Search

Your search keyword '"Erro, Roberto"' showing total 1,278 results
Start Over Author "Erro, Roberto"
1,278 results on '"Erro, Roberto"'

3. Oromandibular dystonia: from onset to spread a multicenter italian study

Author

Trinchillo, Assunta, Esposito, Marcello, Terranova, Carmen, Rizzo, Vincenzo, Fabbrini, Giovanni, Ferrazzano, Gina, Belvisi, Daniele, Erro, Roberto, Barone, Paolo, Bono, Francesco, Di Biasio, Francesca, Bentivoglio, Anna Rita, Lettieri, Christian, Altavista, Maria Concetta, Scaglione, Cesa Lorella Maria, Albanese, Alberto, Mascia, Marcello Mario, Muroni, Antonella, Pisani, Antonio, Berardelli, Alfredo, and Defazio, Giovanni

Published
2024
Full Text
View/download PDF

5. Does thyroid diseases contribute to the natural history of idiopathic adult-onset dystonia? Data from the Italian Dystonia Registry

Author

Idrissi, Sarah, Velucci, Vittorio, Esposito, Marcello, Trinchillo, Assunta, Habestwallner, Francesco, Belvisi, Daniele, Fabbrini, Giovanni, Ferrazzano, Gina, Rizzo, Vincenzo, Terranova, Carmen, Girlanda, Paolo, Pellicciari, Roberta, Avanzino, Laura, Di Biasio, Francesca, Marchese, Roberta, Bono, Francesco, Idone, Giovanni, Laterza, Vincenzo, Lettieri, Christian, Rinaldo, Sara, Eleopra, Roberto, Castagna, Anna, Altavista, Maria Concetta, Moschella, Vincenzo, Erro, Roberto, Barone, Paolo, Barbero, Pierangelo, Ceravolo, Roberto, Mazzucchi, Sonia, Mascia, Marcello Mario, Ercoli, Tommaso, Muroni, Antonella, Zibetti, Maurizio, Lopiano, Leonardo, Scaglione, Cesa Lorella Maria, Bentivoglio, Anna Rita, Petracca, Martina, Magistrelli, Luca, Cotelli, Maria Sofia, Cossu, Giovanni, Squintani, Giovanna Maddalena, De Santis, Tiziana, Schirinzi, Tommaso, Misceo, Salvatore, Pisani, Antonio, Berardelli, Alfredo, and Defazio, Giovanni

Published
2024
Full Text
View/download PDF

10. Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease

Author

Marano, Massimo, Zizzo, Carmela, Malaguti, Maria Chiara, Bacchin, Ruggero, Cavallieri, Francesco, De Micco, Rosa, Spagnolo, Francesca, Bentivoglio, Anna Rita, Schirinzi, Tommaso, Bovenzi, Roberta, Ramat, Silvia, Erro, Roberto, Sorrentino, Cristiano, Sucapane, Patrizia, Pilotto, Andrea, Lupini, Alessandro, Magliozzi, Alessandro, Di Vico, Ilaria, Carecchio, Miryam, Bonato, Giulia, Cilia, Roberto, Colucci, Fabiana, Tamma, Filippo, Caputo, Elena, Mostile, Giovanni, Arabia, Gennarina, Modugno, Nicola, Zibetti, Maurizio, Ceravolo, Maria Gabriella, Tambasco, Nicola, Cossu, Giovanni, Valzania, Franco, Manganotti, Paolo, Di Lazzaro, Vincenzo, Zappia, Mario, Fabbrini, Giovanni, Tinazzi, Michele, Tessitore, Alessandro, Duro, Giovanni, and Di Fonzo, Alessio

