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6. Perioperative Bleeding Requiring Blood Transfusions is Associated With Increased Risk of Stroke After Transcatheter and Surgical Aortic Valve Replacement

Author

Tauriainen, Tuomas, Juvonen, Tatu, Anttila, Vesa, Maaranen, Pasi, Niemelä, Matti, Eskola, Markku, Ahvenvaara, Tuomas, Husso, Annastiina, Virtanen, Marko P.O., Kinnunen, Eeva-Maija, Dahlbacka, Sebastian, Jalava, Maina, Laine, Mika, Valtola, Antti, Raivio, Peter, Vento, Antti, Airaksinen, Juhani, Mäkikallio, Timo, and Biancari, Fausto

Published
2022
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7. Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction

Author

Jalava, Maina P., Savontaus, Mikko, Ahvenvaara, Tuomas, Laakso, Teemu, Virtanen, Marko, Niemelä, Matti, Tauriainen, Tuomas, Maaranen, Pasi, Husso, Annastiina, Kinnunen, Eve, Dahlbacka, Sebastian, Jaakkola, Jussi, Rosato, Stefano, D’Errigo, Paola, Laine, Mika, Mäkikallio, Timo, Raivio, Peter, Eskola, Markku, Valtola, Antti, Juvonen, Tatu, Biancari, Fausto, Airaksinen, Juhani, and Anttila, Vesa

Published
2022
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10. Multi-ethnic genome-wide association study for atrial fibrillation

Author

Roselli, Carolina, Chaffin, Mark D, Weng, Lu-Chen, Aeschbacher, Stefanie, Ahlberg, Gustav, Albert, Christine M, Almgren, Peter, Alonso, Alvaro, Anderson, Christopher D, Aragam, Krishna G, Arking, Dan E, Barnard, John, Bartz, Traci M, Benjamin, Emelia J, Bihlmeyer, Nathan A, Bis, Joshua C, Bloom, Heather L, Boerwinkle, Eric, Bottinger, Erwin B, Brody, Jennifer A, Calkins, Hugh, Campbell, Archie, Cappola, Thomas P, Carlquist, John, Chasman, Daniel I, Chen, Lin Y, Chen, Yii-Der Ida, Choi, Eue-Keun, Choi, Seung Hoan, Christophersen, Ingrid E, Chung, Mina K, Cole, John W, Conen, David, Cook, James, Crijns, Harry J, Cutler, Michael J, Damrauer, Scott M, Daniels, Brian R, Darbar, Dawood, Delgado, Graciela, Denny, Joshua C, Dichgans, Martin, Dörr, Marcus, Dudink, Elton A, Dudley, Samuel C, Esa, Nada, Esko, Tonu, Eskola, Markku, Fatkin, Diane, Felix, Stephan B, Ford, Ian, Franco, Oscar H, Geelhoed, Bastiaan, Grewal, Raji P, Gudnason, Vilmundur, Guo, Xiuqing, Gupta, Namrata, Gustafsson, Stefan, Gutmann, Rebecca, Hamsten, Anders, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Hernesniemi, Jussi, Hocking, Lynne J, Hofman, Albert, Horimoto, Andrea RVR, Huang, Jie, Huang, Paul L, Huffman, Jennifer, Ingelsson, Erik, Ipek, Esra Gucuk, Ito, Kaoru, Jimenez-Conde, Jordi, Johnson, Renee, Jukema, J Wouter, Kääb, Stefan, Kähönen, Mika, Kamatani, Yoichiro, Kane, John P, Kastrati, Adnan, Kathiresan, Sekar, Katschnig-Winter, Petra, Kavousi, Maryam, Kessler, Thorsten, Kietselaer, Bas L, Kirchhof, Paulus, Kleber, Marcus E, Knight, Stacey, Krieger, Jose E, Kubo, Michiaki, Launer, Lenore J, Laurikka, Jari, Lehtimäki, Terho, Leineweber, Kirsten, Lemaitre, Rozenn N, Li, Man, Lim, Hong Euy, Lin, Henry J, and Lin, Honghuang

Subjects
Biological Sciences, Genetics, Heart Disease, Cardiovascular, Human Genome, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Atrial Fibrillation, Case-Control Studies, Ethnicity, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Quantitative Trait Loci, Transcriptome, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.

