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1. On Equivalence of Likelihood-Based Confidence Bands for Fatigue-Life and Fatigue-Strength Distributions

Author

Liu, Peng, Hong, Yili, Escobar, Luis A., and Meeker, William Q.

Subjects
Statistics - Methodology, Mathematics - Statistics Theory
Abstract

Fatigue data arise in many research and applied areas and there have been statistical methods developed to model and analyze such data. The distributions of fatigue life and fatigue strength are often of interest to engineers designing products that might fail due to fatigue from cyclic-stress loading. Based on a specified statistical model and the maximum likelihood method, the cumulative distribution function (cdf) and quantile function (qf) can be estimated for the fatigue-life and fatigue-strength distributions. Likelihood-based confidence bands then can be obtained for the cdf and qf. This paper provides equivalence results for confidence bands for fatigue-life and fatigue-strength models. These results are useful for data analysis and computing implementation. We show (a) the equivalence of the confidence bands for the fatigue-life cdf and the fatigue-life qf, (b) the equivalence of confidence bands for the fatigue-strength cdf and the fatigue-strength qf, and (c) the equivalence of confidence bands for the fatigue-life qf and the fatigue-strength qf. Then we illustrate the usefulness of those equivalence results with two examples using experimental fatigue data.

Published
2024

5. Modern Statistical Models and Methods for Estimating Fatigue-Life and Fatigue-Strength Distributions from Experimental Data

Author

Meeker, William Q., Escobar, Luis A., Pascual, Francis G., Hong, Yili, Liu, Peng, Falk, Wayne M., and Ananthasayanam, Balajee

Subjects
Statistics - Methodology
Abstract

Engineers and scientists have been collecting and analyzing fatigue data since the 1800s to ensure the reliability of life-critical structures. Applications include (but are not limited to) bridges, building structures, aircraft and spacecraft components, ships, ground-based vehicles, and medical devices. Engineers need to estimate S-N relationships (Stress or Strain versus Number of cycles to failure), typically with a focus on estimating small quantiles of the fatigue-life distribution. Estimates from this kind of model are used as input to models (e.g., cumulative damage models) that predict failure-time distributions under varying stress patterns. Also, design engineers need to estimate lower-tail quantiles of the closely related fatigue-strength distribution. The history of applying incorrect statistical methods is nearly as long and such practices continue to the present. Examples include treating the applied stress (or strain) as the response and the number of cycles to failure as the explanatory variable in regression analyses (because of the need to estimate strength distributions) and ignoring or otherwise mishandling censored observations (known as runouts in the fatigue literature). The first part of the paper reviews the traditional modeling approach where a fatigue-life model is specified. We then show how this specification induces a corresponding fatigue-strength model. The second part of the paper presents a novel alternative modeling approach where a fatigue-strength model is specified and a corresponding fatigue-life model is induced. We explain and illustrate the important advantages of this new modeling approach., Comment: 82 pages, 30 figures. Made some minor revision and reduced the appendix

Published
2022

7. The 2023 Latin America report of the Lancet Countdown on health and climate change: the imperative for health-centred climate-resilient development

Author

Hartinger, Stella M., Palmeiro-Silva, Yasna K., Llerena-Cayo, Camila, Blanco-Villafuerte, Luciana, Escobar, Luis E., Diaz, Avriel, Sarmiento, Juliana Helo, Lescano, Andres G., Melo, Oscar, Rojas-Rueda, David, Takahashi, Bruno, Callaghan, Max, Chesini, Francisco, Dasgupta, Shouro, Posse, Carolina Gil, Gouveia, Nelson, Martins de Carvalho, Aline, Miranda-Chacón, Zaray, Mohajeri, Nahid, Pantoja, Chrissie, Robinson, Elizabeth J.Z., Salas, Maria Fernanda, Santiago, Raquel, Sauma, Enzo, Santos-Vega, Mauricio, Scamman, Daniel, Sergeeva, Milena, Souza de Camargo, Tatiana, Sorensen, Cecilia, Umaña, Juan D., Yglesias-González, Marisol, Walawender, Maria, Buss, Daniel, and Romanello, Marina

Published
2024
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13. ENM2020: A Free Online Course and Set of Resources on Modeling Species' Niches and Distributions

Author

Peterson, A Townsend, Aiello-Lammens, Matthew, Amatulli, Giuseppe, Anderson, Robert, Cobos, Marlon, Diniz-Filho, José Alexandre, Escobar, Luis, Feng, Xiao, Franklin, Janet, Gadelha, Luiz, Georges, Damien, Guéguen, M, Gueta, Tomer, Ingenloff, Kate, Jarvie, Scott, Jiménez, Laura, Karger, Dirk, Kass, Jamie, Kearney, Michael, Loyola, Rafael, Machado-Stredel, Fernando, Martínez-Meyer, Enrique, Merow, Cory, Mondelli, Maria Luiza, Mortara, Sara, Muscarella, Robert, Myers, Corinne, Naimi, Babak, Noesgaard, Daniel, Ondo, Ian, Osorio-Olvera, Luis, Owens, Hannah, Pearson, Richard, Pinilla-Buitrago, Gonzalo, Sánchez-Tapia, Andrea, Saupe, Erin, Thuiller, Wilfried, Varela, Sara, Warren, Dan, Wieczorek, John, Yates, Katherine, Zhu, Gengping, Zuquim, Gabriela, and Zurell, Damaris