Published
2024
Full Text
View/download PDF

13. Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Author

Zaccone, Claudio, Cerne, Denise, Idone, Giovanni, Ferrazzano, Gina, Rinaldo, Sara, Humaidan, Kais, Devigili, Grazia, Polidori, Luigi, Mazzucchi, Sonia, Ramella, Marina, Ledda, Claudia, Petracca, Martina, Oppo, Valentina, Contaldi, Elena, Turla, Marinella, Gigante, Angelo Fabio, Valentino, Francesca, Cassano, Daniela, Modugno, Nicola, Tambasco, Nicola, Aguggia, Marco, Romano, Marcello, Marinelli, Lucio, Mascia, Marcello Mario, Belvisi, Daniele, Esposito, Marcello, Pellicciari, Roberta, Trinchillo, Assunta, Terranova, Carmen, Bertino, Salvatore, Avanzino, Laura, Di Biasio, Francesca, Bono, Francesco, Laterza, Vincenzo, Lettieri, Christian, Eleopra, Roberto, Fabbrini, Giovanni, Barbero, Pierangelo, Bertolasi, Laura, Altavista, Maria Concetta, Erro, Roberto, Ceravolo, Roberto, Castagna, Anna, Zibetti, Maurizio, Bentivoglio, Anna Rita, Cossu, Giovanni, Magistrelli, Luca, Scaglione, Cesa, Albanese, Alberto, Cotelli, Maria Sofia, Misceo, Salvatore, Pisani, Antonio, Schirinzi, Tommaso, Maderna, Luca, Squintani, Giovanna, Berardelli, Alfredo, and Defazio, Giovanni

Published
2023
Full Text
View/download PDF

15. Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?

Author

Ercoli, Tommaso, Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Spano, Giorgio, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Stocchi, Fabrizio, and Defazio, Giovanni

Published
2022
Full Text
View/download PDF

17. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
Full Text
View/download PDF

31. A window into the mind-brain-body interplay: Development of diagnostic, prognostic biomarkers, and rehabilitation strategies in functional motor disorders.

Author

Gandolfi, Marialuisa, Sandri, Angela, Mariotto, Sara, Tamburin, Stefano, Paolicelli, Anna, Fiorio, Mirta, Pedrotti, Giulia, Barone, Paolo, Pellecchia, Maria Teresa, Erro, Roberto, Cuoco, Sofia, Carotenuto, Immacolata, Vinciguerra, Claudia, Botto, Annibale, Zenere, Lucia, Canu, Elisa, Sibilla, Elisa, Filippi, Massimo, Sarasso, Elisabetta, and Agosta, Federica

Subjects
MOVEMENT disorders, PROGNOSIS, NEUROLOGICAL disorders, DELAYED diagnosis, PSYCHOLOGICAL factors, INTEROCEPTION
Abstract

Background and aims: Functional motor disorders (FMD) present a prevalent, yet misunderstood spectrum of neurological conditions characterized by abnormal movements (i.e., functional limb weakness, tremor, dystonia, gait impairments), leading to substantial disability and diminished quality of life. Despite their high prevalence, FMD often face delayed diagnosis and inadequate treatment, resulting in significant social and economic burdens. The old concept of psychological factors as the primary cause (conversion disorder) has been abandoned due to the need for more evidence about their causal role. According to a predictive coding account, the emerging idea is that symptoms and disability may depend on dysfunctions of a specific neural system integrating interoception, exteroception, and motor control. Consequently, symptoms are construed as perceptions of the body's state. Besides the main pathophysiological features (abnormal attentional focus, beliefs/expectations, and sense of agency), the lived experience of symptoms and their resulting disability may depend on an altered integration at the neural level of interoception, exteroception, and motor control. Methods and materials: Our proposal aims to elucidate the pathophysiological mechanisms of FMD through a three-stage research approach. Initially, a large cohort study will collect behavioral, neurophysiological, and MRI biomarkers from patients with FMD and healthy controls, employing eXplainable Artificial Intelligence (XAI) to develop a diagnostic algorithm. Subsequently, validation will occur using patients with organic motor disorders. Finally, the algorithm's prognostic value will be explored post-rehabilitation in one subgroup of patients with FMD. Results: Data collection for the present study started in May 2023, and by May 2025, data collection will conclude. Discussion: Our approach seeks to enhance early diagnosis and prognostication, improve FMD management, and reduce associated disability and socio-economic costs by identifying disease-specific biomarkers. Trial registration: This trial was registered in clinicaltrials.gov (NCT06328790). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Functional motor phenotypes: to lump or to split?