Published
2018

12. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Author

Nolte, Ilja, Munoz, M, Tragante, Vinicius, Amare, Azmeraw, Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy, Bis, Joshua, Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie, Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen, Kluttig, Alexander, Krijthe, Bouwe, Kumar, Jitender, van der Laan, Sander, Lyytikäinen, Leo-Pekka, Maihofer, Adam, Minassian, Arpi, van der Most, Peter, Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James, Thayer, Julian, Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen, de Bakker, Paul, Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob, Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie, Christophersen, Ingrid, Dietrich, Andrea, Ehret, George, Ellinor, Patrick, Eskola, Markku, Felix, Janine, Floras, John, Franco, Oscar, Friberg, Peter, Gademan, Maaike, Geyer, Mark, Giedraitis, Vilmantas, Hartman, Catharina, Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti, Kors, Jan, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy, Lefrandt, Joop, Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian, Lin, Henry, Lindgren, Cecilia, Lubitz, Steven, Mahajan, Anubha, McKnight, Barbara, Zu Schwabedissen, Henriette, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew, Nalls, Mike, Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari, OConnor, Daniel, Ormel, Johan, Perz, Siegfried, Peters, Annette, and Psaty, Bruce

Abstract

This corrects the article DOI: 10.1038/ncomms15805.

Published
2017

13. Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Author

Nolte, Ilja M, Munoz, M Loretto, Tragante, Vinicius, Amare, Azmeraw T, Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L, Bis, Joshua C, Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M, Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P, Kumar, Jitender, van der Laan, Sander W, Lyytikäinen, Leo-Pekka, Maihofer, Adam X, Minassian, Arpi, van der Most, Peter J, Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D, Thayer, Julian F, Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G, de Bakker, Paul IW, Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J, Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R, Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F, Floras, John S, Franco, Oscar H, Friberg, Peter, Gademan, Maaike GJ, Geyer, Mark A, Giedraitis, Vilmantas, Hartman, Catharina A, Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M, Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C, Lefrandt, Joop D, Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C, Lin, Henry J, Lindgren, Cecilia M, Lubitz, Steven A, Mahajan, Anubha, McKnight, Barbara, Zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P, Nalls, Mike A, Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E, O'Connor, Daniel T, Ormel, Johan, Perz, Siegfried, Peters, Annette, and Psaty, Bruce M

Subjects
Humans, Heart Diseases, Genetic Predisposition to Disease, RGS Proteins, Potassium Channels, Muscle Proteins, Risk Factors, Cohort Studies, Blood Pressure, Heart Rate, Polymorphism, Single Nucleotide, Quantitative Trait Loci, European Continental Ancestry Group, Genome-Wide Association Study, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Cardiovascular, Genetics, Heart Disease
Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74g

Published
2017

15. Acute Kidney Injury Following Aortic Valve Replacement in Patients Without Chronic Kidney Disease

Author

Moriyama, Noriaki, Laakso, Teemu, Raivio, Peter, Dahlbacka, Sebastian, Kinnunen, Eeva-Maija, Juvonen, Tatu, Valtola, Antti, Husso, Annastiina, Jalava, Maina P., Ahvenvaara, Tuomas, Tauriainen, Tuomas, Piuhola, Jarkko, Lahtinen, Asta, Niemelä, Matti, Mäkikallio, Timo, Virtanen, Marko, Maaranen, Pasi, Eskola, Markku, Savontaus, Mikko, Airaksinen, Juhani, Biancari, Fausto, and Laine, Mika

Published
2021
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18. Comparison of Survival of Transfemoral Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Risk Patients Without Coronary Artery Disease

Author

Virtanen, Marko P.O., Airaksinen, Juhani, Niemelä, Matti, Laakso, Teemu, Husso, Annastiina, Jalava, Maina P., Tauriainen, Tuomas, Maaranen, Pasi, Kinnunen, Eeva-Maija, Dahlbacka, Sebastian, Rosato, Stefano, Savontaus, Mikko, Juvonen, Tatu, Laine, Mika, Mäkikallio, Timo, Valtola, Antti, Raivio, Peter, Eskola, Markku, and Biancari, Fausto

