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1. On Equivalence of Likelihood-Based Confidence Bands for Fatigue-Life and Fatigue-Strength Distributions

Author

Liu, Peng, Hong, Yili, Escobar, Luis A., and Meeker, William Q.

Subjects
Statistics - Methodology, Mathematics - Statistics Theory
Abstract

Fatigue data arise in many research and applied areas and there have been statistical methods developed to model and analyze such data. The distributions of fatigue life and fatigue strength are often of interest to engineers designing products that might fail due to fatigue from cyclic-stress loading. Based on a specified statistical model and the maximum likelihood method, the cumulative distribution function (cdf) and quantile function (qf) can be estimated for the fatigue-life and fatigue-strength distributions. Likelihood-based confidence bands then can be obtained for the cdf and qf. This paper provides equivalence results for confidence bands for fatigue-life and fatigue-strength models. These results are useful for data analysis and computing implementation. We show (a) the equivalence of the confidence bands for the fatigue-life cdf and the fatigue-life qf, (b) the equivalence of confidence bands for the fatigue-strength cdf and the fatigue-strength qf, and (c) the equivalence of confidence bands for the fatigue-life qf and the fatigue-strength qf. Then we illustrate the usefulness of those equivalence results with two examples using experimental fatigue data.

Published
2024

6. Modern Statistical Models and Methods for Estimating Fatigue-Life and Fatigue-Strength Distributions from Experimental Data

Author

Meeker, William Q., Escobar, Luis A., Pascual, Francis G., Hong, Yili, Liu, Peng, Falk, Wayne M., and Ananthasayanam, Balajee

Subjects
Statistics - Methodology
Abstract

Engineers and scientists have been collecting and analyzing fatigue data since the 1800s to ensure the reliability of life-critical structures. Applications include (but are not limited to) bridges, building structures, aircraft and spacecraft components, ships, ground-based vehicles, and medical devices. Engineers need to estimate S-N relationships (Stress or Strain versus Number of cycles to failure), typically with a focus on estimating small quantiles of the fatigue-life distribution. Estimates from this kind of model are used as input to models (e.g., cumulative damage models) that predict failure-time distributions under varying stress patterns. Also, design engineers need to estimate lower-tail quantiles of the closely related fatigue-strength distribution. The history of applying incorrect statistical methods is nearly as long and such practices continue to the present. Examples include treating the applied stress (or strain) as the response and the number of cycles to failure as the explanatory variable in regression analyses (because of the need to estimate strength distributions) and ignoring or otherwise mishandling censored observations (known as runouts in the fatigue literature). The first part of the paper reviews the traditional modeling approach where a fatigue-life model is specified. We then show how this specification induces a corresponding fatigue-strength model. The second part of the paper presents a novel alternative modeling approach where a fatigue-strength model is specified and a corresponding fatigue-life model is induced. We explain and illustrate the important advantages of this new modeling approach., Comment: 82 pages, 30 figures. Made some minor revision and reduced the appendix

Published
2022

7. Oropouche Fever: A Growing Threat in Latin America

Author

Navarro, Juan-Carlos, Romero-Alvarez, Daniel, Escobar, Luis, Aguilar, Patricia V., Correia Dantas, Eustógio W., Series Editor, Rabassa, Jorge, Series Editor, Gasparini, Germán Mariano, Series Editor, Pujol, Flor H., editor, and Paniz-Mondolfi, Alberto E., editor

Published
2024
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14. The 2023 Latin America report of the Lancet Countdown on health and climate change: the imperative for health-centred climate-resilient development

Author

Hartinger, Stella M., Palmeiro-Silva, Yasna K., Llerena-Cayo, Camila, Blanco-Villafuerte, Luciana, Escobar, Luis E., Diaz, Avriel, Sarmiento, Juliana Helo, Lescano, Andres G., Melo, Oscar, Rojas-Rueda, David, Takahashi, Bruno, Callaghan, Max, Chesini, Francisco, Dasgupta, Shouro, Posse, Carolina Gil, Gouveia, Nelson, Martins de Carvalho, Aline, Miranda-Chacón, Zaray, Mohajeri, Nahid, Pantoja, Chrissie, Robinson, Elizabeth J.Z., Salas, Maria Fernanda, Santiago, Raquel, Sauma, Enzo, Santos-Vega, Mauricio, Scamman, Daniel, Sergeeva, Milena, Souza de Camargo, Tatiana, Sorensen, Cecilia, Umaña, Juan D., Yglesias-González, Marisol, Walawender, Maria, Buss, Daniel, and Romanello, Marina

Published
2024
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15. ENM2020: A Free Online Course and Set of Resources on Modeling Species' Niches and Distributions

Author

Peterson, A Townsend, Aiello-Lammens, Matthew, Amatulli, Giuseppe, Anderson, Robert, Cobos, Marlon, Diniz-Filho, José Alexandre, Escobar, Luis, Feng, Xiao, Franklin, Janet, Gadelha, Luiz, Georges, Damien, Guéguen, M, Gueta, Tomer, Ingenloff, Kate, Jarvie, Scott, Jiménez, Laura, Karger, Dirk, Kass, Jamie, Kearney, Michael, Loyola, Rafael, Machado-Stredel, Fernando, Martínez-Meyer, Enrique, Merow, Cory, Mondelli, Maria Luiza, Mortara, Sara, Muscarella, Robert, Myers, Corinne, Naimi, Babak, Noesgaard, Daniel, Ondo, Ian, Osorio-Olvera, Luis, Owens, Hannah, Pearson, Richard, Pinilla-Buitrago, Gonzalo, Sánchez-Tapia, Andrea, Saupe, Erin, Thuiller, Wilfried, Varela, Sara, Warren, Dan, Wieczorek, John, Yates, Katherine, Zhu, Gengping, Zuquim, Gabriela, and Zurell, Damaris