Author

Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Magro, Giuseppe, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Zanolin, Elisabetta, Albanese, Alberto, Ferrazzano, Gina, De Micco, Rosa, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Ercoli, Tommaso, Morgante, Francesca, and Erro, Roberto

Published
2021
Full Text
View/download PDF

33. Direct Current Stimulation of Prefrontal Cortex Is Not Effective in Progressive Supranuclear Palsy: A Randomized Trial

Author

Cappiello, Arianna, primary, Abate, Filomena, additional, Adamo, Sarah, additional, Tepedino, Maria Francesca, additional, Donisi, Leandro, additional, Ricciardi, Carlo, additional, Avallone, Anna Rosa, additional, Caterino, Miriam, additional, Cuoco, Sofia, additional, Pellecchia, Maria Teresa, additional, Amboni, Marianna, additional, Barone, Paolo, additional, Erro, Roberto, additional, and Picillo, Marina, additional

Published
2024
Full Text
View/download PDF

34. Does sex influence the natural history of idiopathic adult-onset dystonia?

Author

Velucci, Vittorio, primary, Idrissi, Sarah, additional, Pellicciari, Roberta, additional, Esposito, Marcello, additional, Trinchillo, Assunta, additional, Belvisi, Daniele, additional, Fabbrini, Giovanni, additional, Ferrazzano, Gina, additional, Terranova, Carmen, additional, Girlanda, Paolo, additional, Majorana, Giovanni, additional, Rizzo, Vincenzo, additional, Bono, Francesco, additional, Idone, Giovanni, additional, Laterza, Vincenzo, additional, Avanzino, Laura, additional, Di Biasio, Francesca, additional, Marchese, Roberta, additional, Castagna, Anna, additional, Ramella, Marina, additional, Lettieri, Christian, additional, Rinaldo, Sara, additional, Altavista, Maria Concetta, additional, Polidori, Luigi, additional, Bertolasi, Laura, additional, Tozzi, Maria Chiara, additional, Erro, Roberto, additional, Barone, Paolo, additional, Barbero, Pierangelo, additional, Ceravolo, Roberto, additional, Mascia, Marcello Mario, additional, Ercoli, Tommaso, additional, Muroni, Antonella, additional, Artusi, Carlo Alberto, additional, Zibetti, Maurizio, additional, Scaglione, Cesa Lorella Maria, additional, Bentivoglio, Anna Rita, additional, Cotelli, Maria Sofia, additional, Magistrelli, Luca, additional, Cossu, Giovanni, additional, Albanese, Alberto, additional, Squintani, Giovanna Maddalena, additional, Schirinzi, Tommaso, additional, Gigante, Angelo Fabio, additional, Maderna, Luca, additional, Eleopra, Roberto, additional, Pisani, Antonio, additional, Cassano, Daniela, additional, Romano, Marcello, additional, Rizzo, Marina, additional, Berardelli, Alfredo, additional, and Defazio, Giovanni, additional

Published
2024
Full Text
View/download PDF

35. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
Full Text
View/download PDF

37. Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site

Author

Cimino, Paola, Scannapieco, Sara, Ferrazzano, Gina, Brigandì, Amelia, Habetswallner, Francesco, Pascarella, Angelo, Ialongo, Tamara, Ramella, Marina, Mazzucchi, Sonia, Moschella, Vincenzo, Ercoli, Tommaso, Erro, Roberto, Fabbrini, Giovanni, Pellicciari, Roberta, Girlanda, Paolo, Terranova, Carmen, Avanzino, Laura, Di Biasio, Francesca, Barone, Paolo, Esposito, Marcello, De Joanna, Gabriella, Eleopra, Roberto, Bono, Francesco, Manzo, Lucia, Bentivoglio, Anna Rita, Petracca, Martina, Mascia, Marcello Mario, Albanese, Alberto, Castagna, Anna, Ceravolo, Roberto, Altavista, Maria Concetta, Scaglione, Cesa, Magistrelli, Luca, Zibetti, Maurizio, Bertolasi, Laura, Coletti Moja, Mario, Cotelli, Maria Sofia, Cossu, Giovanni, Minafra, Brigida, Pisani, Antonio, Misceo, Salvatore, Modugno, Nicola, Romano, Marcello, Cassano, Daniela, Berardelli, Alfredo, and Defazio, Giovanni