Published
2020
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20. Cohort Description for MADDEC – Mass Data in Detection and Prevention of Serious Adverse Events in Cardiovascular Disease

Author

Hernesniemi, Jussi A., Mahdiani, Shadi, Lyytikäinen, Leo-Pekka, Lehtimäki, Terho, Eskola, Markku, Nikus, Kjell, Antila, Kari, Oksala, Niku, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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21. Blood Transfusion and Outcome After Transfemoral Transcatheter Aortic Valve Replacement

Author

Maaranen, Pasi, Husso, Annastiina, Tauriainen, Tuomas, Lahtinen, Asta, Valtola, Antti, Ahvenvaara, Tuomas, Virtanen, Marko, Laakso, Teemu, Kinnunen, Eeva-Maija, Dahlbacka, Sebastian, Juvonen, Tatu, Mäkikallio, Timo, Jalava, Maina P., Jaakkola, Jussi, Airaksinen, Juhani, Vasankari, Tuija, Rosato, Stefano, Savontaus, Mikko, Laine, Mika, Raivio, Peter, Niemelä, Matti, Mennander, Ari, Eskola, Markku, and Biancari, Fausto

Published
2019
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23. Mid-term outcomes of Sapien 3 versus Perimount Magna Ease for treatment of severe aortic stenosis

Author

Virtanen, Marko P. O., Eskola, Markku, Savontaus, Mikko, Juvonen, Tatu, Niemelä, Matti, Laakso, Teemu, Husso, Annastiina, Jalava, Maina P., Tauriainen, Tuomas, Ahvenvaara, Tuomas, Maaranen, Pasi, Kinnunen, Eeva-Maija, Dahlbacka, Sebastian, Laine, Mika, Mäkikallio, Timo, Valtola, Antti, Raivio, Peter, Rosato, Stefano, D’Errigo, Paola, Vento, Antti, Airaksinen, Juhani, and Biancari, Fausto

Published
2020
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24. Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study

Author

Laukkanen, Jari A., Kunutsor, Setor K., Hernesniemi, Jussi, Immonen, Jaakko, Eskola, Markku, Zaccardi, Francesco, Niemelä, Matti, Mäkikallio, Timo, Hagnäs, Magnus, Piuhola, Jarkko, Juvonen, Jukka, Rummukainen, Juha, Sia, Jussi, Kervinen, Kari, Karvanen, Juha, Nikus, Kjell, KARDIO Study Group, Tampere University, Clinical Medicine, and TAYS Heart Centre

Subjects
kuolleisuus, väestötutkimus, alipainoisuus, Cardiology, body mass index, Coronary Angiography, 3121 Internal medicine, Body Mass Index, Thinness, varjoainetutkimus, Risk Factors, Humans, angiography, Radiology, Nuclear Medicine and imaging, Obesity, painoindeksi, ylipaino, General Medicine, mortality, Treatment Outcome, hospital register, Cardiovascular Diseases, sepelvaltimotauti, sydän- ja verisuonitaudit, lihavuus, seurantatutkimus, Cardiology and Cardiovascular Medicine, coronary artery disease
Abstract

Background: In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography. Methods: We utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut-offs or transformed using P-splines. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for all-cause mortality. Results: During a median follow-up of 4.9 years, 4688 all-cause deaths occurred. BMI was nonlinearly associated with mortality risk: compared to normal weight category (18.5–25 kg/m2), the age-adjusted HRs (95% CIs) for all-cause mortality were 1.90 (1.49, 2.43), 0.96 (0.92, 1.01), 1.04 (0.99, 1.09), 1.08 (0.96, 1.20), and 1.45 (1.22, 1.72) for underweight (40 kg/m2), respectively. The corresponding multivariable adjusted HRs (95% CIs) were 2.00 (1.55, 2.58), 0.92 (0.88, 0.97) 1.01 (0.95, 1.06), 1.10 (0.98, 1.23), and 1.49 (1.26, 1,78), respectively. Conclusions: In patients undergoing coronary angiography, underweight and obesity class III are associated with increased mortality risk, and the lowest mortality was observed in the preobesity class. It appears the obesity paradox may be present in patients who undergo invasive coronary procedures. publishedVersion