Subjects
Ecological niche model, Species distribution model, Course, Open access, Methods
Abstract

The field of distributional ecology has seen considerable recent attention, particularly surrounding the theory, protocols, and tools for Ecological Niche Modeling (ENM) or Species Distribution Modeling (SDM). Such analyses have grown steadily over the past two decades—including a maturation of relevant theory and key concepts—but methodological consensus has yet to be reached. In response, and following an online course taught in Spanish in 2018, we designed a comprehensive English-language course covering much of the underlying theory and methods currently applied in this broad field. Here, we summarize that course, ENM2020, and provide links by which resources produced for it can be accessed into the future. ENM2020 lasted 43 weeks, with presentations from 52 instructors, who engaged with >2500 participants globally through >14,000 hours of viewing and >90,000 views of instructional video and question-and-answer sessions. Each major topic was introduced by an “Overview” talk, followed by more detailed lectures on subtopics. The hierarchical and modular format of the course permits updates, corrections, or alternative viewpoints, and generally facilitates revision and reuse, including the use of only the Overview lectures for introductory courses. All course materials are free and openly accessible (CC-BY license) to ensure these resources remain available to all interested in distributional ecology.

Published
2022

16. Genotype–phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders

Author

Mannucci, Ilaria, Dang, Nghi DP, Huber, Hannes, Murry, Jaclyn B, Abramson, Jeff, Althoff, Thorsten, Banka, Siddharth, Baynam, Gareth, Bearden, David, Beleza-Meireles, Ana, Benke, Paul J, Berland, Siren, Bierhals, Tatjana, Bilan, Frederic, Bindoff, Laurence A, Braathen, Geir Julius, Busk, Øyvind L, Chenbhanich, Jirat, Denecke, Jonas, Escobar, Luis F, Estes, Caroline, Fleischer, Julie, Groepper, Daniel, Haaxma, Charlotte A, Hempel, Maja, Holler-Managan, Yolanda, Houge, Gunnar, Jackson, Adam, Kellogg, Laura, Keren, Boris, Kiraly-Borri, Catherine, Kraus, Cornelia, Kubisch, Christian, Le Guyader, Gwenael, Ljungblad, Ulf W, Brenman, Leslie Manace, Martinez-Agosto, Julian A, Might, Matthew, Miller, David T, Minks, Kelly Q, Moghaddam, Billur, Nava, Caroline, Nelson, Stanley F, Parant, John M, Prescott, Trine, Rajabi, Farrah, Randrianaivo, Hanitra, Reiter, Simone F, Schuurs-Hoeijmakers, Janneke, Shieh, Perry B, Slavotinek, Anne, Smithson, Sarah, Stegmann, Alexander PA, Tomczak, Kinga, Tveten, Kristian, Wang, Jun, Whitlock, Jordan H, Zweier, Christiane, McWalter, Kirsty, Juusola, Jane, Quintero-Rivera, Fabiola, Fischer, Utz, Yeo, Nan Cher, Kreienkamp, Hans-Jürgen, and Lessel, Davor

Subjects
Biological Sciences, Genetics, Pediatric, Clinical Research, Mental Health, Prevention, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Animals, Biomarkers, Gene Expression, Gene Knockdown Techniques, Genetic Association Studies, Genetic Predisposition to Disease, Germ-Line Mutation, HEK293 Cells, Humans, Immunohistochemistry, Mutation, Neurodevelopmental Disorders, Phenotype, RNA Helicases, Zebrafish, Clinical Sciences
Abstract

BackgroundWe aimed to define the clinical and variant spectrum and to provide novel molecular insights into the DHX30-associated neurodevelopmental disorder.MethodsClinical and genetic data from affected individuals were collected through Facebook-based family support group, GeneMatcher, and our network of collaborators. We investigated the impact of novel missense variants with respect to ATPase and helicase activity, stress granule (SG) formation, global translation, and their effect on embryonic development in zebrafish. SG formation was additionally analyzed in CRISPR/Cas9-mediated DHX30-deficient HEK293T and zebrafish models, along with in vivo behavioral assays.ResultsWe identified 25 previously unreported individuals, ten of whom carry novel variants, two of which are recurrent, and provide evidence of gonadal mosaicism in one family. All 19 individuals harboring heterozygous missense variants within helicase core motifs (HCMs) have global developmental delay, intellectual disability, severe speech impairment, and gait abnormalities. These variants impair the ATPase and helicase activity of DHX30, trigger SG formation, interfere with global translation, and cause developmental defects in a zebrafish model. Notably, 4 individuals harboring heterozygous variants resulting either in haploinsufficiency or truncated proteins presented with a milder clinical course, similar to an individual harboring a de novo mosaic HCM missense variant. Functionally, we established DHX30 as an ATP-dependent RNA helicase and as an evolutionary conserved factor in SG assembly. Based on the clinical course, the variant location, and type we establish two distinct clinical subtypes. DHX30 loss-of-function variants cause a milder phenotype whereas a severe phenotype is caused by HCM missense variants that, in addition to the loss of ATPase and helicase activity, lead to a detrimental gain-of-function with respect to SG formation. Behavioral characterization of dhx30-deficient zebrafish revealed altered sleep-wake activity and social interaction, partially resembling the human phenotype.ConclusionsOur study highlights the usefulness of social media to define novel Mendelian disorders and exemplifies how functional analyses accompanied by clinical and genetic findings can define clinically distinct subtypes for ultra-rare disorders. Such approaches require close interdisciplinary collaboration between families/legal representatives of the affected individuals, clinicians, molecular genetics diagnostic laboratories, and research laboratories.