Published
2021
Full Text
View/download PDF

38. Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials

Author

Espay, Alberto J, Schwarzschild, Michael A, Tanner, Caroline M, Fernandez, Hubert H, Simon, David K, Leverenz, James B, Merola, Aristide, Chen‐Plotkin, Alice, Brundin, Patrik, Kauffman, Marcelo A, Erro, Roberto, Kieburtz, Karl, Woo, Daniel, Macklin, Eric A, Standaert, David G, and Lang, Anthony E

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Parkinson's Disease, Neurodegenerative, Prevention, Brain Disorders, Aging, Neurological, Good Health and Well Being, Biomarkers, Clinical Trials as Topic, Humans, Parkinson Disease, Parkinson's disease, biomarkers, neuroprotection, systems biology, Human Movement and Sports Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach to PD: A single-mechanism therapy can affect most of those sharing the classic pathological hallmark. From a systems-biology perspective, PD is a group of disorders that, while related by sharing the feature of nigral dopamine-neuron degeneration, exhibit unique genetic, biological, and molecular abnormalities, which probably respond differentially to a given therapeutic approach, particularly for strategies aimed at neuroprotection. Under this model, only biomarker-defined, homogenous subtypes of PD are likely to respond optimally to therapies proven to affect the biological processes within each subtype. Therefore, we suggest that precision medicine applied to PD requires a reevaluation of the biomarker-discovery effort. This effort is currently centered on correlating biological measures to clinical features of PD and on identifying factors that predict whether various prodromal states will convert into the classical movement disorder. We suggest, instead, that subtyping of PD requires the reverse view, where abnormal biological signals (i.e., biomarkers), rather than clinical definitions, are used to define disease phenotypes. Successful development of disease-modifying strategies will depend on how relevant the specific biological processes addressed by an intervention are to the pathogenetic mechanisms in the subgroup of targeted patients. This precision-medicine approach will likely yield smaller, but well-defined, subsets of PD amenable to successful neuroprotection. © 2017 International Parkinson and Movement Disorder Society.

Published
2017

40. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, Albanese, Alberto (ORCID:0000-0002-5864-0006), Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

BackgroundFunctional motor disorders (FMD) are a frequent neurological condition affecting patients with movement disorders. Commonly described in younger adults, their manifestation can be also associated to an elderly onset.ObjectiveTo assess the prevalence and describe the clinical manifestations of FMD with elderly and younger onset and their relationship with demographical and clinical variables.MethodsWe recruited patients with a "clinically definite" diagnosis of FMD from the Italian Registry of FMD. Patients underwent extensive clinical assessments. For elderly onset, we set a chronological cut-off at 65 years or older according to WHO definition. Multivariate regression models were implemented to estimate adjusted odds ratio of elderly FMD onset related to clinical characteristics.ResultsAmong the 410 patients, 34 (8.2%) experienced elderly-onset FMD, with a mean age at onset of 70.9 years. The most common phenotype was tremor (47.1%), followed by gait disorders, weakness, and dystonia (29.4%, 23.5%, 14.7%, respectively). Eleven elderly patients had a combined phenomenology: 9 exhibited two phenotypes, 2 had three phenotypes. Weakness was isolated in 3/8 patients and combined with another phenotype in 5/8, manifesting as paraplegia (n = 4); upper limb diplegia (n = 2), hemiparesis/hemiplegia (n = 1), and tetraparesis/tetraplegia (n= 1). Non-motor and other functional neurological disorders occurred more frequently in the younger group (89.1%) than the elderly (73.5%). Neurological and non-neurological comorbidities were more prevalent in the elderly group (82.4%) as opposed to the younger (32.7%). In a multivariate regression analysis, elderly-onset FMD was significantly associated with neurological comorbidities, including parkinsonism (OR 6.73) and cerebrovascular diseases (OR 5.48).ConclusionsThese results highlight the importance of achieving an accurate diagnosis of FMD in the elderly, as it is crucial for effectively managing FMD symptoms and addressi

Published
2024

41. Anticipating Tomorrow: Tailoring Parkinson's Symptomatic Therapy Using Predictors of Outcome.

Author

Postuma, Ronald B., Weintraub, Daniel, Simuni, Tanya, Rodríguez‐Violante, Mayela, Leentjens, Albert F.G., Hu, Michele T., Espay, Alberto J., Erro, Roberto, Dujardin, Kathy, Bohnen, Nicolaas I., Berg, Daniela, Mestre, Tiago A., and Marras, Connie

