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7. Can we use the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume values for the diagnosis of anterior uveitis in patients with Behcet’s disease?

Author

Atıl Avcı, Deniz Avci, Kemal Özyurt, Fatma Erden, Ali Cetinkaya, Ertas Ragip, and Mustafa Atasoy

Subjects
medicine.medical_specialty, Therapeutics and Clinical Risk Management, Lymphocyte, PLR, Behcet's disease, 030204 cardiovascular system & hematology, Gastroenterology, MPV, NLR, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Pharmacology (medical), In patient, Platelet, General Pharmacology, Toxicology and Pharmaceutics, Neutrophil to lymphocyte ratio, Mean platelet volume, Original Research, Chemical Health and Safety, business.industry, fungi, General Medicine, medicine.disease, Surgery, body regions, medicine.anatomical_structure, uveitis, 030221 ophthalmology & optometry, Anterior uveitis, business, Safety Research, Behcet’s disease, Uveitis
Abstract

Atil Avci,1 Deniz Avci,2 Fatma Erden,3 Ertas Ragip,1 Ali Cetinkaya,2 Kemal Ozyurt,1 Mustafa Atasoy1 1Department of Dermatology and Venereology, Kayseri Training and Research Hospital, Kayseri, Turkey; 2Internal Medicine Department, Kayseri Training and Research Hospital, Kayseri, Turkey; 3Department of Dermatology and Venereology, Cubuk State Hospital, Ankara, Turkey Introduction: The purpose of this study was to compare the value of hematological parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), as indicators of anterior uveal segment involvement in patients with Behcet’s disease (BD). Patients and methods: Hospital-based records of a total of 912 patients with BD from the dermatology clinic and healthy volunteers from the checkup clinic were assessed retrospectively. After applying the exclusion criteria of the study, 71 of the BD patients with anterior uveitis, 69 of the BD patients without ophthalmological pathology and 151 healthy volunteers were included in the study. MPV, PLR, and NLR values of patients and healthy volunteers were compared. Results: All MPV, PLR, and NLR values of patients who had anterior uveitis were significantly higher than those of other patients and healthy volunteers. Statistically, considering area under curves (ratio): NLR was 0.725 (0.653–0.797), P

Published
2017
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8. Definition, aims, and implementation of GA(2)LEN/HAEi Angioedema Centers of Reference and Excellence