Published
2021

17. The Implosion of Memory. City and Drug Trafficking in Medellín and the Aburrá Valley

Author

González Escobar, Luis Fernando, Angelidou, Margarita, Editorial Board Member, Farnaz Arefian, Fatemeh, Editorial Board Member, Batty, Michael, Editorial Board Member, Davoudi, Simin, Editorial Board Member, DeVerteuil, Geoffrey, Editorial Board Member, González Pérez, Jesús M., Editorial Board Member, Hess, Daniel B., Editorial Board Member, Jones, Paul, Editorial Board Member, Karvonen, Andrew, Editorial Board Member, Kirby, Andrew, Editorial Board Member, Kropf, Karl, Editorial Board Member, Lucas, Karen, Editorial Board Member, Maretto, Marco, Editorial Board Member, Modarres, Ali, Editorial Board Member, Neuhaus, Fabian, Editorial Board Member, Nijhuis, Steffen, Editorial Board Member, Aráujo de Oliveira, Vitor Manuel, Editorial Board Member, Silver, Christopher, Editorial Board Member, Strappa, Giuseppe, Editorial Board Member, Vojnovic, Igor, Editorial Board Member, Yamu, Claudia, Editorial Board Member, Zhao, Qunshan, Editorial Board Member, Carrión Mena, Fernando, editor, and Cepeda Pico, Paulina, editor

Published
2023
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19. Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

Author

Chu, Derek K., Chu, Alexandro W.L., Rayner, Daniel G., Guyatt, Gordon H., Yepes-Nuñez, Juan José, Gomez-Escobar, Luis, Pérez-Herrera, Lucia C., Díaz Martinez, Juan Pablo, Brignardello-Petersen, Romina, Sadeghirad, Behnam, Wong, Melanie M., Ceccacci, Renata, Zhao, Irene X., Basmaji, John, MacDonald, Margaret, Chu, Xiajing, Islam, Nazmul, Gao, Ya, Izcovich, Ariel, Asiniwasis, Rachel N., Boguniewicz, Mark, De Benedetto, Anna, Capozza, Korey, Chen, Lina, Ellison, Kathy, Frazier, Winfred T., Greenhawt, Matthew, Huynh, Joey, LeBovidge, Jennifer, Lio, Peter A., Martin, Stephen A., O’Brien, Monica, Ong, Peck Y., Silverberg, Jonathan I., Spergel, Jonathan M., Smith Begolka, Wendy, Wang, Julie, Wheeler, Kathryn E., Gardner, Donna D., and Schneider, Lynda

Published
2023
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21. Synergistic China–US Ecological Research is Essential for Global Emerging Infectious Disease Preparedness

Author

Smiley Evans, Tierra, Shi, Zhengli, Boots, Michael, Liu, Wenjun, Olival, Kevin J, Xiao, Xiangming, Vandewoude, Sue, Brown, Heidi, Chen, Ji-Long, Civitello, David J, Escobar, Luis, Grohn, Yrjo, Li, Hongying, Lips, Karen, Liu, Qiyoung, Lu, Jiahai, Martínez-López, Beatriz, Shi, Jishu, Shi, Xiaolu, Xu, Biao, Yuan, Lihong, Zhu, Guoqiang, and Getz, Wayne M

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Biological Sciences, Ecology, Prevention, Emerging Infectious Diseases, Clinical Research, Infectious Diseases, Infection, Good Health and Well Being, Animals, Animals, Wild, China, Communicable Diseases, Communicable Diseases, Emerging, Global Health, Humans, International Cooperation, Pandemics, Zoonoses, USA, Emerging infectious diseases, Pandemic, Preparedness, Training, Public Health and Health Services, Veterinary sciences
Abstract

The risk of a zoonotic pandemic disease threatens hundreds of millions of people. Emerging infectious diseases also threaten livestock and wildlife populations around the world and can lead to devastating economic damages. China and the USA-due to their unparalleled resources, widespread engagement in activities driving emerging infectious diseases and national as well as geopolitical imperatives to contribute to global health security-play an essential role in our understanding of pandemic threats. Critical to efforts to mitigate risk is building upon existing investments in global capacity to develop training and research focused on the ecological factors driving infectious disease spillover from animals to humans. International cooperation, particularly between China and the USA, is essential to fully engage the resources and scientific strengths necessary to add this ecological emphasis to the pandemic preparedness strategy. Here, we review the world's current state of emerging infectious disease preparedness, the ecological and evolutionary knowledge needed to anticipate disease emergence, the roles that China and the USA currently play as sources and solutions to mitigating risk, and the next steps needed to better protect the global community from zoonotic disease.