Subjects
PARKINSON'S disease, MOVEMENT disorders, TASK forces, DISEASE progression, COGNITION disorders
Abstract

Background: Although research into Parkinson's disease (PD) subtypes and outcome predictions has continued to advance, recommendations for using outcome prediction to guide current treatment decisions remain sparse. Objectives: To provide expert opinion‐based recommendations for individually tailored PD symptomatic treatment based on knowledge of risk prediction and subtypes. Methods: Using a modified Delphi approach, members of the Movement Disorders Society (MDS) Task Force on PD subtypes generated a series of general recommendations around the question: "Using what you know about genetic/biological/clinical subtypes (or any individual‐level predictors of outcome), what advice would you give for selecting symptomatic treatments for an individual patient now, based on what their subtype or individual characteristics predict about their future disease course?" After four iterations and revisions, those recommendations with over 75% endorsement were adopted. Results: A total of 19 recommendations were endorsed by a group of 13 panelists. The recommendations primarily centered around two themes: (1) incorporating future risk of cognitive impairment into current treatment plans; and (2) identifying future symptom clusters that might be forestalled with a single medication. Conclusions: These recommendations provide clinicians with a framework for integrating future outcomes into patient‐specific treatment choices. They are not prescriptive guidelines, but adaptable suggestions, which should be tailored to each individual. They are to be considered as a first step of a process that will continue to evolve as additional stakeholders provide new insights and as new information becomes available. As individualized risk prediction advances, the path to better tailored treatment regimens will become clearer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

42. Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.

Author

Erro, Roberto, Lazzeri, Giulia, Terranova, Carmen, Paparella, Giulia, Gigante, Angelo Fabio, De Micco, Rosa, Magistrelli, Luca, Di Biasio, Francesca, Valentino, Francesca, Moschella, Vincenzo, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Malaguti, Maria Chiara, Ceravolo, Roberto, Dallocchio, Carlo, Spagnolo, Francesca, Nicoletti, Alessandra, De Rosa, Anna, and Di Giacopo, Raffaella

Subjects
*ESSENTIAL tremor, *TREMOR, *DYSTONIA, *SEX distribution, *REGRESSION analysis, *QUALITY of life
Abstract

Background: Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non‐parkinsonian tremors is relatively high. Objectives: To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD). Methods: We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life. Results: Three‐hundred‐eighty‐three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task‐specificity, and position‐dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor. Conclusions: Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra‐group heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Transitioning from Subtyping to Precision Medicine in Parkinson's Disease: A Purpose‐Driven Approach

Author

Marras, Connie, primary, Fereshtehnejad, Seyed‐Mohammad, additional, Berg, Daniela, additional, Bohnen, Nicolaas I., additional, Dujardin, Kathy, additional, Erro, Roberto, additional, Espay, Alberto J., additional, Halliday, Glenda, additional, Van Hilten, Jacobus J., additional, Hu, Michele T., additional, Jeon, Beomseok, additional, Klein, Christine, additional, Leentjens, Albert F.G., additional, Mollenhauer, Brit, additional, Postuma, Ronald B., additional, Rodríguez‐Violante, Mayela, additional, Simuni, Tanya, additional, Weintraub, Daniel, additional, Lawton, Michael, additional, and Mestre, Tiago A., additional

Published
2024
Full Text
View/download PDF

48. Dominant VPS16 Pathogenic Variants: Not Only Isolated Dystonia

Author

Monfrini, Edoardo, primary, Avanzino, Laura, additional, Palermo, Giovanni, additional, Bonato, Giulia, additional, Brescia, Gloria, additional, Ceravolo, Roberto, additional, Cantarella, Giovanna, additional, Mandich, Paola, additional, Prokisch, Holger, additional, Storm van's Gravesande, Karin, additional, Straccia, Giulia, additional, Elia, Antonio, additional, Reale, Chiara, additional, Panteghini, Celeste, additional, Zorzi, Giovanna, additional, Eleopra, Roberto, additional, Erro, Roberto, additional, Carecchio, Miryam, additional, Garavaglia, Barbara, additional, Zech, Michael, additional, Romito, Luigi, additional, and Di Fonzo, Alessio, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results