Author

Maurer, Marcus Werner, Aberer Agondi, Rosana Al-Ahmad, Mona and Al-Nesf, Maryam Ali Ansotegui, Ignacio Arnaout, Rand and Arruda, Luisa Karla Asero, Riccardo Aygoeren-Puersue, Emel and Banerji, Aleena Bauer, Andrea Ben-Shoshan, Moshe Berardi, Alejandro Bernstein, Jonathan A. Betschel, Stephen and Bindslev-Jensen, Carsten Bizjak, Mojca Boccon-Gibod, Isabelle and Bork, Konrad Bouillet, Laurence Boysen, Henrik Balle and Brodszki, Nicholas Broesby-Olsen, Sigurd Busse, Paula and Buttgereit, Thomas Bygum, Anette Caballero, Teresa Campos, Regis A. Cancian, Mauro Cherrez-Ojeda, Ivan Cohn, Danny M. and Costa, Celia Craig, Timothy Criado, Paulo Ricardo and Criado, Roberta F. Csuka, Dorottya Dissemond, Joachim and Du-Thanh, Aurelie Ensina, Luis Felipe Ertas, Ragip Fabiani, Jose E. Fantini, Claudio Farkas, Henriette Ferrucci, Silvia Mariel Figueras-Nart, Ignasi Fili, Natalia L. Fomina, Daria and Fukunaga, Atsushi Gelincik, Asli Gimenez-Arnau, Ana and Godse, Kiran Gompels, Mark Goncalo, Margarida Gotua, Maia and Gower, Richard Grumach, Anete S. Guidos-Fogelbach, Guillermo and Hide, Michihiro Ilina, Natalia Inomata, Naoko Jakob, Thilo Josviack, Dario O. Kang, Hye-Ryun Kaplan, Allen and Kasperska-Zajac, Alicja Katelaris, Constance Kessel, Aharon and Kleinheinz, Andreas Kocaturk, Emek Kosnik, Mitja Krasowska, Dorota Kulthanan, Kanokvalai Kumaran, M. Sendhil Larco Sousa, Jose Ignacio Longhurst, Hilary J. Lumry, William and MacGinnitie, Andrew Magerl, Markus Makris, Michael P. and Malbran, Alejandro Marsland, Alexander Martinez-Saguer, Inmaculada Medina, Iris V. Meshkova, Raisa Metz, Martin and Nasr, Iman Nicolay, Jan Nishigori, Chikako Ohsawa, Isao and Ozyurt, Kemal Papadopoulos, Nikolaos G. Parisi, Claudio A. S. and Peter, Jonathan Grant Pfuetzner, Wolfgang Popov, Todor and Prior, Nieves Ramon, German D. Reich, Adam Reshef, Avner and Riedl, Marc A. Ritchie, Bruce Rockmann-Helmbach, Heike and Rudenko, Michael Salman, Andac Sanchez-Borges, Mario and Schmid-Grendelmeier, Peter Serpa, Faradiba S. Serra-Baldrich, Esther Sheikh, Farrukh R. Smith, William Soria, Angele and Staubach, Petra Steiner, Urs C. Stobiecki, Marcin Sussman, Gordon Tagka, Anna Thomsen, Simon Francis Treudler, Regina and Valle, Solange van Doorn, Martijn Varga, Lilian Vazquez, Daniel O. Wagner, Nicola Wang, Liangchun Weber-Chrysochoou, Christina Ye, Young-Min Zalewska-Janowska, Anna Zanichelli, Andrea Zhao, Zuotao Zhi, Yuxiang Zuberbier, Torsten and Zwiener, Ricardo D. Castaldo, Anthony

Published
2020

10. Netherton syndrome previously misdiagnosed as hyper IgE syndrome caused by a probable mutation in SPINK5 C

Author

Ozyurt, Kemal, Atasoy, Mustafa, Ertas, Ragip, Ulas, Yilmaz, Akkus, Muhammed Resat, Kiraz, Ashhan, Hennies, Hans Christian, Ozyurt, Kemal, Atasoy, Mustafa, Ertas, Ragip, Ulas, Yilmaz, Akkus, Muhammed Resat, Kiraz, Ashhan, and Hennies, Hans Christian

Abstract

Netherton syndrome (NS, MIM256500) is an autosomal recessive disorder that includes ichthyosis linearis circumflexa and a predisposition to allergies, asthma, and eczema, with hypereosinophilia, trichorrhexis invaginata, and elevated serum IgE levels. The genetic bases of Netherton syndrome are mutations in the gene SPINK5, and the Lymphoepitheial Kazal type related inhibitor, a serine protease inhibitor, is encoded by SPINK. Here a case is presented which showed a probable splice site mutation in SPINK5, which was previously unknown in databases and the literature, to point out the misdiagnosis of Hyper IgE Syndrome in the early presentation of the phenotype. This case highlights that a genetic test can be critical for identifying NS. The finding of underlying mutations contributes to the understanding of Netherton syndrome and is instrumental in indicating a specific therapy. Notably, treatment with acitretin has significantly improved both the ichthyosis linearis circumflexa and eczema in our patient.

Published
2019

14. Androgenetic alopecia as an indicator of metabolic syndrome and cardiovascular risk.

Author

Ertas, Ragip, Orscelik, Ozcan, Kartal, Demet, Dogan, Ali, Ertas, Sule Ketenci, Aydogdu, Ebru Guler, Ascioglu, Ozcan, and Borlu, Murat

Subjects
*METABOLIC syndrome diagnosis, *BALDNESS, *CARDIOVASCULAR diseases risk factors, *ARTERIAL diseases, *INSULIN resistance, *CAROTID intima-media thickness, *PHYSIOLOGY, *DISEASE risk factors, RISK factors
Abstract