Subjects
Ecological niche model, Species distribution model, Course, Open access, Methods
Abstract

The field of distributional ecology has seen considerable recent attention, particularly surrounding the theory, protocols, and tools for Ecological Niche Modeling (ENM) or Species Distribution Modeling (SDM). Such analyses have grown steadily over the past two decades—including a maturation of relevant theory and key concepts—but methodological consensus has yet to be reached. In response, and following an online course taught in Spanish in 2018, we designed a comprehensive English-language course covering much of the underlying theory and methods currently applied in this broad field. Here, we summarize that course, ENM2020, and provide links by which resources produced for it can be accessed into the future. ENM2020 lasted 43 weeks, with presentations from 52 instructors, who engaged with >2500 participants globally through >14,000 hours of viewing and >90,000 views of instructional video and question-and-answer sessions. Each major topic was introduced by an “Overview” talk, followed by more detailed lectures on subtopics. The hierarchical and modular format of the course permits updates, corrections, or alternative viewpoints, and generally facilitates revision and reuse, including the use of only the Overview lectures for introductory courses. All course materials are free and openly accessible (CC-BY license) to ensure these resources remain available to all interested in distributional ecology.

Published
2022

14. The Implosion of Memory. City and Drug Trafficking in Medellín and the Aburrá Valley

Author

González Escobar, Luis Fernando, Angelidou, Margarita, Editorial Board Member, Farnaz Arefian, Fatemeh, Editorial Board Member, Batty, Michael, Editorial Board Member, Davoudi, Simin, Editorial Board Member, DeVerteuil, Geoffrey, Editorial Board Member, González Pérez, Jesús M., Editorial Board Member, Hess, Daniel B., Editorial Board Member, Jones, Paul, Editorial Board Member, Karvonen, Andrew, Editorial Board Member, Kirby, Andrew, Editorial Board Member, Kropf, Karl, Editorial Board Member, Lucas, Karen, Editorial Board Member, Maretto, Marco, Editorial Board Member, Modarres, Ali, Editorial Board Member, Neuhaus, Fabian, Editorial Board Member, Nijhuis, Steffen, Editorial Board Member, Aráujo de Oliveira, Vitor Manuel, Editorial Board Member, Silver, Christopher, Editorial Board Member, Strappa, Giuseppe, Editorial Board Member, Vojnovic, Igor, Editorial Board Member, Yamu, Claudia, Editorial Board Member, Zhao, Qunshan, Editorial Board Member, Carrión Mena, Fernando, editor, and Cepeda Pico, Paulina, editor

Published
2023
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16. Genotype–phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders

Author

Mannucci, Ilaria, Dang, Nghi DP, Huber, Hannes, Murry, Jaclyn B, Abramson, Jeff, Althoff, Thorsten, Banka, Siddharth, Baynam, Gareth, Bearden, David, Beleza-Meireles, Ana, Benke, Paul J, Berland, Siren, Bierhals, Tatjana, Bilan, Frederic, Bindoff, Laurence A, Braathen, Geir Julius, Busk, Øyvind L, Chenbhanich, Jirat, Denecke, Jonas, Escobar, Luis F, Estes, Caroline, Fleischer, Julie, Groepper, Daniel, Haaxma, Charlotte A, Hempel, Maja, Holler-Managan, Yolanda, Houge, Gunnar, Jackson, Adam, Kellogg, Laura, Keren, Boris, Kiraly-Borri, Catherine, Kraus, Cornelia, Kubisch, Christian, Le Guyader, Gwenael, Ljungblad, Ulf W, Brenman, Leslie Manace, Martinez-Agosto, Julian A, Might, Matthew, Miller, David T, Minks, Kelly Q, Moghaddam, Billur, Nava, Caroline, Nelson, Stanley F, Parant, John M, Prescott, Trine, Rajabi, Farrah, Randrianaivo, Hanitra, Reiter, Simone F, Schuurs-Hoeijmakers, Janneke, Shieh, Perry B, Slavotinek, Anne, Smithson, Sarah, Stegmann, Alexander PA, Tomczak, Kinga, Tveten, Kristian, Wang, Jun, Whitlock, Jordan H, Zweier, Christiane, McWalter, Kirsty, Juusola, Jane, Quintero-Rivera, Fabiola, Fischer, Utz, Yeo, Nan Cher, Kreienkamp, Hans-Jürgen, and Lessel, Davor

Subjects
Biological Sciences, Genetics, Pediatric, Clinical Research, Mental Health, Prevention, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Animals, Biomarkers, Gene Expression, Gene Knockdown Techniques, Genetic Association Studies, Genetic Predisposition to Disease, Germ-Line Mutation, HEK293 Cells, Humans, Immunohistochemistry, Mutation, Neurodevelopmental Disorders, Phenotype, RNA Helicases, Zebrafish, Clinical Sciences
Abstract

