Background and study aims Despite the common occurrence of non-neoplastic findings (NNFs) in individuals with a positive fecal immunochemical test (FIT), few studies have reported on these findings. The aim of this cross-sectional study was to determine the prevalence of colonic NNFs in three cohorts of Danish clinical trial participants who underwent colon capsule endoscopy (CCE). Patients and methods Retrospectively collecting NNFs from CCE reports of three Danish trials, we classified them into five categories: diverticula, vascular abnormalities, inflammation, erosions/ulcerations, and others. The statistical analysis included 516 participants from three trials, with a mean age ranging from 59.2 to 63.9 years. The participants in the three trials were FIT-positive screening or symptomatic individuals. Results NNFs were reported in more than half of the CCE procedures (50.6% to 77.9%), with colonic diverticula being the most common NNF appearing in 40.9% to 66.9% of the CCE reports. Vascular abnormalities and erosions/ulcerations were also common depending on the specific trial. Conclusions NNFs are common and may be an indicator of more widespread disease. Furthermore, NNFs may develop into clinically significant conditions despite their benign appearance. This paper expands on the limited literature about prevalence of NNFs and underscores the additional value of CCE video recordings beyond detecting polyps., Competing Interests: Conflict of Interest Sebastian Radic Eskemose, Lasse Kaalby Møller, and Ulrik Deding have no conflicts of interest or financial ties to disclose. Anastasios Koulaouzidis has received consultancy fees from Jinshan Science and Technology (Group) Co. Ltd. (Jinshan Group) and Corporate Health International, received honoraria from Jinshan Group and Medtronic, received travel support by Jinshan Group, has issued a patent with AJM Med-i-Caps Ltd., and has equity interest in iCERV Ltd. and AJM Med-i-Caps Ltd. Thomas Bjørsum-Meyer has received consulting fees from Medtronic. The funders had no role in the design of the paper; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)