Published
2022

25. Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial

Author

Mäkikallio, Timo, Holm, Niels R, Lindsay, Mitchell, Spence, Mark S, Erglis, Andrejs, Menown, Ian B A, Trovik, Thor, Eskola, Markku, Romppanen, Hannu, Kellerth, Thomas, Ravkilde, Jan, Jensen, Lisette O, Kalinauskas, Gintaras, Linder, Rikard B A, Pentikainen, Markku, Hervold, Anders, Banning, Adrian, Zaman, Azfar, Cotton, Jamen, Eriksen, Erlend, Margus, Sulev, Sørensen, Henrik T, Nielsen, Per H, Niemelä, Matti, Kervinen, Kari, Lassen, Jens F, Maeng, Michael, Oldroyd, Keith, Berg, Geoff, Walsh, Simon J, Hanratty, Colm G, Kumsars, Indulis, Stradins, Peteris, Steigen, Terje K, Fröbert, Ole, Graham, Alastair N J, Endresen, Petter C, Corbascio, Matthias, Kajander, Olli, Trivedi, Uday, Hartikainen, Juha, Anttila, Vesa, Hildick-Smith, David, Thuesen, Leif, and Christiansen, Evald H

Published
2016
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29. Comparison of 30-Day and 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients Aged ≤50 Years (the Coronary aRtery diseAse in younG adultS Study)

Author

Biancari, Fausto, Gudbjartsson, Tomas, Heikkinen, Jouni, Anttila, Vesa, Mäkikallio, Timo, Jeppsson, Anders, Thimour-Bergström, Linda, Mignosa, Carmelo, Rubino, Antonino S., Kuttila, Kari, Gunn, Jarmo, Wistbacka, Jan-Ola, Teittinen, Kari, Korpilahti, Kari, Onorati, Francesco, Faggian, Giuseppe, Vinco, Giulia, Vassanelli, Corrado, Ribichini, Flavio, Juvonen, Tatu, Axelsson, Tomas A., Sigurdsson, Axel F., Karjalainen, Pasi P., Mennander, Ari, Kajander, Olli, Eskola, Markku, Ilveskoski, Erkki, D'Oria, Veronica, De Feo, Marisa, Kiviniemi, Tuomas, and Airaksinen, K.E. Juhani

Published
2014
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31. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B, Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriëtte, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J.M, Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Published
2017
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33. The S1S2S3 electrocardiographic pattern — Prevalence and relation to cardiovascular and pulmonary diseases in the general population

Author

Nurminen, Joonas, primary, Pérez-Riera, Andrés Ricardo, additional, de Luna, Antonio Bayés, additional, Nikus, Kjell, additional, Lyytikäinen, Leo-Pekka, additional, Huhtala, Heini, additional, Eskola, Markku, additional, Kähönen, Mika, additional, Jula, Antti, additional, Lehtimäki, Terho, additional, and Hernesniemi, Jussi, additional

Published
2022
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34. The prognostic significance of the electrical QRS axis on long-term mortality in acute coronary syndrome patients - The TACOS study

Author

Punkka, Olli, primary, Kurvinen, Henri-Jussi, additional, Koivula, Kimmo, additional, Eskola, Markku J., additional, Martiskainen, Mika, additional, Huhtala, Heini, additional, Virtanen, Vesa K., additional, Mikkelsson, Jussi, additional, Järvelä, Kati, additional, Laurikka, Jari, additional, Niemelä, Kari O., additional, Karhunen, Pekka J., additional, Pérez-Riera, Andrés Ricardo, additional, and Nikus, Kjell C., additional

Published
2022
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35. Interatrial block and P terminal force in the general population – Longitudinal changes, risk factors and prognosis

Author

Istolahti, Tiia, primary, Eranti, Antti, additional, Huhtala, Heini, additional, Tynkkynen, Juho, additional, Lyytikäinen, Leo-Pekka, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Eskola, Markku, additional, Anttila, Ismo, additional, Jula, Antti, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2022
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38. Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study

