surgeries were total joint replacement (TJR). The median time to first orthopedic procedure was 7.9 years from the onset of RA symptoms, and the rate of orthopedic surgery (excluding TJR) was 4.5 procedures per 100 person-years from the beginning of RA, while the rate of TJR was 2.25 interventions per 100 person-years. A higher risk of undergoing an orthopedic surgical procedure was associated with taking nonsteroidal antiinflammatory drugs (NSAID) in the previous 2 years, female sex, longterm disease, and the presence of extraarticular complications. The risk factors for undergoing a TJR were being old, having a longterm disease, and taking biologic therapies.Conclusion.In the era of biologics, our national audit found a low percentage of patients who underwent orthopedic surgery, probably reflecting a thorough management of the RA. Sociodemographic factors, longterm RA, extraarticular complications, and NSAID were associated with orthopedic surgery.

Published
2013
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7. Brucellar Spondylitis: A Detailed Analysis Based on Current Findings

Author

Espadaler L, Valverde J, Pedro Fernández-Viladrich, Roman Pallares, Francisco Gudiol, Fernández-Nogues F, Javier Ariza, and Gabriel Rufi

Subjects
Adult, Male, Microbiology (medical), medicine.medical_specialty, Adolescent, Sulfamethoxazole, Radiography, Brucellosis, Trimethoprim, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, Blood culture, Prospective Studies, Child, Prospective cohort study, Abscess, Spondylitis, Aged, biology, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, biology.organism_classification, Surgery, Drug Combinations, Infectious Diseases, Spain, Bacteremia, Female, business, Brucella melitensis
Abstract

Three hundred thirty-one cases of brucellosis included in a 10-year prospective protocol were reviewed to identify and follow up patients with spondylitis. Of 20 patients (17 male and three female; mean age, 54 years), spondylitis was diagnosed soon after onset of the brucellosis in 15, there were significant systemic symptoms in 17, and blood cultures were positive for Brucella melitensis in 14. The main symptom was vertebral pain. The commonest radiographic changes were narrowing of the disk and epiphysitis. The discrete character of radiographic alterations and negative uptake on bone scanning caused diagnostic delays in three patients. 99mTc bone scans finally became abnormal in all patients, but were not useful for follow-up because low uptake persisted after the clinical status stabilized. Three patients had paravertebral abscesses; in two of them fever and pain persisted despite antibiotic therapy until diagnosis and surgical drainage. Finally, all patients were cured, ten with sequelae. Brucellar spondylitis often had an acute clinical course with bacteremia. Because neither clinical nor radiographic changes one year after onset were significant, long-term follow-up is not considered necessary except when paravertebral abscess is suspected.

Published
1985
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8. Association of apolipoprotein B/apolipoprotein A1 ratio and cardiovascular events in rheumatoid arthritis: Results of the CARMA study