Published
2020

23. Implementation of Collaborative Work Between Two SCARA Robots in a Robotic Cell for Continuous Classification of Products

Author

Córdova, Alexander, Quimbiamba, Paúl, Segura, Luis Javier, Escobar, Luis, Loza, David, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Diaz Cadena, Angela, editor

Published
2022
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24. Design, Construction and Evaluation of a 3DOF Urban Planting System

Author

Paredes, Leonardo, Enríquez, Andrés, Villagran, Nelson, Núñez, Mateo, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Diaz Cadena, Angela, editor

Published
2022
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25. Process Optimization with Discrete Event Simulation Software: An Experience in Ecuador Small Enterprise

Author

Guerrero, Nelson, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2022
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26. Plant Layout Selection Procedure Based on Discrete Event Simulation Software

Author

Cisneros, Darío, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2022
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27. Multi-robot System for Collaborative Work Equipped with Trajectory Planning over IoT Architecture

Author

Guerra, Gabriel, Allauca, Luis, Escobar, Luis, Sánchez-Sánchez, Xavier, Puma-Araujo, Santiago D., Ramirez-Mendoza, Ricardo A., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Moreno, Héctor A., editor, Carrera, Isela G., editor, Ramírez-Mendoza, Ricardo A., editor, Baca, José, editor, and Banfield, Ilka A., editor

Published
2022
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31. Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies

Author

Fountain, Michael D, Oleson, David S, Rech, Megan E, Segebrecht, Lara, Hunter, Jill V, McCarthy, John M, Lupo, Philip J, Holtgrewe, Manuel, Moran, Rocio, Rosenfeld, Jill A, Isidor, Bertrand, Le Caignec, Cédric, Saenz, Margarita S, Pedersen, Robert C, Morgan, Thomas M, Pfotenhauer, Jean P, Xia, Fan, Bi, Weimin, Kang, Sung-Hae L, Patel, Ankita, Krantz, Ian D, Raible, Sarah E, Smith, Wendy, Cristian, Ingrid, Torti, Erin, Juusola, Jane, Millan, Francisca, Wentzensen, Ingrid M, Person, Richard E, Küry, Sébastien, Bézieau, Stéphane, Uguen, Kévin, Férec, Claude, Munnich, Arnold, van Haelst, Mieke, Lichtenbelt, Klaske D, van Gassen, Koen, Hagelstrom, Tanner, Chawla, Aditi, Perry, Denise L, Taft, Ryan J, Jones, Marilyn, Masser-Frye, Diane, Dyment, David, Venkateswaran, Sunita, Li, Chumei, Escobar, Luis F, Horn, Denise, Spillmann, Rebecca C, Peña, Loren, Wierzba, Jolanta, Strom, Tim M, Parenti, Ilaria, Kaiser, Frank J, Ehmke, Nadja, and Schaaf, Christian P

Subjects
Biological Sciences, Genetics, Brain Disorders, Neurosciences, Behavioral and Social Science, Clinical Research, Pediatric, Congenital Structural Anomalies, Intellectual and Developmental Disabilities (IDD), Mental Health, Autism, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Autism Spectrum Disorder, Child, Child, Preschool, Chromosome Deletion, DNA-Binding Proteins, Genome, Human, Haploinsufficiency, Humans, Infant, Infant, Newborn, Intellectual Disability, Language Development Disorders, Neurodevelopmental Disorders, Nuclear Proteins, Phenotype, Problem Behavior, Proteins, Exome Sequencing, USP7, neurodevelopment, speech delay, white matter paucity, corpus callosum thinning, Clinical Sciences, Genetics & Heredity
Abstract

PurposeHaploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism spectrum disorder (ASD), seizures, and hypogonadism. Further, USP7 was identified to critically incorporate into the MAGEL2-USP7-TRIM27 (MUST), such that pathogenic variants in USP7 lead to altered endosomal F-actin polymerization and dysregulated protein recycling.MethodsWe report 16 newly identified individuals with heterozygous USP7 variants, identified by genome or exome sequencing or by chromosome microarray analysis. Clinical features were evaluated by review of medical records. Additional clinical information was obtained on the seven previously reported individuals to fully elucidate the phenotypic expression associated with USP7 haploinsufficiency.ResultsThe clinical manifestations of these 23 individuals suggest a syndrome characterized by DD/ID, hypotonia, eye anomalies,feeding difficulties, GERD, behavioral anomalies, and ASD, and more specific phenotypes of speech delays including a nonverbal phenotype and abnormal brain magnetic resonance image findings including white matter changes based on neuroradiologic examination.ConclusionThe consistency of clinical features among all individuals presented regardless of de novo USP7 variant type supports haploinsufficiency as a mechanism for pathogenesis and refines the clinical impact faced by affected individuals and caregivers.

Published
2019

32. Summary results of the 2014-2015 DARPA Chikungunya challenge

Author

Del Valle, Sara Y, McMahon, Benjamin H, Asher, Jason, Hatchett, Richard, Lega, Joceline C, Brown, Heidi E, Leany, Mark E, Pantazis, Yannis, Roberts, David J, Moore, Sean, Peterson, A Townsend, Escobar, Luis E, Qiao, Huijie, Hengartner, Nicholas W, and Mukundan, Harshini

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Rare Diseases, Vector-Borne Diseases, Prevention, Biodefense, Infectious Diseases, Vaccine Related, Infection, Good Health and Well Being, Chikungunya Fever, Demography, Dengue, Disease Outbreaks, Forecasting, Humans, Infection Control, Organizational Innovation, Research Design, Security Measures, United States, United States Department of Defense, Zika Virus Infection, Chikungunya, Mechanistic models, Morphological models, Microbiology, Medical Microbiology, Clinical sciences, Medical microbiology, Public health
Abstract

BackgroundEmerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are critical to minimizing subsequent mortality, morbidity, and economic loss. The recent introduction of chikungunya and Zika virus to the Americas underscores the need for better methods for disease surveillance and forecasting.MethodsTo explore the suitability of current approaches to forecasting emerging diseases, the Defense Advanced Research Projects Agency (DARPA) launched the 2014-2015 DARPA Chikungunya Challenge to forecast the number of cases and spread of chikungunya disease in the Americas. Challenge participants (n=38 during final evaluation) provided predictions of chikungunya epidemics across the Americas for a six-month period, from September 1, 2014 to February 16, 2015, to be evaluated by comparison with incidence data reported to the Pan American Health Organization (PAHO). This manuscript presents an overview of the challenge and a summary of the approaches used by the winners.ResultsParticipant submissions were evaluated by a team of non-competing government subject matter experts based on numerical accuracy and methodology. Although this manuscript does not include in-depth analyses of the results, cursory analyses suggest that simpler models appear to outperform more complex approaches that included, for example, demographic information and transportation dynamics, due to the reporting biases, which can be implicitly captured in statistical models. Mosquito-dynamics, population specific information, and dengue-specific information correlated best with prediction accuracy.ConclusionWe conclude that with careful consideration and understanding of the relative advantages and disadvantages of particular methods, implementation of an effective prediction system is feasible. However, there is a need to improve the quality of the data in order to more accurately predict the course of epidemics.

Published
2018

33. The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels

Author

Romanello, Marina, Di Napoli, Claudia, Drummond, Paul, Green, Carole, Kennard, Harry, Lampard, Pete, Scamman, Daniel, Arnell, Nigel, Ayeb-Karlsson, Sonja, Ford, Lea Berrang, Belesova, Kristine, Bowen, Kathryn, Cai, Wenjia, Callaghan, Max, Campbell-Lendrum, Diarmid, Chambers, Jonathan, van Daalen, Kim R, Dalin, Carole, Dasandi, Niheer, Dasgupta, Shouro, Davies, Michael, Dominguez-Salas, Paula, Dubrow, Robert, Ebi, Kristie L, Eckelman, Matthew, Ekins, Paul, Escobar, Luis E, Georgeson, Lucien, Graham, Hilary, Gunther, Samuel H, Hamilton, Ian, Hang, Yun, Hänninen, Risto, Hartinger, Stella, He, Kehan, Hess, Jeremy J, Hsu, Shih-Che, Jankin, Slava, Jamart, Louis, Jay, Ollie, Kelman, Ilan, Kiesewetter, Gregor, Kinney, Patrick, Kjellstrom, Tord, Kniveton, Dominic, Lee, Jason K W, Lemke, Bruno, Liu, Yang, Liu, Zhao, Lott, Melissa, Batista, Martin Lotto, Lowe, Rachel, MacGuire, Frances, Sewe, Maquins Odhiambo, Martinez-Urtaza, Jaime, Maslin, Mark, McAllister, Lucy, McGushin, Alice, McMichael, Celia, Mi, Zhifu, Milner, James, Minor, Kelton, Minx, Jan C, Mohajeri, Nahid, Moradi-Lakeh, Maziar, Morrissey, Karyn, Munzert, Simon, Murray, Kris A, Neville, Tara, Nilsson, Maria, Obradovich, Nick, O'Hare, Megan B, Oreszczyn, Tadj, Otto, Matthias, Owfi, Fereidoon, Pearman, Olivia, Rabbaniha, Mahnaz, Robinson, Elizabeth J Z, Rocklöv, Joacim, Salas, Renee N, Semenza, Jan C, Sherman, Jodi D, Shi, Liuhua, Shumake-Guillemot, Joy, Silbert, Grant, Sofiev, Mikhail, Springmann, Marco, Stowell, Jennifer, Tabatabaei, Meisam, Taylor, Jonathon, Triñanes, Joaquin, Wagner, Fabian, Wilkinson, Paul, Winning, Matthew, Yglesias-González, Marisol, Zhang, Shihui, Gong, Peng, Montgomery, Hugh, and Costello, Anthony

Published
2022
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34. Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients

Author

Torres, Rubén, Toro, Luis, Sanhueza, María Eugenia, Lorca, Eduardo, Ortiz, Mireya, Pefaur, Jacqueline, Clavero, Rene, Machuca, Eduardo, Gonzalez, Fernando, Herrera, Patricia, Mocarquer, Alfredo, Frias, Alondra, Roessler, Eric, Muñoz, Carolina, Nuñez, Miguel, Aravena, Cesar, Quintana, Enrique, Lemus, Juan, Lillo, Mario, Reynolds, Enrique, Morales, Alvaro, Pais, Edgard, Fiabane, Andrea, Parra-Lucares, Alfredo, Garrido, Cristian, Mendez-Valdes, Gabriel, Villa, Eduardo, Mansilla, Rodrigo, Sotomayor, Germana, Gonzalez, Marcela, Miranda, Cecilia, Briones, Eduardo, Gomez, Esteban, Mezzano, Sergio, Bernales, Waldo, Rocca, Ximena, Espinoza, Oscar, Zuñiga, Eric, Aragon, Henry, Badilla, Marta, Valenzuela, Marcela, Escobar, Luis, Zamora, Daniela, Flores, Ivan, Tapia, Beatriz, Borquez, Tamara, and Herrera, Patricio