Author

Rankinen, Jani, primary, Haataja, Petri, additional, Lyytikäinen, Leo-Pekka, additional, Huhtala, Heini, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Eskola, Markku, additional, Tuohinen, Suvi, additional, Pérez-Riera, Andrés Ricardo, additional, Jula, Antti, additional, Rissanen, Harri, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2022
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39. The Association of Atrial Fibrillation Before Percutaneous Coronary Intervention With 1-Year Outcome in ST-Elevation Myocardial Infarction Patients

Author

Anttonen, Eero, primary, Punkka, Olli, additional, Leivo, Joonas, additional, Jolly, Sanjit S., additional, Džavík, Vladimír, additional, Koivumäki, Jyri, additional, Tahvanainen, Minna, additional, Koivula, Kimmo, additional, Nikus, Kjell, additional, Wang, Jia, additional, Cairns, John A., additional, Niemelä, Kari, additional, and Eskola, Markku, additional

Published
2021
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41. The prognostic significance of grade of ischemia in the ECG in patients with ST-elevation myocardial infarction: A substudy of the randomized trial of primary PCI with or without routine manual thrombectomy (TOTAL trial)

Author

Leivo, Joonas, primary, Anttonen, Eero, additional, Jolly, Sanjit S., additional, Dzavik, Vladimir, additional, Koivumäki, Jyri, additional, Tahvanainen, Minna, additional, Koivula, Kimmo, additional, Nikus, Kjell, additional, Wang, Jia, additional, Cairns, John A., additional, Niemelä, Kari, additional, and Eskola, Markku, additional

Published
2021
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42. Feasibility and repeatability of optical coherence tomography measurements of pre-stent thrombus burden in patients with STEMI treated with primary PCI

Author

Kajander, Olli A., Koistinen, Laura S., Eskola, Markku, Huhtala, Heini, Bhindi, Ravinay, Niemelä, Kari, Jolly, Sanjit S., Sheth, Tej, Sheth, T., Jolly, S., Kassam, S., Vijayraghavan, R., Lavi, S., Bhindi, R., Niemela, K., Kajander, O., Fung, A., Cheema, A., Alexopoulos, D., Kocka, V., Cantor, W., Stankovic, G., Dzavik, V., and Della Siega, A.

Published
2015
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44. High-risk ECG patterns in ST elevation myocardial infarction for mortality prediction.

Author

Lahti, Roope, Rankinen, Jani, Lyytikäinen, Leo-Pekka, Eskola, Markku, Nikus, Kjell, and Hernesniemi, Jussi

Abstract

We explored the pre-intervention (first medical contact) electrocardiographic (ECG) patterns and their relation to survival among patients with acute myocardial infarction, who presented either with ST elevation (ST elevation myocardial infarction, STEMI) or LBBB, and who underwent emergent coronary angiography in a region with a 24/7/365 STEMI network. This is a retrospective analysis of 1363 consecutive patients hospitalized for first STEMI between the years 2014 and 2018. We assessed the prognostic significance of a variety of ECG categories, including location of ST elevation, severity of ischemia, intraventricular and atrioventricular conduction disorders, atrial fibrillation or flutter, junctional rhythms, heart rate, left ventricular hypertrophy and Q waves. The primary outcome was all-cause mortality between January 2014 and the end of 2020. The mean age of the patients was 67.9 (SD 12.8) years. The majority were treated by percutaneous coronary intervention (93.8%, n = 1278). Median follow-up time was 3.7 years (IQR 2.5–5.1 years) during which 22.5% (n = 307) of the patients died. According to Cox regression analysis, adjusted for pre-existing conditions and age, the ECG variables with statistically significant association with survival were elevated heart rate (>100 bpm) (HR 2.34, 95% CI 1.75–3.12), atrial fibrillation or flutter (HR 1.94, 95% CI 1.41–2.67), left bundle branch block (LBBB) (HR 2.62, 95% CI 1.49–4.63) and non-specific intraventricular conduction delay (NIVCD) (HR 1.85, 95% CI 1.22–2.89). Higher heart rate, atrial fibrillation or flutter, LBBB and NIVCD are associated with worse outcome in all-comers with STEMI. Ischemia severity was not associated with impaired prognosis. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Sex based analysis of the impact of red blood cell transfusion and vascular or bleeding complications related to TAVI – The TRITAVI-Women Study

