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2. [Celecoxib vs indomethacin and acute gastric lesions in rats].

Author

Laudanno OM, Esnarriaga JM, Cesolari JA, Maglione CB, Aramberry LJ, Sambrano JS, Piombo G, and Rista L

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Celecoxib, Cyclooxygenase Inhibitors administration & dosage, Female, Indomethacin administration & dosage, Male, Necrosis, Pyloric Antrum injuries, Pyrazoles, Rats, Rats, Wistar, Stomach Ulcer pathology, Sulfonamides administration & dosage, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Cyclooxygenase Inhibitors toxicity, Digestive System drug effects, Indomethacin adverse effects, Stomach Ulcer chemically induced, Sulfonamides toxicity
Abstract

In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied. Celecoxib was given each 12 hs orally and subcutaneously during 5 days and gastrointestinal lesions were not found; in contrast, Celecoxib given after indomethacin aggravated antrum gastric ulcers (p < 0.001); intestinal massive necrosis and death were observed in all the rats. We conclude that Celecoxib does not induce gastrointestinal lesions in healthy mucosa; in contrast, Celecoxib amplifies the gastrointestinal lesions induced by indomethacin.

Published
2000

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