Published
2022
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35. Surgeons' Recommendations for Neurodiagnostic Testing With High Pretest Probability of Idiopathic Median Neuropathy at the Carpal Tunnel

Author

Adams, Julie E., Adolfsson, Lars E., Apard, Thomas, Ashmead, Duffield, Bainbridge, L. Christopher, Bamberger, Hugh Brent, Baxamusa, Taizoon, Buendia, Luis A., Butters, Kenneth, Cagnone, Juan Carlos, Calcagni, Maurizio, Carpeggiani, Guilherme, Casstevens, Chritopher E., Chivers, Kevin, de Bedout, Ramon, Dwyer, C. Liam, Erickson, John M., Erol, Kent, Evans, Peter J., Falcon, Daniel, Farr, Sebastian, Fernandes, Carlos Henrique, Fischer, Thomas J., Gilbert, Richard S., Gire, Jacob D., Giuffrida, Angela Ylenia, Gosens, Taco, Grafe, Michael W., Gray, Robert R.L., Greenberg, Jeffrey A., Guitton, Thierry G., Hammert, Warren C., Hearon, Bernard F., Henry, Steven L., Hofmeister, Eric P., Huang, Jerry I., Ibrahim, Eric F., Jebson, Peter, Kakar, Sanjeev, Kaplan, F. Thomas D., Kennedy, Stephen A., Ko, Jason H., Kronlage, Steven, Lee, Kenneth E., Marcus, Alexander M., McAuliffe, John A., Mitchell, Stephen, Moreno-Serrano, Constanza Lucia, Nancollas, Michael P., Napoli, David C., Nappi, James F., Naquira Escobar, Luis Felipe, Nolan, Betsy M., Ortiz, Jose A., II, Paladini, Paolo, Palmer, Bradley A., Palmer, Michael Jason, Parnes, Nata, Patiño, Juan Martin, Patterson, D. Paul, Pianka, George, Pirela Cruz, Miguel A., Platz, Andreas, Polatsch, Daniel, Richardson, Mark, Ruch, David, Rumball, Kevin M., Samora, Julie B., Satteson, Ellen S., Schumer, Evan D., Shafritz, Adam B., Siff, Todd, Sitaram, Prasad, Souer, J. Sebastiaan, Spaans, Anne, Sutker, Benjamin, Talsania, Jay, Tavakolian, Jason D., Terrono, Andrew L., van der Pluijm, Marco, van Riet, Roger, Vochteloo, Ali J., Walbeehm, Ryan P., Walsh, Christopher J., Weiss, Lawrence, Willems, W. Jaap, Wills, Brian P.D., Wint, Jeffrey, Wood, Megan M., Zalavras, Charalampos, Zeltser, David W., Crijns, Tom Joris, Mucharraz, Carlos, Paravasthuramesh, Abinaya, Teunis, Teun, Ring, David, and Fatehi, Amirreza

Published
2022
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36. Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19

Author

Buyukozkan, Mustafa, Alvarez-Mulett, Sergio, Racanelli, Alexandra C., Schmidt, Frank, Batra, Richa, Hoffman, Katherine L., Sarwath, Hina, Engelke, Rudolf, Gomez-Escobar, Luis, Simmons, Will, Benedetti, Elisa, Chetnik, Kelsey, Zhang, Guoan, Schenck, Edward, Suhre, Karsten, Choi, Justin J., Zhao, Zhen, Racine-Brzostek, Sabrina, Yang, He S., Choi, Mary E., Choi, Augustine M.K., Cho, Soo Jung, and Krumsiek, Jan

Published
2022
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37. Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Price, David R., Benedetti, Elisa, Hoffman, Katherine L., Gomez-Escobar, Luis, Alvarez-Mulett, Sergio, Capili, Allyson, Sarwath, Hina, Parkhurst, Christopher N., Lafond, Elyse, Weidman, Karissa, Ravishankar, Arjun, Cheong, Jin Gyu, Batra, Richa, Büyüközkan, Mustafa, Chetnik, Kelsey, Easthausen, Imaani, Schenck, Edward J., Racanelli, Alexandra C., Outtz Reed, Hasina, Laurence, Jeffrey, Josefowicz, Steven Z., Lief, Lindsay, Choi, Mary E., Schmidt, Frank, Borczuk, Alain C., Choi, Augustine M.K., Krumsiek, Jan, and Rafii, Shahin

Published
2022
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40. Tracking the impacts of climate change on human health via indicators: lessons from the Lancet Countdown

Author

Di Napoli, Claudia, McGushin, Alice, Romanello, Marina, Ayeb-Karlsson, Sonja, Cai, Wenjia, Chambers, Jonathan, Dasgupta, Shouro, Escobar, Luis E., Kelman, Ilan, Kjellstrom, Tord, Kniveton, Dominic, Liu, Yang, Liu, Zhao, Lowe, Rachel, Martinez-Urtaza, Jaime, McMichael, Celia, Moradi-Lakeh, Maziar, Murray, Kris A., Rabbaniha, Mahnaz, Semenza, Jan C., Shi, Liuhua, Tabatabaei, Meisam, Trinanes, Joaquin A., Vu, Bryan N., Brimicombe, Chloe, and Robinson, Elizabeth J.

Published
2022
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41. A database of common vampire bat reports

Author

Van de Vuurst, Paige, Díaz, M. Mónica, Rodríguez-San Pedro, Annia, Allendes, Juan Luis, Brown, Natalie, Gutiérrez, Juan David, Zarza, Heliot, de Oliveira, Stefan V., Cárdenas-Canales, Elsa, Barquez, Rubén M., and Escobar, Luis E.