BackgroundWe aimed to define the clinical and variant spectrum and to provide novel molecular insights into the DHX30-associated neurodevelopmental disorder.MethodsClinical and genetic data from affected individuals were collected through Facebook-based family support group, GeneMatcher, and our network of collaborators. We investigated the impact of novel missense variants with respect to ATPase and helicase activity, stress granule (SG) formation, global translation, and their effect on embryonic development in zebrafish. SG formation was additionally analyzed in CRISPR/Cas9-mediated DHX30-deficient HEK293T and zebrafish models, along with in vivo behavioral assays.ResultsWe identified 25 previously unreported individuals, ten of whom carry novel variants, two of which are recurrent, and provide evidence of gonadal mosaicism in one family. All 19 individuals harboring heterozygous missense variants within helicase core motifs (HCMs) have global developmental delay, intellectual disability, severe speech impairment, and gait abnormalities. These variants impair the ATPase and helicase activity of DHX30, trigger SG formation, interfere with global translation, and cause developmental defects in a zebrafish model. Notably, 4 individuals harboring heterozygous variants resulting either in haploinsufficiency or truncated proteins presented with a milder clinical course, similar to an individual harboring a de novo mosaic HCM missense variant. Functionally, we established DHX30 as an ATP-dependent RNA helicase and as an evolutionary conserved factor in SG assembly. Based on the clinical course, the variant location, and type we establish two distinct clinical subtypes. DHX30 loss-of-function variants cause a milder phenotype whereas a severe phenotype is caused by HCM missense variants that, in addition to the loss of ATPase and helicase activity, lead to a detrimental gain-of-function with respect to SG formation. Behavioral characterization of dhx30-deficient zebrafish revealed altered sleep-wake activity and social interaction, partially resembling the human phenotype.ConclusionsOur study highlights the usefulness of social media to define novel Mendelian disorders and exemplifies how functional analyses accompanied by clinical and genetic findings can define clinically distinct subtypes for ultra-rare disorders. Such approaches require close interdisciplinary collaboration between families/legal representatives of the affected individuals, clinicians, molecular genetics diagnostic laboratories, and research laboratories.

Published
2021

18. Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

Author

Chu, Derek K., Chu, Alexandro W.L., Rayner, Daniel G., Guyatt, Gordon H., Yepes-Nuñez, Juan José, Gomez-Escobar, Luis, Pérez-Herrera, Lucia C., Díaz Martinez, Juan Pablo, Brignardello-Petersen, Romina, Sadeghirad, Behnam, Wong, Melanie M., Ceccacci, Renata, Zhao, Irene X., Basmaji, John, MacDonald, Margaret, Chu, Xiajing, Islam, Nazmul, Gao, Ya, Izcovich, Ariel, Asiniwasis, Rachel N., Boguniewicz, Mark, De Benedetto, Anna, Capozza, Korey, Chen, Lina, Ellison, Kathy, Frazier, Winfred T., Greenhawt, Matthew, Huynh, Joey, LeBovidge, Jennifer, Lio, Peter A., Martin, Stephen A., O’Brien, Monica, Ong, Peck Y., Silverberg, Jonathan I., Spergel, Jonathan M., Smith Begolka, Wendy, Wang, Julie, Wheeler, Kathryn E., Gardner, Donna D., and Schneider, Lynda

Published
2023
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20. Synergistic China–US Ecological Research is Essential for Global Emerging Infectious Disease Preparedness

Author

Smiley Evans, Tierra, Shi, Zhengli, Boots, Michael, Liu, Wenjun, Olival, Kevin J, Xiao, Xiangming, Vandewoude, Sue, Brown, Heidi, Chen, Ji-Long, Civitello, David J, Escobar, Luis, Grohn, Yrjo, Li, Hongying, Lips, Karen, Liu, Qiyoung, Lu, Jiahai, Martínez-López, Beatriz, Shi, Jishu, Shi, Xiaolu, Xu, Biao, Yuan, Lihong, Zhu, Guoqiang, and Getz, Wayne M

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Biological Sciences, Ecology, Prevention, Emerging Infectious Diseases, Clinical Research, Infectious Diseases, Infection, Good Health and Well Being, Animals, Animals, Wild, China, Communicable Diseases, Communicable Diseases, Emerging, Global Health, Humans, International Cooperation, Pandemics, Zoonoses, USA, Emerging infectious diseases, Pandemic, Preparedness, Training, Public Health and Health Services, Veterinary sciences
Abstract

The risk of a zoonotic pandemic disease threatens hundreds of millions of people. Emerging infectious diseases also threaten livestock and wildlife populations around the world and can lead to devastating economic damages. China and the USA-due to their unparalleled resources, widespread engagement in activities driving emerging infectious diseases and national as well as geopolitical imperatives to contribute to global health security-play an essential role in our understanding of pandemic threats. Critical to efforts to mitigate risk is building upon existing investments in global capacity to develop training and research focused on the ecological factors driving infectious disease spillover from animals to humans. International cooperation, particularly between China and the USA, is essential to fully engage the resources and scientific strengths necessary to add this ecological emphasis to the pandemic preparedness strategy. Here, we review the world's current state of emerging infectious disease preparedness, the ecological and evolutionary knowledge needed to anticipate disease emergence, the roles that China and the USA currently play as sources and solutions to mitigating risk, and the next steps needed to better protect the global community from zoonotic disease.