Numerous studies have investigated a probable association between androgenetic alopecia (AGA) and cardiovascular disease (CVD) by researching limited and dispersed parameters. We aimed to evaluate both traditional and non-traditional cardiovascular risk factors in male patients with early-onset AGA. This case–control study included 68 participants: 51 male patients with early-onset AGA and 17 healthy male controls. Patients with AGA were classified into three groups according to the Hamilton–Norwood scale and the presence of vertex hair loss. Traditional and non-traditional cardiovascular risk factors were examined in all study subjects. Metabolic syndrome was diagnosed in 25 patients with AGA and in two control subjects (p < 0.05). The carotid intima–media thickness values were found to be significantly higher in patients with vertex pattern AGA than in patients without vertex baldness and controls (p < 0.05). The pulse-wave velocity values were also found to be significantly higher in patients (p < 0.001). A limitation of this study was the small study population. In conclusion, vertex pattern AGA appears to be a marker for early atherosclerosis. This finding supports the hypothesis that early-onset AGA alone could be an independent risk factor for CVD and metabolic syndrome. [ABSTRACT FROM PUBLISHER]

Published
2016
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15. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Author

Kocatürk, Emek, Salman, Andaç, Cherrez-Ojeda, Ivan, Criado, Paulo Ricardo, Peter, Jonny, Comert-Ozer, Elif, Abuzakouk, Mohamed, Câmara Agondi, Rosana, Al-Ahmad, Mona, Altrichter, Sabine, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Bauer, Andrea, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bizjak, Mojca, Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Busse, Paula, Campos, Regis A., Carne, Emily, Conlon, Niall, Criado, Roberta Fachini Jardim, De Souza Lima, Eduardo Magalhães, Demir, Semra, Dissemond, Joachim, Doğan Günaydın, Sibel, Dorofeeva, Irina, Ensina, Luis Felipe, Ertaş, Ragip, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fomina, Daria, Franken, Sylvie M., Fukunaga, Atsushi, Giménez Arnau, Ana M, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Guillet, Carole, Inomata, Naoko, Jakob, Thilo, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Košnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M.Sendhil, Lang, Claudia, Larco-Sousa, José Ignacio, Lazaridou, Elisavet, Leslie, Tabi Anika, Lippert, Undine, Calderón llosa, Oscar, Makris, Michael, Marsland, Alexander, Medina, Iris V., Meshkova, Raisa, Bastos Palitot, Esther, Parisi, Claudio A.S., Pickert, Julia, Ramon, Germán D., Rodríguez-Gonzalez, Mónica, Rosario, Nelson, Rudenko, Michael, Rutkowski, Krzysztof, Sánchez Caraballo, Jorge Mario, Schliemann, Sibylle, Sekerel, Bulent Enis, Serpa, Faradiba S., Serra-Baldrich, E, Song, Zhiqiang, Soria, Angèle, Staevska, Maria, Staubach, Petra, Tagka, Anna, Takahagi, Shunsuke, Thomsen, Simon Francis, Treudler, Regina, Vadasz, Zahava, Rodrigues Valle, Solange Oliveira, Van Doorn, Martijn B.A., Vestergaard, Christian, Wagner, Nicola, Wang, Dahu, Wang, Liangchun, Wedi, Bettina, Xepapadaki, Paraskevi, Yücel, Esra, Zalewska-Janowska, Anna, Zhao, Zuotao, Zuberbier, Torsten, Maurer, Marcus, Universitat Autònoma de