Author

Rodriguez-Gabella, Tania, primary, Zimarino, Marco, additional, Barbanti, Marco, additional, Testa, Luca, additional, Capodanno, Davide, additional, Stefanini, Giulio G., additional, Radico, Francesco, additional, Fabbiocchi, Franco, additional, Piva, Tommaso, additional, Saia, Francesco, additional, Biancari, Fausto, additional, Eskola, Markku, additional, Niemelä, Matti, additional, Airaksinen, Juhani, additional, Valtola, Antti, additional, Raivio, Peter, additional, Reimers, Bernhard, additional, Picci, Andrea, additional, Nicolini, Elisa, additional, Olivares, Paolo, additional, Moretti, Carolina, additional, Maddestra, Nicola, additional, Bedogni, Francesco, additional, Gallina, Sabina, additional, Tamburino, Corrado, additional, and Amat-Santos, Ignacio J., additional

Published
2021
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46. The Association of Atrial Fibrillation Before Percutaneous Coronary Intervention With 1-Year Outcome in ST-Elevation Myocardial Infarction Patients

Author

Anttonen, Eero, Punkka, Olli, Leivo, Joonas, Jolly, Sanjit S., Džavík, Vladimír, Koivumäki, Jyri, Tahvanainen, Minna, Koivula, Kimmo, Nikus, Kjell, Wang, Jia, Cairns, John A., Niemelä, Kari, Eskola, Markku, Faculty of Medicine, Department of Medicine, and HUS Helsinki and Uusimaa Hospital District

Subjects
3121 General medicine, internal medicine and other clinical medicine
Abstract

Cited by: 1; All Open Access, Gold Open Access, Green Open Access

Published
2021

47. sj-docx-1-sjp-10.1177_14034948211038422 – Supplemental material for Emergency department visits due to coronary artery disease during COVID-19 in Finland: A register-based study

Author

Uimonen, Mikko, Ponkilainen, Ville, Kuitunen, Ilari, Eskola, Markku, and Mattila, Ville M.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-sjp-10.1177_14034948211038422 for Emergency department visits due to coronary artery disease during COVID-19 in Finland: A register-based study by Mikko Uimonen, Ville Ponkilainen, Ilari Kuitunen, Markku Eskola and Ville M. Mattila in Scandinavian Journal of Public Health

Published
2021
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48. The Association of Atrial Fibrillation before Percutaneous Coronary Intervention with 1-Year Outcome in ST-elevation Myocardial Infarction patients : The Outcome of STEMI patients with Pre-PCI AF

Author

Anttonen, Eero, Punkka, Olli, Leivo, Joonas, Jolly, Sanjit S., Džavík, Vladimír, Koivumäki, Jyri, Tahvanainen, Minna, Koivula, Kimmo, Nikus, Kjell, Wang, Jia, Cairns, John A., Niemelä, Kari, Eskola, Markku, Tampere University, TAYS Heart Centre, and Clinical Medicine

Subjects
cardiovascular diseases, 3121 Internal medicine
Abstract

Background: We aimed to determine the association of atrial fibrillation (AF) with 1-year outcome in STEMI patients undergoing primary PCI. Methods: Patients (n=8,830) enrolled in the Trial of Routine Aspiration Thrombectomy with PCI versus PCI Alone in Patients with STEMI (TOTAL) were followed for one year. The primary outcome was a composite of cardiovascular death, recurrent MI, cardiogenic shock or new or worsening class IV heart failure. The presence or absence of AF was determined from a single pre-PCI ECG. Results: Patients with AF (n=437, 4.9%) were older, and more often had a history of stroke, hypertension or MI. The rate of the primary outcome was higher in the AF group than in the sinus rhythm (SR) group (17.4% vs. 7.4%, p

Published
2021

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