Published
2020

21. Implementation of Collaborative Work Between Two SCARA Robots in a Robotic Cell for Continuous Classification of Products

Author

Córdova, Alexander, Quimbiamba, Paúl, Segura, Luis Javier, Escobar, Luis, Loza, David, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Diaz Cadena, Angela, editor

Published
2022
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22. Design, Construction and Evaluation of a 3DOF Urban Planting System

Author

Paredes, Leonardo, Enríquez, Andrés, Villagran, Nelson, Núñez, Mateo, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Diaz Cadena, Angela, editor

Published
2022
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23. Process Optimization with Discrete Event Simulation Software: An Experience in Ecuador Small Enterprise

Author

Guerrero, Nelson, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2022
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24. Plant Layout Selection Procedure Based on Discrete Event Simulation Software

Author

Cisneros, Darío, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Botto-Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2022
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25. Multi-robot System for Collaborative Work Equipped with Trajectory Planning over IoT Architecture

Author

Guerra, Gabriel, Allauca, Luis, Escobar, Luis, Sánchez-Sánchez, Xavier, Puma-Araujo, Santiago D., Ramirez-Mendoza, Ricardo A., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Moreno, Héctor A., editor, Carrera, Isela G., editor, Ramírez-Mendoza, Ricardo A., editor, Baca, José, editor, and Banfield, Ilka A., editor

Published
2022
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31. The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels

Author

Romanello, Marina, Di Napoli, Claudia, Drummond, Paul, Green, Carole, Kennard, Harry, Lampard, Pete, Scamman, Daniel, Arnell, Nigel, Ayeb-Karlsson, Sonja, Ford, Lea Berrang, Belesova, Kristine, Bowen, Kathryn, Cai, Wenjia, Callaghan, Max, Campbell-Lendrum, Diarmid, Chambers, Jonathan, van Daalen, Kim R, Dalin, Carole, Dasandi, Niheer, Dasgupta, Shouro, Davies, Michael, Dominguez-Salas, Paula, Dubrow, Robert, Ebi, Kristie L, Eckelman, Matthew, Ekins, Paul, Escobar, Luis E, Georgeson, Lucien, Graham, Hilary, Gunther, Samuel H, Hamilton, Ian, Hang, Yun, Hänninen, Risto, Hartinger, Stella, He, Kehan, Hess, Jeremy J, Hsu, Shih-Che, Jankin, Slava, Jamart, Louis, Jay, Ollie, Kelman, Ilan, Kiesewetter, Gregor, Kinney, Patrick, Kjellstrom, Tord, Kniveton, Dominic, Lee, Jason K W, Lemke, Bruno, Liu, Yang, Liu, Zhao, Lott, Melissa, Batista, Martin Lotto, Lowe, Rachel, MacGuire, Frances, Sewe, Maquins Odhiambo, Martinez-Urtaza, Jaime, Maslin, Mark, McAllister, Lucy, McGushin, Alice, McMichael, Celia, Mi, Zhifu, Milner, James, Minor, Kelton, Minx, Jan C, Mohajeri, Nahid, Moradi-Lakeh, Maziar, Morrissey, Karyn, Munzert, Simon, Murray, Kris A, Neville, Tara, Nilsson, Maria, Obradovich, Nick, O'Hare, Megan B, Oreszczyn, Tadj, Otto, Matthias, Owfi, Fereidoon, Pearman, Olivia, Rabbaniha, Mahnaz, Robinson, Elizabeth J Z, Rocklöv, Joacim, Salas, Renee N, Semenza, Jan C, Sherman, Jodi D, Shi, Liuhua, Shumake-Guillemot, Joy, Silbert, Grant, Sofiev, Mikhail, Springmann, Marco, Stowell, Jennifer, Tabatabaei, Meisam, Taylor, Jonathon, Triñanes, Joaquin, Wagner, Fabian, Wilkinson, Paul, Winning, Matthew, Yglesias-González, Marisol, Zhang, Shihui, Gong, Peng, Montgomery, Hugh, and Costello, Anthony

Published
2022
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32. Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients

Author

Torres, Rubén, Toro, Luis, Sanhueza, María Eugenia, Lorca, Eduardo, Ortiz, Mireya, Pefaur, Jacqueline, Clavero, Rene, Machuca, Eduardo, Gonzalez, Fernando, Herrera, Patricia, Mocarquer, Alfredo, Frias, Alondra, Roessler, Eric, Muñoz, Carolina, Nuñez, Miguel, Aravena, Cesar, Quintana, Enrique, Lemus, Juan, Lillo, Mario, Reynolds, Enrique, Morales, Alvaro, Pais, Edgard, Fiabane, Andrea, Parra-Lucares, Alfredo, Garrido, Cristian, Mendez-Valdes, Gabriel, Villa, Eduardo, Mansilla, Rodrigo, Sotomayor, Germana, Gonzalez, Marcela, Miranda, Cecilia, Briones, Eduardo, Gomez, Esteban, Mezzano, Sergio, Bernales, Waldo, Rocca, Ximena, Espinoza, Oscar, Zuñiga, Eric, Aragon, Henry, Badilla, Marta, Valenzuela, Marcela, Escobar, Luis, Zamora, Daniela, Flores, Ivan, Tapia, Beatriz, Borquez, Tamara, and Herrera, Patricio

Published
2022
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33. Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies

Author

Fountain, Michael D, Oleson, David S, Rech, Megan E, Segebrecht, Lara, Hunter, Jill V, McCarthy, John M, Lupo, Philip J, Holtgrewe, Manuel, Moran, Rocio, Rosenfeld, Jill A, Isidor, Bertrand, Le Caignec, Cédric, Saenz, Margarita S, Pedersen, Robert C, Morgan, Thomas M, Pfotenhauer, Jean P, Xia, Fan, Bi, Weimin, Kang, Sung-Hae L, Patel, Ankita, Krantz, Ian D, Raible, Sarah E, Smith, Wendy, Cristian, Ingrid, Torti, Erin, Juusola, Jane, Millan, Francisca, Wentzensen, Ingrid M, Person, Richard E, Küry, Sébastien, Bézieau, Stéphane, Uguen, Kévin, Férec, Claude, Munnich, Arnold, van Haelst, Mieke, Lichtenbelt, Klaske D, van Gassen, Koen, Hagelstrom, Tanner, Chawla, Aditi, Perry, Denise L, Taft, Ryan J, Jones, Marilyn, Masser-Frye, Diane, Dyment, David, Venkateswaran, Sunita, Li, Chumei, Escobar, Luis F, Horn, Denise, Spillmann, Rebecca C, Peña, Loren, Wierzba, Jolanta, Strom, Tim M, Parenti, Ilaria, Kaiser, Frank J, Ehmke, Nadja, and Schaaf, Christian P

Subjects
Biological Sciences, Genetics, Brain Disorders, Neurosciences, Behavioral and Social Science, Clinical Research, Pediatric, Congenital Structural Anomalies, Intellectual and Developmental Disabilities (IDD), Mental Health, Autism, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Autism Spectrum Disorder, Child, Child, Preschool, Chromosome Deletion, DNA-Binding Proteins, Genome, Human, Haploinsufficiency, Humans, Infant, Infant, Newborn, Intellectual Disability, Language Development Disorders, Neurodevelopmental Disorders, Nuclear Proteins, Phenotype, Problem Behavior, Proteins, Exome Sequencing, USP7, neurodevelopment, speech delay, white matter paucity, corpus callosum thinning, Clinical Sciences, Genetics & Heredity
Abstract

PurposeHaploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism spectrum disorder (ASD), seizures, and hypogonadism. Further, USP7 was identified to critically incorporate into the MAGEL2-USP7-TRIM27 (MUST), such that pathogenic variants in USP7 lead to altered endosomal F-actin polymerization and dysregulated protein recycling.MethodsWe report 16 newly identified individuals with heterozygous USP7 variants, identified by genome or exome sequencing or by chromosome microarray analysis. Clinical features were evaluated by review of medical records. Additional clinical information was obtained on the seven previously reported individuals to fully elucidate the phenotypic expression associated with USP7 haploinsufficiency.ResultsThe clinical manifestations of these 23 individuals suggest a syndrome characterized by DD/ID, hypotonia, eye anomalies,feeding difficulties, GERD, behavioral anomalies, and ASD, and more specific phenotypes of speech delays including a nonverbal phenotype and abnormal brain magnetic resonance image findings including white matter changes based on neuroradiologic examination.ConclusionThe consistency of clinical features among all individuals presented regardless of de novo USP7 variant type supports haploinsufficiency as a mechanism for pathogenesis and refines the clinical impact faced by affected individuals and caregivers.

Published
2019

34. Summary results of the 2014-2015 DARPA Chikungunya challenge

Author

Del Valle, Sara Y, McMahon, Benjamin H, Asher, Jason, Hatchett, Richard, Lega, Joceline C, Brown, Heidi E, Leany, Mark E, Pantazis, Yannis, Roberts, David J, Moore, Sean, Peterson, A Townsend, Escobar, Luis E, Qiao, Huijie, Hengartner, Nicholas W, and Mukundan, Harshini

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Rare Diseases, Vector-Borne Diseases, Prevention, Biodefense, Infectious Diseases, Vaccine Related, Infection, Good Health and Well Being, Chikungunya Fever, Demography, Dengue, Disease Outbreaks, Forecasting, Humans, Infection Control, Organizational Innovation, Research Design, Security Measures, United States, United States Department of Defense, Zika Virus Infection, Chikungunya, Mechanistic models, Morphological models, Microbiology, Medical Microbiology, Clinical sciences, Medical microbiology, Public health
Abstract

BackgroundEmerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are critical to minimizing subsequent mortality, morbidity, and economic loss. The recent introduction of chikungunya and Zika virus to the Americas underscores the need for better methods for disease surveillance and forecasting.MethodsTo explore the suitability of current approaches to forecasting emerging diseases, the Defense Advanced Research Projects Agency (DARPA) launched the 2014-2015 DARPA Chikungunya Challenge to forecast the number of cases and spread of chikungunya disease in the Americas. Challenge participants (n=38 during final evaluation) provided predictions of chikungunya epidemics across the Americas for a six-month period, from September 1, 2014 to February 16, 2015, to be evaluated by comparison with incidence data reported to the Pan American Health Organization (PAHO). This manuscript presents an overview of the challenge and a summary of the approaches used by the winners.ResultsParticipant submissions were evaluated by a team of non-competing government subject matter experts based on numerical accuracy and methodology. Although this manuscript does not include in-depth analyses of the results, cursory analyses suggest that simpler models appear to outperform more complex approaches that included, for example, demographic information and transportation dynamics, due to the reporting biases, which can be implicitly captured in statistical models. Mosquito-dynamics, population specific information, and dengue-specific information correlated best with prediction accuracy.ConclusionWe conclude that with careful consideration and understanding of the relative advantages and disadvantages of particular methods, implementation of an effective prediction system is feasible. However, there is a need to improve the quality of the data in order to more accurately predict the course of epidemics.