Barcelona, Dermatology, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Salman, A., Cherrez-Ojeda, I., Criado, P. R., Peter, J., Comert-Ozer, E., Abuzakouk, M., Agondi, R. C., Al-Ahmad, M., Altrichter, S., Arnaout, R., Arruda, L. K., Asero, R., Bauer, A., Ben-Shoshan, M., Bernstein, J. A., Bizjak, M., Boccon-Gibod, I., Bonnekoh, H., Bouillet, L., Brzoza, Z., Busse, P., Campos, R. A., Carne, E., Conlon, N., Criado, R. F., Lima, E. M. D., Demir, S., Dissemond, J., Gunaydin, S. D., Dorofeeva, I., Ensina, L. F., Ertas, R., Ferrucci, S. M., Figueras-Nart, I., Fomina, D., Franken, S. M., Fukunaga, A., Gimenez-Arnau, A. M., Godse, K., Goncalo, M., Gotua, M., Grattan, C., Guillet, C., Inomata, N., Jakob, T., Karakaya, G., Kasperska-Zajac, A., Katelaris, C. H., Kosnik, M., Krasowska, D., Kulthanan, K., Kumaran, M. S., Lang, C., Larco-Sousa, J. I., Lazaridou, E., Leslie, T. A., Lippert, U., Llosa, O. C., Makris, M., Marsland, A., Medina, I. V., Meshkova, R., Palitot, E. B., Parisi, C. A. S., Pickert, J., Ramon, G. D., Rodriguez-Gonzalez, M., Rosario, N., Rudenko, M., Rutkowski, K., Sanchez, J., Schliemann, S., Sekerel, B. E., Serpa, F. S., Serra-Baldrich, E., Song, Z. Q., Soria, A., Staevska, M., Staubach, P., Tagka, A., Takahagi, S., Thomsen, S. F., Treudler, R., Vadasz, Z., Valle, S. O. R., Van Doorn, M. B. A., Vestergaard, C., Wagner, N., Wang, D. H., Wang, L. C., Wedi, B., Xepapadaki, P., Yücel, E., Zalewska-Janowska, A., Zhao, Z. T., Zuberbier, T., Maurer, M., School of Medicine, AII - Infectious diseases, Kocaturk, Emek, Salman, Andac, Cherrez-Ojeda, Ivan, Criado, Paulo Ricardo, Peter, Jonny, Comert-Ozer, Elif, Abuzakouk, Mohamed, Agondi, Rosana Camara, Al-Ahmad, Mona, Altrichter, Sabine, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Bauer, Andrea, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bizjak, Mojca, Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Busse, Paula, Campos, Regis A., Carne, Emily, Conlon, Niall, Criado, Roberta F., de Souza Lima, Eduardo M., Demir, Semra, Dissemond, Joachim, Gunaydin, Sibel Dogan, Dorofeeva, Irina, Ensina, Luis Felipe, Ertas, Ragip, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fomina, Daria, Franken, Sylvie M., Fukunaga, Atsushi, Gimenez-Arnau, Ana M., Godse, Kiran, Goncalo, Margarida, Gotua, Maia, Grattan, Clive, Guillet, Carole, Inomata, Naoko, Jakob, Thilo, Karakaya, Gul, Kasperska-Zajac, Alicja, Katelaris, Constance H., Kosnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Lang, Claudia, Ignacio Larco-Sousa, Jose, Lazaridou, Elisavet, Leslie, Tabi Anika, Lippert, Undine, Llosa, Oscar Calderon, Makris, Michael, Marsland, Alexander, Medina, Iris, V, Meshkova, Raisa, Palitot, Esther Bastos, Parisi, Claudio A. S., Pickert, Julia, Ramon, German D., Rodriguez-Gonzalez, Monica, Rosario, Nelson, Rudenko, Michael, Rutkowski, Krzysztof, Sanchez, Jorge, Schliemann, Sibylle, Sekerel, Bulent Enis, Serpa, Faradiba S., Serra-Baldrich, Esther, Song, Zhiqiang, Soria, Angele, Staevska, Maria, Staubach, Petra, Tagka, Anna, Takahagi, Shunsuke, Thomsen, Simon Francis, Treudler, Regina, Vadasz, Zahava, Rodrigues Valle, Solange Oliveira, Van Doorn, Martijn B. A., Vestergaard, Christian, Wagner, Nicola, Wang, Dahu, Wang, Liangchun, Wedi, Bettina, Xepapadaki, Paraskevi, Yucel, Esra, Zalewska-Janowska, Anna, Zhao, Zuotao, Zuberbier, Torsten, and Maurer, Marcus