Published
2022
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42. Kidney Recovery and Death in Critically Ill Patients With COVID-19–Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study

Author

Gupta, Hsu, Faugno, Goyal, Raichoudhury, Tariq, Meyer, Sharma, Leaf, Kshirsagar, Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Bauer, Kenneth A., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, WilliamsSamantha K. Brenner, Aquino, Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Tehranian, Shahrzad, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns. Ryan Mocerino, Tanya S., Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Thakkar, Jyotsana, Kumar, Neelja, Ross, Michael J., Chang, Michael, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner M.B., Avasare, Rupali S., Zonies, David, Al-Samkari, Hanny, Leaf, Rebecca Karp, Rosovsky, Rachel, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Karp, George, Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Sharshir, Moh’d A., Rusnak, Vadym V., Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, RheeKa, Harin, thleen D. Liu, Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Dy, Rajany, Iardino, Alfredo, Au, Elizabeth H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Fornoni, Alessia, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Chugh, Savneek, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Hsu, Caroline M., Gupta, Shruti, Tighiouart, Hocine, Goyal, Nitender, Faugno, Anthony J., Tariq, Asma, Raichoudhury, Ritesh, Sharma, Jill H., Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Leaf, David E., and Weiner, Daniel E.

Published
2022
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43. Climate change linked to vampire bat expansion and rabies virus spillover.

Author

Van de Vuurst, Paige, Qiao, Huijie, Soler‐Tovar, Diego, and Escobar, Luis E.

Subjects
SARS disease, EMERGING infectious diseases, BAT ecology, NIPAH virus, TROPICAL ecosystems, RABIES virus
Abstract

Bat‐borne pathogens are a threat to global health and in recent history have had major impacts on human morbidity and mortality. Examples include diseases such as rabies, Nipah virus encephalitis, and severe acute respiratory syndrome (SARS). Climate change may exacerbate the emergence of bat‐borne pathogens by affecting the ecology of bats in tropical ecosystems. Here, we report the impacts of climate change on the distributional ecology of the common vampire bat Desmodus rotundus across the last century. Our retrospective analysis revealed a positive relationship between changes in climate and the northern expansion of the distribution of D. rotundus in North America. Furthermore, we also found a reduction in the standard deviation of temperatures at D. rotundus capture locations during the last century, expressed as more consistent, less‐seasonal climate in recent years. These results elucidate an association between D. rotundus range expansion and a continental‐level rise in rabies virus spillover transmission from D. rotundus to cattle in the last 50 years of the 120‐year study period. This correlative study, based on field observations, offers empirical evidence supporting previous statistical and mathematical simulation‐based studies reporting a likely increase of bat‐borne diseases in response to climate change. We conclude that the D. rotundus rabies system exemplifies the consequences of climate change augmentation at the wildlife–livestock–human interface, demonstrating how global change acts upon these complex and interconnected systems to drive increased disease emergence. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Covalent Linkages Used in Prebiotic Chemistry for RNA‐Templated Amino Acid Transfer and Peptide Synthesis.

Author

Escobar, Luis

Abstract

Biological translation is a universal process taking place in the ribosome. It involves the synthesis of a protein with a particular sequence from the information encoded in a messenger RNA and the amino acids carried by transfer RNAs with the assistance of specific enzymes. However, the origin of translation in the prebiotic world and, thus, in the absence of enzymes is difficult to envisage. Past and recent studies proposed different prebiotic models, following top‐down and bottom‐up approaches, for the origin and evolution of a primitive ribosome. The bottom‐up models made use of distinct covalent linkages to connect RNA strands with amino acids and peptides. In this review, I focus on the covalent linkages used in these prebiotic models: acyl phosphate mixed anhydrides, phosphoramidates and ureas. I describe their syntheses under prebiotically plausible reaction conditions, as well as include their main conventional preparation methods. I also comment on their properties and chemical stabilities in aqueous solution. Finally, I examine the functions of the described covalent linkages in prebiotic processes involving RNA‐templated amino acid transfer and peptide synthesis. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Flexible Manufacturing Systems Optimization with Meta-heuristic Algorithm Using Open Source Software

Author

Izquierdo, Fabian, Garcia, Edwin, Cortez, Byron, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Botto Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2021
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46. YaniWawa: An Innovative Tool for Teaching Using Programmable Models over Augmented Reality Sandbox

Author

Cárdenas-Delgado, Sonia, Padilla Almeida, Oswaldo, Loachamín-Valencia, Mauricio, Rivera, Henry, Escobar, Luis, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Botto-Tobar, Miguel, editor, Zamora, Willian, editor, Larrea Plúa, Johnny, editor, Bazurto Roldan, José, editor, and Santamaría Philco, Alex, editor

Published
2021
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47. Imposter Syndrome Among Surgeons Is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving

Author

Lin, Eugenia, Crijns, Tom J., Ring, David, Jayakumar, Prakash, Cruz, Miguel Pirela, Kraan, Gerald A., Muhl, Philipp, Gilbert, Richard S., Siff, Todd, Spaans, Anne, Shafritz, Adam, Adams, Julie, Vochteloo, Anne J.H., Platz, Andreas, Terrono, Andrew L., Bafus, Todd, Bamberger, H. Brent, Sutker, Ben, Hearon, Bernard F., Braman, Jonathan, Calfee, Ryan P., Ekholm, Carl, Fernandes, Carlos H., Metzger, Charles, Bainbridge, Chris, Moreno-Serrano, Constanza L., Ashmead, Duffield, IV, Drosdowech, Darren, McKee, Desirae M., Falcon, Daniel, Polatsch, Dan, Patterson, David P., Romero Barreto, Camilo Jose, Shafi, Mohamed, Patiño, Juan M., van Riet, Roger, Raven, Eric, Satteson, Ellen, Walbeehm, Erik T., Schumer, Evan D., Zaidenberg, Ezequiel E., Suarez, Fabio, OʼBrien, Fred, Verstreken, Frederik, Pianka, George, Bayne, Grant, Fierro, Guido, Guitton, Thierry G., Nancollas, Michael, Greenberg, Jeffrey A., Watchmaker, Greg P., Lane, Lewis B., Hofmeister, Eric P., Kazanjian, Jack E., Brubacher, Jacob W., Gire, Jacob, Tavakolian, Jason D., Nappi, James F., Erickson, John M., Taras, John, Samora, Julie Balch, Kakar, Sanjeev, Butters, Ken, Lee, Kendrick E., Rumball, Kevin, Weiss, Lawrence, Adolfsson, Lars, Dwyer, C. Liam, Naquira Escobar, Luis F., van der Pluijm, Marco, Richard, Marc J., Calcagni, Maurizio, McAuliffe, John A., Ruiz-Suarez, Michell, Palmer, Michael J., Grafe, Michael W., Akabudike, Ngozi M., Hoekzema, Nathan A., Richardson, Martin, Ortiz, Jose A., Jr, Johnson, Jeff W., Benhaim, Prosper, Blazar, Philip, Jebson, Peter, Owens, Patrick W., Walbeehm, Ralf, de Bedout, Ramon, Shatford, Russell, Rowinski, Sergio, Wallensten, Richard, Rodner, Craig, Sabesan, Vani J., Kennedy, Stephen A., Nolan, Betsy M., Kronlage, Steve, Souer, Sebastiaan, Henry, Steven L., Gosens, Taco, Baxamusa, Taizoon, Kaplan, F. Thomas D., Apard, Thomas, Willems, W. Jaap, Hammert, Warren C., and Waseem, Mohammad

Published
2023
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48. Imposter Syndrome Among Surgeons Is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving

Author

Lin, Eugenia, Crijns, Tom J., Ring, David, Jayakumar, Prakash, Cruz, Miguel Pirela, Kraan, Gerald A., Muhl, Philipp, Gilbert, Richard S., Siff, Todd, Spaans, Anne, Shafritz, Adam, Adams, Julie, Vochteloo, Anne J.H., Platz, Andreas, Terrono, Andrew L., Bafus, Todd, Bamberger, H. Brent, Sutker, Ben, Hearon, Bernard F., Braman, Jonathan, Calfee, Ryan P., Ekholm, Carl, Fernandes, Carlos H., Metzger, Charles, Bainbridge, Chris, Moreno-Serrano, Constanza L., Ashmead, Duffield, IV, Drosdowech, Darren, McKee, Desirae M., Falcon, Daniel, Polatsch, Dan, Patterson, David P., Romero Barreto, Camilo Jose, Shafi, Mohamed, Patiño, Juan M., van Riet, Roger, Raven, Eric, Satteson, Ellen, Walbeehm, Erik T., Schumer, Evan D., Zaidenberg, Ezequiel E., Suarez, Fabio, OʼBrien, Fred, Verstreken, Frederik, Pianka, George, Bayne, Grant, Fierro, Guido, Guitton, Thierry G., Nancollas, Michael, Greenberg, Jeffrey A., Watchmaker, Greg P., Lane, Lewis B., Hofmeister, Eric P., Kazanjian, Jack E., Brubacher, Jacob W., Gire, Jacob, Tavakolian, Jason D., Nappi, James F., Erickson, John M., Taras, John, Samora, Julie Balch, Kakar, Sanjeev, Butters, Ken, Lee, Kendrick E., Rumball, Kevin, Weiss, Lawrence, Adolfsson, Lars, Dwyer, C. Liam, Naquira Escobar, Luis F., van der Pluijm, Marco, Richard, Marc J., Calcagni, Maurizio, McAuliffe, John A., Ruiz-Suarez, Michell, Palmer, Michael J., Grafe, Michael W., Akabudike, Ngozi M., Hoekzema, Nathan A., Richardson, Martin, Ortiz, Jose A., Jr, Johnson, Jeff W., Benhaim, Prosper, Blazar, Philip, Jebson, Peter, Owens, Patrick W., Walbeehm, Ralf, de Bedout, Ramon, Shatford, Russell, Rowinski, Sergio, Wallensten, Richard, Rodner, Craig, Sabesan, Vani J., Kennedy, Stephen A., Nolan, Betsy M., Kronlage, Steve, Souer, Sebastiaan, Henry, Steven L., Gosens, Taco, Baxamusa, Taizoon, Kaplan, F. Thomas D., Apard, Thomas, Willems, W. Jaap, Hammert, Warren C., and Waseem, Mohammad

Published
2022
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50. Back to the future for drought tolerance

Author

Guadarrama‐Escobar, Luis M., primary, Hunt, James, additional, Gurung, Allison, additional, Zarco‐Tejada, Pablo J., additional, Shabala, Sergey, additional, Camino, Carlos, additional, Hernandez, Pilar, additional, and Pourkheirandish, Mohammad, additional

Published
2024
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