Published
2018

35. Surgeons' Recommendations for Neurodiagnostic Testing With High Pretest Probability of Idiopathic Median Neuropathy at the Carpal Tunnel

Author

Adams, Julie E., Adolfsson, Lars E., Apard, Thomas, Ashmead, Duffield, Bainbridge, L. Christopher, Bamberger, Hugh Brent, Baxamusa, Taizoon, Buendia, Luis A., Butters, Kenneth, Cagnone, Juan Carlos, Calcagni, Maurizio, Carpeggiani, Guilherme, Casstevens, Chritopher E., Chivers, Kevin, de Bedout, Ramon, Dwyer, C. Liam, Erickson, John M., Erol, Kent, Evans, Peter J., Falcon, Daniel, Farr, Sebastian, Fernandes, Carlos Henrique, Fischer, Thomas J., Gilbert, Richard S., Gire, Jacob D., Giuffrida, Angela Ylenia, Gosens, Taco, Grafe, Michael W., Gray, Robert R.L., Greenberg, Jeffrey A., Guitton, Thierry G., Hammert, Warren C., Hearon, Bernard F., Henry, Steven L., Hofmeister, Eric P., Huang, Jerry I., Ibrahim, Eric F., Jebson, Peter, Kakar, Sanjeev, Kaplan, F. Thomas D., Kennedy, Stephen A., Ko, Jason H., Kronlage, Steven, Lee, Kenneth E., Marcus, Alexander M., McAuliffe, John A., Mitchell, Stephen, Moreno-Serrano, Constanza Lucia, Nancollas, Michael P., Napoli, David C., Nappi, James F., Naquira Escobar, Luis Felipe, Nolan, Betsy M., Ortiz, Jose A., II, Paladini, Paolo, Palmer, Bradley A., Palmer, Michael Jason, Parnes, Nata, Patiño, Juan Martin, Patterson, D. Paul, Pianka, George, Pirela Cruz, Miguel A., Platz, Andreas, Polatsch, Daniel, Richardson, Mark, Ruch, David, Rumball, Kevin M., Samora, Julie B., Satteson, Ellen S., Schumer, Evan D., Shafritz, Adam B., Siff, Todd, Sitaram, Prasad, Souer, J. Sebastiaan, Spaans, Anne, Sutker, Benjamin, Talsania, Jay, Tavakolian, Jason D., Terrono, Andrew L., van der Pluijm, Marco, van Riet, Roger, Vochteloo, Ali J., Walbeehm, Ryan P., Walsh, Christopher J., Weiss, Lawrence, Willems, W. Jaap, Wills, Brian P.D., Wint, Jeffrey, Wood, Megan M., Zalavras, Charalampos, Zeltser, David W., Crijns, Tom Joris, Mucharraz, Carlos, Paravasthuramesh, Abinaya, Teunis, Teun, Ring, David, and Fatehi, Amirreza

Published
2022
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36. Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19

Author

Buyukozkan, Mustafa, Alvarez-Mulett, Sergio, Racanelli, Alexandra C., Schmidt, Frank, Batra, Richa, Hoffman, Katherine L., Sarwath, Hina, Engelke, Rudolf, Gomez-Escobar, Luis, Simmons, Will, Benedetti, Elisa, Chetnik, Kelsey, Zhang, Guoan, Schenck, Edward, Suhre, Karsten, Choi, Justin J., Zhao, Zhen, Racine-Brzostek, Sabrina, Yang, He S., Choi, Mary E., Choi, Augustine M.K., Cho, Soo Jung, and Krumsiek, Jan

Published
2022
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37. Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Price, David R., Benedetti, Elisa, Hoffman, Katherine L., Gomez-Escobar, Luis, Alvarez-Mulett, Sergio, Capili, Allyson, Sarwath, Hina, Parkhurst, Christopher N., Lafond, Elyse, Weidman, Karissa, Ravishankar, Arjun, Cheong, Jin Gyu, Batra, Richa, Büyüközkan, Mustafa, Chetnik, Kelsey, Easthausen, Imaani, Schenck, Edward J., Racanelli, Alexandra C., Outtz Reed, Hasina, Laurence, Jeffrey, Josefowicz, Steven Z., Lief, Lindsay, Choi, Mary E., Schmidt, Frank, Borczuk, Alain C., Choi, Augustine M.K., Krumsiek, Jan, and Rafii, Shahin

Published
2022
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38. Imposter Syndrome Among Surgeons Is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving

Author

Lin, Eugenia, Crijns, Tom J., Ring, David, Jayakumar, Prakash, Cruz, Miguel Pirela, Kraan, Gerald A., Muhl, Philipp, Gilbert, Richard S., Siff, Todd, Spaans, Anne, Shafritz, Adam, Adams, Julie, Vochteloo, Anne J.H., Platz, Andreas, Terrono, Andrew L., Bafus, Todd, Bamberger, H. Brent, Sutker, Ben, Hearon, Bernard F., Braman, Jonathan, Calfee, Ryan P., Ekholm, Carl, Fernandes, Carlos H., Metzger, Charles, Bainbridge, Chris, Moreno-Serrano, Constanza L., Ashmead, Duffield, IV, Drosdowech, Darren, McKee, Desirae M., Falcon, Daniel, Polatsch, Dan, Patterson, David P., Romero Barreto, Camilo Jose, Shafi, Mohamed, Patiño, Juan M., van Riet, Roger, Raven, Eric, Satteson, Ellen, Walbeehm, Erik T., Schumer, Evan D., Zaidenberg, Ezequiel E., Suarez, Fabio, OʼBrien, Fred, Verstreken, Frederik, Pianka, George, Bayne, Grant, Fierro, Guido, Guitton, Thierry G., Nancollas, Michael, Greenberg, Jeffrey A., Watchmaker, Greg P., Lane, Lewis B., Hofmeister, Eric P., Kazanjian, Jack E., Brubacher, Jacob W., Gire, Jacob, Tavakolian, Jason D., Nappi, James F., Erickson, John M., Taras, John, Samora, Julie Balch, Kakar, Sanjeev, Butters, Ken, Lee, Kendrick E., Rumball, Kevin, Weiss, Lawrence, Adolfsson, Lars, Dwyer, C. Liam, Naquira Escobar, Luis F., van der Pluijm, Marco, Richard, Marc J., Calcagni, Maurizio, McAuliffe, John A., Ruiz-Suarez, Michell, Palmer, Michael J., Grafe, Michael W., Akabudike, Ngozi M., Hoekzema, Nathan A., Richardson, Martin, Ortiz, Jose A., Jr, Johnson, Jeff W., Benhaim, Prosper, Blazar, Philip, Jebson, Peter, Owens, Patrick W., Walbeehm, Ralf, de Bedout, Ramon, Shatford, Russell, Rowinski, Sergio, Wallensten, Richard, Rodner, Craig, Sabesan, Vani J., Kennedy, Stephen A., Nolan, Betsy M., Kronlage, Steve, Souer, Sebastiaan, Henry, Steven L., Gosens, Taco, Baxamusa, Taizoon, Kaplan, F. Thomas D., Apard, Thomas, Willems, W. Jaap, Hammert, Warren C., and Waseem, Mohammad

Published
2023
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40. Tracking the impacts of climate change on human health via indicators: lessons from the Lancet Countdown

Author

Di Napoli, Claudia, McGushin, Alice, Romanello, Marina, Ayeb-Karlsson, Sonja, Cai, Wenjia, Chambers, Jonathan, Dasgupta, Shouro, Escobar, Luis E., Kelman, Ilan, Kjellstrom, Tord, Kniveton, Dominic, Liu, Yang, Liu, Zhao, Lowe, Rachel, Martinez-Urtaza, Jaime, McMichael, Celia, Moradi-Lakeh, Maziar, Murray, Kris A., Rabbaniha, Mahnaz, Semenza, Jan C., Shi, Liuhua, Tabatabaei, Meisam, Trinanes, Joaquin A., Vu, Bryan N., Brimicombe, Chloe, and Robinson, Elizabeth J.

Published
2022
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41. A database of common vampire bat reports

Author

Van de Vuurst, Paige, Díaz, M. Mónica, Rodríguez-San Pedro, Annia, Allendes, Juan Luis, Brown, Natalie, Gutiérrez, Juan David, Zarza, Heliot, de Oliveira, Stefan V., Cárdenas-Canales, Elsa, Barquez, Rubén M., and Escobar, Luis E.

Published
2022
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42. Flexible Manufacturing Systems Optimization with Meta-heuristic Algorithm Using Open Source Software

Author

Izquierdo, Fabian, Garcia, Edwin, Cortez, Byron, Escobar, Luis, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Botto Tobar, Miguel, editor, Cruz, Henry, editor, and Díaz Cadena, Angela, editor

Published
2021
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43. YaniWawa: An Innovative Tool for Teaching Using Programmable Models over Augmented Reality Sandbox

Author

Cárdenas-Delgado, Sonia, Padilla Almeida, Oswaldo, Loachamín-Valencia, Mauricio, Rivera, Henry, Escobar, Luis, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Botto-Tobar, Miguel, editor, Zamora, Willian, editor, Larrea Plúa, Johnny, editor, Bazurto Roldan, José, editor, and Santamaría Philco, Alex, editor

Published
2021
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44. Kidney Recovery and Death in Critically Ill Patients With COVID-19–Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study

Author

Gupta, Hsu, Faugno, Goyal, Raichoudhury, Tariq, Meyer, Sharma, Leaf, Kshirsagar, Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Bauer, Kenneth A., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, WilliamsSamantha K. Brenner, Aquino, Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Tehranian, Shahrzad, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns. Ryan Mocerino, Tanya S., Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Thakkar, Jyotsana, Kumar, Neelja, Ross, Michael J., Chang, Michael, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner M.B., Avasare, Rupali S., Zonies, David, Al-Samkari, Hanny, Leaf, Rebecca Karp, Rosovsky, Rachel, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Karp, George, Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Sharshir, Moh’d A., Rusnak, Vadym V., Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, RheeKa, Harin, thleen D. Liu, Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Dy, Rajany, Iardino, Alfredo, Au, Elizabeth H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Fornoni, Alessia, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Chugh, Savneek, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Hsu, Caroline M., Gupta, Shruti, Tighiouart, Hocine, Goyal, Nitender, Faugno, Anthony J., Tariq, Asma, Raichoudhury, Ritesh, Sharma, Jill H., Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Leaf, David E., and Weiner, Daniel E.

Published
2022
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45. Human cat borne rabies as the new epidemiology of the disease in the Andes mountains.

Author

Meriño‐Olivella, Samir, del Pilar Sánchez‐Bonilla, María, Escobar, Luis E., and Correa‐Valencia, Nathalia M.