Subjects
Male, 0301 basic medicine, STRESS, Exacerbation, UCARE, pandemije, Medizin, Omalizumab, SERUM, chronic urticaria, 0302 clinical medicine, Pandemic, Health care, Immunology and Allergy, Chronic Urticaria, treatment, Chronic urticaria, COVID-19, Cyclosporine, SARS-CoV-2, Treatment, zdravljenje, ASSOCIATION, Middle Aged, cyclosporine, omalizumab, pandemic, kronična urtikarija, INFECTIONS, GA(2)LEN, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), Immunology, udc:616-097, pandemics, ciklosporin, Young Adult, 03 medical and health sciences, Patient referral, medicine, Humans, In patient, Patient Reported Outcome Measures, Aged, Internet, business.industry, DEFINITION, Medicine, Allergy, Cross-Sectional Studies, 030104 developmental biology, 030228 respiratory system, Emergency medicine, business
Abstract

Introduction: the COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. Aim: to understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. Materials and methods: our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. Results: the COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three patients, with higher rates in patients with severe COVID-19. Conclusions: the COVID-19 pandemic brings major changes and challenges for CU patients and their physicians. The long-term consequences of these changes, especially the increased use of remote consultations, require careful evaluation., Novartis; Sanofi; Menarini Universidad Espiritu Santo; Takeda; Allakos; AstraZeneca; CSL Behring; Genentech; Pharming; GSK; Shire/Takada; BioCryst; ResTORbio; Pearl Therapeutics, CVS Health; Law offices of Levin; Riback; Adelman; Flangel; Vedder Price; Fresenius; Taiho; Kyowa Kirin; Tanabe; Korin; Uriach Pharma; Instituto Carlos III FEDER; Menarini; Amgen; Thermo Fisher; Avene; ALK‐Abello; Bencard/Allergy Therapeutics; Celgene; Allergopharma; Faes Farma; AbbVie; Janssen; Leo Pharma; Lilly; Roche; Genesis; Menlo Therapeutics; UCB; Pfizer; Almirall; Galderma; Allergika; Beiersdorf; Biocryst; Biogen Idec; BMS; Boehringer‐Ingelheim; Eli‐Lilly; Galderma; Hexal; Klosterfrau; LEO‐Pharma; LETI‐Pharma; L´Oreal; Medice; Octapharma; Pflüger; Pharming; Regeneron; Shire; ALK‐Abello; Fraunhofer‐IZI Leipzig; Hautnetz Leipzig/Westsachsen; MSD; HAL‐Allergy; Bencard; Nestle; Nutricia; Bayer Health Care; FAES; Henkel; Allakos; Argenx; Genentech Menarini; Moxie; Aralez; Celldex

Published
2021
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16. Eating increases disease activity in pediatric patients with symptomatic dermographism.

Author

Eke Gungor H, Turk M, Yucel MB, Koca SB, Yuce Atamulu K, Maurer M, and Ertas R

Subjects
Humans, Child, Female, Male, Adolescent, Skin Tests, Urticaria diagnosis, Urticaria etiology, Chronic Urticaria diagnosis, Severity of Illness Index, Eating
Abstract

Background: Symptomatic dermographism (SD) is the most common form of chronic inducible urticaria. SD disease activity increases with food intake in adult patients. Whether this is also so in children with SD is currently unknown. Objective: To assess children with SD for their disease activity by standardized provocation testing before and after eating. Methods: We subjected 44 children with SD (29 girls; median [interquartile range] age 12.5 years [8.3-15 years]), before and after eating, to standardized skin provocation testing with a dermographometer. Dermographometer scores were calculated based on responses evaluated at 1-minute intervals for 10 minutes and recorded as negative (-) or positive (+ to ++++). Clinical characteristics and urticaria control test scores were documented. Results: Dermographometer scores before eating were 2.3 of 4 on average and inversely correlated with urticaria control test scores. Dermographometer scores were higher after eating than before eating. Of 44 children with SD, 35 had increased dermographometer scores after eating and 9 patients had a postprandial increase of ≥1 point. Eating-induced increases in dermographometer scores were linked to earlier whealing in 17 of 35 patients, and differences in preprandial versus postprandial dermographometer responses were more pronounced at earlier than later time points after testing. Conclusion: Disease activity, as assessed by provocation testing, is increased in most pediatric patients with SD after eating. Future studies should explore the prevalence of food-exacerbated SD in larger pediatric SD populations. Most pediatric patients with symptomatic dermographism have higher disease activity, assessed by provocation testing, after eating as compared to before eating. Standardized provocation testing and trigger threshold assessments in children with symptomatic dermographism should be performed before and after eating. Knowledge of food-exacerbated disease may help patients with the management of their symptomatic dermographism.

