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The neutron Time-of-Flight facility (n_TOF) is an innovative facility operative since 2001 at CERN, with three experimental areas. In this paper the n_TOF facility will be described, together with the upgrade of the facility during the Long Shutdown 2 at CERN. The main features of the detectors used for capture fission cross section measurements will be presented with perspectives for the future measurements.

Background and Aim: The cell cycle is an important event in tumor growth and differentiation and several molecules are involved in this process. The aim of this study was to evaluate the expression of cyclin D1 (a cell cycle inducer) and p21 (a cell cycle inhibitor) in ameloblastoma of the jaws. Materials and Methods: In this cross-sectional study, 40 cases of ameloblastoma were selected from the archive of oral pathology department. 3 micron sections were cut from paraffin blocks and immunohistochemically stained with antibody against cyclin D1 and p21waf. Stained cells were counted using an eyepiece graticule and labeling index was calculated. Data were analyzed by SPSS version 11.5 for windows using Mann-Whitney and Wilcoxon signed ranked tests with p0.05). There was no statistically significant difference in expression of cyclin D1 between peripheral and central cells (P>0.05). Expression of p21 protein was detected in nuclei of some tumoral cells. There were no statistically significant differences between p21 expression in unicystic and solid ameloblastoma (P>0.05). P21 expression was statistically different between plexiform and follicular variants of ameloblastoma (P=0.049). The difference between p21 expression in peripheral cells of plexiform and follicular variants was statistically significant (P=0.009). This was not observed in central cells. There was no statistically significant relation between p21 and cyclin D1 expression in ameloblastoma (P>0.05). Conclusion: Based on the results of this study, cyclin D1 expression in ameloblastoma is in high level and it could have an important role in the process of tumorigenesis. P21 expression in ameloblastoma is very faint and its possible effects need further investigation.

Statement of Problem: Root canal cleaning and shaping are important steps in endodontic therapy. In"norder to develop better techniques, new instruments are constantly designed and delivered to the market."nPurpose: The aim of the present study was to compare the effectiveness of one manual with three rotary"nroot canal instrumentations techniques."nMaterials and Methods: In this in-vitro study, 80 mesial roots of freshly extracted human mandibular"nmolars were divided in to four groups equally and prepared by one of the following instrumentation"nmethods profile NiTi rotary system, Protaper NiTi rotary system, Flex Master NiTi rotary system and"nhand NiTi K-file instrumentation. In each root one of the canals was instrumented and the other was used"nas control."nAfter decalcification, cross sections at 3mm and 5mm of apical portion were prepared and examined for"nremaining debris, predentin and smooth walls under light microscope. The data were analyzed by"nKxuskal-Wallis test."nResults: Significantly less debris was found at 3mm cross- section using protaper and Flex Master"ntechniques (P

Statement of Problem: Differentiation of dentigerous cyst from unicystic ameloblastoma, discovering any initial ameloblastic changes in lining epithelium of dentigerous cyst at early stage, and differentiation between hyperplastic odontogenic epithelium in fibrous capsule of dentigerous cyst from ameloblastic proliferation, need to an accurate and reliable technique."nPurpose: The aim of this study was to determine and compare Ki-67 immunoreactivity in various locations of the epithelium of Dentigerous cyst and Unicystic Ameloblastoma."nMaterials and Methods: In this historical Cohort study, 15 cases of dentigerous cyst and 9 cases of unicystic ameloblastoma were selected. Immunohistochemistry staining was performed by M1B-1 (murine monoclonal antibody against Ki-67). The stained nucleous were counted in basal and suprabasal layer of lining epithelium of both lesions in 3000 epithelial cells. Finally, the percentage of positive cells (presented as labeling index) was calculated, t- student test was used to analyze the related data."nResults: Ki-67 (LI) in basal layer of Dentigerous cyst (2.59±1.66) and Unicystic Ameloblastoma (3.76±79) had no significant differences, but Ki-67 (LI) in suprabasal layer of unicystic ameloblastoma (2.15±0.69) was significantly higher than dentigerous cyst (0.77±0.55) P=0.003)."nThe difference between the average numbers of positive cells for Ki-67 (LI) in these two lesions was statistically significant (P

Frequently, diagnosis of lichen planus as a relative common chronic inflammatory mucocutaneous disease, is difficult, therefor, direct Immunofluorescence (DIF) examination is recommended for definite diagnosis. In this study both an statistical analysis of files of oral and maxillofacial pathology department of Dentistry school and direct immunofluorescence examination using paraffin blocks with new method, were performed. According to analysis of 8026 cases, 262 (3.26%) cases were diagnosed as lichen planus; most patients were in fourth decade of their life and most common affected region was buccal mucosa, (69.68%)."nIn direct immunofluorescence study of 14 cases (using firth's method) fibrinogen deposits in 6 cases and immunostaining of colloid bodies with various immunoglobulins (IgA, IgG, IgM), C3 and also fibrinogen (few values) in most of patients, were detected. In spite of the fact that density of staining was lower than routine method (using fresh-frozen tissue), except for fibrinogen immunostaining, these findings are compatible with previous studies. In spile of limitation of samples, this study suggests that using this technique needs more evaluation and this can be used for diagnosis purposes when fresh-frozen tissue is unavailable.

This paper addresses the investigation of axisymmetric thermally induced vibrations in Functionally Graded Material (FGM) cylindrical shells. It considers temperature-dependent (TD) properties and geometric non-linearity (the von Karman effect). The study systematically solves a transient heat conduction equation using finite differences method and the Crank–Nicolson method. During the heating stages, the evaluation of thermal forces and moments takes place. Equations of motion are derived through the application of Hamilton's principle. Spatial dependencies are discretized using the generalized Ritz method, while temporal dependencies are approximated using the β -Newmark method with Newton–Raphson linearization. A comparative analysis validates the procedure's efficiency and precision. Parametric studies explore the influence of parameters, including the temperature-dependency material properties, geometric nonlinearity, and shell's power-law index, providing valuable insights into FGM shell behavior under thermal shock. [ABSTRACT FROM AUTHOR]