Subjects
RABIES, CATS, RABIES vaccines, FELIDAE, EPIDEMIOLOGY, RABIES virus, VIRUS diseases, FLEA control
Abstract

Background: Rabies virus (RABV) is the etiologic agent of rabies, a fatal brain disease in mammals. Rabies circulation has historically involved the dog has the main source of human rabies worldwide. Nevertheless, in Colombia, cats (Felis catus) have become a relevant species in the epidemiology of rabies. Aims: To characterize rabies cases in humans in Colombia in the last three decades in the context of the epidemiology of the aggressor animal. Materials and Methods: We conducted a retrospective longitudinal epidemiological study of human rabies caused by cats' aggression, collecting primary and secondary information. Variables considered included the demography of the patient, symptoms, information about the aggressor animal as the source of infection and the viral variant identified. Results: We found that the distribution of rabies incidence over the years has been constant in Colombia. Nevertheless, between 2003 and 2012 a peak of cases occurred in rural Colombia where cats were the most frequent aggressor animal reported. Most cats involved in aggression were unvaccinated against rabies. Cat's clinical signs at the time of the report of the human cases included hypersalivation and changes in behaviour. Human patients were mostly children and female and the exposure primarily corresponded to bite and puncture lacerations in hands. The RABV lineage detected in most cases corresponded to variant 3, linked to the common vampire bat (Desmodus rotundus). The geographical presentation of cat borne RABV in humans occurred along the Andes mountains, epidemiologically known as the rabies red Andean corridor. Discussion: By finding cats as the primary source of rabies spillover transmission in Colombia, this report highlights the importance of revising national rabies control and prevention protocol in countries in the Andes region. Conclusion: Our results demonstrate that rabies vaccination for outdoor cats needs to prioritize to reduce the number of rabies‐related human deaths. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Modeling the risk of aquatic species invasion spread through boater movements and river connections.

Author

Kinsley, Amy C., Kao, Szu‐Yu Zoe, Enns, Eva A., Escobar, Luis E., Qiao, Huijie, Snellgrove, Nicholas, Muellner, Ulirich, Muellner, Petra, Muthukrishnan, Ranjan, Craft, Meggan E., Larkin, Daniel J., and Phelps, Nicholas B. D.

Subjects
ZEBRA mussel, INTRODUCED species, SPECIES, BIOLOGICAL invasions, BODIES of water, ECOSYSTEMS, BALLAST water
Abstract

Copyright of Conservation Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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50. Imposter Syndrome Among Surgeons Is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving

Author

Lin, Eugenia, Crijns, Tom J., Ring, David, Jayakumar, Prakash, Cruz, Miguel Pirela, Kraan, Gerald A., Muhl, Philipp, Gilbert, Richard S., Siff, Todd, Spaans, Anne, Shafritz, Adam, Adams, Julie, Vochteloo, Anne J.H., Platz, Andreas, Terrono, Andrew L., Bafus, Todd, Bamberger, H. Brent, Sutker, Ben, Hearon, Bernard F., Braman, Jonathan, Calfee, Ryan P., Ekholm, Carl, Fernandes, Carlos H., Metzger, Charles, Bainbridge, Chris, Moreno-Serrano, Constanza L., Ashmead, Duffield, IV, Drosdowech, Darren, McKee, Desirae M., Falcon, Daniel, Polatsch, Dan, Patterson, David P., Romero Barreto, Camilo Jose, Shafi, Mohamed, Patiño, Juan M., van Riet, Roger, Raven, Eric, Satteson, Ellen, Walbeehm, Erik T., Schumer, Evan D., Zaidenberg, Ezequiel E., Suarez, Fabio, OʼBrien, Fred, Verstreken, Frederik, Pianka, George, Bayne, Grant, Fierro, Guido, Guitton, Thierry G., Nancollas, Michael, Greenberg, Jeffrey A., Watchmaker, Greg P., Lane, Lewis B., Hofmeister, Eric P., Kazanjian, Jack E., Brubacher, Jacob W., Gire, Jacob, Tavakolian, Jason D., Nappi, James F., Erickson, John M., Taras, John, Samora, Julie Balch, Kakar, Sanjeev, Butters, Ken, Lee, Kendrick E., Rumball, Kevin, Weiss, Lawrence, Adolfsson, Lars, Dwyer, C. Liam, Naquira Escobar, Luis F., van der Pluijm, Marco, Richard, Marc J., Calcagni, Maurizio, McAuliffe, John A., Ruiz-Suarez, Michell, Palmer, Michael J., Grafe, Michael W., Akabudike, Ngozi M., Hoekzema, Nathan A., Richardson, Martin, Ortiz, Jose A., Jr, Johnson, Jeff W., Benhaim, Prosper, Blazar, Philip, Jebson, Peter, Owens, Patrick W., Walbeehm, Ralf, de Bedout, Ramon, Shatford, Russell, Rowinski, Sergio, Wallensten, Richard, Rodner, Craig, Sabesan, Vani J., Kennedy, Stephen A., Nolan, Betsy M., Kronlage, Steve, Souer, Sebastiaan, Henry, Steven L., Gosens, Taco, Baxamusa, Taizoon, Kaplan, F. Thomas D., Apard, Thomas, Willems, W. Jaap, Hammert, Warren C., and Waseem, Mohammad

Published
2022
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