Published
2024
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17. Does omalizumab treatment affect serum dehydroepiandrosterone sulphate levels in chronic idiopathic urticaria?

Author

Avcı A, Avcı D, Ertas R, Atasoy M, Karakukcu C, Yontar E, Ulas Y, and Ozyurt K

Abstract

Introduction: It is known that serum dehydroepiandrosterone sulphate (DHEA-S) levels are low in patients with chronic idiopathic urticaria., Aim: In the study, the effect of the drug on the DHEA-S serum levels and its correlation with the remission and relapse times of the disease was investigated., Material and Methods: Fifty-seven patients with chronic idiopathic urticaria who were referred to our hospital and 20 healthy volunteers were included in the study. A subcutaneous injection of 300 mg omalizumab was administered to the patient group. Drug injections at this dose were completed (6 injections in total, one per month). Relations between serum DHEA-S levels and relapse rates, treatment response and remission duration of the patients and control group were investigated in the groups., Results: Median DHEA-S value before treatment was 116.3 (21.5-448.7) µg/dl; the median DHEA-S value measured after 3 months was 98.4 (10.0-410.0) µg/dl ( p = 0.003). The median DHEA-S value before treatment was 123.1 (21.5-299.6) µg/dl when the initial and 3-month DHEA-S levels of the 34 complete remission patients were compared; after 3 months the value was 100.4 (23.1-301.9) µg/dl ( p = 0.021)., Conclusions: This is the first study to investigate the effect of omalizumab treatment on DHEA-S levels in the treatment of chronic urticaria according to our literature review. The DHEA-S levels were found to be significantly lower after omalizumab therapy but not related to remission and relapse times.

Published
2019
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18. Association between isolated female acne and insulin resistance: a prospective study.

Author

Kartal D, Yildiz H, Ertas R, Borlu M, and Utas S

Subjects
Adult, Blood Glucose metabolism, Case-Control Studies, Female, Glucose Tolerance Test, Humans, Prospective Studies, Severity of Illness Index, Acne Vulgaris pathology, Hyperandrogenism epidemiology, Insulin blood, Insulin Resistance
Abstract

Background: Acne is one of the manifestations of the polycystic ovary syndrome (PCOS). Nowadays hyperinsulinemia and insulin resistance are well-known characteristics of PCOS. The aim of this study was to investigate the relation between isolated female acne and insulin resistance and to determine the effect of hyperandrogenemia in this possible relationship., Methods: Forty five women with acne and 24 healthy women aged 25-40 were included in the study. The global acne grading system (GAGS) was used to evaluate acne severity. Blood samples were drawn for measurements of hormone profile, basal insulin and fasting blood glucose (FBG). The oral glucose tolerance test (OGTT) was performed on another day. homeostasis model assessment (HOMA) score was used to assess insulin resistance (IR). All subjects underwent abdominopelvic sonography., Results: Thirty-six women with acne and 24 healthy women were analyzed after exclusion. Fifteen (42%) patients had moderate acne, 11 (30%) had severe acne and 10 (28%) had very severe acne. Basal insulin, FBG, AUC glucose, AUC insulin and HOMA values were significantly higher in patients with acne when compared with the control group (P<0.05). After excluding patients with hyperandrogenemia, we compared the patients (N.=22) and control group with regard to IR; the serum basal insulin, AUC-insulin and AUC-glucose as well as HOMA score were still significantly higher in patients (P<0.05)., Conclusions: We concluded that there is a relationship between female acne and IR. This association is independent of hyperandrogenemia. Anti-insulin drugs may an adjunctive treatment of female acne.

Published
2016

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