Author

Zegarra-Mondragón, S., López-González, R., Martín-Martínez, M. A., García-Gómez, C., Sánchez-Alonso, F., González-Juanatey, C., Arija, S. M., Hernán, G. B., Pardo, S. M., Escribano, A. R., García, E. P., Frías, E. D., Redondo, J. R., Sánchez, M. D., Cambrón, A. B. R., Ramos, M. J. M., Montero, S. A. R., Marco, M. T. N., Valle, M. M., Gonzalez, J. G., Corral, J. B., Llorca, J., Castañeda, S., González-Gay, M. A., Rabago, E. G., Morales, E. A. B., Carlos Fernández Lopez, J., Villar, N. O., Sandoval, A. A., Blanco García, F. J., Miquel, C. A., González Fernández, M. J., Codina, R. H., Yoldi, B., Ramentol, M., Ávila, G., Barril, S. M., Quesada, E., Steiner, M., Muñoz, S., Cobo, T., Gamero, F., Torón, J. G., Espino, P., Ros, I., Ibáñez, M., Murillo, C., Molina, J. T., Raimon Sanmarti, Berman, H., Cabrera, S., Ruiz, V., Patón, O. F., Gutierrez, B. F., Abasolo, L., Pina, J. M., Canals, D. F., Nolla, J. M., Arias, M. G., Uriarte, M., García Vadillo, J. A., Vicuña, R. G., Nebro, A. F., López, M. A. B., Ureña, I., Irigoyen, M. V., Cagigal, V. C., Garrido, D. P., García Aparicio, A. M., Gómez, R. B., Bautista, P. G., Sanz, A. H., Manero, F. J., Zorzo, F. J., Ubeda, E. G., Gracía, J. M., Audera, C. B., Medrano, M., Pecondón, Á, Erausquin, C., Ojeda, S., Quevedo, J. C., Francisco, F., Lozano, C. R., López Longo, F. J., Gerona, D., Fernández, C. G., Monteagudo, I., Del Pino, J., González, M. D. S., Corrales, A., Peiró, M. E., Senabre, J. M., Rosas, J. C., Rotés, I., Moreno, E., Erra, A., Grado, D., Calvo, J., Rueda, A., Möller, I., Rodríguez, I., Barbadillo, C., Raya, E., Morales, P., Nieto, A., Jiménez, I., Magro, C., Expósito, S. R., Nievas, G. S., Navarro, E. J., Fernández, M. S., García Morales, M. A., Bastero, I. L., Consuegra, G. G., Palmou, N., Pujol, M., Alonso, E. R., Salvador, G., Alvarez, B. G., Cantabrana, A., Bustabad, S., Muñoz, A., Jimenez, L. M., Hernandez, T. G., González Polo, F. J., Almagro, R. M., Moreno, J. M., Serret, E. G., Barroso, C. L., Méndez, L. C., Carballido, C. F., Del Castillo, P. M., Naredo, E., Valenciano, A. C., Villa, C. M., Turrión, A., Sánchez, J., Galindo, M., Collantes, E., Ruiz, D., Font, P., Bonilla, G., Meseguer, A. L., Moreno Martínez, M. J., Beteta Fernández, M. D., Linares, L. F., González Gómez, M. L., Rivera, N. A., Berrizbeitia, O. F., García Vivar, M. L., Riera, M., León, Y. M., Maymó, J., Amirall, M., Escolano, S. I., Serrano, S. S., Lis Bona, M. P., Fiter, J., Melón, J. F., Espadaler, L., Maiz, O., Belzunegui, J., Díaz, C., Valls, R., Castellví, I., Bonet, M., Ruzafa, E. M., Alen, J. C., Sandoval, T. P., Evrard, E. R., Godo, J. R., Espartero, C. F., Navarro Blasco, F. J., Antonio González, J., and Miranda-Filloy, J. A.

10. Assessing treatment tolerability for rheumatoid arthritis. Validation and practical applications of the 'TOL-AR-18 questionnaire'.

Author

Corominas H, Espadaler L, Gómez A, Ros I, Urruticoechea A, Sarmiento M, and Sanmartí R

Subjects
Aged, Cross-Sectional Studies, Female, Health Status, Humans, Male, Middle Aged, Psychometrics, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid drug therapy, Diagnostic Self Evaluation, Self Report
Abstract

Introduction: Given the lack of standardized tools to assess tolerability from patient's perspective, we carried out the validation of a questionnaire to asses treatment tolerability for rheumatoid arthritis (RA): TOL-AR-18., Methods: The TOL-AR-18 was validated in the cross-sectional observational study in adult patients with RA. Socio-demographic and clinical variables were collected. Patients completed the TOL-AR-18 and ARTS questionnaires and a question about their general health status., Results: Data of 66 patients with a mean age (standard deviation; SD) of 56.71 (10.50) years were analyzed; 66.7% were women. Mean (SD) time to disease progression was 10.76 (8.23) years, and time from first treatment initiation was 9.24 (7.70) years. Patients did not report other adverse events rather than those included in the TOL-AR-18. The questionnaire was feasible with high internal consistency (Cronbach's α >0.90). Discriminant validity was moderate, with significant differences between patients in remission and all other, and between patients who did not report adverse events and the rest (P<.05). Convergent validity was moderate-low when correlated with the ARTS questionnaire., Conclusion: The TOL-AR-18 is valid for use in a clinical setting and useful as an additional tool for all professionals to manage and assess tolerability in RA., (Copyright © 2018. Publicado por Elsevier España, S.L.U.)

Published
2020
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